Faculty Profiles - ARIMA, Hiroshi

Papers - ARIMA, Hiroshi

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Dapagliflozinは脂質と食塩の過剰摂取によって生じる耐糖能異常を改善する

廣瀬友矩, 高木博史, 久納光皓, 佐々木智之, 孫汝楠, 杉山摩利子, 坂野僚一, 有馬寛

糖尿病 Vol. 66 ( Suppl.1 ) page： S - 232 2023.4

Subcutaneous transplantation of human embryonic stem cells-derived pituitary organoids

Sasaki, H; Suga, H; Takeuchi, K; Nagata, Y; Harada, H; Kondo, T; Ito, E; Maeda, S; Sakakibara, M; Soen, M; Miwata, T; Asano, T; Ozaki, H; Taga, S; Kuwahara, A; Nakano, T; Arima, H; Saito, R

FRONTIERS IN ENDOCRINOLOGY Vol. 14 page： 1130465 2023.3

Resting energy expenditure depends on energy intake during weight loss in people with obesity: a retrospective cohort study. Reviewed International journal

Tomoko Handa, Takeshi Onoue, Tomoko Kobayashi, Eri Wada, Ayaka Hayase, Tamaki Kinoshita, Ayana Yamagami, Yoshinori Yasuda, Shintaro Iwama, Yohei Kawaguchi, Takashi Miyata, Mariko Sugiyama, Hiroshi Takagi, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Motomitsu Goto, Hiroshi Arima

Archives of endocrinology and metabolism Vol. 67 ( 2 ) page： 233 - 241 2023.3

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Resting energy expenditure (REE) decreases if there is reduced energy intake and body weight (BW). The decrease in REE could make it difficult for patients with obesity to maintain decreased BW. This study aimed to investigate the correlation among changes in REE, energy intake, and BW during the weight loss process in patients with obesity. MATERIALS AND METHODS: We conducted a retrospective cohort study of patients hospitalized for the treatment of obesity in Japan. Patients received fully controlled diet during hospitalization and performed exercises if able. REE was measured once a week using a hand-held indirect calorimetry. Energy intake was determined by actual dietary intake. RESULTS: Of 44 inpatients with obesity, 17 were included in the analysis. Their BW decreased significantly after 1 week (-4.7 ± 2.0 kg, P < 0.001) and 2 weeks (-5.7 ± 2.2 kg, P < 0.001). The change in REE after 1 and 2 weeks was positively correlated with the energy intake/energy expenditure ratio (r = 0.66, P = 0.004 at 1 week, r = 0.71, P = 0.002 at 2 weeks). Using a regression equation (y = 0.5257x - 43.579), if the energy intake/energy expenditure ratio within the second week was 82.9%, the REE after 2 weeks was similar to the baseline level. There was no significant correlation between the change in REE and BW. CONCLUSION: Our data suggest that changes in REE depend on energy intake/energy expenditure ratio and that the decrease in REE can be minimized by matching energy intake to energy expenditure, even during the weight loss process.

DOI： 10.20945/2359-3997000000532

Web of Science

PubMed

抗PD-L1抗体による甲状腺障害の発症リスク因子の検討

小林朋子, 岩間信太郎, 山上綾菜, 周きん, 伊藤雅晃, 安田康紀, 有馬寛

日本内分泌学会雑誌 Vol. 98 ( 5 ) page： 1294 - 1294 2023.3

放射線治療とパシレオチドの併用が奏功したクッシング病の1例

村瀬萌絵, 安田康紀, 杉山摩利子, 永田雄一, 竹内和人, 井下尚子, 有馬寛

日本内分泌学会雑誌 Vol. 98 ( 5 ) page： 1401 - 1401 2023.3

Pyogenic spondylitis due to <i>Streptococcus agalactiae</i> with paraspinal abscess and vertebral destruction in a diabetic patient: time course of imagings Reviewed

Kobayashi, T; Iwata, T; Handa, K; Arima, H

ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS Vol. 2023 ( 1 ) 2023.1

Knockdown of endoplasmic reticulum chaperone BiP leads to the death of parvocellular AVP/CRH neurons in mice. Reviewed International journal

Yohei Kawaguchi, Daisuke Hagiwara, Tetsuro Tsumura, Takashi Miyata, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Yoshinori Yasuda, Shintaro Iwama, Hidetaka Suga, Ryoichi Banno, Valery Grinevich, Hiroshi Arima

Journal of neuroendocrinology Vol. 35 ( 1 ) page： e13223 2023.1

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Arginine vasopressin (AVP) is expressed in both magnocellular (magnAVP) and parvocellular AVP (parvAVP) neurons of the paraventricular nucleus, and AVP colocalizes with corticotropin-releasing hormone (CRH) only in the parvocellular neurons. The immunoglobulin heavy chain binding protein (BiP) is a major endoplasmic reticulum (ER) chaperone which regulates the unfolded protein response under ER stress. We previously demonstrated that knockdown of BiP in magnAVP neurons exacerbated ER stress, which resulted in the autophagy-associated cell death of magnAVP neurons. Using the same approach, in the present study we examined the role of BiP in mouse parvAVP/CRH neurons. Our data demonstrate that BiP is expressed in mouse parvAVP/CRH neurons under nonstress conditions and is upregulated in proportion to the increase in CRH expression after adrenalectomy. For BiP knockdown in parvAVP/CRH neurons, we utilized a viral approach in combination with shRNA interference. Knockdown of BiP expression induced ER stress in parvAVP/CRH neurons, as reflected by the expression of C/EBP homologous protein. Furthermore, BiP knockdown led to the loss of parvAVP/CRH neurons after 4 weeks. In summary, our results demonstrate that BiP plays a pivotal role in parvAVP/CRH neurons, which function as neuroendocrine cells producing a large number of secretory proteins.

DOI： 10.1111/jne.13223

Web of Science

PubMed

Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency. Open Access

Junki Kurimoto, Hiroshi Takagi, Takashi Miyata, Yohei Kawaguchi, Yuichi Hodai, Tetsuro Tsumura, Daisuke Hagiwara, Tomoko Kobayashi, Yoshinori Yasuda, Mariko Sugiyama, Takeshi Onoue, Shintaro Iwama, Hidetaka Suga, Ryoichi Banno, Takeshi Katsuki, Fumiaki Ando, Shinichi Uchida, Hiroshi Arima

Endocrine journal Vol. 70 ( 3 ) page： 295 - 304 2023

Language：English Publishing type：Research paper (scientific journal)

The symptoms of diabetes insipidus may be masked by the concurrence of adrenal insufficiency and emerge after the administration of hydrocortisone, occasionally at high doses. To elucidate the mechanism underlying polyuria induced by the administration of high-dose corticosteroids in the deficiency of arginine vasopressin (AVP), we first examined the secretion of AVP in three patients in whom polyuria was observed only after the administration of high-dose corticosteroids. Next, we examined the effects of dexamethasone or aldosterone on water balance in wild-type and familial neurohypophysial diabetes insipidus (FNDI) model mice. A hypertonic saline test showed that AVP secretion was partially impaired in all patients. In one patient, there were no apparent changes in AVP secretion before and after the administration of high-dose corticosteroids. In FNDI mice, unlike dexamethasone, the administration of aldosterone increased urine volumes and decreased urine osmolality. Immunohistochemical analyses showed that, after the administration of aldosterone in FNDI mice, aquaporin-2 expression was decreased in the apical membrane and increased in the basolateral membrane in the collecting duct. These changes were not observed in wild-type mice. The present data suggest that treatment with mineralocorticoids induces polyuria by reducing aquaporin-2 expression in the apical membrane of the kidney in partial AVP deficiency.

DOI： 10.1507/endocrj.EJ22-0339

Open Access

Web of Science

PubMed

Response to endoplasmic reticulum stress in arginine vasopressin neurons. Invited

Daisuke Hagiwara, Yoshinori Azuma, Yohei Kawaguchi, Takashi Miyata, Hiroshi Arima

Endocrine journal Vol. 70 ( 6 ) page： 567 - 572 2023

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

Arginine vasopressin (AVP) is an antidiuretic hormone synthesized principally in the hypothalamic supraoptic and paraventricular nuclei. The immunoglobulin heavy chain binding protein (BiP), one of the most abundant endoplasmic reticulum (ER) chaperones, is highly expressed in AVP neurons, even under basal conditions. Moreover, its expression is upregulated in proportion to the increase in AVP expression under dehydration. These data suggest that AVP neurons are constantly exposed to ER stress. BiP knockdown in AVP neurons induces ER stress and autophagy, resulting in AVP neuronal loss, indicating that BiP is pivotal in maintaining the AVP neuron system. Furthermore, inhibition of autophagy after BiP knockdown exacerbates AVP neuronal loss, suggesting that autophagy induced under ER stress is a protective cellular mechanism by which AVP neurons cope with ER stress. Familial neurohypophysial diabetes insipidus (FNDI) is an autosomal dominant disorder caused by mutations in the AVP gene. It is characterized by delayed-onset progressive polyuria and eventual AVP neuronal loss. In AVP neurons of FNDI model mice, mutant protein aggregates are confined to a specific compartment of the ER, called the ER-associated compartment (ERAC). The formation of ERACs contributes to maintaining the function of the remaining intact ER, and mutant protein aggregates in ERACs undergo autophagic-lysosomal degradation without isolation or translocation from the ER, representing a novel protein degradation system in the ER.

DOI： 10.1507/endocrj.EJ23-0193

Web of Science

PubMed

A retrospective study on tolvaptan prescription in clinical practice in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) using the Japanese claims database Reviewed

Hagiwara, D; Matsukawa, M; Tasaki, J; Nakamura, Y; Arima, H

ENDOCRINE JOURNAL Vol. 70 ( 12 ) page： 1195 - 1205 2023

Changing the Name of Diabetes Insipidus: A Position Statement of the Working Group for Renaming Diabetes Insipidus. Reviewed

Arima H, Cheetham T, Christ-Crain M, Cooper D, Drummond J, Gurnell M, Levy M, McCormack A, Newell-Price J, Verbalis JG, Wass J, Working Group for Renaming Diabetes Insipidus

The Journal of clinical endocrinology and metabolism Vol. 108 ( 1 ) page： 1 - 3 2022.12

Changing the name of diabetes insipidus

Arima, H; Bichet, DG; Cheetham, T; Christ-Crain, M; Drummond, J; Gurnell, M; Levy, M; McCormack, A; Newell-Price, J; Verbalis, JG; Wass, J; Cooper, D

PITUITARY Vol. 25 ( 6 ) page： 777 - 779 2022.12

Changing the name of diabetes insipidus: a position statement of The Working Group for Renaming Diabetes Insipidus.

Working Group for Renaming Diabetes Insipidus, Arima H, Cheetham T, Christ-Crain M, Cooper D, Gurnell M, Drummond JB, Levy M, McCormack AI, Verbalis J, Newell-Price J, Wass JAH

Endocrine journal Vol. 69 ( 11 ) page： 1281 - 1284 2022.11

Changing the name of diabetes insipidus: a position statement of The Working Group for Renaming Diabetes Insipidus

Arima, H; Cheetham, T; Christ-Crain, M; Cooper, D; Gurnell, M; Drummond, JB; Levy, M; McCormack, AI; Verbalis, J; Newell-Price, J; Wass, JAH

ENDOCRINE CONNECTIONS Vol. 11 ( 11 ) 2022.11

Changing the name of diabetes insipidus: a position statement of The Working Group for Renaming Diabetes Insipidus

Arima, H; Cheetham, T; Christ-Crain, M; Cooper, D; Gurnell, M; Drummond, JB; Levy, M; McCormack, A; Verbalis, J; Newell-Price, J; Wass, JAH

EUROPEAN JOURNAL OF ENDOCRINOLOGY Vol. 187 ( 5 ) page： P1 - P3 2022.11

Changing the name of diabetes insipidus: a position statement of the working group to consider renaming diabetes insipidus Open Access

Arima, H; Cheetham, T; Christ-Crain, M; Cooper, DL; Drummond, JB; Gurnell, M; Levy, M; McCormack, A; Newell-Price, JD; Verbalis, JG; Wass, J

ARCHIVES OF ENDOCRINOLOGY METABOLISM Vol. 66 ( 6 ) page： 868 - 870 2022.11

実臨床データに基づいた機械学習による低ナトリウム血症治療における血清ナトリウム濃度予測

木下珠希, 大山慎太郎, 萩原大輔, 有馬寛

医療情報学連合大会論文集 Vol. 42回 page： 1195 - 1200 2022.11

Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state. Reviewed International journal

Hajime Ozaki, Hidetaka Suga, Mayu Sakakibara, Mika Soen, Natsuki Miyake, Tsutomu Miwata, Shiori Taga, Takashi Nagai, Mayuko Kano, Kazuki Mitsumoto, Takashi Miyata, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Shintaro Iwama, Ryoichi Banno, Genzo Iguchi, Yutaka Takahashi, Keiko Muguruma, Haruhisa Inoue, Hiroshi Arima

Scientific reports Vol. 12 ( 1 ) page： 17381 - 17381 2022.10

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

Familial neurohypophyseal diabetes insipidus (FNDI) is a degenerative disease of vasopressin (AVP) neurons. Studies in mouse in vivo models indicate that accumulation of mutant AVP prehormone is associated with FNDI pathology. However, studying human FNDI pathology in vivo is technically challenging. Therefore, an in vitro human model needs to be developed. When exogenous signals are minimized in the early phase of differentiation in vitro, mouse embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs) differentiate into AVP neurons, whereas human ESCs/iPSCs die. Human ESCs/iPSCs are generally more similar to mouse epiblast stem cells (mEpiSCs) compared to mouse ESCs. In this study, we converted human FNDI-specific iPSCs by the naive conversion kit. Although the conversion was partial, we found improved cell survival under minimal exogenous signals and differentiation into rostral hypothalamic organoids. Overall, this method provides a simple and straightforward differentiation direction, which may improve the efficiency of hypothalamic differentiation.

DOI： 10.1038/s41598-022-22405-8

Web of Science

PubMed

機械学習を用いた重症低ナトリウム血症の治療予測システムの構築

木下珠希, 萩原大輔, 大山慎太郎, 有馬寛

日本内分泌学会雑誌 Vol. 98 ( 2 ) page： 554 - 554 2022.10

Changing the Name of Diabetes Insipidus: A Position Statement of the Working Group to Consider Renaming Diabetes Insipidus

Arima, H; Cheetham, T; Christ-Crain, M; Cooper, DL; Drummond, JB; Gurnell, M; Levy, M; McCormack, A; Newell-Price, JD; Verbalis, JG; Wass, J

HORMONE RESEARCH IN PAEDIATRICS Vol. 96 ( 4 ) page： 423 - 425 2022.9

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Papers - ARIMA, Hiroshi