Faculty Profiles - ARIMA, Hiroshi

Papers - ARIMA, Hiroshi

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NMDA receptor antagonist prevents cell death in the hippocampal dentate gyrus induced by hyponatremia accompanying adrenal insufficiency in rats

Hisakazu Izumida, Hiroshi Takagi, Haruki Fujisawa, Naoko Iwata, Kohtaro Nakashima, Seiji Takeuchi, Shintaro Iwama, Takashi Namba, Yukio Komatu, Kozo Kaibuchi, Yutaka Oiso, Hiroshi Arima, Yoshihisa Sugimura

EXPERIMENTAL NEUROLOGY Vol. 287 ( Pt 1 ) page： 65 - 74 2017.1

Language：English Publishing type：Research paper (scientific journal) Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE

Selective apoptosis of granule cells in the hippocampal dentate gyrus (DG) of rats with bilateral adrenalectomy (ADX) and in patients who died of adrenal insufficiency has been reported. Although adrenal insufficiency is a common disease and is usually associated with hyponatremia, its effect on the central nervous system and in apoptosis in the hippocampus remain to be elucidated. Using rat models to represent clinical hyponatremia accompanying adrenal insufficiency, we show that reduced serum [Na+] was associated with selective apoptosis in the DG. Nine days after ADX, apoptotic cells were observed in the DG of rats whose serum [Na+] was <125 mEq/L (moderate hyponatremia), but rarely in those whose serum [Na+] was 125 mEq/L or in normonatremic rats. Although all hyponatremic ADX rats survived following treatment with corticosterone and saline started 7 days after ADX when apoptosis had not yet occurred, selective apoptosis on day 9 was not prevented in moderately hyponatremic rats. Interestingly, treatment with memantine, a noncompetitive NMDAR antagonist, prevented the selective apoptosis in the DG in moderately hyponatremic, ADX rats, and improved electrophysiological dysfunction, including impaired basal synaptic transmission and long-term potentiation at the entorhinal cortex-DG synapses. These results demonstrated that in adrenal insufficient rats, hyponatremia was associated with apoptosis in the DG, and that memantine prevented the apoptosis and improved cell function. Our data imply the importance of assessing the possibility of neurological impairments after treatment with CORT in patients with moderate or severe hyponatremia accompanying adrenal insufficiency and that memantine may represent a beneficial therapeutic strategy to prevent neurological impairments in such patients. (C) 2016 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.expneurol.2016.08.007

Web of Science

PubMed

IgG4関連下垂体炎における抗下垂体抗体の解析

岩田尚子, 岩間信太郎, 安田康紀, 椙村益久, 有馬寛

日本内分泌学会雑誌 Vol. 92 ( 3 ) page： 731 - 731 2017.1

水バランスの調節バソプレシンニューロンと小胞体ストレス

萩原大輔, 宮田崇, 橡谷昌佳, 東慶成, 森下啓明, 有馬寛

日本内分泌学会雑誌 Vol. 92 ( 3 ) page： 717 - 717 2017.1

家族性中枢性尿崩症モデルマウスに対するケミカルシャペロン4-Phenylbutyric acidの治療効果の検討

橡谷昌佳, 萩原大輔, 宮田崇, 東慶成, 森下啓明, 有馬寛

日本内分泌学会雑誌 Vol. 92 ( 3 ) page： 734 - 734 2017.1

ニボルマブに伴う甲状腺障害に関する前向き臨床研究(中間報告)

岩間信太郎, 小林朋子, 安田康紀, 岩田尚子, 椙村益久, 安藤雄一, 秋山真志, 長谷川好規, 有馬寛

日本内分泌学会雑誌 Vol. 92 ( 3 ) page： 612 - 612 2017.1

イピリムマブ誘発下垂体炎2例の下垂体機能検査およびMRI画像変化に関する検討

岩間信太郎, 小林朋子, 安田康紀, 岩田尚子, 横田憲二, 椙村益久, 安藤雄一, 秋山真志, 有馬寛

日本内分泌学会雑誌 Vol. 92 ( 3 ) page： 731 - 731 2017.1

RPH3A蛋白による下垂体後葉炎モデルマウスの開発

安田康紀, 岩間信太郎, 岩田尚子, 椙村益久, 有馬寛

日本内分泌学会雑誌 Vol. 92 ( 3 ) page： 729 - 729 2017.1

マウスES細胞から視床下部神経への誘導法ではグリア細胞も出現する

須賀英隆, 光本一樹, 山田登美子, 加納麻弓子, 水野正明, 有馬寛

日本内分泌学会雑誌 Vol. 92 ( 3 ) page： 732 - 732 2017.1

Clinical practice and mechanism of endocrinological adverse events associated with immune checkpoint inhibitors Open Access

Shintaro Iwama, Hiroshi Arima

Japanese Journal of Clinical Immunology Vol. 40 ( 2 ) page： 90 - 94 2017

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society for Clinical Immunology

Immune checkpoint inhibitors, used for cancer immunotherapy, show anti-tumor effects through T cell activations. Monoclonal antibodies against cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed cell death (PD)-1, or PD-ligand 1 which is a ligand of PD-1 have been shown to be effective in the treatments of advanced cancers including malignant melanoma, non-small cell lung cancer, and renal cell carcinoma. However, these drugs also have immune-related adverse events (irAEs). The irAEs, which have unique characteristics different from those seen in conventional cytotoxic anti-tumor medicines, are observed in the several tissues such as skin, gastrointestinal tract, liver, lung, muscle, nerve and endocrine systems. To safely use immune checkpoint inhibitors, it is quite important to understand the characteristics of irAEs and to manage them in clinical practice. In this review, we focus on clinical characteristics and pathogenesis of adverse events in the pituitary gland.

DOI： 10.2177/jsci.40.90

Open Access

Scopus

PubMed

Normalization of Bilateral Adrenal Gland Enlargement after Treatment for Cryptococcosis Open Access

Muraoka Yuka, Iwama Shintaro, Arima Hiroshi

CASE REPORTS IN ENDOCRINOLOGY Vol. 2017 page： 1543149 2017

Identification of the novel autoantigen candidate Rab GDP dissociation inhibitor alpha in isolated adenocorticotropin deficiency Reviewed

Kiyota A, Iwama S, Sugimura Y, Takeuchi S, Takagi H, Iwata N, Nakashima K, Suzuki H, Nishioka T, Kato T, Enomoto A, Arima H, Kaibuchi K, Oiso Y

Endocr J Vol. 62 ( 2 ) page： 153-160 2015

Comparison of incidence of hyponatremia between intranasal and oral desmopressin in patients with central diabetes insipidus Reviewed Open Access

Kataoka Y, Nishida S, Hirakawa A, Oiso Y, Arima H

Endocr J Vol. 62 ( 2 ) page： 195-200 2015

Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice Reviewed Open Access

Takahashi A, Lee R, Iwasato T, Itohara S, Arima H, Bettler B, Miczek K, Koide T

J Neurosci Vol. 35 ( 16 ) page： 6452-6463 2015

Rabphilin-3A as a targeted autoantigen in lymphocytic infundibulo-neurohypophysitis Reviewed Open Access

Iwama S, Sugimura Y, Kiyota A, Kato T, Enomoto A, Suzuki H, Iwata N, Takeuchi S, Nakashima K, Takagi H, Izumida H, Ochiai H, Fujisawa H, Suga H, Arima H, Shimoyama Y, Takahashi M, Nishioka H, Ishikawa SE, Shimatsu A, Caturegli P, Oiso Y

J Clin Endocrinol Metab Vol. 100 ( 7 ) page： E946-54 2015

Effect of hyperglycemia on hepatocellular carcinoma development in diabetes Open Access

Niwa Y, Ishikawa K, Ishigami M, Honda T, Achiwa K, Izumoto T, Maekawa R, Hosokawa K, Iida A, Seino Y, Hamada Y, Goto H, Oiso Y, Arima H, Tsunekawa S

Biochem Biophys Res Commun Vol. 463 ( 3 ) page： 344-350 2015

BMP4 and FGF strongly induce differentiation of mouse ES cells into oral ectoderm. Reviewed Open Access

Vol. 15 ( 2 ) page： 290-298 2015

Adipsia increases risk of death in patients with central diabetes insipidus Reviewed Open Access

Arima H, Wakabayashi T, Nagatani T, Fujii M, Hirakawa A, Murase T, Yambe Y, Yamada T, Yamakawa F, Yamamori I, Yamauchi M, Oiso Y

Endocr J Vol. 61 ( 2 ) page： 143-148 2014

Activating transcription factor 6a is required for the vasopressin neuron system to maintain water balance under dehydration in male mice

Azuma Y, Hagimoto D, Lu W, Morishita Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Shiota A, Asai N, Takahashi M, OisoY, Arima H

Endocrinology Vol. 155 page： 4905-4914 2014

Minocycline prevents osmotic demyelination associated with aquaresis Open Access

Takagi H, Sugimura Y, Suzuki H, Iwama S, Izumida H, Fujisawa H, Ogawa K, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Suga H, Goto M, Banno R, Arima H, Oiso Y

Kidney Int Vol. 86 ( 5 ) page： 964-964 2014

Mitogen-activated protein kinase phosphatase 1 negatively regulates MAPK signaling in mouse hypothalamus

Adachi K, Goto M, Onoue T, Tsunekawa T, Shibata M, Hagimoto S, Ito Y, Banno R, Suga H, Sugimura Y, Oiso Y, Arima H

Neurosci Lett Vol. 569 page： 49-54 2014

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Papers - ARIMA, Hiroshi