Faculty Profiles - ARIMA, Hiroshi

Papers - ARIMA, Hiroshi

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マウスES細胞視床下部分化誘導系後期に残存するRax+細胞はTanycytesと類似する

加納麻弓子, 須賀英隆, 有馬寛

日本内分泌学会雑誌 Vol. 94 ( 4 ) page： 1319 - 1319 2018.12

Association of antithyroglobulin antibodies with the development of thyroid dysfunction induced by nivolumab. Reviewed Open Access

Kimbara S, Fujiwara Y, Iwama S, Ohashi K, Kuchiba A, Arima H, Yamazaki N, Kitano S, Yamamoto N, Ohe Y

Cancer science 2018.9

高脂肪食の継続投与はグリア細胞の極性変化を伴い視床下部炎症が増悪する

杉山摩利子, 坂野僚一, 柳沼裕史, 滝啓吾, 溝口暁, 恒川卓, 高木博史, 伊藤禎浩, 小峯起, 山中宏二, 有馬寛

肥満研究 Vol. 24 ( Suppl. ) page： 185 - 185 2018.9

傍鞍部腫瘍術後遅発性低Na血症の発症と予防法の検討

竹内和人, 川端哲平, 永田雄一, 秋禎樹, 石川隆之, 高木博史, 有馬寛, 若林俊彦

日本内分泌学会雑誌 Vol. 94 ( Suppl.HPT ) page： 37 - 40 2018.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(一社)日本内分泌学会

当院で傍鞍部腫瘍に対しeTSS(内視鏡下経鼻経蝶形骨手術)を施行した98例(男性50例、女性48例、平均年齢55.9歳)を対象に、術後の遅発性低Na血症(DHN)発症について検討した。その結果、DHNは37例(37.8%)に認められた。DHN発症患者ではDHN発症時のAVP分泌が抑制されていないことが確認された。また、術後7日目においてDHN非発症患者では約3%程度の体重低下を認めるのに対し、DHN発症例では体重減少は1%程度と軽微であり、体内への水分貯留が示唆された。術前より尿崩症が認められた患者群ではDHN発症が少なかったものの、DHN発症例では渇感中枢障害を伴っていた。これは術後の脱水を危惧したADH補充による医原性のものと考えられた。以上、傍鞍部腫瘍の術後DHNの発症にはSIADHが強く関与していることが考えられた。尚、術後早期からの水分制限はDHN発症予防に有効と考えられたが、より適切なプロトコールならびに予測法の確立が必要である。

Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus International journal Open Access

Masayoshi Tochiya, Daisuke Hagiwara, Yoshinori Azuma, Takashi Miyata, Yoshiaki Morishita, Hidetaka Suga, Takeshi Onoue, Taku Tsunekawa, Hiroshi Takagi, Yoshihiro Ito, Shintaro Iwama, Motomitsu Goto, Ryoichi Banno, Hiroshi Arima

Neuroscience Letters Vol. 682 page： 50 - 55 2018.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Ireland Ltd

Familial neurohypophysial diabetes insipidus (FNDI), characterized by progressive polyuria and loss of arginine vasopressin (AVP) neurons, is an autosomal dominant disorder caused by AVP gene mutations. Our previous studies with FNDI model mice demonstrated that mutant proteins accumulated in the endoplasmic reticulum (ER) of AVP neurons. Here, we examined therapeutic effects of the chemical chaperone 4-phenylbutylate (4-PBA) in FNDI mice. Treatment with 4-PBA reduced mutant protein accumulation in the ER of FNDI mice and increased AVP release, leading to reduced urine volumes. Furthermore, AVP neuron loss under salt loading was attenuated by 4-PBA treatment. These data suggest that 4-PBA ameliorated mutant protein accumulation in the ER of AVP neurons and thereby prevented FNDI phenotype progression.

DOI： 10.1016/j.neulet.2018.06.013

Web of Science

Scopus

PubMed

Functional adenosine triphosphate-sensitive potassium channel is required in high-carbohydrate diet-induced increase in β-cell mass. Reviewed Open Access

2018.8

A novel mechanism of autophagy-associated cell death of vasopressin neurons in familial neurohypophysial diabetes insipidus. Invited Reviewed

Hagiwara D, Grinevich V, Arima H

Cell and tissue research 2018.6

Dipeptidyl peptidase-4 inhibitors-associated bullous pemphigoid: A retrospective study of 168 pemphigoid and 9,304 diabetes mellitus patients. Reviewed Open Access

Kawaguchi Y, Shimauchi R, Nishibori N, Kawashima K, Oshitani S, Fujiya A, Shibata T, Ohashi N, Izumi K, Nishie W, Shimizu H, Arima H, Sobajima H

Journal of diabetes investigation 2018.6

Association of pre-existing thyroid autoimmunity with the development of thyroid dysfunction induced by nivolumab. Reviewed

Kimbara, S; Fujiwara, Y; Iwama, S; Ohashi, K; Kuchiba, A; Arima, H; Yamazaki, N; Kitano, S; Yamamoto, N; Ohe, Y

JOURNAL OF CLINICAL ONCOLOGY Vol. 36 ( 15 ) 2018.5

Functional Pituitary Tissue Generation from Human Embryonic Stem Cells. Reviewed International journal

Kano M, Suga H, Kasai T, Ozone C, Arima H

Current protocols in neuroscience Vol. 83 ( 1 ) page： e48 2018.4

Language：English Publishing type：Research paper (scientific journal)

The anterior pituitary gland produces several hormones essential for regulation of the somatic endocrine system. Deficiency of these hormones can cause life-threatening diseases, including adrenal crisis. Pituitary tissue generated from human pluripotent stem cells is expected to provide better treatment than current hormone replacement therapy. During early mammalian development, the pituitary anlage (Rathke's pouch) develops from non-neural ectoderm adjacent to the developing ventral hypothalamus. The close interaction between these two tissues is crucial for Rathke's pouch development and involves several signaling molecules. Early exposure of human embryonic stem cells in 3D floating culture to sonic hedgehog and bone morphogenetic protein 4 promoted the cells' differentiation into oral ectoderm and, subsequently, hormone-producing cells such as corticotrophs (adrenocorticotropic hormone-producing cells). The differentiation approach described herein, which induces the formation of pituitary tissue in contact with hypothalamic neural tissue, mimics mammalian pituitary development. The differentiated corticotrophs are functional, responding normally to both release and feedback signals. © 2018 by John Wiley & Sons, Inc.

DOI： 10.1002/cpns.48

PubMed

ニボルマブ誘発破壊性甲状腺炎の発症率は甲状腺自己抗体陽性者で有意に高い

小林朋子, 岩間信太郎, 岡田則男, 安田康紀, 有馬寛

日本内分泌学会雑誌 Vol. 94 ( 1 ) page： 420 - 420 2018.4

小胞体内凝集体形成機序の解明家族性中枢性尿崩症モデルマウスを用いた検討

宮田崇, 萩原大輔, 橡谷昌佳, 森下啓明, 坂本浩隆, 有馬寛

日本内分泌学会雑誌 Vol. 94 ( 1 ) page： 385 - 385 2018.4

ペムブロリズマブによる内分泌障害の臨床的特徴(中間報告)

岡田則男, 岩間信太郎, 小林朋子, 安田康紀, 有馬寛

日本内分泌学会雑誌 Vol. 94 ( 1 ) page： 345 - 345 2018.4

マウスES細胞視床下部誘導系におけるTanycytes様細胞の検討

加納麻弓子, 須賀英隆, 山田登美子, 有馬寛

日本内分泌学会雑誌 Vol. 94 ( 1 ) page： 313 - 313 2018.4

小胞体ストレスのin vitro実験系の確立家族性中枢性尿崩症の疾患特異的iPS細胞を用いた検討

光本一樹, 須賀英隆, 加納麻弓子, 大曽根親文, 宮田崇, 橡谷昌佳, 萩原大輔, 佐藤慧太, 坂本浩隆, 有馬寛

日本内分泌学会雑誌 Vol. 94 ( 1 ) page： 290 - 290 2018.4

Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study International journal Open Access

Kobayashi Tomoko, Iwama Shintaro, Yasuda Yoshinori, Okada Norio, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Morishita Yoshiaki, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Yokota Kenji, Hase Tetsunari, Morise Masahiro, Hashimoto Naozumi, Ando Masahiko, Kiyoi Hitoshi, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

JOURNAL OF THE ENDOCRINE SOCIETY Vol. 2 ( 3 ) page： 241 - 251 2018.3

Language：English Publishing type：Research paper (scientific journal)

Context: Immune checkpoint inhibitors, including anti-programmed cell death-1 (PD-1) antibodies, have become promising treatments for a variety of advanced malignancies. However, these medicines can cause immune-related adverse events (irAEs), including endocrinopathies. Objective: This study examined the incidence of endocrine irAEs induced by nivolumab. Patients and Main Outcome Measured: Sixty-six patients treated with nivolumab at Nagoya University Hospital were prospectively evaluated for pituitary hormones, thyroid function, antithyroid antibodies (Abs), and glucose levels every 6 weeks after the initiation of nivolumab for 24 weeks. Results: Four out of 66 patients developed destructive thyroiditis, and three patients developed hypothyroidism requiring levothyroxine replacement. The prevalence of positive anti-thyroglobulin Abs (TgAbs) and/or anti-thyroid peroxidase Abs (TPOAbs) at baseline was significantly higher in the group that developed destructive thyroiditis (3/4) compared with the group that did not develop thyroiditis (3/62; P = 0.002). There were no significant differences in other clinical variables between the groups. There were no endocrine irAEs other than destructive thyroiditis during the 24 weeks. The prevalence of TgAbs and/or TPOAbs at baseline was not associated with the development of other irAEs, including pneumonitis, colitis, or skin reactions. Conclusions: Our real-world data showed that destructive thyroiditis was an endocrine irAE that was frequently induced by nivolumab and was significantly associated with positive TgAbs and/or TPOAbs before treatment. Our findings indicate that evaluating these Abs before treatment may help identify patients with a high risk of thyroidal irAEs and may have important clinical benefit.

DOI： 10.1210/js.2017-00432

Open Access

Web of Science

PubMed

Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors. Reviewed Open Access

Ogawa K, Suga H, Ozone C, Sakakibara M, Yamada T, Kano M, Mitsumoto K, Kasai T, Kodani Y, Nagasaki H, Yamamoto N, Hagiwara D, Goto M, Banno R, Sugimura Y, Arima H

Scientific reports Vol. 8 ( 1 ) page： 3615 2018.2

Glucose-dependent insulinotropic polypeptide is required for moderate high fat diet, but not high carbohydrate diet-induced weight gain. Reviewed Open Access

Maekawa R, Ogata H, Murase M, Harada N, Suzuki K, Joo E, Sankoda A, Iida A, Izumoto T, Tsunekawa S, Hamada Y, Oiso Y, Inagaki N, Arima H, Hayashi Y, Seino Y

American journal of physiology. Endocrinology and metabolism 2018.2

Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis. Reviewed

Yasuda Y, Iwama S, Kiyota A, Izumida H, Nakashima K, Iwata N, Ito Y, Morishita Y, Goto M, Suga H, Banno R, Enomoto A, Takahashi M, Arima H, Sugimura Y

The Journal of pathology 2018.1

Cullin-associated NEDD8-dissociated protein 1, a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cells. Open Access

Nakashima K, Takeuchi S, Iwama S, Kiyota A, Yasuda Y, Iwata N, Enomoto A, Arima H, Sugimura Y

Endocrine journal 2018.1

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Papers - ARIMA, Hiroshi