Papers - KIYOI, Hitoshi
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A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with FLT3 mutations. Reviewed
Yamaura T, Nakatani T, Uda K, Ogura H, Shin W, Kurokawa N, Saito K, Fujikawa N, Date T, Takasaki M, Terada D, Hirai A, Akashi A, Chen F, Adachi Y, Ishikawa Y, Hayakawa F, Hagiwara S, Naoe T, Kiyoi H.
Blood 2017.11
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Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma. Reviewed
Shimada K, Shimada S, Sugimoto K, Nakatochi M, Suguro M, Hirakawa A, Hocking TD, Takeuchi I, Tokunaga T, Takagi Y, Sakamoto A, Aoki T, Naoe T, Nakamura S, Hayakawa F, Seto M, Tomita A, Kiyoi H.
Leukemia. Vol. 30 ( 7 ) page： 1568-79 2016.7
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Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults. Reviewed
Yasuda T, Tsuzuki S, Kawazu M, Hayakawa F, Kojima S, Ueno T, Imoto N, Kohsaka S, Kunita A, Doi K, Sakura T, Yujiri T, Kondo E, Fujimaki K, Ueda Y, Aoyama Y, Ohtake S, Takita J, Sai E, Taniwaki M, Kurokawa M, Morishita S, Fukayama M, Kiyoi H, Miyazaki Y, Naoe T, Mano H.
Nat Genet. Vol. 48 ( 5 ) page： 569-74 2016.5
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Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients. Reviewed
Kihara R, Nagata Y, Kiyoi H, Kato T, Yamamoto E, Suzuki K, Chen F, Asou N, Ohtake S, Miyawaki S, Miyazaki Y, Sakura T, Ozawa Y, Usui N, Kanamori H, Kiguchi T, Imai K, Uike N, Kimura F, Kitamura K, Nakaseko C, Onizuka M, Takeshita A, Ishida F, Suzushima H, Kato Y, Miwa H, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Naoe T.
Leukemia Vol. 28 page： 1586-1595 2014
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Leukemic evolution of donor-derived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation. Reviewed
Yasuda T, Ueno T, Fukumura K, Yamato A, Ando M, Yamaguchi H, Soda M, Kawazu M, Sai E, Yamashita Y, Murata M, Kiyoi H, Naoe T, Mano H.
Leukemia Vol. 28 page： 426-428 2014
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Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment. Reviewed
Goto E, Tomita A, Hayakawa F, Atsumi A, Kiyoi H, Naoe T.
Blood Vol. 118 page： 1600-1609 2011
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KW-2449, a novel multi-kinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Reviewed
Shiotsu Y*, Kiyoi H*, Ishikawa Y, Tanizaki R, Shimizu M, Umehara H, Ishii K, Mori Y, Ozeki K, Minami Y, Abe A, Maeda H, Akiyama T, Kanda Y, Sato Y, Akinaga S, Naoe T.
Blood Vol. 114 page： 1607-1617 2009
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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies Reviewed
Yamamoto Y, Kiyoi H, Nakano Y, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Saito K, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Saito H, Ueda R, Ohno R, and Naoe T.
Blood Vol. 97 page： 2434-2439 2001
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Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Reviewed
Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, Asou N, Kuriyama K, Jinnai I, Shimazaki C, Akiyama H, Saito K, Oh H, Motoji T, Omoto E, Saito H, Ohno R, Ueda R.
Blood Vol. 93 page： 3074-3080 1999
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Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Reviewed
Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, Saito H, Naoe T.
Leukemia Vol. 12 page： 1333-1337 1998
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Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells Reviewed International journal
Kawashima Naomi, Ishikawa Yuichi, Kim Jeong Hui, Ushijima Yoko, Akashi Akimi, Yamaguchi Yohei, Hattori Hikaru, Nakashima Marie, Ikeno Seara, Kihara Rika, Nishiyama Takahiro, Morishita Takanobu, Watamoto Koichi, Ozawa Yukiyasu, Kitamura Kunio, Kiyoi Hitoshi
NATURE COMMUNICATIONS Vol. 13 ( 1 ) page： 1624 2022.3
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Frequent genetic alterations in immune checkpoint-related genes in intravascular large B-cell lymphoma Reviewed International journal
Shimada Kazuyuki, Yoshida Kenichi, Suzuki Yasuhiro, Iriyama Chisako, Inoue Yoshikage, Sanada Masashi, Kataoka Keisuke, Yuge Masaaki, Takagi Yusuke, Kusumoto Shigeru, Masaki Yasufumi, Ito Takahiko, Inagaki Yuichiro, Okamoto Akinao, Kuwatsuka Yachiyo, Nakatochi Masahiro, Shimada Satoko, Miyoshi Hiroaki, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Shiozawa Yusuke, Nannya Yasuhito, Okabe Asako, Kohno Kei, Atsuta Yoshiko, Ohshima Koichi, Nakamura Shigeo, Ogawa Seishi, Tomita Akihiro, Kiyoi Hitoshi
BLOOD Vol. 137 ( 11 ) page： 1491 - 1502 2021.3
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Allogeneic hematopoietic stem cell transplantation at the first remission for younger adults with FLT3-internal tandem duplication AML: The JALSG AML209-FLT3-SCT study. Reviewed International journal
Kawashima N, Ishikawa Y, Atsuta Y, Sawa M, Ozawa Y, Hayashi M, Kohno A, Tomita A, Maeda T, Sakaida E, Usuki K, Hagihara M, Kanamori H, Matsuoka H, Kobayashi M, Asou N, Ohtake S, Matsumura I, Miyazaki Y, Naoe T, Kiyoi H, Japan Adult Leukemia Study Group (JALSG).
Cancer science Vol. 111 ( 7 ) page： 2472 - 2481 2020.7
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Simple and early prediction of severe CAR-T-related adverse events after Axi-cel infusion by initial high fever. Reviewed International journal
Wakabayashi H, Terakura S, Ishigiwa K, Ohara F, Hirano S, Yokota H, Kuwano S, Furukawa K, Shimada K, Sato T, Hanajiri R, Kiyoi H
International journal of hematology 2025.2
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Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): long-term results of a multicentre, single-arm, phase 2 trial Reviewed International journal
Shimada, K; Yamaguchi, M; Kuwatsuka, Y; Matsue, K; Sato, K; Kusumoto, S; Nagai, H; Takizawa, J; Fukuhara, N; Nagafuji, K; Miyazaki, K; Ohtsuka, E; Okamoto, A; Sugita, Y; Uchida, T; Kayukawa, S; Wake, A; Ennishi, D; Kondo, Y; Meguro, A; Kin, Y; Minami, Y; Hashimoto, D; Nishiyama, T; Shimada, S; Masaki, Y; Okamoto, M; Atsuta, Y; Kiyoi, H; Suzuki, R; Nakamura, S; Kinoshita, T; Ennishi, D; Kondo, Y; Meguro, A; Kin, Y; Minami, Y; Hashimoto, D; Nishiyama, T; Shimada, S; Masaki, Y; Okamoto, M; Atsuta, Y; Kiyoi, H; Suzuki, R; Nakamura, S; Kinoshita, T
ECLINICALMEDICINE Vol. 80 page： 103078 2025.2
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Post-transplant TKIs for Ph+ ALL: practices to date and clinical significance. Reviewed International journal
Nishiwaki S, Terakura S, Morishita T, Goto T, Inagaki Y, Miyao K, Fukushima N, Hirano D, Tange N, Kurahashi S, Kuwatsuka Y, Kasai M, Iida H, Ozeki K, Sawa M, Nishida T, Kiyoi H
International journal of hematology 2025.1
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Sustained inhibition of CSF1R signaling augments antitumor immunity through inhibiting tumor-associated macrophages Reviewed International journal
Sato, T; Sugiyama, D; Koseki, J; Kojima, Y; Hattori, S; Sone, K; Nishinakamura, H; Ishikawa, T; Ishikawa, Y; Kato, T; Kiyoi, H; Nishikawa, H
JCI INSIGHT Vol. 10 ( 1 ) 2025.1
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Cullin-5 deficiency promotes chimeric antigen receptor T cell effector functions potentially via the modulation of JAK/STAT signaling pathway Reviewed International coauthorship International journal
Adachi, Y; Terakura, S; Osaki, M; Okuno, Y; Sato, Y; Sagou, K; Takeuchi, Y; Yokota, H; Imai, K; Steinberger, P; Leitner, J; Hanajiri, R; Murata, M; Kiyoi, H
NATURE COMMUNICATIONS Vol. 15 ( 1 ) page： 10376 2024.12
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Nelarabine-combined chemotherapy improves outcome of T-cell acute lymphoblastic leukemia but shows more severe neurotoxicity: JALSG T-ALL213-O Reviewed International journal
Hayakawa, F; Mori, N; Imai, K; Yokoyama, Y; Katsuoka, Y; Saito, T; Murayama, T; Yamazaki, E; Sato, S; Atsuta, Y; Ishikawa, Y; Sakaida, E; Hatta, Y; Matsumura, I; Miyazaki, Y; Kiyoi, H
CANCER SCIENCE 2024.11
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Clinical characteristics in adolescents and young adults with polycythemia vera and essential thrombocythemia in Japan Reviewed International journal
Sugimoto, Y; Nagaharu, K; Ohya, E; Ohishi, K; Tawara, I; Ito, T; Gotoh, A; Nakamae, M; Kimura, F; Koike, M; Kirito, K; Wada, H; Usuki, K; Tanaka, T; Mori, T; Wakita, S; Saito, TI; Saito, AM; Shimoda, K; Kurokawa, T; Tomita, A; Edahiro, Y; Hashimoto, Y; Kiyoi, H; Akashi, K; Matsumura, I; Takenaka, K; Komatsu, N
INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 120 ( 6 ) page： 684 - 693 2024.10