Faculty Profiles - KIYOI, Hitoshi

Papers - KIYOI, Hitoshi

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A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with FLT3 mutations. Reviewed Open Access

Yamaura T, Nakatani T, Uda K, Ogura H, Shin W, Kurokawa N, Saito K, Fujikawa N, Date T, Takasaki M, Terada D, Hirai A, Akashi A, Chen F, Adachi Y, Ishikawa Y, Hayakawa F, Hagiwara S, Naoe T, Kiyoi H.

Blood 2017.11

Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma. Reviewed

Shimada K, Shimada S, Sugimoto K, Nakatochi M, Suguro M, Hirakawa A, Hocking TD, Takeuchi I, Tokunaga T, Takagi Y, Sakamoto A, Aoki T, Naoe T, Nakamura S, Hayakawa F, Seto M, Tomita A, Kiyoi H.

Leukemia. Vol. 30 ( 7 ) page： 1568-79 2016.7

Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults. Reviewed

Yasuda T, Tsuzuki S, Kawazu M, Hayakawa F, Kojima S, Ueno T, Imoto N, Kohsaka S, Kunita A, Doi K, Sakura T, Yujiri T, Kondo E, Fujimaki K, Ueda Y, Aoyama Y, Ohtake S, Takita J, Sai E, Taniwaki M, Kurokawa M, Morishita S, Fukayama M, Kiyoi H, Miyazaki Y, Naoe T, Mano H.

Nat Genet. Vol. 48 ( 5 ) page： 569-74 2016.5

Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients. Reviewed

Kihara R, Nagata Y, Kiyoi H, Kato T, Yamamoto E, Suzuki K, Chen F, Asou N, Ohtake S, Miyawaki S, Miyazaki Y, Sakura T, Ozawa Y, Usui N, Kanamori H, Kiguchi T, Imai K, Uike N, Kimura F, Kitamura K, Nakaseko C, Onizuka M, Takeshita A, Ishida F, Suzushima H, Kato Y, Miwa H, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Naoe T.

Leukemia Vol. 28 page： 1586-1595 2014

Leukemic evolution of donor-derived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation. Reviewed

Yasuda T, Ueno T, Fukumura K, Yamato A, Ando M, Yamaguchi H, Soda M, Kawazu M, Sai E, Yamashita Y, Murata M, Kiyoi H, Naoe T, Mano H.

Leukemia Vol. 28 page： 426-428 2014

Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment. Reviewed Open Access

Goto E, Tomita A, Hayakawa F, Atsumi A, Kiyoi H, Naoe T.

Blood Vol. 118 page： 1600-1609 2011

KW-2449, a novel multi-kinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Reviewed

Shiotsu Y*, Kiyoi H*, Ishikawa Y, Tanizaki R, Shimizu M, Umehara H, Ishii K, Mori Y, Ozeki K, Minami Y, Abe A, Maeda H, Akiyama T, Kanda Y, Sato Y, Akinaga S, Naoe T.

Blood Vol. 114 page： 1607-1617 2009

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies Reviewed

Yamamoto Y, Kiyoi H, Nakano Y, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Saito K, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Saito H, Ueda R, Ohno R, and Naoe T.

Blood Vol. 97 page： 2434-2439 2001

Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Reviewed

Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, Asou N, Kuriyama K, Jinnai I, Shimazaki C, Akiyama H, Saito K, Oh H, Motoji T, Omoto E, Saito H, Ohno R, Ueda R.

Blood Vol. 93 page： 3074-3080 1999

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Reviewed

Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, Saito H, Naoe T.

Leukemia Vol. 12 page： 1333-1337 1998

Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells Reviewed International journal Open Access

Kawashima Naomi, Ishikawa Yuichi, Kim Jeong Hui, Ushijima Yoko, Akashi Akimi, Yamaguchi Yohei, Hattori Hikaru, Nakashima Marie, Ikeno Seara, Kihara Rika, Nishiyama Takahiro, Morishita Takanobu, Watamoto Koichi, Ozawa Yukiyasu, Kitamura Kunio, Kiyoi Hitoshi

NATURE COMMUNICATIONS Vol. 13 ( 1 ) page： 1624 2022.3

Frequent genetic alterations in immune checkpoint-related genes in intravascular large B-cell lymphoma Reviewed International journal Open Access

Shimada Kazuyuki, Yoshida Kenichi, Suzuki Yasuhiro, Iriyama Chisako, Inoue Yoshikage, Sanada Masashi, Kataoka Keisuke, Yuge Masaaki, Takagi Yusuke, Kusumoto Shigeru, Masaki Yasufumi, Ito Takahiko, Inagaki Yuichiro, Okamoto Akinao, Kuwatsuka Yachiyo, Nakatochi Masahiro, Shimada Satoko, Miyoshi Hiroaki, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Shiozawa Yusuke, Nannya Yasuhito, Okabe Asako, Kohno Kei, Atsuta Yoshiko, Ohshima Koichi, Nakamura Shigeo, Ogawa Seishi, Tomita Akihiro, Kiyoi Hitoshi

BLOOD Vol. 137 ( 11 ) page： 1491 - 1502 2021.3

Allogeneic hematopoietic stem cell transplantation at the first remission for younger adults with FLT3-internal tandem duplication AML: The JALSG AML209-FLT3-SCT study. Reviewed International journal Open Access

Kawashima N, Ishikawa Y, Atsuta Y, Sawa M, Ozawa Y, Hayashi M, Kohno A, Tomita A, Maeda T, Sakaida E, Usuki K, Hagihara M, Kanamori H, Matsuoka H, Kobayashi M, Asou N, Ohtake S, Matsumura I, Miyazaki Y, Naoe T, Kiyoi H, Japan Adult Leukemia Study Group (JALSG).

Cancer science Vol. 111 ( 7 ) page： 2472 - 2481 2020.7

CD79A/CD40 intracellular domain uses a 4-1BB-like metabolic pathway driven by cholesterol biosynthesis. Reviewed International journal Open Access

Takeuchi Y, Terakura S, Ishigiwa K, Julamanee J, Hirano S, Yokota H, Kuwano S, Hanajiri R, Kiyoi H

Journal for immunotherapy of cancer Vol. 14 ( 3 ) 2026.3

Percentage of CD56(+) monocytes at neutrophil engraftment is associated with the incidence of acute graft-versus-host disease. Reviewed International journal Open Access

Hashimoto K, Sato T, Ishikawa Y, Okuhiro Y, Sugiyama D, Zhang H, Ito S, Inagaki Y, Miyao K, Sawa M, Morishita T, Goto T, Nishida T, Fukushima N, Ozeki K, Hanajiri R, Terakura S, Nishikawa H, Kiyoi H

Annals of hematology Vol. 105 ( 4 ) 2026.3

Five-year interim analysis of J-SKI: an observational study of TKI discontinuation in patients with CML in Japan. Reviewed International journal Open Access

Takahashi N, Kimura S, Matsuki E, Ono T, Doki N, Iino M, Sawa M, Saburi Y, Murai K, Fujimaki K, Kurahashi S, Iriyama N, Onaka T, Sakaida E, Yoshida C, Sato K, Miyamoto T, Takaku T, Shiratsuchi M, Kimura F, Katagiri S, Yamamoto M, Saito AM, Kiyoi H, Matsumura I

International journal of hematology 2026.3

Impact of CD5 expression on outcomes for chimeric antigen receptor-T cell therapy in relapsed and refractory diffuse large B-cell lymphoma Reviewed International journal Open Access

Kawaguchi, T; Shimada, K; Furukawa, K; Kawamura, Y; Hanajiri, R; Terakura, S; Kiyoi, H

CYTOTHERAPY Vol. 28 ( 3 ) page： 102015 2026.3

Prospective observational study to assess the prognosis of patients with myeloproliferative neoplasms in Japan (MPN-15): results of baseline analysis. Reviewed International journal

Takenaka K, Ito T, Komatsu N, Yamaguchi H, Kirito K, Tomita A, Togano T, Tanaka T, Sugimoto Y, Murai K, Wada H, Kurokawa T, Koike M, Gotoh A, Maekawa T, Kubuki Y, Akagi T, Yamauchi T, Edahiro Y, Ikeda K, Kondo T, Tanaka H, Miyazaki Y, Saito TI, Shimoda K, Kada A, Saito AM, Kiyoi H, Akashi K, Matsumura I, Takaori A

International journal of hematology 2026.2

Antithrombotic Therapy on Antithrombin Resistance in a Mouse Model. Reviewed International journal

Suzuki N, Suzuki A, Tamura S, Tokumaru S, Notoh H, Takagi A, Suzuki S, Isotani A, Suzuki N, Okamoto S, Kanematsu T, Ikawa M, Hayakawa F, Kiyoi H, Kojima T, Matsushita T

Arteriosclerosis, thrombosis, and vascular biology 2026.1

VWF-T441N, a novel missense variant in the VWF D2 domain, exhibits impaired multimerization and deformed Weibel-Palade bodies. Reviewed International journal

Okamoto S, Tamura S, Suzuki A, Suzuki N, Kanematsu T, Suzuki N, Tomita M, Hayakawa F, Katsumi A, Kiyoi H, Kojima T, Matsushita T

Journal of thrombosis and haemostasis : JTH 2025.11

Dasatinib is superior to imatinib in adult Ph plus ALL: a propensity score-matched analysis of pooled JALSG trial data Reviewed International journal

Nishiwaki, S; Sugiura, I; Fujisawa, S; Hatta, Y; Atsuta, Y; Doki, N; Kurahashi, S; Ueda, Y; Dobashi, N; Maeda, T; Matsumura, I; Tanaka, M; Kako, S; Ichinohe, T; Fukuda, T; Ohtake, S; Ishikawa, Y; Miyazaki, Y; Sakaida, E; Maeda, Y; Yamauchi, T; Kiyoi, H; Japan Adult Leukemia Study Grp

INTERNATIONAL JOURNAL OF HEMATOLOGY 2025.8

Post-Diagnosis Hemorrhagic Events Are Strongly Associated With Poor Survival in Patients With Essential Thrombocythemia Reviewed International journal

Hashimoto, Y; Ito, T; Gotoh, A; Nakamae, M; Kimura, F; Koike, M; Kirito, K; Wada, H; Usuki, K; Tanaka, T; Mori, T; Wakita, S; Saito, TI; Kada, A; Saito, AM; Shimoda, K; Sugimoto, Y; Kurokawa, T; Tomita, A; Edahiro, Y; Kiyoi, H; Akashi, K; Matsumura, I; Takenaka, K; Komatsu, N

EJHAEM Vol. 6 ( 4 ) page： e70103 2025.8

Adjustment of low-dose ATG exposure improves outcomes in allogeneic hematopoietic stem cell transplantation: a prospective multicenter study Reviewed International journal

Kuwano, S; Terakura, S; Imai, K; Hirano, S; Yokota, H; Takeuchi, Y; Sato, T; Hanajiri, R; Sawa, M; Inagaki, Y; Sakai, T; Kurahashi, S; Nishida, T; Ozawa, Y; Imahashi, N; Ueki, T; Murata, M; Kiyoi, H

CYTOTHERAPY Vol. 27 ( 8 ) page： 962 - 972 2025.8

JAK-STAT-activated, fratricide-resistant CAR-T cells targeting membrane-bound TNF effectively treat AML and solid tumors Reviewed International journal

Nakashima, T; Ouchida, T; Ishikawa, Y; Ito, Y; Hayakawa, T; Yoshikawa, T; Zhang, HS; Kasuya, H; Li, Y; Matsukawa, T; Inoue, S; Iida, S; Kiyoi, H; Kagoya, Y

JOURNAL FOR IMMUNOTHERAPY OF CANCER Vol. 13 ( 7 ) 2025.7

Two-way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3 Reviewed International journal

Ueno, R; Terasaki, A; Imai, Y; Kimura, Y; Kojima, Y; Irie, M; Odaira, K; Noura, M; Okamoto, S; Yasuda, T; Tsuzuki, S; Kiyoi, H; Hayakawa, F

FEBS OPEN BIO 2025.7

Robust CAR T-cell expansion and superior outcomes in DLBCL patients in complete response at infusion Reviewed International journal

Hanajiri, R; Wakabayashi, H; Ishigiwa, K; Ohara, F; Hirano, S; Yokota, H; Kuwano, S; Furukawa, K; Shimada, K; Sato, T; Terakura, S; Kiyoi, H

BRITISH JOURNAL OF HAEMATOLOGY Vol. 207 ( 1 ) page： 180 - 188 2025.7

Induction of T-Cell Differentiation by KLF4 in T-Cell Acute Lymphoblastic Leukemia Cells Harboring Activating Mutation in NOTCH3 Reviewed International journal

Noura, M; Yasuda, T; Kiyoi, H; Hayakawa, F

FASEB JOURNAL Vol. 39 ( 10 ) page： e70613 2025.5

Development and optimization of Eva1 (MPZL2) targeting chimeric antigen receptor T cells. Reviewed International journal Open Access

Osaki M, Terakura S, Hirano S, Iwasa T, Hatanaka KC, Hatanaka Y, Sunagawa M, Kokuryo T, Adachi Y, Takeuchi Y, Hanajiri R, Sakanaka C, Murata M, Ebata T, Kiyoi H

Journal for immunotherapy of cancer Vol. 13 ( 5 ) 2025.5

Simple and early prediction of severe CAR-T-related adverse events after Axi-cel infusion by initial high fever. Reviewed International journal

Wakabayashi H, Terakura S, Ishigiwa K, Ohara F, Hirano S, Yokota H, Kuwano S, Furukawa K, Shimada K, Sato T, Hanajiri R, Kiyoi H

International journal of hematology 2025.2

Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): long-term results of a multicentre, single-arm, phase 2 trial Reviewed International journal

Shimada, K; Yamaguchi, M; Kuwatsuka, Y; Matsue, K; Sato, K; Kusumoto, S; Nagai, H; Takizawa, J; Fukuhara, N; Nagafuji, K; Miyazaki, K; Ohtsuka, E; Okamoto, A; Sugita, Y; Uchida, T; Kayukawa, S; Wake, A; Ennishi, D; Kondo, Y; Meguro, A; Kin, Y; Minami, Y; Hashimoto, D; Nishiyama, T; Shimada, S; Masaki, Y; Okamoto, M; Atsuta, Y; Kiyoi, H; Suzuki, R; Nakamura, S; Kinoshita, T; Ennishi, D; Kondo, Y; Meguro, A; Kin, Y; Minami, Y; Hashimoto, D; Nishiyama, T; Shimada, S; Masaki, Y; Okamoto, M; Atsuta, Y; Kiyoi, H; Suzuki, R; Nakamura, S; Kinoshita, T

ECLINICALMEDICINE Vol. 80 page： 103078 2025.2

Post-transplant TKIs for Ph+ ALL: practices to date and clinical significance. Reviewed International journal

Nishiwaki S, Terakura S, Morishita T, Goto T, Inagaki Y, Miyao K, Fukushima N, Hirano D, Tange N, Kurahashi S, Kuwatsuka Y, Kasai M, Iida H, Ozeki K, Sawa M, Nishida T, Kiyoi H

International journal of hematology 2025.1

Sustained inhibition of CSF1R signaling augments antitumor immunity through inhibiting tumor-associated macrophages Reviewed International journal

Sato, T; Sugiyama, D; Koseki, J; Kojima, Y; Hattori, S; Sone, K; Nishinakamura, H; Ishikawa, T; Ishikawa, Y; Kato, T; Kiyoi, H; Nishikawa, H

JCI INSIGHT Vol. 10 ( 1 ) 2025.1

Cullin-5 deficiency promotes chimeric antigen receptor T cell effector functions potentially via the modulation of JAK/STAT signaling pathway Reviewed International coauthorship International journal

Adachi, Y; Terakura, S; Osaki, M; Okuno, Y; Sato, Y; Sagou, K; Takeuchi, Y; Yokota, H; Imai, K; Steinberger, P; Leitner, J; Hanajiri, R; Murata, M; Kiyoi, H

NATURE COMMUNICATIONS Vol. 15 ( 1 ) page： 10376 2024.12

Nelarabine-combined chemotherapy improves outcome of T-cell acute lymphoblastic leukemia but shows more severe neurotoxicity: JALSG T-ALL213-O Reviewed International journal

Hayakawa, F; Mori, N; Imai, K; Yokoyama, Y; Katsuoka, Y; Saito, T; Murayama, T; Yamazaki, E; Sato, S; Atsuta, Y; Ishikawa, Y; Sakaida, E; Hatta, Y; Matsumura, I; Miyazaki, Y; Kiyoi, H

CANCER SCIENCE 2024.11

Clinical characteristics in adolescents and young adults with polycythemia vera and essential thrombocythemia in Japan Reviewed International journal

Sugimoto, Y; Nagaharu, K; Ohya, E; Ohishi, K; Tawara, I; Ito, T; Gotoh, A; Nakamae, M; Kimura, F; Koike, M; Kirito, K; Wada, H; Usuki, K; Tanaka, T; Mori, T; Wakita, S; Saito, TI; Saito, AM; Shimoda, K; Kurokawa, T; Tomita, A; Edahiro, Y; Hashimoto, Y; Kiyoi, H; Akashi, K; Matsumura, I; Takenaka, K; Komatsu, N

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 120 ( 6 ) page： 684 - 693 2024.10

Misleading antigenic von Willebrand factor levels in acquired von Willebrand syndrome secondary to monoclonal gammopathy of undetermined significance Reviewed International journal

Okamoto, S; Suzuki, A; Tamura, S; Suzuki, N; Kanematsu, T; Suzuki, N; Kawaguchi, Y; Katsumi, A; Hayakawa, F; Kiyoi, H; Kojima, T; Matsushita, T

INTERNATIONAL JOURNAL OF HEMATOLOGY 2024.10

Spheroid culture to select theoretical therapeutic drugs in intravascular large B-cell lymphoma Reviewed International journal

Takai, M; Shimada, K; Furukawa, K; Yamaga, Y; Yoshiyama, S; Kagaya, Y; Suzuki, T; Hayashi, K; Shimada, S; Karube, K; Kiyoi, H

CANCER SCIENCE 2024.10

Newly diagnosed multiple myeloma with bleeding and coagulation abnormalities caused by a thrombin-inhibiting substance Reviewed International journal

Ohara, F; Suzuki, A; Suzuki, N; Kanematsu, T; Okamoto, S; Tamura, S; Kiyoi, H; Matsushita, T; Katsumi, A

INTERNATIONAL JOURNAL OF HEMATOLOGY 2024.9

Recent advances in AML with mutated NPM1 Invited Reviewed International journal

Ishikawa, Y; Ushijima, Y; Kiyoi, H

INTERNATIONAL JOURNAL OF HEMATOLOGY 2024.8

Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms: JSH-MPN-R18 subanalysis (JUL, 10.1007/s00277-024-05898-3, 2024) Reviewed International journal

Nagaharu, K; Ohya, E; Edahiro, Y; Hashimoto, Y; Ito, T; Gotoh, A; Nakamae, M; Kimura, F; Koike, M; Kirito, K; Wada, H; Usuki, K; Tanaka, T; Mori, T; Wakita, S; Saito, TI; Saito, AM; Shimoda, K; Kurokawa, T; Tomita, A; Kiyoi, H; Akashi, K; Matsumura, I; Takenaka, K; Komatsu, N; Ohishi, K; Tawara, I; Sugimoto, Y

ANNALS OF HEMATOLOGY 2024.8

Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms: JSH-MPN-R18 subanalysis Reviewed International journal

ANNALS OF HEMATOLOGY Vol. 103 ( 9 ) page： 3535 - 3541 2024.7

Initiating-clone analysis in patients with acute myeloid leukemia secondary to essential thrombocythemia Reviewed International journal

Ushijima, Y; Naruse, S; Ishikawa, Y; Kawashima, N; Sanada, M; Nakashima, M; Kim, JH; Terakura, S; Kihara, R; Watamoto, K; Nishiyama, T; Kitamura, K; Matsushita, T; Kiyoi, H

SCIENTIFIC REPORTS Vol. 14 ( 1 ) page： 15906 2024.7

Nilotinib vs. Dasatinib in Achieving MR4.5 for de novo Chronic Myeloid Leukemia: the Randomized JALSG CML212 Study. Reviewed International journal

Matsumura I, Ohtake S, Atsuta Y, Kurata M, Minami Y, Takahashi N, Nakaseko C, Iriyama N, Fujimaki K, Kakihana K, Ogasawara Y, Ono T, Okada M, Tauchi T, Miyamoto T, Ohnishi K, Sakaida E, Fujisawa S, Kobayashi Y, Asou N, Naoe T, Kiyoi H, Miyazaki Y

Blood advances 2024.7

NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation Reviewed International journal

Noura, M; Tomita, S; Yasuda, T; Tsuzuki, S; Kiyoi, H; Hayakawa, F

CANCER MEDICINE Vol. 13 ( 13 ) page： e7445 2024.7

RGS1 and CREB5 are direct and common transcriptional targets of ZNF384-fusion proteins Reviewed International journal

Yamada, C; Okada, K; Odaira, K; Tokoro, M; Iwamoto, E; Sanada, M; Noura, M; Okamoto, S; Yasuda, T; Tsuzuki, S; Kiyoi, H; Hayakawa, F

CANCER MEDICINE Vol. 13 ( 14 ) page： e7471 2024.7

Human iPSC-derived CD4+Treg-like cells engineered with chimeric antigen receptors control GvHD in a xenograft model Reviewed International journal

Yano, H; Koga, K; Sato, T; Shinohara, T; Iriguchi, S; Matsuda, A; Nakazono, K; Shioiri, M; Miyake, Y; Kassai, Y; Kiyoi, H; Kaneko, S

CELL STEM CELL Vol. 31 ( 6 ) page： 795 - 802.e6 2024.6

Phase II study in children and adults under 40 years with newly diagnosed Langerhans cell histiocytosis: protocol for an LCH-19-MSMFB clinical trial in Japan Reviewed International journal

Ono, R; Sakamoto, K; Kudo, K; Sato, A; Kudo, K; Fujino, H; Kawahara, Y; Hashimoto, H; Doi, T; Yanagisawa, R; Kawamata, T; Miyazaki, O; Nakazawa, A; Ota, Y; Kanegane, H; Nakazawa, Y; Horibe, K; Saito, AM; Manabe, A; Usuki, K; Kiyoi, H; Morimoto, A; Tojo, A; Shioda, Y

BMJ OPEN Vol. 14 ( 6 ) page： e084159 2024.6

A phase 1/2 study of NS-87/CPX-351 (cytarabine and daunorubicin liposome) in Japanese patients with high-risk acute myeloid leukemia Reviewed International journal

Usuki, K; Miyamoto, T; Yamauchi, T; Ando, K; Ogawa, Y; Onozawa, M; Yamauchi, T; Kiyoi, H; Yokota, A; Ikezoe, T; Katsuoka, Y; Takada, S; Aotsuka, N; Morita, Y; Ishikawa, T; Asada, N; Ota, S; Dohi, A; Morimoto, K; Imai, S; Kishimoto, U; Akashi, K; Miyazaki, Y

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 119 ( 6 ) page： 647 - 659 2024.6

Clonal evolution process from essential thrombocythemia to acute myeloid leukemia in the original patient from whom the CALR-mutated Marimo cell line was established. Reviewed International journal

Ushijima Y, Ishikawa Y, Nishiyama T, Kawashima N, Kanamori T, Sanada M, Kiyoi H

Nagoya journal of medical science Vol. 86 ( 2 ) page： 326 - 332 2024.5

Novel CSF1R inhibitor, FF-10101, strongly inhibit tumor-associated macrophages and improve anti-tumor response Reviewed International journal

Sato, T; Sugiyama, D; Kojima, Y; Hattori, S; Sone, K; Ishikawa, Y; Nishikawa, H; Kiyoi, H

CANCER SCIENCE Vol. 115 page： 41 - 41 2024.3

Utility of allogeneic stem cell transplantation for adult Ph plus ALL with complete molecular remission Reviewed International journal

AMERICAN JOURNAL OF HEMATOLOGY 2024.2

Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia Reviewed International journal

Noura, M; Matsuo, H; Yasuda, T; Tsuzuki, S; Kiyoi, H; Hayakawa, F

ONCOGENE Vol. 43 ( 6 ) page： 447 - 456 2024.2

Real-world data of MDS and CMML in Japan: results of JALSG clinical observational study-11 (JALSG-CS-11) Reviewed International journal

Usuki, K; Ohtake, S; Honda, S; Matsuda, M; Wakita, A; Nawa, Y; Takase, K; Maeda, A; Sezaki, N; Yokoyama, H; Takada, S; Hirano, D; Tomikawa, T; Sumi, M; Yano, S; Handa, H; Ota, S; Fujita, H; Fujimaki, K; Mugitani, A; Kojima, K; Kajiguchi, T; Fujimoto, K; Asou, N; Usui, N; Ishikawa, Y; Katsumi, A; Matsumura, I; Miyazaki, Y; Kiyoi, H

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 119 ( 2 ) page： 130 - 145 2024.2

Epstein-Barr virus lytic gene BNRF1 promotes B-cell lymphomagenesis via IFI27 upregulation Reviewed International journal

Sagou, K; Sato, Y; Okuno, Y; Watanabe, T; Inagaki, T; Motooka, Y; Toyokuni, S; Murata, T; Kiyoi, H; Kimura, H

PLOS PATHOGENS Vol. 20 ( 2 ) page： e1011954 2024.2

Clonal hematopoiesis of a novel dic(18;20) clone following allogeneic hematopoietic stem cell transplantation Reviewed International journal

Ito, M; Fukushima, N; Fujii, T; Numata, M; Morikawa, S; Kawamura, Y; Goto, M; Kohno, A; Imahashi, N; Yasuda, T; Sanada, M; Ishikawa, Y; Kiyoi, H; Ozeki, K

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 119 ( 1 ) page： 80 - 87 2024.1

Real-world data of AML in Japan: results of JALSG clinical observational study-11 (JALSG-CS-11) Reviewed International journal

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 119 ( 1 ) page： 24 - 38 2024.1

Outcomes of transplant-eligible patients with myelodysplastic syndrome with excess blasts registered in an observational study: The JALSG-CS11-MDS-SCT Reviewed International journal

Nakagawa, N; Ishiyama, K; Usuki, K; Takada, S; Tomikawa, T; Handa, H; Katsuoka, Y; Hirano, D; Sezaki, N; Sumi, M; Fujisawa, S; Taniguchi, Y; Mugitani, A; Yoshimura, T; Ohtsuka, E; Takase, K; Suehiro, Y; Ota, S; Kajiguchi, T; Maeda, T; Yamamoto, M; Ohtake, S; Katsumi, A; Kiyoi, H; Matsumura, I; Miyazaki, Y

ANNALS OF HEMATOLOGY Vol. 103 ( 1 ) page： 307 - 320 2024.1

Dual CAR-T cells targeting CD19 and CD37 are effective in target antigen loss B cell tumor models. Reviewed

Imai K, Takeuchi Y, Terakura S, Okuno S, Adachi Y, Osaki M, Umemura K, Hanajiri R, Shimada K, Murata M, Kiyoi H

Molecular cancer therapeutics 2023.10

Antibody response after third dose of COVID-19 mRNA vaccination in allogeneic hematopoietic stem cell transplant recipients is comparable to that in healthy counterparts Reviewed International journal Open Access

Takagi Erina, Terakura Seitaro, Fujigaki Hidetsugu, Okamoto Akinao, Miyao Kotaro, Sawa Masashi, Morishita Takanobu, Goto Tatsunori, Ozawa Yukiyasu, Nishida Tetsuya, Fukushima Nobuaki, Ozeki Kazutaka, Hanajiri Ryo, Saito Kuniaki, Murata Makoto, Tomita Akihiro, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 118 ( 4 ) page： 462 - 471 2023.10

Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation. Reviewed International journal Open Access

Kurayoshi K, Takase Y, Ueno M, Ohta K, Fuse K, Ikeda S, Watanabe T, Nishida Y, Horike SI, Hosomichi K, Ishikawa Y, Tadokoro Y, Kobayashi M, Kasahara A, Jing Y, Shoulkamy MI, Meguro-Horike M, Kojima K, Kiyoi H, Sugiyama H, Nagase H, Tajima A, Hirao A

Cell death & disease Vol. 14 ( 9 ) page： 642 2023.9

Improved long-term net survival after allogeneic hematopoietic cell transplantation in patients with hematologic malignancies over two decades. Reviewed International journal

Ohbiki M, Ito Y, Inamoto Y, Miyamura K, Uchida N, Fukuda T, Fujiwara H, Nishida T, Hayashi M, Tanaka M, Kawakita T, Ikegame K, Katayama Y, Ara T, Ichinohe T, Kiyoi H, Matsuo K, Atsuta Y

Transplantation and cellular therapy 2023.9

Clinicopathological characteristics associated with the engraftment of patient lymphoma cells in NOG mice Reviewed International journal Open Access

Sahashi Satomi, Shimada Kazuyuki, Takagi Yusuke, Aoki Tomohiro, Kunou Shunsuke, Sakamoto Akihiko, Murase Atsushi, Furukawa Katsuya, Kagaya Yusuke, Yamaga Yusuke, Takai Mika, Tokuyama Kiyonobu, Shimada Satoko, Nakamura Shigeo, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 118 ( 2 ) page： 221 - 230 2023.8

EBF1-JAK2 inhibits the PAX5 function through physical interaction with PAX5 and kinase activity Reviewed International journal

Kojima Yukino, Kawashima Fumika, Yasuda Takahiko, Odaira Koya, Inagaki Yuichiro, Yamada Chiharu, Muraki Ami, Noura Mina, Okamoto Shuichi, Tamura Shogo, Iwamoto Eisuke, Sanada Masashi, Matsumura Itaru, Miyazaki Yasushi, Kojima Tetsuhito, Kiyoi Hitoshi, Tsuzuki Shinobu, Hayakawa Fumihiko

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 118 ( 1 ) page： 65 - 74 2023.7

High-risk Combinations of Additional Chromosomal Abnormalities in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia: JALSG Ph plus ALL TKI-SCT Study Open Access

Nishiwaki Satoshi, Sugiura Isamu, Fujisawa Shin, Hatta Yoshihiro, Atsuta Yoshiko, Doki Noriko, Kurahashi Shingo, Ueda Yasunori, Dobashi Nobuaki, Maeda Tomoya, Taniguchi Yasuhiro, Tanaka Masatsugu, Kako Shinichi, Ichinohe Tatsuo, Fukuda Takahiro, Ohtake Shigeki, Ishikawa Yuichi, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi

HEMASPHERE Vol. 7 ( 6 ) page： e899 2023.6

Nelarabine, intensive L-asparaginase, and protracted intrathecal therapy for newly diagnosedT-cell acute lymphoblastic leukaemia in children and young adults (ALL-T11): a nationwide, multicenter, phase 2 trial including randomisation in the very high-risk group Reviewed International journal

Sato Atsushi, Hatta Yoshihiro, Imai Chihaya, Oshima Koichi, Okamoto Yasuhiro, Deguchi Takao, Hashii Yoshiko, Fukushima Takashi, Hori Toshinori, Kiyokawa Nobutaka, Kato Motohiro, Saito Shoji, Anami Kenichi, Sakamoto Tatsuhiro, Kosaka Yoshiyuki, Suenobu Souichi, Imamura Toshihiko, Kada Akiko, Saito Akiko M., Manabe Atsushi, Kiyoi Hitoshi, Matsumura Itaru, Koh Katsuyoshi, Watanabe Arata, Miyazaki Yasushi, Horibe Keizo

LANCET HAEMATOLOGY Vol. 10 ( 6 ) page： 419 - 432 2023.6

Autologous peripheral blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia is safe but poses challenges for long-term maintenance of molecular remission: Results of the Auto-Ph17 study. Reviewed International journal Open Access

Nishiwaki S, Sugiura I, Sato T, Kobayashi M, Osaki M, Sawa M, Adachi Y, Okabe M, Saito S, Morishita T, Kohno A, Nishiyama T, Iida H, Kurahashi S, Kuwatsuka Y, Sugiyama D, Ito S, Nishikawa H, Kiyoi H

EJHaem Vol. 4 ( 2 ) page： 358 - 369 2023.5

A never-ending FLT3 story Invited Reviewed International journal Open Access

Kiyoi, H

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 85 ( 1 ) page： 27 - 29 2023.2

BCL6 inhibition ameliorates resistance to ruxolitinib in CRLF2-rearranged acute lymphoblastic leukemia Reviewed International journal Open Access

Tsuzuki Shinobu, Yasuda Takahiko, Goto Hiroaki, Maeda Naoko, Akahane Koshi, Inukai Takeshi, Yamamoto Hideyuki, Karnan Sivasundaram, Ota Akinobu, Hyodo Toshinori, Konishi Hiroyuki, Hosokawa Yoshitaka, Kiyoi Hitoshi, Hayakawa Fumihiko

HAEMATOLOGICA Vol. 108 ( 2 ) page： 394 - 408 2023.2

The usefulness of tranexamic acid for bleeding symptoms of chronic consumptive coagulopathy complicated by aortic disease: a single-institute, retrospective study of 14 patients Reviewed International journal Open Access

Suzuki Naruko, Suzuki Nobuaki, Kawaguchi Yuka, Okamoto Shuichi, Kanematsu Takeshi, Katsumi Akira, Suzuki Atsuo, Tamura Shogo, Kojima Tetsuhito, Kiyoi Hitoshi, Matsushita Tadashi

THROMBOSIS JOURNAL Vol. 21 ( 1 ) page： 10 2023.1

[Cellular kinetics and outcome of tisagenlecleucel for diffuse large B-cell lymphoma]. Reviewed

Hanajiri R, Furukawa K, Nakashima M, Ushijima Y, Shimada K, Ishikawa Y, Terakura S, Murata M, Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology Vol. 64 ( 3 ) page： 167 - 174 2023

Functional inhibition of MEF2 by C/EBP is a possible mechanism of leukemia development by CEBP-IGH fusion gene Reviewed International journal Open Access

Odaira Koya, Yasuda Takahiko, Okada Kentaro, Shimooka Takuya, Kojima Yukino, Noura Mina, Tamura Shogo, Kurahashi Shingo, Iwamoto Eisuke, Sanada Masashi, Matsumura Itaru, Miyazaki Yasushi, Kojima Tetsuhito, Kiyoi Hitoshi, Tsuzuki Shinobu, Hayakawa Fumihiko

CANCER SCIENCE Vol. 114 ( 3 ) page： 781 - 792 2022.11

Methods for confirming the safety of radiation therapy in patients with left ventricular assist device: a case of extranodal NK/T-cell lymphoma, nasal type Reviewed International journal

Oishi Hideo, Kondo Toru, Kawamura Mariko, Shimada Kazuyuki, Mutsuga Masato, Kurokawa Takashi, Kuwayama Tasuku, Hiraiwa Hiroaki, Morimoto Ryota, Okumura Takahiro, Nishida Tetsuya, Kiyoi Hitoshi, Naganawa Shinji, Usui Akihiko, Murohara Toyoaki

JOURNAL OF ARTIFICIAL ORGANS Vol. 25 ( 3 ) page： 274 - 278 2022.9

Prospective comparison of 5-and 7-day administration of azacitidine for myelodysplastic syndromes: a JALSG MDS212 trial Reviewed International journal

Miyazaki Yasushi, Kiguchi Toru, Sato Shinya, Usuki Kensuke, Ishiyama Ken, Ito Yoshikazu, Suzuki Takahiro, Taguchi Jun, Chiba Shigeru, Dobashi Nobuaki, Tomita Akihiro, Harada Hironori, Handa Hiroshi, Horiike Shigeo, Maeda Tomoya, Matsuda Mitsuhiro, Ichikawa Motoshi, Hata Tomoko, Honda Sumihisa, Iyama Satoshi, Suzushima Hitoshi, Moriuchi Yukiyoshi, Kurokawa Toshiro, Yokota Kenichi, Ohtake Shigeki, Yamauchi Takahiro, Matsumura Itaru, Kiyoi Hitoshi, Naoe Tomoki

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 116 ( 2 ) page： 228 - 238 2022.8

VWF-Gly2752Ser, a novel non-cysteine substitution variant in the CK domain, exhibits severe secretory impairment by hampering C-terminal dimer formation Reviewed International journal Open Access

Okamoto Shuichi, Tamura Shogo, Sanda Naomi, Odaira Koya, Hayakawa Yuri, Mukaide Masato, Suzuki Atsuo, Kanematsu Takeshi, Hayakawa Fumihiko, Katsumi Akira, Kiyoi Hitoshi, Kojima Tetsuhito, Matsushita Tadashi, Suzuki Nobuaki

JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 20 ( 8 ) page： 1784 - 1796 2022.8

Real-world treatment patterns and clinical outcomes in patients with AML in Japan who were ineligible for first-line intensive chemotherapy Reviewed International coauthorship International journal

Yoshida Chikashi, Kondo Takeshi, Ito Tomoki, Kizaki Masahiro, Yamamoto Kazuhiko, Miyamoto Toshihiro, Morita Yasuyoshi, Eto Tetsuya, Katsuoka Yuna, Takezako Naoki, Uoshima Nobuhiko, Imada Kazunori, Ando Jun, Komeno Takuya, Mori Akio, Ishikawa Yuichi, Satake Atsushi, Watanabe Junichi, Kawakami Yoshiko, Morita Tetsuo, Taneike Ikue, Nakayama Masahiko, Duan Yinghui, Garbayo Guijarro Belen, Delgado Alexander, Llamas Cynthia, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 116 ( 1 ) page： 89 - 101 2022.7

Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases Reviewed International coauthorship International journal Open Access

Dai Yu-Ting, Zhang Fan, Fang Hai, Li Jian-Feng, Lu Gang, Jiang Lu, Chen Bing, Mao Dong-Dong, Liu Yuan-Fang, Wang Jin, Peng Li-Jun, Feng Chong, Chen Hai-Feng, Mu Jun-Xi, Zhang Qun-Ling, Wang Hao, Ariffin Hany, Moy Tan Ah, Wang Jing-Han, Lou Yin-Jun, Chen Su-Ning, Wang Qian, Liu Hong, Shan Zhe, Matsumura Itaru, Miyazaki Yasushi, Yasuda Takahiko, Dou Li-Ping, Yan Xiao-jing, Yan Jin-Song, Yeoh Allen Eng-Juh, Wu De-Pei, Kiyoi Hitoshi, Hayakawa Fumihiko, Jin Jie, Wang Sheng-Yue, Sun Xiao-Jian, Mi Jian-Qing, Chen Zhu, Huang Jin-Yan, Chen Sai-Juan

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 119 ( 15 ) page： e2120787119 2022.4

Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations Reviewed International journal Open Access

Yasuda Takahiko, Sanada Masashi, Kawazu Masahito, Kojima Shinya, Tsuzuki Shinobu, Ueno Hiroo, Iwamoto Eisuke, Iijima-Yamashita Yuka, Yamada Tomomi, Kanamori Takashi, Nishimura Rieko, Kuwatsuka Yachiyo, Takada Satoru, Tanaka Masatsugu, Ota Shuichi, Dobashi Nobuaki, Yamazaki Etsuko, Hirose Asao, Murayama Tohru, Sumi Masahiko, Sato Shinya, Tange Naoyuki, Nakamura Yukinori, Katsuoka Yuna, Sakaida Emiko, Kawamata Toyotaka, Iida Hiroatsu, Shiraishi Yuichi, Nannya Yasuhito, Ogawa Seishi, Taniwaki Masafumi, Asou Norio, Hatta Yoshihiro, Kiyoi Hitoshi, Matsumura Itaru, Horibe Keizo, Mano Hiroyuki, Naoe Tomoki, Miyazaki Yasushi, Hayakawa Fumihiko

BLOOD Vol. 139 ( 12 ) page： 1850 - 1862 2022.3

Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline Reviewed International journal Open Access

Iwama Shintaro, Kobayashi Tomoko, Yasuda Yoshinori, Okuji Takayuki, Ito Masaaki, Ando Masahiko, Zhou Xin, Yamagami Ayana, Onoue Takeshi, Kawaguchi Yohei, Miyata Takashi, Sugiyama Mariko, Takagi Hiroshi, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Wakahara Keiko, Yokota Kenji, Kato Masashi, Nishio Naoki, Tanaka Chie, Miyata Kazushi, Ogura Atsushi, Ito Takanori, Sawada Tsunaki, Shimokata Tomoya, Niimi Kaoru, Ohka Fumiharu, Ishigami Masatoshi, Gotoh Momokazu, Hashimoto Naozumi, Saito Ryuta, Kiyoi Hitoshi, Kajiyama Hiroaki, Ando Yuichi, Hibi Hideharu, Sone Michihiko, Akiyama Masashi, Kodera Yasuhiro, Arima Hiroshi

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM Vol. 107 ( 4 ) page： E1620 - E1630 2022.3

Downregulation of HLA class II is associated with relapse after allogeneic stem cell transplantation and alters recognition by antigen-specific T cells Reviewed International journal

Adachi Yoshitaka, Sakai Toshiyasu, Terakura Seitaro, Shiina Takashi, Suzuki Shingo, Hamana Hiroshi, Kishi Hiroyuki, Sasazuki Takehiko, Arase Hisashi, Hanajiri Ryo, Goto Tatsunori, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 115 ( 3 ) page： 371 - 381 2022.3

Decision Analysis for Unrelated Bone Marrow Transplantation or Immediate Cord Blood Transplantation for Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in First Remission Reviewed International journal Open Access

Kako Shinichi, Hayakawa Fumihiko, Miyamura Koichi, Tanaka Junji, Imai Kiyotoshi, Kanda Junya, Morishima Satoko, Uchida Naoyuki, Doki Noriko, Ikegame Kazuhiro, Ozawa Yukiyasu, Takada Satoru, Usui Noriko, Ohtake Shigeki, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Ichinohe Tatsuo, Fukuda Takahiro, Atsuta Yoshiko, Kanda Yoshinobu

TRANSPLANTATION AND CELLULAR THERAPY Vol. 28 ( 3 ) page： 161.e1 - 161.e10 2022.3

Immune effects of TKI altered immune responses after stopping TKI treatment and affected treatment-free remission rate Reviewed International journal

Fujioka Yuki, Takahashi Naoto, Atsuta Yoshiko, Minami Yosuke, Kiyoi Hitoshi, Miyazaki Yasushi, Matsumura Itaru

CANCER SCIENCE Vol. 113 page： 1712 - 1712 2022.2

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia Reviewed International journal Open Access

Tsuzuki Shinobu, Yasuda Takahiko, Kawazu Masahito, Ueno Toshihide, Karnan Sivasundaram, Ota Akinobu, Sanada Masashi, Nagai Hirokazu, Tomita Akihiro, Takahashi Yoshiyuki, Miyazaki Yasushi, Matsumura Itaru, Kiyoi Hitoshi, Hosokawa Yoshitaka, Mano Hiroyuki, Hayakawa Fumihiko

CANCER SCIENCE Vol. 113 page： 1236 - 1236 2022.2

Regulatory T Cell as a Biomarker of Treatment-Free Remission in Patients with Chronic Myeloid Leukemia Reviewed International journal Open Access

Fujioka Yuki, Sugiyama Daisuke, Matsumura Itaru, Minami Yosuke, Miura Masatomo, Atsuta Yoshiko, Ohtake Shigeki, Kiyoi Hitoshi, Miyazaki Yasushi, Nishikawa Hiroyoshi, Takahashi Naoto

CANCERS Vol. 13 ( 23 ) 2021.12

Optimal treatment for Philadelphia-negative acute lymphoblastic leukemia in first remission in the era of high-intensity chemotherapy Reviewed International journal

Kako Shinichi, Hayakawa Fumihiko, Imai Kiyotoshi, Tanaka Junji, Mizuta Shuichi, Nishiwaki Satoshi, Kanamori Heiwa, Mukae Junichi, Ozawa Yukiyasu, Kondo Tadakazu, Fukuda Takahiro, Ichinohe Tatsuo, Ota Shuichi, Tanaka Yoshinori, Murayama Tohru, Kurahashi Shingo, Sakura Toru, Usui Noriko, Ohtake Shigeki, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Atsuta Yoshiko

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 114 ( 5 ) page： 608 - 619 2021.11

Current progress and future perspectives of research on intravascular large B-cell lymphoma Invited Reviewed International journal Open Access

Shimada Kazuyuki, Kiyoi Hitoshi

CANCER SCIENCE Vol. 112 ( 10 ) page： 3953 - 3961 2021.10

Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival Reviewed International journal Open Access

Julamanee Jakrawadee, Terakura Seitaro, Umemura Koji, Adachi Yoshitaka, Miyao Kotaro, Okuno Shingo, Takagi Erina, Sakai Toshiyasu, Koyama Daisuke, Goto Tatsunori, Hanajiri Ryo, Hudecek Michael, Steinberger Peter, Leitner Judith, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

MOLECULAR THERAPY Vol. 29 ( 9 ) page： 2677 - 2690 2021.9

Efficacy and safety of blinatumomab: Post hoc pooled analysis in Asian adults with relapsed/refractory B-cell precursor acute lymphoblastic leukemia Reviewed International coauthorship International journal Open Access

Kobayashi Yukio, Oh Iekuni, Miyamoto Toshihiro, Lee Won-Sik, Iida Hiroatsu, Minami Hironobu, Maeda Yoshinobu, Jang Jun Ho, Yoon Sung-Soo, Yeh Su-Peng, Tran Qui, Morris Joan, Franklin Janet, Kiyoi Hitoshi

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY 2021.6

Spacer Length Modification Facilitates Discrimination between Normal and Neoplastic Cells and Provides Clinically Relevant CD37 CAR T Cells Reviewed International journal Open Access

Okuno Shingo, Adachi Yoshitaka, Terakura Seitaro, Julamanee Jakrawadee, Sakai Toshiyasu, Umemura Koji, Miyao Kotaro, Goto Tatsunori, Murase Atsushi, Shimada Kazuyuki, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

JOURNAL OF IMMUNOLOGY Vol. 206 ( 12 ) page： 2862 - 2874 2021.6

Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma Reviewed International journal Open Access

Kunou Shunsuke, Shimada Kazuyuki, Takai Mika, Sakamoto Akihiko, Aoki Tomohiro, Hikita Tomoya, Kagaya Yusuke, Iwamoto Eisuke, Sanada Masashi, Shimada Satoko, Hayakawa Fumihiko, Oneyama Chitose, Kiyoi Hitoshi

ONCOGENE Vol. 40 ( 23 ) page： 3989 - 4003 2021.6

Phase I clinical trial of intra-bone marrow cotransplantation of mesenchymal stem cells in cord blood transplantation Reviewed International journal Open Access

Goto Tatsunori, Murata Makoto, Nishida Tetsuya, Terakura Seitaro, Kamoshita Sonoko, Ishikawa Yuichi, Ushijima Yoko, Adachi Yoshiya, Suzuki Satoshi, Kato Katsuyoshi, Hirakawa Akihiro, Nishiwaki Satoshi, Nishio Nobuhiro, Takahashi Yoshiyuki, Kodera Yoshihisa, Matsushita Tadashi, Kiyoi Hitoshi

STEM CELLS TRANSLATIONAL MEDICINE Vol. 10 ( 4 ) page： 542 - 553 2021.4

Combination of clofarabine, etoposide, and cyclophosphamide in adult relapsed/refractory acute lymphoblastic leukemia: a phase 1/2 dose-escalation study by the Japan Adult Leukemia Study Group Reviewed International journal

Saito Takeshi, Hatta Yoshihiro, Hayakawa Fumihiko, Takahashi Tsutomu, Hagihara Maki, Iida Hiroatsu, Minauchi Koichiro, Yamazaki Etsuko, Sugiura Isamu, Murayama Tohru, Sakura Toru, Mori Naoki, Imai Kiyotoshi, Yahagi Yuichi, Atsuta Yoshiko, Saito Akiko Moriya, Hirakawa Akihiro, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 113 ( 3 ) page： 395 - 403 2021.3

Machine learning-aided risk stratification in Philadelphia chromosome-positive acute lymphoblastic leukemia Open Access

Nishiwaki Satoshi, Sugiura Isamu, Koyama Daisuke, Ozawa Yukiyasu, Osaki Masahide, Ishikawa Yuichi, Kiyoi Hitoshi

BIOMARKER RESEARCH Vol. 9 ( 1 ) page： 13 2021.2

Impact of variation in reagent combinations for one-stage clotting assay on assay discrepancy in nonsevere haemophilia A Reviewed International journal

Suzuki Atsuo, Suzuki Nobuaki, Kanematsu Takeshi, Okamoto Shuichi, Tamura Shogo, Kikuchi Ryosuke, Katsumi Akira, Kiyoi Hitoshi, Kojima Tetsuhito, Matsushita Tadashi

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY Vol. 43 ( 1 ) page： 131 - 138 2021.2

Myh9 R702C is associated with erythroid abnormality with splenomegaly in mice Reviewed International journal Open Access

Kanematsu, T; Suzuki, N; Tamura, S; Suzuki, A; Ishikawa, Y; Katsumi, A; Kiyoi, H; Saito, H; Kunishima, S; Kojima, T; Matsushita, T

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 83 ( 1 ) page： 75 - 86 2021.2

Exosomes derived from cancer associated fibroblasts induce a resistance to histone deacetylase inhibitors in lymphoma Reviewed International journal

Kagaya Yusuke, Shimada Kazuyuki, Kunou Shunsuke, Hikita Tomoya, Sakamoto Akihiko, Hayakawa Fumihiko, Oneyama Chitose, Kiyoi Hitoshi

CANCER SCIENCE Vol. 112 page： 370 - 370 2021.2

Research on FLT3 mutations and targeted therapeutics Invited International journal

Naoe Tomoki, Kiyoi Hitoshi, Yokota Shohei

CANCER SCIENCE Vol. 112 page： 1016 - 1016 2021.2

A case of reexpansion pulmonary edema and acute pulmonary thromboembolism associated with diffuse large B-cell lymphoma treated with venovenous extracorporeal membrane oxygenation. Reviewed International journal

Kazama S, Hiraiwa H, Kimura Y, Ozaki R, Shibata N, Arao Y, Oishi H, Kato H, Kuwayama T, Yamaguchi S, Kondo T, Furusawa K, Morimoto R, Okumura T, Bando YK, Sato T, Shimada K, Kiyoi H, Nakamura G, Yasuda Y, Kasugai D, Ogawa H, Higashi M, Yamamoto T, Jingushi N, Ozaki M, Numaguchi A, Goto Y, Matsuda N, Murohara T

Journal of cardiology cases Vol. 23 ( 1 ) page： 53 - 56 2021.1

Bursitis, Bacteremia, and Disseminated Infection of Mycobacteroides (Mycobacterium) abscessus subsp. massiliense Reviewed International journal Open Access

Oka Keisuke, Morioka Hiroshi, Eguchi Motoki, Sato Yoshitaka, Tetsuka Nobuyuki, Iguchi Mitsutaka, Kanematsu Takeshi, Fukano Hanako, Hoshino Yoshihiko, Kiyoi Hitoshi, Yagi Tetsuya

INTERNAL MEDICINE Vol. 60 ( 18 ) page： 3041 - 3045 2021

Predictors of early death, serious hemorrhage, and differentiation syndrome in Japanese patients with acute promyelocytic leukemia Reviewed International journal

Minamiguchi Hitoshi, Fujita Hiroyuki, Atsuta Yoshiko, Asou Norio, Sakura Toru, Ueda Yasunori, Sawa Masashi, Dobashi Nobuaki, Taniguchi Yasuhiro, Suzuki Rikio, Uchino Yoshihito, Tomita Akihiro, Tamaki Shigehisa, Hagihara Maki, Fujimaki Katsumichi, Yanada Masamitsu, Maeda Yoshinobu, Iwanaga Masako, Usui Noriko, Kobayashi Yukio, Ohtake Shigeki, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Naoe Tomoki, Takeshita Akihiro

ANNALS OF HEMATOLOGY Vol. 99 ( 12 ) page： 2787 - 2800 2020.12

Multi-Lineage BCR-ABL Expression in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Is Associated With Improved Prognosis but No Specific Molecular Features Reviewed International journal Open Access

Nishiwaki Satoshi, Kim Jeong Hui, Ito Masafumi, Maeda Matsuyoshi, Okuno Yusuke, Koyama Daisuke, Ozawa Yukiyasu, Gunji Masaharu, Osaki Masahide, Kitamura Kunio, Ushijima Yoko, Ishikawa Yuichi, Miyamura Koichi, Sugiura Isamu, Kiyoi Hitoshi

FRONTIERS IN ONCOLOGY Vol. 10 page： 586567 2020.10

Phase I study of duvelisib in Japanese patients with relapsed or refractory lymphoma Reviewed International journal

Izutsu Koji, Kato Koji, Kiyoi Hitoshi, Yamamoto Go, Shimada Kazuyuki, Akashi Koichi

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 112 ( 4 ) page： 504 - 509 2020.10

Artificial T Cell Adaptor Molecule-Transduced TCR-T Cells Demonstrated Improved Proliferation Only When Transduced in a Higher Intensity Reviewed International journal Open Access

Sakai Toshiyasu, Terakura Seitaro, Miyao Kotaro, Okuno Shingo, Adachi Yoshitaka, Umemura Koji, Julamanee Jakrawadee, Watanabe Keisuke, Hamana Hiroshi, Kishi Hiroyuki, Leitner Judith, Steinberger Peter, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

MOLECULAR THERAPY-ONCOLYTICS Vol. 18 page： 613 - 622 2020.9

Real-world management of infection during chemotherapy for acute leukemia in Japan: from the results of a nationwide questionnaire-based survey by the Japan Adult Leukemia Study Group Reviewed International journal

Kimura Shun-ichi, Fujita Hanako, Handa Hiroshi, Hiramoto Nobuhiro, Hosono Naoko, Minamiguchi Hitoshi, Takahashi Tsutomu, Kato Hideaki, Ono Takaaki, Kanda Yoshinobu, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 112 ( 3 ) page： 409 - 417 2020.9

Clinical utility of target capture-based panel sequencing in hematological malignancies: A multicenter feasibility study Reviewed International journal Open Access

Yasuda Takahiko, Sanada Masashi, Nishijima Dai, Kanamori Takashi, Iijima Yuka, Hattori Hiroyoshi, Saito Akiko, Miyoshi Hiroaki, Ishikawa Yuichi, Asou Norio, Usuki Kensuke, Hirabayashi Shinsuke, Kato Motohiro, Ri Masaki, Handa Hiroshi, Ishida Tadao, Shibayama Hirohiko, Abe Masahiro, Iriyama Chisako, Karube Kennosuke, Nishikori Momoko, Ohshima Koichi, Kataoka Keisuke, Yoshida Kenichi, Shiraishi Yuichi, Goto Hiroaki, Adachi Souichi, Kobayashi Ryoji, Kiyoi Hitoshi, Miyazaki Yasushi, Ogawa Seishi, Kurahashi Hiroki, Yokoyama Hisayuki, Manabe Atsushi, Iida Shinsuke, Tomita Akihiro, Horibe Keizo

CANCER SCIENCE Vol. 111 ( 9 ) page： 3367 - 3378 2020.9

Phase 1b/2 study of blinatumomab in Japanese adults with relapsed/refractory acute lymphoblastic leukemia (vol 111, pg 1314, 2020) Reviewed International coauthorship International journal Open Access

Kiyoi Hitoshi, Morris Joan D., Oh Iekuni, Maeda Yoshinobu, Minami Hironobu, Miyamoto Toshihiro, Sakura Toru, Iida Hiroatsu, Tuglus Catherine A., Chen Yuqi, Dos Santos Cedric, Kalabus James, Anderson Abraham, Hata Tomoko, Nakashima Yasuhiro, Kobayashi Yukio

CANCER SCIENCE Vol. 111 ( 8 ) page： 3082 - 3082 2020.8

Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells. Reviewed International journal Open Access

Tange N, Hayakawa F, Yasuda T, Odaira K, Yamamoto H, Hirano D, Sakai T, Terakura S, Tsuzuki S, Kiyoi H

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Vol. 128 page： 110330 2020.8

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia. Reviewed International journal

Tsuzuki S, Yasuda T, Kojima S, Kawazu M, Akahane K, Inukai T, Imaizumi M, Morishita T, Miyamura K, Ueno T, Karnan S, Ota A, Hyodo T, Konishi H, Sanada M, Nagai H, Horibe K, Tomita A, Suzuki K, Muramatsu H, Takahashi Y, Miyazaki Y, Matsumura I, Kiyoi H, Hosokawa Y, Mano H, Hayakawa F

Blood cancer discovery Vol. 1 ( 1 ) page： 82 - 95 2020.7

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia Reviewed International journal Open Access

Tsuzuki Shinobu, Yasuda Takahiko, Kojima Shinya, Kawazu Masahito, Akahane Koshi, Inukai Takeshi, Imaizumi Masue, Morishita Takanobu, Miyamura Koichi, Ueno Toshihide, Karnan Sivasundaram, Ota Akinobu, Hyodo Toshinori, Konishi Hiroyuki, Sanada Masashi, Nagai Hirokazu, Horibe Keizo, Tomita Akihiro, Suzuki Kyogo, Muramatsu Hideki, Takahashi Yoshiyuki, Miyazaki Yasushi, Matsumura Itaru, Kiyoi Hitoshi, Hosokawa Yoshitaka, Mano Hiroyuki, Hayakawa Fumihiko

BLOOD CANCER DISCOVERY Vol. 1 ( 1 ) page： 82 - 95 2020.7

Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies Reviewed International journal

Mizuno Kazuyuki, Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Kawashima Hiroki, Inukai Yosuke, Toyoda Hidenori, Yokota Kenji, Hase Tetsunari, Maeda Osamu, Kiyoi Hitoshi, Nagino Masato, Hibi Hideharu, Kodera Yasuhiro, Fujimoto Yasushi, Sone Michihiko, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Fujishiro Mitsuhiro

JOURNAL OF GASTROENTEROLOGY Vol. 55 ( 6 ) page： 653 - 661 2020.6

Impact of CD56 Continuously Recognizable as Prognostic Value of Acute Promyelocytic Leukemia: Results of Multivariate Analyses in the Japan Adult Leukemia Study Group (JALSG)-APL204 Study and a Review of the Literature. Reviewed International journal Open Access

Takeshita A, Asou N, Atsuta Y, Furumaki H, Sakura T, Ueda Y, Sawa M, Dobashi N, Taniguchi Y, Suzuki R, Nakagawa M, Tamaki S, Hagihara M, Fujimaki K, Minamiguchi H, Fujita H, Yanada M, Maeda Y, Usui N, Kobayashi Y, Kiyoi H, Ohtake S, Matsumura I, Naoe T, Miyazaki Y, Group TJALS

Cancers Vol. 12 ( 6 ) 2020.6

JSH Practical Guidelines for Hematological Malignancies, 2018: I. Leukemia-1. Acute myeloid leukemia (AML) Invited Reviewed International journal

Kiyoi Hitoshi, Yamaguchi Hiroki, Maeda Yoshinobu, Yamauchi Takahiro

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 111 ( 5 ) page： 595 - 613 2020.5

Higher FVIII:C measured by chromogenic substrate assay than by one-stage assay is associated with silent hemophilic arthropathy Reviewed International journal Open Access

Ogawa Mika, Suzuki Nobuaki, Takahashi Nobunori, Tamura Shogo, Suzuki Atsuo, Suzuki Sachiko, Hattori Yuua, Kakihara Misaki, Kanematsu Takeshi, Kojima Toshihisa, Katsumi Akira, Hayakawa Fumihiko, Kojima Tetsuhito, Ishiguro Naoki, Kiyoi Hitoshi, Matsushita Tadashi

THROMBOSIS RESEARCH Vol. 188 page： 103 - 105 2020.4

Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): a multicentre, single-arm, phase 2 trial Reviewed International journal

Shimada Kazuyuki, Yamaguchi Motoko, Atsuta Yoshiko, Matsue Kosei, Sato Keijiro, Kusumoto Shigeru, Nagai Hirokazu, Takizawa Jun, Fukuhara Noriko, Nagafuji Koji, Miyazaki Kana, Ohtsuka Eiichi, Okamoto Masataka, Sugita Yasumasa, Uchida Toshiki, Kayukawa Satoshi, Wake Atsushi, Ennishi Daisuke, Kondo Yukio, Izumi Tohru, Kin Yoshihiro, Tsukasaki Kunihiro, Hashimoto Daigo, Yuge Masaaki, Yanagisawa Atsumi, Kuwatsuka Yachiyo, Shimada Satoko, Masaki Yasufumi, Niitsu Nozomi, Kiyoi Hitoshi, Suzuki Ritsuro, Tokunaga Takashi, Nakamura Shigeo, Kinoshita Tomohiro

LANCET ONCOLOGY Vol. 21 ( 4 ) page： 593 - 602 2020.4

Phase 1b/2 study of blinatumomab in Japanese adults with relapsed/refractory acute lymphoblastic leukemia Reviewed International coauthorship International journal Open Access

Kiyoi Hitoshi, Morris Joan D., Oh Lekuni, Maeda Yoshinobu, Minami Hironobu, Miyamoto Toshihiro, Sakura Toru, Iida Hiroatsu, Tuglus Catherine A., Chen Yuqi, Dos Santos Cedric, Kalabus James, Anderson Abraham, Hata Tomoko, Nakashima Yasuhiro, Kobayashi Yukio

CANCER SCIENCE Vol. 111 ( 4 ) page： 1314 - 1323 2020.4

Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study. Reviewed International journal Open Access

Okada N, Iwama S, Okuji T, Kobayashi T, Yasuda Y, Wada E, Onoue T, Goto M, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Hase T, Morise M, Kanda M, Yokota K, Hashimoto N, Ando M, Fujimoto Y, Nagino M, Kodera Y, Fujishiro M, Hibi H, Sone M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H

British journal of cancer Vol. 122 ( 6 ) page： 771 - 777 2020.3

悪性リンパ腫診療の進歩とピットフォール Invited Open Access

島田和之、清井仁

日本内科学会雑誌 Vol. 109 ( 3 ) page： 574 - 578 2020.3

FLT3 mutations in acute myeloid leukemia: Therapeutic paradigm beyond inhibitor development Invited Reviewed International journal Open Access

Kiyoi, H; Kawashima, N; Ishikawa, Y

CANCER SCIENCE Vol. 111 ( 2 ) page： 312 - 322 2020.2

Prospective evaluation of prognostic impact of KIT mutations on acute myeloid leukemia with RUNX1-RUNX1T1 and CBFB-MYH11 Reviewed International journal Open Access

Ishikawa Yuichi, Kawashima Naomi, Atsuta Yoshiko, Sugiura Isamu, Sawa Masashi, Dobashi Nobuaki, Yokoyama Hisayuki, Doki Noriko, Tomita Akihiro, Kiguchi Toru, Koh Shiro, Kanamori Heiwa, Iriyama Noriyoshi, Kohno Akio, Moriuchi Yukiyoshi, Asada Noboru, Hirano Daiki, Togitani Kazuto, Sakura Toru, Hagihara Maki, Tomikawa Tatsuki, Yokoyama Yasuhisa, Asou Norio, Ohtake Shigeki, Matsumura Itaru, Miyazaki Yasushi, Naoe Tomoki, Kiyoi Hitoshi

BLOOD ADVANCES Vol. 4 ( 1 ) page： 66 - 75 2020.1

Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation. Reviewed International journal Open Access

Kamoshita S, Murata M, Koyama D, Julamanee J, Okuno S, Takagi E, Miyao K, Goto T, Ozawa Y, Miyamura K, Terakura S, Nishida T, Kiyoi H

International journal of hematology Vol. 111 ( 1 ) page： 112 - 119 2020.1

Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia Reviewed International journal Open Access

Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko

INTERNAL MEDICINE Vol. 59 ( 5 ) page： 683 - 687 2020

Allogeneic Hematopoietic Stem Cell Transplantation for Post-essential Thrombocythemia and Post-polycythemia Vera Myelofibrosis Reviewed International journal Open Access

Murata, M; Suzuki, R; Nishida, T; Shirane, S; Shimazu, Y; Minami, Y; Mori, T; Doki, N; Kanda, Y; Uchida, N; Tanaka, M; Ishikawa, J; Togitani, K; Fukuda, T; Ichinohe, T; Atsuta, Y; Nagamura-Inoue, T; Kiyoi, H

INTERNAL MEDICINE Vol. 59 ( 16 ) page： 1947 - 1956 2020

Successful Perioperative Combination of High-Dose FVIII Therapy Followed by Emicizumab in a Patient with Hemophilia A with Inhibitors.

Okamoto S, Suzuki N, Suzuki A, Suzuki S, Tamura S, Suzuki M, Takahashi N, Kojima T, Kanematsu T, Kojima T, Kiyoi H, Ishiguro N, Matsushita T

TH open : companion journal to thrombosis and haemostasis Vol. 3 ( 4 ) page： e364-e366 2019.10

ZNF384-fusion proteins have high affinity for the transcriptional coactivator EP300 and aberrant transcriptional activities. Reviewed International journal Open Access

Yamamoto H, Hayakawa F, Yasuda T, Odaira K, Minamikawa Y, Tange N, Hirano D, Kojima Y, Morishita T, Tsuzuki S, Naoe T, Kiyoi H

FEBS letters Vol. 593 ( 16 ) page： 2151 - 2161 2019.8

Exome analysis of treatment-related AML after APL suggests secondary evolution. Reviewed International coauthorship International journal Open Access

Wang T, Jacoby MA, Duncavage EJ, Miller CA, Heath S, Rahme R, Fenaux P, Ades L, Renneville A, Cassinat B, Takeshita A, Asou N, Miyazaki Y, Kiyoi H, Ravandi F, Westervelt P, Wartman LD, Welch JS

British journal of haematology Vol. 185 ( 5 ) page： 984 - 987 2019.6

Efficacy and safety of tyrosine kinase inhibitors for newly diagnosed chronic-phase chronic myeloid leukemia over a 5-year period: results from the Japanese registry obtained by the New TARGET system Invited Reviewed International journal

Kizaki Masahiro, Takahashi Naoto, Iriyama Noriyoshi, Okamoto Shinichiro, Ono Takaaki, Usui Noriko, Inokuchi Koiti, Nakaseko Chiaki, Kurokawa Mineo, Sumi Masahiko, Nakamura Fumihiko, Kawaguchi Tatsuya, Suzuki Ritsuro, Yamamoto Kazuhito, Ohnishi Kazunori, Matsumura Itaru, Naoe Tomoki, Kizaki M., Mori S., Nemoto T., Sagawa M., Tabayashi T., Tokuhira M., Tomikawa T., Watanabe R., Hatta Y., Inoue Y., Iriyama N., Kobayashi S., Kobayashi Y., Kurita D., Karigane D., Kasahara H., Koda Y., Miyakawa Y., Murakami K., Okamoto S., Watanuki S., Ono T., Nagata Y., Takeshita A., Takahashi N., Kameoka Y., Yoshioka T., Takahashi S., Usui N., Dan K., Inokuchi K., Nakamura K., Abe D., Nakaseko C., Ohwada C., Sakaida E., Shimizu N., Takeuchi M., Arai S., Kogure Y., Koya A., Masamoto Y., Masuda A., Nakazaki K., Toyama K., Hiroshima Y., Ichikawa N., Kirihara T., Kobayashi H., Shimizu I., Sumi M., Ueki T., Hagiwara S., Hirai R., Miwa T., Nakamura F., Nakamura M., Takeshita M., Tanimura A., Hayakawa F., Ishikawa Y., Kiyoi H., Murata M., Tomita A., Kurokawa T., Sugimori C., Arai A., Miura O., Yamamoto M., Imai K., Kobayashi N., Minauchi K., Obara M., Ota S., Ikezoe T., Mori M., Sakai M., Taniguchi A., Togitani K., Hayakawa H., Kajiguchi T., Kamoshita S., Otsuka E., Nishida A., Saburi M., Saburi Y., Iida H., Kato C., Kojima Y., Ohashi H., Miyata Y., Sugimoto K., Yamamoto H., Yokozawa T., Kamae T., Kuyama J., Mitsui H., Morikawa Y., Uchida Y., Ashida T., Hirase C., Kawanishi K., Matsumura I., Miyatake J., Morita Y., Sano T., Shimada T., Tanaka H., Taniguchi Y., Tatsumi Y., Yamaguchi K., Ishida F., Momose K., Nakazawa H., Nishina S., Sakai H., Sekiguchi N., Ito Y., Ohyashiki K., Tauchi T., Hata T., Imaizumi Y., Imanishi D., Itonaga H., Makiyama J., Sawayama Y., Taguchi J., Taguchi M., Taniguchi H., Eguchi G., Matsuda M., Yamairi N., Fukushima N., Ozeki K., Kohno A., Sakura T., Takada S., Kobayashi T., Sakamaki H., Asou N., Kawaguchi T., Kiguchi T., Masunari T., Sezaki N., Iino M., Morinaga K., Ikeda K., Ogawa K., Noji H., Iwasaki H., Takenaka K., Miyamoto T., Handa H., Murakami H., Tsukamoto N., Eto T., Henzan H., Kamitsuji Y., Uoshima N., Hagihara M., Takahashi H., Emi N., Okamoto M., Kawakami K., Waki M., Fukuhara N., Harigae H., Murayama T., Mizuno I., Okumura H., Tsutsumi Y., Usuki K., Fujisaki T., Maeda Y., Suehiro Y., Suzushima H., Yamamoto K., Kanakura Y., Nagasaki K., Muto H., Fujisawa S., Mugitani A., Yamasaki S., Adachi Y., Kamimura T., Takamatsu Y., Ryu T., Chiba S., Ohishi K., Suzuki K., Ogawa D., Mihara H., Fujita H., Kubo K., Yokota A., Yoshida C., Nakachi S., Myojyo T., Kitabayashi A., Suzumiya J., Hino M., Wakita A., Shibata T., Takahashi T., Takamatsu H., Fujimaki K., Tajika K., Mita M., Terui Y., Ito M., Yamane T., Yamamoto K., Yamauchi T., Kohara Y., Takebayashi C., Inagaki A., Tsuji M., Shinzaki H., Moriuchi Y., Ishikawa M., Miyazaki K., Shima E., Kinugawa N.

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 109 ( 4 ) page： 426 - 439 2019.4

Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity. Reviewed International journal

Hirano D, Hayakawa F, Yasuda T, Tange N, Yamamoto H, Kojima Y, Morishita T, Imoto N, Tsuzuki S, Mano H, Naoe T, Kiyoi H

Oncogene Vol. 38 ( 13 ) page： 2263 - 2274 2019.3

Defective Epstein-Barr virus in chronic active infection and haematological malignancy. Reviewed International journal

Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H

Nat Microbiol. Vol. 4 ( 3 ) page： 404 - 413 2019.3

Quantitative Assessment of T Cell Clonotypes in Human Acute Graft-versus-Host Disease Tissues. Reviewed International journal Open Access

Koyama D, Murata M, Hanajiri R, Akashi T, Okuno S, Kamoshita S, Julamanee J, Takagi E, Miyao K, Sakemura R, Goto T, Terakura S, Nishida T, Kiyoi H

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Vol. 25 ( 3 ) page： 417 - 423 2019.3

Publisher Correction: Defective Epstein-Barr virus in chronic active infection and haematological malignancy. Reviewed International journal Open Access

Nature microbiology Vol. 4 ( 3 ) page： 544 2019.3

Tamibarotene maintenance improved relapse-free survival of acute promyelocytic leukemia: a final result of prospective, randomized, JALSG-APL204 study. Reviewed International journal

Takeshita A, Asou N, Atsuta Y, Sakura T, Ueda Y, Sawa M, Dobashi N, Taniguchi Y, Suzuki R, Nakagawa M, Tamaki S, Hagihara M, Fujimaki K, Furumaki H, Obata Y, Fujita H, Yanada M, Maeda Y, Usui N, Kobayashi Y, Kiyoi H, Ohtake S, Matsumura I, Naoe T, Miyazaki Y, and the Japanese Adult Leukemia Study Group.

Leukemia Vol. 33 ( 2 ) page： 358 - 370 2019.2

Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study. Reviewed International journal Open Access

Kawashima N, Akashi A, Nagata Y, Kihara R, Ishikawa Y, Asou N, Ohtake S, Miyawaki S, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kitamura K, Sakaida E, Takeshita A, Suzushima H, Naoe T, Matsumura I, Miyazaki Y, Ogawa S, Kiyoi H, Japan Adult Leukemia Study Group (JALSG).

Annals of hematology Vol. 98 ( 1 ) page： 83 - 91 2019.1

[Acute myeloid leukemia: AML]. Invited

Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology Vol. 60 ( 3 ) page： 224 - 225 2019

[Successful treatment of pre-engraftment disseminated fusariosis with high-dose liposomal amphotericin B in a cord blood transplant recipient]. Reviewed

Harada Y, Murata M, Matsumoto A, Kato D, Yagi T, Yaguchi T, Yoshikawa T, Takeichi T, Akiyama M, Yamaguchi Y, Koyama D, Terakura S, Nishida T, Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology Vol. 60 ( 12 ) page： 1641 - 1646 2019

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. Reviewed Open Access

Proceedings of the National Academy of Sciences of the United States of America 2018.11

Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells. Reviewed Open Access

Sakamoto A, Kunou S, Shimada K, Tsunoda M, Aoki T, Iriyama C, Tomita A, Nakamura S, Hayakawa F, Kiyoi H

Cancer science 2018.11

Final analysis of the JALSG Ph+ALL202 study: tyrosine kinase inhibitor-combined chemotherapy for Ph plus ALL Reviewed International journal Open Access

Hatta Yoshihiro, Mizuta Shuichi, Matsuo Keitaro, Ohtake Shigeki, Iwanaga Masako, Sugiura Isamu, Doki Noriko, Kanamori Heiwa, Ueda Yasunori, Yoshida Chikamasa, Dobashi Nobuaki, Maeda Tomoya, Yujiri Toshiaki, Monma Fumihiko, Ito Yoshikazu, Hayakawa Fumihiko, Takeuchi Jin, Kiyoi Hitoshi, Miyazaki Yasushi, Naoe Tomoki

ANNALS OF HEMATOLOGY Vol. 97 ( 9 ) page： 1535 - 1545 2018.9

Prognostic Analysis According to the 2017 ELN Risk Stratification by Genetics in Adult Acute Myeloid Leukemia Patients Treated in The Japan Adult Leukemia Study Group (JALSG) AML201 study Reviewed

Harada Yasuhiko, Nagata Yasunobu, Kihara Rika, Ishikawa Yuichi, Asou Norio, Ohtake Shigeki, Miyawaki Shuichi, Sakura Toru, Ozawa Yukiyasu, Usui Noriko, Kanamori Heiwa, Ito Yoshikazu, Imai Kiyotoshi, Suehiro Youko, Kobayashi Shinichi, Kitamura Kunio, Sakaida Emiko, Onizuka Makoto, Takeshita Akihiro, Ishida Fumihiro, Suzushima Hitoshi, Ishizawa Kenichi, Naoe Tomoki, Matsumura Itaru, Miyazaki Yasushi, Ogawa Seishi, Kiyoi Hitoshi

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA Vol. 18 page： S196-S196 2018.9

Impact of hospital length of stay on the risk of readmission and overall survival after allogeneic stem cell transplantation Reviewed International journal Open Access

Seto Aika, Atsuta Yoshiko, Kawashima Naomi, Ozawa Yukiyasu, Miyamura Koichi, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 108 ( 3 ) page： 290 - 297 2018.9

Biology and management of primary effusion lymphoma. Reviewed Open Access

Shimada K, Hayakawa F, Kiyoi H

Blood 2018.8

Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response Reviewed International journal Open Access

Ueda Norihiro, Uemura Yasushi, Zhang Rong, Kitayama Shuichi, Iriguchi Shoichi, Kawai Yohei, Yasui Yutaka, Tatsumi Minako, Ueda Tatsuki, Liu Tian-Yi, Mizoro Yasutaka, Okada Chihiro, Watanabe Akira, Nakanishi Mahito, Senju Satoru, Nishimura Yasuharu, Kuzushima Kiyotaka, Kiyoi Hitoshi, Naoe Tomoki, Kaneko Shin

STEM CELL REPORTS Vol. 10 ( 6 ) page： 1935 - 1946 2018.6

Infectious complications in adults undergoing intensive chemotherapy for acute myeloid leukemia in 2001-2005 using the Japan Adult Leukemia Study Group AML201 protocols.

Kato H, Fujita H, Akiyama N, Kimura SI, Hiramoto N, Hosono N, Takahashi T, Shigeno K, Minamiguchi H, Miyatake J, Handa H, Kanda Y, Yoshida M, Miyawaki S, Ohtake S, Naoe T, Kiyoi H, Matsumura I, Miyazaki Y, Japan Adult Leukemia Study Group.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2018.6

Introduction of Genetically Modified CD3 zeta Improves Proliferation and Persistence of Antigen-Specific CTLs Reviewed International journal Open Access

Miyao Kotaro, Terakura Seitaro, Okuno Shingo, Julamanee Jakrawadee, Watanabe Keisuke, Hamana Hiroshi, Kishi Hiroyuki, Sakemura Reona, Koyama Daisuke, Goto Tatsunori, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

CANCER IMMUNOLOGY RESEARCH Vol. 6 ( 6 ) page： 733 - 744 2018.6

Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia. Reviewed Open Access

Tanaka Y, Kawazu M, Yasuda T, Tamura M, Hayakawa F, Kojima S, Ueno T, Kiyoi H, Naoe T, Mano H

Haematologica 2018.5

Mutation analysis of therapy-related myeloid neoplasms Reviewed International journal

Nishiyama Takahiro, Ishikawa Yuichi, Kawashima Naomi, Akashi Akimi, Adachi Yoshiya, Hattori Hikaru, Ushijima Yoko, Kiyoi Hitoshi

CANCER GENETICS Vol. 222 page： 38 - 45 2018.4

Phase I study of cord blood transplantation with intrabone marrow injection of mesenchymal stem cells: A clinical study protocol Reviewed International journal Open Access

Goto Tatsunori, Murata Makoto, Terakura Seitaro, Nishida Tetsuya, Adachi Yoshiya, Ushijima Yoko, Shimada Kazuyuki, Ishikawa Yuichi, Hayakawa Fumihiko, Nishio Nobuhiro, Nishiwaki Satoshi, Hirakawa Akihiro, Kato Katsuyoshi, Takahashi Yoshiyuki, Kiyoi Hitoshi

MEDICINE Vol. 97 ( 17 ) page： e0449 2018.4

Analysis of the oligomeric states of nucleophosmin using size exclusion chromatography Reviewed International journal Open Access

Sakashita Gyosuke, Kiyoi Hitoshi, Naoe Tomoki, Urano Takeshi

SCIENTIFIC REPORTS Vol. 8 ( 1 ) page： 4008 2018.3

Clinical impact of underweight status at diagnosis on elderly patients with acute myeloid leukemia: a retrospective study of JALSG GML200. Reviewed

Harada K, Doki N, Miyazaki Y, Wakita A, Ohtake S, Takada S, Komatsu H, Kubo K, Takeshita A, Adachi Y, Kiyoi H, Yamaguchi T, Yoshida M, Naoe T, Ohashi K

Annals of hematology 2018.3

High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG. Reviewed International journal

Sakura T, Hayakawa F, Sugiura I, Murayama T, Imai K, Usui N, Fujisawa S, Yamauchi T, Yujiri T, Kakihana K, Ito Y, Kanamori H, Ueda Y, Miyata Y, Kurokawa M, Asou N, Ohnishi K, Ohtake S, Kobayashi Y, Matsuo K, Kiyoi H, Miyazaki Y, Naoe T.

Leukemia Vol. 32 ( 3 ) page： 626 - 632 2018.3

Prognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 study. Reviewed Open Access

Harada Y, Nagata Y, Kihara R, Ishikawa Y, Asou N, Ohtake S, Miyawaki S, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kobayashi S, Kitamura K, Sakaida E, Onizuka M, Takeshita A, Ishida F, Suzushima H, Ishizawa K, Naoe T, Matsumura I, Miyazaki Y, Ogawa S, Kiyoi H, Japan Adult Leukemia Study Group JALSG.

Leukemia research Vol. 66 page： 20-27 2018.3

High Incidence of Extensive Chronic Gvhd in Patients with the REG3A Rs7588571 Non-GG Genotype Reviewed Open Access

Murata Makoto, Koyama Daisuke, Hanajiri Ryo, Okuno Shingo, Kamoshita Sonoko, Julamanee Jakrawadee, Takagi Erina, Hirano Daiki, Miyao Kotaro, Sakemura Reona, Goto Tatsunori, Hayakawa Fumihiko, Seto Aika, Ozawa Yukiyasu, Miyamura Koichi, Terakura Seitaro, Nishida Tetsuya, Kiyoi Hitoshi

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Vol. 24 ( 3 ) page： S192-S193 2018.3

Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study Reviewed International journal

Kobayashi Tomoko, Iwama Shintaro, Yasuda Yoshinori, Okada Norio, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Morishita Yoshiaki, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Yokota Kenji, Hase Tetsunari, Morise Masahiro, Hashimoto Naozumi, Ando Masahiko, Kiyoi Hitoshi, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

JOURNAL OF THE ENDOCRINE SOCIETY Vol. 2 ( 3 ) page： 241 - 251 2018.3

Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in de novo acute myeloid leukemia. Reviewed Open Access

Kamijo R, Itonaga H, Kihara R, Nagata Y, Hata T, Asou N, Ohtake S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Naoe T, Kiyoi H, Miyazaki Y

Leukemia research Vol. 65 page： 34-41 2018.2

Intrabone single unit cord blood transplantation for hematological malignancies Reviewed

Murata Makoto, Maeda Yoshinobu, Masuko Masayoshi, Fukuhara Noriko, Nishida Tetsuya, Terakura Seitaro, Ishikawa Yuichi, Tanimoto Mitsune, Shibasaki Yasuhiko, Suzuki Ritsuro, Kodera Yoshihisa, Kiyoi Hitoshi, Naoe Tomoki

CANCER SCIENCE Vol. 109 page： 757-757 2018.1

BCR-ABL-specific CD4+ T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells. Reviewed International journal Open Access

Ueda N, Zhang R, Tatsumi M, Liu TY, Kitayama S, Yasui Y, Sugai S, Iwama T, Senju S, Okada S, Nakatsura T, Kuzushima K, Kiyoi H, Naoe T, Kaneko S, Uemura Y

Cellular & molecular immunology Vol. 15 ( 1 ) page： 15 - 26 2018.1

Underweight status at diagnosis is associated with poorer outcomes in adult patients with acute myeloid leukemia: a retrospective study of JALSG AML 201 Reviewed International journal

Harada Kaito, Doki Noriko, Hagino Takeshi, Miyawaki Shuichi, Ohtake Shigeki, Kiyoi Hitoshi, Miyazaki Yasushi, Fujita Hiroyuki, Usui Noriko, Okumura Hirokazu, Miyamura Koichi, Nakaseko Chiaki, Fujieda Atsushi, Nagai Tadashi, Yamane Takahisa, Sakamaki Hisashi, Ohnishi Kazunori, Naoe Tomoki, Ohno Ryuzo, Ohashi Kazuteru

ANNALS OF HEMATOLOGY Vol. 97 ( 1 ) page： 73 - 81 2018.1

Identification of the novel deletion-type PML-RARA mutation associated with the retinoic acid resistance in acute promyelocytic leukemia. Reviewed Open Access

Hattori H, Ishikawa Y, Kawashima N, Akashi A, Yamaguchi Y, Harada Y, Hirano D, Adachi Y, Miyao K, Ushijima Y, Terakura S, Nishida T, Matsushita T, Kiyoi H

PloS one Vol. 13 ( 10 ) page： e0204850 2018

Underweight status at diagnosis is associated with poorer outcomes in adult patients with acute myeloid leukemia: a retrospective study of JALSG AML 201. Reviewed

Harada K, Doki N, Hagino T, Miyawaki S, Ohtake S, Kiyoi H, Miyazaki Y, Fujita H, Usui N, Okumura H, Miyamura K, Nakaseko C, Fujieda A, Nagai T, Yamane T, Sakamaki H, Ohnishi K, Naoe T, Ohno R, Ohashi K

Ann Hematol. 2017.12

Efficacy and safety of autologous peripheral blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia: A study protocol for a multicenter exploratory prospective study (Auto-Ph17 study) Reviewed International journal Open Access

Nishiwaki Satoshi, Sugiura Isamu, Miyata Yasuhiko, Saito Shigeki, Sawa Masashi, Nishida Tetsuya, Miyamura Koichi, Kuwatsuka Yachiyo, Kohno Akio, Yuge Masaaki, Kasai Masanobu, Iida Hiroatsu, Kurahashi Shingo, Osaki Masahide, Goto Tatsunori, Terakura Seitaro, Murata Makoto, Nishikawa Hiroyoshi, Kiyoi Hitoshi

MEDICINE Vol. 96 ( 52 ) page： e9568 2017.12

Altered EZH2 splicing and expression is associated with impaired histone H3 lysine 27 tri-Methylation in myelodysplastic syndrome. Reviewed Open Access

Shirahata-Adachi M, Iriyama C, Tomita A, Suzuki Y, Shimada K, Kiyoi H.

Leuk Res Vol. 63 page： 90-97 2017.11

Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia. Reviewed Open Access

Kuwatsuka Y, Tomizawa D, Kihara R, Nagata Y, Shiba N, Iijima-Yamashita Y, Shimada A, Deguchi T, Miyachi H, Tawa A, Taga T, Kinoshita A, Nakayama H, Kiyokawa N, Saito AM, Koh K, Goto H, Kosaka Y, Asou N, Ohtake S, Miyawaki S, Miyazaki Y, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kobayashi S, Kitamura K, Sakaida E, Ogawa S, Naoe T, Hayashi Y, Horibe K, Manabe A, Mizutani S, Adachi S, Kiyoi H.

Int J Hematol 2017.10

Identification of volasertib-resistant mechanism and evaluation of combination effects with volasertib and other agents on acute myeloid leukemia. Reviewed Open Access

Adachi Y, Ishikawa Y, Kiyoi H.

Oncotarget Vol. 8 page： 78452-78465 2017.10

A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study). Reviewed Open Access

Kobayashi T, Nannya Y, Ichikawa M, Oritani K, Kanakura Y, Tomita A, Kiyoi H, Kobune M, Kato J, Kawabata H, Shindo M, Torimoto Y, Yonemura Y, Hanaoka N, Nakakuma H, Hasegawa D, Manabe A, Fujishima N, Fujii N, Tanimoto M, Morita Y, Matsuda A, Fujieda A, Katayama N, Ohashi H, Nagai H, Terada Y, Hino M, Sato K, Obara N, Chiba S, Usuki K, Ohta M, Imataki O, Uemura M, Takaku T, Komatsu N, Kitanaka A, Shimoda K, Watanabe K, Tohyama K, Takaori-Kondo A, Harigae H, Arai S, Miyazaki Y, Ozawa K, Kurokawa M; for National Research Group on Idiopathic Bone Marrow Failure Syndromes.

Am J Hematol Vol. 92 page： 1324-1332 2017.9

High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype. Open Access

Koyama D, Murata M, Hanajiri R, Okuno S, Kamoshita S, Julamanee J, Takagi E, Hirano D, Miyao K, Sakemura R, Goto T, Hayakawa F, Seto A, Ozawa Y, Miyamura K, Terakura S, Nishida T, Kiyoi H.

PLoS One12 page： e0185213 2017.9

Deeper molecular response is a predictive factor for treatment-free remission after imatinib discontinuation in patients with chronic phase chronic myeloid leukemia: the JALSG-STIM213 study. Reviewed

Takahashi N, Tauchi T, Kitamura K, Miyamura K, Saburi Y, Hatta Y, Miyata Y, Kobayashi S, Usuki K, Matsumura I, Minami Y, Usui N, Fukuda T, Takada S, Ishikawa M, Fujimaki K, Gomyo H, Sasaki O, Ohishi K, Miyake T, Imai K, Suzushima H, Mitsui H, Togitani K, Kiguchi T, Atsuta Y, Ohtake S, Ohnishi K, Kobayashi Y, Kiyoi H, Miyazaki Y, Naoe T; Japan Adult Leukemia Study Group.

Int J Hematol 2017.9

Clinical effectiveness of geriatric assessment for predicting the tolerability of outpatient chemotherapy in older adults with cancer. Reviewed

Hayashi N, Matsuoka A, Goto H, Gotoh M, Kiyoi H, Kodera Y, Nagino M, Nagashima F, Ando Y.

J Geriatr Oncol 2017.8

Phase II study of intrabone single unit cord blood transplantation for hematological malignancies. Reviewed Open Access

Murata M, Maeda Y, Masuko M, Onishi Y, Endo T, Terakura S, Ishikawa Y, Iriyama C, Ushijima Y, Goto T, Fujii N, Tanimoto M, Kobayashi H, Shibasaki Y, Fukuhara N, Inamoto Y, Suzuki R, Kodera Y, Matsushita T, Kiyoi H, Naoe T, Nishida T.

Cancer Sci Vol. 108 page： 1634-1639 2017.6

MOLECULAR MARKERS PREDICTING RESPONSE TO AZACITIDINE TREATMENT FOR MYELODYSPLASTIC SYNDROMES

Nannya Y., Takeda J., Shiozawa Y., Shiraishi Y., Okuno Y., Kataoka K., Chiba K., Tanaka H., Sanada M., Chiba S., Asou N., Kiyoi H., Imai K., Hirase C., Dobashi N., Kiguchi T., Nakao S., Ohyashiki K., Miyazaki Y., Naoe T., Makishima H., Miyano S., Yoshida K., Ogawa S.

HAEMATOLOGICA Vol. 102 page： 98-99 2017.6

Management of infection during chemotherapy for acute leukemia in Japan: a nationwide questionnaire-based survey by the Japan Adult Leukemia Study Group. Reviewed

Kimura SI, Fujita H, Kato H, Hiramoto N, Hosono N, Takahashi T, Shigeno K, Hatsumi N, Minamiguchi H, Miyatake J, Handa H, Akiyama N, Kanda Y, Yoshida M, Kiyoi H, Miyazaki Y, Naoe T; Japan Adult Leukemia Study Group (JALSG).

Support Care Cancer Vol. 25 page： 3515-3521 2017.6

[I.Genetic Abnormalities Associated with Acute Leukemia and a Development of Molecular Therapies].

Adachi Y, Kiyoi H

Gan to kagaku ryoho. Cancer & chemotherapy Vol. 44 ( 5 ) page： 380-385 2017.5

YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma. Reviewed

Kojima Y, Hayakawa F, Morishita T, Sugimoto K, Minamikawa Y, Iwase M, Yamamoto H, Hirano D, Imoto N, Shimada K, Okada S, Kiyoi H.

Pharmacol Res Vol. 120 page： 242-251 2017.4

Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia. Reviewed International journal Open Access

Togasaki E, Takeda J, Yoshida K, Shiozawa Y, Takeuchi M, Oshima M, Saraya A, Iwama A, Yokote K, Sakaida E, Hirase C, Takeshita A, Imai K, Okumura H, Morishita Y, Usui N, Takahashi N, Fujisawa S, Shiraishi Y, Chiba K, Tanaka H, Kiyoi H, Ohnishi K, Ohtake S, Asou N, Kobayashi Y, Miyazaki Y, Miyano S, Ogawa S, Matsumura I, Nakaseko C, Naoe T.

Blood Cancer J Vol. 7 ( 4 ) page： e559 2017.4

Impact of T-cell chimerism on relapse after cord blood transplantation for hematological malignancies: Nagoya Blood and Marrow Transplantation Group study. Reviewed International journal Open Access

Yokohata E, Kuwatsuka Y, Ohashi H, Terakura S, Kawashima N, Seto A, Kurahashi S, Ozawa Y, Goto T, Imahashi N, Nishida T, Miyao K, Sakemura R, Kato T, Sawa M, Kohno A, Sao H, Iida H, Kiyoi H, Naoe T, Miyamura K, Murata M.

Bone Marrow Transplant Vol. 52 ( 4 ) page： 612 - 614 2017.4

Retrospective analysis of in vivo recovery and clearance during continuous infusion of recombinant factor VIII products: a single-institution study

Suzuki N., Hirakawa A., Kishimoto M., Kanematsu T., Ogawa M., Kiyoi H., Matsushita T.

HAEMOPHILIA Vol. 23 ( 2 ) page： 215-221 2017.3

Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism. Open Access

Aoki T, Shimada K, Sakamoto A, Sugimoto K, Morishita T, Kojima Y, Shimada S, Kato S, Iriyama C, Kuno S, Harada Y, Tomita A, Hayakawa F, Kiyoi H.

Oncotarget Vol. 8 page： 13085-13098 2017.2

Malignant lymphoma with cardiac involvement. Reviewed

Terakura S, Onji M, Iriyama C, Goto T, Ushijima Y, Shimada K, Ishikawa Y, Nishida T, Hayakawa F, Murata M, Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology Vol. 58 ( 3 ) page： 239 - 242 2017

A Tet-On Inducible System for Controlling CD19-Chimeric Antigen Receptor Expression upon Drug Administration. Reviewed Open Access

Sakemura R, Terakura S, Watanabe K, Julamanee J, Takagi E, Miyao K, Koyama D, Goto T, Hanajiri R, Nishida T, Murata M, Kiyoi H.

Cancer Immunol Res. Vol. 4 ( 8 ) page： 658-68 2016.8

SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. Reviewed

Takagi Y, Shimada K, Shimada S, Sakamoto A, Naoe T, Nakamura S, Hayakawa F, Tomita A, Kiyoi H.

Cancer Sci. page： [Epub ahead of print] 2016.6

PAX5 tyrosine phosphorylation by SYK co-operatively functions with its serine phosphorylation to cancel the PAX5-dependent repression of BLIMP1: A mechanism for antigen-triggered plasma cell differentiation. Reviewed

Inagaki Y, Hayakawa F, Hirano D, Kojima Y, Morishita T, Yasuda T, Naoe T, Kiyoi H.

Biochem Biophys Res Commun. Vol. 475 ( 2 ) page： 176-81 2016.6

Peripheral blood cell-free DNA is an alternative tumor DNA source reflecting disease status in myelodysplastic syndromes. Reviewed Open Access

Suzuki Y, Tomita A, Nakamura F, Iriyama C, Shirahata-Adachi M, Shimada K, Akashi A, Ishikawa Y, Kaneda N, Kiyoi H.

Cancer Sci. page： [Epub ahead of print] 2016.6

Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells. Reviewed Open Access

Chen F, Ishikawa Y, Akashi A, Naoe T, Kiyoi H.

Oncotarget. page： [Epub ahead of print] 2016.6

Live-cell single-molecule imaging of the cytokine receptor MPL for analysis of dynamic dimerization. Reviewed Open Access

Sakamoto A, Tsukamoto T, Furutani Y, Sudo Y, Shimada K, Tomita A, Kiyoi H, Kato T, Funatsu T.

J Mol Cell Biol. page： [Epub ahead of print] 2016.6

BCR-ABL-specific CD4+ T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells. Reviewed Open Access

Ueda N, Zhang R, Tatsumi M, Liu TY, Kitayama S, Yasui Y, Sugai S, Iwama T, Senju S, Okada S, Nakatsura T, Kuzushima K, Kiyoi H, Naoe T, Kaneko S, Uemura Y.

Cell Mol Immunol page： [Epub ahead of print] 2016.5

Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells. Reviewed Open Access

Maeda K, Enomoto A, Hara A, Asai N, Kobayashi T, Horinouchi A, Maruyama S, Ishikawa Y, Nishiyama T, Kiyoi H, Kato T, Ando K, Weng L, Mii S, Asai M, Mizutani Y, Watanabe O, Hirooka Y, Goto H, Takahashi M.

Sci Rep. Vol. 6 page： 22288 2016.2

B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia. Reviewed Open Access

Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, Sugimoto K, Tsuzuki S, Naoe T, Kiyoi H.

J Biol Chem. Vol. 291 ( 9 ) page： 4723-31 2016.2

The first case of antithrombin-resistant prothrombin Belgrade mutation in Japanese. Reviewed

Kishimoto M, Suzuki N, Murata M, Ogawa M, Kanematsu T, Takagi A, Kiyoi H, Kojima T, Matsushita T.

Ann Hematol. Vol. 95 ( 3 ) page： 541-2 2016.2

A case of MYH9 disorders caused by a novel mutation (p.K74E). Reviewed

Kanematsu T, Suzuki N, Yoshida T, Kishimoto M, Aoki T, Ogawa M, Kagami Y, Kiyoi H, Matsushita T, Kunishima S.

Ann Hematol Vol. 95 ( 1 ) page： 161-3 2016.1

Clinical usefulness of WT1 mRNA expression in bone marrow detected by a new WT1 mRNA assay kit for monitoring acute myeloid leukemia: a comparison with expression of WT1 mRNA in peripheral blood. Reviewed

Kitamura K, Nishiyama T, Ishiyama K, Miyawaki S, Miyazaki K, Suzuki K, Masaie H, Okada M, Ogawa H, Imai K, Kiyoi H, Naoe T, Yokoyama Y, Chiba S, Hata T, Miyazaki Y, Hatta Y, Takeuchi J, Nannya Y, Kurokawa M, Ueda Y, Koga D, Sugiyama H, Takaku F.

Int J Hematol. Vol. 103 ( 1 ) page： 53-62 2016.1

High-dose chemotherapy followed by autologous stem cell transplantation for relapsed/refractory primary mediastinal large B-cell lymphoma. Reviewed Open Access

Aoki T, Shimada K, Suzuki R, Izutsu K, Tomita A, Maeda Y, Takizawa J, Mitani K, Igarashi T, Sakai K, Miyazaki K, Mihara K, Ohmachi K, Nakamura N, Takasaki H, Kiyoi H, Nakamura S, Kinoshita T, Ogura M.

Blood Cancer J. Vol. 5 page： e372 2015.12

Overview: A New Era of Cancer Genome in Myeloid Malignancies. Invited Reviewed

Kiyoi H.

Oncology. Vol. 89 ( Suppl 1 ) page： 1-3 2015.11

Phase I trial of volasertib, a Polo-like kinase inhibitor, in Japanese patients with acute myeloid leukemia. Reviewed Open Access

Kobayashi Y, Yamauchi T, Kiyoi H, Sakura T, Hata T, Ando K, Watabe A, Harada A, Taube T, Miyazaki Y, Naoe T.

Cancer Sci. Vol. 106 ( 11 ) page： 1590-5 2015.11

Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells. Reviewed Open Access

Sugimoto K, Hayakawa F, Shimada S, Morishita T, Shimada K, Katakai T, Tomita A, Kiyoi H, Naoe T.

Sci Rep. Vol. 5 page： 13054 2015

Integration of humoral and cellular HLA-specific immune responses in cord blood allograft rejection. Reviewed

Hanajiri R, Murata M, Sugimoto K, Murase M, Sakemura R, Goto T, Watanabe K, Imahashi N, Terakura S, Ohashi H, Akatsuka Y, Kurahashi S, Miyamura K, Kiyoi H, Nishida T, Naoe T.

Bone Marrow Transplant Vol. 50 page： 1187-94 2015

FLT3 Inhibitors: Recent Advances And Problems For Clinical Application. Invited Reviewed Open Access

Kiyoi H

Nagoya J Med Sci Vol. 77 page： 7-17 2015

Chimerism status after unrelated donor bone marrow transplantation with fludarabine-melphalan conditioning is affected by the melphalan dose and is predictive of relapse. Reviewed

Imahashi N, Ohashi H, Terakura S, Miyao K, Sakemura R, Kato T, Sawa M, Yokohata E, Kurahashi S, Ozawa Y, Nishida T, Kiyoi H, Watamoto K, Kohno A, Kasai M, Kato C, Iida H, Naoe T, Miyamura K, Murata M; for the Nagoya Blood and Marrow Transplantation Group.

Ann Hematol Vol. 94 page： 1139-48 2015

Simple and Efficient Generation of Virus-specific T Cells for Adoptive Therapy Using Anti-4-1BB Antibody. Reviewed

Imahashi N, Nishida T, Goto T, Terakura S, Watanabe K, Hanajiri R, Sakemura R, Imai M, Kiyoi H, Naoe T, Murata M.

J Immunother. Vol. 38 page： 62-70 2015

Target Antigen Density Governs the Efficacy of Anti-CD20-CD28-CD3 ζ Chimeric Antigen Receptor-Modified Effector CD8+ T Cells. Reviewed

Watanabe K, Terakura S, Martens AC, van Meerten T, Uchiyama S, Imai M, Sakemura R, Goto T, Hanajiri R, Imahashi N, Shimada K, Tomita A, Kiyoi H, Nishida T, Naoe T, Murata M.

J Immunol. Vol. 194 page： 911-20 2015

Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group. Reviewed Open Access

Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T; Japan Adult Leukemia Study Group (JALSG).

Blood Cancer J. Vol. 4 page： e252 2014.10

Efficacy of ofatumumab against rituximab-resistant B-CLL/SLL cells with low CD20 protein expression. Reviewed

Shimada K, Tomita A, Saito S, Kiyoi H.

Br J Haematol Vol. 166 page： 455-457 2014

Expression of CD56 is an unfavorable prognostic factor for acute promyelocytic leukemia with higher initial white blood cell counts. Reviewed Open Access

Ono T, Takeshita A, Kishimoto Y, Kiyoi H, Okada M, Yamauchi T, Emi N, Horikawa K, Matsuda M, Shinagawa K, Monma F, Ohtake S, Nakaseko C, Takahashi M, Kimura Y, Iwanaga M, Asou N, Naoe T; The Japan Adult Leukemia Study Group.

Cancer Sci Vol. 105 page： 97-104 2014

De novo diffuse large B-cell lymphoma with a CD20 immunohistochemistry-positive and flow cytometry-negative phenotype: Molecular mechanisms and correlation with rituximab sensitivity. Reviewed Open Access

Tokunaga T, Tomita A, Sugimoto K, Shimada K, Iriyama C, Hirose T, Shirahata-Adachi M, Suzuki Y, Mizuno H, Kiyoi H, Asano N, Nakamura S, Kinoshita T, Naoe T.

Cancer Sci Vol. 105 page： 35-43 2014

The demarcation between younger and older acute myeloid leukemia patients: a pooled analysis of 3 prospective studies. Reviewed

Yanada M, Ohtake S, Miyawaki S, Sakamaki H, Sakura T, Maeda T, Miyamura K, Asou N, Oh I, Miyatake J, Kanbayashi H, Takeuchi J, Takahashi M, Dobashi D, Kiyoi H, Miyazaki Y, Emi N, Kobayashi Y, Ohno R, Naoe T.

Cancer ( 119 ) page： in press 2013

GATA2 zinc finger 2 mutation found in acute myeloid leukemia impairs myeloid differentiation. Reviewed

Niimi K, Kiyoi H, Ishikawa Y, Hayakawa F, Kurahashi S, Kihara R, Tomita A and Naoe T.

Leukemia Research Reports Vol. 2 page： 21-25 2013

Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation. Reviewed Open Access

Ando K, Tsushima H, Matsuo E, Horio K, Tominaga-Sato S, Imanishi D, Imaizumi Y, Iwanaga M, Itonaga H, Yoshida S, Hata T, Moriuchi R, Kiyoi H, Nimer S, Mano H, Naoe T, Tomonaga M, Miyazaki Y.

J Biol Chem Vol. 288 page： 9457-9467 2013

Gene mutations of acute myeloid leukemia in the genome era. Invited Reviewed Open Access

Naoe T, Kiyoi H

Int J Hematol Vol. 97 page： 165-174 2013

Role of hematopoietic stem cell transplantation for relapsed acute promyelocytic leukemia: a retrospective analysis of JALSG-APL97. Reviewed Open Access

Fujita H, Asou N, Iwanaga M, Hyo R, Nomura S, Kiyoi H, Okada M, Inaguma Y, Matsuda M, Yamauchi T, Ohtake S, Izumi T, Nakaseko C, Ishigatsubo Y, Shinagawa K, Takeshita A, Miyazaki Y, Ohnishi K, Miyawaki S, Naoe T; Japan Adult Leukemia Study Group.

Cancer Sci Vol. 104 page： 1339-45 2013

Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) in acute promyelocytic leukemia. Invited Reviewed Open Access

Tomita A, Kiyoi H, Naoe T.

Int J Hematol Vol. 97 page： 717-725 2013

Guest editorial: efficacy of and resistance to molecularly targeted therapy for myeloid malignancies. Invited Reviewed Open Access

Kiyoi H.

Int J Hematol Vol. 97 page： 681-682 2013

Long-term outcome and prognostic factors of elderly patients with acute promyelocytic leukemia. Reviewed Open Access

Ono T, Takeshita A, Kishimoto Y, Kiyoi H, Okada M, Yamauchi T, Tsuzuki M, Horikawa K, Matsuda M, Shinagawa K, Monma F, Ohtake S, Nakaseko C, Takahashi M, Kimura Y, Iwanaga M, Asou N, Naoe T.

Cancer Sci Vol. 103 ( 11 ) page： 1974-1978 2012

Molecular lesions in childhood and adult acute megakaryoblastic leukaemia.

Hama A, Muramatsu H, Makishima H, Sugimoto Y, Szpurka H, Jasek M, O'Keefe C, Takahashi Y, Sakaguchi H, Doisaki S, Shimada A, Watanabe N, Kato K, Kiyoi H, Naoe T, Kojima S, Maciejewski JP.

Br J Haematol Vol. 156 page： 316-325 2012

Y654 of β-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of β-catenin. Reviewed

Kajiguchi T, Katsumi A, Tanizaki R, Kiyoi H, Naoe T

Eur J Haematol Vol. 88 page： 314-20 2012

Long-term outcome of imatinib therapy, with assessment of its dosage and blood levels, for chronic myelogenous leukemia. Reviewed

Ohnishi K, Nakaseko C, Takeuchi J, Fujisawa S, Nagai T, Yamazaki H, Tauchi T, Imai K, Mori N, Yagasaki F, Maeda Y, Usui N, Miyazaki Y, Miyamura K, Kiyoi H, Ohtake S, Naoe T.

Cancer Sci Vol. 103 page： 1071-1078 2012

Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome. Reviewed

Iriyama C, Tomita A, Hoshino H, Shirahata M, Furukawa-Hibi Y, Yamada K, Kiyoi H, Naoe T.

Biochem Biophys Res Commun Vol. 419 page： 662-9 2012

CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-737. Reviewed Open Access

Shimada K, Tomita A, Minami Y, Abe A, Hind CK, Kiyoi H, Cragg MS, Naoe T.

Exp Hematol Vol. 40 page： 724-737 2012

Randomized comparison of fixed-schedule versus response-oriented individualized induction therapy and use of ubenimex during and after consolidation therapy for elderly patients with acute myeloid leukemia: the JALSG GML200 Study. Reviewed

Wakita A, Ohtake S, Takada S, Yagasaki F, Komatsu H, Miyazaki Y, Kubo K, Kimura Y, Takeshita A, Adachi Y, Kiyoi H, Yamaguchi T, Yoshida M, Ohnishi K, Miyawaki S, Naoe T, Ueda R, Ohno R.

Int J Hematol Vol. 96 page： 84-93 2012

Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia. Reviewed

Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Mori-Ezaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S.

Blood Vol. 120 page： 1485-8 2012

Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: JALSG AML201 Study. Reviewed

Ohtake S, Miyawaki S, Fujita H, Kiyoi H, Shinagawa K, Usui N, Okumura H, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R.

Blood Vol. 117 ( 117 ) page： 2358-2365 2011

FLT3/ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signaling. Reviewed

Katsumi A, Kiyoi H, Abe A, Tanizaki R, Iwasaki T, Kobayashi M, Matsushita T, Senga T, Kohno T, Kojima T, Kaibuchi K, Hamaguchi M, Naoe T.

Eur J Haematol Vol. 86 page： 191-198 2011

A novel insertion mutation of K294RGG within BCR-ABL kinase domain confers imatinib-resistance: sequential analysis of the clonal evolution in a patient with chronic myeloid leukemia in blast crisis. Reviewed

Sakai K, Ishikawa Y, Mori Y, Kobayashi M, Iriyama C, Ozawa Y, Suzuki T, Minami Y, Ishikawa K, Kaneda N, Naoe T, Kiyoi H.

Int J Hematol Vol. 93 page： 237-242 2011

Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. Reviewed

Katsumi A, Nishida T, Murata M, Terakura S, Shimada K, Saito S, Kobayashi M, Kodaira A, Shibata S, Oda I, Yagi T, Kiyoi H, Matsushita T, Kojima T, Naoe T.

J Clin Exp Hematop Vol. 51 page： 63-65 2011

Phase I trial of gemtuzumab ozogamicin in intensive combination chemotherapy for relapsed or refractory adult acute myeloid leukemia (AML): Japan Adult Leukemia Study Group (JALSG)-AML206 study. Reviewed Open Access

Usui N, Takeshita A, Nakaseko C, Dobashi N, Fujita H, Kiyoi H, Kobayashi Y, Sakura T, Yahagi Y, Shigeno K, Ohwada C, Miyazaki Y, Ohtake S, Miyawaki S, Naoe T, Ohnishi K

Cancer Sci Vol. 102 page： 1358-1365 2011

Prevalence and clinical characteristics of N-terminally truncated WT1 expression in acute myeloid leukemia. Reviewed

Ishikawa Y, Kiyoi H, Naoe T.

Leuk Res Vol. 35 page： 685-688 2011

A randomized comparison of four courses of standard-dose multiagent chemotherapy versus three courses of high-dose cytarabine alone in post-remission therapy for acute myeloid leukemia in adults: the JALSG AML201 study. Reviewed

Miyawaki S, Ohtake S, Fujisawa S, Kiyoi H, Shinagawa K, Usui N, Sakura T, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R.

Blood Vol. 117 page： 2366-2372 2011

Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia: a report from the BINGO study. Reviewed Open Access

Ishikawa Y, Kiyoi H, Watanabe K, Miyamura K, Nakano Y, Kitamura K, Kohno A, Sugiura I, Yokozawa T, Hanamura A, Yamamoto K, Iida H, Emi N, Suzuki R, Ohnishi K, Naoe T.

Cancer Sci Vol. 101 page： 2186-2192 2010.10

Imatinib for newly diagnosed chronic-phase chronic myeloid leukemia: results of a prospective study in Japan. Reviewed

Nagai T, Takeuchi J, Dobashi N, Kanakura Y, Taniguchi S, Ezaki K, Nakaseko C, Hiraoka A, Okada M, Miyazaki Y, Motoji T, Higashihara M, Tsukamoto N, Kiyoi H, Nakao S, Shinagawa K, Ohno R, Naoe T, Ohnishi K, Usui N.

Int J Hematol Vol. 92 page： 111-117 2010.7

Array-based genomic resequencing of human leukemia. Reviewed

Yamashita Y, Yuan J, Suetake I, Suzuki H, Ishikawa Y, Choi YL, Ueno T, Soda M, Hamada T, Haruta H, Takada S, Miyazaki Y, Kiyoi H, Ito E, Naoe T, Tomonaga M, Toyota M, Tajima S, Iwama A, Mano H.

Oncogene Vol. 29 page： 3723-3731 2010.6

BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4. Reviewed

Suzuki M, Abe A, Imagama S, Nomura Y, Tanizaki R, Minami Y, Hayakawa F, Ito Y, Katsumi A, Yamamoto K, Emi N, Kiyoi H, Naoe T.

Eur J Haematol Vol. 84 page： 229-238 2010

Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia. Reviewed

Tsujimura A, Kiyoi H, Shiotsu Y, Ishikawa Y, Mori Y, Ishida H, Toki T, Ito E, Naoe T.

Int J Hematol Vol. 92 2010

Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. Reviewed Open Access

Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R.

J Clin Oncol Vol. 28 page： 1591-1598 2010

Randomized trial of response-oriented individualized versus fixed-schedule induction chemotherapy with idarubicin and cytarabine in adult acute myeloid leukemia: the JALSG AML95 study. Reviewed

Ohtake S, Miyawaki S, Kiyoi H, Miyazaki Y, Okumura H, Matsuda S, Nagai T, Kishimoto Y, Okada M, Takahashi M, Handa H, Takeuchi J, Kageyama S, Asou N, Yagasaki F, Maeda Y, Ohnishi K, Naoe T, Ohno R.

Int J Hematol Vol. 91 page： 276-283 2010

Irrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD / SCID / IL-2Rgammac mice. Reviewed

Tanizaki R, Nomura Y, Miyata Y, Minami Y, Abe A, Hanamura A, Sawa M, Murata M, Kiyoi H, Matsushita T, Naoe T.

Cancer Sci Vol. 101 page： 631-638 2010

Expanded distribution of the T315I mutation among hematopoietic stem cells and progenitors in a chronic myeloid leukemia patient during imatinib treatment. Reviewed

Minami Y, Kajiguchi T, Abe A, Ohno T, Kiyoi H, Naoe T.

Int J Hematol Vol. 92 page： 664-666 2010

Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance. Reviewed Open Access

Hiraga J, Tomita A, Sugimoto T, Shimada K, Ito M, Nakamura S, Kiyoi H, Kinoshita T, Naoe T.

Blood Vol. 113 page： 4885-4893 2009

Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD. Reviewed

Inamoto Y, Murata M, Katsumi A, Kuwatsuka Y, Tsujimura A, Ishikawa Y, Sugimoto K, Onizuka M, Terakura S, Nishida T, Kanie T, Taji H, Iida H, Suzuki R, Abe A, Kiyoi H, Matsushita T, Miyamura K, Kodera Y, Naoe T.

Bone Marrow Transplant Vol. 45 page： 363-369 2009

Escape mechanisms from antibody therapy to lymphoma cells: downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation. Reviewed Open Access

Sugimoto T, Tomita A, Hiraga J, Shimada K, Kiyoi H, Kinoshita T, Naoe T.

Biochem Biophys Res Commun Vol. 390 page： 48-53 2009

CMC-544 (inotuzumab ozogamicin) shows less effect on multidrug resistant cells: analyses in cell lines and cells from patients with B-cell chronic lymphocytic leukaemia and lymphoma. Reviewed

Takeshita A, Shinjo K, Yamakage N, Ono T, Hirano I, Matsui H, Shigeno K, Nakamura S, Tobita T, Maekawa M, Ohnishi K, Sugimoto Y, Kiyoi H, Naoe T, Ohno R.

Br J Haematol Vol. 146 page： 34-43 2009

CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells. Reviewed

Takeshita A, Yamakage N, Shinjo K, Ono T, Hirano I, Nakamura S, Shigeno K, Tobita T, Maekawa M, Kiyoi H, Naoe T, Ohnishi K, Sugimoto Y, Ohno R.

Leukemia Vol. 23 page： 1329-1336 2009

Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia. Reviewed

Ishikawa Y, Kiyoi H, Tsujimura A, Miyawaki S, Miyazaki Y, Kuriyama K, Tomonaga M, Naoe T.

Eur J Haematol Vol. 83 page： 90-98 2009

Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome. Reviewed Open Access

10. Xu J, Suzuki M, Niwa Y, Hiraga J, Nagasaka T, Ito M, Nakamura S, Tomita A, Abe A, Kiyoi H, Kinoshita T, Naoe T.

Br J Haematol. Vol. 140 page： 394-401 2008

Prognostic implication and biological roles of RhoH in acute myeloid leukaemia. Reviewed

Iwasaki T, Katsumi A, Kiyoi H, Tanizaki R, Ishikawa Y, Ozeki K, Kobayashi M, Abe A, Matsushita T, Watanabe T, Amano M, Kojima T, Kaibuchi K, Naoe T.

Eur J Haematol Vol. 81 page： 454-460 2008

Mutational analysis of SOS1 gene in acute myeloid leukemia. Reviewed

Tanizaki R, Katsumi A, Kiyoi H, Kunishima S, Iwasaki T, Ishikawa Y, Kobayashi M, Abe A, Matsushita T, Watanabe T, Kojima T, Kaibuchi K, Kojima S, Naoe T.

Int J Hematol Vol. 88 2008

Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors. Reviewed

Ishida H, Isami S, Matsumura T, Umehara H, Yamashita Y, Kajita J, Fuse E, Kiyoi H, Naoe T, Akinaga S, Shiotsu Y, Arai H.

Bioorg Med Chem Lett. Vol. 18 page： 5472-5477 2008

Clinical significance of minimal residual disease in patients with t(8;21) acute myeloid leukemia in Japan. Reviewed

Narimatsu H, Iino M, Ichihashi T, Yokozawa T, Hayakawa M, Kiyoi H, Takeo T, Sawamoto A, Iida H, Tsuzuki M, Yanada M, Naoe T, Suzuki R, Sugiura I.

Int J Hematol Vol. 88 2008

Karyotypically independent clones with del(11q) and trisomy 10 in acute myeloid leukemia: trisomy 10 may appear as an additional change. Reviewed

Gotoh M, Sasaki Y, Iguchi T, Fujimoto H, Kodama A, Kiyoi H, Naoe T, Ohyashiki K.

Int J Hematol Vol. 88 page： 123-124 2008

Donor cell leukemia after allogeneic peripheral blood stem cell transplantation: a case report and literature review. Reviewed

Murata M, Ishikawa Y, Ohashi H, Terakura S, Ozeki K, Kiyoi H, Naoe T.

Int J Hematol Vol. 88 page： 111-115 2008

Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome. Reviewed

Sato T, Toki T, Kanezaki R, Xu G, Terui K, Kanegane H, Miura M, Adachi S, Migita M, Morinaga S, Nakano T, Endo M, Kojima S, Kiyoi H, Mano H, Ito E.

Br J Haematol. Vol. 141 page： 681-688 2008

Mutations of JAK2, JAK3 and GATA1 in acute megakaryoblastic leukemia of Down syndrome. Reviewed Open Access

8. Hama A, Yagasaki H, Takahashi Y, Matsumoto K, Kiyoi H, Kojima S.

Blood Vol. 111 page： 2493-2494 2008

Clinical characteristics and outcomes in patients with t(8;21) acute myeloid leukemia in Japan. Reviewed

9. Narimatsu H, Yokozawa T, Iida H, Tsuzuki M, Hayakawa M, Takeo T, Iino M, Ichihashi T, Kato C, Sawamoto A, Sao H, Yanada M, Emi N, Kiyoi H, Yamaguchi T, Naoe T, Suzuki R, Sugiura I.

Leukemia Vol. 22 page： 432-434 2008

Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy. Reviewed Open Access

Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CH, Wang JY, Naoe T.

Int J Hematol Vol. 88 page： 471-475 2008

Clinical features and outcome of T-lineage acute lymphoblastic leukemia in adults: A low initial white blood cell count, as well as a high count predict decreased survival rates. Reviewed

Yanada M, Jinnai I, Takeuchi J, Ueda T, Miyawaki S, Tsuzuki M, Hatta Y, Usui N, Wada H, Morii T, Matsuda M, Kiyoi H, Okada M, Honda S, Miyazaki Y, Ohno R, Naoe T.

Leukemia Res Vol. 31 2007

LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). Reviewed

Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T.

Eur J Haematol. Vol. 78 2007

FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells. Reviewed

Kajiguchi T, Chung EJ, Lee S, Stine A, Kiyoi H, Naoe T, Levis MJ, Neckers L, Trepel JB.

Leukemia Vol. 21 2007

Clinical characteristics and outcomes in patients with t(8;21) acute myeloid leukemia in Japan. Reviewed

Narimatsu H, Yokozawa T, Iida H, Tsuzuki M, Hayakawa M, Takeo T, Iino M, Ichihashi T, Kato C, Sawamoto A, Sao H, Yanada M, Emi N, Kiyoi H, Yamaguchi T, Naoe T, Suzuki R, Sugiura I.

Leukemia Vol. 21 2007

High incidence of secondary failure of platelet recovery after autologous and syngeneic peripheral blood stem cell transplantation in acute promyelocytic leukemia. Reviewed

Narimatsu H, Emi N, Kohno A, Iwai M, Yanada M, Yokozawa T, Saito S, Shimada K, Kiyoi H, Naoe T, Yamamoto K, Morishita Y.

Bone Marrow Transplant Vol. 40 2007

Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma. Reviewed

Hiraga J, Katsumi A, Iwasaki T, Abe A, Kiyoi H, Matsushita T, Kinoshita T, Naoe T.

Leukemia Vol. 21 2007

Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice. Reviewed

Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T.

Leukemia Vol. 21 page： 136 2007

Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD. Reviewed

Okamoto M, Hayakawa F, Miyata Y, Watamoto K, Emi N, Abe A, Kiyoi H, Towatari M, Naoe T.

Leukemia Vol. 21 page： 403 2007

JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults. Reviewed

Kiyoi H, Yamaji S, Kojima, Naoe T.

Leukemia Vol. 21 page： 574 2007

Epegenetic regulation of CD20 protein expression in a novel B-cell lymphoma cell line, RRBL1, established from a patient treated repeatedly with Rituximab-containing chemotherapy. Reviewed

Tomita A, Hiraga J, Kiyoi H, Ninomiya M, Sugimoto T, Ito M, Kinoshita T, Naoe T.

Int J Hematol Vol. 84 2007

A novel FLT3 inhibitor FI-700 selectively suppress the growth of leukemia cells with FLT3 mutations. Reviewed

Kiyoi H, Shiotsu Y, Ozeki K, Yamaji S, Kosugi H, Umehara H, Arai H, Ishii K, Akinaga S, Naoe T.

Clin Cancer Res Vol. 13 page： 4575-4582 2007

Successful second cord blood transplantation using fludarabine and cyclophosphamide as a preparative regimen for graft rejection following reduced-intensity cord blood transplantation. Reviewed

Mizutani E, Narimatsu H, Murata M, Tomita A, Kiyoi H, Naoe T.

Bone Marrow Tranaplant Vol. 32 2007

A randomized study with or without intensified maintenance chemotherapy in patients with acute promyelocytic leukemia who have become negative for PML-RAR{alpha} transcript after consolidation therapy: The Japan Adult Leukemia Study Group (JALSG) APL97 study. Reviewed

Asou N, Kishimoto Y, Kiyoi H, Okada M, Kawai Y, Tsuzuki M, Horikawa K, Matsuda M, Shinagawa K, Kobayashi T, Ohtake S, Nishimura M, Takahashi M, Yagasaki F, Takeshita A, Kimura Y, Iwanaga M, Naoe T, Ohno R.

Blood Vol. 107 2007

Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo. Reviewed

Atsumi A, Tomita A, Kiyoi H, Naoe T.

BBRC Vol. 345 page： 1471 2006

Establishment of a myeloid leukemia cell line, TRL-01, with MLL-ENL fusion gene. Reviewed

Ninomiya M, Abe A, Yokozawa T, Ozeki K, Yamamoto K, Ito M, Ito M, Kiyoi H, Emi N, Naoe T.

Cancer Genet Cytogen Vol. 169 page： 1 2006

Nucleophosmin: a versatile molecule associated with hematological malignancies. Reviewed Open Access

Naoe T, Suzuki T, Kiyoi H, Urano T.

Cancer Sci Vol. 97 page： 963 2006

FLT3 mutations in acute myeloid leukemia. Invited Reviewed

Kiyoi H, Naoe T.

Meth Molec Med Vol. 125 page： 189 2006

PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. Reviewed

Yamamoto T, Isomura M, Xu Y, Liang J, Yagasaki H, Kamachi Y, Kudo K, Kiyoi H, Naoe T, Kojma S.

Leukemia Res Vol. 30 page： 1085 2006

Mutations of N-RAS, FLT3 and p53 genes are not involved in the development of acute leukemia transformed from myeloproliferative diseases with JAK2 mutation. Reviewed

Suzuki M, Abe A, Kiyoi H, Murata M, Ito Y, Shimada K, Morishita Y, Kinoshita T, Naoe T.

Leukemia Vol. 20 page： 1168 2006

Micafungin, a novel antifungal agent, as empirical therapy in acute leukemia patients with febrile neutropenia. Reviewed Open Access

Yanada M, Kiyoi H, Murata M, Suzuki M, Iwai M, Yokozawa T, Baba H, Emi N, Naoe T.

Intern Med Vol. 45 page： 259 2006

Biology, clinical relevance, and moleculary targeted therapy in acute leukemia with FLT3 mutations. Invited Reviewed

Kiyoi H, Naoe T.

Int J Hematol Vol. 83 page： 301 2006

Establishment of a Stroma-Dependent Human Acute Myelomonocytic Leukemia Cell Line, NAMO-2, with FLT3 Tandem Duplication. Reviewed

Abe A, Kiyoi H, Ninomiya M, Yamazaki T, Murase T, Ozeki K, Suzuki M, Hayakawa F, Katsumi A, Emi N, Naoe T.

Int J Hematol Vol. 84 page： 328 2006

Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia. Reviewed

Karnan S, Tsuzuki S, Kiyoi H, Tagawa H, Ueda R, Seto M, Naoe T.

Gene Chromosome Canc Vol. 45 page： 420 2006

Disseminated intravascular coagulation in acute leukemia: clinical and laboratory features at presentation. Reviewed

Yanada M, Matsushita T, Suzuki M, Kiyoi H, Yamamoto K, Kinoshita T, Kojima T, Saito H, Naoe T.

Eur J Haematol Vol. 77 page： 282 2006

*Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia. Reviewed

Suzuki T, Kiyoi H, Ozeki K, Tomita A, Yamaji S, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Ueda R, Kinoshita T, Emi N, Naoe T.

Blood Vol. 106 page： 2854 2005

Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome. Reviewed

Iwai M, Kiyoi H, Ozeki K, Kinoshita T, Emi N, Ohno R, Naoe T.

Leukemia Vol. 19 page： 1367 2005

Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis. Reviewed

Yanada M, Matsuo K, Suzuki T, Kiyoi H, Naoe T.

Leukemia Vol. 19 page： 1345 2005

Clinical significance of FLT3 in leukemia. Invited Reviewed

Kiyoi H, Yanada M, Ozeki K.

Int J Hematol Vol. 82 page： 85 2005

BMI-1 Is Highly Expressed in M0-Subtype Acute Myeloid Leukemia. Reviewed

Sawa M, Yamamoto K, Yokozawa T, Kiyoi H, Hishida A, Kajiguchi T, Seto M, Kohno A, Kitamura K, Itoh Y, Asou N, Hamajima N, Emi N, Naoe T.

Int J Hematol Vol. 82 page： 42 2005

Long-term outcomes for unselected patients with acute myeloid leukemia categorized according to the World Health Organization classification: a single-center experience. Reviewed

Yanada M, Suzuki M, Kawashima K, Kiyoi H, Kinoshita T, Emi N, Saito H, Naoe T.

Eur J Haematol Vol. 74 page： 418 2005

*Biological and clinical significance of the FLT3 transcript level in acute myeloid leukemia. Reviewed

Ozeki K, Kiyoi H, Hirose Y, Iwai M, Ninomiya M, Kodera Y, Miyawaki S, Kuriyama K, Shimazaki C, Akiyama H, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Ueda R, Ohno R, Emi N, Naoe T.

Blood Vol. 103 page： 1901 2004

Multiplex real-time RT-PCR for prospective evaluation of WT1 and fusion gene transcripts in newly diagnosed de novo acute myeloid leukemia. Reviewed

Yanada M, Terakura S, Yokozawa T, Yamamoto K, Kiyoi H, Emi N, Kitamura K, Kohno A, Tanaka M, Tobita T, Takeo T, Sao H, Kataoka T, Kobayashi M, Takeshita A, Morishita Y, Sugiura I, Naoe T.

Leukemia Lymphoma Vol. 45 page： 1803 2004

Retinoic acid syndrome in NOD/scid mice induced by injecting an acute promyelocytic leukemia cell line. Reviewed

Ninomiya M, Kiyoi H, Ito M, Hirose Y, Ito M, Naoe T.

Leukemia Vol. 18 page： 442 2004

Normal and oncogenic FLT3. Invited Reviewed Open Access

Naoe T, Kiyoi H.

Cell Mol Life Sci Vol. 61 page： 2932 2004

Different anti-apoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia. Reviewed

Minami Y, Yamamoto K, Kiyoi H, Ueda R, Saito H, Naoe T.

Blood Vol. 102 page： 2969 2003

Comprehensive analysis of gene alterations in acute megakaryoblastic leukemia of Down syndrome. Reviewed

Hirose Y, Kudo K, Kiyoi H, Hayashi Y, Naoe T, Kojima S.

Leukemia Vol. 17 page： 2250 2003

A xeno-transplantable plasma cell leukemia line with a split translocation of the IgH gene. Reviewed

Ohbayashi K, Taniwaki M, Ninomiya M, Kiyoi H, Iida S, Ueda R, Naoe T.

Cancer Genet Cytogen Vol. 144 page： 31 2003

Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy Reviewed

Leukemia Vol. 16 page： 203-208 2002

FLT3 in human hematologic malignancies. Invited Reviewed

Kiyoi H, Naoe T.

Leukemia Lymphoma Vol. 43 page： 1541 2002

Rapid screening of leukemia fusion transcripts in acute leukemia by Real-time PCR. Reviewed

Osumi K, Fukui T, Kiyoi H, Kasai M, Kodera Y, Kudo K, Kato K, Matsuyama M, Naito K, Tamimoto M, Hirai H, Saito H, Ohno R, Naoe T.

Leukemia Lymphoma Vol. 43 page： 2291 2002

Disruption of the RanBP17/Hox11L2 region by recombination with the TCRdelta locus in acute lymphoblastic leukemias with t(5;14)(q34;q11 Reviewed

Leukemia Vol. 16 page： 2205-2212 2002

Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors Reviewed

Leukemia Vol. 16 page： 1535-1540 2002

Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain Reviewed

Kiyoi H, Ohno R, Ueda R, Saito H, Naoe T.

Oncogene Vol. 21 page： 2555-2563 2002

Successful treatment with imatinib mesylate of a CML patient in megakaryoblastic crisis with severe fibrosis. Reviewed

Hirose Y, Kiyoi H, Iwai M, Yokozawa T, Ito M, Naoe T.

Int J Hematol Vol. 76 page： 349 2002

Ectopic expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations Reviewed Open Access

Jpn J Cancer Res Vol. 92 page： 638-644 2001

B-cell precursors differentiated from cord blood CD34+ cells are more immature than those derived from granulocyte colony-stimulating factor-mobilized peripheral blood CD34+ cells Reviewed Open Access

Immunology Vol. 104 page： 410-417 2001

FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy Reviewed

Cancer Chemother Pharmacol Vol. 48 page： 27-30 2001

Immunoglobulin variable region structure and B cell malignancies. Reviewed

Kiyoi H, Naoe T.

Int J Hematol Vol. 73 page： 47 2001

Prognostic significance of the cell cycle inhibitor p27Kip1 in acute myeloid leukemia.

Leukemia Vol. 14 page： 28-33 2000

Leukemia relapse reconsidered from the molecular aspect.

Leukemia and Lymphoma Vol. 37 page： 527-534 2000

Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid. Open Access

Br J Haematol Vol. 108 page： 696-702 2000

Identification of a novel putative Ran-binding protein and its close homologue

Biochem Biophys Res Commun Vol. 278 page： 241-249 2000

Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia. Reviewed

Clin Cancer Res Vol. 6 page： 4091-4095 2000

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Reviewed

Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H, Naoe T.

Oncogene Vol. 19 page： 624-631 2000

Prognostic value of p53 gene mutations and the product expression in de novo acute myeloid leukemia.

Eur J Haematol Vol. 65 page： 23-31 2000

In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor.

Leukemia Vol. 14 page： 374-378 2000

Poor clinical significance of p53 gene polymorphism in acute myeloid leukemia.

Leuk Res Vol. 24 page： 349-352 2000

Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis. Reviewed

Kitamura K, Minami Y, Yamamoto K, Akao Y, Kiyoi H, Saito H, Naoe T.

Leukemia Vol. 14 page： 1743 2000

Accurate quantitation of residual tumor burden at bone marrow harvest predicts timing of subsequent relapse in patients with common ALL treated by autologous bone marrow transplantation. Nagoya BMT Group.

Bone Marrow Transplant Vol. 24 page： 777-784 1999

Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy.

Leukemia Vol. 13 page： 1316-1324 1999

Molecular evolution of acute myeloid leukaemia in relapse : unstable N-ras and FLT3 genes compared with p53 gene.

Br J Haematol Vol. 104 page： 659-664 1999

Review of the immunoglobulin light chain variable region sequences from multiple myeloma cells.

Leukemia Vol. 13 page： 829-830 1999

Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation.

Leukemia Vol. 13 page： 585-589 1999

Etoposide-realted acute promyelocytic leukemia.

Leukemia Vol. 12 page： 1171-1175 1998

Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia. Open Access

Br J Haematol Vol. 101 page： 521-528 1998

Characterization of the immunoglobulin light chain variable region gene expressed in multiple myeloma.

Leukemia Vol. 12 page： 601-609 1998

Prognostic significance of TEL/AML1 fusion transcript in childhood B-precursor acute lymphoblastic leukemia.

J Pediatr Hematolo/oncolo Vol. 20 page： 190-195 1998

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines.

Leukemia Vol. 11 page： 1605-1609 1997

Mutant AF-2 domain of PML-RARα in retinoic acid-resistant NB4 cells : differentiation induced by RA is triggered directly through PML-RARα and its down-regulation in acute promyelocytic leukemia.

Leukemia Vol. 11 page： 1950-1956 1997

Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia.

Leukemia Vol. 11 page： 1447-1452 1997

Unusual feature of the T-cell receptor genes in T-lineage acute lymphoblastic leukemia.

Leuk Res Vol. 21 page： 667-674 1997

New retinoids and arsenic compounds for the treatment of refractory acute promyelocytic leukemia : clinical and basic studies for the next generation.

Cancer Chemotherapy & Pharmacology Vol. 40 page： S36-S41 1997

Comparison of the immunoglobulin gene transcripts between immature B lineage acute lymphoblastic leukemia and the normal phenotypic counterparts in the bone marrow.

Leukemia Vol. 11 page： 1274-1280 1997

Comparable gene structure of the immunoglobulin heavy chain variable region between multiple myeloma and normal bone marrow lymphocytes.

Leukemia Vol. 10 page： 1804-1812 1996

Different T-cell receptor repertoires between lesions and peripheral blood in acute graft-versus-host disease after allogeneic bone marrow transplantation. Open Access

Blood Vol. 87 page： 3019-3026 1996

Comparison of the immunoglobulin heavy-chain complementarity determining region-3 structure among the DNA sequences and the μ-and γ-transcripts in human B-lineage cells.

Immunology Vol. 89 page： 324-330 1996

Comparable profiles of the immunoglobulin heavy chain complementarity determining region(CDR)-3 in CD5₊ and CD5_- human cord blood B lymphocytes.

Immunology Vol. 85 page： 236-240 1995

Detection of minimal residual disease in patients with childhood common acute lymphoblastic leukemia after autologous bone marrow trasplantation with ex vivo purging and systemic IL-2 infusion : unsuccessful prediction of subsequent relapse.

Bone Marrow Transplant Vol. 16 page： 437-442 1995

Continuing immunoglobulin heavy chain gene rearrangements in chronic myeloid leikemia with recurrent B-lymphoid blast crises after bone marrow transplantation.

Leukemia Vol. 9 page： 265-270 1995

Analysis of the joining sequences of the t(15 ; 17)translocation in human acute pronyelocytic leukemia : sequence non-specific recombination between the PML and RARA genes within identical short stretches.

Genes, Chromosomes & Cancer Vol. 12 page： 37-44 1995

Prognostic significance of the RT-PCR assay of PML-RARA trascripts in acute promyelocytic leukemia.

Leukemia Vol. 9 page： 588-593 1995

Characterization of immunoglobulin heavy chain gene rearrangements in chronic myeloid leikemia with recurrent B-lymphoid blast crisis following bone marrow transplantation.

Int Med Vol. 33 page： 786-789 1994

Minimal residual disease status in pre-B acute lymphoblastic leukemia patients after chemotherapy and bone marrow trasplantation : assessment of the antileukemic effects of chemotherapy and BMT.

Leuk Res Vol. 17 page： 674-684 1993

Clonal analysis of multiple point mutations in the N-ras gene in patients with acute myeloid leukemia.

Jap J Cancer Res Vol. 84 page： 379-387 1993

Involvement of the MLL/ALL-1 gene associated with multiple point mutations of the N-ras gene in acute myeloid leukemia with t(11 : 17)(q23 ; q25).

Blood Vol. 82 page： 2260-2261 1993

Effective treatment of adult T cell leukemia/lymphoma with a novel oral antitumor agent, MST-16.

Oncology Vol. 49 page： 333-335 1992

Characterization of the immunoglobulin heavy chain complementarity determining region(CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells. Reviewed

J Clin Invest Vol. 89 page： 739-746 1992

Hermolytic uraemic syndrome during FK506 therapy.

Lancet Vol. 340 page： 60-61 1992

Development of hyperthyroidism in donor and recipient after allogeneic bone marrow transplantation.

Bone Marrow Transplant Vol. 10 page： 397-398 1992

Disappearance of minimal residual lymphoblastic leukemia cells 6 months after allogeneic bone marrow transplantation without GVHD. Reviewed

Bone Marrow Transplant Vol. 8 page： 59-62 1991

A case of cALL relapse after allogeneic BMT : recurrence of recipient cell origin, initially determined as being that of donor cell origin by sex chromosome analysis. Reviewed

Br J Haematolo Vol. 73 page： 420-422 1989

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