Faculty Profiles - HAYASHI, Yoshitaka

Papers - HAYASHI, Yoshitaka

Division display 21 - 40 of about 111 ／ All the affair displays >>

Sphingosine kinase 1–interacting protein is a dual regulator of insulin and incretin secretion Reviewed Open Access

Yanyan Liu, Shin Ichi Harashima, Yu Wang, Kazuyo Suzuki, Shinsuke Tokumoto, Ryota Usui, Hisato Tatsuoka, Daisuke Tanaka, Daisuke Yabe, Norio Harada, Yoshitaka Hayashi, Nobuya Inagaki

FASEB Journal Vol. 33 ( 5 ) page： 6239 - 6253 2019.5

Language：Japanese Publishing type：Research paper (scientific journal)

© FASEB Our previous study demonstrated that sphingosine kinase 1–interacting protein (SKIP, or Sphkap) is expressed in pancreatic β-cells, and depletion of SKIP enhances glucose-stimulated insulin secretion. We find here that SKIP is also expressed in intestinal K- and L-cells and that secretion of gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) as well as insulin are significantly increased, and blood glucose levels are decreased in SKIP-deficient (SKIP−/−) mice compared with those in wild-type mice. Plasma triglyceride (Tg), LDL cholesterol, and mRNA levels of proinflammatory cytokines in adipose tissues, livers, and intestines were found to be significantly decreased in SKIP−/− mice. The phenotypic characteristics of SKIP−/− mice, including adiposity and attenuation of basal inflammation, were abolished by genetic depletion of GIP. The improvement of glucose tolerance and lipid profiles in SKIP−/− mice were cancelled by GLP-1 receptor antagonist exendin-(9–39) treatment. In summary, depletion of SKIP ameliorates glucose tolerance by enhancing secretion of insulin and incretins, improves lipid metabolism, and reduces basal inflammation levels. Thus, inhibition of SKIP action may emerge as a new option for treatment of type 2 diabetes mellitus with metabolic dysfunction.—Liu, Y., Harashima, S., Wang, Y., Suzuki, K., Tokumoto, S., Usui, R., Tatsuoka, H., Tanaka, D., Yabe, D., Harada, N., Hayashi, Y., Inagaki, N. Sphingosine kinase 1–interacting protein is a dual regulator of insulin and incretin secretion. FASEB J. 33, 6239–6253 (2019). www.fasebj.org.

DOI： 10.1096/fj.201801783RR

Web of Science

Scopus

PubMed

Two Mutations in Thyroid Hormone Receptor Beta Gene (P453A and C36Y) in a Family with Resistance to Thyroid Hormone with Comorbid Myotonic Dystrophy. Reviewed

Takeda K, Nemoto KI, Hayashi Y, Yamamoto M, Sakuta R, Kimura T, Noto H

Thyroid : official journal of the American Thyroid Association Vol. 29 ( 4 ) page： 607 - 608 2019.4

The Mutant Thyroid Hormone Receptor Beta R320P Causes Syndrome of Resistance to Thyroid Hormone Reviewed

Kimura Tetsuya, Hayashi Yoshitaka, Tsukamoto Yuka, Okamoto Yasuyuki

CASE REPORTS IN ENDOCRINOLOGY Vol. 2018 page： 4081769 2018

Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice. Reviewed

Ryuya Maekawa, Yusuke Seino, Hidetada Ogata, Masatoshi Murase, Atsushi Iida, Kaori Hosokawa, Erina Joo, Norio Harada, Shin Tsunekawa, Yoji Hamada, Yutaka Oiso, Nobuya Inagaki, Yoshitaka Hayashi, Hiroshi Arima

J Nutr Biochem Vol. 49 page： 71-79 2017.11

Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice Reviewed Open Access

Maekawa, R; Seino, Y; Ogata, H; Murase, M; Iida, A; Hosokawa, K; Joo, E; Harada, N; Tsunekawa, S; Hamada, Y; Oiso, Y; Inagaki, N; Hayashi, Y; Arima, H

JOURNAL OF NUTRITIONAL BIOCHEMISTRY Vol. 49 page： 71 - 79 2017.11

Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin. Reviewed

Atsushi Iida, Yusuke Seino, Ayako Fukami, Ryuya Maekawa, Daisuke Yabe, Shinobu Shimizu, Keita Kinoshita, Yusuke Takagi, Takako Izumoto, Hidetada Ogata, Kota Ishikawa, Nobuaki Ozaki, Shin Tsunekawa, Yoji Hamada, Yutaka Oiso, Hiroshi Arima, Yoshitaka Hayashi,

Diabetologia Vol. 59 ( 7 ) page： 1533-1541 2016.4

Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity.

Takagi Y, Kinoshita K, Ozaki N, Seino Y, Murata Y, Oshida Y, Hayashi Y.

PLoS One. Vol. 10 ( 9 ) page： e0138322 2015.9

Chronic Hyponatremia Causes Neurologic and Psychologic Impairments.

Fujisawa H, Sugimura Y, Takagi H, Mizoguchi H, Takeuchi H, Izumida H, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Fukumoto K, Iwama S, Takagishi Y, Hayashi Y, Arima H, Komatsu Y, Murata Y, Oiso Y.

J Am Soc Nephrol. page： Epub ahead of print 2015.9

*Pancreatic Neuroendocrine Tumors in Mice Deficient in Proglucagon-Derived Peptides.

Takano Y, Kasai K, Takagishi Y, Kikumori T, Imai T, Murata Y, Hayashi Y.

PLoS ONE Vol. 10 ( 7 ) page： e0133812 2015.7

グルカゴンの真の特異的作用は何か？グルカゴン作用欠損モデルの表現型.

林　良敬

実験医学 Vol. 33 ( 6 ) page： 897-902 2015.4

Low temperature-induced circulating triiodothyronine accelerates seasonal testicular regression. Open Access

K. Ikegami, Y. Atsumi, E. Yonenaga, H. Ono, I. Murayama, Y. Nakane, W. Ota, N. Arai, A. Tega, M. Iigo, V. M. Darras, K. Tsutsui, Y. Hayashi, S. Yoshida, Y. Yoshimura

Endocrinology Vol. 156 ( 2 ) page： 647-659 2015.2

Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion.

Shibue K, Yamane S, Harada N, Hamasaki A, Suzuki K, Joo E, Iwasaki K, Nasteska D, Harada T, Hayashi Y, Adachi Y, Owada Y, Takayanagi R, Inagaki N.

Am J Physiol Endocrinol Metab. Vol. 308 ( 7 ) page： E583-E591 2015.1

Activation of the RhoB signaling pathway by thyroid hormone receptor ß in thyroid cancer cells. Open Access

Ichijo S, Furuya F, Shimura H, Hayashi Y, Takahashi K, Ohta K, Kobayashi T, Kitamura K.

PLoS One Vol. 9 ( 12 ) page： e116252 2014.12

Glucagon is essential for adaptive thermongenesis in brown adipose tissue Reviewed

K. Kinoshita, N. Ozaki, Y. Takagi, Y. Murata, Y. Oshida, Y. Hayashi

Endocrinology Vol. 155 ( 9 ) page： 3484-3492 2014.6

KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state. Reviewed

H. Ogata, Y. Seino, N. Harada, A. Iida, K. Suzuki, T. Izumoto, K. Ishikawa, E. Uenishi, N. Ozaki, Y. Hayashi, T. Miki, N. Inagaki, S. Tsunekawa, Y. Hamada, S. Seino, Y. Oiso

Journal of ENdocrinology Vol. 222 ( 2 ) page： 191-200 2014.6

Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice. Open Access

Okawa T, Kamiya H, Himeno T, Seino Y, Tsunekawa S, Hayashi Y, Harada N, Yamada Y, Inagaki N, Seino Y, Oiso Y, Nakamura J.

J Diabetes Investig Vol. 5 ( 1 ) page： 31-37 2013.10

Hyperthyroidism due to thyroid-stimulating hormone secretion after surgery for Cushing's syndrome: a novel cause of the syndrome of inappropriate secretion of thyroid-stimulating hormone. Reviewed Open Access

D. Tamada, T. Onodera, T. Kitamura, Y. Yamamoto, Y. Hayashi, Y. Murata, M. Otsuki, I. Shimomura

J Clin Endocrinol Metab Vol. 98 ( 7 ) page： 2656-2662 2013.5

S. Xu, Y. Hayashi, Y. Takagishi, M. Itoh, Y. Murata

PLoS One Vol. 8 ( 5 ) page： e64415 2013.5

Ectopic expression of GIP in pancreatic ß-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides. Reviewed Open Access

A. Fukami, Y. Seino, N. Ozaki, M. Yamamoto, C. Sugiyama, E. Sakamoto-Miura, T. Himeno, Y. Takagishi, S. Tsunekawa, S. Ali, D. J. Drucker, Y. Murata, Y. Seino, Y. Oiso, Y. Hayashi

Diabetes page： doi: 10.2337/db12-0294 2012.10

グルカゴンによる代謝制御 Invited

林　良敬

糖尿病と代謝 Vol. 40 ( 3 ) page： 1-8 2012.9

　 PREV - NEXT 　

<HAYASHI, Yoshitaka>

Papers - HAYASHI, Yoshitaka