Faculty Profiles - HAYASHI, Yoshitaka

Papers - HAYASHI, Yoshitaka

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Glutaminostatin: Another facet of glucagon as a regulator of plasma amino acid concentrations Reviewed

Hayashi Yoshitaka

JOURNAL OF DIABETES INVESTIGATION Vol. 10 ( 6 ) page： 1391 - 1393 2019.11

*Remodeling of Hepatic Metabolism and Hyperaminoacidemia in Mice Deficient in Proglucagon-derived Peptides. Reviewed

C. Watanabe, Y. Seino, H. Miyahira, M. Yamamoto, A. Fukami, N. Ozaki, Y. Takagishi, J. Sato, T. Fukuwatari, K. Shibata, Y. Oiso, Y. Murata, Y. Hayashi

Diabetes Vol. 61 ( 1 ) page： 74-84 2012.1

*Metabolic impact of glucagon deficiency. Invited Reviewed

Yoshitaka Hayashi

Diabetes, Obesity and Metabolism. Vol. 13 ( suppl 1 ) page： 151-157 2011.10

*Mice Deficient for Glucagon Gene-Derived Peptides Display Normoglycemia, and Hyperplasia of Islet a-Cells but not of Intestinal L-cells. Reviewed

Y. Hayashi, M. Yamamoto, H. Mizoguchi, C. Watanabe, R. Ito, S. Yamamoto, X.Y. Sun, Y. Murata

Mol Endocrinol Vol. 23 ( 12 ) page： 1990-1999 2009.12

Voltage-gated calcium channel α<sub>2</sub>δ-1 subunit is involved in the regulation of glucose-stimulated GLP-1 secretion in mice Reviewed Open Access

Yang, YH; Yamane, S; Harada, N; Ikeguchi-Ogura, E; Yamamoto, K; Wada, N; Fauzi, M; Murakami, T; Yabe, D; Hayashi, Y; Inagaki, N

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY Vol. 328 ( 3 ) page： G243 - G251 2025.3

Superoxide dismutase 2 deficiency in mesenchymal stromal cells induces sympathetic denervation and functional impairment of brown adipose tissue Reviewed Open Access

Urano, Y; Mii, S; Asai, S; Esaki, N; Ando, R; Shiraki, Y; Iida, T; Kato, K; Hori, M; Hayashi, Y; Shimizu, T; Enomoto, A

PATHOLOGY INTERNATIONAL Vol. 75 ( 2 ) page： 69 - 81 2025.2

Advances in basic research on glucagon and alpha cells Reviewed

Hayashi, Y

DIABETOLOGY INTERNATIONAL Vol. 15 ( 3 ) page： 348 - 352 2024.7

Impaired Fat Absorption from Intestinal Tract in High-Fat Diet Fed Male Mice Deficient in Proglucagon-Derived Peptides Reviewed

Nishida, K; Ueno, S; Seino, Y; Hidaka, S; Murao, N; Asano, Y; Fujisawa, H; Shibata, M; Takayanagi, T; Ohbayashi, K; Iwasaki, Y; Iizuka, K; Okuda, S; Tanaka, M; Fujii, T; Tochio, T; Yabe, D; Yamada, Y; Sugimura, Y; Hirooka, Y; Hayashi, Y; Suzuki, A

NUTRIENTS Vol. 16 ( 14 ) 2024.7

Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon-derived peptides Reviewed

Ueno, S; Seino, Y; Hidaka, S; Nakatani, M; Hitachi, K; Murao, N; Maeda, Y; Fujisawa, H; Shibata, M; Takayanagi, T; Iizuka, K; Yabe, D; Sugimura, Y; Tsuchida, K; Hayashi, Y; Suzuki, A

JOURNAL OF DIABETES INVESTIGATION Vol. 14 ( 9 ) page： 1045 - 1055 2023.9

A newly developed glucagon sandwich ELISA is useful for more accurate glucagon evaluation than the currently used sandwich ELISA in subjects with elevated plasma proglucagon-derived peptide levels Reviewed

Kobayashi, M; Maruyama, N; Yamamoto, Y; Togawa, T; Ida, T; Yoshida, M; Miyazato, M; Kitada, M; Hayashi, Y; Kashiwagi, A; Kitamura, T

JOURNAL OF DIABETES INVESTIGATION Vol. 14 ( 5 ) page： 648 - 658 2023.5

An analysis of intestinal morphology and incretin-producing cells using tissue optical clearing and 3-D imaging Reviewed

Hatoko, T; Harada, N; Tokumoto, S; Yamane, S; Ikeguchi-Ogura, E; Kato, T; Yasuda, T; Tatsuoka, H; Shimazu-Kuwahara, S; Yabe, D; Hayashi, Y; Inagaki, N

SCIENTIFIC REPORTS Vol. 12 ( 1 ) page： 17530 2022.10

High Protein Diet Feeding Aggravates Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides Reviewed

Ueno, S; Seino, Y; Hidaka, S; Maekawa, R; Takano, Y; Yamamoto, M; Hori, M; Yokota, K; Masuda, A; Himeno, T; Tsunekawa, S; Kamiya, H; Nakamura, J; Kuwata, H; Fujisawa, H; Shibata, M; Takayanagi, T; Sugimura, Y; Yabe, D; Hayashi, Y; Suzuki, A

NUTRIENTS Vol. 14 ( 5 ) 2022.3

Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids Reviewed

Fujiwara Yuta, Yamane Shunsuke, Harada Norio, Ikeguchi-Ogura Eri, Usui Ryota, Nakamura Toshihiro, Iwasaki Kanako, Suzuki Kazuyo, Yabe Daisuke, Hayashi Yoshitaka, Inagaki Nobuya

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY Vol. 320 ( 4 ) page： G617 - G626 2021.4

Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in -cell Mass Independent of Body Weight Gain in Mice Reviewed

Masuda Atsushi, Seino Yusuke, Murase Masatoshi, Hidaka Shihomi, Shibata Megumi, Takayanagi Takeshi, Sugimura Yoshihisa, Hayashi Yoshitaka, Suzuki Atsushi

NUTRIENTS Vol. 11 ( 5 ) 2019.5

Acute Cholesterol-Lowering Effect of Exendin-4 in Ldlr(-/-) and C57BL/6J Mice. Reviewed

Hori M, Hasegawa Y, Hayashi Y, Nakagami T, Harada-Shiba M

Journal of atherosclerosis and thrombosis 2022.3

Carbohydrate-induced weight gain models for diabetes research: contribution of incretins and parasympathetic signal. Reviewed

Seino Y, Murase M, Hayashi Y, Suzuki A

Journal of diabetes investigation Vol. 12 ( 1 ) page： 3 - 5 2021.1

Glucagon regulates lipolysis and fatty acid oxidation through inositol triphosphate receptor 1 in the liver Reviewed

Hayashi Yoshitaka

JOURNAL OF DIABETES INVESTIGATION Vol. 12 ( 1 ) page： 32 - 34 2021.1

Deficiency of glucagon gene-derived peptides induces peripheral polyneuropathy in mice Reviewed

Motegi Mikio, Himeno Tatsuhito, Nakai-Shimoda Hiromi, Inoue Rieko, Ozeki Norio, Hayashi Yusuke, Sasajima Sachiko, Mohiuddin Mohammad Sarif, Asano-Hayami Emi, Kato Makoto, Asano Saeko, Miura-Yura Emiri, Morishita Yoshiaki, Kondo Masaki, Tsunekawa Shin, Kato Yoshiro, Kato Koichi, Naruse Keiko, Seino Yusuke, Hayashi Yoshitaka, Nakamura Jiro, Kamiya Hideki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 532 ( 1 ) page： 47 - 53 2020.10

Sphingosine kinase 1–interacting protein is a dual regulator of insulin and incretin secretion Reviewed

Yanyan Liu, Shin Ichi Harashima, Yu Wang, Kazuyo Suzuki, Shinsuke Tokumoto, Ryota Usui, Hisato Tatsuoka, Daisuke Tanaka, Daisuke Yabe, Norio Harada, Yoshitaka Hayashi, Nobuya Inagaki

FASEB Journal Vol. 33 ( 5 ) page： 6239 - 6253 2019.5

Language：Japanese Publishing type：Research paper (scientific journal)

© FASEB Our previous study demonstrated that sphingosine kinase 1–interacting protein (SKIP, or Sphkap) is expressed in pancreatic β-cells, and depletion of SKIP enhances glucose-stimulated insulin secretion. We find here that SKIP is also expressed in intestinal K- and L-cells and that secretion of gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) as well as insulin are significantly increased, and blood glucose levels are decreased in SKIP-deficient (SKIP−/−) mice compared with those in wild-type mice. Plasma triglyceride (Tg), LDL cholesterol, and mRNA levels of proinflammatory cytokines in adipose tissues, livers, and intestines were found to be significantly decreased in SKIP−/− mice. The phenotypic characteristics of SKIP−/− mice, including adiposity and attenuation of basal inflammation, were abolished by genetic depletion of GIP. The improvement of glucose tolerance and lipid profiles in SKIP−/− mice were cancelled by GLP-1 receptor antagonist exendin-(9–39) treatment. In summary, depletion of SKIP ameliorates glucose tolerance by enhancing secretion of insulin and incretins, improves lipid metabolism, and reduces basal inflammation levels. Thus, inhibition of SKIP action may emerge as a new option for treatment of type 2 diabetes mellitus with metabolic dysfunction.—Liu, Y., Harashima, S., Wang, Y., Suzuki, K., Tokumoto, S., Usui, R., Tatsuoka, H., Tanaka, D., Yabe, D., Harada, N., Hayashi, Y., Inagaki, N. Sphingosine kinase 1–interacting protein is a dual regulator of insulin and incretin secretion. FASEB J. 33, 6239–6253 (2019). www.fasebj.org.

DOI： 10.1096/fj.201801783RR

Web of Science

Scopus

PubMed

Two Mutations in Thyroid Hormone Receptor Beta Gene (P453A and C36Y) in a Family with Resistance to Thyroid Hormone with Comorbid Myotonic Dystrophy. Reviewed

Takeda K, Nemoto KI, Hayashi Y, Yamamoto M, Sakuta R, Kimura T, Noto H

Thyroid : official journal of the American Thyroid Association Vol. 29 ( 4 ) page： 607 - 608 2019.4

The Mutant Thyroid Hormone Receptor Beta R320P Causes Syndrome of Resistance to Thyroid Hormone Reviewed

Kimura Tetsuya, Hayashi Yoshitaka, Tsukamoto Yuka, Okamoto Yasuyuki

CASE REPORTS IN ENDOCRINOLOGY Vol. 2018 page： 4081769 2018

Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice. Reviewed

Ryuya Maekawa, Yusuke Seino, Hidetada Ogata, Masatoshi Murase, Atsushi Iida, Kaori Hosokawa, Erina Joo, Norio Harada, Shin Tsunekawa, Yoji Hamada, Yutaka Oiso, Nobuya Inagaki, Yoshitaka Hayashi, Hiroshi Arima

J Nutr Biochem Vol. 49 page： 71-79 2017.11

Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice Reviewed

Maekawa, R; Seino, Y; Ogata, H; Murase, M; Iida, A; Hosokawa, K; Joo, E; Harada, N; Tsunekawa, S; Hamada, Y; Oiso, Y; Inagaki, N; Hayashi, Y; Arima, H

JOURNAL OF NUTRITIONAL BIOCHEMISTRY Vol. 49 page： 71 - 79 2017.11

Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin. Reviewed

Atsushi Iida, Yusuke Seino, Ayako Fukami, Ryuya Maekawa, Daisuke Yabe, Shinobu Shimizu, Keita Kinoshita, Yusuke Takagi, Takako Izumoto, Hidetada Ogata, Kota Ishikawa, Nobuaki Ozaki, Shin Tsunekawa, Yoji Hamada, Yutaka Oiso, Hiroshi Arima, Yoshitaka Hayashi,

Diabetologia Vol. 59 ( 7 ) page： 1533-1541 2016.4

Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity.

Takagi Y, Kinoshita K, Ozaki N, Seino Y, Murata Y, Oshida Y, Hayashi Y.

PLoS One. Vol. 10 ( 9 ) page： e0138322 2015.9

Chronic Hyponatremia Causes Neurologic and Psychologic Impairments.

Fujisawa H, Sugimura Y, Takagi H, Mizoguchi H, Takeuchi H, Izumida H, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Fukumoto K, Iwama S, Takagishi Y, Hayashi Y, Arima H, Komatsu Y, Murata Y, Oiso Y.

J Am Soc Nephrol. page： Epub ahead of print 2015.9

*Pancreatic Neuroendocrine Tumors in Mice Deficient in Proglucagon-Derived Peptides.

Takano Y, Kasai K, Takagishi Y, Kikumori T, Imai T, Murata Y, Hayashi Y.

PLoS ONE Vol. 10 ( 7 ) page： e0133812 2015.7

グルカゴンの真の特異的作用は何か？グルカゴン作用欠損モデルの表現型.

林　良敬

実験医学 Vol. 33 ( 6 ) page： 897-902 2015.4

Low temperature-induced circulating triiodothyronine accelerates seasonal testicular regression.

K. Ikegami, Y. Atsumi, E. Yonenaga, H. Ono, I. Murayama, Y. Nakane, W. Ota, N. Arai, A. Tega, M. Iigo, V. M. Darras, K. Tsutsui, Y. Hayashi, S. Yoshida, Y. Yoshimura

Endocrinology Vol. 156 ( 2 ) page： 647-659 2015.2

Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion.

Shibue K, Yamane S, Harada N, Hamasaki A, Suzuki K, Joo E, Iwasaki K, Nasteska D, Harada T, Hayashi Y, Adachi Y, Owada Y, Takayanagi R, Inagaki N.

Am J Physiol Endocrinol Metab. Vol. 308 ( 7 ) page： E583-E591 2015.1

Activation of the RhoB signaling pathway by thyroid hormone receptor ß in thyroid cancer cells.

Ichijo S, Furuya F, Shimura H, Hayashi Y, Takahashi K, Ohta K, Kobayashi T, Kitamura K.

PLoS One Vol. 9 ( 12 ) page： e116252 2014.12

Glucagon is essential for adaptive thermongenesis in brown adipose tissue Reviewed

K. Kinoshita, N. Ozaki, Y. Takagi, Y. Murata, Y. Oshida, Y. Hayashi

Endocrinology Vol. 155 ( 9 ) page： 3484-3492 2014.6

KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state. Reviewed

H. Ogata, Y. Seino, N. Harada, A. Iida, K. Suzuki, T. Izumoto, K. Ishikawa, E. Uenishi, N. Ozaki, Y. Hayashi, T. Miki, N. Inagaki, S. Tsunekawa, Y. Hamada, S. Seino, Y. Oiso

Journal of ENdocrinology Vol. 222 ( 2 ) page： 191-200 2014.6

Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice.

Okawa T, Kamiya H, Himeno T, Seino Y, Tsunekawa S, Hayashi Y, Harada N, Yamada Y, Inagaki N, Seino Y, Oiso Y, Nakamura J.

J Diabetes Investig Vol. 5 ( 1 ) page： 31-37 2013.10

Hyperthyroidism due to thyroid-stimulating hormone secretion after surgery for Cushing's syndrome: a novel cause of the syndrome of inappropriate secretion of thyroid-stimulating hormone. Reviewed

D. Tamada, T. Onodera, T. Kitamura, Y. Yamamoto, Y. Hayashi, Y. Murata, M. Otsuki, I. Shimomura

J Clin Endocrinol Metab Vol. 98 ( 7 ) page： 2656-2662 2013.5

S. Xu, Y. Hayashi, Y. Takagishi, M. Itoh, Y. Murata

PLoS One Vol. 8 ( 5 ) page： e64415 2013.5

Ectopic expression of GIP in pancreatic ß-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides. Reviewed

A. Fukami, Y. Seino, N. Ozaki, M. Yamamoto, C. Sugiyama, E. Sakamoto-Miura, T. Himeno, Y. Takagishi, S. Tsunekawa, S. Ali, D. J. Drucker, Y. Murata, Y. Seino, Y. Oiso, Y. Hayashi

Diabetes page： doi: 10.2337/db12-0294 2012.10

グルカゴンによる代謝制御 Invited

林　良敬

糖尿病と代謝 Vol. 40 ( 3 ) page： 1-8 2012.9

Fertility and pregnancy-associated ß-cell proliferation in mice deficient in proglucagon-derived peptides. Reviewed

C. Sugiyama, M. Yamamoto, T. Kotani, F. Kikkawa, Y. Murata, Y. Hayashi

Plos One 2012.8

Isolated growth hormone deficiency in two siblings because of paternal mosaicism for a mutation in the GH1 gene. Reviewed

M. Tsubahara, Y. Hayashi, S. Niijima, M. Yamamoto, T. Kamijo, Y. Murata, H. Haruna, A. Okumura, T. Shimizu

Clin Endocrinol (Oxf.) Vol. 76 ( 3 ) page： 420-424 2012.3

Aberrant promoter methylation in overexpression of CITED1 in papillary thyroid cancer. Reviewed

M. Sassa, Y. Hayashi, R. Watanabe, T. Kikumori, T. Imai, J. Kurebayashi, T. Kiuchi, Y. Murata

Thyroid Vol. 21 ( 5 ) page： 511-517 2011.5

A novel Caspr mutation causes the shambling mouse phenotype by disrupting axo-glial interactions of myelinated nerves. Reviewed

X.Y. Sun, Y. Takagishi, E. Okabe, Y. Chishima, Y. Kanou, S. Murase, K. Mizumura, M. Inaba, Y. Komatsu, Y. Hayashi, E. Peles, S. Oda, Y. Murata

J Neuropathol Exp Neurol Vol. 68 ( 11 ) page： 1207-1218 2009.11

Possible involvement of BRAFV600E in altered gene expression in papillary thyroid cancer. Invited Reviewed

R. Watanabe, Y. Hayashi, M. Sassa, T. Kikumori, T. Imai, T. Kiuchih, Y. Murata

Endocr J Vol. 56 page： 407-414 2009.6

Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Reviewed

Y. Sugimura, T. Murase, K. Oyama, A. Uchida, N. Sato, S. Hayasaka, Y. Kano, Y. Takagishi, Y. Hayashi, Y. Oiso, Y. Murata

Diabetologia Vol. 56 page： 962-971 2009.5

Oculocutaneous Albinism in Suncus murinus: Establishment of a Strain and Identification of its Responsible Gene. Reviewed

K. Tsuboi, Y. Hayashi, T. Jogahara, G. Ogura, Y. Murata,S. Oda

Exp Anim Vol. 58 ( 1 ) page： 31-40 2009.1

Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains. Reviewed

Ido H, Ito S, Taniguchi Y, Hayashi M, Sato-Nishiuchi R, Sanzen N, Hayashi Y, Futaki S, Sekiguchi K

J Biol Chem Vol. 283 ( 42 ) page： 28149-28157 2008.10

Identification of genes differentially expressed in mouse fetuses from streptozotocin-induced diabetic pregnancy by cDNA subtraction. Reviewed

Sato N, Sugimura Y, Hayashi Y, Murase T, Kanou Y, Kikkawa F, Murata Y

Endocr J Vol. 55 ( 2 ) page： 317-323 2008.5

Insertion of an intracisternal A particle retrotransposon element in plasma membrane calcium ATPase 2 gene attenuates its expression and produces an ataxic phenotype in joggle mutant mice. Reviewed

Sun XY, Chen ZY, Hayashi Y, Kanou Y, Takagishi Y, Oda S, Murata Y

Gene Vol. 411 ( 1-2 ) page： 94-102 2008.3

Long-term amiodarone treatment causes cardioselective hypothyroid-like alteration in gene expression profile. Reviewed

R.Q. Shi, J. K. Lee, Y. Hayashi, Y. Takeuchi, F. Kambe, S. Futaki, H. Seo, Y. Murata, I. Kodama

Eur J Parmacol Vol. 578 page： 270-278 2008

Mapping of jog locus to the region between D6Mit104 and D6Mit336 on mouse chromosome 6. Reviewed

Sun XY, Chen ZY, Kanou Y, Hayashi Y, Ohno T, Murata Y, Oda S

Vol. 56 ( 5 ) page： 389-392 2007.10

A case with isolated growth hormone deficiency caused by compound heterozygous mutations in GH-1: a novel missense mutation in the initiation codon and a 7.6kb deletion Reviewed

Hayashi Y, Kamijo T, Yamamoto M, Murata Y, Phillips JA 3rd, Ogawa M, Seo H.

Growth Horm IGF Res Vol. 17 ( 36 ) page： 249-253 2007.6

Molecular cloning of prostaglandin EP3 receptors from canine sensory ganglia and their facilitatory action on bradykinin-induced mobilization of intracellular calcium Reviewed

Kozaki Y, Kambe F, Hayashi Y, Ohmori S, Seo H, Kumazawa T, Mizumura K

J Neurochem Vol. 100 ( 6 ) page： 1636-1647 2007.3

Regulation of mesodermal differentiation of mouse embryonic stem cells by basement membranes. Reviewed

Fujiwara H, Hayashi Y, Sanzen N, Kobayashi R, Weber CN, Emoto T, Futaki S, Niwa H, Murray P, Edgar D, Sekiguchi K.

J Biol Chem Vol. 282 page： 29701-29711 2007

The Sp family of transcription factors regulates the human laminin alpha1 gene in JAR choriocarcinoma cells. Reviewed

Niimi T, Hayashi Y, Sekiguchi K, Kitagawa Y.

Biochim Biophys Acta Vol. 2006 ( 11-12 ) page： 573-579 2006.11

A novel large-scale production system for modified basement membrane matrices using gene-swapped parietal endoderm cells. Reviewed

Hayashi Y, Weber CN, Emoto T, Fujiwara H, Sanzen N, Futaki S, Sekiguchi K.

Matrix Biol Vol. 25 ( 2 ) page： 85-88 2006.3

Activation of the RhoB signaling pathway by thyroid hormone receptor ß in thyroid cancer cells. Reviewed

S. Ichijo, F. Furuya, H. Shimura, Y. Hayashi, K. Takahashi, K. Ohta, T. Kobayashi, K. Kitamura.

PLoS ONE Vol. 9 ( 12 ) page： e116252 2005.12

Growth hormone releasing hormone receptor (GHRH-r) gene mutation in Indian children with familial isolated growth hormone deficiency: a study from western India Reviewed

Desai MP, Upadhye PS, Kamijo T, Yamamoto M, Ogawa M, Hayashi Y, Seo H, Nair SR.

J Pediatr Endocrinol Metab Vol. 18 ( 10 ) page： 1955-973 2005.10

The transcriptional landscape of the mammalian genome. Reviewed

Carninci P et al FANTOM Consortium; RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group).

Science Vol. 309 page： 1559-1563 2005.9

Sox7 Plays Crucial Roles in Parietal Endoderm Differentiation in F9 Embryonal Carcinoma Cells through Regulating Gata-4 and Gata-6 Expression. Reviewed

S. Futaki, Y. Hayashi, T. Emoto, C.N. Weber, K. SekiguchiS. Futaki, Y. Hayashi, T. Emoto, C.N. Weber, K. Sekiguchi

Mol Cell Biol Vol. 24 ( 12 ) page： 10495-10503 2004.12

A nonsense mutation (E72X) in growth hormone releasing hormone receptor (GHRHR) gene is the major cause of familial isolated growth hormone deficiency in Western region of India: founder effect suggested by analysis of dinucleotide repeat polymorphism close to GHRHR gene Reviewed

Kamijo, T. Hayashi, Y. Seo, H. Yamamoto, M. Ogawa, M. Choski, C. S. Sawant, N. J. Colaco, M. P. Desai, M. P.

Growth Horm IGF Res Vol. 14 ( 5 ) page： 394-401 2004.10

SOX7 and SOX17 Regulate the Parietal Endoderm-specific Enhancer Activity of Mouse Laminin {alpha}1 Gene Reviewed

Niimi, T. Hayashi, Y. Futaki, S. Sekiguchi, K.

J Biol Chem Vol. 279 ( 36 ) page： 38055-38061 2004.9

Establishment and characterization of a parietal endoderm-like cell line derived from Engelbreth-Holm-Swarm tumor (EHSPEL), a possible resource for an engineered basement membrane matrix Reviewed

Hayashi, Y. Emoto, T. Futaki, S. Sekiguchi, K.

Matrix Biol Vol. 23 ( 1 ) page： 47-62 2004.4

Molecular dissection of the alpha -dystroglycan- and integrin-binding sites within the globular domain of human laminin-10 Reviewed

Ido, H. Harada, K. Futaki, S. Hayashi, Y. Nishiuchi, R. Natsuka, Y. Li, S. Wada, Y. Combs, A. C. Ervasti, J. M. Sekiguchi, K.

J Biol Chem Vol. 279 ( 12 ) page： 10946-10954 2004.3

Molecular basis of constitutive production of basement membrane components: Gene expression profiles of engelbreth-holm-swarm tumor and F9 embryonal carcinoma cells Reviewed

Futaki, S. Hayashi, Y. Yamashita, M. Yagi, K. Bono, H. Hayashizaki, Y. Okazaki, Y. Sekiguchi, K.

J Biol Chem Vol. 278 ( 50 ) page： 50691-50701 2003

A role for thyroid hormone transporters in transcriptional regulation by thyroid hormone receptors Reviewed

Ritchie, J. W. Shi, Y. B. Hayashi, Y. Baird, F. E. Muchekehu, R. W. Christie, G. R. Taylor, P. M.

Mol Endocrinol Vol. 17 ( 4 ) page： 653-661 2003

Identification of an upstream enhancer in the mouse laminin alpha 1 gene defining its high level of expression in parietal endoderm cells Reviewed

Niimi, T. Hayashi, Y. Sekiguchi, K.

J Biol Chem Vol. 278 ( 11 ) page： 9332-9338 2003

Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T(3)-regulated transcription of genes in vivo Reviewed

Takeuchi, Y. Murata, Y. Sadow, P. Hayashi, Y. Seo, H. Xu, J. O'Malley, B. W. Weiss, R. E. Refetoff, S.

Endocrinology Vol. 143 ( 4 ) page： 1346-1352 2002

Type 1 iodothyronine deiodinase in the house musk shrew (Suncus murinus, Insectivora: Soricidae): cloning and characterization of complementary DNA, unique tissue distribution and regulation by T(3) Reviewed

Rogatcheva, M. Hayashi, Y. Oda, S. Seo, H. Cua, K. Refetoff, S. Murakami, M. Mori, M. Murata, Y.

Gen Comp Endocrinol Vol. 127 ( 1 ) page： 48-58 2002

Identification and recombinant production of human laminin alpha4 subunit splice variants Reviewed

Hayashi, Y. Kim, K. H. Fujiwara, H. Shimono, C. Yamashita, M. Sanzen, N. Futaki, S. Sekiguchi, K.

Biochem Biophys Res Commun Vol. 299 ( 3 ) page： 498-504 2002

Familial isolated growth hormone deficiency: genetics and pathophysiology Invited Reviewed

Hayashi, Y. Kamijo, T. Ogawa, M. Seo, H.

Endocr J Vol. 49 ( 3 ) page： 265-272 2002

Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha Reviewed

Macchia, P. E. Takeuchi, Y. Kawai, T. Cua, K. Gauthier, K. Chassande, O. Seo, H. Hayashi, Y. Samarut, J. Murata, Y. Weiss, R. E. Refetoff, S.

Proc Natl Acad Sci U S A Vol. 98 ( 1 ) page： 349-354 2001

Somatic gene alteration of AIB1 gene in patients with breast cancer Reviewed

Shibata, A. Hayashi, Y. Imai, T. Funahashi, H. Nakao, A. Seo, H.

Endocr J Vol. 48 ( 2 ) page： 199-204 2001

Involvement of AP-1 and steroidogenic factor (SF)-1 in the cAMP-dependent induction of human adrenocorticotropic hormone receptor (ACTHR) promoter Reviewed

Sarkar, D. Kambe, F. Hayashi, Y. Ohmori, S. Funahashi, H. Seo, H.

Endocr J Vol. 47 ( 1 ) page： 63-75 2000

Identification of a novel myosin-Va mutation in an ataxic mutant rat, dilute-opisthotonus Reviewed

Futaki, S. Takagishi, Y. Hayashi, Y. Ohmori, S. Kanou, Y. Inouye, M. Oda, S. Seo, H. Iwaikawa, Y. Murata, Y.

Mamm Genome Vol. 11 ( 8 ) page： 649-655 2000

Responsiveness to thyroid hormone is enhanced in rat hepatocytes cultured as spheroids compared with that in monolayers: altered responsiveness to thyroid hormone possibly involves complex formed on thyroid hormone response elements Reviewed

Menjo, M. Yamaguchi, S. Murata, Y. Hayashi, Y. Nagaya, T. Ohmori, S. Refetoff, S. Seo, H.

Thyroid Vol. 9 ( 9 ) page： 959-967 1999

Glucocorticoids increase retinoid-X receptor alpha (RXRalpha) expression and enhance thyroid hormone action in primary cultured rat hepatocytes Reviewed

Yamaguchi, S. Murata, Y. Nagaya, T. Hayashi, Y. Ohmori, S. Nimura, Y. Seo, H.

J Mol Endocrinol Vol. 22 ( 1 ) page： 81-90 1999

A Japanese family with autosomal dominant growth hormone deficiency Reviewed

Saitoh, H. Fukushima, T. Kamoda, T. Tanae, A. Kamijo, T. Yamamoto, M. Ogawa, M. Hayashi, Y. Ohmori, S. Seo, H.

Eur J Pediatr Vol. 158 ( 8 ) page： 624-627 1999

9-cis-retinoic acid decreases the level of its cognate receptor, retinoid X receptor, through acceleration of the turnover Reviewed

Nomura, Y. Nagaya, T. Hayashi, Y. Kambe, F. Seo, H.

Biochem Biophys Res Commun Vol. 260 ( 3 ) page： 729-733 1999

A novel mutation at the donor splice site of intron 3 of the GH-I gene in a patient with isolated growth hormone deficiency Reviewed

Hayashi, Y. Kamijo, T. Yamamoto, M. Ohmori, S. Phillips, J. A., 3rd Ogawa, M. Igarashi, Y. Seo, H.

Growth Horm IGF Res Vol. 9 ( 6 ) page： 434-437 1999

Mutations in intron 3 of GH-1 gene associated with isolated GH deficiency type II in three Japanese families Reviewed

Kamijo, T. Hayashi, Y. Shimatsu, A. Kinoshita, E. Yoshimoto, M. Ogawa, M. Seo, H.

Clin Endocrinol (Oxf) Vol. 51 ( 3 ) page： 355-360 1999

Hereditary isolated growth hormone deficiency caused by GH1 gene mutations in Japanese patients

Kamijo, T. Hayashi, Y. Seo, H. Ogawa, M.

Growth Horm IGF Res Vol. 9 ( suppl B ) page： 31-34 1999

Inhibition of growth hormone (GH) secretion by a mutant GH-I gene product in neuroendocrine cells containing secretory granules: an implication for isolated GH deficiency inherited in an autosomal dominant manner Reviewed

Hayashi, Y. Yamamoto, M. Ohmori, S. Kamijo, T. Ogawa, M. Seo, H.

J Clin Endocrinol Metab Vol. 84 ( 6 ) page： 2134-2139 1999

Polymorphism of homopolymeric glutamines in coactivators for nuclear hormone receptors Reviewed

Hayashi, Y. Yamamoto, M. Ohmori, S. Kikumori, T. Imai, T. Funahashi, H. Seo, H.

Endocr J Vol. 46 ( 2 ) page： 279-284 1999

Selective pituitary resistance to thyroid hormone produced by expression of a mutant thyroid hormone receptor beta gene in the pituitary gland of transgenic mice Reviewed

Hayashi, Y. Xie, J. Weiss, R. E. Pohlenz, J. Refetoff, S.

Biochem Biophys Res Commun Vol. 245 ( 1 ) page： 204-10 1998

Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor beta-deficient mice Reviewed

Weiss, R. E. Murata, Y. Cua, K. Hayashi, Y. Seo, H. Refetoff, S.

Endocrinology Vol. 139 ( 12 ) page： 4945-4952 1998

Molecular cloning of sucrase-isomaltase cDNA in the house musk shrew Suncus murinus and identification of a mutation responsible for isolated sucrase deficiency Reviewed

Ito, T. Hayashi, Y. Ohmori, S. Oda, S. Seo, H.

J Biol Chem Vol. 273 ( 26 ) page： 16464-16469 1998

Tumor suppressor p53 is a negative regulator in thyroid hormone receptor signaling pathways Reviewed

Bhat, M. K. Yu, C. Yap, N. Zhan, Q. Hayashi, Y. Seth, P. Cheng, S.

J Biol Chem Vol. 272 ( 46 ) page： 28989-28983 1997

Resistance to thyroid hormone caused by two mutant thyroid hormone receptors beta, R243Q and R243W, with marked impairment of function that cannot be explained by altered in vitro 3,5,3'-triiodothyroinine binding affinity Reviewed

Yagi, H. Pohlenz, J. Hayashi, Y. Sakurai, A. Refetoff, S.

J Clin Endocrinol Metab Vol. 82 ( 5 ) page： 1608-1614 1997

A splicing variant of Steroid Receptor Coactivator-1 (SRC-1E): the major isoform of SRC-1 to mediate thyroid hormone action Reviewed

Hayashi, Y. Ohmori, S. Ito, T. Seo, H.

Biochem Biophys Res Commun Vol. 236 ( 1 ) page： 83-87 1997

Modification of thyroid hormone and 9-cis retinoic acid signaling by overexpression of their cognate receptors using adenoviral vector Reviewed

Hayashi, Y. Yamaguchi, S. Pohlenz, J. Murata, Y. Refetoff, S. Seo, H.

Mol Cell Endocrinol Vol. 131 ( 1 ) page： 59-66 1997

A mouse model of resistance to thyroid hormone produced by somatic gene transfer of a mutant thyroid hormone receptor Reviewed

Hayashi, Y. Mangoura, D. Refetoff, S.

Mol Endocrinol Vol. 10 ( 1 ) page： 100-106 1996

Dominant inheritance of resistance to thyroid hormone not linked to defects in the thyroid hormone receptor alpha or beta genes may be due to a defective cofactor Reviewed

Weiss, R. E. Hayashi, Y. Nagaya, T. Petty, K. J. Murata, Y. Tunca, H. Seo, H. Refetoff, S.

J Clin Endocrinol Metab Vol. 81 ( 12 ) page： 4196-4203 1996

Resistance to thyrotropin and other abnormalities of the thyrotropin receptor

Refetoff, S. Sunthornthepvarakul, T. Gottschalk, M. E. Hayashi, Y.

Recent Prog Horm Res Vol. 51 page： 97-120 1996

Thyroxine-binding globulin: organization of the gene and variants Reviewed

Refetoff, S. Murata, Y. Mori, Y. Janssen, O. E. Takeda, K. Hayashi, Y.

Horm Res Vol. 45 ( 3-5 ) page： 128-138 1996

Expression of thyroid peroxidase in EBV-transformed B cell lines using adenovirus Reviewed

Hidaka, Y. Hayashi, Y. Fisfalen, M. E. Suzuki, S. Takeda, T. Refetoff, S. DeGroot, L. J.

Thyroid Vol. 6 ( 1 ) page： 23-28 1996

Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase Reviewed

Eggerickx, D. Denef, J. F. Labbe, O. Hayashi, Y. Refetoff, S. Vassart, G. Parmentier, M. Libert, F.

Biochem J Vol. 309 ( 3 ) page： 837-843 1995

Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants Reviewed

Yen, P. M. Wilcox, E. C. Hayashi, Y. Refetoff, S. Chin, W. W.

Endocrinology Vol. 136 ( 7 ) page： 2845-2851 1995

Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene Reviewed

Sunthornthepvarakul, T. Gottschalk, M. E. Hayashi, Y. Refetoff, S.

N Engl J Med Vol. 332 ( 3 ) page： 155-160 1995

Expression of human thyrotropin receptor by recombinant adenovirus Reviewed

Okamoto, Y. Hayashi, Y. DeGroot, L. J.

Thyroid Vol. 5 ( 1 ) page： 51-53 1995

Do clinical manifestations of resistance to thyroid hormone correlate with the functional alteration of the corresponding mutant thyroid hormone-beta receptors? Reviewed

Hayashi, Y. Weiss, R. E. Sarne, D. H. Yen, P. M. Sunthornthepvarakul, T. Marcocci, C. Chin, W. W. Refetoff, S.

J Clin Endocrinol Metab Vol. 80 ( 11 ) page： 3246-3256 1995

Expression of a thyroid hormone-responsive recombinant gene introduced into adult mice livers by replication-defective adenovirus can be regulated by endogenous thyroid hormone receptor Reviewed

Hayashi, Y. DePaoli, A. M. Burant, C. F. Refetoff, S.

J Biol Chem Vol. 269 ( 39 ) page： 23872-23875 1994

A new point mutation (C446R) in the thyroid hormone receptor-beta gene of a family with resistance to thyroid hormone Reviewed

Weiss, R. E. Chyna, B. Duell, P. B. Hayashi, Y. Sunthornthepvarakul, T. Refetoff, S.

J Clin Endocrinol Metab Vol. 78 ( 5 ) page： 1253-1256 1994

Polymorphism of a variant human thyrotropin receptor (hTSHR) gene Reviewed

Sunthornthepvarakul, T. Hayashi, Y. Refetoff, S.

Thyroid Vol. 4 ( 2 ) page： 147-149 1994

An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families Reviewed

Sunthornthepvarakul, T. Angkeow, P. Weiss, R. E. Hayashi, Y. Refetoff, S.

Biochem Biophys Res Commun Vol. 202 ( 2 ) page： 781-787 1994

Resistance to thyroid hormone in subjects from two unrelated families is associated with a point mutation in the thyroid hormone receptor beta gene resulting in the replacement of the normal proline 453 with serine Reviewed

Refetoff, S. Weiss, R. E. Wing, J. R. Sarne, D. Chyna, B. Hayashi, Y.

Thyroid Vol. 4 ( 3 ) page： 249-254 1994

Mutations of CpG dinucleotides located in the triiodothyronine (T3)-binding domain of the thyroid hormone receptor (TR) beta gene that appears to be devoid of natural mutations may not be detected because they are unlikely to produce the clinical phenotype of resistance to thyroid hormone Reviewed

Hayashi, Y. Sunthornthepvarakul, T. Refetoff, S.

J Clin Invest Vol. 94 ( 2 ) page： 607-615 1994

Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation Reviewed

Hayashi, Y. Mori, Y. Janssen, O. E. Sunthornthepvarakul, T. Weiss, R. E. Takeda, K. Weinberg, M. Seo, H. Bell, G. I. Refetoff, S.

Mol Endocrinol Vol. 7 ( 8 ) page： 1049-1060 1993

The relative expression of mutant and normal thyroid hormone receptor genes in patients with generalized resistance to thyroid hormone determined by estimation of their specific messenger ribonucleic acid products Reviewed

Hayashi, Y. Janssen, O. E. Weiss, R. E. Murata, Y. Seo, H. Refetoff, S.

J Clin Endocrinol Metab Vol. 76 ( 1 ) page： 64-69 1993

Modification of water and electrolyte metabolism during head-down tilting by hypoglycemia in men Reviewed

Hayashi, Y. Murata, Y. Seo, H. Miyamoto, N. Kambe, F. Ohmori, S. Yamamoto, C. Hayamizu, S. Tamura, Y. Matsui, N.

J Appl Physiol Vol. 73 ( 5 ) page： 1785-1790 1992

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