Faculty Profiles - HAYASHI, Yoshitaka

Papers - HAYASHI, Yoshitaka

Division display 1 - 20 of about 109 ／ All the affair displays >>

Glutaminostatin: Another facet of glucagon as a regulator of plasma amino acid concentrations Reviewed

Hayashi Yoshitaka

JOURNAL OF DIABETES INVESTIGATION Vol. 10 ( 6 ) page： 1391 - 1393 2019.11

*Remodeling of Hepatic Metabolism and Hyperaminoacidemia in Mice Deficient in Proglucagon-derived Peptides. Reviewed

C. Watanabe, Y. Seino, H. Miyahira, M. Yamamoto, A. Fukami, N. Ozaki, Y. Takagishi, J. Sato, T. Fukuwatari, K. Shibata, Y. Oiso, Y. Murata, Y. Hayashi

Diabetes Vol. 61 ( 1 ) page： 74-84 2012.1

*Metabolic impact of glucagon deficiency. Invited Reviewed

Yoshitaka Hayashi

Diabetes, Obesity and Metabolism. Vol. 13 ( suppl 1 ) page： 151-157 2011.10

*Mice Deficient for Glucagon Gene-Derived Peptides Display Normoglycemia, and Hyperplasia of Islet a-Cells but not of Intestinal L-cells. Reviewed

Y. Hayashi, M. Yamamoto, H. Mizoguchi, C. Watanabe, R. Ito, S. Yamamoto, X.Y. Sun, Y. Murata

Mol Endocrinol Vol. 23 ( 12 ) page： 1990-1999 2009.12

Voltage-gated calcium channel α<sub>2</sub>δ-1 subunit is involved in the regulation of glucose-stimulated GLP-1 secretion in mice Reviewed Open Access

Yang, YH; Yamane, S; Harada, N; Ikeguchi-Ogura, E; Yamamoto, K; Wada, N; Fauzi, M; Murakami, T; Yabe, D; Hayashi, Y; Inagaki, N

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY Vol. 328 ( 3 ) page： G243 - G251 2025.3

Superoxide dismutase 2 deficiency in mesenchymal stromal cells induces sympathetic denervation and functional impairment of brown adipose tissue Reviewed Open Access

Urano, Y; Mii, S; Asai, S; Esaki, N; Ando, R; Shiraki, Y; Iida, T; Kato, K; Hori, M; Hayashi, Y; Shimizu, T; Enomoto, A

PATHOLOGY INTERNATIONAL Vol. 75 ( 2 ) page： 69 - 81 2025.2

Advances in basic research on glucagon and alpha cells Reviewed

Hayashi, Y

DIABETOLOGY INTERNATIONAL Vol. 15 ( 3 ) page： 348 - 352 2024.7

Impaired Fat Absorption from Intestinal Tract in High-Fat Diet Fed Male Mice Deficient in Proglucagon-Derived Peptides Reviewed

Nishida, K; Ueno, S; Seino, Y; Hidaka, S; Murao, N; Asano, Y; Fujisawa, H; Shibata, M; Takayanagi, T; Ohbayashi, K; Iwasaki, Y; Iizuka, K; Okuda, S; Tanaka, M; Fujii, T; Tochio, T; Yabe, D; Yamada, Y; Sugimura, Y; Hirooka, Y; Hayashi, Y; Suzuki, A

NUTRIENTS Vol. 16 ( 14 ) 2024.7

Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon-derived peptides Reviewed

Ueno, S; Seino, Y; Hidaka, S; Nakatani, M; Hitachi, K; Murao, N; Maeda, Y; Fujisawa, H; Shibata, M; Takayanagi, T; Iizuka, K; Yabe, D; Sugimura, Y; Tsuchida, K; Hayashi, Y; Suzuki, A

JOURNAL OF DIABETES INVESTIGATION Vol. 14 ( 9 ) page： 1045 - 1055 2023.9

A newly developed glucagon sandwich ELISA is useful for more accurate glucagon evaluation than the currently used sandwich ELISA in subjects with elevated plasma proglucagon-derived peptide levels Reviewed

Kobayashi, M; Maruyama, N; Yamamoto, Y; Togawa, T; Ida, T; Yoshida, M; Miyazato, M; Kitada, M; Hayashi, Y; Kashiwagi, A; Kitamura, T

JOURNAL OF DIABETES INVESTIGATION Vol. 14 ( 5 ) page： 648 - 658 2023.5

An analysis of intestinal morphology and incretin-producing cells using tissue optical clearing and 3-D imaging Reviewed

Hatoko, T; Harada, N; Tokumoto, S; Yamane, S; Ikeguchi-Ogura, E; Kato, T; Yasuda, T; Tatsuoka, H; Shimazu-Kuwahara, S; Yabe, D; Hayashi, Y; Inagaki, N

SCIENTIFIC REPORTS Vol. 12 ( 1 ) page： 17530 2022.10

High Protein Diet Feeding Aggravates Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides Reviewed

Ueno, S; Seino, Y; Hidaka, S; Maekawa, R; Takano, Y; Yamamoto, M; Hori, M; Yokota, K; Masuda, A; Himeno, T; Tsunekawa, S; Kamiya, H; Nakamura, J; Kuwata, H; Fujisawa, H; Shibata, M; Takayanagi, T; Sugimura, Y; Yabe, D; Hayashi, Y; Suzuki, A

NUTRIENTS Vol. 14 ( 5 ) 2022.3

Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids Reviewed

Fujiwara Yuta, Yamane Shunsuke, Harada Norio, Ikeguchi-Ogura Eri, Usui Ryota, Nakamura Toshihiro, Iwasaki Kanako, Suzuki Kazuyo, Yabe Daisuke, Hayashi Yoshitaka, Inagaki Nobuya

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY Vol. 320 ( 4 ) page： G617 - G626 2021.4

Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in -cell Mass Independent of Body Weight Gain in Mice Reviewed

Masuda Atsushi, Seino Yusuke, Murase Masatoshi, Hidaka Shihomi, Shibata Megumi, Takayanagi Takeshi, Sugimura Yoshihisa, Hayashi Yoshitaka, Suzuki Atsushi

NUTRIENTS Vol. 11 ( 5 ) 2019.5

Acute Cholesterol-Lowering Effect of Exendin-4 in Ldlr(-/-) and C57BL/6J Mice. Reviewed

Hori M, Hasegawa Y, Hayashi Y, Nakagami T, Harada-Shiba M

Journal of atherosclerosis and thrombosis 2022.3

Carbohydrate-induced weight gain models for diabetes research: contribution of incretins and parasympathetic signal. Reviewed

Seino Y, Murase M, Hayashi Y, Suzuki A

Journal of diabetes investigation Vol. 12 ( 1 ) page： 3 - 5 2021.1

Glucagon regulates lipolysis and fatty acid oxidation through inositol triphosphate receptor 1 in the liver Reviewed

Hayashi Yoshitaka

JOURNAL OF DIABETES INVESTIGATION Vol. 12 ( 1 ) page： 32 - 34 2021.1

Deficiency of glucagon gene-derived peptides induces peripheral polyneuropathy in mice Reviewed

Motegi Mikio, Himeno Tatsuhito, Nakai-Shimoda Hiromi, Inoue Rieko, Ozeki Norio, Hayashi Yusuke, Sasajima Sachiko, Mohiuddin Mohammad Sarif, Asano-Hayami Emi, Kato Makoto, Asano Saeko, Miura-Yura Emiri, Morishita Yoshiaki, Kondo Masaki, Tsunekawa Shin, Kato Yoshiro, Kato Koichi, Naruse Keiko, Seino Yusuke, Hayashi Yoshitaka, Nakamura Jiro, Kamiya Hideki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 532 ( 1 ) page： 47 - 53 2020.10

Sphingosine kinase 1–interacting protein is a dual regulator of insulin and incretin secretion Reviewed

Yanyan Liu, Shin Ichi Harashima, Yu Wang, Kazuyo Suzuki, Shinsuke Tokumoto, Ryota Usui, Hisato Tatsuoka, Daisuke Tanaka, Daisuke Yabe, Norio Harada, Yoshitaka Hayashi, Nobuya Inagaki

FASEB Journal Vol. 33 ( 5 ) page： 6239 - 6253 2019.5

Language：Japanese Publishing type：Research paper (scientific journal)

© FASEB Our previous study demonstrated that sphingosine kinase 1–interacting protein (SKIP, or Sphkap) is expressed in pancreatic β-cells, and depletion of SKIP enhances glucose-stimulated insulin secretion. We find here that SKIP is also expressed in intestinal K- and L-cells and that secretion of gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) as well as insulin are significantly increased, and blood glucose levels are decreased in SKIP-deficient (SKIP−/−) mice compared with those in wild-type mice. Plasma triglyceride (Tg), LDL cholesterol, and mRNA levels of proinflammatory cytokines in adipose tissues, livers, and intestines were found to be significantly decreased in SKIP−/− mice. The phenotypic characteristics of SKIP−/− mice, including adiposity and attenuation of basal inflammation, were abolished by genetic depletion of GIP. The improvement of glucose tolerance and lipid profiles in SKIP−/− mice were cancelled by GLP-1 receptor antagonist exendin-(9–39) treatment. In summary, depletion of SKIP ameliorates glucose tolerance by enhancing secretion of insulin and incretins, improves lipid metabolism, and reduces basal inflammation levels. Thus, inhibition of SKIP action may emerge as a new option for treatment of type 2 diabetes mellitus with metabolic dysfunction.—Liu, Y., Harashima, S., Wang, Y., Suzuki, K., Tokumoto, S., Usui, R., Tatsuoka, H., Tanaka, D., Yabe, D., Harada, N., Hayashi, Y., Inagaki, N. Sphingosine kinase 1–interacting protein is a dual regulator of insulin and incretin secretion. FASEB J. 33, 6239–6253 (2019). www.fasebj.org.

DOI： 10.1096/fj.201801783RR

Web of Science

Scopus

PubMed

Two Mutations in Thyroid Hormone Receptor Beta Gene (P453A and C36Y) in a Family with Resistance to Thyroid Hormone with Comorbid Myotonic Dystrophy. Reviewed

Takeda K, Nemoto KI, Hayashi Y, Yamamoto M, Sakuta R, Kimura T, Noto H

Thyroid : official journal of the American Thyroid Association Vol. 29 ( 4 ) page： 607 - 608 2019.4

　 PREV - NEXT 　

<HAYASHI, Yoshitaka>

Papers - HAYASHI, Yoshitaka