Faculty Profiles - OKAJIMA, Tetsuya

Papers - OKAJIMA, Tetsuya

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Glycoconjugate glycosyltransferases Invited Reviewed

Furukawa K, Tsuchida A, Okajima T, Furukawa K

Glycoconj. J Vol. 26 page： 987-98 2008

Engineering of a mammalian O-glycosylation pathway in the yeast Saccharomyces cerevisiae: production of O-fucosylated epidermal growth factor domains Reviewed

Yuko Chigira, Takuji Oka, Tetsuya Okajima and Yoshifumi Jigami

Glycobiology Vol. 18 page： 303-314 2008

Biological functions of glycosyltransferase genes involved in O-fucose glycan synthesis Invited Reviewed

Okajima T, Matsuura A, Matsuda T

J. Biochem. Vol. 144 page： 1-6 2008

糖転移酵素のNotch受容体フォールディングにおける役割

松浦愛子・松田幹・岡島徹也

蛋白質核酸酵素 Vol. 53 page： 1480-1485 2008

*O-linked GlcNAc is present on the extracellular domain of Notch receptors. Reviewed

Matsuura A, Ito M, Sakaidani Y, Kondo T, Murakami K, Furukawa K, Nadano D, Matsuda T, and Okajima T

J. Biol. Chem. Vol. 283 ( 51 ) page： 35486-35495 2008

Glycosyltransferases involved in O-fucose glycan synthesis.

Okajima T, Matsuda T

Experimental Glycoscience page： 33-35 2008

Association of chicken zona pellucida glycoprotein (ZP) B1 with ZPC induces formation of ZPB1-ZPC fibrous aggregates containing disulfide-bridged ZPB1 dimer. Reviewed

Okumura H, Okajima T, Nadano D, Matsuda T.

Biochem Biophys Res Commun. Vol. 364 ( 3 ) page： 682-688 2007.12

Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. Reviewed

Miyoshi M, Okajima T, Matsuda T, Fukuda MN, Nadano D.

Biochem J Vol. 404 ( 3 ) page： 373-381 2007.6

Roles of fucosyltransferase and fucose in Notch signaling Invited

Okajima T, Matuda T.

Methods Enzymol Vol. 417 page： 116-26 2006

*Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding. Reviewed

Okajima T, Xu A, Lei L, Irvine KD.

Science Vol. 307 page： 1599-603 2005.3

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Notch proteins are receptors for a conserved signaling pathway that affects numerous cell fate decisions. We found that in Drosophila, Protein O-fucosyltransferase 1 (OFUT1), an enzyme that glycosylates epidermal growth factor-like domains of Notch, also has a distinct Notch chaperone activity. OFUT1 is an endoplasmic reticulum protein, and its localization was essential for function in vivo. OFUT1 could bind to Notch, was required for the trafficking of wild-type Notch out of the endoplasmic reticulum, and could partially rescue defects in secretion and ligand binding associated with Notch point mutations. This ability of OFUT1 to facilitate folding of Notch did not require its fucosyltransferase activity. Thus, a glycosyltransferase can bind its substrate in the endoplasmic reticulum to facilitate normal folding.

*Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe. Invited Reviewed

Okajima T, Xu A, Irvine KD.

J Biol Chem. Vol. 278 page： 42340-5 2003.10

Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. Reviewed

Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K.

J Biol Chem. Vol. 278 page： 22787-94 2003.6

XGalT-1 involved in the synthesis of glyosaminoglycans of proteoglycans and Ehlers-Danlos syndrome (progeroid type) Invited

Furukawa K, Okajima T, Nakamura Y.

Tanpakushitsu Kakusan Koso. Vol. 48 ( 8 Suppl ) page： 1152-7 2003.1

*Regulation of notch signaling by O-linked fucose. Invited Reviewed

Okajima T, Irvine KD.

Cell Vol. 111 page： 893-904 2002.12

Galactosyltransferase I is a gene responsible for progeroid variant of Ehlers-Danlos syndrome: molecular cloning and identification of mutations. Invited

Furukawa K, Okajima T.

Biochim Biophys Acta. Vol. 1573 ( 3 ) page： 377-81 2002.12

Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis. Reviewed

Nakamura Y, Haines N, Chen J, Okajima T, Furukawa K, Urano T, Stanley P, Irvine KD, Furukawa K.

J Biol Chem. Vol. 277 ( 48 ) page： 46280-8 2002.11

b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. Reviewed

Okada M, Itoh Mi M, Haraguchi M, Okajima T, Inoue M, Oishi H, Matsuda Y, Iwamoto T, Kawano T, Fukumoto S, Miyazaki H, Furukawa K, Aizawa S, Furukawa K.

J Biol Chem. Vol. 277 ( 3 ) page： 1633-6 2002.1

Expression cloning of human globoside synthase cDNAs: Identification of β3Gal-T3 as UDP-N-acetylgalactosamine: globotriaosylceramide β1,3-N-acetyl-galactosaminyltransferase. Reviewed

Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata Si, Furukawa K, Urano T, Furukawa K

J. Biol. Chem. Vol. 275 page： 40498-40503 2000

Molecular cloning and expression of mouse GD1α/GT1aα/GQ1bα synthase (ST6GalNAc VI) gene. Reviewed

Okajima T, Chen HH, Ito H, Kiso M, Tai T, Furukawa K, Urano T, Furukawa K.

J. Biol. Chem. Vol. 275 page： 6717-6723 2000

Molecular cloning of Gb3/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo-series glycosphingolipids. Reviewed

Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.

J. Biol. Chem. Vol. 275 page： 15152-15156 2000

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Papers - OKAJIMA, Tetsuya