Faculty Profiles - OKAJIMA, Tetsuya

Papers - OKAJIMA, Tetsuya

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Altered glycolipid metabolism during acute kidney injury exacerbates renal inflammation. Open Access

Osada A, Tanaka M, Sugiura Y, Yuan X, Yamashita S, Ochi K, Kohda H, Ito A, Go S, Okajima T, Kadomatsu K, Yanagita M, Furuhashi K, Maruyama S, Suganami T

Scientific reports 2025.12

Differential O- glucose elongation on a specific EGF repeat within the canonical ligand-binding domain regulates DLL1/4-NOTCH1 signaling

Tsukamoto, Y; Aoki, K; Kama, Y; Hosokawa, H; Saiki, W; Tsukamoto, N; Kato, K; Hosokawa, Y; Sato, R; Uesugi, N; Fujita, Y; Fukazawa, K; Funada, D; Suzuki, F; Kurebayashi, Y; Urata, Y; Uchiyama, S; Wang, WW; Minami, A; Takahashi, T; Tiemeyer, M; Narimatsu, Y; Okajima, T; Takeuchi, H

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 122 ( 43 ) page： e2504827122 2025.10

Retention of DLK1 in the endoplasmic reticulum identifies roles for EGF-like-domain-specific O-glycans in the secretory pathway

Tashima, Y; Tsukamoto, Y; Tsukamoto, N; Kondo, Y; Uddin, E; Furukawa, W; Go, S; Arakawa, H; Kaji, H; Takeuchi, H; Okajima, T

FEBS JOURNAL Vol. 292 ( 20 ) page： 5355 - 5381 2025.10

XXYLT1 inhibits NOTCH1 activation in Jurkat cells while promoting cell proliferation

Wang, WW; Saiki, W; Tsukamoto, Y; Uchiyama, S; Kondo, Y; Okajima, T; Takeuchi, H

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 87 ( 3 ) page： 431 - 450 2025.8

O-GlcNAc glycans in the mammalian extracellular environment

Tsukamoto, Y; Okajima, T

CARBOHYDRATE RESEARCH Vol. 549 page： 109378 2025.3

The Human Glycome Atlas project for cataloging all glycan-related omics data in human Reviewed

Aoki-Kinoshita, KF; Akune-Taylor, Y; Ando, H; Angata, K; Fujita, M; Furukawa, JI; Kaji, H; Kato, K; Kitajima, K; Kizuka, Y; Matsui, Y; Nakajima, K; Nishihara, S; Okajima, T; Sakamoto, K; Sato, C; Thaysen-Andersen, M; Togayachi, A; Yagi, H; Zappa, A; Kadomatsu, K

GLYCOBIOLOGY Vol. 34 ( 11 ) 2025.1

Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance

Hashimoto, N; Ito, S; Kudo, AY; Kawasaki, N; Hashimoto, N; Ito, S; Harazono, A; Tsuchida, A; Mouri, Y; Yamamoto, A; Okajima, T; Ohmi, Y; Furukawa, K; Kudo, Y; Kawasaki, N; Furukawa, K

ISCIENCE Vol. 27 ( 11 ) page： 111139 2024.11

Revisiting of role of Eogt, atypical O-glycan synthase, based on tissue distribution

Kondo, Y; Kawai, K; Toida, N; Okajima, T

GLYCOBIOLOGY Vol. 34 ( 11 ) page： 11 - 11 2024.11

Glycoproteomics and transport assay of ER-tethered protein Delta homolog 1 highlights the role of EGF domain-specific O-glycans in the secretory pathway

Tashima, Y; Tsukamoto, Y; Tsukamoto, N; Kondo, Y; Uddin, E; Furukawa, W; Go, S; Kaji, H; Takeuchi, H; Okajima, T

GLYCOBIOLOGY Vol. 34 ( 11 ) page： 47 - 47 2024.11

The N-acetylglucosaminyltransferase Radical fringe contributes to defects in JAG1-dependent turnover and signaling of NOTCH3 CADASIL mutants Reviewed Open Access

Suzuki, S; Mashiko, T; Tsukamoto, Y; Oya, M; Kotani, Y; Okawara, S; Matsumoto, T; Mizue, Y; Takeuchi, H; Okajima, T; Itoh, M

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 300 ( 10 ) page： 107787 2024.10

Characterization of galactosyltransferase and sialyltransferase genes mediating the elongation of the extracellular O-GlcNAc glycans Reviewed

Tsukamoto, Y; Tsukamoto, N; Saiki, W; Tashima, Y; Furukawa, JI; Kizuka, Y; Narimatsu, Y; Clausen, H; Takeuchi, H; Okajima, T

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 703 page： 149610 2024.4

Efficient Escorting Strategy for Aggregation-Prone Notch EGF Repeats with Sparcl1 Invited Reviewed

Kondo, Y; Li, YX; Okajima, T

MOLECULES Vol. 29 ( 5 ) 2024.3

Inhibitory machinery for the functional dystroglycan glycosylation Invited Reviewed Open Access

Kondo, Y; Okajima, T

JOURNAL OF BIOCHEMISTRY Vol. 173 ( 5 ) page： 333 - 335 2023.5

Evidence that only EWS among the FET proteins acquires a low partitioning property for the hyperosmotic stress response by O-GlcNAc glycosylation on its low-complexity domain Reviewed

Kakuo, M; Horii, T; Tonomura, N; Sato, R; Ogawa, M; Okajima, T; Kamemura, K

EXPERIMENTAL CELL RESEARCH Vol. 424 ( 1 ) page： 113504 2023.3

Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation Reviewed Open Access

Zhang, AL; Tsukamoto, Y; Takeuchi, H; Nishiwaki, K; Tashima, Y; Okajima, T

ANALYTICAL BIOCHEMISTRY Vol. 656 page： 114881 2022.11

Glycoproteomics of NOTCH1 EGF repeat fragments overexpressed with different glycosyltransferases in HEK293T cells reveals insights into O-GlcNAcylation of NOTCH1 Reviewed

Tsukamoto, Y; Ogawa, M; Yogi, K; Tashima, Y; Takeuchi, H; Okajima, T

GLYCOBIOLOGY Vol. 32 ( 7 ) page： 616 - 628 2022.6

Significant Roles of Notch O-Glycosylation in Cancer Invited Reviewed Open Access

Wang, WW; Okajima, T; Takeuchi, H

MOLECULES Vol. 27 ( 6 ) 2022.3

Ganglioside GD2 enhances malignant properties of melanoma by co-operating with integrin. Reviewed

Farhana, Y; Bhuiyan, RH; Ohmi, Y; Horiuchi, M; Okajima, T; Yamamoto, S; Furukawa, K; Furukawa, K

CANCER SCIENCE Vol. 113 page： 1104 - 1104 2022.2

Unique effects of expression of asialo-series ganglioside GD1alpha in human cancer cell lines Reviewed

Robiul, B; Yesmin, F; Kondo, Y; Ohkawa, Y; Ohmi, Y; Zhang, P; Okajima, T; Furukawa, K; Furukawa, K

CANCER SCIENCE Vol. 113 page： 379 - 379 2022.2

Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins Open Access

Yesmin, F; Bhuiyan, RH; Ohmi, Y; Yamamoto, S; Kaneko, K; Ohkawa, Y; Zhang, P; Hamamura, K; Cheung, NKV; Kotani, N; Honke, K; Okajima, T; Kambe, M; Tajima, O; Furukawa, K; Furukawa, K

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 23 ( 1 ) 2022.1

Eogt-catalyzed O-GlcNAcylation Invited Reviewed Open Access

Lo, PW; Okajima, T

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY Vol. 34 ( 197 ) page： E1 - E6 2022.1

Other Classes of Eukaryotic Glycans Invited Reviewed International coauthorship

Haltiwanger RS, Wells L, Freeze HH, Jafar-Nejad H, Okajima T, Stanley P, Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Mohnen D, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH

2022

St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity Reviewed Open Access

Thane, P; Ohkawa, Y; Yamamoto, S; Momota, H; Kato, A; Kaneko, K; Natsume, A; Farhana, Y; Ohmi, Y; Okajima, T; Bhuiyan, RH; Wakabayashi, T; Furukawa, K; Furukawa, K

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 83 ( 3 ) page： 535 - 549 2021.8

Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes Reviewed

Ohmi, Y; Nishikaze, T; Kitaura, Y; Ito, T; Yamamoto, S; Sugiyama, F; Matsuyama, M; Takahashi, Y; Takeda, A; Kawahara, T; Okajima, T; Furukawa, K; Furukawa, K

GLYCOBIOLOGY Vol. 31 ( 5 ) page： 557 - 570 2021.5

Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers Reviewed Open Access

Barua, R; Mizuno, K; Tashima, Y; Ogawa, M; Takeuchi, H; Taguchi, A; Okajima, T

MOLECULES Vol. 26 ( 4 ) 2021.2

Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions Invited Reviewed Open Access

Saiki, W; Ma, CY; Okajima, T; Takeuchi, H

BIOMOLECULES Vol. 11 ( 2 ) 2021.2

Roles of asialo-series ganglioside GD1α in human cancer cell lines. Reviewed

Bhuiyan, RH; Yesmin, F; Kondo, Y; Ohkawa, Y; Ohmi, Y; Zhang, P; Okajima, T; Furukawa, K; Furukawa, K

CANCER SCIENCE Vol. 112 page： 679 - 679 2021.2

Ganglioside GD2 enhances malignant properties of melanoma by co-operating with integrin. Reviewed

Yesmin, F; Bhuiyan, RH; Ohmi, Y; Okajima, T; Yamamoto, S; Furukawa, K; Furukawa, K

CANCER SCIENCE Vol. 112 page： 699 - 699 2021.2

Enzyme assay of O-GlcNAc transferase.

Nishihara S, Angata K, Aoki-Kinoshita KF, Hirabayashi J, Alam SMD, Okajima T

2021

Enzyme assay of O-fucosyltransferase 1 using Drosophila OFUT1.

Nishihara S, Angata K, Aoki-Kinoshita KF, Hirabayashi J, Okajima T

2021

3′-Sialyllactose on Notch: NOTCH1 functions as a scafold of O-linked, 3′-sialyllactosylated glycans

Tsukamoto, Y; Aoki, K; Narimatsu, Y; Urata, Y; Saiki, W; Ogawa, M; Clausen, H; Tiemeyer, M; Okajima, T; Takeuchi, H

GLYCOBIOLOGY Vol. 30 ( 12 ) page： 1119 - 1120 2020.12

N-glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization

Alam, SMD; Tsukamoto, Y; Ogawa, M; Senoo, Y; Ikeda, K; Tashima, Y; Takeuchi, H; Okajima, T

GLYCOBIOLOGY Vol. 30 ( 12 ) page： 1031 - 1032 2020.12

Comprehensive O-GlcNAc glycoproteomics on NOTCH1 EGF repeats refined the sequons for O-GlcNAcylation and uncovered unique Lewis X epitopes in mammals

Ogawa, M; Tsukamoto, Y; Yogi, K; Senoo, Y; Ikeda, K; Takeuchi, H; Okajima, T

GLYCOBIOLOGY Vol. 30 ( 12 ) page： 1086 - 1087 2020.12

Glycoproteomic analysis identifies cryptdin-related sequence 1 as O-glycosylated protein modified with α1,2-fucose in the small intestine Reviewed

Hashiguchi, H; Tsukamoto, Y; Ogawa, M; Tashima, Y; Takeuchi, H; Nakamura, M; Kawashima, H; Fujishiro, M; Okajima, T

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS Vol. 695 page： 108653 2020.11

Differential Labeling of Glycoproteins with Alkynyl Fucose Analogs Reviewed Open Access

Ma Chenyu, Takeuchi Hideyuki, Hao Huilin, Yonekawa Chizuko, Nakajima Kazuki, Nagae Masamichi, Okajima Tetsuya, Haltiwanger Robert S., Kizuka Yasuhiko

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 21 ( 17 ) 2020.9

Aminoglycosides are efficient reagents to induce readthrough of premature termination codon in mutant B4GALNT1 genes found in families of hereditary spastic paraplegia. Open Access

Yesmin F, Bhuiyan RH, Ohmi Y, Ohkawa Y, Tajima O, Okajima T, Furukawa K, Furukawa K

Journal of biochemistry Vol. 168 ( 2 ) page： 103 - 112 2020.8

N-Glycans on EGF domain-specificO-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization Open Access

Alam Sayad Md. Didarul, Tsukamoto Yohei, Ogawa Mitsutaka, Senoo Yuya, Ikeda Kazutaka, Tashima Yuko, Takeuchi Hideyuki, Okajima Tetsuya

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 295 ( 25 ) page： 8560 - 8574 2020.6

Contribution of extracellular O-GlcNAc to the stability of folded epidermal growth factor-like domains and Notch1 trafficking

Ogawa Mitsutaka, Tashima Yuko, Sakaguchi Yamato, Takeuchi Hideyuki, Okajima Tetsuya

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 526 ( 1 ) page： 184 - 190 2020.5

Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking Open Access

Urata Yusuke, Saiki Wataru, Tsukamoto Yohei, Sago Hiroaki, Hibi Hideharu, Okajima Tetsuya, Takeuchi Hideyuki

CELLS Vol. 9 ( 5 ) 2020.5

The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface Open Access

Hashimoto Noboru, Ito Shizuka, Tsuchida Akiko, Bhuiyan Robiul H., Okajima Tetsuya, Yamamoto Akihito, Furukawa Keiko, Ohmi Yuhsuke, Furukawa Koichi

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 294 ( 28 ) page： 10833 - 10845 2019.7

Extracellular O-GlcNAc: From Discovery to Current Developments Open Access

Okajima Tetsuya

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY Vol. 31 ( 181 ) page： SE57 - SE58 2019.7

Structure and function of extracellular O-GlcNAc Invited Reviewed Open Access

Ogawa, M; Okajima, T

CURRENT OPINION IN STRUCTURAL BIOLOGY Vol. 56 page： 72 - 77 2019.6

Loss of Enzyme Activity in Mutated B4GALNT1 Gene Products in Patients with Hereditary Spastic Paraplegia Results in Relatively Mild Neurological Disorders: Similarity with Phenotypes of B4galnt1 Knockout Mice

Bhuiyan Robiul H., Ohmi Yuhsuke, Ohkawa Yuki, Zhang Pu, Takano Maiko, Hashimoto Noboru, Okajima Tetsuya, Furukawa Keiko, Furukawa Koichi

NEUROSCIENCE Vol. 397 page： 94 - 106 2019.1

Structure and function of extracellular O-GlcNAc Invited Reviewed Open Access

Mitsutaka Ogawa, Tetsuya Okajima

Current Opinion in Structural Biology Vol. 56 page： 72-77 2019

Significant roles of O-glucose glycans in mammalian Notch trafficking and signaling

Takeuchi, H; Yu, HJ; Hao, HL; Urata, Y; Senoo, Y; Tsukamoto, Y; Saiki, W; Takeuchi, M; Ito, A; Li, HL; Okajima, T; Haltiwanger, RS

GLYCOBIOLOGY Vol. 28 ( 12 ) page： 1017 - 1018 2018.12

Exploring the significance of xylosyl-extension of O-glucose glycans on EGF repeats for Notch signaling in mammals

Saiki, W; Urata, Y; Senoo, Y; Tsukamoto, Y; Ma, CY; Okajima, T; Takeuchi, H

GLYCOBIOLOGY Vol. 28 ( 12 ) page： 1028 - 1029 2018.12

Roles of asialo-series ganglioside GD1alpha in human cancer cell lines

Bhuiyan, RH; Kondo, Y; Ohkawa, Y; Ohmi, Y; Zhang, P; Okajima, T; Furukawa, K; Furukawa, K

CANCER SCIENCE Vol. 109 page： 877 - 877 2018.12

Roles of ganglioside GD3 in the regulation of microenvironment of gliomas

Zhang, P; Ohkawa, Y; Ohmi, Y; Robiul, HB; Kato, A; Furukawa, K; Okajima, T; Wakabayashi, T; Furukawa, K

CANCER SCIENCE Vol. 109 page： 262 - 262 2018.12

Whole mount staining of retina

Mitsutaka Ogawa, Tetsuya Okajima

bio-101 Vol. 8 ( 19 ) page： e3034 2018.10

Isolation of Murine Brain and Lung Microvascular Endothelial Cells Invited Reviewed

Ailing Zhang, Shogo Sawaguchi, Entzu Wan, Mitsutaka Ogawa, Tetsuya Okajima

bio-101 2018.8

Congenital diseases caused by defective O-glycosylation of Notch receptors Open Access

Tashima Yuko, Okajima Tetsuya

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 3 ) page： 299 - 307 2018.8

Structural Divergence in O-GlcNAc Glycans Displayed on Epidermal Growth Factor-like Repeats of Mammalian Notch1. Open Access

Ogawa M, Senoo Y, Ikeda K, Takeuchi H, Okajima T

Molecules (Basel, Switzerland) Vol. 23 ( 7 ) 2018.7

NOTCH SIGNALING A sweet strategy

Okajima Tetsuya

NATURE CHEMICAL BIOLOGY Vol. 14 ( 1 ) page： 3 - 4 2018.1

Ganglioside GD3/GD2 enhance malignant properties of human glioma U251 cells

Zhang, P; Iwasawa, T; Ohkawa, Y; Bhuiyan, RH; Momota, H; Wakabayashi, T; Ohmi, Y; Okajima, T; Furukawa, K; Furukawa, K

CANCER SCIENCE Vol. 109 page： 256 - 256 2018.1

Protocol for Notch-ligand Binding Assays Using Dynabeads Invited Reviewed

bio-protocol 2017.10

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals Open Access

Sawaguchi Shogo, Varshney Shweta, Ogawa Mitsutaka, Sakaidani Yuta, Yagi Hirokazu, Takeshita Kyosuke, Murohara Toyoaki, Kato Koichi, Sundaram Subha, Stanley Pamela, Okajima Tetsuya

ELIFE Vol. 6 2017.4

Neogenin defined as a GD3-associated molecule by enzyme-mediated activation of radical sources confers malignant properties via intra-cytoplasmic domain in melanoma cells. Reviewed Open Access

Kaneko K, Ohkawa Y, Hashimoto N, Ohmi Y, Kotani N, Honke K, Ogawa M, Okajima T, Furukawa K, Furukawa K

J. Biol. Chem. Vol. 291 page： 16630-16643 2016

Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated EGF domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome. Open Access

Ogawa M, Sawaguchi S, Kawai T, Nadano D, Matsuda T, Yagi H, Kato K, Furukawa K, Okajima T.

J Biol Chem page： in press 2015

O-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activation. Reviewed Open Access

Ishio A, Sasamura T, Ayukawa T, Kuroda J, Ishikawa HO, Aoyama N, Matsumoto K, Gushiken T, Okajima T, Yamakawa T, Matsuno K.

J Biol Chem page： in press 2015

Extracellular O-linked beta-N-acetylglucosamine: Its biology and relationship to human disease. Invited Reviewed

Ogawa M, Furukawa K, Okajima T.

World J Biol Chem Vol. 5 page： 224-230 2014

Allergenic potential of rice-pollen proteins: expression, immuno-cross reactivity and IgE-binding.

Vol. 154 page： 195-205 2013

Dephosphorylation reduces passage of ovalbumin antigen through intestinal epithelial Caco-2 cell monolayers.

Vol. 153 page： 347-354 2013

GTDC2 modifies O-mannosylated α-dystroglycan in the endoplasmic reticulum to generate N-acetyl-glucosamine epitopes reactive with CTD110.6 antibody. Reviewed

Vol. 440 page： 88-93 2013

Post-weaning increases in the milk-fat globule EGF-factor VIII on fat globules in mouse milk and in the uptake of the fat globules by HC11 mammary epithelial cells. Reviewed Open Access

Vol. 153 page： 31-41 2013

Trimeric Tn Antigen on Syndecan 1 Produced by ppGalNAc-T13 Enhances Cancer Metastasis via a Complex Formation with Integrin alpha5beta1 and Matrix Metalloproteinase 9. Reviewed Open Access

Vol. 288 page： 24264-24276 2013

O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1.

Vol. 419 page： 14-19 2012

pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen. Reviewed

Vol. 419 page： 7-13 2012

Discharge of solubilized and Dectin-1-reactive beta-glucan from macrophage cells phagocytizing insoluble beta-glucan particles: Involvement of reactive oxygen species (ROS)-driven degradation. Reviewed

Vol. 421 page： 329-334 2012

O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions Reviewed Open Access

Vol. 2 page： 583 2011.12

Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin Open Access

Vol. 508 page： 87-92 2011

Specific O-glycosylation modifying epidermal growth factor domains.

Vol. 83 page： 813-821 2011

Strong antibody reaction against glycosphingolipids injected in liposome-embedded forms in beta3GN-T5 knockout mice. Open Access

Vol. 73 page： 137-146 2011

Establishment of a Mammary Stromal Fibroblastic Cell Line for In Vitro Studies in Mice of Mammary Adipocyte Differentiation. Reviewed Open Access

Nakatani H, Aoki N, Okajima T, Nadano D, Flint D, Matsuda T.

Biol. Reprod. Vol. 82 page： 44-53 2010

O-GlcNAc modification on EGF domains of Notch receptors.

Sakaidani Y, Furukawa K, Okajima T.

Methods Enzymol. Vol. 480 page： 355-73 2010

Proteomic Analysis of Rodent Ribosomes Revealed Heterogeneity Including Ribosomal Proteins L10-like, L22-like 1, and L39-like. Reviewed

Sugihara Y, Honda H, Iida T, Morinaga T, Hino S, Okajima T, Matsuda T, Nadano D.

J. Proteome Res. Vol. 9 page： 1351-66 2010

IgG2 dominancy and carbohydrate recognition specificity of C3H/He mouse antibodies directed to cross-reactive carbohydrate determinants (CCDs) bearing ß-(1,2)-xylose and α-(1,3)-fucose

Vol. 133 page： 28-34 2010

Roles of glycosylation in Notch signaling.

Vol. 92 page： 131-164 2010

Binding of Norovirus virus-like particles (VLPs) to human intestinal Caco-2 cells and the sup-pressive effect of pasteurized bovine colostrum on this VLP binding. Open Access

Vol. 74 page： 541-547. 2010

Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland.

Vol. 28 page： 321-328 2010

Periodate-resistant carbohydrate epitopes recognized by IgG and IgE antibodies from some of the immunized mice and patients with allergy. Reviewed

Hino S, Matsubara T, Urisu A, Aoki N, Sato C, Okajima T, Nadano D, Matsuda T.

Biochem. Biophys Res. Commun. Vol. 380 page： 632-637 2009

Glycoconjugate glycosyltransferases. Invited Reviewed

Furukawa K, Tsuchida A, Okajima T, Furukawa K.

Glycoconj. J. Vol. 26 page： 987-998 2009

Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling Reviewed Open Access

Okajima T, Reddy B, Matsuda T and Irvine KD

BMC biology Vol. 6 ( 1 ) page： 1-26 2008.1

Serum and monoclonal IgE antibodies from NC/Nga mice with severe atopic-like dermatitis recognize an autoantigen, histone H3. Reviewed

Matsubara T, Aoki N, Hino H, Okajima T, Nadano D, Matsuda T

Clin. Exp. Allergy Vol. 39 page： 579-590 2008

Absorption, Migration and Kinetics in Peripheral Blood of Orally Administered Ovalbumin in a Mouse Model Reviewed Open Access

Matsubara T, Aoki N, Honjoh T, Mizumachi K, Kurisaki JI, Okajima T, Nadano D, Matsuda T

Biosci. Biotechnol. Biochem. Vol. 72 page： 2555-2565 2008

Suppressive expression of the glutelin A1-collagen peptide fusion gene in hybrid rice lines with the mutant line, Low Glutelin Content-1 (LGC-1) Reviewed Open Access

Hashizume F, Hino S, Okajima T, Nadano D, Aoki N and Matsuda T

Plant Biotechnol Vol. 25 page： 465-471 2008

Development and evaluation of transgenic rice seeds accumulating a type II-collagen tolerogenic peptide Reviewed

Hashizume F, Hino S, Kakehashi M, Okajima T , Nadano D, Aoki N, and Matsuda T

Transgenic Research Vol. 17 page： 1117-1129 2008

Glycoconjugate glycosyltransferases Invited Reviewed

Furukawa K, Tsuchida A, Okajima T, Furukawa K

Glycoconj. J Vol. 26 page： 987-98 2008

Engineering of a mammalian O-glycosylation pathway in the yeast Saccharomyces cerevisiae: production of O-fucosylated epidermal growth factor domains Reviewed

Yuko Chigira, Takuji Oka, Tetsuya Okajima and Yoshifumi Jigami

Glycobiology Vol. 18 page： 303-314 2008

Biological functions of glycosyltransferase genes involved in O-fucose glycan synthesis Invited Reviewed

Okajima T, Matsuura A, Matsuda T

J. Biochem. Vol. 144 page： 1-6 2008

糖転移酵素のNotch受容体フォールディングにおける役割

松浦愛子・松田幹・岡島徹也

蛋白質核酸酵素 Vol. 53 page： 1480-1485 2008

*O-linked GlcNAc is present on the extracellular domain of Notch receptors. Reviewed Open Access

Matsuura A, Ito M, Sakaidani Y, Kondo T, Murakami K, Furukawa K, Nadano D, Matsuda T, and Okajima T

J. Biol. Chem. Vol. 283 ( 51 ) page： 35486-35495 2008

Glycosyltransferases involved in O-fucose glycan synthesis.

Okajima T, Matsuda T

Experimental Glycoscience page： 33-35 2008

Association of chicken zona pellucida glycoprotein (ZP) B1 with ZPC induces formation of ZPB1-ZPC fibrous aggregates containing disulfide-bridged ZPB1 dimer. Reviewed

Okumura H, Okajima T, Nadano D, Matsuda T.

Biochem Biophys Res Commun. Vol. 364 ( 3 ) page： 682-688 2007.12

Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. Reviewed Open Access

Miyoshi M, Okajima T, Matsuda T, Fukuda MN, Nadano D.

Biochem J Vol. 404 ( 3 ) page： 373-381 2007.6

Roles of fucosyltransferase and fucose in Notch signaling Invited

Okajima T, Matuda T.

Methods Enzymol Vol. 417 page： 116-26 2006

*Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding. Reviewed

Okajima T, Xu A, Lei L, Irvine KD.

Science Vol. 307 page： 1599-603 2005.3

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Notch proteins are receptors for a conserved signaling pathway that affects numerous cell fate decisions. We found that in Drosophila, Protein O-fucosyltransferase 1 (OFUT1), an enzyme that glycosylates epidermal growth factor-like domains of Notch, also has a distinct Notch chaperone activity. OFUT1 is an endoplasmic reticulum protein, and its localization was essential for function in vivo. OFUT1 could bind to Notch, was required for the trafficking of wild-type Notch out of the endoplasmic reticulum, and could partially rescue defects in secretion and ligand binding associated with Notch point mutations. This ability of OFUT1 to facilitate folding of Notch did not require its fucosyltransferase activity. Thus, a glycosyltransferase can bind its substrate in the endoplasmic reticulum to facilitate normal folding.

DOI： 10.1126/science.1108995

*Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe. Invited Reviewed Open Access

Okajima T, Xu A, Irvine KD.

J Biol Chem. Vol. 278 page： 42340-5 2003.10

Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. Reviewed Open Access

Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K.

J Biol Chem. Vol. 278 page： 22787-94 2003.6

XGalT-1 involved in the synthesis of glyosaminoglycans of proteoglycans and Ehlers-Danlos syndrome (progeroid type) Invited

Furukawa K, Okajima T, Nakamura Y.

Tanpakushitsu Kakusan Koso. Vol. 48 ( 8 Suppl ) page： 1152-7 2003.1

*Regulation of notch signaling by O-linked fucose. Invited Reviewed Open Access

Okajima T, Irvine KD.

Cell Vol. 111 page： 893-904 2002.12

Galactosyltransferase I is a gene responsible for progeroid variant of Ehlers-Danlos syndrome: molecular cloning and identification of mutations. Invited

Furukawa K, Okajima T.

Biochim Biophys Acta. Vol. 1573 ( 3 ) page： 377-81 2002.12

Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis. Reviewed Open Access

Nakamura Y, Haines N, Chen J, Okajima T, Furukawa K, Urano T, Stanley P, Irvine KD, Furukawa K.

J Biol Chem. Vol. 277 ( 48 ) page： 46280-8 2002.11

b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. Reviewed Open Access

Okada M, Itoh Mi M, Haraguchi M, Okajima T, Inoue M, Oishi H, Matsuda Y, Iwamoto T, Kawano T, Fukumoto S, Miyazaki H, Furukawa K, Aizawa S, Furukawa K.

J Biol Chem. Vol. 277 ( 3 ) page： 1633-6 2002.1

Expression cloning of human globoside synthase cDNAs: Identification of β3Gal-T3 as UDP-N-acetylgalactosamine: globotriaosylceramide β1,3-N-acetyl-galactosaminyltransferase. Reviewed Open Access

Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata Si, Furukawa K, Urano T, Furukawa K

J. Biol. Chem. Vol. 275 page： 40498-40503 2000

Molecular basis for the p phenotype: Identification of distinct and multiple mutations in the α1,4-galactosyltransferase gene in Swedish and Japanese individuals. Reviewed Open Access

Furukawa K, Iwamura K, Uchikawa M, Sojka BN, Wiels J, Okajima T, Urano T, Furukawa K.

J. Biol. Chem. Vol. 275 page： 37752-37756 2000

Molecular cloning and expression of mouse GD1α/GT1aα/GQ1bα synthase (ST6GalNAc VI) gene. Reviewed Open Access

Okajima T, Chen HH, Ito H, Kiso M, Tai T, Furukawa K, Urano T, Furukawa K.

J. Biol. Chem. Vol. 275 page： 6717-6723 2000

Molecular cloning of Gb3/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo-series glycosphingolipids. Reviewed Open Access

Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.

J. Biol. Chem. Vol. 275 page： 15152-15156 2000

Assignment of human xylosylprotein beta-1,4-galactosyltransferase gene (B4GALT7) to human chromosome 5q35.2-->q35.3 by in situ hybridization. Reviewed

Kuroiwa A, Matsuda Y, Okajima T, Furukawa K

Cytogenet. Cell Genet. Vol. 89 page： 8-9 2000

Molecular cloning of brain-specific GD1α synthase (ST6GalNAc V) containing CAG/Glutamine repeats. Reviewed Open Access

Okajima T, Fukumoto S, Ito H, Kiso M, Hirabayashi Y, Urano T, Furukawa K, Furukawa K.

J. Biol. Chem Vol. 274 page： 30557-30562 1999

Molecular cloning of a novel α2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. Reviewed Open Access

Okajima T, Fukumoto S, Miyazaki H, Ishida H, Kiso M, Furukawa K, Urano T, Furukawa K.

J. Biol. Chem. Vol. 274 page： 11479-11486 1999

Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. Reviewed Open Access

Okajima T, Yoshida K, Kondo T, Furukawa K.

J. Biol. Chem. Vol. 274 page： 22915-22918 1999

*Molecular basis for the progeroid variant of Ehlers-Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I gene. Reviewed Open Access

Okajima T, Fukumoto S, Furukawa K, Urano T, Furukawa K.

J. Biol. Chem. Vol. 274 page： 28841-28844 1999

Nuclear localization of Ca2+/calmodulin-dependent protein kinase IV and calspermin. Reviewed Open Access

Okajima T, Okuno S, Fujisawa H, Hagiwara M.

Bioimages Vol. 4 page： 117-128 1996

RNA priming coupled with DNA synthesis on natural template by calf thymus DNA polymerase α-primase. Reviewed

Suzuki M, Savoysky E, Izuta S, Tatebe M, Okajima T, Yoshida S.

Biochemistry Vol. 32 page： 12782-92 1993

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