Faculty Profiles - SATO, Chihiro

Presentations -

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Identification of a new diSia-containing glycoprotein (adipoQ) in bovine and mouse sera

XVIth International Symposium on Glycoconjugates 2001.7.19

Glycosphingolipid enriched microdomain on gametic cells as functional domain for sperm-egg interaction coupled with signal transduction

Gordon Research Conference on Fertilization and Activation of the Development 1999.6.1

Frequent occurrence of oligosialyl units in vertebrate glycoproteins as evidenced by new chemical and immunochemical methods.

XIVth International Symposium on Glycoconjugates 1997.9.27

Egg receptor for sperm binds to gangliosides in the low density detergent-insoluble membrane (LD-DIM) domain of the sperm surface. Possible involvement of the LD-DIM in sperm-egg binding coupled with signal transduction during fertilization.

XVth International Symposium on Glycoconjugates 1999.8.1

Di- and oligosialic acids as novel carbohydrate epitopes in leukocytes

7th Conference on human leukocyte differentiation antigens 2000.6.1

Complex formation between polysialic acid and brain derived neurotrophic factor (BDNF).

Chihiro Sato, Yukihiro Kanato, Ken Kitajima

24th International Carbohydrate Symposium, 2008.7.27

Chain Length Diversity of Sialic Acids and Its Biological Significance International conference

SATO Chihiro

Trends in Glycoscience and Glycotechnology 2004.9 FCCA(Forum: Carbohydrates Coming of Age)

Language：English Presentation type：Oral presentation (general)

Sialic acids are commonly present as monosialyl residues at the non-reducing terminal end of glycoconjugates. In some cases, α2→8 linked di/oligosialic acid chains with DP 2 or 3 sialic acid residues are common structural units of gangliosides, and involved in various biological processes, such as cell adhesion, cell differentiation, signal transduction, and surface expression of stage specific antigen. In contrast, little attention has been paid to the occurrence and functions of such short sialyl di/oligomers on glycoproteins, while polysialic acid (DP≥8) in embryonic NCAM has been extensively studied as a regulator of cell adhesion in neurogenesis. As analytical methods to detect di/oligosialic acid structures have been improved, several glycoproteins containing di/oligo/polysialic acid chains have been identified. It is thus hypothesized that these di/oligosialic acid residues on glycoproteins may have similar important functions in common with those proposed for the gangliosides or may have new functions. Currently, several studies showing the importance of di/oligosialic acid-containing glycoproteins have emerged. In this review, recent advances in such studies of di/oligosialic acid residues on glycoproteins, including analytical methods, occurrence, biosynthetic pathways, and functions, are described.

Brain-derived neurotrophic factor binds to polysialic acid directly depending on degree of polymerization.

Yukihiro Kanato, Ken Kitajima, Chihiro Sato

SialoGlyco Conference 2008 2008.7

"Identification of adipo Q, an adipocyte-specific glycoprotein, as a new oligosialic acid-containing glycoprotein and a possible substrate for the a2,8-sialyltransferase III (ST8SiaIII)."

"International Symposium on Protein Traffic, Glycosylation, and Human Health" 2001.5.12

"Expression of a2,8-linked oligosialic acid-containing glycoproteins in mammalian cells, depending on development, cell differentiation, and overexpression of polysialyltransferase genes."

XIXth International Carbohydrate Symposium 1998.8.1

"Expression and glycosylation of a major, carbohydrate-rich, cortical alveolus glycoprotein (hyosophorin) during oogenesis of medaka fish, Oryzias latipes"

3rd International Symposium of the Molecular and Cellular Biology of the Egg and Embryo 2000.8.1

魚類CMP-シアル酸合成酵素の構造と性質 International conference

藤田明子, 安川裕子, 佐藤ちひろ, 北島健

日本農芸化学会2009年度大会 2009.3.29

酸性多糖と神経栄養因子との相互作用解析．

金戸幸弘, 北島健, 佐藤ちひろ

第81回日本生化学会大会 2008.12.9

糖タンパク質糖鎖におけるジおよびオリゴシアル酸の構造と機能 International conference

佐藤ちひろ

糖鎖物質設計シンポジウム 2000.8.1

昆虫細胞由来シアル酸9-リン酸合成酵素の構造と基質特異性の解析 International conference

濱口香代, 郷慎司, 佐藤ちひろ, 小林迪弘, 池田素子, 北島健

第81回日本生化学会大会 2008.12.9

抗ジシアル酸抗体が認識する急性期タンパク質の同定．

安川然太, 北島健, 佐藤ちひろ

第81回日本生化学会大会 2008.12.9

哺乳類シアロ糖タンパク質のデアミノノイラミン酸 (KDN) 修飾糖タンパク質への改変． International conference

中島優子, 藤田明子, 佐藤ちひろ, 北島健

第81回日本生化学会大会 2008.12.9

哺乳動物に見いだされるオリゴ・ポリシアル酸含有糖タンパク質ファミリーの構造と機能 International conference

佐藤ちひろ

第43回FCCAセミナー 2001.7.14

化学的検出法を用いた天然におけるサイクリックシアル酸の局在検索． International conference

岩田章子, 佐藤ちひろ, 安藤弘宗, 石田秀治, 木曽真, 神奈木玲児, 北島健

第81回日本生化学会大会 2008.12.9

ラクタム化シアル酸誘導体の合成とその分解反応に関する研究． International conference

大野ひろみ, 安藤弘宗, 川上信彦, 岩田章子, 佐藤ちひろ, 北島健, 石田秀治, 木曽真

日本農芸化学会2009年度大会 2009.3.29

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