Papers - HITOMI, Kiyotaka
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A biochemical pathway that controls skin barrier formation: expression of its key components in inflammatory skin diseases and in reconstructed skin. Reviewed
T. Cheng, G.S. Tjabringa, I.M.J.J. van Vlijmen-Willems, K. Hitomi*, P.E.J. van Erp, J.Schalkwijk, and P.L.J.M. Zeeuwen
Br. J. Dermatol. Vol. 161 page： 253-264 2009.8
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Development of an isoenzyme-specific colorimetric assay for tissue transglutaminase 2 cross-linking activity Reviewed
Perez Alea M., Kitamura, M., Martin, G., Thomas, V., Hitomi, K., El Alaoui,S.
Anal. Biochem. Vol. 389 page： 150-156 2009.6
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Colocalization of cystatin M/E and its target proteases suggests a role in terminal differentiation of human hair follicle and nail Reviewed Open Access
Cheng, T., van Vlijmen-Willems, IM, Hitomi, K., Schlkwijk, J. Zeeuwen, P.
J. Invest. Dermatol. Vol. 129 ( 5 ) page： 12132-1242 2009.5
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*Identification of preferred substrate sequences for transglutaminase 1: development of a novel peptide that can efficiently detect cross-linking enzyme activity in the skin. Reviewed
Sugimura Y, Hosono M, Kitamura M, Tsuda T, Yamanishi K, Maki M and Hitomi K.
FEBS Journal Vol. 275 page： 5667-5677 2008.11
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Identification of the preferred substrate sequences of microbial transglutaminase from Streptomyces mobaraensis using a phage-displayed peptide library. Reviewed
Sugimura Y., Yokoyama K., Nio N., Maki M., and Hitomi K.
Arch. Biophys. Biochem. Vol. 477 page： 379-383 2008.6
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Transglutaminase 2 activity promotes membrane resealing after mechanical damage in the lung cancer cell line A549 Reviewed
Kawai Y. Wada F., Sugimura Y., Maki M., and Hitomi K
Cell Biol. Int. Vol. 32 page： 928-934 2008.4
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Gene expression signatures that classify the mode of invasion of primary oral squamous cell carcinomas. Reviewed
Kondoh N, Ishikawa T, Ohkura S, Arai M, Hada A, Yamazaki Y, Kitagawa Y, Shindoh M, Takahashi M, Ando T, Sato Y, Izumo T, Hitomi K, Yamamoto M.
Mol. Carcinogen. Vol. 47 page： 744-756 2008.4
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Human calpain 7/PalBH associates with a subset of ESCRT-III-related proteins in its N-terminal region and partly localizes to endocytic membrane compartments Reviewed
Yorikawa C., Takaya E., Ohsako Y., Terasawa, Y., Hamakubo T., Mochizuki Y., Iwanari H., Kodama T., Maeda T., Hitomi K., Shibata H., Maki M.
J. Biochem. Vol. 143 page： 731-735 2008.3
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Novel site-specific immobilization of a functional protein using a preferred substrate sequence for transglutaminase 2 Reviewed
Y. Sugimura, H. Ueda, M. Maki, and K. Hitomi
Journal of Biotechnology Vol. 131 page： 121-127 2007.8
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*Identification of substrates for mammalian-type transglutaminase in Physarum polycephalum, an acellular slime mold, upon cellular mechanical damage Reviewed
Wada F., Hasegawa H., Hanai Y., Nakamura A., Sugimura Y. , Kawai Y., Sasaki N., Shibata H., Maki M. and Hitomi K
FEBS Journal Vol. 274 ( 11 ) page： 2766-2744 2007.5
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A novel strategy for generation of monoclonal antibodies from single B cells using rt-PCR technique and in vitro expression Reviewed
Jiang, X., Suzuki, H., Hanai, Y., Wada F., Hitomi, K., Yamane, T., Nakano, H
Biotechnol. Prog. Vol. 22 page： 979-988 2006.7
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Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site Reviewed
Cheng, T., Hitomi, K., Vlijmen-Willems, J. J., Jongh, G., J., Yamamoto K., Nihsi, K., Watts, C., Reinhecke, T., Schalkwijk, J. and P. Zeeuwen
The Journal of Biological Chemistry Vol. 281 ( 23 ) page： 15893-15899 2006.6
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*Screening for the preferred substrate sequence of transglutaminase using a phage-displayed peptide library Reviewed
Sugimura, Y., Hosono, M., Yoshimura, T., Maki, M., and Hitomi, K.
The Journal of Biological Chemistry Vol. 281 ( 26 ) page： 17699-17706 2006.6
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Generation of monoclonal antibodies using simplified single-cell reverse transcription-polymerase chain reaction and cell-free protein synthesis. Reviewed
Ali, M., Hitomi, K., and Nakano, H.
J. Biosci. Bioeng. Vol. 101 page： 284-286 2006.3
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Reevaluation of the predicted gene structure of dictyostelium cystatin A3 (cpiC) by nucleotide sequence determination of its cDNA and its phylogenetic position in the systatin superfamily Reviewed
El-halawany MS, Shibata, H., Hitomi, K., and Maki, M.
Molecular Biology Reports Vol. 32 ( 4 ) page： 257-264 2005.12
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Transglutaminase in the skin epidermis Invited Reviewed
Vol. 15 page： 313-319 2005.9
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"Analyses of expression and localization of two mammalian-type transglutaminases in Physarum Polycephalum, an acellular slime mold." Reviewed
"Wada, F., Ogawa, A., Hanai, Y., Nakamura, A. Maki, M., and Hitomi, K."
J. Biochem. Vol. 136 page： 665-672 2004.11
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"DdAlix, an Alix/AIP1 homolog in Dictyostelium discoideum, is required for multicellular development under low Ca2+ conditions." Reviewed
"Ohkouchi, S., Medhat, El-H., Maeda, M., Shibata, H., Hitomi, K., and Maki, M."
Gene Vol. 337 page： 131-139 2004.10
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Evidence that unrestricted legumain activity is involved in disturbed epidermal cornifcation in cystatin M/E deficient mice. Reviewed
"Zeeuwen, P.M., van Vlijmen-Willems, I., Olthuis1, D., Johansen, H.T., Hitomi, K., Hara-Nishimura, I., Powers, J. C., James, K. E., Camp, H. J., Lemmens1, R., and Schalkwijk1, J."
Hum. Mol. Genet. Vol. 13 page： 1069-1079 2004.10
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Identification of cysteine protease inhibitors that belong to cystatin family 1 in the cellular slime mold Dictyostelium discoideum. Reviewed
"Medhat, El-H., Ohkouti, S., Shibata, H., Hitomi, K., and Maki, M."
Biol. Chem. Vol. 385 page： 547-550 2004.6