Papers - HITOMI, Kiyotaka
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Distinct protein expression and activity of transglutaminases found in different epidermal tumors. Reviewed
Karashima T., Furumura M., Ishii N., Ohyama B., Saruta H., Natsuaki Y., Ohata C., Tsuruta D., Hitomi K., and Hashimoto T.
Exp. Dermatol. Vol. 23 page： 433-435 2014
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Detyrosinated Glu-tubulin is a substrate for cellular Factor XIIIA transglutaminase in differentiating osteoblast. Reviewed
Wang, S., Cui C., Hitomi K., Kaartinen M.
Amino Acids Vol. 46 page： 1513-1526 2014
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タンパク質架橋化酵素の高反応性基質の探索と活用 Invited
人見清隆
バイオサイエンスとバイオインダストリー Vol. 70 ( 6 ) page： 442-447 2012.11
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A distinct effect of transient and sustained upregulation of cellular factor XIII in the goldfish and optic nerve on optic nerve regeneration Reviewed
Sugitani, K., Ogai K., Hitomi, K., Nakamura-Yonehara K., Shintani T., Noda M., Kato S.
Neurochem. Int. Vol. 61 page： 423 2012.8
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Vena cava and aortic smooth muscle cells express transglutaminase 1 and 4 in addition to tranglutaminase 2 Reviewed
Johnson KB, Hitomi K, Itoh M, Bakker EN, , Watts SW et al.
American Journal of Physiology (circulation physiology) Vol. 302 ( 7 ) page： H1355-1366 2012.4
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Bathing suit ichthyosis with summer exacerbation: a temperature-sensitive case Reviewed
Yamamoto M., Sakaguchi Y., Itoh M., Nakagawa N., Fukunaga A., Hitomi K., Yamanishi K.
Biritish Journal of Dermatology Vol. 166 ( 3 ) page： 671-693 2012.3
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Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice Reviewed
Nakagawa N., Yamamoto M., Imai Y., Sakaguchi Y., Takizawa T., Ohta N., Yagi N., Hatta I., Hitomi K., Takizawa T., Takeda J., Tsuda T., Matsuki M. Yamanishi K.
Journal of Dermatological Sciences Vol. 65 ( 3 ) page： 196-206 2012.3
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Hornerin is a component of the epidermal cornified cell envelopes Reviewed
Henry J, Hsu C-Y, Haftek, M., Nachat R.,de Koning HD., Gardina-Galera I, Hitomi K. Balica, S., Jean-Decoster, C., Schmitt, A-M., Serre, G., SimonM
FASEB Journal ( 25 ) page： 1567-1576 2011.5
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Screening of substrate peptide sequences for tissue-type transglutaminase (TGase 2) Using T7 Phage cDNA Library. Reviewed
Sugimura Y., Yamashita H, Hitomi K.
Cytotechnology ( 63 ) page： 111-118 2011.3
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In situ detection of active transglutaminases for keratinocyte-type (TGase 1) and tissue-type (TGase 2) using fluorescence-labeled highly reactive substrate peptides. Reviewed
Itoh M., Kawamoto T., Tatsukawa H., Kojima S., Yamanishi, K., Hitomi, K.
Journal of Histochemistry and Cytochemistry ( 59 ) page： 180-187 2011.2
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Identification of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair follicles Reviewed
Yamane, A., Fukui, M., Sugimura Y., Itoh, M., Prez Alea P., Thomas V., El Alaoui S., Akiyama M., Hitomi K.
FEBS Journal Vol. 277 page： 3564–3574 2010.9
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The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea. Reviewed
Zeeuwen PM., van Vlijmen-Willems I., Cheng, T., Rodijk-Olthuis1, D., Hitomi K., Hara-Nishimura I., John S. Smyth, N., Reinheckel T., Hendriks WJ., and Schalkwijk J.
FASEB J. Vol. 24 page： 3744-3755 2010.5
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Transglutaminase1 Preferred Substrate Peptide K5 Is an Efficient Tool in Diagnosis of Lamellar Ichthyosis. Reviewed
Masashi Akiyama, Kaori Sakai, K., Teruki Yanagi, T., Fukushima, S., Ihn H., Hitomi K., and Hiroshi Shimizu, H.
Am. J. Pathol. Vol. 129 page： 2306-2309 2010.4
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*A specific colorimetric assay for measuring teranglutamianse 1 and factor XIII activities. Reviewed
Analytical Biochemistry Vol. 394 page： 281-283 2009.11
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A biochemical pathway that controls skin barrier formation: expression of its key components in inflammatory skin diseases and in reconstructed skin. Reviewed
T. Cheng, G.S. Tjabringa, I.M.J.J. van Vlijmen-Willems, K. Hitomi*, P.E.J. van Erp, J.Schalkwijk, and P.L.J.M. Zeeuwen
Br. J. Dermatol. Vol. 161 page： 253-264 2009.8
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Development of an isoenzyme-specific colorimetric assay for tissue transglutaminase 2 cross-linking activity Reviewed
Perez Alea M., Kitamura, M., Martin, G., Thomas, V., Hitomi, K., El Alaoui,S.
Anal. Biochem. Vol. 389 page： 150-156 2009.6
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Colocalization of cystatin M/E and its target proteases suggests a role in terminal differentiation of human hair follicle and nail Reviewed
Cheng, T., van Vlijmen-Willems, IM, Hitomi, K., Schlkwijk, J. Zeeuwen, P.
J. Invest. Dermatol. Vol. 129 ( 5 ) page： 12132-1242 2009.5
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*Identification of preferred substrate sequences for transglutaminase 1: development of a novel peptide that can efficiently detect cross-linking enzyme activity in the skin. Reviewed
Sugimura Y, Hosono M, Kitamura M, Tsuda T, Yamanishi K, Maki M and Hitomi K.
FEBS Journal Vol. 275 page： 5667-5677 2008.11
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Identification of the preferred substrate sequences of microbial transglutaminase from Streptomyces mobaraensis using a phage-displayed peptide library. Reviewed
Sugimura Y., Yokoyama K., Nio N., Maki M., and Hitomi K.
Arch. Biophys. Biochem. Vol. 477 page： 379-383 2008.6
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Transglutaminase 2 activity promotes membrane resealing after mechanical damage in the lung cancer cell line A549 Reviewed
Kawai Y. Wada F., Sugimura Y., Maki M., and Hitomi K
Cell Biol. Int. Vol. 32 page： 928-934 2008.4