Papers - HITOMI, Kiyotaka
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Establishment of transgenic epithelium-specific Cre-recombinase driving medaka (Oryzias latipes) by homology repair mediated knock-in Reviewed
Watanabe Y., Katsumura E., Domon T., Ishikawa Y., Oguri R., Takashima M., Meng Q., Kinoshita M., Hashimoto H., Hitomi. K.
Bioscience, Biotechnology, and Biochmistry Vol. 87 page： 1285 - 1294 2023.11
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Novel Function of Transglutaminase 2 in Extracellular Histone-Induced Acute Lung Injury Reviewed
Tomohiro Mizuno1*, Fumihiko Nagano2, Yoshimasa Ito3, Hideki Tatsukawa4, Yoshiki Shinoda4, Taishu Takeuchi4, Kazuo Takahashi5, Naotake Tsuboi3, Tadashi Nagamatsu6, Shuhei Yamada7, Shoichi Maruyama2, and Kiyotaka Hitomi.
Biochemical Biophysical Research Communication Vol. 678 page： 179 - 185 2023.10
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Development of peptide-based biosensors for detecting cross-linking and deamidation activities of transglutaminases. Invited Reviewed
Tatsukwa H., Aoyama R., Hitomi K.
Amino Acids Vol. 55 page： 806 - 819 2023.6
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Involvement of hypoxia inducible factor activity in inevitable air-exposure treatment upon differentiation in a three-dimensional keratinocyte culture Invited Reviewed
FEBS Journal Vol. 290 page： 2049 - 2063 2023.4
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Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages. Invited Reviewed
Shinoda Y., Tatsukawa H., Yonaga A., Wakita R., Takeuchi T., Tsuji T., Tanaka M., Suganami T., Hitomi K.
Cell Death and Diseases Vol. 14 page： 136 2023.3
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Biochemical characterization of medaka (Oryzias latipes) fibrinogen gamma and its gene disruption resulting in anemia as a model fish Reviewed
Meng Qi, Yuko Watanabe, Hideki Tatsukawa, Hisashi Hashimoto, Kiyotaka Hitomi
Journal of Biochemistry Vol. 172 ( 5 ) page： 293 - 302 2022.10
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Investigation of mouse amniotic fluid for stimulating ability of keratinocyte differentiation depending on the fetal stage. Invited Reviewed
Archives Biochemistry Biophysics Vol. 711 page： 1 2021.10
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Spatially Resolved Identification of Transglutaminase Substrates by Proteomics in Pulmonary Fibrosis Invited Reviewed
American Journal of Respiratory Cell Molecular Biology Vol. 65 page： 319 - 330 2021.9
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Role of Transglutaminase 2 in Cell Death, Survival, and Fibrosis Invited Reviewed
Cells Vol. 10 ( 7 ) page： 1842 2021.7
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Thrombin-deficient mutant of medaka, a model fish, displays serious retardation in blood coagulation Reviewed
Watanabe Y., Oguri R., Suzuki R., Ishikawa Y., Tatsukawa H., Hashimoto H., Hitomi K.
Bioscience Biotechnology Biochemistry Vol. 85 ( 4 ) page： 824 - 833 2021.4
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Identification and characterization of substrates crosslinked by transglutaminases in liver and kidney fibrosis Reviewed
Tatsukawa Hideki, Takeuchi Taishu, Shinoda Yoshiki, Hitomi Kiyotaka
ANALYTICAL BIOCHEMISTRY Vol. 604 page： 113629 2020.9
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Transglutaminase orthologues in medaka fish - biochemical characterization and establishment of gene-deficient mutants Reviewed
Meng Qi, Watanabe Yuko, Suzuki Risa, Oguri Rina, Tatsukawa Hideki, Hitomi Kiyotaka
ANALYTICAL BIOCHEMISTRY Vol. 604 page： 113610 2020.9
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Analysis of the expression of transglutaminases in the reconstructed human epidermis using a three-dimensional cell culture Reviewed
Teshima Hirofumi, Kato Manami, Tatsukawa Hideki, Hitomi Kiyotaka
ANALYTICAL BIOCHEMISTRY Vol. 603 page： 113606 2020.8
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Gene disruption of medaka (Oryzias latipes) orthologue for mammalian tissue-type transglutaminase (TG2) causes movement retardation. Reviewed
Watanabe Y., Okuya K., Takada Y., Kinoshita M., Yokoi S., Chisada S, Kamei Y., Tatsukawa H., Yamamoto N., Abe H., Hashimoto H., Hitomi K.
Journal of biochemistry Vol. 168 ( 3 ) page： 213 - 222 2020.4
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Studies on differentiation-dependent expression and activity of distinct transglutaminases by specific substrate peptides using three-dimensional reconstituted epidermis.
Tanabe Y, Yamane M, Kato M, Teshima H, Kuribayashi M, Tatsukawa H, Takama H, Akiyama M, Hitomi K
The FEBS journal Vol. 286 ( 13 ) page： 2536-2548 2019.7
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Detection and identification of potential transglutaminase 2 substrates in the mouse renal glomeruli
Ito Yoshimasa, Tatsukawa Hideki, Yamaguchi Hisateru, Takahashi Kazuo, Hitomi Kiyotaka, Yuzawa Yukio
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS Vol. 660 page： 11-19 2018.12
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ISOZYME-SPECIFIC IDENTIFICATION AND CHARACTERIZATION OF SUBSTRATES CROSSLINKED BY TRANSGLUTAMINASES IN LIVER FIBROSIS
Tatsukawa H., Nakagawa H., Hitomi K.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 42 page： 33A-33A 2018.8
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Higher susceptibility to osmolality of the medaka (Oryzias latipes) mutants in orthologue genes of mammalian skin transglutaminases. Reviewed
Watanabe Y., Furukawa E. Tatsukawa H., Hashimoto H., Kamei Y., Taniguchi Y., Hitomi K.,
Biosci. Biotechnol. Biochem Vol. 82 ( 7 ) page： 1165-1168 2018.7
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A granular parakeratosis animal model created by topical aluminum showed characteristic keratinocyte differentiation abnormalities including abnormal profilaggrin processing and cornified cell envelop formation
Fujii M., Kishibe M., Ueda J., Hitomi K., Ishida-Yamamoto A.
JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 138 ( 5 ) page： S68-S68 2018.5
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Isozyme-specific comprehensive characterization of transglutaminase-crosslinked substrates in kidney fibrosis. Reviewed
Tatsukawa H, Otsu R, Tani Y, Wakita R, Hitomi K.
Sci Rep Vol. 9 ( 8 ) page： 7306 2018.5
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Biochemical characterization of medaka (Oryzias latipes) orthologue for mammalian Factor XIII and establishment of gene-edited mutant. Reviewed
Horimizu R, Ogawa R, Y Watanabe, Tatsukawa H, Kinoshita M, Hashimoto H, and Hitomi K.
Vol. 284 page： 2843-2855 2017.9
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Global identification and analysis of isozyme-specific possible substrates crosslinked by transglutaminases using their substrate peptides in mouse liver fibrosis. Reviewed
Tatsukawa H., Tani Y., Otsu R., Nakagawa H., Hitomi K.
Vol. 7 page： 45049 2017.3
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Characterization of medaka orthologue of human transglutaminase 2 (OlTGT). Reviewed
Takada Y., Watanabe Y., Okuya K., Tatsukawa H., Hashimoto H, Hitomi K
Biosci. Biotechnol. Biochem. Vol. 81 ( 3 ) page： 469-474 2017.3
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FRET-based detection of isozyme-specific activities of transglutaminases
Tatsukawa H. Liu HH., Ooba S., Kamiya N., Nakanishi Y., Hitomi K.
Amino Acids Vol. 49 page： 615-623 2017.5
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Analysis on transglutaminase 1 and its substrates using specific substrate peptide in cultured keratinocytes. Reviewed
Yamane M., Sugimura K., Kawasaki H., Tatsukawa H., Hitomi K.
Biochemical Biophysical Research Comunications Vol. 478 page： 343-348 2016.9
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Biochemical characterization of medaka (Oryzias latipes) transglutaminases, OlTGK1 and OlTGK2, as orthologues of human keratinocyte-type transglutaminase.
A Kikuta, E Furukawa, R Ogawa, N Suganuma, M Saitoh,T Nishimaki, T Katsumura, Hi Oota, T Kawamoto, H Tatsukawa H Hashimoto and K Hitomi
PLOS One 2015.12
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Distribution of transglutaminase family members in mouse tissues and whole body sections.
Tatsukawa H., Abe N., Ohashi S., and Hitomi K.
Biochem Biphys Res Commun. Vol. 467 page： 10146-1051 2015.11
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Transglutaminase activity is decreased in large arteries from hypertensive rats, compared to normotensive controls. Reviewed
Petersen-Jones HG, Johnson KB, Hitomi K, Tykocki NR, Thompson JM, Watts SW.
Am J Physiol Heart Circ Physiol. Vol. 308 page： 592-602 2015.3
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Early response as shown by enhancement of transglutaminase 1 expression after cisplatin-induced acute kidney injury. Reviewed
Furukawa K., Yamane M., Tatsukawa H., Hitomi K.
Arch Biochem Biophys. Vol. 586 page： 27-32 2015.9
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Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls. Reviewed
Petersen-Jones HG, Johnson KB, Hitomi K, Tykocki NR, Thompson JM, Watts SW.
Am J Physiol Heart Circ Physiol. Vol. 308 page： 592-602 2015.3
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Tissue Transglutaminase Mediated Tumor-Stroma Interaction Promotes Pancreatic Cancer Progression. Reviewed
Lee J, Condello S., Yakubov B., Emerson R., Caperell-Grant A., Hitomi K., Xie J., Matei D.
Clin Cancer Res. Vol. 21 page： 4482-4493 2015.8
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Lamellar ichthyosis with pseudoexon activation in the transglutaminase 1 gene Reviewed
Suga Y., Tsuda T., Nagai M., Sakaguchi Y., Jitsukawa O., Yamamoto M., Hitomi K., Yamanishi K.
J. Dermatology Vol. 42 page： 642-645 2015
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Hypohidrosis plays a crucial role in the vicious circle of bathing suit ichthyosis: a case with summer exacerbation Reviewed
Washio K, Fukunaga A, Terai M, Hitomi K, Yamanishi K, Nishigori C
Acta Dermato-Venerelogica Vol. 94 page： 349-350 2014.5
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Transglutaminase activity arising from Factor XIIIA is required for stabilization and conversion of plasma fibronectin into matrix in osteoblast cultures. Reviewed
C. Cui, Wang S., Myneni VD, Hitomi K., Kaartinen M.
Bone Vol. 59 page： 127-138 2014.2
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Identification of a highly reactive substrate peptudei for transglutaminase 6 and its use in detecting TGase activity in the skin epidermis Reviewed
Fukui M., Kuramoto K., Yamasaki R., Shimizu Y., Itoh M., Kawamoto T., Hitomi K.
Vol. 280 page： 1420-1429 2013.1
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Phage-displayed peptide liberary screening for preferred human substrate peptide sequences for transglutaminase 7 Reviewed
Kuramoto K., Yamasaki R., Shimizu Y., Tatsukawa H., Hitomi K
Archives Biochemistry and Biochemistry Vol. 537 ( 1 ) page： 138-143 2013
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Variations in both TG1 and TG2 isozyme-specific in situ activities and protein expressions during mouse embryonic development. Reviewed
Itoh M., Tatsukawa H., Lee E-S, Yamanishi K., Kojima S., and Hitomi K.
J. Histochem. Cytochem. Vol. 61 page： 793-801 2013.11
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Spatial arrangement of proteins using scCro-tag: application for an in situ enzymatic microbead assay
Kojima Takaaki, Hata Jumpei, Oka Hiroya, Hayashi Kenta, Hitomi Kiyotaka, Nakano Hideo
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY Vol. 82 ( 11 ) page： 1911-1921 2018.11
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Targeting transglutaminase 2 partially restores extracellular matrix structure but not alveolar architecture in experimental bronchopulmonary dysplasia
Mizikova Ivana, Pfeffer Tilman, Nardiello Claudio, Solaligue David E. Surate, Steenbock Heiko, Tatsukawa Hideki, Silva Diogo M., Vadasz Istvan, Herold Susanne, Pease Richard J., Iismaa Siiri E., Hitomi Kiyotaka, Seeger Werner, Brinckmann Juergen, Morty Rory E.
FEBS JOURNAL Vol. 285 ( 16 ) page： 3056-3076 2018.8
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Factor XIII-A transglutaminase acts as a switch between preadipocyte proliferation and differentiation. Reviewed
Myneni VD, Hitomi K., Kaartinen M.
Blood Vol. 124 page： 1344-1353 2014
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Distinct protein expression and activity of transglutaminases found in different epidermal tumors. Reviewed
Karashima T., Furumura M., Ishii N., Ohyama B., Saruta H., Natsuaki Y., Ohata C., Tsuruta D., Hitomi K., and Hashimoto T.
Exp. Dermatol. Vol. 23 page： 433-435 2014
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Detyrosinated Glu-tubulin is a substrate for cellular Factor XIIIA transglutaminase in differentiating osteoblast. Reviewed
Wang, S., Cui C., Hitomi K., Kaartinen M.
Amino Acids Vol. 46 page： 1513-1526 2014
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タンパク質架橋化酵素の高反応性基質の探索と活用 Invited
人見清隆
バイオサイエンスとバイオインダストリー Vol. 70 ( 6 ) page： 442-447 2012.11
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A distinct effect of transient and sustained upregulation of cellular factor XIII in the goldfish and optic nerve on optic nerve regeneration Reviewed
Sugitani, K., Ogai K., Hitomi, K., Nakamura-Yonehara K., Shintani T., Noda M., Kato S.
Neurochem. Int. Vol. 61 page： 423 2012.8
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Vena cava and aortic smooth muscle cells express transglutaminase 1 and 4 in addition to tranglutaminase 2 Reviewed
Johnson KB, Hitomi K, Itoh M, Bakker EN, , Watts SW et al.
American Journal of Physiology (circulation physiology) Vol. 302 ( 7 ) page： H1355-1366 2012.4
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Bathing suit ichthyosis with summer exacerbation: a temperature-sensitive case Reviewed
Yamamoto M., Sakaguchi Y., Itoh M., Nakagawa N., Fukunaga A., Hitomi K., Yamanishi K.
Biritish Journal of Dermatology Vol. 166 ( 3 ) page： 671-693 2012.3
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Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice Reviewed
Nakagawa N., Yamamoto M., Imai Y., Sakaguchi Y., Takizawa T., Ohta N., Yagi N., Hatta I., Hitomi K., Takizawa T., Takeda J., Tsuda T., Matsuki M. Yamanishi K.
Journal of Dermatological Sciences Vol. 65 ( 3 ) page： 196-206 2012.3
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Hornerin is a component of the epidermal cornified cell envelopes Reviewed
Henry J, Hsu C-Y, Haftek, M., Nachat R.,de Koning HD., Gardina-Galera I, Hitomi K. Balica, S., Jean-Decoster, C., Schmitt, A-M., Serre, G., SimonM
FASEB Journal ( 25 ) page： 1567-1576 2011.5
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Screening of substrate peptide sequences for tissue-type transglutaminase (TGase 2) Using T7 Phage cDNA Library. Reviewed
Sugimura Y., Yamashita H, Hitomi K.
Cytotechnology ( 63 ) page： 111-118 2011.3
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In situ detection of active transglutaminases for keratinocyte-type (TGase 1) and tissue-type (TGase 2) using fluorescence-labeled highly reactive substrate peptides. Reviewed
Itoh M., Kawamoto T., Tatsukawa H., Kojima S., Yamanishi, K., Hitomi, K.
Journal of Histochemistry and Cytochemistry ( 59 ) page： 180-187 2011.2
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Identification of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair follicles Reviewed
Yamane, A., Fukui, M., Sugimura Y., Itoh, M., Prez Alea P., Thomas V., El Alaoui S., Akiyama M., Hitomi K.
FEBS Journal Vol. 277 page： 3564–3574 2010.9
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The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea. Reviewed
Zeeuwen PM., van Vlijmen-Willems I., Cheng, T., Rodijk-Olthuis1, D., Hitomi K., Hara-Nishimura I., John S. Smyth, N., Reinheckel T., Hendriks WJ., and Schalkwijk J.
FASEB J. Vol. 24 page： 3744-3755 2010.5
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Transglutaminase1 Preferred Substrate Peptide K5 Is an Efficient Tool in Diagnosis of Lamellar Ichthyosis. Reviewed
Masashi Akiyama, Kaori Sakai, K., Teruki Yanagi, T., Fukushima, S., Ihn H., Hitomi K., and Hiroshi Shimizu, H.
Am. J. Pathol. Vol. 129 page： 2306-2309 2010.4
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*A specific colorimetric assay for measuring teranglutamianse 1 and factor XIII activities. Reviewed
Analytical Biochemistry Vol. 394 page： 281-283 2009.11
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A biochemical pathway that controls skin barrier formation: expression of its key components in inflammatory skin diseases and in reconstructed skin. Reviewed
T. Cheng, G.S. Tjabringa, I.M.J.J. van Vlijmen-Willems, K. Hitomi*, P.E.J. van Erp, J.Schalkwijk, and P.L.J.M. Zeeuwen
Br. J. Dermatol. Vol. 161 page： 253-264 2009.8
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Development of an isoenzyme-specific colorimetric assay for tissue transglutaminase 2 cross-linking activity Reviewed
Perez Alea M., Kitamura, M., Martin, G., Thomas, V., Hitomi, K., El Alaoui,S.
Anal. Biochem. Vol. 389 page： 150-156 2009.6
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Colocalization of cystatin M/E and its target proteases suggests a role in terminal differentiation of human hair follicle and nail Reviewed
Cheng, T., van Vlijmen-Willems, IM, Hitomi, K., Schlkwijk, J. Zeeuwen, P.
J. Invest. Dermatol. Vol. 129 ( 5 ) page： 12132-1242 2009.5
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*Identification of preferred substrate sequences for transglutaminase 1: development of a novel peptide that can efficiently detect cross-linking enzyme activity in the skin. Reviewed
Sugimura Y, Hosono M, Kitamura M, Tsuda T, Yamanishi K, Maki M and Hitomi K.
FEBS Journal Vol. 275 page： 5667-5677 2008.11
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Identification of the preferred substrate sequences of microbial transglutaminase from Streptomyces mobaraensis using a phage-displayed peptide library. Reviewed
Sugimura Y., Yokoyama K., Nio N., Maki M., and Hitomi K.
Arch. Biophys. Biochem. Vol. 477 page： 379-383 2008.6
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Transglutaminase 2 activity promotes membrane resealing after mechanical damage in the lung cancer cell line A549 Reviewed
Kawai Y. Wada F., Sugimura Y., Maki M., and Hitomi K
Cell Biol. Int. Vol. 32 page： 928-934 2008.4
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Gene expression signatures that classify the mode of invasion of primary oral squamous cell carcinomas. Reviewed
Kondoh N, Ishikawa T, Ohkura S, Arai M, Hada A, Yamazaki Y, Kitagawa Y, Shindoh M, Takahashi M, Ando T, Sato Y, Izumo T, Hitomi K, Yamamoto M.
Mol. Carcinogen. Vol. 47 page： 744-756 2008.4
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Human calpain 7/PalBH associates with a subset of ESCRT-III-related proteins in its N-terminal region and partly localizes to endocytic membrane compartments Reviewed
Yorikawa C., Takaya E., Ohsako Y., Terasawa, Y., Hamakubo T., Mochizuki Y., Iwanari H., Kodama T., Maeda T., Hitomi K., Shibata H., Maki M.
J. Biochem. Vol. 143 page： 731-735 2008.3
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Novel site-specific immobilization of a functional protein using a preferred substrate sequence for transglutaminase 2 Reviewed
Y. Sugimura, H. Ueda, M. Maki, and K. Hitomi
Journal of Biotechnology Vol. 131 page： 121-127 2007.8
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*Identification of substrates for mammalian-type transglutaminase in Physarum polycephalum, an acellular slime mold, upon cellular mechanical damage Reviewed
Wada F., Hasegawa H., Hanai Y., Nakamura A., Sugimura Y. , Kawai Y., Sasaki N., Shibata H., Maki M. and Hitomi K
FEBS Journal Vol. 274 ( 11 ) page： 2766-2744 2007.5
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A novel strategy for generation of monoclonal antibodies from single B cells using rt-PCR technique and in vitro expression Reviewed
Jiang, X., Suzuki, H., Hanai, Y., Wada F., Hitomi, K., Yamane, T., Nakano, H
Biotechnol. Prog. Vol. 22 page： 979-988 2006.7
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Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site Reviewed
Cheng, T., Hitomi, K., Vlijmen-Willems, J. J., Jongh, G., J., Yamamoto K., Nihsi, K., Watts, C., Reinhecke, T., Schalkwijk, J. and P. Zeeuwen
The Journal of Biological Chemistry Vol. 281 ( 23 ) page： 15893-15899 2006.6
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*Screening for the preferred substrate sequence of transglutaminase using a phage-displayed peptide library Reviewed
Sugimura, Y., Hosono, M., Yoshimura, T., Maki, M., and Hitomi, K.
The Journal of Biological Chemistry Vol. 281 ( 26 ) page： 17699-17706 2006.6
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Generation of monoclonal antibodies using simplified single-cell reverse transcription-polymerase chain reaction and cell-free protein synthesis. Reviewed
Ali, M., Hitomi, K., and Nakano, H.
J. Biosci. Bioeng. Vol. 101 page： 284-286 2006.3
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Reevaluation of the predicted gene structure of dictyostelium cystatin A3 (cpiC) by nucleotide sequence determination of its cDNA and its phylogenetic position in the systatin superfamily Reviewed
El-halawany MS, Shibata, H., Hitomi, K., and Maki, M.
Molecular Biology Reports Vol. 32 ( 4 ) page： 257-264 2005.12
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Transglutaminase in the skin epidermis Invited Reviewed
Vol. 15 page： 313-319 2005.9
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"Analyses of expression and localization of two mammalian-type transglutaminases in Physarum Polycephalum, an acellular slime mold." Reviewed
"Wada, F., Ogawa, A., Hanai, Y., Nakamura, A. Maki, M., and Hitomi, K."
J. Biochem. Vol. 136 page： 665-672 2004.11
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"DdAlix, an Alix/AIP1 homolog in Dictyostelium discoideum, is required for multicellular development under low Ca2+ conditions." Reviewed
"Ohkouchi, S., Medhat, El-H., Maeda, M., Shibata, H., Hitomi, K., and Maki, M."
Gene Vol. 337 page： 131-139 2004.10
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Evidence that unrestricted legumain activity is involved in disturbed epidermal cornifcation in cystatin M/E deficient mice. Reviewed
"Zeeuwen, P.M., van Vlijmen-Willems, I., Olthuis1, D., Johansen, H.T., Hitomi, K., Hara-Nishimura, I., Powers, J. C., James, K. E., Camp, H. J., Lemmens1, R., and Schalkwijk1, J."
Hum. Mol. Genet. Vol. 13 page： 1069-1079 2004.10
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Identification of cysteine protease inhibitors that belong to cystatin family 1 in the cellular slime mold Dictyostelium discoideum. Reviewed
"Medhat, El-H., Ohkouti, S., Shibata, H., Hitomi, K., and Maki, M."
Biol. Chem. Vol. 385 page： 547-550 2004.6
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Immunological detection of proteolytically activated epidermal-type transglutaminase (TGase 3) using cleavage site specific antibody Reviewed
"Hitomi, K., Ikeda, N., and Maki, M."
Biosci. Biotechnol. Biochem. Vol. 67 page： 2492-2494 2003.11
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Analysis of epidermal-type transglutaminase in human stratified epithelia and cultured keratinocytes using monospecific antibodies Reviewed
"Hitomi, K., Nakayama, T., Presland, R.B., Fleckman, P., Dale, B. A., and Maki , M."
J. Dermatol. Sci. Vol. 32 page： 95-103 2003.7
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Molecular Evolution of Transglutaminase: from bacteria to animal Invited
"Hitomi, K."
Recent Research Developmemts in Biophysics and Biochemistry Vol. 3 page： 223-234 2003.1
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Identification of Mammalian-type Transglutaminase in Physarum polycephalum: Evidences from cDNA sequence and involvement of GTP in the regulation of transamidating activity Reviewed
"Wada, F., Nakamura, Masutani, T., A., Ikura, K., Maki, M., and Hitomi K."
Eur. J. Biochem. Vol. 269 page： 3451-3460 2002.9
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Identification and Characterization of Two Penta-EF-Hand Ca(2+)-Binding Proteins in Dictyostelium discoideum Reviewed
"Ohkouchi S., Nishio K., Maeda, M., Hitomi K., Adachi H., and Maki M."
J. Biochem (Tokyo). Vol. 130 page： 207-215 2001.8
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Analysis of Epidermal Transglutaminase (TGase3) Expression in Mouse Tissues and Cell Lines Reviewed
"Hitomi, K., Horio, Y., Ikura, K., Yamanishi, K., and Maki, M."
Int. J. Biochem. & Cell Biol Vol. 33 page： 491-498 2001.6
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"Peflin and ALG-2, Members of the Penta-EF-Hand Protein Family, Form a Heterodimer that Dissociates in a Ca2+-Dependent Manner"
"Kitaura, Y., Matumoto S., Satoh,H., Hitomi, K., and Maki, M."
J. Biol. Chem Vol. 276 page： 14503-14508 2001.4
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Characterization of human recombinant transglutaminase 1 purified from baculovirus-infected insect cells Reviewed
"Hitomi K., Ymagiwa, Y., Ikura, K., Yamanishi, K., and Maki, M."
Biosci. Biochem. Biochem. Vol. 64 page： 2128-2137 2000.10
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Four types of calpastatin isoforms with distinct amino-terminal sequences are specified by alternative first exons and differentially expressed in mouse tissues
"Takano, J., Watanabe, M., Hitomi, K., and Maki, M."
Journal of Biochemistry Vol. 128 page： 83-92 2000.6
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"GTP, an Inhibitor of Transglutaminases, is Hydrolyzed by Tissue-type Transglutaminase(TGase 2)"
"Hitomi, K., Ikura, K., and Maki, M."
Biochem. Biosci. Biotechnol. Vol. 64 page： 657-659 2000.4
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"Peflin, a novel member of the five-EF-hand-protein family, is similar to the Apoptosis-linked-gene 2 (ALG-2) protein but possesses nonapeptide repeats in the N-terminal hydrophobic region."
"Kitaura, Y., Sato, H., Watanabe, M., Kawai, T., Hitomi, K., and Maki, M."
Biochem. Biophys. Res. Commun Vol. 263 page： 68-75 1999.10
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Purification of recombinant calpastatin in Escherichia coli
"Maki, M. and Hitomi, K"
Methods in Molecular Biology Vol. 144 page： 85-94 1999.1
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Structure of mouse calpastatin isoforms:Implication of species-common and species-specific alternative splicing Reviewed
"Takano J., Kawamura T., Murase, M., Hitomi, K., and Maki, M."
Biochemcal and Biophysical Research Communication Vol. 260 page： 339-345 1999.1
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Characterization of recombinant mouse epidermal-type transglutaminase (TGase 3):Regulation of its activity by proteolysis and guanine nucleotides. Reviewed
"Hitomi, K., Kanehiro, S., Ikura, K., and Maki, M."
Journal of Biochemistry Vol. 125 page： 1048-1054 1999.1
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Preparation of calpastatin Samples for Western blotting
"Maki, M. and Hitomi, K."
Methods in Molecular Biology Vol. 144 page： 95-98 1999.1
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Purification of recombinant calpastatin in Escherichia coli Invited
Methods in Molecular Biology Vol. 144 page： 85 1999
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Preparation of calpastatin samples for Western blotting Invited
Methods in Molecular Biology Vol. 144 page： 95 1999
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Regulation of matrix metalloproteinase-9 a inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Reviewed
"Takahashi C., Sheng, Z., Horan, T. P., Kitayama, H., Maki, M., Hitomi, K., Kitaura, Y., Takai, S., Sasahara, R.M., Horimoto, R., Ikawa, Y., Ratzkin, B., Arakawa, T., and Noda, M.,"
Proceedings of the National Academy of Sciences of the U.S.A. Vol. 95 page： 13221-13226 1998.10
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Expression of biologically active human calpastatin in baculovirus-infected insect cells a in Ecsherichia coli. Reviewed
"Hitomi, K. , Yokoyama, A., and Maki, M.,"
"Bioscience, Biotechnology, a Biochemistry" Vol. 62 page： 136-141 1998.1
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Purification a characterization of the active-site-mutated recombinant human μ-calpain in baculovirus-infected Insect cells.
"Hitomi, K., Uchiyama, Y., Ohkubo, I., Kunimatsu, M., Sasaki, M., and Maki, M.,"
Biochemcal a Biophysical Research Communication Vol. 246 page： 681-685 1998.1
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Ascorbate-depeent enhancement of nitric oxide formation in activated macrophages
"Mizutani, A., Maki, H., Torii, Y., Hitomi, K., and Tsukagoshi, N.,"
Nitric Oxide Vol. 2 page： 235-241 1998.1
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Calcium-iuced exposure of hydrophobic surface on mouse ALG-2 which is a member of the penta-EF-ha protein family.
"Maki, M., Yamaguchi, K., Kitaura, Y., Sato, H., and Hitomi, K.,"
Journal of Biochemistry (Tokyo) Vol. 124 page： 1170-1177 1998.1
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A growing family of the calcium-binding proteins with five EF-hand motifs
"Maki, M., Narayam, A.V.L., and Hitomi, K"
Biochem. J Vol. 328 page： 718-720 1997.1
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Functional properties of recombinant calpain I a of mutants lacking domains III a IV of the catalytic subunit.
"Vilei, E.M. , Calderara, S., Anagli, J., Berardi, S., Hitomi, K., Maki, M., and Carafoli, E.,"
Journal of Biological Chemistry Vol. 272 page： 25802-25808 1997.1
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Ascorbate-dependent expression of ubiquitin genes in guinea pigs. Reviewed
"Mizutani, A., Nagkagawa, N., Hitomi, K., and Tsukagoshi, N.,"
International Journal of Biochemistry a Cell Biology Vol. 29 page： 575-582 1997.1
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Functional properties of reconbinant calpain I and of mutants lacking domains III and IV of the catalyfic subunit(共著) Reviewed
J. Biol. Chem. Vol. 272 page： 25802 1997
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Ascorbic acid:Role of Ascorbic Acid on Modulation of Gene Expression
"Hitomi, K. and Tsukagoshi, N."
Subcellular Biochemistry (Plenum Publishing Co.) Vol. 25 page： 41-56 1996.1
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Demonstration of alkaline phosphatase participation in the mineralization of osteoblasts by antisense RNA approach.
"Torii Y., Hitomi K., Yamagishi Y., and Tsukagoshi N.,"
Cell Biology International Vol. 20 page： 459-464 1996.1
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4-hydroxy-2-nonenal cytotoxitciy in renal proximal tubular cells: Protein modification a redox alteration.
"Fukuda, A., Osawa, T., Hitomi, K., and Uchida, K.,"
Archives of Biochemistry a Biophysics Vol. 333 page： 419-426 1996.1
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Synergistic effect of BMP-2 a ascorbate on the phenotypic expression of osteoblastic MC3T3- E1. Reviewed
"Torii Y., Hitomi K., and Tsukagoshi N.,"
Molecular and Cellular Biochemistry Vol. 165 page： 25-29 1996.1
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cDNA sequence for rKST-1, a novel member of the sodium ior dependent glucose cotransporfer family Reviewed
Biochimica et Biophysica Acta Vol. 1190 ( 2 ) page： 469 1994
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L-Ascorbic Acid 2-Phosphate promotes osteoblastic differentiation of MC3T3-E1 Mediated by Accumulation of Type I Collagen (共著)
Journal of Nutritional Science and Vitaminology Vol. 40 page： 229-238 1994
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Ascorbate-dependent elevation of mRNA levels for cytochrome P450s induced by polychlorinated biphenyls
Biochemical Pharmacology Vol. 46 ( 1 ) page： 186 1993
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Increase in the activity of Alkaline Phosphatase by L-Ascorbic Acid 2-phosphate in a Human Oskoblast Cell Line, HuO-3N1
Journal of Nutritional Science and Uitaminology Vol. 38 page： 535 1992
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Recombinant Human Erythropoietir and Its Receptor
Trends in Animal Cell Culture Technology 1990
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Establishment of an erythroid cell line (JK-1) that spontaneously differentiation to red cells(共著)
Cancer Vol. 66 page： 1544-1541 1990
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Expression of the Erythropoietin Receptor on a Human Myeloma Cell Line
Biochemical Biophysical Research Communication page： 170 1990
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Solubilization and Characterization of Erythropoietin Receptor from Transplantable Mouse Erythroblastic Leukemic cell Line.
Biochemical Biophysical Research Communication page： 160 1989
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Continuous Production of erythropoietin with Immobilized Animal Cells(共著)
Applied Microbiology Biotechnology Vol. 29 page： 544 1988
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Stromal Cell-dependent Growth of Leukemic Cells from Murine Erythroblastic Leukemia(共著)
Japanese Journal of Cancer Research Vol. 79 page： 931 1988
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Production of Erythropoietin by BHK Cells Growing on the Microcarriers Trapped in Alginate Cells(共著)
Cytotechnology Vol. 2 page： 141-145 1988
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Erythropoietin Receptor of a Human leukemic Cell Line with Erythroid Characteristics
Biochemical Biophysical Research Communication page： 79 1988
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食品・医薬品分野における蛋白質テーラリング(共訳)
学会出版センター 1988
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Characterization of Erythropoietin Receptor of Murine Erythroid Cells.
European Journal of Biochemistry page： 168 1987
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Isolation and Characterization of cDNA Encoding Rabbit Reticulocyte 2,3-Bisphospho-glycerate synthase
Gene page： 44 1986