研究者詳細 - 小田　昌宏

論文 - 小田　昌宏

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ラベル拡張法によるマイクロCT像中の小葉間隔壁の抽出

深井大輔, 小田紘久, 林雄一郎, 鄭通, 中村彰太, 小田昌宏, 森健策

日本コンピュータ外科学会誌 25 巻 ( 3 ) 頁： 259 - 259 2023年11月

Automated Detection and Diagnosis of Spinal Schwannomas and Meningiomas Using Deep Learning and Magnetic Resonance Imaging

Ito Sadayuki, Nakashima Hiroaki, Segi Naoki, Ouchida Jun, Oda Masahiro, Yamauchi Ippei, Oishi Ryotaro, Miyairi Yuichi, Mori Kensaku, Imagama Shiro

JOURNAL OF CLINICAL MEDICINE 12 巻 ( 15 ) 2023年8月

記述言語：英語出版者・発行元：Journal of Clinical Medicine

Spinal cord tumors are infrequently identified spinal diseases that are often difficult to diagnose even with magnetic resonance imaging (MRI) findings. To minimize the probability of overlooking these tumors and improve diagnostic accuracy, an automatic diagnostic system is needed. We aimed to develop an automated system for detecting and diagnosing spinal schwannomas and meningiomas based on deep learning using You Only Look Once (YOLO) version 4 and MRI. In this retrospective diagnostic accuracy study, the data of 50 patients with spinal schwannomas, 45 patients with meningiomas, and 100 control cases were reviewed, respectively. Sagittal T1-weighted (T1W) and T2-weighted (T2W) images were used for object detection, classification, training, and validation. The object detection and diagnosis system was developed using YOLO version 4. The accuracies of the proposed object detections based on T1W, T2W, and T1W + T2W images were 84.8%, 90.3%, and 93.8%, respectively. The accuracies of the object detection for two spine surgeons were 88.9% and 90.1%, respectively. The accuracies of the proposed diagnoses based on T1W, T2W, and T1W + T2W images were 76.4%, 83.3%, and 84.1%, respectively. The accuracies of the diagnosis for two spine surgeons were 77.4% and 76.1%, respectively. We demonstrated an accurate, automated detection and diagnosis of spinal schwannomas and meningiomas using the developed deep learning-based method based on MRI. This system could be valuable in supporting radiological diagnosis of spinal schwannomas and meningioma, with a potential of reducing the radiologist’s overall workload.

DOI： 10.3390/jcm12155075

Artificial intelligence in a prediction model for postendoscopic retrograde cholangiopancreatography pancreatitis

Takahashi Hidekazu, Ohno Eizaburo, Furukawa Taiki, Yamao Kentaro, Ishikawa Takuya, Mizutani Yasuyuki, Iida Tadashi, Shiratori Yoshimune, Oyama Shintaro, Koyama Junji, Mori Kensaku, Hayashi Yuichiro, Oda Masahiro, Suzuki Takahisa, Kawashima Hiroki

DIGESTIVE ENDOSCOPY 2023年7月

記述言語：英語出版者・発行元：Digestive Endoscopy

Objectives: In this study we aimed to develop an artificial intelligence-based model for predicting postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). Methods: We retrospectively reviewed ERCP patients at Nagoya University Hospital (NUH) and Toyota Memorial Hospital (TMH). We constructed two prediction models, a random forest (RF), one of the machine-learning algorithms, and a logistic regression (LR) model. First, we selected features of each model from 40 possible features. Then the models were trained and validated using three fold cross-validation in the NUH cohort and tested in the TMH cohort. The area under the receiver operating characteristic curve (AUROC) was used to assess model performance. Finally, using the output parameters of the RF model, we classified the patients into low-, medium-, and high-risk groups. Results: A total of 615 patients at NUH and 544 patients at TMH were enrolled. Ten features were selected for the RF model, including albumin, creatinine, biliary tract cancer, pancreatic cancer, bile duct stone, total procedure time, pancreatic duct injection, pancreatic guidewire-assisted technique without a pancreatic stent, intraductal ultrasonography, and bile duct biopsy. In the three fold cross-validation, the RF model showed better predictive ability than the LR model (AUROC 0.821 vs. 0.660). In the test, the RF model also showed better performance (AUROC 0.770 vs. 0.663, P = 0.002). Based on the RF model, we classified the patients according to the incidence of PEP (2.9%, 10.0%, and 23.9%). Conclusion: We developed an RF model. Machine-learning algorithms could be powerful tools to develop accurate prediction models.

DOI： 10.1111/den.14622

肺マイクロCT像中の小葉間隔壁抽出のための教師データ生成に関する検討

深井大輔, 小田紘久, 林雄一郎, 鄭通, 中村彰太, 小田昌宏, 森健策

日本医用画像工学会大会予稿集 42回巻頁： 153 - 154 2023年7月

記述言語：日本語出版者・発行元：(一社)日本医用画像工学会

本稿では,肺マイクロCT像における小葉間隔壁抽出のための教師データ生成手法について述べる.マイクロCTとよばれる高解像度CT撮像装置により,肺の微細構造を撮像可能となった.肺マイクロCT像による三次元的な肺微細構造解析に基づく病態や生体機能のさらなる解明が期待される.肺微細構造の一つである小葉間隔壁の構造を明らかにするため,我々はマイクロCT像からの小葉間隔壁の構造抽出を目指す.マイクロCT像における小葉間隔壁の教師データ作成の負担は大きい.本稿では,教師データ生成の負担軽減のため,二次元画像のみのラベル付与から,三次元画像のラベル画像を得る方法を検討する.本手法で得たラベル画像から5枚の断面画像をランダムに取り出して評価したところ,平均のDice係数は0.75だった.本手法によって得られたラベル画像を元に,手動で断面画像の教師データ生成を行ったところ,作業時間が27～30分から5～7分に短縮された.(著者抄録)

2.5次元特徴抽出及び3次元特徴選択によるCOVID-19自動分類モデルの汎化性能に関する検討

遠田涼, 伊東隼人, 小田昌宏, 林雄一郎, 大竹義人, 橋本正弘, 明石敏昭, 青木茂樹, 森健策

日本医用画像工学会大会予稿集 42回巻頁： 209 - 210 2023年7月

記述言語：日本語出版者・発行元：(一社)日本医用画像工学会

本稿では,2.5次元の特徴抽出及び3次元の特徴選択によるCOVID-19自動分類用CNNを提案し,その汎化性能を複数のデータセットを用いて検証する.新型コロナウイルス感染症(COVID-19)の診断において,胸部CT検査は不可欠であるが,CT画像の読影は放射線科医らにとって負担が大きく,コンピュータ支援診断技術の開発が求められている.COVID-19の流行初期から様々な自動分類モデルが提案されてきたが,その多くは小規模な内部データセットで分類性能を検証するに留まっており,汎用的なモデルは少数である.本研究では,2次元及び3次元の特徴抽出器を組み合わせることで過学習を抑制した2.5次元のCNNと,抽出された特徴から重要なパターンのみを選択する3次元のattention機構を有する分類モデルを提案し,その汎化性能を検証する.提案モデルを含めて6種類のモデルを用いた比較の結果,提案モデルは複数のデータセットで安定した分類性能を示した.(著者抄録)

DEVELOPMENT OF A MACHINE-LEARNING MODEL FOR PREDICTING POST-ERCP PANCREATITIS

Takahashi Hidekazu, Eizaburo Ohno, Taiki Furukawa, Kentaro Yamao, Takuya Ishikawa, Yasuyuki Mizutani, Tadashi Iida, Yoshimune Shiratori, Shintaro Oyama, Junji Koyama, Kensaku Mori, Yuichiro Hayashi, Masahiro Oda, Takahisa Suzuki, Hiroki Kawashima

Gastrointestinal Endoscopy 97 巻 ( 6 ) 頁： AB656 - AB656 2023年6月

Gaussian affinity and GIoU-based loss for perforation detection and localization from colonoscopy videos

Jiang Kai, Itoh Hayato, Oda Masahiro, Okumura Taishi, Mori Yuichi, Misawa Masashi, Hayashi Takemasa, Kudo Shin-Ei, Mori Kensaku

INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY 18 巻 ( 5 ) 頁： 795 - 805 2023年5月

記述言語：英語出版者・発行元：International Journal of Computer Assisted Radiology and Surgery

Purpose: Endoscopic submucosal dissection (ESD) is a minimally invasive treatment for early gastric cancer. However, perforations may happen and cause peritonitis during ESD. Thus, there is a potential demand for a computer-aided diagnosis system to support physicians in ESD. This paper presents a method to detect and localize perforations from colonoscopy videos to avoid perforation ignoring or enlarging by ESD physicians. Method: We proposed a training method for YOLOv3 by using GIoU and Gaussian affinity losses for perforation detection and localization in colonoscopic images. In this method, the object functional contains the generalized intersection over Union loss and Gaussian affinity loss. We propose a training method for the architecture of YOLOv3 with the presented loss functional to detect and localize perforations precisely. Results: To qualitatively and quantitatively evaluate the presented method, we created a dataset from 49 ESD videos. The results of the presented method on our dataset revealed a state-of-the-art performance of perforation detection and localization, which achieved 0.881 accuracy, 0.869 AUC, and 0.879 mean average precision. Furthermore, the presented method is able to detect a newly appeared perforation in 0.1 s. Conclusions: The experimental results demonstrated that YOLOv3 trained by the presented loss functional were very effective in perforation detection and localization. The presented method can quickly and precisely remind physicians of perforation happening in ESD. We believe a future CAD system can be constructed for clinical applications with the proposed method.

DOI： 10.1007/s11548-022-02821-x

Correction to: Gaussian affinity and GIoU-based loss for perforation detection and localization from colonoscopy videos.

Jiang K, Itoh H, Oda M, Okumura T, Mori Y, Misawa M, Hayashi T, Kudo SE, Mori K

International journal of computer assisted radiology and surgery 18 巻 ( 5 ) 頁： 807 2023年5月

Deep learning-based prediction model for postoperative complications of cervical posterior longitudinal ligament ossification. 査読有り

Ito S, Nakashima H, Yoshii T, Egawa S, Sakai K, Kusano K, Tsutui S, Hirai T, Matsukura Y, Wada K, Katsumi K, Koda M, Kimura A, Furuya T, Maki S, Nagoshi N, Nishida N, Nagamoto Y, Oshima Y, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Miyagi M, Kaito T, Yamada K, Banno T, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Oda M, Mori K, Taneichi H, Kawaguchi Y, Takeshita K, Matsumoto M, Yamazaki M, Okawa A, Imagama S

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2023年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Spine Journal

Purpose: Postoperative complication prediction helps surgeons to inform and manage patient expectations. Deep learning, a model that finds patterns in large samples of data, outperform traditional statistical methods in making predictions. This study aimed to create a deep learning-based model (DLM) to predict postoperative complications in patients with cervical ossification of the posterior longitudinal ligament (OPLL). Methods: This prospective multicenter study was conducted by the 28 institutions, and 478 patients were included in the analysis. Deep learning was used to create two predictive models of the overall postoperative complications and neurological complications, one of the major complications. These models were constructed by learning the patient's preoperative background, clinical symptoms, surgical procedures, and imaging findings. These logistic regression models were also created, and these accuracies were compared with those of the DLM. Results: Overall complications were observed in 127 cases (26.6%). The accuracy of the DLM was 74.6 ± 3.7% for predicting the overall occurrence of complications, which was comparable to that of the logistic regression (74.1%). Neurological complications were observed in 48 cases (10.0%), and the accuracy of the DLM was 91.7 ± 3.5%, which was higher than that of the logistic regression (90.1%). Conclusion: A new algorithm using deep learning was able to predict complications after cervical OPLL surgery. This model was well calibrated, with prediction accuracy comparable to that of regression models. The accuracy remained high even for predicting only neurological complications, for which the case number is limited compared to conventional statistical methods.

DOI： 10.1007/s00586-023-07562-2

A semantic segmentation method for laparoscopic images using semantically similar groups

Uramoto L., Hayashi Y., Oda M., Kitasaka T., Misawa K., Mori K.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE 12466 巻 2023年

出版者・発行元：Progress in Biomedical Optics and Imaging - Proceedings of SPIE

In this paper, we present a segmentation method for laparoscopic images using semantically similar groups for multi-class semantic segmentation. Accurate semantic segmentation is a key problem for computer assisted surgeries. Common segmentation models do not explicitly learn similarities between classes. We propose a model that, in addition to learning to segment an image into classes, also learns to segment it into human-defined semantically similar groups. We modify the LinkNet34 architecture by adding a second decoder with an auxiliary task of segmenting the image into these groups. The feature maps of the second decoder are merged into the final decoder. We validate our method against our base model LinkNet34 and a larger LinkNet50. We find that our proposed modification increased the performance both with mean Dice (average +1.5%) and mean Intersection over Union metrics (average +2.8%) on two laparoscopic datasets.

DOI： 10.1117/12.2654636

Improved method for COVID-19 Classification of Complex-Architecture CNN from Chest CT volumes using Orthogonal Ensemble Networks

Toda R., Oda M., Hayashi Y., Otake Y., Hashimoto M., Akashi T., Aoki S., Mori K.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE 12465 巻 2023年

出版者・発行元：Progress in Biomedical Optics and Imaging - Proceedings of SPIE

This paper introduces the improved method for the COVID-19 classification based on computed tomography (CT) volumes using a combination of a complex-architecture convolutional neural network (CNN) and orthogonal ensemble networks (OEN). The novel coronavirus disease reported in 2019 (COVID-19) is still spreading worldwide. Early and accurate diagnosis of COVID-19 is required in such a situation, and the CT scan is an essential examination. Various computer-aided diagnosis (CAD) methods have been developed to assist and accelerate doctors' diagnoses. Although one of the effective methods is ensemble learning, existing methods combine some major models which do not specialize in COVID-19. In this study, we attempted to improve the performance of a CNN for the COVID-19 classification based on chest CT volumes. The CNN model specializes in feature extraction from anisotropic chest CT volumes. We adopt the OEN, an ensemble learning method considering inter-model diversity, to boost its feature extraction ability. For the experiment, We used chest CT volumes of 1283 cases acquired in multiple medical institutions in Japan. The classification result on 257 test cases indicated that the combination could improve the classification performance.

DOI： 10.1117/12.2653792

Classification of COVID-19 cases from chest CT volumes using hybrid model of 3D CNN and 3D MLP-Mixer

Oda M., Zheng T., Hayashi Y., Otake Y., Hashimoto M., Akashi T., Aoki S., Mori K.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE 12465 巻 2023年

出版者・発行元：Progress in Biomedical Optics and Imaging - Proceedings of SPIE

This paper proposes an automated classification method of COVID-19 chest CT volumes using improved 3D MLP-Mixer. Novel coronavirus disease 2019 (COVID-19) spreads over the world, causing a large number of infected patients and deaths. Sudden increase in the number of COVID-19 patients causes a manpower shortage in medical institutions. Computer-aided diagnosis (CAD) system provides quick and quantitative diagnosis results. CAD system for COVID-19 enables efficient diagnosis workflow and contributes to reduce such manpower shortage. In image-based diagnosis of viral pneumonia cases including COVID-19, both local and global image features are important because viral pneumonia cause many ground glass opacities and consolidations in large areas in the lung. This paper proposes an automated classification method of chest CT volumes for COVID-19 diagnosis assistance. MLP-Mixer is a recent method of image classification using Vision Transformer-like architecture. It performs classification using both local and global image features. To classify 3D CT volumes, we developed a hybrid classification model that consists of both a 3D convolutional neural network (CNN) and a 3D version of the MLP-Mixer. Classification accuracy of the proposed method was evaluated using a dataset that contains 1205 CT volumes and obtained 79.5% of classification accuracy. The accuracy was higher than that of conventional 3D CNN models consists of 3D CNN layers and simple MLP layers.

DOI： 10.1117/12.2654706

Real Bronchoscopic Images-based Bronchial Nomenclature: a Preliminary Study

Wang C., Hayashi Y., Oda M., Kitasaka T., Takabatake H., Mori M., Honma H., Natori H., Mori K.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE 12466 巻 2023年

出版者・発行元：Progress in Biomedical Optics and Imaging - Proceedings of SPIE

This article describes a method for bronchial nomenclature using real bronchoscopic (RB) images and pre-built knowledge base of branches. The bronchus has a complex tree-like structure, which increases the difficulty of bronchoscopy. Therefore, a bronchoscopic navigation system is used to help physicians during examination. Conventional navigation system used preoperative CT images and real bronchoscopic images to obtain the camera pose for navigation, whose accuracy is influenced by organ deformation. We propose a bronchial nomenclature method to estimate branch names for bronchoscopic navigation. This method consists of a bronchus knowledge base construction model, a camera motion estimation module, an anatomical structure tracking module, and a branch name estimation module. The knowledge base construction module is used to find the relationship of each branch. The anatomical tracking module is used to track the bronchial orifice (BO) extracted in each RB frame. The camera motion estimation module is used to estimate the camera motion between two frames. The branch name estimation module uses the pre-built bronchus knowledge base and BO tracking results to find the name of each branch. Experimental results showed that it is possible to estimate branch names using only RB images and the pre-built knowledge base of branches.

DOI： 10.1117/12.2654508

Priority attention network with Bayesian learning for fully automatic segmentation of substantia nigra from neuromelanin MRI

Hu Tao, Itoh Hayato, Oda Masahiro, Saiki Shinji, Hattori Nobutaka, Kamagata Koji, Aoki Shigeki, Mori Kensaku

MEDICAL IMAGING 2023 12464 巻 2023年

出版者・発行元：Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Neuromelanin magnetic resonance imaging (NM-MRI) has been widely used in the diagnosis of Parkinson’s disease (PD) for its significantly enhanced contrast between the PD-related structure, the substantia nigra (SN) and surrounding tissues. To develop the computer-aided diagnosis (CAD) system of PD and reduce the labor burden of clinicians, precise and automatic segmentation of SN is becoming more and more desired. This paper proposes a novel network combining the priority gating attention and Bayesian learning for improving the accuracy of fully automatic SN segmentation from NM-MRI. Different from the conventional gated attention model, the proposed network uses the prior SN probability map for guiding the attention computation and reducing the potential disruptions introduced by the background. Additionally, to lower the risks of over-fitting and estimate the confidence scores for the segmentation results, Bayesian learning with Monte Carlo dropout is applied in the training and testing phases. The quantitative results showed that the proposed network acquired the averaged Dice score of 79.46% in comparison with the baseline model 77.93%.

DOI： 10.1117/12.2655112

Octree Cube Constraints in PBD Method for High Resolution Surgical Simulation

Miyazaki Rintaro, Hayashi Yuichiro, Oda Masahiro, Mori Kensaku

MEDICAL IMAGING 2023 12464 巻 2023年

出版者・発行元：Progress in Biomedical Optics and Imaging - Proceedings of SPIE

This paper proposes a deformable tissue model that introduces octree lattice vertex layout and cubic constraints to the orthodox PBD (Position Based Dynamics) method. Surgical simulation is expected to provide a safe method for training in surgery, which is especially useful for preoperative education of inexperienced surgeons and/or for the case a prior attempt is required. To build a surgical simulator, it is necessary to develop organ models with deformations and interaction algorithms between surgical instruments and organ models, all of which must be performed in real time. Since existing surgical simulators focus on real-time performance, the resolution of organ models is limited. The proposed method restricts the vertex locations of the PBD method to the vertices of the octree lattice to save computation time while maintaining a high deformation resolution. To obtain appropriate results even for large deformations, three-dimensional constraints are applied to each octree cube as the constraints of the PBD method. In the simulations, we tested the overall deformation by dropping a liver model and the local deformation scene by laparoscopic clipping. As a result, we achieved deformation simulations at 26.5 fps for the model with approximately 2,672 cube elements and 20,659 vertices.

DOI： 10.1117/12.2654092

L-former : A Lightweight Transformer for Realistic Medical Image Generation and its Application to Super-resolution

Zheng Tong, Oda Hirohisa, Hayashi Yuichiro, Nakamura Shota, Mori Masaki, Takabatake Hirotsugu, Natori Hiroshi, Oda Masahiro, Mori Kensaku

MEDICAL IMAGING 2023 12464 巻 2023年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）出版者・発行元：Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Medical image analysis approaches such as data augmentation and domain adaption need huge amounts of realistic medical images. Generating realistic medical images by machine learning is a feasible approach. We propose L-former, a lightweight Transformer for realistic medical image generation. L-former can generate more reliable and realistic medical images than recent generative adversarial networks (GANs). Meanwhile, L-former does not consume as high computational cost as conventional Transformer-based generative models. L-former uses Transformers to generate low-resolution feature vectors at shallow layers, and uses convolutional neural networks to generate high-resolution realistic medical images at deep layers. Experimental results showed that L-former outperformed conventional GANs by FID scores 33.79 and 76.85 on two datasets, respectively. We further conducted a downstream study by using the images generated by L-former to perform a super-resolution task. A high PSNR score of 27.87 proved L-former’s ability to generate reliable images for super-resolution and showed its potential for applications in medical diagnosis.

DOI： 10.1117/12.2653776

Oesophagus Achalasia Diagnosis from Esophagoscopy Based on a Serial Multi-scale Network 査読有り

Jiang K., Oda M., Hayashi Y., Shiwaku H., Misawa M., Mori K.

Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization 2023年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization

Oesophageal achalasia is a primary oesophageal motility disorder disease. To diagnose oesophagus achalasia, physicians recommend endoscopic evaluation of the oesophagus. However, a low sensitivity still accompanies esophagoscopy on oesophagus achalasia diagnosis. Thus, a quantitative diagnosis system is needed to support physicians diagnose achalasia from the esophagoscopy video. This paper proposes a Serial Multi-scale Network for classifying achalasia images from the esophagoscopy video. The proposed method contains two main components, a Dense-pooling Net, and a Serial Multi-scale Dilated encoder. We construct the Dense-pooling Net using a convolution neural network with dense mixed-pooling connections to extract features. We design the Serial Multi-scale Dilated encoder based on a residual-style dilated encoder. We combine the dilated encoder and spatial attention modules to focus on features we need. We trained and evaluated our method with a dataset that was extracted from several esophagoscopy videos of achalasia patients. The evaluation results reveal a state-of-the-art accuracy of achalasia diagnosis. Furthermore, we developed a real-time computer-aided achalasia diagnosis system with the trained network. In the real-time test, the achalasia diagnosis system can stably output the diagnosis results in only (Formula presented.) seconds. The extended experiments demonstrate that the constructed diagnosis system can diagnose achalasia from esophagoscopy videos.

DOI： 10.1080/21681163.2022.2159534

KST-Mixer: kinematic spatio-temporal data mixer for colon shape estimation 査読有り国際共著

Oda M., Furukawa K., Navab N., Mori K.

Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization 2023年

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization

We propose a spatio-temporal mixing kinematic data estimation method to estimate the shape of the colon with deformations caused by colonoscope insertion. Endoscope tracking or a navigation system that navigates physicians to target positions is needed to reduce such complications as organ perforations. Although many previous methods focused to track bronchoscopes and surgical endoscopes, few number of colonoscope tracking methods were proposed because the colon largely deforms during colonoscope insertion. The deformation causes significant tracking errors. Colon deformation should be considered in the tracking process. We propose a colon shape estimation method using a Kinematic Spatio-Temporal data Mixer (KST-Mixer) that can be used during colonoscope insertions to the colon. Kinematic data of a colonoscope and the colon, including positions and directions of their centerlines, are obtained using electromagnetic and depth sensors. The proposed method separates the data into sub-groups along the spatial and temporal axes. The KST-Mixer extracts kinematic features and mix them along the axes multiple times. We evaluated colon shape estimation accuracies in phantom studies. The proposed method achieved 11.92 mm mean Euclidean distance error, the smallest of the previous methods. Statistical analysis indicated that the proposed method significantly reduced the error compared to the previous methods.

DOI： 10.1080/21681163.2022.2151938

Thrombosis region extraction and quantitative analysis in confocal laser scanning microscopic image sequence in in-vivo imaging

Wu Y., Oda M., Hayashi Y., Kawamura S., Takebe T., Mori K.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE 12468 巻 2023年

出版者・発行元：Progress in Biomedical Optics and Imaging - Proceedings of SPIE

In this paper, we propose a scheme that includes automated extraction of thrombus regions and quantitative analysis of thrombosis in confocal laser scanning microscope (CLSM) blood flow image sequence. Making thrombosis model in animal models play an important role in the development of antithrombotic drugs and ascertaining thrombosis mechanisms. Making thrombosis model in cerebral cortex of mice is usually observed using a CLSM in the fluorescence mode. However, some small changes of thrombus regions are not easily observed in CLSM blood flow image sequences. In addition, it is not easy for researchers to quantitatively analyze the degree of thrombosis. Therefore, we propose a scheme to achieve automatic thrombosis region extraction and quantitative analysis. In which, our thrombosis region extraction method uses analysis of changing pattern of thrombosis regions in CLSM blood flow image sequence. Experimental results showed that our scheme can help biological researchers observe and analyze the changes of thrombosis in animal models and reduced the use of fluorescent thrombus markers.

DOI： 10.1117/12.2654632

TriMix: A General Framework for Medical Image Segmentation from Limited Supervision

Zheng Z., Hayashi Y., Oda M., Kitasaka T., Mori K.

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 13846 LNCS 巻頁： 185 - 202 2023年

出版者・発行元：Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

We present a general framework for medical image segmentation from limited supervision, reducing the reliance on fully and densely labeled data. Our method is simple, jointly trains triple diverse models, and adopts a mix augmentation scheme, and thus is called TriMix. TriMix imposes consistency under a more challenging perturbation, i.e., combining data augmentation and model diversity on the tri-training framework. This straightforward strategy enables TriMix to serve as a strong and general learner learning from limited supervision using different kinds of imperfect labels. We conduct extensive experiments to show TriMix’s generic purpose for semi- and weakly-supervised segmentation tasks. Compared to task-specific state-of-the-arts, TriMix achieves competitive performance and sometimes surpasses them by a large margin. The code is available at https://github.com/MoriLabNU/TriMix.

DOI： 10.1007/978-3-031-26351-4_12

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