Faculty Profiles - ISHIKAWA, Tetsuya

Papers - ISHIKAWA, Tetsuya

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Expression of glypican-3 (GPC 3) and its significance as a novel marker of the degree of dedifferentiation in hepatocellular carcinoma

Fukuzawa Y, Furuta K, Tagaya T, Sato K, Maeno T, Ayada M, Hotta N, Okumura A, Ishikawa T, Kakumu S

HEPATOLOGY Vol. 36 ( 4 ) page： 691A - 691A 2002.10

Different distribution of antigenic B cell and T cell epitopes within HBV core region

Okumura A, Ishikawa T, Sato K, Maeno T, Ayada M, Hotta N, Tagaya T, Fukuzawa Y, Kakumu S

HEPATOLOGY Vol. 36 ( 4 ) page： 620A - 620A 2002.10

慢性肝疾患と免疫 B型慢性肝炎患者におけるHBc抗原領域のエピトープの同定とそれに対する免疫応答の質的解析

石川哲也, 田邊純一, 佐藤顕, 前野禎, 綾田穣, 堀田直樹, 多賀谷恒明, 奥村明彦, 福沢嘉孝, 各務伸一

消化器と免疫 ( 38 ) page： 20 - 23 2002.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本消化器免疫学会

B型慢性肝炎患者(B-CH)におけるHBc抗原特異的免疫応答の標的部位の解析,免疫応答の質的評価を行った.B-CH患者23例を対象に,HBc抗原領域をカバーする13〜15merのペプタイドを作製し,患者末梢血単核球を刺激後,細胞内サイトカイン/ケモカイン発現パターンをflow cytometry(FACS)及びRT-PCRにて解析した.FACS解析では,HBc91-105(p19)での刺激時に,FN-γ+細胞,IL-4+細胞とも有意な増加がみられた.また,RT-PCRを用いた解析ではp19による刺激で11例中8例で,多くの場合,同時に複数のサイトカイン/ケモカインの発現増強がみられた.これらのことから,B-CH患者においてはp19に主要なエピトープが存在している可能性が示唆された

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Expression of Fas/Fas ligand (FasL) and its involvement in infiltrating lymphocytes in hepatocellular carcinoma (HCC)

FUKUZAWA Yoshitaka, TAKAHASHI Kiyoshi, FURUTA Keiko, TAGAYA Tsuneaki, ISHIKAWA Tetsuya, WADA Kaori, OMOTO Yasukazu, KOJI Takehiko, KAKUMU Shinichi

Journal of gastroenterology Vol. 36 ( 10 ) page： 681 - 688 2001.10

Expression of Fas/Fas ligand (FasL) and its involvement in infiltrating lymphocytes in hepatocellular carcinoma (HCC). Reviewed

Fukuzawa Y, Takahashi K, Furuta K, Tagaya T, Ishikawa T, Wada K, Omoto Y, Koji T, Kakumu S.

J Gastroenterol Vol. 36 ( 10 ) page： 178-186 2001.10

Expression of Fas/Fas ligand (FasL) and its involvement in infiltrating lymphocytes in hepatocellular carcinoma (HCC) Reviewed

Y Fukuzawa, K Takahashi, K Furuta, T Tagaya, T Ishikawa, K Wada, Y Omoto, T Koji, S Kakumu

JOURNAL OF GASTROENTEROLOGY Vol. 36 ( 10 ) page： 681 - 688 2001.10

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER-VERLAG

Background. This study was conducted to examine the expression of Fas/Fas ligand (FasL), to elucidate its relationship with tumor-infiltrating lymphocytes (TILs), and to detect possible gene mutation of Fas/FasL in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). Methods. Indirect immunohistochemical staining was performed on formalin-fixed, paraffin-embedded sections of liver biopsy and surgery specimens from five normal livers, and from the livers of 30 patients with HCC. Fas/FasL mRNA-expressing cells and apoptotic cells were detected by in situ hybridization and DNA nick end labeling (TUNEL), respectively. We also performed polymerase chain reaction (PCR) -amplifying and direct sequencing for the Fas/FasL gene. Results. Fas/FasL and its mRNA were localized on the, membrane or in the cytoplasm in some HCC cells, as well as hepatocytes. Their expression was enhanced in areas with infiltrating inflammatory cells in the noncancerous regions of liver tissue and on the margins of the cancerous tissue. The positivity rate for TUNEL was elevated along these margins. The labeling index of Fas/FasL was lower in the cancerous liver tissue than in the surrounding noncancerous region (P < 0.01), and tended to decrease in proportion to the malignancy of tumor cells; Fas/FasL expression was not found on poorly differentiated type cancer cells. Fas(-)/FasL(+), FasL-mRNA(+) HCC cells were seen in one specimen of moderately differentiated type. Some CD8+T lymphocytes were TUNEL-positive around the cancerous region. In this study, cancerous and noncancerous tissues in HCC revealed no genetic mutations in any exons of Fas/FasL. Conclusions. These findings suggest that Fas/FasL expression was decreased in proportion to the malignancy of tumor cells, and that infiltrating CD8+T lymphocytes play a role in apoptosis in HCC. The apoptosis in HCC could be regulated by the suppression of Fas/FasL expression, or, sometimes, by the enhancement of FasL expression.

DOI： 10.1007/s005350170031

Web of Science

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Expression of Fas/Fas ligand (FasL) and its involvement in infiltrating lymphocytes in hepatocellular carcinoma (HCC)

Fukuzawa Y, Takahashi K, Furuta K, Tagaya T, Ishikawa T, Wada K, Omoto Y, Koji T, Kakumu S

JOURNAL OF GASTROENTEROLOGY Vol. 36 ( 10 ) page： 681 - 688 2001.10

Identification of highly immunogenic T cell epitope within HBV core region and immune response triggered by the activation of HBV core specific T cells.

Ishikawa T, Tanabe J, Okumura A, Maeno T, Yamamoto K, Hotta N, Yoshida K, Ito M, Tagaya T, Fukuzawa Y, Kakumu S

HEPATOLOGY Vol. 34 ( 4 ) page： 312A - 312A 2001.10

Crosstalk between oxidative stress and apoptosis in hepatocellular carcinoma (HCC).

Fukuzawa Y, Hotta N, Furuta K, Maeno T, Yamamoto K, Yoshida K, Ito M, Tagaya T, Okumura A, Ishikawa T, Kakumu S

HEPATOLOGY Vol. 34 ( 4 ) page： 515A - 515A 2001.10

Experimental autoimmune hepatitis in mice following immunization with cytochrome P450IID6.

Ishikawa T, Tanabe JC, Okumura A, Ito M, Maeno T, Yamamoto K, Yoshida K, Hotta N, Tagaya T, Fukuzawa Y, Miyakawa H, Kakumu S

HEPATOLOGY Vol. 34 ( 4 ) page： 286A - 286A 2001.10

Increased insulin resistance in the patients with chronic HCV infection is mediated by elevated serum TNF alpha.

Maeno T, Okumura A, Ishikawa T, Yamamoto K, Hotta N, Yoshida K, Ito M, Tagaya T, Fukuzawa Y, Kakumu S

HEPATOLOGY Vol. 34 ( 4 ) page： 552A - 552A 2001.10

Impaired function of peripheral blood dendritic cell subsets of hepatitis C virus-infected patients.

Sobue S, Nomura T, Nakao H, Okumura A, Ishikawa T, Kakumu S, Itoh M

HEPATOLOGY Vol. 34 ( 4 ) page： 482A - 482A 2001.10

Th1/Th2 cytokine profiles and their relationship to clinical features in patients with chronic hepatitis C virus infection. Reviewed

Sobue S, Nomura T, Ishikawa T, Ito S, Saso K, Ohara H, Joh T, Itoh M, Kakumu S.

J Gastroenterol Vol. 36 ( 8 ) page： 544-551 2001.8

消化器疾患の病態とTh1/Th2バランス肝細胞のケモカイン産生とTh1/Th2バランスへの影響

石川哲也, 田邊純一, 伊東正道, 奥村明彦, 多賀谷恒明, 福澤嘉孝, 各務伸一

消化器と免疫 ( 37 ) page： 5 - 8 2001.7

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本消化器免疫学会

肝細胞の炎症及びTh1/Th2 cytokine刺激に対する反応,その後のTh1/Th2バランスに与える影響を,肝細胞のchemokine産生を測定することにより検討した.肝細胞はIFN-γ(Th1)刺激により,更にTh1反応を促進する方向に働くこと,IL-4(Th2)刺激によりTh1反応を抑制し,Th2反応を間接的に促進する方向に働くことがわかった.IL-1O(Th2)刺激はTh2反応を間接的に促進する方向に働いた.肝炎においては肝細胞自身が免疫応答の方向性を制御している可能性が示された

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Apoptosis is induced by caspase activation and cytochrome c release in photodynamic therapy (PDT) of human hepatocellular carcinoma cells.

Okumura A, Hamblin MR, Hasan T, Ishikawa T, Kakumu S, Takahashi H

GASTROENTEROLOGY Vol. 120 ( 5 ) page： A363 - A363 2001.4

最近の癌の動向当科における肝癌患者の実態

福沢嘉孝, 堀田直樹, 前野禎, 山本賢一, 吉田香果, 吉田篤生, 伊東正道, 多賀谷恒明, 奥村明彦, 石川哲也

愛知医科大学医学会雑誌 Vol. 29 ( 2 ) page： 148 - 150 2001.3

Mutation at codon 130 in hepatitis B virus (HBV) core region increases markedly during acute exacerbation of hepatitis in chronic HBV carriers. Reviewed

Okumura A, Ishikawa T, Yoshioka K, Yuasa R, Fukuzawa Y, Kakumu S.

J Gastroenterol Vol. 36 ( 2 ) page： 103-110 2001.2

Update of liver disease related to chronic hepatitis B virus infection. Invited

Ishikawa T, Kakumu S.

Int Med Vol. 40 ( 2 ) page： 178-179 2001.2

Symposium on Clinical Aspects in Hepatitis Virus Infection, Update of Liver Disease Related to Chronic Hepatitis B Virus Infection

ISHIKAWA Tetsuya, KAKUMU Shinichi

Internal medicine Vol. 40 ( 2 ) page： 178 - 179 2001.2

学会記”肝臓学会” Reviewed

各務伸一, 福沢嘉孝, 石川哲也, 奥村明彦

日本醫亊新報 ( 4033 ) page： 40 - 42 2001

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Papers - ISHIKAWA, Tetsuya