Faculty Profiles - ISHIKAWA, Tetsuya

Papers - ISHIKAWA, Tetsuya

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V alpha14 NKT cells activated by alpha-galactosylceramide augment lipopolysaccharide-induced nitric oxide production in mouse intra-hepatic lymphocytes. Reviewed

Ohtaki H, Ito H, Ando K, Ishikawa T, Saito K, Imawari M, Yokochi T, Moriwaki H, Seishima M

Biochem Biophys Res Com Vol. 378 ( 3 ) page： 579-583 2009.1

Role of TNF-alpha produced by nonantigen-specific cells in a fulminant hepatitis mouse model. Reviewed

Ito H, Ando K, Ishikawa T, Saito K, Takemura M, Imawari M, Moriwaki H, Seishima M.

J Immunol Vol. 182 ( 1 ) page： 391-397 2009.1

Usefulness of radiofrequency ablation with micro-convex probe for hepatocellular carcinoma. Reviewed

HOTTA Naoki, AYADA Minoru, MATSUMOTO Eiji, OKUMURA Akihiko, ISHIKAWA Tetsuya, SATO Ken, OOHASHI Tomohiko, KAKUMU Shinichi

Hepato-gastroenterology Vol. 56 ( 93 ) page： 1127-1132 2009

Language：English Publishing type：Research paper (scientific journal)

Background/Aims: It was aimed to assess whether a micro-convex probe is superior to the present conventional probe for ultrasonography from the points of safety and efficacy during percutaneous radiofrequency ablation therapy for hepatocellular carcinoma. Methodology: Twenty-one patients with 23 hepatocellular carcinoma lesions who had one or 2 lesions, each 4 cm or less in diameter, and liver function of Child-Pugh class A or B were enrolled. All the patients except for 2 patients were seropositive for hepatitis C virus. Radiofrequency ablation was carried out under a real-time US guidance. The cooled-tip electrodes used were single and clustered. Results: It was possible to perform safe and accurate percutaneous radiofrequency ablation procedure using micro-convex probes for the treatment of all hepatocellular carcinoma nodules. It was also possible to treat hepatocellular carcinoma located in the right subphrenic region without artificial pleural effusion under intercostal ultrasonography guide. Improved clustered needles were successfully applied to treat the nodules more than 3 cm in diameter with less resistance for penetration compared with the conventional needle. The findings of advanced dynamic flow image on ultrasonography to assess the therapeutic efficacy indicated the consistency with those of dynamic CT which was done 3 to 5 days later radiofrequency ablation. Major complication of radiofrequency ablation procedure was noted in none. Conclusions: These results suggest that micro-convex probe with clustered tips is superior to conventional probe for ultrasonography from the points of safety and efficacy during radiofrequency ablation for hepatocellular carcinoma nodule located in the right subphrenic region and for larger sized nodule more than 3 cm.

A patient with Gilbert's syndrome complicated with drug-induced liver injury by the over-the-counter drug and Fluvastatin Sodium: A case report Reviewed

Minoru Ayada, Tetsuya Ishikawa, Akihiko Okumura, Naoki Hotta, Akinori Hirose, Kazuo Masuko, Shinichi Kakumu

Acta Hepatologica Japonica Vol. 50 ( 3 ) page： 139 - 144 2009

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Hepatology

A 56-year-old female was admitted to our hospital because of epigastralgia, vomiting, hyperbilirubinemia, and abnormalities in the hepatic function tests. After the discontinuation of an over-the-counter drug, her symptoms and the abnormalities in the blood tests were improved. Thus she was diagnosed as drug-induced liver injury by the over-the-counter drug. The second episode of drug-induced liver injury occurred when she took Fluvastatin Sodium for her hyperlipemia. The liver injury was improved by the discontinuation of the drug
however, only serum indirect bilirubin level remained abnormal. She was suspected to have constitutional jaundice, and diagnosed as Gilbert's syndrome by the analysis of gene polymorphism for UDP-glucuronyl transferase (UGT1A1). The polymorphism of UGT1A1 affects the efficiency of the lipophilic drug metabolism, and the activity of UGT1A1 is known to be low in the patients with Gilbert's syndrome Therefore the present case suggests that the recurrent drug-induced liver injury might be related to the low UGT1A1 activity due to Gilbert's syndrome. We here report the case with Gilbert's syndrome complicated with the recurrent drug-induced liver injuries. © 2009 The Japan Society of Hepatology.

DOI： 10.2957/kanzo.50.139

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Deficiency of forkhead box P3 and cytotoxic T-lymphocyte-associated antigen-4 gene expressions and impaired suppressor function of CD4+CD25+ T cells in patients with autoimmune hepatitis

OKUMURA Akihiko, ISHIKAWA Tetsuya, SATO Sayaka, YAMAUCHI Taeko, OSHIMA Hisae, OHASHI Tomohiko, SATO Ken, AYADA Minoru, HOTTA Naoki, KAKUMU Shinichi

Hepatology research : the official journal of the Japan Society of Hepatology Vol. 38 ( 9 ) page： 896 - 903 2008.9

Deficiency of forkhead box P3 and cytotoxic T-lymphocyte-associated antigen-4 gene expressions and impaired suppressor function of CD4+CD25+ T cells in patients with autoimmune hepatitis. Reviewed

Okumura A, Ishikawa T, Sato S, Yamauchi T, Oshima H, Ohashi T, Sato K, Ayada M, Hotta N, Kakumu S.

Hepatol Res Vol. 38 ( 9 ) page： 896-903 2008.9

Role of V alpha14+ NKT cells in the development of hepatitis B virus-specific CTL: Activation of V alpha14+ NKT cells promotes the breakage of CTL tolerance. Reviewed

Ito H, Ando K, Ishikawa T, Nakayama T, Taniguchi M, Saito K, Imawari M, Moriwaki H, Yokochi T, Kakumu S, Seishima M.

Int Immunol Vol. 20 ( 7 ) page： 869-879 2008.7

Use of the Model for End-Stage Liver Disease (MELD) score to predict 1-year survival of Japanese patients with cirrhosis and to determine who will benefit from living donor liver transplantation. Reviewed

Ishigami M, Honda T, Okumura A, Ishikawa T, Kobayashi M, Katano Y, Fujimoto Y, Kiuchi T, Goto H.

J Gastroenterol Vol. 43 ( 5 ) page： 363-368 2008.5

Upregulation of indoleamine 2,3-dioxygenase in hepatocyte during acute hepatitis caused by hepatitis B virus-specific cytotoxic T lymphocytes in vivo. Reviewed

Iwamoto N, Ito H, Ando K, Ishikawa T, Hara A, Taguchi A, Saito K, Takemura M, Imawari M, Moriwaki H, Seishima M.

Liv Int Vol. 29 ( 2 ) page： 277-283 2008.2

Use of hepatitis B vaccine for the treatment of chronic hepatitis B

ISHIKAWA Tetsuya, KAKUMU Shinichi

Hepatology research : the official journal of the Japan Society of Hepatology Vol. 37 page： S347 - S350 2007.10

B型肝炎の新たな治療展開 B型肝炎の治療戦略　Adefovir pivoxil

石川哲也, 各務伸一

内科 Vol. 100 ( 4 ) page： 677 - 682 2007.10

Expression of Toll-like receptors in chronic hepatitis C virus infection. Reviewed

Sato K, Ishikawa T, Okumura A, Yamauchi T, Sato S, Ayada M, Matsumoto E, Hotta N, Ohashi T, Fukuzawa Y, Kakumu S.

J Gastroenterol Hepatol Vol. 22 ( 10 ) page： 1627-1632 2007.10

Use of HB vaccine for the treatment of chronic hepatitis B. Invited

Ishikawa T, Kakumu S.

Hepatol Res Vol. 37 ( S3 ) page： S347-S350 2007.10

Effect of Vitamin K2 on the recurrence in patients with hepatocellular carcinoma. Reviewed

Hotta N, Ayada M, Sato K, Ishikawa T, Okumura A, Matsumoto E, Ohashi T, Kakumu S.

Hepato-gastroenterology Vol. 54 ( 79 ) page： 2073-2077 2007.10

今月の主題消化器薬の使い方Update 消化器疾患の薬物治療自己免疫性肝炎(AIH)

石川哲也

medicina Vol. 44 ( 9 ) page： 1713 - 1715 2007.9

Double filtration plasmapheresis and interferon combination therapy for chronic hepatitis C patients with genotype 1 and high viral load

FUJIWARA Kenji, KANEKO Shuichi, KAKUMU Shinichi, SATA Michio, HIGE Shuhei, TOMITA Eiichi, MOCHIDA Satoshi, IDE T., NISHIDA H., YOKOYAMA H., YAMASHITA T., MORIWAKI H., NAGAKI M., SUGIHARA J., TAKAHASHI H., ISHIKAWA T., MIYATA M., NISHIKAWA K., NAGOSHI S., SUGAHARA S., YAMAMOTO K., MIZUTA T., ANDO T., TAKEI Y., ENOMOTO N., TSUDA H., SUMINO Y., ISHII K., SAISHO H., YOKOSUKA O., EGUCHI K., HAMASAKI K., SAWADA K., FUKUNAGA K., ARAKAWA Y., MORIYAMA M., IMAWARI M., ITO T.

Hepatology research : the official journal of the Japan Society of Hepatology Vol. 37 ( 9 ) page： 701 - 710 2007.9

Combination therapy with lamivudine and HB vaccine on chronic hepatitis B

ISHIKAWA Tetsuya, KAKUMU Shinichi

Hepatology research : the official journal of the Japan Society of Hepatology Vol. 37 page： S62 - S66 2007.7

Combination thearpy with lamivudine and HB vaccine on chronic heaptitis B. Invited

Ishikawa T, Kakumu S.

Hepatol Res Vol. 37 ( S1 ) page： S62-S66 2007.7

今月の主題ウイルス肝炎実地診療A to Z 扉

石川哲也

medicina Vol. 44 ( 5 ) page： 847 - 847 2007.5

今月の主題ウイルス肝炎実地診療A to Z 座談会外来で診るウイルス肝炎-効果的な病診連携のために

八橋弘, 伊東和樹, 柴田実, 石川哲也

medicina Vol. 44 ( 5 ) page： 972 - 983 2007.5

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Papers - ISHIKAWA, Tetsuya