Faculty Profiles - ISHIKAWA, Tetsuya

Papers - ISHIKAWA, Tetsuya

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今月の主題ウイルス肝炎実地診療A to Z ウイルス肝炎の的確な診断のために肝障害患者の診断の進め方

各務伸一, 石川哲也

medicina Vol. 44 ( 5 ) page： 848 - 851 2007.5

Usefulness of a Bloodflow Diagnosis at Liver Tumors Using Sonazoid

AYADA Minoru, HOTTA Naoki, OKUMURA Akihiko, ISHIKAWA Tetsuya, KIBA Kumiko, KURODA Yasuko, NIWA Sachiyo, IDO Makoto, KAKUMU Sinichi

Vol. 34 2007.4

Four-Dimensional Ultrasonography for Therapeutic Radiofrequency Ablation for Hepatocellular Carcinoma

HOTTA Naoki, AYADA Minoru, HIJIKATA Yasutaka, OOHASHI Tomohiko, SATO Ken, OKUMURA Akihiko, ISHIKAWA Tetsuya, OONO Nagayuki, KAKUMU Shinichi

Vol. 34 2007.4

Usefulness of ultrasonography to Liver Tumor in Live 3D

HOTTA Naoki, AYADA Minoru, OOHASHI Tomohiko, SATO Ken, OKUMURA Akihiko, ISHIKAWA Tetsuya, KOSAKI Masahiro, KAKUMU Shinichi

Vol. 34 2007.4

Effect of vitamin K2 on the recurrence in patients with hepatocellular carcinoma

Hotta Naoki, Ayada Minoru, Sato Ken, Ishikawa Tetsuya, Ohumura Ahihiko, Matsumoto Eiji, Ohashi Tomohiko, Kakumu Shinichi

HEPATO-GASTROENTEROLOGY Vol. 54 ( 79 ) page： 2073 - 2077 2007

Management of imatinib mesilate (IM)-related hepatic injury by adjusting the dose of the drug in a patient with chronic myelogenous leukemia (CML): A case report

Ayada Minoru, Ishikawa Tetsuya, Okumura Akihiko, Hotta Naoki, Furuta Keiko, Yamauchi Taeko, Hijikata Yasutaka, Ohashi Tomohiko, Sato Ken, Kakumu Shinichi

Kanzo Vol. 48 ( 10 ) page： 505 - 510 2007

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Hepatology

A 72-year-old female, with chronic myelogenous leukemia (CML) treated successfully with 400mg/day of imatinib mesilate (IM), developed laboratory signs of a cholestatic type of liver injury after one-year administration of IM, and was admitted to our hospital. We decided to stop the administration of IM to the patient. Thereafter the abnormalities in liver function tests recovered to the normal level promptly. However, with a necessity to use IM for preventing the recurrence of CML, we re-started administration of IM at a lower dose, by weighing the risk for liver injury and the benefit for CML in a balance. With careful monitoring of liver function tests, the dose of IM was gradually increased and reached 300mg/d, and the recurrence of liver injury or CML has not been observed. Here, we report the case of IM-related liver injury, controlled well after the re-administration of IM with the lower dose.<br>

DOI： 10.2957/kanzo.48.505

CiNii Research

Combination therapy with lamvudine and HB vaccine on chronic hepatitis B.

石川哲也

Hepatology Research 37 2007

A CASE OF HEMORRHAGIC GASTRIC VASCULAR ECTASIA TO BE ACCOMPANIED BY IDIOPATHIC PULMONARY FIBROSIS : SUCCESSFULLY TREATED BY ENDOSCOPIC BAND LIGATION

AYADA Minoru, NAKANO Tatsunori, HOTTA Naoki, OKUMURA Akihiko, ISHIKAWA Tetsuya, OHASHI Tomohiko, MATSUMOTO Eiji, SATO Ken, YOSIDA Kagumi, KAKUMU Shinichi

Gastroenterol Endosc Vol. 48 ( 11 ) page： 2626 - 2631 2006.11

Role of toll-like receptors in hepatitis C virus-infected chronic liver disease

Kakumu Shinichi, Okumura Akihiko, Ishikawa Tetsuya, Yamauchi Taeko, Sato Sayaka, Sato Ken, Ohashi Tomohiko, Ayada Minoru, Hotta Naoki, Fukuzawa Yoshitaka

HEPATOLOGY Vol. 44 ( 4 ) page： 300A - 300A 2006.10

Efficacy of non-invasive hepatic fibrosis quantificated-evaluation by liver elasticity measurement in nonalcoholic steatohepatitis (NASH) - Comparison of ultrasonic transient elastography and histopathological diagnosis

Fukuzawa Yoshitaka, Kizawa Senji, Ohashi Tomohiko, Matsumoto Eiji, Sato Ken, Ayada Minoru, Hotta Naoki, Okumura Akihiko, Ishikawa Tetsuya, Kakumu Shinichi

HEPATOLOGY Vol. 44 ( 4 ) page： 649A - 650A 2006.10

Expression of toll-like receptor family on regulatory T cells in the patients with autoimmune hepatitis

Okumura Akihiko, Ishikawa Tetsuya, Sato Sayaka, Yamauchi Taeko, Ohashi Tomohiko, Sato Ken, Ayada Minoru, Hotta Naoki, Fukuzawa Yoshitaka, Kakumu Shinichi

HEPATOLOGY Vol. 44 ( 4 ) page： 640A - 641A 2006.10

Four-dimensional ultrasonography for therapeutic radiofrequency ablation for heaptocellular carcinoma. Reviewed

Hotta N, Maeno T, Ayada M, Sato K, Ishikawa T, Okumura A, Matsumoto E, Fukuzawa Y, Kakumu S.

Hepato-gastroenterology Vol. 53 ( 70 ) page： 521-525 2006.7

TRIALS OF PERCUTANEOUS ENDOSCOPIC GASTROSTOMY BY TRANSNASAL ENDOSCOPY USING A SMALL-CALIBER ENDOSCOPE

AYADA Minoru, NAKANO Tatsunori, HOTTA Naoki, NAKAE Harumichi, KUNII Shin, YOSHIDA Kagumi, OKUMURA Akihiko, ISHIKAWA Tetsuya, FUKUZAWA Yoshitaka, KAKUMU Shinichi

GASTROENTEROLOGICAL ENDOSCOPY Vol. 48 ( 7 ) page： 1425 - 1430 2006.7

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Gastroenterological Endoscopy Society

We performed percutaneous endoscopic gastrostomy (PEG) by transnasal endoscopy using a small-caliber endoscope for the purpose of relieving the pain and stress of gastrointestinal endoscopy and PEG without conscious cedation. The usefulness and safety were compared between cases performed PEG by transnasal endoscopy and those by transoral endoscopy. Cases with dysphagia by neurological diseases were divided into two groups randomly. The pull technique was used for both groups. We observed vital signs etc to compare pain and stress in transnasal insertion group and transoral insertion group. An increase in blood pressure and pulse rate was significantly small during PEG in the transnasal insertion group compared to the transoral group. There was no major complication in the transnasal insertion group as well as the transoral group. Our experience suggested that PEG by transnasal endoscopy using a smallcaliber endoscope is more useful than PEG by transoral endoscopy to relieve the pain and stress, and PEG by transnasal endoscopy is a safe method as well as PEG by transoral endoscopy.

DOI： 10.11280/gee1973b.48.1425

CiNii Research

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Alteration of serum cytokine balances among different phases of chronic hepatitis B virus infection. Reviewed

Ayada M, Ishikawa T, Okumura A, Tanabe J, Ito H, Ohashi T, Matsumoto E, Sato K, Hotta N, Fukuzawa Y, Kakumu S.

Hepatol Res Vol. 34 ( 4 ) page： 214-221 2006.4

慢性肝疾患の病態にせまる免疫学的アプローチ自己免疫性肝炎(AIH)における制御性T細胞(Tr)の機能低下

奥村明彦, 石川哲也, 伊藤弘康, 佐藤さやか, 山内妙子, 大橋知彦, 松本英司, 佐藤顕, 綾田穣, 堀田直樹, 福澤嘉孝, 各務伸一

消化器と免疫 Vol. 42 ( 42 ) page： 29 - 32 2006.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本消化器免疫学会

自己免疫性肝炎患者の制御性T細胞(Tr)について,Trの機能を調節しているFoxp3,TNF-R-SF18,CTLA-4,CD28の各遺伝子の発現を調べ調べ,自己免疫性肝炎(AIH)患者と健常者のTrのサイトカイン産生能を比較し,TrがAIHの病態に関与している可能性について検討した.AIH 15例,コントロールとしてC型慢性肝炎(CH-C)患者26例と健常人12例を対象とした.AIHではFoxp3,CTLA-4のmRNA量が減少し,TrによるIL-10の産生能が低下していることが明らかとなった.Trの機能異常が病態に関与している可能性が示唆された

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Plasma amino acid profiles applied for diagnosis of advanced liver fibrosis in patients with chronic hepatitis C infection. Reviewed

Zhang Q, Takahashi M, Noguchi Y, Sugimoto T, Kimura T, Okumura A, Ishikawa T, Kakumu S.

Hepatol Res Vol. 34 ( 3 ) page： 170-177 2006.3

The SHAP-hyaluronan complex in serum from patients with chronic liver diseases caused by hepatitis virus infection. Reviewed

Shen L, Zhuo L, Okumura A, Ishikawa T, Miyachi M, Owa Y, Ishizawa T, Sugiura N, Nagata Y, Nonami T, Kakumu S, Kimata K.

Hepatol Res Vol. 34 ( 3 ) page： 178-186 2006.3

肝癌局所療法における超音波ドプラ法の新展開 Real Time 4D Ultrasoundを用いた肝細胞癌のラジオ波焼灼療法の有用性-マイクロコンベックスプローブ使用における検討も含めて

堀田直樹, 大橋知彦, 松本英司, 佐藤顕, 綾田穣, 奥村明彦, 石川哲也, 福沢嘉孝, 各務伸一

Rad Fan Vol. 4 ( 3 ) page： 116 - 119 2006.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(株)メディカルアイ

従来の2D modeのエコーではなく,Real Time 4D Ultrasound systemsを用いて肝細胞癌に対しラジオ波焼灼療法(RFA)を施行し,その有用性について検討した.また,マイクロコンベックスプローブにおいても検討した.肝細胞癌22例25結節を対象とした.RFA施行22例25結節において,全症例Real Time 4D Ultrasound systemにて穿刺可能であった.Real Time 4D Ultrasound使用によるRFAは多方向より針の留置部位を確認することができ,より正確に経皮的治療を施行することができた

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Cholestatic hepatic injury related to administration of sodium risedronate hydrate. A case report with distinctive histological findings

AYADA Minoru, ISHIKAWA Tetsuya, OKUMURA Akihiko, OHASHI Tomohiko, MATSUMOTO Eiji, SATO Ken, HOTTA Naoki, FUKUZAWA Yoshitaka, KAKUMU Shinichi

Kanzo Vol. 47 ( 1 ) page： 10 - 15 2006.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Hepatology

A 53-year-old woman was hospitalized because of general fatigue, jaundice, and the elevation of serum hepatic and biliary enzymes. She was suffering from osteoporosis, and had undergone treatment with oral administration of sodium risedronate hydrate (SRH) for 6 months before admission. Liver injury related to SRH was suspected, and the medication was stopped. After cessation of the medication, she recovered from her illness, and the elevated enzymes gradually declined. According to the diagnostic scale for drug-induced hepatic injury at the workshop in Digestive Disease Week-Japan 2004, her liver injury was classified into cholestatic type and judged “highly possible.” Liver biopsy showed the distinctive findings, such as diffuse rosette formations of hepatocytes in liver parenchyma, and strongly supported the diagnosis.<br>Liver biopsy gives us important, sometimes critical information as the present case, thus it should be considered for execution as an auxiliary measure for accurate diagnosis of drug-related liver injury.

DOI： 10.2957/kanzo.47.10

CiNii Research

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Four-dimensional ultrasonography for therapeutic radiofrequency ablation for hepatocellular carcinoma

Hotta Naoki, Maeno Tadashi, Ayada Minoru, Sato Ken, Ishikawa Tetsuya, Okumura Akihiko, Matsumoto Eiji, Fukuzawa Yoshitaka, Kakumu Shinichi

HEPATO-GASTROENTEROLOGY Vol. 53 ( 70 ) page： 521 - 525 2006

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Papers - ISHIKAWA, Tetsuya