研究者詳細 - 石川　哲也

論文 - 石川　哲也

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V alpha14 NKT cells activated by alpha-galactosylceramide augment lipopolysaccharide-induced nitric oxide production in mouse intra-hepatic lymphocytes. 査読有り

Ohtaki H, Ito H, Ando K, Ishikawa T, Saito K, Imawari M, Yokochi T, Moriwaki H, Seishima M

Biochem Biophys Res Com 378 巻 ( 3 ) 頁： 579-583 2009年1月

Role of TNF-alpha produced by nonantigen-specific cells in a fulminant hepatitis mouse model. 査読有り

Ito H, Ando K, Ishikawa T, Saito K, Takemura M, Imawari M, Moriwaki H, Seishima M.

J Immunol 182 巻 ( 1 ) 頁： 391-397 2009年1月

Usefulness of radiofrequency ablation with micro-convex probe for hepatocellular carcinoma. 査読有り

HOTTA Naoki, AYADA Minoru, MATSUMOTO Eiji, OKUMURA Akihiko, ISHIKAWA Tetsuya, SATO Ken, OOHASHI Tomohiko, KAKUMU Shinichi

Hepato-gastroenterology 56 巻 ( 93 ) 頁： 1127-1132 2009年

記述言語：英語掲載種別：研究論文（学術雑誌）

Background/Aims: It was aimed to assess whether a micro-convex probe is superior to the present conventional probe for ultrasonography from the points of safety and efficacy during percutaneous radiofrequency ablation therapy for hepatocellular carcinoma. Methodology: Twenty-one patients with 23 hepatocellular carcinoma lesions who had one or 2 lesions, each 4 cm or less in diameter, and liver function of Child-Pugh class A or B were enrolled. All the patients except for 2 patients were seropositive for hepatitis C virus. Radiofrequency ablation was carried out under a real-time US guidance. The cooled-tip electrodes used were single and clustered. Results: It was possible to perform safe and accurate percutaneous radiofrequency ablation procedure using micro-convex probes for the treatment of all hepatocellular carcinoma nodules. It was also possible to treat hepatocellular carcinoma located in the right subphrenic region without artificial pleural effusion under intercostal ultrasonography guide. Improved clustered needles were successfully applied to treat the nodules more than 3 cm in diameter with less resistance for penetration compared with the conventional needle. The findings of advanced dynamic flow image on ultrasonography to assess the therapeutic efficacy indicated the consistency with those of dynamic CT which was done 3 to 5 days later radiofrequency ablation. Major complication of radiofrequency ablation procedure was noted in none. Conclusions: These results suggest that micro-convex probe with clustered tips is superior to conventional probe for ultrasonography from the points of safety and efficacy during radiofrequency ablation for hepatocellular carcinoma nodule located in the right subphrenic region and for larger sized nodule more than 3 cm.

市販薬およびフルバスタチンナトリウムによる薬物性肝障害を発症したＧｉｌｂｅｒｔ症候群の１例査読有り

綾田穣, 石川哲也, 奥村明彦, 堀田直樹, 広瀬昭憲, 増子和郎, 各務伸一

肝臓 50 巻 ( 3 ) 頁： 139 - 144 2009年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人　日本肝臓学会

症例は，56歳女性．心窩部痛と嘔吐に対し市販薬を内服するも改善せず，外来を受診．黄疸，肝胆道系酵素の上昇を認めたため入院となった．市販薬による薬物性肝障害を疑い，内服を中止．肝障害は軽快した．退院後，高脂血症に対しフルバスタチンナトリウムを投与したところ再び肝障害が出現した．内服中止により，肝障害は改善したが，以後も持続する間接ビリルビン優位の高ビリルビン血症を認めた．Gilbert症候群を疑い，遺伝子解析により同症候群と確定診断した．Gilbert症候群は，bilirubin UDP-glucuronyl transferase（UGT1A1）活性の低下によるビリルビンのグルクロン酸抱合の障害が主たる病因と考えられている体質性黄疸である．UGT1A1は脂溶性薬物代謝の第II相に関与する酵素の遺伝子多型であり，UGT1A1活性の低下が，薬物性肝障害を発症した原因と推察された．<br>

DOI： 10.2957/kanzo.50.139

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Deficiency of forkhead box P3 and cytotoxic T-lymphocyte-associated antigen-4 gene expressions and impaired suppressor function of CD4+CD25+ T cells in patients with autoimmune hepatitis

OKUMURA Akihiko, ISHIKAWA Tetsuya, SATO Sayaka, YAMAUCHI Taeko, OSHIMA Hisae, OHASHI Tomohiko, SATO Ken, AYADA Minoru, HOTTA Naoki, KAKUMU Shinichi

Hepatology research : the official journal of the Japan Society of Hepatology 38 巻 ( 9 ) 頁： 896 - 903 2008年9月

Deficiency of forkhead box P3 and cytotoxic T-lymphocyte-associated antigen-4 gene expressions and impaired suppressor function of CD4+CD25+ T cells in patients with autoimmune hepatitis. 査読有り

Okumura A, Ishikawa T, Sato S, Yamauchi T, Oshima H, Ohashi T, Sato K, Ayada M, Hotta N, Kakumu S.

Hepatol Res 38 巻 ( 9 ) 頁： 896-903 2008年9月

Role of V alpha14+ NKT cells in the development of hepatitis B virus-specific CTL: Activation of V alpha14+ NKT cells promotes the breakage of CTL tolerance. 査読有り

Ito H, Ando K, Ishikawa T, Nakayama T, Taniguchi M, Saito K, Imawari M, Moriwaki H, Yokochi T, Kakumu S, Seishima M.

Int Immunol 20 巻 ( 7 ) 頁： 869-879 2008年7月

Use of the Model for End-Stage Liver Disease (MELD) score to predict 1-year survival of Japanese patients with cirrhosis and to determine who will benefit from living donor liver transplantation. 査読有り

Ishigami M, Honda T, Okumura A, Ishikawa T, Kobayashi M, Katano Y, Fujimoto Y, Kiuchi T, Goto H.

J Gastroenterol 43 巻 ( 5 ) 頁： 363-368 2008年5月

Upregulation of indoleamine 2,3-dioxygenase in hepatocyte during acute hepatitis caused by hepatitis B virus-specific cytotoxic T lymphocytes in vivo. 査読有り

Iwamoto N, Ito H, Ando K, Ishikawa T, Hara A, Taguchi A, Saito K, Takemura M, Imawari M, Moriwaki H, Seishima M.

Liv Int 29 巻 ( 2 ) 頁： 277-283 2008年2月

Use of hepatitis B vaccine for the treatment of chronic hepatitis B

ISHIKAWA Tetsuya, KAKUMU Shinichi

Hepatology research : the official journal of the Japan Society of Hepatology 37 巻頁： S347 - S350 2007年10月

B型肝炎の新たな治療展開 B型肝炎の治療戦略　Adefovir pivoxil

石川哲也, 各務伸一

内科 100 巻 ( 4 ) 頁： 677 - 682 2007年10月

Expression of Toll-like receptors in chronic hepatitis C virus infection. 査読有り

Sato K, Ishikawa T, Okumura A, Yamauchi T, Sato S, Ayada M, Matsumoto E, Hotta N, Ohashi T, Fukuzawa Y, Kakumu S.

J Gastroenterol Hepatol 22 巻 ( 10 ) 頁： 1627-1632 2007年10月

Use of HB vaccine for the treatment of chronic hepatitis B. 招待有り

Ishikawa T, Kakumu S.

Hepatol Res 37 巻 ( S3 ) 頁： S347-S350 2007年10月

Effect of Vitamin K2 on the recurrence in patients with hepatocellular carcinoma. 査読有り

Hotta N, Ayada M, Sato K, Ishikawa T, Okumura A, Matsumoto E, Ohashi T, Kakumu S.

Hepato-gastroenterology 54 巻 ( 79 ) 頁： 2073-2077 2007年10月

今月の主題消化器薬の使い方Update 消化器疾患の薬物治療自己免疫性肝炎(AIH)

石川哲也

medicina 44 巻 ( 9 ) 頁： 1713 - 1715 2007年9月

Double filtration plasmapheresis and interferon combination therapy for chronic hepatitis C patients with genotype 1 and high viral load

FUJIWARA Kenji, KANEKO Shuichi, KAKUMU Shinichi, SATA Michio, HIGE Shuhei, TOMITA Eiichi, MOCHIDA Satoshi, IDE T., NISHIDA H., YOKOYAMA H., YAMASHITA T., MORIWAKI H., NAGAKI M., SUGIHARA J., TAKAHASHI H., ISHIKAWA T., MIYATA M., NISHIKAWA K., NAGOSHI S., SUGAHARA S., YAMAMOTO K., MIZUTA T., ANDO T., TAKEI Y., ENOMOTO N., TSUDA H., SUMINO Y., ISHII K., SAISHO H., YOKOSUKA O., EGUCHI K., HAMASAKI K., SAWADA K., FUKUNAGA K., ARAKAWA Y., MORIYAMA M., IMAWARI M., ITO T.

Hepatology research : the official journal of the Japan Society of Hepatology 37 巻 ( 9 ) 頁： 701 - 710 2007年9月

Combination therapy with lamivudine and HB vaccine on chronic hepatitis B

ISHIKAWA Tetsuya, KAKUMU Shinichi

Hepatology research : the official journal of the Japan Society of Hepatology 37 巻頁： S62 - S66 2007年7月

Combination thearpy with lamivudine and HB vaccine on chronic heaptitis B. 招待有り

Ishikawa T, Kakumu S.

Hepatol Res 37 巻 ( S1 ) 頁： S62-S66 2007年7月

今月の主題ウイルス肝炎実地診療A to Z 扉

石川哲也

medicina 44 巻 ( 5 ) 頁： 847 - 847 2007年5月

今月の主題ウイルス肝炎実地診療A to Z 座談会外来で診るウイルス肝炎-効果的な病診連携のために

八橋弘, 伊東和樹, 柴田実, 石川哲也

medicina 44 巻 ( 5 ) 頁： 972 - 983 2007年5月

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