論文 - 早川 文彦
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The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with dasatinib. 査読有り
Morishita T, Hayakawa F, Sugimoto K, Iwase M, Yamamoto H, Hirano D, Kojima Y, Imoto N, Naoe T, Kiyoi H.
Oncotarget. 7 巻 頁： 56241 2016年7月
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Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions. 査読有り
Sugimoto K, Miyata Y, Nakayama T, Saito S, Suzuki R, Hayakawa F, Nishiwaki S, Mizuno H, Takeshita K, Kato H, Ueda R, Takami A, Naoe T.
Scientific Reports 6 巻 頁： 30779 2016年7月
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PAX5 tyrosine phosphorylation by SYK co-operatively functions with its serine phosphorylation to cancel the PAX5-dependent repression of BLIMP1: A mechanism for antigen-triggered plasma cell differentiation. 査読有り
Inagaki Y, Hayakawa F, Hirano D, Kojima Y, Morishita T, Yasuda T, Naoe T, Kiyoi H.
Biochem Biophys Res Commun. 475 巻 ( 2 ) 頁： 176 2016年5月
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SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. 査読有り
Takagi Y, Shimada K, Shimada S, Sakamoto A, Naoe T, Nakamura S, Hayakawa F, Tomita A, Kiyoi H.
Cancer Science 107 巻 ( 9 ) 頁： 1270 2016年4月
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Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults. 査読有り
Yasuda T, Tsuzuki S, Kawazu M, Hayakawa F, Kojima S, Ueno T, Imoto N, Kohsaka S, Kunita A, Doi K, Sakura T, Yujiri T, Kondo E, Fujimaki K, Ueda Y, Aoyama Y, Ohtake S, Takita J, Sai E, Taniwaki M, Kurokawa M, Morishita S, Fukayama M, Kiyoi H, Miyazaki Y, Naoe T, Mano H.
Nature Genetics 48 巻 ( 5 ) 頁： 569 2016年3月
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Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma. 査読有り
Shimada K, Shimada S, Sugimoto K, Nakatochi M, Suguro M, Hirakawa A, Hocking TD, Takeuchi I, Tokunaga T, Takagi Y, Sakamoto A, Aoki T, Naoe T, Nakamura S, Hayakawa F, Seto M, Tomita A, Kiyoi H.
Leukemia 30 巻 ( 7 ) 頁： 1568 2016年2月
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Wnt signaling is associated with cell survival in the interaction between acute myeloid leukemia cells and stromal cells. 査読有り
Niwa Y, Minami Y, Abe A, Hayakawa F, Yamada K, Naoe T.
Leukemia & Lymphoma 57 巻 ( 9 ) 頁： 2192 2016年1月
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B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia. 査読有り
Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, Sugimoto K, Tsuzuki S, Naoe T, Kiyoi H.
Journal of Biological Chemistry 291 巻 ( 9 ) 頁： 4723 2016年1月
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Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells. 査読有り 国際共著
Fukushima N, Minami Y, Kakiuchi S, et al.
Cancer Science 107 巻 頁： 1422 2016年
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【臨床血液学-最新情報と今後の展望2016(リンパ系疾患)-】 成人急性リンパ性白血病 招待有り 査読有り
早川文彦
臨床血液 57 巻 頁： 230 2016年
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Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions. 査読有り
Sugimoto K, Miyata Y, Nakayama T, et al.
Scientific reports 6 巻 頁： 30799 2016年
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Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells 査読有り
Keiki Sugimoto, Fumihiko Hayakawa, Satoko Shimada, Takanobu Morishita, Kazuyuki Shimada, Tomoya Katakai, Akihiro Tomita, Hitoshi Kiyoi, Tomoki Naoe
Scientific reports 5 巻 頁： 13054 2015年8月
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Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies. 査読有り
Ogura M, Uchida T, Terui Y, Hayakawa F, Kobayashi Y, Taniwaki M, Takamatsu Y, Naoe T, Tobinai K, Munakata W, Yamauchi T, Kageyama A, Yuasa M, Motoyama M, Tsunoda T, Hatake K.
Cancer Science 106 巻 ( 7 ) 頁： 896-901 2015年5月
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Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoform expression profile mediated by bcr-abl in chronic myeloid leukemia. 査読有り
Shinohara H, Taniguchi K, Kumazaki M, Yamada N, Ito Y, Otsuki Y, Uno B, Hayakawa F, Minami Y, Naoe T, Akao Y.
Cancer Letter 360 巻 ( 1 ) 頁： 28-38 2015年1月
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Adolescent and young adult世代の急性リンパ性白血病 招待有り 査読有り
早川文彦
臨床血液 56 巻 頁： 2032 2015年
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Development of acute pure red cell aplasia after deferasirox administration in two cases of myelodysplastic syndrome. 査読有り
Hayakawa F, Tomita A, Naoe T.
Rinsho Ketsueki 55 巻 ( 4 ) 頁： 445-9 2014年
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Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group. 査読有り
Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T
Blood Cancer Journal 4 巻 ( e ) 頁： 252 2014年
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GATA2 zinc finger 2 mutation found in acute myeloid leukemia impairs myeloid differentiation. 査読有り
Niimi K, Kiyoi H, Ishikawa Y, Hayakawa F, Kurahashi S, Kihara R, Tomita A, Naoe T.
Leuk Res Rep 2 巻 ( 1 ) 頁： 21-5 2013年
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A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases. 査読有り
Hayakawa F, Sugimoto K, Harada Y, Hashimoto N, Ohi N, Kurahashi S, Naoe T.
Blood Cancer Journal 3 巻 ( e ) 頁： 166 2013年
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B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation. 査読有り
Yasuda T,Hayakawa F,Kurahashi S, Sugimoto K, Miyami Y, Tomita A, Naoe
Journal of Immunology 188 巻 ( 12 ) 頁： 6127-34 2012年