Papers - HAYAKAWA, Fumihiko
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The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with dasatinib. Reviewed
Morishita T, Hayakawa F, Sugimoto K, Iwase M, Yamamoto H, Hirano D, Kojima Y, Imoto N, Naoe T, Kiyoi H.
Oncotarget. Vol. 7 page： 56241 2016.7
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Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions. Reviewed
Sugimoto K, Miyata Y, Nakayama T, Saito S, Suzuki R, Hayakawa F, Nishiwaki S, Mizuno H, Takeshita K, Kato H, Ueda R, Takami A, Naoe T.
Scientific Reports Vol. 6 page： 30779 2016.7
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PAX5 tyrosine phosphorylation by SYK co-operatively functions with its serine phosphorylation to cancel the PAX5-dependent repression of BLIMP1: A mechanism for antigen-triggered plasma cell differentiation. Reviewed
Inagaki Y, Hayakawa F, Hirano D, Kojima Y, Morishita T, Yasuda T, Naoe T, Kiyoi H.
Biochem Biophys Res Commun. Vol. 475 ( 2 ) page： 176 2016.5
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SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. Reviewed
Takagi Y, Shimada K, Shimada S, Sakamoto A, Naoe T, Nakamura S, Hayakawa F, Tomita A, Kiyoi H.
Cancer Science Vol. 107 ( 9 ) page： 1270 2016.4
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Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults. Reviewed
Yasuda T, Tsuzuki S, Kawazu M, Hayakawa F, Kojima S, Ueno T, Imoto N, Kohsaka S, Kunita A, Doi K, Sakura T, Yujiri T, Kondo E, Fujimaki K, Ueda Y, Aoyama Y, Ohtake S, Takita J, Sai E, Taniwaki M, Kurokawa M, Morishita S, Fukayama M, Kiyoi H, Miyazaki Y, Naoe T, Mano H.
Nature Genetics Vol. 48 ( 5 ) page： 569 2016.3
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Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma. Reviewed
Shimada K, Shimada S, Sugimoto K, Nakatochi M, Suguro M, Hirakawa A, Hocking TD, Takeuchi I, Tokunaga T, Takagi Y, Sakamoto A, Aoki T, Naoe T, Nakamura S, Hayakawa F, Seto M, Tomita A, Kiyoi H.
Leukemia Vol. 30 ( 7 ) page： 1568 2016.2
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Wnt signaling is associated with cell survival in the interaction between acute myeloid leukemia cells and stromal cells. Reviewed
Niwa Y, Minami Y, Abe A, Hayakawa F, Yamada K, Naoe T.
Leukemia & Lymphoma Vol. 57 ( 9 ) page： 2192 2016.1
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B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia. Reviewed
Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, Sugimoto K, Tsuzuki S, Naoe T, Kiyoi H.
Journal of Biological Chemistry Vol. 291 ( 9 ) page： 4723 2016.1
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Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells. Reviewed International coauthorship
Fukushima N, Minami Y, Kakiuchi S, et al.
Cancer Science Vol. 107 page： 1422 2016
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Adult acute lymphoblastic leukemia: current therapies and future perspectives Invited Reviewed
Vol. 57 page： 230 2016
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Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions. Reviewed
Sugimoto K, Miyata Y, Nakayama T, et al.
Scientific reports Vol. 6 page： 30799 2016
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Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells Reviewed
Keiki Sugimoto, Fumihiko Hayakawa, Satoko Shimada, Takanobu Morishita, Kazuyuki Shimada, Tomoya Katakai, Akihiro Tomita, Hitoshi Kiyoi, Tomoki Naoe
Scientific reports Vol. 5 page： 13054 2015.8
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Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies. Reviewed
Ogura M, Uchida T, Terui Y, Hayakawa F, Kobayashi Y, Taniwaki M, Takamatsu Y, Naoe T, Tobinai K, Munakata W, Yamauchi T, Kageyama A, Yuasa M, Motoyama M, Tsunoda T, Hatake K.
Cancer Science Vol. 106 ( 7 ) page： 896-901 2015.5
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Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoform expression profile mediated by bcr-abl in chronic myeloid leukemia. Reviewed
Shinohara H, Taniguchi K, Kumazaki M, Yamada N, Ito Y, Otsuki Y, Uno B, Hayakawa F, Minami Y, Naoe T, Akao Y.
Cancer Letter Vol. 360 ( 1 ) page： 28-38 2015.1
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Adolescent and young adult世代の急性リンパ性白血病 Invited Reviewed
早川文彦
臨床血液 Vol. 56 page： 2032 2015
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Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group. Reviewed
Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T
Blood Cancer Journal Vol. 4 ( e ) page： 252 2014
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Development of acute pure red cell aplasia after deferasirox administration in two cases of myelodysplastic syndrome. Reviewed
Hayakawa F, Tomita A, Naoe T.
Rinsho Ketsueki Vol. 55 ( 4 ) page： 445-9 2014
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A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases. Reviewed
Hayakawa F, Sugimoto K, Harada Y, Hashimoto N, Ohi N, Kurahashi S, Naoe T.
Blood Cancer Journal Vol. 3 ( e ) page： 166 2013
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GATA2 zinc finger 2 mutation found in acute myeloid leukemia impairs myeloid differentiation. Reviewed
Niimi K, Kiyoi H, Ishikawa Y, Hayakawa F, Kurahashi S, Kihara R, Tomita A, Naoe T.
Leuk Res Rep Vol. 2 ( 1 ) page： 21-5 2013
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B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation. Reviewed
Yasuda T,Hayakawa F,Kurahashi S, Sugimoto K, Miyami Y, Tomita A, Naoe
Journal of Immunology Vol. 188 ( 12 ) page： 6127-34 2012