Faculty Profiles - HAYAKAWA, Fumihiko

Papers - HAYAKAWA, Fumihiko

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Nelarabine-combined chemotherapy improves outcome of T-cell acute lymphoblastic leukemia but shows more severe neurotoxicity: JALSG T-ALL213-O Reviewed International journal

Hayakawa, F; Mori, N; Imai, K; Yokoyama, Y; Katsuoka, Y; Saito, T; Murayama, T; Yamazaki, E; Sato, S; Atsuta, Y; Ishikawa, Y; Sakaida, E; Hatta, Y; Matsumura, I; Miyazaki, Y; Kiyoi, H

CANCER SCIENCE Vol. 116 ( 2 ) page： 453 - 461 2024.11

Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia Reviewed International journal

Noura, M; Matsuo, H; Yasuda, T; Tsuzuki, S; Kiyoi, H; Hayakawa, F

ONCOGENE Vol. 43 ( 6 ) page： 447 - 456 2024.2

Functional inhibition of MEF2 by C/EBP is a possible mechanism of leukemia development by CEBP-IGH fusion gene Reviewed International journal

Odaira, K; Yasuda, T; Okada, K; Shimooka, T; Kojima, Y; Noura, M; Tamura, S; Kurahashi, S; Iwamoto, E; Sanada, M; Matsumura, I; Miyazaki, Y; Kojima, T; Kiyoi, H; Tsuzuki, S; Hayakawa, F

CANCER SCIENCE Vol. 114 ( 3 ) page： 781 - 792 2023.3

Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations Reviewed International journal

Yasuda, T; Sanada, M; Kawazu, M; Kojima, S; Tsuzuki, S; Ueno, H; Iwamoto, E; Iijima-Yamashita, Y; Yamada, T; Kanamori, T; Nishimura, R; Kuwatsuka, Y; Takada, S; Tanaka, M; Ota, S; Dobashi, N; Yamazaki, E; Hirose, A; Murayama, T; Sumi, M; Sato, S; Tange, N; Nakamura, Y; Katsuoka, Y; Sakaida, E; Kawamata, T; Iida, H; Shiraishi, Y; Nannya, Y; Ogawa, S; Taniwaki, M; Asou, N; Hatta, Y; Kiyoi, H; Matsumura, I; Horibe, K; Mano, H; Naoe, T; Miyazaki, Y; Hayakawa, F

BLOOD Vol. 139 ( 12 ) page： 1850 - 1862 2022.3

Targeting MEF2D-fusion oncogenic transcriptional circuitries in B-cell precursor acute lymphoblastic leukemia Reviewed

Tsuzuki S, Yasuda T, Kojima S, Kawazu M, Akahane K, Inukai T, Imaizumi M, Morishita T, Miyamura K, Ueno T, Karnan S, Ota A, Hyodo T, Konishi H, Sanada M, Nagai H, Horibe K, Tomita A, Suzuki K, Muramatsu H, Takahashi Y, Miyazaki Y, Matsumura I, Kiyoi H, Hosokawa Y, Mano H, Hayakawa F

Blood Cancer Discovery Vol. 1 ( 1 ) page： 82 - 95 2020.7

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia Reviewed International journal

Tsuzuki, S; Yasuda, T; Kojima, S; Kawazu, M; Akahane, K; Inukai, T; Imaizumi, M; Morishita, T; Miyamura, K; Ueno, T; Karnan, S; Ota, A; Hyodo, T; Konishi, H; Sanada, M; Nagai, H; Horibe, K; Tomita, A; Suzuki, K; Muramatsu, H; Takahashi, Y; Miyazaki, Y; Matsumura, I; Kiyoi, H; Hosokawa, Y; Mano, H; Hayakawa, F

BLOOD CANCER DISCOVERY Vol. 1 ( 1 ) page： 82 - 95 2020.7

Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity Reviewed International journal

Hirano Daiki, Hayakawa Fumihiko, Yasuda Takahiko, Tange Naoyuki, Yamamoto Hideyuki, Kojima Yuki, Morishita Takanobu, Imoto Naoto, Tsuzuki Shinobu, Mano Hiroyuki, Naoe Tomoki, Kiyoi Hitoshi

ONCOGENE Vol. 38 ( 13 ) page： 2263 - 2274 2019.3

Misleading antigenic von Willebrand factor levels in acquired von Willebrand syndrome secondary to monoclonal gammopathy of undetermined significance Reviewed International journal

Okamoto, S; Suzuki, A; Tamura, S; Suzuki, N; Kanematsu, T; Suzuki, N; Kawaguchi, Y; Katsumi, A; Hayakawa, F; Kiyoi, H; Kojima, T; Matsushita, T

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 121 ( 1 ) page： 131 - 136 2025.1

JSH practical guidelines for hematological malignancies, 2023: leukemia-3. Acute lymphoblastic leukemia/lymphoblastic lymphoma: ALL/LBL Invited Reviewed International journal

Hatta, Y; Izutsu, K; Onizuka, M; Dobashi, N; Hayakawa, F; Yamazaki, E

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 120 ( 4 ) page： 394 - 413 2024.10

NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation Reviewed International journal

Noura, M; Tomita, S; Yasuda, T; Tsuzuki, S; Kiyoi, H; Hayakawa, F

CANCER MEDICINE Vol. 13 ( 13 ) page： e7445 2024.7

RGS1 and CREB5 are direct and common transcriptional targets of ZNF384-fusion proteins Reviewed International journal

Yamada, C; Okada, K; Odaira, K; Tokoro, M; Iwamoto, E; Sanada, M; Noura, M; Okamoto, S; Yasuda, T; Tsuzuki, S; Kiyoi, H; Hayakawa, F

CANCER MEDICINE Vol. 13 ( 14 ) page： e7471 2024.7

EBF1-JAK2 inhibits the PAX5 function through physical interaction with PAX5 and kinase activity Reviewed International journal

Kojima, Y; Kawashima, F; Yasuda, T; Odaira, K; Inagaki, Y; Yamada, C; Muraki, A; Noura, M; Okamoto, S; Tamura, S; Iwamoto, E; Sanada, M; Matsumura, I; Miyazaki, Y; Kojima, T; Kiyoi, H; Tsuzuki, S; Hayakawa, F

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 118 ( 1 ) page： 65 - 74 2023.7

BCL6 inhibition ameliorates resistance to ruxolitinib in CRLF2-rearranged acute lymphoblastic leukemia Reviewed International journal

Tsuzuki, S; Yasuda, T; Goto, H; Maeda, N; Akahane, K; Inukai, T; Yamamoto, H; Karnan, S; Ota, A; Hyodo, T; Konishi, H; Hosokawa, Y; Kiyoi, H; Hayakawa, F

HAEMATOLOGICA Vol. 108 ( 2 ) page： 394 - 408 2023.2

Oncogenic lesions and molecular subtypes in adults with B-cell acute lymphoblastic leukemia Invited Reviewed International journal

Yasuda, T; Sanada, M; Tsuzuki, S; Hayakawa, F

CANCER SCIENCE Vol. 114 ( 1 ) page： 8 - 15 2023.1

VWF-Gly2752Ser, a novel non-cysteine substitution variant in the CK domain, exhibits severe secretory impairment by hampering C-terminal dimer formation Reviewed International journal

Okamoto, S; Tamura, S; Sanda, N; Odaira, K; Hayakawa, Y; Mukaide, M; Suzuki, A; Kanematsu, T; Hayakawa, F; Katsumi, A; Kiyoi, H; Kojima, T; Matsushita, T; Suzuki, N

JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 20 ( 8 ) page： 1784 - 1796 2022.8

Periosteum-derived podoplanin-expressing stromal cells regulate nascent vascularization during epiphyseal marrow development Reviewed International journal

Tamura, S; Mukaide, M; Katsuragi, Y; Fujii, W; Odaira, K; Suzuki, N; Tsukiji, N; Okamoto, S; Suzuki, A; Kanematsu, T; Katsumi, A; Takagi, A; Ikeda, K; Ueyama, J; Hirayama, M; Suzuki-Inoue, K; Matsushita, T; Kojima, T; Hayakawa, F

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 298 ( 5 ) page： 101833 2022.5

F9mRNA splicing aberration due to a deep Intronic structural variation in a patient with moderate hemophilia B Reviewed International journal

Odaira, K; Kawashima, F; Tamura, S; Suzuki, N; Tokoro, M; Hayakawa, Y; Suzuki, A; Kanematsu, T; Okamoto, S; Takagi, A; Katsumi, A; Matsushita, T; Shima, M; Nogami, K; Kojima, T; Hayakawa, F

THROMBOSIS RESEARCH Vol. 213 page： 91 - 96 2022.5

Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases Reviewed International coauthorship International journal

Dai, YT; Zhang, F; Fang, H; Li, JF; Lu, G; Jiang, L; Chen, B; Mao, DD; Liu, YF; Wang, J; Peng, LJ; Feng, C; Chen, HF; Mu, JX; Zhang, QL; Wang, H; Ariffin, H; Moy, TA; Wang, JH; Lou, YJ; Chen, SN; Wang, Q; Liu, H; Shan, Z; Matsumura, I; Miyazaki, Y; Yasuda, T; Dou, LP; Yan, XJ; Yan, JS; Yeoh, AEJ; Wu, DP; Kiyoi, H; Hayakawa, F; Jin, J; Wang, SY; Sun, XJ; Mi, JQ; Chen, Z; Huang, JY; Chen, SJ

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 119 ( 15 ) page： e2120787119 2022.4

Decision Analysis for Unrelated Bone Marrow Transplantation or Immediate Cord Blood Transplantation for Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in First Remission Reviewed International journal

Kako, S; Hayakawa, F; Miyamura, K; Tanaka, J; Imai, K; Kanda, J; Morishima, S; Uchida, N; Doki, N; Ikegame, K; Ozawa, Y; Takada, S; Usui, N; Ohtake, S; Kiyoi, H; Matsumura, I; Miyazaki, Y; Ichinohe, T; Fukuda, T; Atsuta, Y; Kanda, Y

TRANSPLANTATION AND CELLULAR THERAPY Vol. 28 ( 3 ) page： 161.e1 - 161.e10 2022.3

Protein S-Leu17Pro disrupts the hydrophobicity of its signal peptide causing a proteasome-dependent degradation Reviewed International journal

Okada, K; Tamura, S; Suzuki, N; Odaira, K; Mukaide, M; Fujii, W; Katsuragi, Y; Suzuki, A; Kanematsu, T; Okamoto, S; Suzuki, N; Katsumi, A; Matsushita, T; Kojima, T; Hayakawa, F

THROMBOSIS RESEARCH Vol. 210 page： 26 - 32 2022.2

Dasatinib-based 2-step induction for adults with Philadelphia chromosome-positive acute lymphoblastic leukemia Reviewed International journal

Sugiura, I; Doki, N; Hata, T; Cho, R; Ito, T; Suehiro, Y; Tanaka, M; Kako, S; Matsuda, M; Yokoyama, H; Ishikawa, Y; Taniguchi, Y; Hagihara, M; Ozawa, Y; Ueda, Y; Hirano, D; Sakura, T; Tsuji, M; Kamae, T; Fujita, H; Hiramoto, N; Onoda, M; Fujisawa, S; Hatta, Y; Dobashi, N; Nishiwaki, S; Atsuta, Y; Kobayashi, Y; Hayakawa, F; Ohtake, S; Naoe, T; Miyazaki, Y

BLOOD ADVANCES Vol. 6 ( 2 ) page： 624 - 636 2022.1

Optimal treatment for Philadelphia-negative acute lymphoblastic leukemia in first remission in the era of high-intensity chemotherapy Reviewed International journal

Kako, S; Hayakawa, F; Imai, K; Tanaka, J; Mizuta, S; Nishiwaki, S; Kanamori, H; Mukae, J; Ozawa, Y; Kondo, T; Fukuda, T; Ichinohe, T; Ota, S; Tanaka, Y; Murayama, T; Kurahashi, S; Sakura, T; Usui, N; Ohtake, S; Kiyoi, H; Matsumura, I; Miyazaki, Y; Atsuta, Y

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 114 ( 5 ) page： 608 - 619 2021.11

Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma Reviewed International journal

Kunou, S; Shimada, K; Takai, M; Sakamoto, A; Aoki, T; Hikita, T; Kagaya, Y; Iwamoto, E; Sanada, M; Shimada, S; Hayakawa, F; Oneyama, C; Kiyoi, H

ONCOGENE Vol. 40 ( 23 ) page： 3989 - 4003 2021.6

Essential role of a carboxyl-terminal α-helix motif in the secretion of coagulation factor XI Reviewed International journal

Hayakawa, Y; Tamura, S; Suzuki, N; Odaira, K; Tokoro, M; Kawashima, F; Hayakawa, F; Takagi, A; Katsumi, A; Suzuki, A; Okamoto, S; Kanematsu, T; Matsushita, T; Kojima, T

JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 19 ( 4 ) page： 920 - 930 2021.4

Combination of clofarabine, etoposide, and cyclophosphamide in adult relapsed/refractory acute lymphoblastic leukemia: a phase 1/2 dose-escalation study by the Japan Adult Leukemia Study Group Reviewed International journal

Saito, T; Hatta, Y; Hayakawa, F; Takahashi, T; Hagihara, M; Iida, H; Minauchi, K; Yamazaki, E; Sugiura, I; Murayama, T; Sakura, T; Mori, N; Imai, K; Yahagi, Y; Atsuta, Y; Saito, AM; Hirakawa, A; Kiyoi, H; Matsumura, I; Miyazaki, Y

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 113 ( 3 ) page： 395 - 403 2021.3

Exosomes derived from cancer associated fibroblasts induce a resistance to histone deacetylase inhibitors in lymphoma Reviewed International journal

Kagaya, Y; Shimada, K; Kunou, S; Hikita, T; Sakamoto, A; Hayakawa, F; Oneyama, C; Kiyoi, H

CANCER SCIENCE Vol. 112 page： 370 - 370 2021.2

[B cell acute lymphoblastic leukemia therapy: an up to date overview]. Invited Reviewed

Hayakawa F

[Rinsho ketsueki] The Japanese journal of clinical hematology Vol. 62 ( 8 ) page： 1094 - 1101 2021

Functional analysis of a novel fusion protein PAX5-KIDINS220 identified in a pediatric Ph-like ALL patient Reviewed International journal

Kanayama Takuyo, Imamura Toshihiko, Mayumi Azusa, Soma Emi, Sakamoto Kenichi, Hayakawa Fumihiko, Tanizawa Akihiko, Kiyokawa Nobutaka, Hosoi Hajime

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 112 ( 5 ) page： 714 - 719 2020.11

JSH practical guidelines for hematological malignancies, 2018: I. leukemia-3. acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL) Invited Reviewed International journal

Hatta, Y; Hayakawa, F; Yamazaki, E

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 112 ( 4 ) page： 439 - 458 2020.10

Aberrant X chromosomal rearrangement through multi-step template switching during sister chromatid formation in a patient with severe hemophilia A Reviewed International journal

Tokoro Mahiru, Tamura Shogo, Suzuki Nobuaki, Kakihara Misaki, Hattori Yuna, Odaira Koya, Suzuki Sachiko, Takagi Akira, Katsumi Akira, Hayakawa Fumihiko, Okamoto Shuichi, Suzuki Atsuo, Kanematsu Takeshi, Matsushita Tadashi, Kojima Tetsuhito

MOLECULAR GENETICS & GENOMIC MEDICINE Vol. 8 ( 9 ) page： e1390 2020.9

Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells. Reviewed International journal

Tange N, Hayakawa F, Yasuda T, Odaira K, Yamamoto H, Hirano D, Sakai T, Terakura S, Tsuzuki S, Kiyoi H

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Vol. 128 page： 110330 2020.8

A case of pemphigus with anti-desmoglein 3 and anti-desmocollin 2 and 3 autoantibodies, associated with follicular lymphoma and bronchiolitis obliterans. Reviewed International journal

Yoshikawa M, Takeichi T, Taki T, Hayakawa F, Ishii N, Hashimoto T, Muro Y, Akiyama M

European journal of dermatology : EJD Vol. 30 ( 4 ) page： 424 - 425 2020.7

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia.

Blood cancer discovery Vol. 1 ( 1 ) page： 82 - 95 2020.7

High prevalence of MEF2D fusion in human B-cell precursor acute lymphoblastic leukemia cell lines. Reviewed

Akahane K, Yasuda T, Tsuzuki S, Hayakawa F, Kiyokawa N, Somazu S, Watanabe A, Kagami K, Abe M, Harama D, Goi K, Kawazu M, Kojima S, Imamura T, Goto H, Iwamoto S, Minegishi M, Abe M, Hojo H, Inaba T, Mano H, Sugita K, Inukai T

Hematological oncology 2020.6

Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells Reviewed International journal

Inoue Chisato, Sobue Sayaka, Kawamoto Yoshiyuki, Nishizawa Yuji, Ichihara Masatoshi, Abe Akihiro, Hayakawa Fumihiko, Suzuki Motoshi, Nozawa Yoshinori, Murate Takahsi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 525 ( 4 ) page： 1074 - 1080 2020.5

Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes Reviewed

Inoue Chisato, Sobue Sayaka, Mizutani Naoki, Kawamoto Yoshiyuki, Nishizawa Yuji, Ichihara Masatoshi, Takeuchi Toshiyuki, Hayakawa Fumihiko, Suzuki Motoshi, Ito Tetsuro, Nozawa Yoshinori, Murate Takashi

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 82 ( 2 ) page： 261-280 2020.5

Higher FVIII:C measured by chromogenic substrate assay than by one-stage assay is associated with silent hemophilic arthropathy Reviewed International journal

Ogawa Mika, Suzuki Nobuaki, Takahashi Nobunori, Tamura Shogo, Suzuki Atsuo, Suzuki Sachiko, Hattori Yuua, Kakihara Misaki, Kanematsu Takeshi, Kojima Toshihisa, Katsumi Akira, Hayakawa Fumihiko, Kojima Tetsuhito, Ishiguro Naoki, Kiyoi Hitoshi, Matsushita Tadashi

THROMBOSIS RESEARCH Vol. 188 page： 103 - 105 2020.4

Dasatinib-Based Two-Step Induction Prior to Allogeneic Hematopoietic Cell Transplantation for Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of the JALSG Ph+ALL213 Study

Sugiura Isamu, Doki Noriko, Hata Tomoko, Cho Ryuko, Ito Toshiro, Suehiro Youko, Kanamori Heiwa, Kako Shinichi, Matsuda Mitsuhiro, Yokoyama Hisayuki, Taniguchi Yasuhiro, Hagihara Maki, Ozawa Yukiyasu, Fujisawa Shin, Dobashi Nobuaki, Hatta Yoshihiro, Asada Noboru, Ohashi Kazuteru, Onishi Yasushi, Shiro Koh, Nishiwaki Satoshi, Atsuta Yoshiko, Hayakawa Fumihiko, Ohtake Shigeki, Miyazaki Yasushi

BLOOD Vol. 134 2019.11

ZNF384-fusion proteins have high affinity for the transcriptional coactivator EP300 and aberrant transcriptional activities Reviewed International journal

Yamamoto Hideyuki, Hayakawa Fumihiko, Yasuda Takahiko, Odaira Koya, Minamikawa Yuka, Tange Naoyuki, Hirano Daiki, Kojima Yuki, Morishita Takanobu, Tsuzuki Shinobu, Naoe Tomoki, Kiyoi Hitoshi

FEBS LETTERS Vol. 593 ( 16 ) page： 2151 - 2161 2019.8

Apparent synonymous mutation F9 c.87A > G causes secretion failure by in-frame mutation with aberrant splicing Reviewed International journal

Odaira Koya, Tamura Shogo, Suzuki Nobuaki, Kakihara Misaki, Hattori Yuna, Tokoro Mahiru, Suzuki Sachiko, Takagi Akira, Katsumi Akira, Hayakawa Fumihiko, Okamoto Shuichi, Suzuki Atsuo, Kanematsu Takeshi, Matsushita Tadashi, Kojima Tetsuhito

THROMBOSIS RESEARCH Vol. 179 page： 95 - 103 2019.7

Molecular basis of SERPINC1 mutations in Japanese patients with antithrombin deficiency Reviewed International journal

Tamura Shogo, Hashimoto Erika, Suzuki Nobuaki, Kakihara Misaki, Odaira Koya, Hattori Yuna, Tokoro Mahiru, Suzuki Sachiko, Takagi Akira, Katsumi Akira, Hayakawa Fumihiko, Suzuki Atsuo, Okamoto Shuichi, Kanematsu Takeshi, Matsushita Tadashi, Kojima Tetsuhito

THROMBOSIS RESEARCH Vol. 178 page： 159 - 170 2019.6

[Peri-arteriolar megakaryopoietic microenvironment via reciprocal CLEC-2/PDPN axis in bone marrow]. Invited Reviewed

Tamura S, Suzuki-Inoue K, Ozaki Y, Hayakawa F, Kojima T

[Rinsho ketsueki] The Japanese journal of clinical hematology Vol. 60 ( 7 ) page： 834-842 2019

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases Reviewed International coauthorship International journal

Li Jian-Feng, Dai Yu-Ting, Lilljebjorn Henrik, Shen Shu-Hong, Cui Bo-Wen, Bai Ling, Liu Yuan-Fang, Qian Mao-Xiang, Kubota Yasuo, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Olsson Linda, Tan Ah Moy, Ariffin Hany, Chen Jing, Takita Junko, Yasuda Takahiko, Mano Hiroyuki, Johansson Bertil, Yang Jun J., Yeoh Allen Eng-Juh, Hayakawa Fumihiko, Chen Zhu, Pui Ching-Hon, Fioretos Thoas, Chen Sai-Juan, Huang Jin-Yan

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 115 ( 50 ) page： E11711 - E11720 2018.12

A Novel PAX5-KIDINS220 Fusion Protein Activates Multiple Signals Associated with Therapeutic Resistance Reviewed International journal

Kanayama, T; Imamura, T; Sakamoto, K; Hayakawa, F; Tanizawa, A; Kiyokawa, N; Hosoi, H

BLOOD Vol. 132 2018.11

Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells.

Sakamoto A, Kunou S, Shimada K, Tsunoda M, Aoki T, Iriyama C, Tomita A, Nakamura S, Hayakawa F, Kiyoi H

Cancer science 2018.11

Biology and management of primary effusion lymphoma.

Shimada K, Hayakawa F, Kiyoi H

Blood Vol. 132 ( 18 ) page： 1879-1888 2018.11

Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia.

Tanaka Y, Kawazu M, Yasuda T, Tamura M, Hayakawa F, Kojima S, Ueno T, Kiyoi H, Naoe T, Mano H

Haematologica Vol. 103 ( 11 ) page： e522-e526 2018.11

Final analysis of the JALSG Ph+ALL202 study: tyrosine kinase inhibitor-combined chemotherapy for Ph plus ALL Reviewed International journal

Hatta Yoshihiro, Mizuta Shuichi, Matsuo Keitaro, Ohtake Shigeki, Iwanaga Masako, Sugiura Isamu, Doki Noriko, Kanamori Heiwa, Ueda Yasunori, Yoshida Chikamasa, Dobashi Nobuaki, Maeda Tomoya, Yujiri Toshiaki, Monma Fumihiko, Ito Yoshikazu, Hayakawa Fumihiko, Takeuchi Jin, Kiyoi Hitoshi, Miyazaki Yasushi, Naoe Tomoki

ANNALS OF HEMATOLOGY Vol. 97 ( 9 ) page： 1535 - 1545 2018.9

BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells. Reviewed International journal

Inoue C, Sobue S, Aoyama Y, Mizutani N, Kawamoto Y, Nishizawa Y, Ichihara M, Abe A, Hayakawa F, Suzuki M, Nozawa Y, Murate T

Biochemistry and biophysics reports Vol. 15 page： 69 - 75 2018.9

Phase I study of cord blood transplantation with intrabone marrow injection of mesenchymal stem cells: A clinical study protocol Reviewed International journal

Goto Tatsunori, Murata Makoto, Terakura Seitaro, Nishida Tetsuya, Adachi Yoshiya, Ushijima Yoko, Shimada Kazuyuki, Ishikawa Yuichi, Hayakawa Fumihiko, Nishio Nobuhiro, Nishiwaki Satoshi, Hirakawa Akihiro, Kato Katsuyoshi, Takahashi Yoshiyuki, Kiyoi Hitoshi

MEDICINE Vol. 97 ( 17 ) page： e0449 2018.4

High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG Reviewed International journal

Sakura T., Hayakawa F., Sugiura I., Murayama T., Imai K., Usui N., Fujisawa S., Yamauchi T., Yujiri T., Kakihana K., Ito Y., Kanamori H., Ueda Y., Miyata Y., Kurokawa M., Asou N., Ohnishi K., Ohtake S., Kobayashi Y., Matsuo K., Kiyoi H., Miyazaki Y., Naoe T.

LEUKEMIA Vol. 32 ( 3 ) page： 626 - 632 2018.3

High Incidence of Extensive Chronic Gvhd in Patients with the REG3A Rs7588571 Non-GG Genotype Reviewed International journal

Murata Makoto, Koyama Daisuke, Hanajiri Ryo, Okuno Shingo, Kamoshita Sonoko, Julamanee Jakrawadee, Takagi Erina, Hirano Daiki, Miyao Kotaro, Sakemura Reona, Goto Tatsunori, Hayakawa Fumihiko, Seto Aika, Ozawa Yukiyasu, Miyamura Koichi, Terakura Seitaro, Nishida Tetsuya, Kiyoi Hitoshi

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Vol. 24 ( 3 ) page： S192 - S193 2018.3

A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with FLT3 mutations Reviewed International journal

Yamaura Takeshi, Nakatani Toshiyuki, Uda Ken, Ogura Hayato, Shin Wigyon, Kurokawa Naoya, Saito Koichi, Fujikawa Norie, Date Tomomi, Takasaki Masaru, Terada Daisuke, Hirai Atsushi, Akashi Akimi, Chen Fangli, Adachi Yoshiya, Ishikawa Yuichi, Hayakawa Fumihiko, Hagiwara Shinji, Naoe Tomoki, Kiyoi Hitoshi

BLOOD Vol. 131 ( 4 ) page： 426 - 438 2018.1

The transcriptional landscape of B-cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases Reviewed

Jian-Feng Li, Yu-Ting Dai, Henrik Lilljebjörn, Shu-Hong Shen, Bo-Wen Cui, Ling Bai, Yuan-Fang Liu, Mao-Xiang Qian, Yasuo Kubota, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki, Linda Olsson, Ah Moy Tan, Hany Ariffin, Jing Chen, Junko Takita, Takahiko Yasuda, Hiroyuki Mano, Bertil Johansson, Jun J. Yang, Allen Eng-Juh Yeoh, Fumihiko Hayakawa, Zhu Chen, Ching-Hon Pui, Thoas Fioretos, Sai-Juan Chen, Jin-Yan Huang

Proceedings of the National Academy of Sciences of the United Stats of America Vol. in press ( in press ) page： in press 2018

[Adult acute lymphoblastic leukemia: update on pathophysiology and management].

Hayakawa F

[Rinsho ketsueki] The Japanese journal of clinical hematology Vol. 59 ( 5 ) page： 497 - 503 2018

High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype Reviewed International journal

Koyama Daisuke, Murata Makoto, Hanajiri Ryo, Okuno Shingo, Kamoshita Sonoko, Julamanee Jakrawadee, Takagi Erina, Hirano Daiki, Miyao Kotaro, Sakemura Reona, Goto Tatsunori, Hayakawa Fumihiko, Seto Aika, Ozawa Yukiyasu, Miyamura Koichi, Terakura Seitaro, Nishida Tetsuya, Kiyoi Hitoshi

PLOS ONE Vol. 12 ( 9 ) page： e0185213 2017.9

YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma Reviewed International journal

Kojima Yuki, Hayakawa Fumihiko, Morishita Takanobu, Sugimoto Keiki, Minamikawa Yuka, Iwase Mizuho, Yamamoto Hideyuki, Hirano Daiki, Imoto Naoto, Shimada Kazuyuki, Okada Seiji, Kiyoi Hitoshi

PHARMACOLOGICAL RESEARCH Vol. 120 page： 242 - 251 2017.6

Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism Reviewed International journal

Aoki Tomohiro, Shimada Kazuyuki, Sakamoto Akihiko, Sugimoto Keiki, Morishita Takanobu, Kojima Yuki, Shimada Satoko, Kato Seiichi, Iriyama Chisako, Kuno Shunsuke, Harada Yasuhiko, Tomita Akihiro, Hayakawa Fumihiko, Kiyoi Hitoshi

ONCOTARGET Vol. 8 ( 8 ) page： 13085 - 13098 2017.2

Acute lymphoblastic leukemia of adolescents and young adults: from the viewpoint of physicians.

Yasuda T, Hayakawa F

[Rinsho ketsueki] The Japanese journal of clinical hematology Vol. 58 ( 8 ) page： 1031 - 1037 2017

Malignant lymphoma with cardiac involvement.

Terakura S, Onji M, Iriyama C, Goto T, Ushijima Y, Shimada K, Ishikawa Y, Nishida T, Hayakawa F, Murata M, Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology Vol. 58 ( 3 ) page： 239 - 242 2017

The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with dasatinib. Reviewed

Morishita T, Hayakawa F, Sugimoto K, Iwase M, Yamamoto H, Hirano D, Kojima Y, Imoto N, Naoe T, Kiyoi H.

Oncotarget. Vol. 7 page： 56241 2016.7

Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions. Reviewed

Sugimoto K, Miyata Y, Nakayama T, Saito S, Suzuki R, Hayakawa F, Nishiwaki S, Mizuno H, Takeshita K, Kato H, Ueda R, Takami A, Naoe T.

Scientific Reports Vol. 6 page： 30779 2016.7

PAX5 tyrosine phosphorylation by SYK co-operatively functions with its serine phosphorylation to cancel the PAX5-dependent repression of BLIMP1: A mechanism for antigen-triggered plasma cell differentiation. Reviewed

Inagaki Y, Hayakawa F, Hirano D, Kojima Y, Morishita T, Yasuda T, Naoe T, Kiyoi H.

Biochem Biophys Res Commun. Vol. 475 ( 2 ) page： 176 2016.5

SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. Reviewed

Takagi Y, Shimada K, Shimada S, Sakamoto A, Naoe T, Nakamura S, Hayakawa F, Tomita A, Kiyoi H.

Cancer Science Vol. 107 ( 9 ) page： 1270 2016.4

Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults. Reviewed

Yasuda T, Tsuzuki S, Kawazu M, Hayakawa F, Kojima S, Ueno T, Imoto N, Kohsaka S, Kunita A, Doi K, Sakura T, Yujiri T, Kondo E, Fujimaki K, Ueda Y, Aoyama Y, Ohtake S, Takita J, Sai E, Taniwaki M, Kurokawa M, Morishita S, Fukayama M, Kiyoi H, Miyazaki Y, Naoe T, Mano H.

Nature Genetics Vol. 48 ( 5 ) page： 569 2016.3

Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma. Reviewed

Shimada K, Shimada S, Sugimoto K, Nakatochi M, Suguro M, Hirakawa A, Hocking TD, Takeuchi I, Tokunaga T, Takagi Y, Sakamoto A, Aoki T, Naoe T, Nakamura S, Hayakawa F, Seto M, Tomita A, Kiyoi H.

Leukemia Vol. 30 ( 7 ) page： 1568 2016.2

Wnt signaling is associated with cell survival in the interaction between acute myeloid leukemia cells and stromal cells. Reviewed

Niwa Y, Minami Y, Abe A, Hayakawa F, Yamada K, Naoe T.

Leukemia & Lymphoma Vol. 57 ( 9 ) page： 2192 2016.1

B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia. Reviewed

Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, Sugimoto K, Tsuzuki S, Naoe T, Kiyoi H.

Journal of Biological Chemistry Vol. 291 ( 9 ) page： 4723 2016.1

Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells. Reviewed International coauthorship

Fukushima N, Minami Y, Kakiuchi S, et al.

Cancer Science Vol. 107 page： 1422 2016

Adult acute lymphoblastic leukemia: current therapies and future perspectives Invited Reviewed

Vol. 57 page： 230 2016

Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions. Reviewed

Sugimoto K, Miyata Y, Nakayama T, et al.

Scientific reports Vol. 6 page： 30799 2016

Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells Reviewed

Keiki Sugimoto, Fumihiko Hayakawa, Satoko Shimada, Takanobu Morishita, Kazuyuki Shimada, Tomoya Katakai, Akihiro Tomita, Hitoshi Kiyoi, Tomoki Naoe

Scientific reports Vol. 5 page： 13054 2015.8

Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies. Reviewed

Ogura M, Uchida T, Terui Y, Hayakawa F, Kobayashi Y, Taniwaki M, Takamatsu Y, Naoe T, Tobinai K, Munakata W, Yamauchi T, Kageyama A, Yuasa M, Motoyama M, Tsunoda T, Hatake K.

Cancer Science Vol. 106 ( 7 ) page： 896-901 2015.5

Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoform expression profile mediated by bcr-abl in chronic myeloid leukemia. Reviewed

Shinohara H, Taniguchi K, Kumazaki M, Yamada N, Ito Y, Otsuki Y, Uno B, Hayakawa F, Minami Y, Naoe T, Akao Y.

Cancer Letter Vol. 360 ( 1 ) page： 28-38 2015.1

Adolescent and young adult世代の急性リンパ性白血病 Invited Reviewed

早川文彦

臨床血液 Vol. 56 page： 2032 2015

Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group. Reviewed

Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T

Blood Cancer Journal Vol. 4 ( e ) page： 252 2014

Development of acute pure red cell aplasia after deferasirox administration in two cases of myelodysplastic syndrome. Reviewed

Hayakawa F, Tomita A, Naoe T.

Rinsho Ketsueki Vol. 55 ( 4 ) page： 445-9 2014

A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases. Reviewed

Hayakawa F, Sugimoto K, Harada Y, Hashimoto N, Ohi N, Kurahashi S, Naoe T.

Blood Cancer Journal Vol. 3 ( e ) page： 166 2013

GATA2 zinc finger 2 mutation found in acute myeloid leukemia impairs myeloid differentiation. Reviewed

Niimi K, Kiyoi H, Ishikawa Y, Hayakawa F, Kurahashi S, Kihara R, Tomita A, Naoe T.

Leuk Res Rep Vol. 2 ( 1 ) page： 21-5 2013

B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation. Reviewed

Yasuda T,Hayakawa F,Kurahashi S, Sugimoto K, Miyami Y, Tomita A, Naoe

Journal of Immunology Vol. 188 ( 12 ) page： 6127-34 2012

Missense mutations in PML-RARA critical for the lack of responsiveness to arsenic trioxide treatment. Reviewed

Goto E, Tomita A, Hayakawa F, Atsumi A, Kiyoi H, Naoe T.

Blood Vol. 118 ( 6 ) page： 1600-9 2011

PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML. Reviewed

Kurahashi S, Hayakawa F, Miyata Y, Yasuda T, Minami Y, Tsuzuki S, Abe A, Naoe T.

Oncogene Vol. 30 ( 14 ) page： 1822-30 2011

The mTOR inhibitor, everolimus (RAD001), overcomes resistance to imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells. Reviewed

Kuwatsuka Y, Minami M, Minami Y, Sugimoto K, Hayakawa F, Miyata Y, Abe A, Goff DJ, Kiyoi H, Naoe T.

Blood Cancer Journal Vol. 1 ( e ) page： 17 2011

BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4. Reviewed

Suzuki M, Abe A, Imagama S, Nomura Y, Tanizaki R, Minami Y, Hayakawa F, Ito Y, Katsumi A, Yamamoto K, Emi N, Kiyoi H, Naoe T.

Eur J Haematol. Vol. 84 ( 3 ) page： 229-38 2010

Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy. Reviewed

Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CH, Wang JY, Naoe T.

Int J Hematol Vol. 88 ( 5 ) page： 471-5 2008

Acetylation of PML is involved in histone deacetylase Inhibitor-mediated apoptosis. Reviewed

Hayakawa F, Abe A, Kitabayashi I, Pandolfi PP, Naoe T.

J Biol Chem. Vol. 283 ( 36 ) page： 24420-5 2008

LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). Reviewed

Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T.

Eur J Haematol. Vol. 79 ( 1 ) page： 25-31 2007

Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing. Reviewed

Jonas BA, Varlakhanova N, Hayakawa F, Goodson M, Privalsky ML.

Mol Endocrinol Vol. 21 ( 8 ) page： 1924-39 2007

Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD. Reviewed

Okamoto M*, Hayakawa F*, Miyata Y, Watamoto K, Emi N, Abe A, Kiyoi H, Towatari M, Naoe T

Leukemia Vol. 21 ( 3 ) page： 403-10 2007

SFK-STAT pathway: an alternative and important way to malignancies. Reviewed

Hayakawa F, Naoe T

Ann N Y Acad Sci Vol. 1086 ( 1 ) page： 213-22 2006

Establishment of a stroma-dependent human acute myelomonocytic leukemia cell line, NAMO-2, with FLT3 tandem duplication. Reviewed

Abe A, Kiyoi H, Ninomiya M, Yamazaki T, Murase T, Ozeki K, Suzuki M, Hayakawa F, Katsumi A, Emi N, Naoe T

Int J Hematol Vol. 84 ( 4 ) page： 328 - 336 2006

Functional regulation of GATA-2 by acetylation. Reviewed

Hayakawa F, Towatari M, Ozawa Y, Tomita A, Privalsky ML, Saito H.

J Leukoc Biol Vol. 75 ( 3 ) page： 529-40 2004

Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis. Reviewed

Hayakawa F, Privalsky ML

Cancer Cell Vol. 5 ( 4 ) page： 389-401 2004

Life-threatening human parvovirus B19 infection transmitted by intravenous immune globulin. Reviewed

Hayakawa F, Imada K, Towatari M, Saito H.

Br J Haematol. Vol. 118 ( 4 ) page： 1187-9 2002

Histone deacetylase 3 associates with and represses the transcription factor GATA-2. Reviewed

Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, Tanimoto M, Saito H.

Blood Vol. 98 ( 7 ) page： 2116-23 2001

c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300. Reviewed

Tomita A, Towatari M, Tsuzuki S, Hayakawa F, Kosugi H, Tamai K, Miyazaki T, Kinoshita T, Saito H.

Oncogene Vol. 19 ( 3 ) page： 444-51 2000

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Reviewed

Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H, Naoe T

Oncogene Vol. 19 ( 5 ) page： 624-31 2000

Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia. Reviewed

Hayakawa F, Towatari M, Iida H, Wakao H, Kiyoi H, Naoe T, Saito H.

Brithish Journal of Haematology Vol. 101 ( 3 ) page： 521-8 1998

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