Papers - AKATSUKA, Shinya
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Ferroptosis resistance determines high susceptibility of murine A/J strain to iron-induced renal carcinogenesis. Reviewed
Cheng Z, Akatsuka S, Li GH, Mori K, Takahashi T, Toyokuni S
Cancer science Vol. 113 ( 1 ) page： 65 - 78 2022.1
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Augmented oxidative stress increases 8-oxoguanine preferentially in the transcriptionally active genomic regions.
Akatsuka S, Li GH, Kawaguchi S, Takahashi T, Yoshihara M, Suyama M, Toyokuni S
Free radical research Vol. 54 ( 11-12 ) page： 872 - 882 2020.12
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Susceptibility of Brca1<sup>(L63X/+)</sup> rat to ovarian reserve dissipation by chemotherapeutic agents to breast cancer. Reviewed
Kaseki S, Sonehara R, Motooka Y, Tanaka H, Nakamura T, Osuka S, Akatsuka S, Kajiyama H, Mashimo T, Imaoka T, Toyokuni S.
Cancer science 2025
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Elaborate cooperation of poly(rC)-binding proteins 1/2 and glutathione in ferroptosis induced by plasma-activated Ringer's lactate. Reviewed
Jiang L, Zheng H, Ishida M, Lyu Q, Akatsuka S, Motooka Y, Sato K, Sekido Y, Nakamura K, Tanaka H, Ishikawa K, Kajiyama H, Mizuno M, Hori M, Toyokuni S.
Vol. 214 page： 28 - 41 2024.3
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BRCA1 haploinsufficiency impairs iron metabolism to promote chrysotile-induced mesothelioma via ferroptosis resistance. Reviewed
Luo Y, Akatsuka S, Motooka Y, Kong Y, Zheng H, Mashimo T, Imaoka T, Toyokuni S.
Cancer science Vol. 114 ( 4 ) page： 1423 - 1436 2023.4
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Environmental impact on carcinogenesis under BRCA1 haploinsufficiency. Invited Reviewed
Toyokuni S, Kong Y, Motooka Y, Akatsuka S.
Genes Environ Vol. 45 ( 1 ) page： 2 2023.1
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Iron as spirit of life to share under monopoly. Invited Reviewed
Toyokuni S, Kong Y, Zheng H, Maeda Y, Motooka Y, Akatsuka S.
J Clin Biochem Nutr Vol. 71 ( 2 ) page： 78 - 88 2022.9
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BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance. Reviewed
Kong Y, Akatsuka S, Motooka Y, Zheng H, Cheng Z, Shiraki Y, Mashimo T, Imaoka T, Toyokuni S.
Redox biology Vol. 54 page： 102356 2022.8
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Prognostic significance of the MDM2/HMGA2 ratio and histological tumor grade in dedifferentiated liposarcoma.
Yamashita K, Kohashi K, Yamada Y, Akatsuka S, Ikuta K, Nishida Y, Toyokuni S, Oda Y
Genes, chromosomes & cancer Vol. 60 ( 1 ) page： 26 - 37 2021.1
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Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue.
Homma T, Takeda Y, Nakano T, Akatsuka S, Kinoshita D, Kurahashi T, Saitoh S, Yamada KI, Miyata S, Asao H, Goto K, Watanabe T, Watanabe M, Toyokuni S, Fujii J
Free radical biology & medicine Vol. 162 page： 255 - 265 2021.1
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Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering.
Toyokuni S, Kong Y, Cheng Z, Sato K, Hayashi S, Ito F, Jiang L, Yanatori I, Okazaki Y, Akatsuka S
Cancers Vol. 12 ( 11 ) 2020.11
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Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice.
Hayashi S, Nakamura T, Motooka Y, Ito F, Jiang L, Akatsuka S, Iwase A, Kajiyama H, Kikkawa F, Toyokuni S
Redox biology Vol. 37 page： 101726 2020.10
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Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium.
Ito F, Yanatori I, Maeda Y, Nimura K, Ito S, Hirayama T, Nagasawa H, Kohyama N, Okazaki Y, Akatsuka S, Toyokuni S
Redox biology Vol. 36 page： 101616 2020.9
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Overexpression of miR-199/214 is a distinctive feature of iron-induced and asbestos-induced sarcomatoid mesothelioma in rats.
Okazaki Y, Chew SH, Nagai H, Yamashita Y, Ohara H, Jiang L, Akatsuka S, Takahashi T, Toyokuni S
Cancer science Vol. 111 ( 6 ) page： 2016 - 2027 2020.6
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Frequent homozygous deletion of Cdkn2a/2b in tremolite-induced malignant mesothelioma in rats.
Okazaki Y, Misawa N, Akatsuka S, Kohyama N, Sekido Y, Takahashi T, Toyokuni S
Cancer science Vol. 111 ( 4 ) page： 1180 - 1192 2020.4
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<i>Mth1</i> deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice.
Funahashi S, Okazaki Y, Akatsuka S, Takahashi T, Sakumi K, Nakabeppu Y, Toyokuni S
Free radical research Vol. 54 ( 2-3 ) page： 195 - 205 2020.3
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Superiority of rat over murine model for studies on the evolution of cancer genome
Akatsuka S, Li GH, Toyokuni S.
Free Radic Res. Vol. 52 ( 11-12 ) page： 1323 - 1327 2018.12
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Expression of P-REX2a is associated with poor prognosis in endometrial malignancies. Reviewed
Takeshita S, Yamashita Y, Shiomi K, Suzuki N, Yoshida J, Naiki-Ito A, Suzuki S, Akatsuka S, Toyokuni S, Takahashi T, Mase S, Arakawa A, Sugiura-Ogasawara M, Takahashi S
Oncotarget Vol. 9 ( 37 ) page： 24778-24786 2018.5
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Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model.
Li GH, Akatsuka S, Chew SH, Jiang L, Nishiyama T, Sakamoto A, Takahashi T, Futakuchi M, Suzuki H, Sakumi K, Nakabeppu Y, Toyokuni S.
Pathol Int. Vol. 67 ( 11 ) page： 564 - 574 2017.11
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Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis.
Toyokuni S, Ito F, Yamashita K, Okazaki Y, Akatsuka S.
Free Radic Biol Med. Vol. 108 page： 610 - 626 2017.7