Papers - AKATSUKA, Shinya
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Ferroptosis resistance determines high susceptibility of murine A/J strain to iron-induced renal carcinogenesis. Reviewed
Cheng Z, Akatsuka S, Li GH, Mori K, Takahashi T, Toyokuni S
Cancer science Vol. 113 ( 1 ) page： 65 - 78 2022.1
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Augmented oxidative stress increases 8-oxoguanine preferentially in the transcriptionally active genomic regions.
Akatsuka S, Li GH, Kawaguchi S, Takahashi T, Yoshihara M, Suyama M, Toyokuni S
Free radical research Vol. 54 ( 11-12 ) page： 872 - 882 2020.12
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Susceptibility of Brca1<sup>(L63X/+)</sup> rat to ovarian reserve dissipation by chemotherapeutic agents to breast cancer. Reviewed
Kaseki S, Sonehara R, Motooka Y, Tanaka H, Nakamura T, Osuka S, Akatsuka S, Kajiyama H, Mashimo T, Imaoka T, Toyokuni S.
Cancer science 2025
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Elaborate cooperation of poly(rC)-binding proteins 1/2 and glutathione in ferroptosis induced by plasma-activated Ringer's lactate. Reviewed
Jiang L, Zheng H, Ishida M, Lyu Q, Akatsuka S, Motooka Y, Sato K, Sekido Y, Nakamura K, Tanaka H, Ishikawa K, Kajiyama H, Mizuno M, Hori M, Toyokuni S.
Vol. 214 page： 28 - 41 2024.3
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BRCA1 haploinsufficiency impairs iron metabolism to promote chrysotile-induced mesothelioma via ferroptosis resistance. Reviewed
Luo Y, Akatsuka S, Motooka Y, Kong Y, Zheng H, Mashimo T, Imaoka T, Toyokuni S.
Cancer science Vol. 114 ( 4 ) page： 1423 - 1436 2023.4
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Environmental impact on carcinogenesis under BRCA1 haploinsufficiency. Invited Reviewed
Toyokuni S, Kong Y, Motooka Y, Akatsuka S.
Genes Environ Vol. 45 ( 1 ) page： 2 2023.1
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Iron as spirit of life to share under monopoly. Invited Reviewed
Toyokuni S, Kong Y, Zheng H, Maeda Y, Motooka Y, Akatsuka S.
J Clin Biochem Nutr Vol. 71 ( 2 ) page： 78 - 88 2022.9
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BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance. Reviewed
Kong Y, Akatsuka S, Motooka Y, Zheng H, Cheng Z, Shiraki Y, Mashimo T, Imaoka T, Toyokuni S.
Redox biology Vol. 54 page： 102356 2022.8
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Prognostic significance of the MDM2/HMGA2 ratio and histological tumor grade in dedifferentiated liposarcoma.
Yamashita K, Kohashi K, Yamada Y, Akatsuka S, Ikuta K, Nishida Y, Toyokuni S, Oda Y
Genes, chromosomes & cancer Vol. 60 ( 1 ) page： 26 - 37 2021.1
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Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue.
Homma T, Takeda Y, Nakano T, Akatsuka S, Kinoshita D, Kurahashi T, Saitoh S, Yamada KI, Miyata S, Asao H, Goto K, Watanabe T, Watanabe M, Toyokuni S, Fujii J
Free radical biology & medicine Vol. 162 page： 255 - 265 2021.1
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Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering.
Toyokuni S, Kong Y, Cheng Z, Sato K, Hayashi S, Ito F, Jiang L, Yanatori I, Okazaki Y, Akatsuka S
Cancers Vol. 12 ( 11 ) 2020.11
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Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice.
Hayashi S, Nakamura T, Motooka Y, Ito F, Jiang L, Akatsuka S, Iwase A, Kajiyama H, Kikkawa F, Toyokuni S
Redox biology Vol. 37 page： 101726 2020.10
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Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium.
Ito F, Yanatori I, Maeda Y, Nimura K, Ito S, Hirayama T, Nagasawa H, Kohyama N, Okazaki Y, Akatsuka S, Toyokuni S
Redox biology Vol. 36 page： 101616 2020.9
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Overexpression of miR-199/214 is a distinctive feature of iron-induced and asbestos-induced sarcomatoid mesothelioma in rats.
Okazaki Y, Chew SH, Nagai H, Yamashita Y, Ohara H, Jiang L, Akatsuka S, Takahashi T, Toyokuni S
Cancer science Vol. 111 ( 6 ) page： 2016 - 2027 2020.6
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Frequent homozygous deletion of Cdkn2a/2b in tremolite-induced malignant mesothelioma in rats.
Okazaki Y, Misawa N, Akatsuka S, Kohyama N, Sekido Y, Takahashi T, Toyokuni S
Cancer science Vol. 111 ( 4 ) page： 1180 - 1192 2020.4
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<i>Mth1</i> deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice.
Funahashi S, Okazaki Y, Akatsuka S, Takahashi T, Sakumi K, Nakabeppu Y, Toyokuni S
Free radical research Vol. 54 ( 2-3 ) page： 195 - 205 2020.3
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Superiority of rat over murine model for studies on the evolution of cancer genome
Akatsuka S, Li GH, Toyokuni S.
Free Radic Res. Vol. 52 ( 11-12 ) page： 1323 - 1327 2018.12
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Expression of P-REX2a is associated with poor prognosis in endometrial malignancies. Reviewed
Takeshita S, Yamashita Y, Shiomi K, Suzuki N, Yoshida J, Naiki-Ito A, Suzuki S, Akatsuka S, Toyokuni S, Takahashi T, Mase S, Arakawa A, Sugiura-Ogasawara M, Takahashi S
Oncotarget Vol. 9 ( 37 ) page： 24778-24786 2018.5
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Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model.
Li GH, Akatsuka S, Chew SH, Jiang L, Nishiyama T, Sakamoto A, Takahashi T, Futakuchi M, Suzuki H, Sakumi K, Nakabeppu Y, Toyokuni S.
Pathol Int. Vol. 67 ( 11 ) page： 564 - 574 2017.11
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Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis.
Toyokuni S, Ito F, Yamashita K, Okazaki Y, Akatsuka S.
Free Radic Biol Med. Vol. 108 page： 610 - 626 2017.7
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Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma.
Chew SH, Okazaki Y, Akatsuka S, Wang S, Jiang L, Ohara Y, Ito F, Saya H, Sekido Y, Toyokuni S
Free radical biology & medicine Vol. 106 page： 91 - 99 2017.5
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Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma. Reviewed
Chew SH, Okazaki Y, Akatsuka S, Wang S, Jiang L, Ohara Y, Ito F, Saya H, Sekido Y, Toyokuni S.
Free Radic Biol Med Vol. 106 page： 91-99 2017.2
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Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma. Reviewed
Wang S, Jiang L, Han Y, Chew SH, Ohara Y, Akatsuka S, Weng L, Kawaguchi K, Fukui T, Sekido Y, Yokoi K, Toyokuni S.
Oncotarget Vol. 7 ( 43 ) page： 69565-69578 2016.10
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Dual preventive benefits of iron elimination by desferal in asbestos-induced mesothelial carcinogenesis. Reviewed
Jiang L, Chew SH, Nakamura K, Ohara Y, Akatsuka S, Toyokuni S.
Cancer Sci Vol. 107 ( 7 ) page： 908-915 2016.7
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Pain-reducing anesthesia prevents oxidative stress in human term placenta. Reviewed
Tsuzuki Y, Yamashita Y, Hattori Y, Li GH, Akatsuka S, Kotani T, Kikkawa F, Naiki-Ito A, Takahashi S, Nishiwaki K, Toyokuni S.
J Clin Biochem Nutr Vol. 58 ( 2 ) page： 156-160 2016.3
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Genome-wide Profiling of 8-Oxoguanine Reveals Its Association with Spatial Positioning in Nucleus. Reviewed
Yoshihara M, Jiang L, Akatsuka S, Suyama M, Toyokuni S.
DNA Res. Vol. 21 ( 6 ) page： 603-612 2014.12
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Connective tissue growth factor and β-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma. Reviewed
Jiang L, Yamashita Y, Chew SH, Akatsuka S, Ukai S, Wang S, Nagai H, Okazaki Y, Takahashi T, Toyokuni S.
J Pathol. Vol. 233 ( 4 ) page： 402-414 2014.8
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Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. Reviewed
Shinjo K, Yamashita Y, Yamamoto E, Akatsuka S, Uno N, Kamiya A, Niimi K, Sakaguchi Y, Nagasaka T, Takahashi T, Shibata K, Kajiyama H, Kikkawa F, Toyokuni S.
Int J Cancer. Vol. 135 ( 2 ) page： 308-218 2014.7
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Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production. Reviewed
Chew SH, Okazaki Y, Nagai H, Misawa N, Akatsuka S, Yamashita K, Jiang L, Yamashita Y, Noguchi M, Hosoda K, Sekido Y, Takahashi T, Toyokuni S.
Carcinogenesis Vol. 35 ( 1 ) page： 164-172 2014.1
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Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. Reviewed
Yamashita Y, Akatsuka S, Shinjo K, Yatabe Y, Kobayashi H, Seko H, Kajiyama H, Kikkawa F, Takahashi T, Toyokuni S.
PLoS One Vol. 8 ( 3 ) page： e57724 2013.3
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Metamorphosis of mesothelial cells with active horizontal motility in tissue culture. Reviewed
Nagai H, Chew SH, Okazaki Y, Funahashi S, Namba T, Kato T, Enomoto A, Jiang L, Akatsuka S, Toyokuni S.
Sci Rep Vol. 3 page： 1144 2013.1
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Iron overload signature in chrysotile-induced malignant mesothelioma. Reviewed
Jiang L, Akatsuka S, Nagai H, Chew SH, Ohara H, Okazaki Y, Yamashita Y, Yoshikawa Y, Yasui H, Ikuta K, Sasaki K, Kohgo Y, Hirano S, Shinohara Y, Kohyama N, Takahashi T, Toyokuni S.
J Pathol Vol. 228 ( 3 ) page： 366-377 2012.11
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Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer. Reviewed
Akatsuka S, Yamashita Y, Ohara H, Liu YT, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S.
PLoS One Vol. 7 ( 8 ) page： e43403 2012.8
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The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis. Reviewed
Kobayashi H, Yamashita Y, Iwase A, Yoshikawa Y, Yasui H, Kawai Y, Uchida K, Uno N, Akatsuka S, Takahashi T, Kikkawa F, Toyokuni S.
Fertil Steril Vol. 98 ( 2 ) page： 415-422 2012.8
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Genome-wide assessment of oxidatively generated DNA damage. Invited Reviewed
Akatsuka S, Toyokuni S.
Free Radic Res Vol. 46 ( 4 ) page： 523-530 2012.4
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Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Reviewed
Nagai H, Okazaki Y, Chew SH, Misawa N, Yamashita Y, Akatsuka S, Ishihara T, Yamashita K, Yoshikawa Y, Yasui H, Jiang L, Ohara H, Takahashi T, Ichihara G, Kostarelos K, Miyata Y, Shinohara H, Toyokuni S.
Proc Natl Acad Sci U S A. Vol. 108 ( 49 ) page： E1330-E1338 2011.12
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Free calvarial periosteum graft vascularized by an omental flap in a rat model. Reviewed
Nakazato K, Toriyama K, Hishida M, Takanari K, Yagi S, Yamashita Y, Akatsuka S, Hayakawa A, Kamei Y.
Ann Plast Surg Vol. 67 ( 6 ) page： 649-654 2011.12
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Age- and sun exposure-dependent differences in 8-hydroxy-2'-deoxyguanosine and N-(carboxymethyl)lysine in human epidermis. Reviewed
Toyokuni S, Hirao A, Wada T, Nagai R, Date A, Yoshii T, Akatsuka S, Yamashita Y, Kawada A.
J Clin Biochem Nutr Vol. 49 ( 2 ) page： 121-124 2011.9
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XCR1 expression and biased VH gene usage are distinct features of diffuse large B-cell lymphoma initially manifesting in the bone marrow. Reviewed
Yamashita Y, Kajiura D, Tang L, Hasegawa Y, Kinoshita T, Nakamura S, Akatsuka S, Toyokuni S, Mori N.
Am J Clin Pathol Vol. 135 ( 4 ) page： 556-564 2011.4
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LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma Reviewed
Murakami H, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, Akatsuka S, Horio Y, Hida T, Kondo Y, Toyokuni S, Osada H, Sekido Y.
Cancer Res. Vol. 71 ( 3 ) page： 873-883 2011.2
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Stage-specific roles of fibulin-5 during oxidative stress-induced renal carcinogenesis in rats Reviewed
Ohara H, Akatsuka S, Nagai H, Liu YT, Jiang L, Okazaki Y, Yamashita Y, Nakamura T, Toyokuni S.
Free Radic Res Vol. 45 ( 2 ) page： 211-220 2011.2
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Genome-scale approaches to investigate oxidative DNA damage Reviewed
Akatsuka S, Toyokuni S.
J Clin Biochem Nutr Vol. 47 ( 2 ) page： 91-97 2010.9
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Suppression of SLC11A2 expression is essential to maintain duodenal integrity during dietary iron overload Reviewed
Shirase T, Mori K, Okazaki Y, Itoh K, Yamamoto M, Tabuchi M, Kishi F, Jiang L, Akatsuka S, Nakao K, Toyokuni S.
Am J Pathol Vol. 177 ( 2 ) page： 677-685 2010.8
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*A quantitative trait locus responsible for inducing B‐cell lymphoblastic lymphoma is a hotspot for microsatellite instability Reviewed
Kaszynski RH, Akatsuka S, Hiratsuka T, Jin G, Ozeki M, Okuno T, Nakamura T, Manabe T, Takakuwa T, Hiai H, Toyokuni S, Tamaki K, Tsuruyama T.
Cancer Sci Vol. 101 ( 3 ) page： 800-805 2010.3
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Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. Reviewed
Hu Q, Akatsuka S, Yamashita Y, Ohara H, Nagai H, Okazaki Y, Takahashi T, Toyokuni S.
Lab Invest Vol. 90 ( 3 ) page： 360-373 2010.3
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Genome-wide analysis identifies a tumor suppressor role for aminoacylase 1 in iron-induced rat renal cell carcinoma. Reviewed
Zhong Y, Onuki J, Yamasaki T, Ogawa O, Akatsuka S, Toyokuni S.
Carcinogenesis Vol. 30 ( 1 ) page： 158-164 2009.1
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Characteristics and modifying factors of asbestos-induced oxidative DNA damage Reviewed
Jiang L, Nagai H, Ohara H, Hara S, Tachibana M, Hirano S, Shinohara Y, Kohyama N, Akatsuka S, Toyokuni S
Cancer Sci Vol. 99 ( 11 ) page： 2142-2151 2008.11
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*Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway Reviewed
Liu YT, Shang D, Akatsuka S, Ohara H, Dutta KK, Mizushima K, Naito Y, Yoshikawa T, Izumiya M, Abe K, Nakagama H, Noguchi N, Toyokuni S
Am J Pathol Vol. 171 ( 6 ) page： 1978-1988 2007.12
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Pathological investigation of oxidative stress in the post-genomic era Reviewed
Toyokuni S, Akatsuka S.
Pathol Int Vol. 57 ( 8 ) page： 461-473 2007.12
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Association of microRNA-34a overexpression with proliferation is cell type-dependent Reviewed
Dutta KK, Zhong Y, Liu YT, Yamada T, Akatsuka S, Hu Q, Yoshihara M, Ohara H, Takehashi M, Shinohara T, Masutani H, Onuki J, Toyokuni S
Cancer Sci Vol. 98 ( 12 ) page： 1845-1852 2007.12
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Novel screening method for ultraviolet protection: combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine Reviewed
Toyokuni S, Yasui H, Date A, Hakozaki T, Akatsuka S, Kohda H, Yoshii T, Sakurai H
Pathol Int Vol. 56 ( 12 ) page： 760-762 2006.12
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Deletion and single nucleotide substitution at G:C in the kidney of gpt delta transgenic mice after ferric nitrilotriacetate treatment Reviewed
Jiang L, Zhong Y, Akatsuka S, Liu Y-T, Dutta KK, Lee W-H, Onuki J, Masymura K, Nohmi T, Toyokuni S
Cancer Sci Vol. 97 ( 11 ) page： 1159-1167 2006.11
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*Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis. Reviewed
Akatsuka S, Aung TT, Dutta KK, Jiang L, Lee W-H, Liu Y-T, Onuki J, Shirase T, Yamasaki K, Ochi H, Naito Y, Yoshikawa T, Kasai H, Tominaga Y, Sakumi K, Nakabeppu Y, Kawai Y, Uchida K, Yamasaki A, Tsuruyama T, Yamada Y, Toyokuni S
Am J Pathol Vol. 169 ( 4 ) page： 1328-1342 2006.10
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Alpha-tocopherol induces calnexin in renal tubular cells: another protective mechanism against free radical-induced cellular damage Reviewed
Lee W-H, Akatsuka S, Shirase T, Dutta KK, Jiang L, Liu Y-T, Onuki J, Yamada Y, Okawa K, Wada Y, Watanabe A, Kohro T, Noguchi N, Toyokuni S
Arch Biochem Biophys Vol. 453 ( 2 ) page： 168-178 2006.9
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What has been learned from the studies of oxidative stress-induced carcinogenesis: proposal of the concept of oxygenomics Reviewed
Toyokuni S, Akatsuka S.
J Clin Biochem Nutr Vol. 39 ( 1 ) page： 3-10 2006.7
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Susceptibility of actin to modification by 4-hydroxy-2-nonenal Reviewed
Ozeki M, Miyagawa-Hayashino A, Akatsuka S, Shirase T, Lee W-H, Uchida K, Toyokuni S
J Chromatogr B Analyt Technol Biomed Life Sci Vol. 827 ( 1 ) page： 119-126 2005.11
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Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis Reviewed
Dutta KK, Nishinaka Y, Masutani H, Akatsuka S, Aung TT, Shirase T, Lee W-H, Yamada Y, Hiai H, Yodoi J, Toyokuni S
Lab Invest Vol. 85 ( 6 ) page： 798-807 2005.6
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Redox regulation of annexin 2 and its implications for oxidative stress-induced renal carcinogenesis and metastasis Reviewed
Tanaka T, Akatsuka S, Ozeki M, Shirase T, Hiai H, Toyokuni S
Oncogene Vol. 23 ( 22 ) page： 3980-3989 2004.5
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Detection of glyceraldehyde 3-phosphate dehydrogenase messenger RNA using a peptide nucleic acid probe in paraffin-embedded archival specimens Reviewed
Hiroyasu M, Akatsuka S, Shirase T, Toda Y, Hiai H, Toyokuni S
Pathol Int Vol. 54 ( 4 ) page： 251-255 2004.4
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Effects of phenolic contents of Mauritian endemic plant extracts on promoter activities of antioxidant enzymes Reviewed
Toyokuni S, Tanaka T, Kawaguchi W, Fang NRL, Ozeki M, Akatsuka S, Hiai H, Aruoma OI, Bahorun T
Free Radic Res Vol. 37 ( 11 ) page： 1215-1224 2003.11
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Intermittent microwave irradiation facilitates antigen-antibody reaction in Western blot analysis Reviewed
Toyokuni S, Kawaguchi W, Akatsuka S, Hiroysu M, Hiai H
Pathol Int Vol. 53 ( 4 ) page： 259-261 2003.4
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Temperature dependencies of spreading coefficients of hydrocarbons on water Reviewed
Akatsuka S, Yoshigiwa H, Mori YH
J Colloid Interf Sci Vol. 172 ( 2 ) page： 335-340 1995.6