研究者詳細 - 小嶋　誠司

論文 - 小嶋　誠司

分割表示 222 件中 1 - 20 件目／全件表示 >>

Structural analysis of S-ring composed of FliFG fusion proteins in marine Vibrio polar flagellar motor. 国際誌

Takekawa N, Nishikino T, Kishikawa J-i, Hirose M, Kinoshita M, Kojima S, Minamino T, Uchihashi T, Kato T, Imada K, Homma M

mBio 15 巻 ( 10 ) 頁： e0126124 2024年9月

Regulatory Role of a Hydrophobic Core in the FliG C-Terminal Domain in the Rotary Direction of a Flagellar Motor.

Nishikino T, Hatano A, Kojima S, Homma M

Biomolecules 15 巻 ( 2 ) 2025年2月

Structural insight into sodium ion pathway in the bacterial flagellar stator from marine Vibrio.

Nishikino T, Takekawa N, Kishikawa JI, Hirose M, Kojima S, Homma M, Kato T, Imada K

Proceedings of the National Academy of Sciences of the United States of America 122 巻 ( 1 ) 頁： e2415713122 2025年1月

Structure, function, and biophysics of bacterial motility and the flagellar motor-IUPAB2024 session commentary.

Baker MAB, Kojima S

Biophysical reviews 16 巻 ( 5 ) 頁： 537 - 538 2024年10月

Deciphering the genomes of motility-deficient mutants of Vibrio alginolyticus 138-2.

Uesaka K, Inaba K, Nishioka N, Kojima S, Homma M, Ihara K

PeerJ 12 巻頁： e17126 2024年

Interaction of FlhF, SRP-like GTPase with FliF, MS ring component assembling the initial structure of flagella in marine Vibrio.

Fukushima Y, Homma M, Kojima S

Journal of biochemistry 174 巻 ( 2 ) 頁： 125 - 130 2023年7月

Purification of the Na(+)-Driven PomAB Stator Complex and Its Analysis Using ATR-FTIR Spectroscopy.

Kojima S, Homma M, Kandori H

Methods in molecular biology (Clifton, N.J.) 2646 巻頁： 95 - 107 2023年

1. Function and structure of FlaK, a master regulator of the polar flagellar genes in marine Vibrio. 査読有り

Homma M, Kobayakawa T, Hao Y, Nishikino T, Kojima S

Journal of Bacteriology 204 巻 ( 11 ) 頁： e0032022 2022年11月

Roles of the second messenger c-di-GMP in bacteria: Focusing on the topics of flagellar regulation and Vibrio spp.

Homma M, Kojima S

Genes to cells : devoted to molecular & cellular mechanisms 27 巻 ( 3 ) 頁： 157 - 172 2022年3月

The Periplasmic Domain of the Ion-Conducting Stator of Bacterial Flagella Regulates Force Generation.

Homma M, Kojima S

Frontiers in microbiology 13 巻頁： 869187 2022年

Editorial: Flagellar Motors and Force Sensing in Bacteria.

Baker MAB, Kojima S, Nord AL, Partridge JD

Frontiers in microbiology 13 巻頁： 833011 2022年

Solution structure analysis of the periplasmic region of bacterial flagellar motor stators by small angle X-ray scattering.

Liew CW, Hynson RM, Ganuelas LA, Shah-Mohammadi N, Duff AP, Kojima S, Homma M, Lee LK

Biochemical and biophysical research communications 495 巻 ( 2 ) 頁： 1614 - 1619 2018年1月

Probing the mechanism of bacterial flagella assembly by real-time fluorescent imaging

Zhuang X. -Y., Zhao Z., Homma M., Kojima S., Bai F., Lo C. -J.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 46 巻頁： S297 - S297 2017年7月

Sodium-Driven Energy Conversion for Flagellar Rotation of the Earliest Divergent Hyperthermophilic Bacterium

Takekawa Norihiko, Nishiyama Masayoshi, Kaneseki Tsuyoshi, Kanai Tamotsu, Atomi Haruyuki, Kojima Seij, Homma Michio

BIOPHYSICAL JOURNAL 110 巻 ( 3 ) 頁： 468A - 468A 2016年2月

Pressure-Speed Relationship of the Sodium-Driven Flagellar Motor of Vibrio Alginolyticus

Nishiyama Masayoshi, Shimoda Yoshiki, Kimura Yoshifumi, Terazima Masahide, Homma Michio, Kojima Seiji

BIOPHYSICAL JOURNAL 106 巻 ( 2 ) 頁： 578A - 578A 2014年1月

Structure and function of the peptidoglycan-binding (PGB) domain of bacterial flagellar motor component MotB using systematic mutagenesis and chimeric protein with Pal

Hizukuri, Y; Morton, JF; Yakushi, T; Kojima, S; Homma, M

GENES & GENETIC SYSTEMS 83 巻 ( 6 ) 頁： 488 - 488 2008年12月

The polar flagellar motor of Vibrio cholerae is driven by an Na+ motive force

Kojima S, Yamamoto K, Kawagishi I, Homma M

JOURNAL OF BACTERIOLOGY 181 巻 ( 6 ) 頁： 1927 - 1930 1999年3月

Structural insight into sodium ion pathway in the bacterial flagellar stator from marine<i>Vibrio</i>

Tatsuro Nishikino, Norihiro Takekawa, Jun-ichi Kishikawa, Mika Hirose, Seiji Kojima, Michio Homma, Takayuki Kato, Katsumi Imada

2024年7月

出版者・発行元：Cold Spring Harbor Laboratory

Abstract

Many bacteria swim in liquid or swarm on surface using the flagellum rotated by a motor driven by specific ion flow. The motor consists of the rotor and stator, and the stator converts the energy of ion flow to mechanical rotation. However, the ion pathway and the mechanism of stator rotation coupled with specific ion flow are still obscure. Here, we determined the structures of the Na<sup>+</sup>-driven stator ofVibrio, namely PomAB, in the presence and absence of sodium ions and the structure with its specific inhibitor, phenamil, by cryo-electron microscopy. The structures and following functional analysis revealed the sodium ion pathway, the mechanism of ion selectivity, and the inhibition mechanism by phenamil. We propose a model of sodium ion flow coupled with the stator rotation based on the structures. This work provides insights into the molecular mechanisms of ion specificity and conversion of the electrochemical potential into mechanical functions.

DOI： 10.1101/2024.07.15.603494

Roles of linker region flanked by transmembrane and peptidoglycan binding region of PomB in energy conversion of the Vibrio flagellar motor. 国際誌

Miyamura Y, Nishikino T, Koiwa H, Homma M, Kojima S

Genes to cells : devoted to molecular & cellular mechanisms 29 巻 ( 4 ) 頁： 282 - 289 2024年2月

Changes in the hydrophobic network of the FliG(MC) domain induce rotational switching of the flagellar motor. 国際誌

Nishikino T, Hijikata A, Kojima S, Shirai T, Kainosho M, Homma M, Miyanoiri Y

iScience 26 巻 ( 8 ) 頁： 107320 - 107320 2023年8月

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