Faculty Profiles - OHIRA, Hideki

Papers - OHIRA, Hideki

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Prospective and retrospective memory in psychopathy

OBA Takeyuki, OHIRA Hideki

The Proceedings of the Annual Convention of the Japanese Psychological Association Vol. 77 ( 0 ) page： 3EV-008 - 3EV-008 2013.9

THE WEAPON FOCUS EFFECT REVISITED: PHYSICAL SHARPNESS OR EMOTION AROUSAL

Hamamoto Yuki, Hira Shinji, Ohira Hideki

PSYCHOPHYSIOLOGY Vol. 50 page： S43 - S43 2013.9

NEURAL MECHANISMS MEDIATING ASSOCIATION OF SYMPATHETIC ACTIVITY AND EXPLORATION IN DECISION MAKING

Ohira Hideki, Matsunaga Masahiro, Murakami Hiroki, Osumi Takahiro, Fukuyama Seisuke, Shinoda Jun, Yamada Jitsuhiro

PSYCHOPHYSIOLOGY Vol. 50 page： S29 - S29 2013.9

MODULATION OF DECISION-MAKING AND ACCOMPANYING PHYSIOLOGICAL RESPONSES BY ACUTE STRESS

Yamakawa Kaori, Matsunaga Masahiro, Isowa Tokiko, Ohira Hideki

PSYCHOPHYSIOLOGY Vol. 50 page： S29 - S29 2013.9

FLEXIBLE ADJUSTMENT OF ANTICIPATORY AFFECT BY RELATIVE VALUE

Toyama, A; Ohira, H

PSYCHOPHYSIOLOGY Vol. 50 page： S29 - S29 2013.9

Neural mechanisms mediating association of sympathetic activity and exploration in decision-making.

Ohira H, Matsunaga M, Murakami H, Osumi T, Fukuyama S, Shinoda J, Yamada J

Neuroscience Vol. 246 page： 362 - 74 2013.8

NEURAL MECHANISMS MEDIATING ASSOCIATION OF SYMPATHETIC ACTIVITY AND EXPLORATION IN DECISION-MAKING

Ohira H., Matsunaga M., Murakami H., Osumi T., Fukuyama S., Shinoda J., Yamada J.

NEUROSCIENCE Vol. 246 page： 362 - 374 2013.8

Neural mechanisms mediating association of sympathetic activity and exploration in decision-making Reviewed

H. Ohira, M. Matsunaga, H. Murakami, T. Osumi, S. Fukuyama, J. Shinoda, J. Yamada

Neuroscience Vol. 246 ( 246 ) page： 362 - 374 2013.8

Language：English Publishing type：Research paper (scientific journal)

The somatic marker hypothesis asserts that decision-making can be guided by feedback of bodily states to the brain. In line with this hypothesis, the present study tested whether sympathetic activity shows an association with a tonic dimension of decision-making, exploratory tendency represented by entropy in information theory, and further examined the neural mechanisms of the association. Twenty participants performed a stochastic reversal learning task that required decision-making in an unstable and uncertain situation. Regional cerebral blood flow was evaluated using 15O-water positron emission tomography (PET), and cardiovascular indices and concentrations of catecholamine in peripheral blood were also measured, during the task. In reversal learning, increased epinephrine during the task positively correlated with larger entropy, indicating a greater tendency for exploration in decision-making. The increase of epinephrine also correlated with brain activity revealed by PET in the somatosensory cortices, anterior insula, dorsal anterior cingulate cortex, and the dorsal pons. This result is consistent with previously reported brain matrixes of representation of bodily states and interoception. In addition, activity of the anterior insula specifically correlated with entropy, suggesting possible mediation of this brain region between peripheral sympathetic arousal and exploration in decision-making. These findings shed a new light about a role of bodily states in decision-making and underlying neural mechanisms. © 2013 IBRO.

DOI： 10.1016/j.neuroscience.2013.04.050

Scopus

PubMed

Neural mechanisms mediating association of sympathetic activity and exploration in decision-making

Ohira H., Matsunaga M., Murakami H., Osumi T., Fukuyama S., Shinoda J., Yamada J.

Neuroscience Vol. 246 page： 362 - 374 2013.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Neuroscience

DOI： 10.1016/j.neuroscience.2013.04.050

Scopus

Brain-Immune Interaction Accompanying Odor-Evoked Autobiographic Memory

Matsunaga Masahiro, Bai Yu, Yamakawa Kaori, Toyama Asako, Kashiwagi Mitsuyoshi, Fukuda Kazuyuki, Oshida Akiko, Sanada Kazue, Fukuyama Seisuke, Shinoda Jun, Yamada Jitsuhiro, Sadato Norihiro, Ohira Hideki

PLOS ONE Vol. 8 ( 8 ) 2013.8

Brain-Immune Interaction Accompanying Odor-Evoked Autobiographic Memory

Matsunaga M., Bai Y., Yamakawa K., Toyama A., Kashiwagi M., Fukuda K., Oshida A., Sanada K., Fukuyama S., Shinoda J., Yamada J., Sadato N., Ohira H.

PLoS ONE Vol. 8 ( 8 ) 2013.8

Language：English Publishing type：Research paper (scientific journal) Publisher：PLoS ONE

The phenomenon in which a certain smell evokes a specific memory is known as the Proust phenomenon. Odor-evoked autobiographic memories are more emotional than those elicited by other sensory stimuli. The results of our previous study indicated that odor-evoked autobiographic memory accompanied by positive emotions has remarkable effects on various psychological and physiological activities, including the secretion of cytokines, which are immune-signaling molecules that modulate systemic inflammation. In this study, we aimed to clarify the neural substrates associated with the interaction between odor-evoked autobiographic memory and peripheral circulating cytokines. We recruited healthy male and female volunteers and investigated the association between brain responses and the concentration of several cytokines in the plasma by using positron emission tomography (PET) recordings when an autographic memory was evoked in participants by asking them to smell an odor that was nostalgic to them. Participants experienced positive emotions and autobiographic memories when nostalgic odors were presented to them. The levels of peripheral proinflammatory cytokines, such as the tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), were significantly reduced after experiencing odor-evoked autobiographic memory. Subtraction analysis of PET images indicated that the medial orbitofrontal cortex (mOFC) and precuneus/posterior cingulate cortex (PCC) were significantly activated during experiences of odor-evoked autobiographic memory. Furthermore, a correlation analysis indicated that activities of the mOFC and precuneus/PCC were negatively correlated with IFN-γ concentration. These results indicate that the neural networks including the precuneus/PCC and mOFC might regulate the secretion of peripheral proinflammatory cytokines during the experience of odor-evoked autobiographic memories accompanied with positive emotions. © 2013 Matsunaga et al.

DOI： 10.1371/journal.pone.0072523

Scopus

Neural mechanisms mediating association of sympathetic activity and exploration in decision-making. Reviewed

Neuroscience ( 246 ) page： 362-374 2013.8

Brain-Immune Interaction Accompanying Odor-Evoked Autobiographic Memory Reviewed

Masahiro Matsunaga, Yu Bai, Kaori Yamakawa, Asako Toyama, Mitsuyoshi Kashiwagi, Kazuyuki Fukuda, Akiko Oshida, Kazue Sanada, Seisuke Fukuyama, Jun Shinoda, Jitsuhiro Yamada, Norihiro Sadato, Hideki Ohira

PLOS ONE Vol. 8 ( 8 ) page： e72523 2013.8

Language：English Publishing type：Research paper (scientific journal) Publisher：PUBLIC LIBRARY SCIENCE

The phenomenon in which a certain smell evokes a specific memory is known as the Proust phenomenon. Odor-evoked autobiographic memories are more emotional than those elicited by other sensory stimuli. The results of our previous study indicated that odor-evoked autobiographic memory accompanied by positive emotions has remarkable effects on various psychological and physiological activities, including the secretion of cytokines, which are immune-signaling molecules that modulate systemic inflammation. In this study, we aimed to clarify the neural substrates associated with the interaction between odor-evoked autobiographic memory and peripheral circulating cytokines. We recruited healthy male and female volunteers and investigated the association between brain responses and the concentration of several cytokines in the plasma by using positron emission tomography (PET) recordings when an autographic memory was evoked in participants by asking them to smell an odor that was nostalgic to them. Participants experienced positive emotions and autobiographic memories when nostalgic odors were presented to them. The levels of peripheral proinflammatory cytokines, such as the tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), were significantly reduced after experiencing odor-evoked autobiographic memory. Subtraction analysis of PET images indicated that the medial orbitofrontal cortex (mOFC) and precuneus/posterior cingulate cortex (PCC) were significantly activated during experiences of odor-evoked autobiographic memory. Furthermore, a correlation analysis indicated that activities of the mOFC and precuneus/PCC were negatively correlated with IFN-gamma concentration. These results indicate that the neural networks including the precuneus/PCC and mOFC might regulate the secretion of peripheral proinflammatory cytokines during the experience of odor-evoked autobiographic memories accompanied with positive emotions.

DOI： 10.1371/journal.pone.0072523

Web of Science

Vagal nerve activity as a moderator of brain-immune relationships.

Ohira H, Matsunaga M, Osumi T, Fukuyama S, Shinoda J, Yamada J, Gidron Y

Journal of neuroimmunology Vol. 260 ( 1-2 ) page： 28 - 36 2013.7

Vagal nerve activity as a moderator of brain-immune relationships

Ohira Hideki, Matsunaga Masahiro, Osumi Takahiro, Fukuyama Seisuke, Shinoda Jun, Yamada Jitsuhiro, Gidron Yori

JOURNAL OF NEUROIMMUNOLOGY Vol. 260 ( 1-2 ) page： 28 - 36 2013.7

Vagal nerve activity as a moderator of brain-immune relationships. Reviewed

Ohira,H., Matsunaga,M., Osumi,T., Fukuyama,S., Shinoda,J., Yamada,J., &Gidron,Y.

Journal of Neuroimmunology ( 260 ) page： 28-36 2013.7

Vagal nerve activity as a moderator of brain-immune relationships Reviewed

Hideki Ohira, Masahiro Matsunaga, Takahiro Osumi, Seisuke Fukuyama, Jun Shinoda, Jitsuhiro Yamada, Yori Gidron

JOURNAL OF NEUROIMMUNOLOGY Vol. 260 ( 1-2 ) page： 28 - 36 2013.7

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

We investigated whether vagal tone, as assessed by heart rate variability (HRV), moderates the neural correlates of immune and physiological responses to acute stress. Participants with low and high baseline HRV underwent a reversal learning task as an acute stressor. Natural killer cells, norepinephrine, and adrenocorticotropic hormone in peripheral blood changed with acute stress in the high HRV group only. Activity in the prefrontal cortex and striatum correlated with the immune and physiological indices in the high HRV group. High vagal tone may reflect more flexible top-down brain regulation of immune and physiological activity. (C) 2013 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jneuroim.2013.04.011

Web of Science

Prognosis of autoimmune hepatitis showing acute presentation

Yamamoto K., Miyake Y., Ohira H., Suzuki Y., Zeniya M., Onji M., Tsubouchi H., Yoshizawa K., Morizane T., Hibi T., Aoyagi Y., Nakanuma Y., Hirohara J., Takikawa H., Ishibashi H., Shimoda S., Sakisaka S., Nakamuta M., Matsuzaki Y., Saibara T., Ueno Y., Miyakawa H., Kokudo N., Egawa H., Maehara Y., Mochida S., Sakaida I., Fujisawa T., Suzuki K., Inoue K., Ichida T., Yokosuka O., Fukui H., Moriwaki H., Mori M., Mori T., Nagino M., Sata N., Tazuma S., Yasaka T., Tsuyuguchi T., Shoda J., Honda M., Yamaue H., Unno M., Hayashi N.

Hepatology Research Vol. 43 ( 6 ) page： 630 - 638 2013.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Hepatology Research

Aim: The number of patients with autoimmune hepatitis (AIH) showing acute presentation has increased. This study aimed to assess their prognosis. Methods: A survey of AIH patients by sending questionnaires was performed, and 96 patients showing acute presentation were investigated. Results: The median age was 58 years and 78 patients (81%) were female. Eighty-four patients (88%) were positive for antinuclear antibody and/or anti-smooth muscle antibody. The median serum immunoglobulin G level was 2252mg/dL. Twenty-five patients (26%) showed histological acute hepatitis. As initial treatment, 88 patients (92%) were treated with corticosteroid, and 28 of them received pulse steroid treatment. Overall, 11 patients (11%) reached fatal outcomes (nine death and two liver transplantation). Patients with histological acute hepatitis showed higher serum bilirubin levels, lower prothrombin activities and higher prothrombin time-international normalized ratios (PT-INR) and reached fatal outcomes more frequently. With a multivariate logistic regression analysis, prothrombin activity and PT-INR at presentation was associated with fatal outcomes. Nine of 13 patients (69%) showing prothrombin activity of 40% or lower at presentation and nine of 19 patients (47%) showing PT-INR of 1.5 or higher reached fatal outcomes. Furthermore, of 13 patients showing prothrombin activity of 40% or lower and/or PT-INR of 1.5 or higher at presentation who were treated with pulse steroid treatment, four (31%) died from infectious disease. Conclusion: Prothrombin activity and PT-INR are prognostic factors for AIH showing acute presentation. Physicians should pay attention to the development of infectious disease when pulse steroid treatment is performed. © 2012 The Japan Society of Hepatology.

DOI： 10.1111/j.1872-034X.2012.01109.x

Scopus

Eye-Blink Behaviors in 71 Species of Primates

Tada Hideoki, Omori Yasuko, Hirokawa Kumi, Ohira Hideki, Tomonaga Masaki

PLOS ONE Vol. 8 ( 5 ) 2013.5

Eye-Blink Behaviors in 71 Species of Primates

Tada H., Omori Y., Hirokawa K., Ohira H., Tomonaga M.

PLoS ONE Vol. 8 ( 5 ) 2013.5

Language：English Publishing type：Research paper (scientific journal) Publisher：PLoS ONE

The present study was performed to investigate the associations between eye-blink behaviors and various other factors in primates. We video-recorded 141 individuals across 71 primate species and analyzed the blink rate, blink duration, and "isolated" blink ratio (i.e., blinks without eye or head movement) in relation to activity rhythms, habitat types, group size, and body size factors. The results showed close relationships between three types of eye-blink measures and body size factors. All of these measures increased as a function of body weight. In addition, diurnal primates showed more blinks than nocturnal species even after controlling for body size factors. The most important findings were the relationships between eye-blink behaviors and social factors, e.g., group size. Among diurnal primates, only the blink rate was significantly correlated even after controlling for body size factors. The blink rate increased as the group size increased. Enlargement of the neocortex is strongly correlated with group size in primate species and considered strong evidence for the social brain hypothesis. Our results suggest that spontaneous eye-blinks have acquired a role in social communication, similar to grooming, to adapt to complex social living during primate evolution. © 2013 Tada et al.

DOI： 10.1371/journal.pone.0066018

Scopus

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Papers - OHIRA, Hideki