研究者詳細 - 浅沼　浩之

論文 - 浅沼　浩之

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Acceleration of influenza virus clearance by Th1 cells in the nasal site of mice immunized intranasally with adjuvant-combined recombinant nucleoprotein

Tamura S.I., Miyata K., Matsuo K., Asanuma H., Takahashi H., Nakajima K., Suzuki Y., Aizawa C., Kurata T.

Journal of Immunology 156 巻 ( 10 ) 頁： 3892 - 3900 1996年5月

記述言語：日本語出版者・発行元：Journal of Immunology

The protective roles of influenza viral nucleoprotein (NP), together with the cellular mechanism of the protection in the nasal site, were examined in BALB/c mice immunized intranasally with an adjuvant (cholera toxin B subunit containing 0.2% of the whole toxin)-combined A or B virus recombinant NP. The NP-immune mice, when challenged intranasally with a sublethal dose of the virus 3 wk after immunization, had accelerated virus clearance from the nasal site in both an influenza type-specific and a nonspecific manner, as shown by the protection from high morbidity from the second day after challenge. Both type-specific and nonspecific acceleration of recovery was confirmed by the increased survival rate after challenge with a lethal dose of virus in mice immunized and boosted with adjuvant-combined NP. The acceleration of nasal virus clearance was accompanied with acceleration of type-specific systemic delayed-type hypersensitivity (DTH) and with IFN-γ production by nasal lymphocytes. The nasal lymphocytes from the immunized and challenged mice generated a significantly high level of DTH when transferred locally, but no class I MHC-restricted CTL response. Moreover, nasal CD4+ T cells, induced by NP immunization and increased in number by the subsequent challenge, were involved in the accelerated IFN-γ production. These results suggest that nasal Th1 cells, capable of producing IFN-γ and mediating DTH, are involved in the type-specific acceleration of recovery from influenza after challenge in mice immunized intranasally with adjuvant-combined NP, although the nonspecific mechanism of accelerated recovery remains to be solved.

Scopus

Reversible Optical Control of Receptor Tyrosine Kinase Activity and ERK Dynamics Using Azobenzene-Carrying DNA Aptamer Agonist 査読有り

Wakano, M.; Tsunoda, M.; Murayama, K.; Morimoto, J.; Ueki, R.; Aoyama-Ishiwatari, S.; Hirabayashi, Y.; Asanuma, H.; Sando, S.

J. Am. Chem. Soc. 147 巻 2025年3月

Protocol for controlling the strand selectivity of siRNA using acyclic artificial nucleic acids 招待有り査読有り

Current protocols 5 巻頁： e70103 2025年3月

Reaction and interaction dynamics of azobenzene-tethered DNA with T7 RNA polymerase 査読有り

Takekawa, G.; Nakasone, Y.; Kamiya, Y.; Asanuma, H.; Terazima, M.

Phys. Chem. Chem. Phys. 27 巻頁： 3302 - 3312 2025年1月

Localized Control of the Swarming of Kinesin-Driven Microtubules Using Light 査読有り国際共著

Akter, M.; Kabir, A.M.R.; Keya, J.J.; Sada, K.; Asanuma, H.; Kakugo, A.

ACS Omega 9 巻頁： 377348 - 37753 2024年8月

Photosensitization of TiO2 Electrodes Immobilized with Chiral Plasmonic Au Nanocolloids by Circularly Polarized Light Irradiation 招待有り査読有り

Kameyama, T.; Isogawa, S.; Akiyoshi, K.; Kashida, H.; Asanuma, H.; Torimoto, T.

The Journal of Chemical Physics 160 巻頁： 094709 2024年3月

DNA reaction system that acquires classical conditioning 招待有り査読有り

ACS Synthetic Biology 頁： 521 - 529 2024年1月

Highly Functional Acyclic Xeno Nucleic Acids 招待有り査読有り

Murayama, K.; Okita, H.; Asanuma, H.

Bull. Chem. Soc. Jpn. 96 巻頁： 1179 - 1187 2023年11月

Illuminating miRNA inhibition: Visualizing the interaction between anti-miRNA oligonucleotide and target miRNA using FRET 査読有り

Zhu, H.; Kamiya, Y.; Asanuma, H.

ACS Chemical Biology 18 巻頁： 2281 - 2289 2023年10月

Functionalization of Acyclic Xenonucleic Acid with Modified Nucleobases 招待有り査読有り

Murayama, K.; Yamano, Y.; Asanuma, H.

Polym. J. 55 巻頁： 743 - 752 2023年4月

Orientational control of circularly polarized luminescence from pyrene clusters using a DNA scaffold 査読有り

Chemistry - A European Journal 2023年2月

Orientational control of circularly polarized luminescence from pyrene clusters using a DNA scaffold 査読有り

Kashida, H.; Ito, Y.; Kakuta, T.; Ogoshi, T.; Asanuma, H.

Chemistry - A European Journal 2023年2月

DNA二重鎖を利用したFRET配向依存性の検討招待有り査読有り

樫田　啓, 浅沼浩之

光化学 53 巻 ( 3 ) 頁： 148 - 153 2022年12月

DNA Concentration Regulator That can be Driven for a Long Time 査読有り

Nakakuki, T.; Murayama, K.; Asanuma, H.

New Gener. Comput. 40 巻頁： 681 - 702 2022年9月

RNA以前の世界を妄想する招待有り査読有り

浅沼浩之, 村山恵司

化学と工業 75 巻 ( 8 ) 頁： 552 - 554 2022年8月

Kinesin motors driven microtubule swarming triggered by UV light 査読有り

Ishii, S.; Akter, M.; Murayama, K.; Kabir, A. M. R.; Asanuma, H.; Sada, K.; Kakugo, A.

Polym. J. 54 巻頁： 1501 - 1507 2022年7月

Methyl group configuration on acyclic threoninol nucleic acids (aTNAs) impacts supramolecular properties 査読有り

Murayama, K.; Kashida, H.; Asanuma, H.

Org. Biomol. Chem. 20 巻頁： 4115 - 4122 2022年3月

Renewable DNA proportional-integral controller with photoresponsive molecules 招待有り査読有り

Tamba, M.; Murayama, K.; Asanuma, H.; Nakakuki, T.

Micromachines 13 巻頁： 193 2022年2月

Signal Amplification Circuit Composed of Serinol Nucleic Acid for RNA Detection 査読有り

Chen, Y.; Murayama, K.; Asanuma, H.

Chemistry Letters 51 巻頁： 330 - 333 2022年2月

Unexpected Dissociation of Photoresponsive UV-ON DNA Carrying p-tert-Butyl Azobenzene under UV Light Irradiation 査読有り

Ishii, S.; Murayama, K.; Sada, K.; Asanuma, H.; Kakugo, A.

Chem. Lett. 51 巻頁： 292 - 295 2022年1月

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