研究者詳細 - 寳珠山　稔

PubMed

その他リンク： https://dblp.uni-trier.de/db/journals/neuroimage/neuroimage169.html#BagarinaoWMMHKY18

Detecting sub-second changes in brain activation patterns during interictal epileptic spike using simultaneous EEG-fMRI 国際誌 Open Access

Bagarinao, E; Maesawa, S; Ito, Y; Usui, N; Natsume, J; Watanabe, H; Hoshiyama, M; Wakabayashi, T; Sobue, G; Naganawa, S; Isoda, H

CLINICAL NEUROPHYSIOLOGY 129 巻 ( 2 ) 頁： 377 - 389 2018年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical Neurophysiology

Objective Epileptic spikes are associated with rapidly changing brain activation involving the epileptic foci and other brain regions in the “epileptic network”. We aim to resolve these activation changes using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recordings. Methods Simultaneous EEG-fMRI recordings from 9 patients with epilepsy were used in the analysis. Our method employed the whole scalp EEG data to generate regressors for the analysis of fMRI data using the general linear model. Results We were able to resolve, with milliseconds temporal resolution, changes in activation patterns involving suspected epileptic foci and other brain regions in the epileptic network during spike and slow wave. Using summary maps (called SSWAS maps) which show the activation frequency of voxels, we found that suspected epileptic foci tend to be significantly active during this interval. SSWAS maps also enabled the detection of the epileptic foci in 4 of 5 patients where the conventional event-timing-based analysis failed to identify. Conclusion These findings demonstrated the efficacy of the method and the potential application of SSWAS maps to identify epileptic foci. Significance The method could help resolve activation changes during epileptic spike and could provide insights into the underlying pathophysiology of these changes.

DOI： 10.1016/j.clinph.2017.11.018

寳珠山稔

Neurology, Psychiatry and Brain Research 27 巻頁： 21 - 26 2018年2月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Neurology Psychiatry and Brain Research

The present pilot study was aimed to clarifying neural activity related with the feed-forward function, sensory-motor integration processed before motor performance. Brain magnetic fields were recorded using a whole-head magnetoencephalography system before vocalization under various levels of surrounding noise in nine healthy volunteers. Participants were instructed to read a word presented on a monitor under auditory conditions with white noise of 60, 80, and 100-dB. The vocal strength of the participants significantly increased with an increase in the intensity of environmental noise. Neural connectivity associated with coherence was calculated among the vocalization-related brain areas selected: truncal area in the primary motor area (M1), premotor area (PM), supplementary motor area (SMA), posterior inferior frontal area (pIF), and posterior part of the superior temporal area (pST). Coherence between M1 and pIF in the frontal cortex without vocalization and auditory pST in the temporal area before vocalization was negatively correlated with the level of environmental noise and vocal strength, respectively. We considered that the findings in this pilot study are, at least partially, relevant to the feed-forward function for vocalization.

DOI： 10.1016/j.npbr.2017.12.006

Study on Estimation of MMSE Score by Using the Latency of P300 and Alpha Wave

Miwa, K; Yoshikawa, T; Furuhashi, T; Hoshiyama, M; Makino, T; Yanagawa, M; Suzuki, Y; Umegaki, H; Kuzuya, M

2018 JOINT 10TH INTERNATIONAL CONFERENCE ON SOFT COMPUTING AND INTELLIGENT SYSTEMS (SCIS) AND 19TH INTERNATIONAL SYMPOSIUM ON ADVANCED INTELLIGENT SYSTEMS (ISIS) 頁： 195 - 199 2018年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）出版者・発行元：Proceedings - 2018 Joint 10th International Conference on Soft Computing and Intelligent Systems and 19th International Symposium on Advanced Intelligent Systems, SCIS-ISIS 2018

The number of elderly people with dementia increases year by year, and about 20% of people in Japan over 65 years old are estimated to be dementia patients in 2030. Because dementia is difficult to be treated after the symptoms advance, early detection of dementia is important. The peak latency of P300 is one of the EEG (Electroencephalogram) features. It has been reported that the peak latency of P300 is dependent on MMSE (Mini-Mental State Examination) score. If MMSE score can be estimated by measuring the latency of P300, it is expected to be used for the early detection of dementia. However, no regression equation between MMSE score and the latency of P300 had been identified yet. The authors measured the peak latency of P300 of dementia patients who were attending the Geriatrics of Nagoya University hospital and identified a multiple regression equation with MMSE score as the objective variable, and the latency of P300, age, years of education, alpha wave power as the explanatory variables. The 95% confidence interval of estimated MMSE score was ±3.09.

DOI： 10.1109/SCIS-ISIS.2018.00041

その他リンク： https://dblp.uni-trier.de/db/conf/scisisis/scisisis2018.html#MiwaYFHMYSUK18

MMSEスコア推定におけるα波の偏回帰係数の同定

三輪晃暉, 吉川大弘, 古橋武, 寳珠山稔, 牧野多恵子, 柳川まどか, 鈴木祐介, 梅垣宏之, 葛谷雅文

日本知能情報ファジィ学会ファジィシステムシンポジウム講演論文集 34 巻 ( 0 ) 頁： 15 - 18 2018年

記述言語：日本語出版者・発行元：日本知能情報ファジィ学会

高齢認知症患者数は年々増加し，2030年には65歳以上の約20%が認知症患者となると推定されている．また認知症は，症状が進んでからの治療が困難であるため，早期発見が重要とされている．脳波の特徴量であるP300頂点潜時は，認知症スクリーニング検査のMMSE（Mini Mental State Examination）スコア，課題の難易度，年齢，教育歴とそれぞれ関係があることが，個々に報告されている．そのため，P300頂点潜時を計測することでMMSEスコアを推定できれば，認知症の兆候を捉えられ，認知症早期発見につながると期待される．しかしMMSEスコアとP300頂点潜時等との関係は，これまで定量的には同定されていない．そこで本研究では，名古屋大学医学部附属病院老年内科に通院している患者を対象に，オドボール課題による脳波計測実験を行い，MMSEスコアとP300頂点潜時，課題の難易度，年齢，教育歴，更に認知症と関係性があるといわれているα波の重回帰式を同定した．同定の結果，α波はMMSEスコアの推定に統計的に有意な変数であることがわかった．この重回帰式におけるMMSEスコア推定誤差の 95％信頼区間は±3.19であった．

DOI： 10.14864/fss.34.0_15

CiNii Books

Association between changes in visual evoked magnetic fields and non-motor features in Parkinson's disease

脳腫瘍により症候性West症候群を呈し、脳磁図で焦点が推定された一例

山本啓之, 寳珠山稔, 三宅未紗, 石丸聡一郎, 石原尚子, 前澤聡, 田中雅大, 岡井佑, 坂口陽子, 大野敦子, 中田智彦, 城所博之, 夏目淳

てんかん研究 35 巻 ( 2 ) 頁： 550 - 550 2017年9月

Fujisawa, Y; Minato, T; Uemura, J; Hoshiyama, M; Watanabe, H; Hirayama, M

NAGOYA JOURNAL OF MEDICAL SCIENCE 79 巻 ( 2 ) 頁： 147 - 155 2017年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

Visual dysfunction can be caused by several abnormalities, including dysfunctions in the visual cortex and retina. Our aim was to investigate changes in visual evoked brain responses in the primary visual cortex associated with Parkinson's disease (PD). Sixteen healthy control subjects and ten patients with PD participated in this study. We assessed the visual evoked magnetic field (VEF) using magnetoencephalography (MEG). Checkerboard pattern reversal (CPR) and monotonous grating pattern (MGP) stimulations were used. Magnetic resonance imaging (MRI) was performed to analyze brain volume and generate a tractogram. Cognitive and olfactory function, and Unified Parkinson's Disease Rating Scale (UPDRS) scores were evaluated in patients with PD. Four components of the VEF (1M, 2M, 3M, 4M) were observed following stimulation. For both stimuli, results from the 1M and 2M components were significantly greater and the latency of the 1M component was increased markedly in the PD group compared with the healthy control group. In the PD group, 1M latency correlated with the UPDRS score of 1 for both stimuli, and a correlation was observed between olfactory function and the UPDRS score of 3 for the CPR stimulation alone. We suggest that the conduction delay observed following visual stimulation occurs peripherally rather than in the primary visual cortex. Degeneration of selective elements of the visual system in the retina, possibly midget cells, may be involved.

DOI： 10.18999/nagjms.79.2.147

てんかん脳磁図のdipole distribution解析による焦点、伝播経路診断

PubMed

山本啓之, 寳珠山稔, 白石秀明, 岡西徹, 前澤聡, 田中雅大, 坂口陽子, 岡井祐, 伊藤祐史, 大野敦子, 中田智彦, 城所博之, 夏目淳

脳と発達 49 巻 ( Suppl. ) 頁： S433 - S433 2017年5月

Functional inter-cortical connectivity among motor-related cortices during motor imagery: A magnetoencephalographic study

Obayashi, Y; Uemura, J; Hoshiyama, M

SOMATOSENSORY AND MOTOR RESEARCH 34 巻 ( 1 ) 頁： 1 - 8 2017年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Somatosensory and Motor Research

Neural connectivity was measured during motor imagery (MI) and motor execution (ME) using magnetoencephalography in nine healthy subjects, MI, and at rest. Lower coherence values during ME and MI between sensorimotor areas than at rest, and lower values during MI between the left supplementary motor area and inferior frontal gyrus than ME suggested the sensorimotor network of MI functioned with similar connectivity to ME and that the inhibitory activity functioned continuously during MI, respectively.

DOI： 10.1080/08990220.2016.1257985

The temporal stability and variability across frequency bands in neural synchrony between primary and secondary somatosensory areas following somatosensory stimulation. Open Access

PubMed

Uemura JI, Hoshiyama M

Clinical neurophysiology practice 2 巻頁： 119 - 123 2017年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical Neurophysiology Practice

Objectives: To examine the temporal stability and variability of neuronal synchronization among the contralateral primary somatosensory cortex (cSI) and contralateral (cSII) and ipsilateral secondary somatosensory cortex (iSII) in response to median nerve stimulation. Methods: Both the spontaneous magnetoencephalography (MEG) signals as the pre-stimulus condition and somatosensory evoked magnetic-fields (SEF) were recorded in eleven healthy subjects. We calculated a phase-locking value (PLV) between two areas among cSI, cSII, and iSII in five frequency bands (theta: 5–7 Hz, alpha: 8–12 Hz, beta: 15–29 Hz, gamma-1: 30–59 Hz, and gamma-2: 60–90 Hz), and compared the PLV among in pre-stimulus and stimulus conditions. Results: The PLV between cSI and cSII for the theta band activity varied within 2 s from the stimulus onset. On the other hand, the PLV between cSI and iSII for the alpha band did not vary within 2 s. Conclusion: The fluctuation of neuronal synchrony among sensory-related cortices in response to median nerve stimulation depends on the induced frequency band and inter-region. Significance: This study is the first to report the temporal characteristic of stimulus-driven neural synchrony following somatosensory stimulation.

DOI： 10.1016/j.cnp.2017.05.002

好酸球性多発血管炎性肉芽腫症患者に生じた多発性単神経炎とステロイドミオパチーに対する理学療法

星野高志, 小口和代, 寳珠山稔

理学療法学 44 巻 ( 3 ) 頁： 226 - 231 2017年

記述言語：日本語出版者・発行元：日本理学療法士学会

【目的】多発性単神経炎とステロイドミオパチー（以下，SM）を呈した好酸球性多発血管炎性肉芽腫症（以下，EGPA）患者への理学療法（以下，PT）について報告することである。【方法】症例はEGPA を発症した40 歳代男性で多発性単神経炎により感覚障害を伴う右下垂足と左握力低下に加え，SM が疑われる近位筋力低下を呈していた。入院13 日目より開始したPT ではステロイド量および好酸球数を指標として病勢に応じて低強度の運動からはじめ，下垂足には早期から短下肢装具を使用した。SM に対する筋力強化の是非には議論があるためADL 維持程度に留めた。【結果】右下垂足と左握力低下は残存したが，近位筋力は改善し，装具装着下での歩行が可能となり，入院50 日目に退院した。【結論】EGPA に対し，1）病勢に応じた運動負荷の調節，2）多発性単神経炎による局所症状への対応，3）SM の可能性に留意すること，以上を考慮してPT を実施した。

DOI： 10.15063/rigaku.11240

Visual function assessment in stroke patients using a dynamic three-dimensional visual tasks 査読有り

Suzuki Megumi, Hoshiyama Minoru, Yamada Masayuki, Maeda Akiko, Saitoh Eiichi

Fujita Medical Journal 3 巻 ( 3 ) 頁： 67 - 71 2017年

記述言語：英語出版者・発行元：藤田学園医学会

Objectives: Patients with right-hemisphere brain lesions often show unilateral neglect, which causes various difficulties in their daily lives. Disturbances in visuospatial cognition, including unilateral neglect, can be tested quantitatively using questionnaires, yet visuospatial cognition is related not only to the visual system, but also to other cognitive and behavioral functions. Such functions should be assessed by integrative visuo-cognitive tasks. Therefore, the objective of the present study was to clarify visual disturbances in patients with brain lesions using multi-modal visual function tests including three-dimensional and dynamic visual tasks.Methods: We recruited 29 patients, 14 with right- and 15 with left-hemispheric brain lesions, and age-matched control subjects. We conducted depth perception tests and static and active motion detection tests to clarify subjects' three-dimensional visual recognition performance.Results: There were no significant differences between the patients and controls on any of the visual function tests, except for the static detection test with a mosaic background. However, patients' total scores on the visual function tests were lower than those of the controls.Discussion: The observed decline in total visual function scores suggests that visual dysfunction caused by stroke should be evaluated not by a single visual function test, but by a series of such tests. We propose that visual functioning in daily life should be evaluated using multi-modal visual function tests.

DOI： 10.20407/fmj.3.3_67

Neuroscientific evidence for multisensory convergence and interaction 招待有り

Tanaka E, Kida T, Kakigi R, Hoshiyama M

The Journal of Physical Fitness and Sports Medicine 6 巻 ( 5 ) 頁： 301 - 310 2017年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本体力医学会

Effective behaviors optimized for various situations are enabled by various sensory information. How does the brain deal simultaneously with information from different sensory systems? Investigation of multisensory processing began from neuroanatomical and neurophysiological studies at the level of single neurons. Accumulation of knowledge concerning neurons and progress in recording techniques of human brain activity have led to a massive expansion in recent neuroscientific studies using various combinations of brain activity recording and cognitive tasks. In this paper, we briefly review recent neuroscientific studies related to multisensory convergence and interaction, focusing on electrophysiological and imaging studies in humans.

DOI： 10.7600/jpfsm.6.301

CiNii Books

急性期脳卒中者の自律神経機能の回復過程

星野高志, 小口和代, 寳珠山稔

理学療法学Supplement 2016 巻 ( 0 ) 頁： 1023 2017年

記述言語：日本語出版者・発行元：公益社団法人日本理学療法士協会

【はじめに】急性期脳卒中では自律神経機能（autonomic nervous function，ANF）の低下が報告されているが詳細は明らかではない（Orlandi, 2000）。脳卒中早期のリハビリテーション（リハ）において，姿勢変化による血圧変動は脳血流に直接影響するため十分考慮すべき点であり，ANFの測定には非侵襲性，簡便性から心拍変動（heart rate variability，HRV）がよく用いられる（Raedt, 2015）。また，脳卒中の主な併存症である糖尿病（DM）患者においてもANFは低下する（Stuckey, 2013）。本研究ではHRVを用いて急性期脳卒中におけるANFの回復過程をDMの併存に着目して検討した。【方法】対象は急性期初発脳卒中者のうち，自律神経作動薬の使用者や，著明な不整脈，DM性末梢神経障害を有するものを除外した30名とし，DMのないS群DMを有するDM群に分けた。第7病日までを評価期間とし，各回背臥位（pre），端座位（sit），背臥位（post）の順に姿勢変換した。HRVは各姿勢5分間の心拍データを周波数解析し，高周波成分（HF：0.15～0.4Hz）のnormalized unit（HFnu）を副交感神経，低周波成分（LF：0.04～0.15Hz）とHFの比（LF/HF比）を交感神経の指標とした。心拍数（HR），血圧（SBP，DBP）は3回の平均を用いた。各指標の姿勢変換による影響と経時的変化を検討した。統計処理はTukey-Kramer法，Spearmanの順位相関係数を用い，有意水準は5%未満とした。【結果】S群は23名（平均60±11歳，NIHSS 8点（中央値）），DM群は7名（59±13歳，NIHSS 5点，HbA1c 6.7%（中央値））であった。S群では第3病日以降，HFnuはsitで低下しpostで上昇，LF/HF比，DBP，HRはsitで上昇しpostで低下する一定の変化を示した。経時的にはLF/HF比，HFnu，SBPおよびHRで第2，第3病日に比べ第7病日で有意差が見られ，HFnuは経過日数と正の相関，LF/HF比，SBP，HRは負の相関を示した。一方，DM群では姿勢変換に対し，第4病日以降，HRのみsitで上昇を示したが，他の指標は第7病日においても一定しなかった。SBPのみ経過日数と負の相関を示した。【結論】DMのない急性期脳卒中者のANFは，第3病日には交感神経，副交感神経とも姿勢変換に適応して変化し，経時的に副交感神経は第7病日まで日ごとに上昇，交感神経は低下していた。これは，発症直後は交感神経活動が亢進しておりSBP，HRが高値となるが，1週までに副交感神経活動が徐々に上昇することを示唆していた。またDM併存症例では一定の傾向を示さず，1週後でもANFは安定していないと考えられた。これらは脳卒中早期リハ実施におけるリスク管理上，考慮すべき点と考えられた。

DOI： 10.14900/cjpt.2016.1023