研究者詳細 - 寳珠山　稔

Connectivity of neural signals to the primary motor area during preparatory periods for movement following external and internal cues 国際誌

脳磁図による疼痛病態特異的な機能異常の検出と解析．

岩月克之, 寳珠山稔

ペインクリニック 40 巻頁： 1179 - 1185 2019年

Feed-forward-related neural activity for vocalization: A pilot study using magnetoencephalography 査読有り

寳珠山稔

Neurology, Psychiatry and Brain Research 27 巻頁： 21 - 26 2018年

Kudo, J; Hoshiyama, M

SOMATOSENSORY AND MOTOR RESEARCH 42 巻 ( 1 ) 頁： 28 - 37 2025年1月

Imbalance in positive and negative acceleration ratio of alpha oscillation in patients with complex regional pain syndrome 国際誌 Open Access

Sano, M; Iwatsuki, K; Hirata, H; Hoshiyama, M

HELIYON 10 巻 ( 17 ) 頁： e36463 2024年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Heliyon

Objectives: To elucidate the functional characteristics of the brain in the presence of chronic pain using electroencephalography (EEG), with a focus on the dynamics of neural excitation and inhibition. Methods: Resting-state EEG was performed in: 17 patients with complex regional pain syndrome (CRPS) who exhibited chronic pain higher than 20 on the visual analogue scale (VAS), 6 patients with reduced CRPS symptoms and chronic pain less than 20 on VAS, and healthy age-matched controls. For the analysis, 50 s of electroencephalogram (EEG) signals were extracted from EEG recordings during wakefulness and rest with eyes closed. The envelope of the alpha frequency band was calculated by examining the positive and negative accelerations of the envelope oscillation, ratio of positive (Ap) to negative (An) accelerations (Ap-An ratio), and mean amplitude of the envelope. Comparisons were made between patients and controls, and correlations between these EEG measures and the subjective pain VAS were evaluated. Significant differences in the value of Ap, An and Ap-An ratio were observed at temporal and central electrodes between patients with pain symptoms and controls. Those with reduced CRPS symptoms exhibited a distinct Ap-An ratio at the majority of electrodes when compared with those exhibiting chronic pain. Conclusions: Distinct patterns in alpha wave envelope dynamics, reflecting excitatory and inhibitory activities, were associated with chronic pain in patients with CRPS. The pain-relieved state of CRPS suggested that a new balance of activities was established. This relationship indicated a potential association between altered alpha oscillation characteristics and the subjective experience of pain. Significance: This study introduces a novel method for analyzing alpha oscillation envelopes, providing new insights into the neural pathophysiology of chronic pain in CRPS patients. This approach has the potential to enhance our understanding of the alterations in brain function that occur under chronic pain conditions.

DOI： 10.1016/j.heliyon.2024.e36463

Analysis of the alpha activity envelope in electroencephalography in relation to the ratio of excitatory to inhibitory neural activity 国際誌 Open Access

Sano, M; Nishiura, Y; Morikawa, I; Hoshino, A; Uemura, JI; Iwatsuki, K; Hirata, H; Hoshiyama, M

PLOS ONE 19 巻 ( 6 ) 頁： e0305082 2024年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PLoS ONE

Alpha waves, one of the major components of resting and awake cortical activity in human electroencephalography (EEG), are known to show waxing and waning, but this phenomenon has rarely been analyzed. In the present study, we analyzed this phenomenon from the viewpoint of excitation and inhibition. The alpha wave envelope was subjected to secondary differentiation. This gave the positive (acceleration positive, Ap) and negative (acceleration negative, An) values of acceleration and their ratio (Ap-An ratio) at each sampling point of the envelope signals for 60 seconds. This analysis was performed on 36 participants with Alzheimer's disease (AD), 23 with frontotemporal dementia (FTD) and 29 age-matched healthy participants (NC) whose data were provided as open datasets. The mean values of the Ap-An ratio for 60 seconds at each EEG electrode were compared between the NC and AD/FTD groups. The AD (1.41 ±0.01 (SD)) and FTD (1.40 ±0.02) groups showed a larger Ap-An ratio than the NC group (1.38 ±0.02, p<0.05). A significant correlation between the envelope amplitude of alpha activity and the Ap-An ratio was observed at most electrodes in the NC group (Pearson's correlation coefficient, r = -0.92 ±0.15, mean for all electrodes), whereas the correlation was disrupted in AD (-0.09 ±0.21, p<0.05) and disrupted in the frontal region in the FTD group. The present method analyzed the envelope of alpha waves from a new perspective, that of excitation and inhibition, and it could detect properties of the EEG, Ap-An ratio, that have not been revealed by existing methods. The present study proposed a new method to analyze the alpha activity envelope in electroencephalography, which could be related to excitatory and inhibitory neural activity.

DOI： 10.1371/journal.pone.0305082

Cerebellar and thalamic connector hubs facilitate the involvement of visual and cognitive networks in essential tremor 国際誌

Bagarinao, E; Maesawa, S; Kato, S; Mutoh, M; Ito, Y; Ishizaki, T; Tanei, T; Tsuboi, T; Suzuki, M; Watanabe, H; Hoshiyama, M; Isoda, H; Katsuno, M; Sobue, G; Saito, R

PARKINSONISM & RELATED DISORDERS 121 巻頁： 106034 - 106034 2024年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Parkinsonism and Related Disorders

Introduction: Connector hubs are specialized brain regions that connect multiple brain networks and therefore have the potential to affect the functions of multiple systems. This study aims to examine the involvement of connector hub regions in essential tremor. Methods: We examined whole-brain functional connectivity alterations across multiple brain networks in 27 patients with essential tremor and 27 age- and sex-matched healthy controls to identify affected hub regions using a network metric called functional connectivity overlap ratio estimated from resting-state functional MRI. We also evaluated the relationships of affected hubs with cognitive and tremor scores in all patients and with motor function improvement scores in 15 patients who underwent postoperative follow-up evaluations after focused ultrasound thalamotomy. Results: We have identified affected connector hubs in the cerebellum and thalamus. Specifically, the dentate nucleus in the cerebellum and the dorsomedial thalamus exhibited more extensive connections with the sensorimotor network in patients. Moreover, the connections of the thalamic pulvinar with the visual network were also significantly widespread in the patient group. The connections of these connector hub regions with cognitive networks were negatively associated (FDR q < 0.05) with cognitive, tremor, and motor function improvement scores. Conclusion: In patients with essential tremor, connector hub regions within the cerebellum and thalamus exhibited widespread functional connections with sensorimotor and visual networks, leading to alternative pathways outside the classical tremor axis. Their connections with cognitive networks also affect patients’ cognitive function.

DOI： 10.1016/j.parkreldis.2024.106034

Resting-state Electroencephalography Microstates Correlate with Pain Intensity in Patients with Complex Regional Pain Syndrome 国際誌

Osumi, M; Sumitani, M; Iwatsuki, K; Hoshiyama, M; Imai, R; Morioka, S; Hirata, H

CLINICAL EEG AND NEUROSCIENCE 55 巻 ( 1 ) 頁： 121 - 129 2024年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical EEG and Neuroscience

Objective: Severe pain and other symptoms in complex regional pain syndrome (CRPS), such as allodynia and hyperalgesia, are associated with abnormal resting-state brain network activity. No studies to date have examined resting-state brain networks in CRPS patients using electroencephalography (EEG), which can clarify the temporal dynamics of brain networks. Methods: We conducted microstate analysis using resting-state EEG signals to prospectively reveal direct correlations with pain intensity in CRPS patients (n = 17). Five microstate topographies were fitted back to individual CRPS patients’ EEG data, and temporal microstate measures were subsequently calculated. Results: Our results revealed five distinct microstates, termed microstates A to E, from resting EEG data in patients with CRPS. Microstates C, D and E were significantly correlated with pain intensity before pain treatment. Particularly, microstates D and E were significantly improved together with pain alleviation after pain treatment. As microstates D and E in the present study have previously been related to attentional networks and the default mode network, improvement in these networks might be related to pain relief in CRPS patients. Conclusions: The functional alterations of these brain networks affected the pain intensity of CRPS patients. Therefore, EEG microstate analyses may be used to identify surrogate markers for pain intensity.

DOI： 10.1177/15500594231204174

Recovery of autonomic dysfunction assessed by heart rate variability after acute stroke: an observational study

複合性局所疼痛症候群患者におけるα-皮質活動の興奮-抑制バランス

岩月克之, 寶珠山稔, 佐伯総太, 徳武克浩, 米田英正, 栗本秀, 山本美知郎, 建部将広, 吉田彬人, 平田仁

末梢神経 34 巻 ( 2 ) 頁： 291 - 291 2023年12月

Connectivity alteration in thalamic nuclei and default mode network-related area in memory processes in mesial temporal lobe epilepsy using magnetoencephalography 国際誌 Open Access

Ishizaki, T; Maesawa, S; Nakatsubo, D; Yamamoto, H; Torii, J; Mutoh, M; Natsume, J; Hoshiyama, M; Saito, R

SCIENTIFIC REPORTS 13 巻 ( 1 ) 頁： 10632 - 10632 2023年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

This work aimed to investigate the involvement of the thalamic nuclei in mesial temporal lobe epilepsy (MTLE) and identify the influence of interictal epileptic discharges on the neural basis of memory processing by evaluating the functional connectivity (FC) between the thalamic nuclei and default mode network-related area (DMNRA) using magnetoencephalography. Preoperative datasets of nine patients with MTLE with seizure-free status after surgery and those of nine healthy controls were analyzed. The FC between the thalamic nuclei (anterior nucleus [ANT], mediodorsal nucleus [MD], intralaminar nuclei [IL]), hippocampus, and DMNRA was examined for each of the resting, pre-spike, spike, and post-spike periods in the delta to ripple bands using magnetoencephalography. The FC between the ANT, MD, hippocampus, and medial prefrontal cortex increased in the gamma to ripple bands, whereas the FC between the ANT, IL, and DMNRA decreased in the delta to beta bands, compared with that of the healthy controls at rest. Compared with the rest period, the pre-spike period had significantly decreased FC between the ANT, MD, and DMNRA in the ripple band. Different FC changes between the thalamic nuclei, hippocampus, and DMNRA of specific connections in a particular band may reflect impairment or compensation in the memory processes.

DOI： 10.1038/s41598-023-37834-2

Hoshino, T; Oguchi, K; Hoshino, A; Hoshiyama, M

INTERNATIONAL JOURNAL OF THERAPY AND REHABILITATION 30 巻 ( 6 ) 頁： 1 - 11 2023年6月

掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Therapy and Rehabilitation

Background/aims Early mobilisation after acute stroke is recommended worldwide, and autonomic dysfunction is a common complication. However, little is known about autonomic adaptation to postural changes during early mobilisation. The aim of the present study was to clarify the recovery process of autonomic dysfunction after acute stroke regarding adaptation to postural changes. Methods A total of 23 patients (mean age 60 ± 11 years) were included in this observational study. Those with a history of arrhythmia, heart failure and diabetes mellitus with diabetic neuropathy were excluded. Autonomic functions were assessed using heart rate variability. Electrocardiograms were recorded when the patients were lying down, sitting up and then lying back down again for 5 minutes in each position. The indices of heart rate variability, total power, high frequency band and low frequency/high frequency ratio, which correspond to total, parasympathetic and sympathetic activity respectively, were calculated to evaluate participants’ autonomic function during the 7 days after the onset of stroke. Results From days 3 to 7 after stroke onset, the low frequency/high frequency ratio was significantly higher, and the total power and high frequency were reciprocally lower in the sitting position than in the supine position. On day 7, the total power and high frequency were significantly higher while the low frequency/high frequency ratio was lower than the total power and high frequency values that were recorded on the second and third days after stroke. Blood pressure levels and heart rates also changed, corresponding to changes in heart rate variability. conclusions The patients’ autonomic function, as well as heart rate and blood pressure levels, changed gradually during the first 7 days after onset of stroke. The results could lead to optimised clinical practice in safe early stroke rehabilitation.

DOI： 10.12968/ijtr.2021.0033

Relationship Between Psychological Factors and Wound Occurrence in Patients With Peripheral Arterial Disease in the Leg 国際誌

慢性疼痛患者と複合性局所疼痛症候群患者における脳可塑性の変化の比較

岩月克之, 寳珠山稔, 徳武克浩, 米田英正, 栗本秀, 山本美知郎, 建部将広, 平田仁

日本手外科学会雑誌 40 巻 ( 1 ) 頁： O50 - 6 2023年4月

Onoyama, A; Hoshiyama, M; Yabe, H

INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS 21 巻 ( 3 ) 頁： 312 - 319 2022年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Lower Extremity Wounds

This prospective study investigated psychological factors affecting wound healing in patients with peripheral arterial disease (PAD). Fifty patients with PAD in a local hospital were enrolled. The Geriatric Depression Scale short version, Type-D scale 14, Medical Outcome Study 36-Item Short-Form Health Survey (SF-36), Functional Independence Measure, Self-efficacy for Managing Chronic Disease Scale, Barriers Self-Efficacy Scale, and Mini Nutritional Assessment were applied to assess physical and psychological factors. Wound occurrence and healing were evaluated at 6 months after discharge, and 34 and 30 patients could be followed, respectively. The patient group with wound occurrence showed poorer mental component score (MCS) and better role/social component score (RCS) category scores of SF-36, and a higher stage in the Fontaine classification, than those without wound occurrence. On comparing Fontaine classification–matched subgroups, patients with wound occurrence showed poorer general health factor and MCS and better RCS of SF-36 than those without wound occurrence. Logistic analysis showed that MCS and RCS predicted wound occurrence and needs for local medical treatment, respectively. Among the psychological factors tested, MCS was a major factor associated with wound occurrence in the present study, with wide variation in clinical conditions and factors associated with PAD. Psychological factors were important as biological, physical, and social factors for patients with PAD during the long-term follow-up period, and an appropriate battery to evaluate psychological factors focused on patients with PAD should be developed.

DOI： 10.1177/1534734620943813

特集運動器慢性疼痛の病態と治療慢性疼痛と脳神経活動

Functional connector hubs in the cerebellum 国際誌 Open Access

Kawabata, K; Bagarinaob, E; Watanabe, H; Maesawab, S; Mori, D; Hara, K; Ohdake, R; Masuda, M; Ogura, A; Kato, T; Koyama, S; Katsuno, M; Wakabayashi, T; Kuzuya, M; Hoshiyama, M; Isoda, H; Naganawa, S; Ozaki, N; Sobue, G

NEUROIMAGE 257 巻頁： 119263 - 119263 2022年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NeuroImage

Accumulating evidence from anatomical and neuroimaging studies suggests that the cerebellum is engaged in a variety of motor and cognitive tasks. Given its various functions, a key question is whether the cerebellum also plays an important role in the brain's integrative functions. Here, we hypothesize the existence of connector regions, also known as connector hubs, where multiple resting state networks converged in the cerebellum. To verify this, we employed a recently developed voxel-level network measure called functional connectivity overlap ratio (FCOR), which could be used to quantify the spatial extent of a region's connection to several large-scale cortical networks. Using resting state functional MRI data from 101 healthy participants, cerebellar FCOR maps were constructed and used to identify the locations of connector hubs in the cerebellum. Results showed that a number of cerebellar regions exhibited strong connectivity with multiple functional networks, verifying our hypothesis. These highly connected regions were located in the posterior cerebellum, especially in lobules VI, VII, and IX, and mainly connected to the core neurocognitive networks such as default mode and executive control networks. Regions associated with the sensorimotor network were also localized in lobule V, VI, and VIII, albeit in small clusters. These cerebellar connector hubs may play an essential role in the processing of information across the core neurocognitive networks.

DOI： 10.1016/j.neuroimage.2022.119263

寳珠山稔

関節外科　基礎と臨床 41 巻 ( 7 ) 頁： 717 - 721 2022年7月

記述言語：日本語出版者・発行元：メジカルビュー社

＜文献概要＞慢性疼痛を生じている状態では,疼痛に関連する感覚系に変化が生じているばかりではなく広範囲の脳領域に影響が及んでいる。疼痛の認識は,侵害刺激によって生じる一方,脳の基本活動を決定する複数の神経ネットワークやネットワーク相互の変化によって形成されている可能性がある。それらは感覚・運動機能や認知機能,自律神経活動や自己表出などにさまざまな程度で影響を及ぼし,合併症としての機能障害を生じると考えられる。

DOI： 10.18885/jjs.0000001055

CiNii Research

注意機能の変化をみる段階的作業課題とその利用—─課題達成度の変化からみた注意機能の改善プロセスと臨床的推論─

谷利美希, 寳珠山稔

作業療法 41 巻 ( 1 ) 頁： 94 - 105 2022年2月

記述言語：日本語出版者・発行元：一般社団法人日本作業療法士協会

注意機能をスクリーニングし，日常生活活動能力の予後予測を含めた臨床的推論を簡易的に行うため，注意障害の病態に基づいて段階づけた課題を設定した．本研究は，設定した課題達成度の変化を観察し，既存の評価との関連性を検証した．対象は発症2ヵ月以内に入院した脳卒中患者14名とした．結果，対象者の課題達成度および評価得点は有意に向上し，課題達成度と神経心理学的検査および日常生活動作能力には有意な相関が認められた．本研究で設定した課題の達成段階を目安にして，注意機能の改善プロセスを概観し，日常生活活動の達成度を推察できる可能性が示唆され，対象者の注意機能に合わせた課題や場面設定をすることが可能と考えられた．

DOI： 10.32178/jotr.41.1_94

CiNii Books

CiNii Research

Reserve and Maintenance in the Aging Brain: A Longitudinal Study of Healthy Older Adults 国際誌 Open Access

Bagarinao, E; Watanabe, H; Maesawa, S; Kawabata, K; Hara, K; Ohdake, R; Ogura, A; Mori, D; Yoneyama, N; Imai, K; Yokoi, T; Kato, T; Koyama, S; Katsuno, M; Wakabayashi, T; Kuzuya, M; Hoshiyama, M; Isoda, H; Naganawa, S; Ozaki, N; Sobue, G

ENEURO 9 巻 ( 1 ) 2022年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：eNeuro

The aging brain undergoes structural changes even in very healthy individuals. Quantifying these changes could help disentangle pathologic changes from those associated with the normal human aging process. Using longitudinal magnetic resonance imaging (MRI) data from 227 carefully selected healthy human cohort with age ranging from 50 to 80 years old at baseline scan, we quantified age-related volumetric changes in the brain of healthy human older adults. Longitudinally, the rates of tissue loss in total gray matter (GM) and white matter (WM) were 2497.5 and 2579.8 mm3 per year, respectively. Across the whole brain, the rates of GM decline varied with regions in the frontal and parietal lobes having faster rates of decline, whereas some regions in the occipital and temporal lobes appeared relatively preserved. In contrast, cross-sectional changes were mainly observed in the temporal-occipital regions. Similar longitudinal atrophic changes were also observed in subcortical regions including thalamus, hippocampus, putamen, and caudate, whereas the pallidum showed an increasing volume with age. Overall, regions maturing late in development (frontal, parietal) are more vulnerable to longitudinal decline, whereas those that fully mature in the early stage (temporal, occipital) are mainly affected by cross-sectional changes in healthy older cohort. This may suggest that, for a successful healthy aging, the former needs to be maximally developed at an earlier age to compensate for the longitudinal decline later in life and the latter to remain relatively preserved even in old age, consistent with both concepts of reserve and brain maintenance.

DOI： 10.1523/ENEURO.0455-21.2022

Relationship between lower limb function and functional connectivity assessed by EEG among motor-related areas after stroke 国際誌

Hoshino, T; Oguchi, K; Inoue, K; Hoshino, A; Hoshiyama, M

TOPICS IN STROKE REHABILITATION 28 巻 ( 8 ) 頁： 614 - 623 2021年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Topics in Stroke Rehabilitation

Background: Neural connectivity in brain has been known as indicators for neural function and recovery of brain. Although previous studies reported that neural connectivity predicted the recovery of upper limb function after stroke, the relationship between neural connectivity and lower limb function has not been clear. Objectives: To clarify whether functional connectivity (FC) assessed by electroencephalographiy (EEG) with five electrodes placed on motor-related areas could be related to the functional motor recovery of the lower limbs in patients after stroke. Methods: Twenty-four patients with stroke during the recovery phase were recruited. Motor function of the lower limbs was assessed using Fugl-Meyer Assessment lower limb section (FMAL). EEG signals were recorded by five electrodes (C3, C4, FC3, FC4, and FCz) at rest and during ankle movement. Amplitude envelope correlations, as values for FC, were calculated in α (8–12 Hz), β (13–30 Hz), low-β (13–19 Hz), and high-β (20–30 Hz) frequency bands. The predictive regression equation of the FMAL score in the eighth week after stroke (8 W) was created by FCs in the fourth week (4 W). Results: The higher intra-hemispheric FC in both hemispheres in the resting state and during the ankle movement at 4 W was related to a higher lower limb function at 8 W. Additionally, the higher inter-hemispheric FC between M1 on both sides during the ankle movement was related to a higher function recovery. Conclusions: The intra- and inter-hemispheric FC among motor-related areas at 4 W after stroke might be related to the functional recovery of the lower limbs at 8 W.

DOI： 10.1080/10749357.2020.1864986