研究者詳細 - 寳珠山　稔

論文 - 寳珠山　稔

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Resting State Networks Related to the Maintenance of Good Cognitive Performance During Healthy Aging 国際誌 Open Access

Maesawa, S; Mizuno, S; Bagarinao, E; Watanabe, H; Kawabata, K; Hara, K; Ohdake, R; Ogura, A; Mori, D; Nakatsubo, D; Isoda, H; Hoshiyama, M; Katsuno, M; Saito, R; Ozaki, N; Sobue, G

FRONTIERS IN HUMAN NEUROSCIENCE 15 巻頁： 753836 - 753836 2021年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Frontiers in Human Neuroscience

Purpose: Maintenance of cognitive performance is important for healthy aging. This study aims to elucidate the relationship between brain networks and cognitive function in subjects maintaining relatively good cognitive performance. Methods: A total of 120 subjects, with equal number of participants from each age group between 20 and 70 years, were included in this study. Only participants with Addenbrooke’s Cognitive Examination – Revised (ACE-R) total score greater than 83 were included. Anatomical T1-weighted MR images and resting-state functional MR images (rsfMRIs) were taken from all participants using a 3-tesla MRI scanner. After preprocessing, several factors associated with age including the ACE-R total score, scores of five domains, sub-scores of ACE-R, and brain volumes were tested. Morphometric changes associated with age were analyzed using voxel based morphometry (VBM) and changes in resting state networks (RSNs) were examined using dual regression analysis. Results: Significant negative correlations with age were seen in the total gray matter volume (GMV, r = −0.58), and in the memory, attention, and visuospatial domains. Among the different sub-scores, the score of the delayed recall (DR) showed the highest negative correlation with age (r = −0.55, p < 0.001). In VBM analysis, widespread regions demonstrated negative correlation with age, but none with any of the cognitive scores. Quadratic approximations of cognitive scores as functions of age showed relatively delayed decline compared to total GMV loss. In dual regression analysis, some cognitive networks, including the dorsal default mode network, the lateral dorsal attention network, the right / left executive control network, the posterior salience network, and the language network, did not demonstrate negative correlation with age. Some regions in the sensorimotor networks showed positive correlation with the DR, memory, and fluency scores. Conclusion: Some domains of the cognitive test did not correlate with age, and even the highly correlated sub-scores such as the DR score, showed delayed decline compared to the loss of total GMV. Some RSNs, especially involving cognitive control regions, were relatively maintained with age. Furthermore, the scores of memory, fluency, and the DR were correlated with the within-network functional connectivity values of the sensorimotor network, which supported the importance of exercise for maintenance of cognition.

DOI： 10.3389/fnhum.2021.753836

Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus 国際誌 Open Access

Kawabata, K; Bagarinao, E; Watanabe, H; Maesawa, S; Mori, D; Hara, K; Ohdake, R; Masuda, M; Ogura, A; Kato, T; Koyama, S; Katsuno, M; Wakabayashi, T; Kuzuya, M; Hoshiyama, M; Isoda, H; Naganawa, S; Ozaki, N; Sobue, G

ISCIENCE 24 巻 ( 10 ) 頁： 103106 - 103106 2021年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：iScience

The thalamus is critical for the brain's integrative hub functions; however, the localization and characterization of the different thalamic hubs remain unclear. Using a voxel-level network measure called functional connectivity overlap ratio (FCOR), we examined the thalamus' association with large-scale resting-state networks (RSNs) to elucidate its connector hub roles. Connections to the core-neurocognitive networks were localized in the anterior and medial parts, such as the anteroventral and mediodorsal nuclei areas. Regions functionally connected to the sensorimotor network were distinctively located around the lateral pulvinar nucleus but to a limited extent. Prominent connector hubs include the anteroventral, ventral lateral, and mediodorsal nuclei with functional connections to multiple RSNs. These findings suggest that the thalamus, with extensive connections to most of the RSNs, is well placed as a critical integrative functional hub and could play an important role for functional integration facilitating brain functions associated with primary processing and higher cognition.

DOI： 10.1016/j.isci.2021.103106

Pre-stimulus alpha oscillation and post-stimulus cortical activity differ in localization between consciously perceived and missed near-threshold somatosensory stimuli 国際誌 Open Access

Uemura, J; Hoshino, A; Igarashi, G; Matsui, Y; Chishima, M; Hoshiyama, M

EUROPEAN JOURNAL OF NEUROSCIENCE 54 巻 ( 4 ) 頁： 5518 - 5530 2021年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Journal of Neuroscience

Conscious perception of a near-threshold (NT) stimulus is characterized by the pre- and post-stimulus brain state. However, the power of pre-stimulus neural oscillations and strength of post-stimulus cortical activity that lead to conscious perception have rarely been examined in individual cortical areas. This is because most previous electro- and magnetoencephalography (EEG and MEG, respectively) studies involved scalp- and sensor-level analyses. Therefore, we recorded MEG during a continuous NT somatosensory stimulus detection task and applied the reconstructed source data in order to identify cortical areas where the post-stimulus cortical activity and pre-stimulus alpha oscillation predict the conscious perception of NT somatosensory stimuli. We found that the somatosensory hierarchical processing areas, prefrontal areas and cortical areas belonging to the default mode network showed stronger cortical activity for consciously perceived trials in the post-stimulus period, but the cortical activity in primary somatosensory area (SI) is independent of conscious perception during the early stage of NT stimulus processing. In addition, we revealed that the pre-stimulus alpha oscillation only in SI is predictive of conscious perception. These findings suggest that the bottom-up stream of somatosensory information flow following SI and pre-stimulus alpha activity fluctuation in SI as a top-down modulation are crucial constituents of conscious perception.

DOI： 10.1111/ejn.15388

Web of Science

Scopus

PubMed

Iwatsuki, K; Hoshiyama, M; Yoshida, A; Uemura, J; Hoshino, A; Morikawa, I; Nakagawa, Y; Hirata, H

IBRO NEUROSCIENCE REPORTS 10 巻 ( 1 ) 頁： 208 - 215 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：IBRO Neuroscience Reports

Quantitative objective measurement of chronic pain is important. We elucidated chronic pain-related cortical neural activity and neural connectivity among pain-related brain regions in complex regional pain syndrome (CRPS). Resting-state magnetoencephalography recordings were performed. Cortical current density and neural connectivity, revealed by amplitude envelope correlation (AEC), were estimated on standardized brain magnetic resonance imaging. Intra-experiment pain was assessed subjectively using a visual analogue scale (VAS). The correlation between current density and VAS scores was calculated for the occipital areas and pain-related cortices. Current density in the primary (SI) and secondary (SII) somatosensory cortex and precuneus in both hemispheres was negatively correlated with the pain VAS score. The AEC and VAS values were significantly correlated for the SII and the precuneus and for the SII and insular cortex in the alpha frequency band in the right hemisphere. In the theta frequency band, the AEC and VAS values correlated for the SII and posterior cingulate cortex in the right hemisphere. Our results suggested that disruption of pain processes and functions in the default mode network occurs in CRPS. Our method targeting the neural mechanism of pain has the potential to offer a clinically objective means of evaluating it.

DOI： 10.1016/j.ibneur.2021.05.001

寳珠山稔

PAIN RESEARCH 36 巻 ( 1 ) 頁： 42 - 48 2021年4月

記述言語：日本語出版者・発行元：日本疼痛学会

慢性疼痛を有する状態における大脳活動、特に大脳皮質神経活動に焦点を当ててこれまでの知見と自験例を提示して慢性疼痛における大脳皮質の特徴的活動について、以下の項目に分けて考察した。1)慢性疼痛患者における脳の神経活動の観察、2)慢性疼痛の客観的指標としての脳活動計測、3)脳機能計測を用いた慢性疼痛評価の問題点、4)自験例による慢性疼痛と皮質活動の計測、5)慢性疼痛の客観的評価手法としての脳活動測定、について述べた。

DOI： 10.11154/pain.36.42

CiNii Research

その他リンク： https://search.jamas.or.jp/link/ui/2021241998

Effects of Head Motion on the Evaluation of Age-related Brain Network Changes Using Resting State Functional MRI Open Access

Kato, S; Bagarinao, E; Isoda, H; Koyama, S; Watanabe, H; Maesawa, S; Mori, D; Hara, K; Katsuno, M; Hoshiyama, M; Naganawa, S; Ozaki, N; Sobue, G

MAGNETIC RESONANCE IN MEDICAL SCIENCES 20 巻 ( 4 ) 頁： 338 - 346 2021年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：日本磁気共鳴医学会

Purpose: The estimation of functional connectivity (FC) measures using resting state functional MRI (fMRI) is often affected by head motion during functional imaging scans. Head motion is more common in the elderly than in young participants and could therefore affect the evaluation of age-related changes in brain networks. Thus, this study aimed to investigate the influence of head motion in FC estimation when evaluating age-related changes in brain networks. Methods: This study involved 132 healthy volunteers divided into 3 groups: elderly participants with high motion (OldHM, mean age (±SD) = 69.6 (±5.31), N = 44), elderly participants with low motion (OldLM, mean age (±SD) = 68.7 (±4.59), N = 43), and young adult participants with low motion (YugLM, mean age (±SD) = 27.6 (±5.26), N = 45). Head motion was quantified using the mean of the framewise displacement of resting state fMRI data. After preprocessing all resting state fMRI datasets, several resting state networks (RSNs) were extracted using independent component analysis (ICA). In addition, several network metrics were also calculated using network analysis. These FC measures were then compared among the 3 groups. Results: In ICA, the number of voxels with significant differences in RSNs was higher in YugLM vs. OldLM comparison than in YugLM vs. OldHM. In network analysis, all network metrics showed significant (P < 0.05) differences in comparisons involving low vs. high motion groups (OldHM vs. OldLM and OldHM vs. YugLM). However, there was no significant (P > 0.05) difference in the comparison involving the low motion groups (OldLM vs. YugLM). Conclusion: Our findings showed that head motion during functional imaging could significantly affect the evaluation of age-related brain network changes using resting state fMRI data.

DOI： 10.2463/mrms.mp.2020-0081

安静時および運動時のfunctional connectivityの変化による脳卒中後の上肢機能の予後予測

星野高志, 小口和代, 井上健二, 寳珠山稔

理学療法学Supplement 48S1 巻 ( 0 ) 頁： C-181_1 - C-181_1 2021年

Identifying the brain's connector hubs at the voxel level using functional connectivity overlap ratio 国際誌 Open Access

Bagarinao, E; Watanabe, H; Maesawa, S; Mori, D; Hara, K; Kawabata, K; Ohdake, R; Masuda, M; Ogura, A; Kato, T; Koyama, S; Katsuno, M; Wakabayashi, T; Kuzuya, M; Hoshiyama, M; Isoda, H; Naganawa, S; Ozaki, N; Sobue, G

NEUROIMAGE 222 巻頁： 117241 - 117241 2020年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NeuroImage

Neuroimaging studies have shown that the brain is functionally organized into several large-scale brain networks. Within these networks are regions that are widely connected to several other regions within and/or outside the network. Regions that connect to several other networks, known as connector hubs, are believed to be crucial for information transfer and between-network communication within the brain. To identify regions with high between-network connectivity at the voxel level, we introduced a novel metric called functional connectivity overlap ratio (FCOR), which quantifies the spatial extent of a region's connection to a given network. Using resting state functional magnetic resonance imaging data, FCOR maps were generated for several well-known large-scale resting state networks (RSNs) and used to examine the relevant associations among different RSNs, identify connector hub regions in the cerebral cortex, and elucidate the hierarchical functional organization of the brain. Constructed FCOR maps revealed a strong association among the core neurocognitive networks (default mode, salience, and executive control) as well as among primary processing networks (sensorimotor, auditory, and visual). Prominent connector hubs were identified in the bilateral middle frontal gyrus, posterior cingulate, lateral parietal, middle temporal, dorsal anterior cingulate, and anterior insula, among others, regions mostly associated with the core neurocognitive networks. Finally, clustering the whole brain using FCOR features yielded a topological organization that arranges brain regions into a hierarchy of information processing systems with the primary processing systems at one end and the heteromodal systems comprising connector hubs at the other end.

DOI： 10.1016/j.neuroimage.2020.117241

その他リンク： https://dblp.uni-trier.de/db/journals/neuroimage/neuroimage222.html#BagarinaoWMMHKO20

Aging Impacts the Overall Connectivity Strength of Regions Critical for Information Transfer Among Brain Networks 国際誌 Open Access

Bagarinao, E; Watanabe, H; Maesawa, S; Mori, D; Hara, K; Kawabata, K; Yoneyama, N; Ohdake, R; Imai, K; Masuda, M; Yokoi, T; Ogura, A; Taoka, T; Koyama, S; Tanabe, HC; Katsuno, M; Wakabayashi, T; Kuzuya, M; Hoshiyama, M; Isoda, H; Naganawa, S; Ozaki, N; Sobue, G

FRONTIERS IN AGING NEUROSCIENCE 12 巻頁： 592469 - 592469 2020年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Frontiers in Aging Neuroscience

Recent studies have demonstrated that connector hubs, regions considered critical for the flow of information across neural systems, are mostly involved in neurodegenerative dementia. Considering that aging can significantly affect the brain’s intrinsic connectivity, identifying aging’s impact on these regions’ overall connection strength is important to differentiate changes associated with healthy aging from neurodegenerative disorders. Using resting state functional magnetic resonance imaging data from a carefully selected cohort of 175 healthy volunteers aging from 21 to 86 years old, we computed an intrinsic connectivity contrast (ICC) metric, which quantifies a region’s overall connectivity strength, for whole brain, short-range, and long-range connections and examined age-related changes of this metric over the adult lifespan. We have identified a limited number of hub regions with ICC values that showed significant negative relationship with age. These include the medial precentral/midcingulate gyri and insula with both their short-range and long-range (and thus whole-brain) ICC values negatively associated with age, and the angular, middle frontal, and posterior cingulate gyri with their long-range ICC values mainly involved. Seed-based connectivity analyses further confirmed that these regions are connector hubs with connectivity profile that strongly overlapped with multiple large-scale brain networks. General cognitive performance was not associated with these hubs’ ICC values. These findings suggest that even healthy aging could negatively impact the efficiency of regions critical for facilitating information transfer among different functional brain networks. The extent of the regions involved, however, was limited.

DOI： 10.3389/fnagi.2020.592469

健常者における安静時脳磁図ネットワークの加齢性変化

加藤隼康, 渡辺宏久, 大嶽れい子, 小倉礼, 川畑和也, 桝田道人, 原一洋, 寶珠山稔, 勝野雅央, 祖父江元

臨床神経生理学 48 巻 ( 5 ) 頁： 537 - 537 2020年10月

Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis 国際誌 Open Access

Choy, SW; Bagarinao, E; Watanabe, H; Ho, ETW; Maesawa, S; Mori, D; Hara, K; Kawabata, K; Yoneyama, N; Ohdake, R; Imai, K; Masuda, M; Yokoi, T; Ogura, A; Taoka, T; Koyama, S; Tanabe, HC; Katsuno, M; Wakabayashi, T; Kuzuya, M; Hoshiyama, M; Isoda, H; Naganawa, S; Ozaki, N; Sobue, G

HUMAN BRAIN MAPPING 41 巻 ( 12 ) 頁： 3198 - 3211 2020年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Human Brain Mapping

White matter (WM) fiber bundles change dynamically with age. These changes could be driven by alterations in axonal diameter, axonal density, and myelin content. In this study, we applied a novel fixel-based analysis (FBA) framework to examine these changes throughout the adult lifespan. Using diffusion-weighted images from a cohort of 293 healthy volunteers (89 males/204 females) from ages 21 to 86 years old, we performed FBA to analyze age-related changes in microscopic fiber density (FD) and macroscopic fiber morphology (fiber cross section [FC]). Our results showed significant and widespread age-related alterations in FD and FC across the whole brain. Interestingly, some fiber bundles such as the anterior thalamic radiation, corpus callosum, and superior longitudinal fasciculus only showed significant negative relationship with age in FD values, but not in FC. On the other hand, some segments of the cerebello-thalamo-cortical pathway only showed significant negative relationship with age in FC, but not in FD. Analysis at the tract-level also showed that major fiber tract groups predominantly distributed in the frontal lobe (cingulum, forceps minor) exhibited greater vulnerability to the aging process than the others. Differences in FC and the combined measure of FD and cross section values observed between sexes were mostly driven by differences in brain sizes although male participants tended to exhibit steeper negative linear relationship with age in FD as compared to female participants. Overall, these findings provide further insights into the structural changes the brain's WM undergoes due to the aging process.

DOI： 10.1002/hbm.25008

Apathy and depression during the recovery stage after stroke

Kawasaki, M; Hoshiyama, M

INTERNATIONAL JOURNAL OF THERAPY AND REHABILITATION 27 巻 ( 5 ) 頁： 1 - 12 2020年5月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Therapy and Rehabilitation

Background/Aims Both apathy and depression occur during the recovery period following stroke; however, the relationship between post-stroke apathy and depression is still unclear. The present study investigated the clinical course of apathy and its association with depression, cognitive function and daily function during the recovery period after stroke. Methods A total of 42 patients (29 male and 13 female, aged 69.1 ± 12.4 years) who had experienced stroke participated in this study. Each participant was assessed using the Apathy Scale, Self-rating Depression Scale, Mini-Mental State Examination, Clinical Assessment of Attention and Trail-Making-Test parts A and B. Quality of life was evaluated using the Stroke Specific Quality of Life Scale. Physical function and functional status were assessed using the Brunnstrom Stages of Stroke Recovery and Functional Independence Measure respectively. Results The incidence of apathy did not change from the time of admission to discharge. Apathy Scale score did not correlate with Self-rating Depression Scale score at admission, but it did correlate at the time of discharge. Patients with apathy after stroke suffered from greater cognitive disturbance and attention and executive dysfunctions than those without apathy. Total Functional Independence Measure score did not correlate with Apathy Scale or Self-rating Depression Scale score, but there was an association between Self-rating Depression Scale score and the Functional Independence Measure motor and Brunnstrom scores at discharge. Conclusions Apathy and depression had different relationships with cognitive and physical function during the recovery stage after stroke. The prevalence of apathy and depression changed, with the interrelationship between apathy and depression altering during the recovery period. Symptoms of apathy and depression should be distinguished from each other and appropriately evaluated to provide effective intervention to support physical and mental recovery after stroke.

DOI： 10.12968/ijtr.2018.0070

Web of Science

Scopus

Subsecond EEG-fMRI analysis for presurgical evaluation in focal epilepsy 国際誌 Open Access

Ito, Y; Maesawa, S; Bagarinao, E; Okai, Y; Nakatsubo, D; Yamamoto, H; Kidokoro, H; Usui, N; Natsume, J; Hoshiyama, M; Wakabayashi, T; Sobue, G; Ozaki, N

JOURNAL OF NEUROSURGERY 134 巻 ( 4 ) 頁： 1027 - 1036 2020年4月

記述言語：英語出版者・発行元：Journal of Neurosurgery

OBJECTIVE The authors recently reported a novel subsecond analysis method of analyzing EEG–functional MRI (fMRI) to improve the detection rate of epileptic focus. This study aims to validate the utility of this method for presurgical evaluation in pharmacoresistant focal epilepsy. METHODS Among 13 patients with focal epilepsy undergoing presurgical examinations including simultaneous EEG-fMRI at 3T, 11 patients had interictal epileptiform discharges (IEDs) during fMRI. The authors used the sequence of topographic maps during the IEDs as a reference to obtain subsecond fMRI activation maps with the same temporal resolution as the EEG data, and constructed “spike-and-slow-wave-activation-summary” (SSWAS) maps that showed the activation frequency of voxels during IEDs. Clusters were defined by thresholding the SSWAS maps (voxel value > 10), and those containing voxels with the top 3 highest activation frequencies were considered significant. Significant hemodynamic responses using conventional event-related (ER) analysis and SSWAS maps were compared with the resection areas and surgical outcomes at 1 year after surgery. RESULTS Using ER analysis, 4 (36%) of 11 patients had significant hemodynamic responses. One of 4 patients had significant hemodynamic responses in the resection area and good surgical outcome. Using SSWAS maps, 10 (91%) of 11 patients had significant hemodynamic responses. Six of 10 patients had significant hemodynamic responses in the resection area, and 5 of the 6 patients achieved good surgical outcomes. The remaining 4 patients had significant hemodynamic responses distant from the resection area, and only 1 of the 4 patients achieved good surgical outcomes. The sensitivity, specificity, positive predictive value, and negative predictive value of SSWAS maps were 83.3%, 75.0%, 83.3%, and 75.0%, respectively. CONCLUSIONS This study demonstrated the clinical utility of SSWAS maps for presurgical evaluation of pharmacoresistant focal epilepsy. The findings indicated that subsecond EEG-fMRI analysis may help surgeons choose the resection areas that could lead to good surgical outcomes.

DOI： 10.3171/2020.1.JNS192567

Web of Science

Scopus

PubMed

y Distributed source analysis of magnetoencephalography using a volume head model combined with statistical methods improves focus diagnosis in epilepsy surgery 国際誌 Open Access

Ishizaki, T; Maesawa, S; Nakatsubo, D; Yamamoto, H; Takai, S; Shibata, M; Kato, S; Natsume, J; Hoshiyama, M; Wakabayashi, T

SCIENTIFIC REPORTS 10 巻 ( 1 ) 頁： 5263 - 5263 2020年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Deep-seated epileptic focus estimation using magnetoencephalography is challenging because of its low signal-to-noise ratio and the ambiguity of current sources estimated by interictal epileptiform discharge (IED). We developed a distributed source (DS) analysis method using a volume head model as the source space of the forward model and standardized low-resolution brain electromagnetic tomography combined with statistical methods (permutation tests between IEDs and baselines and false discovery rate between voxels to reduce variation). We aimed to evaluate the efficacy of the combined DS (cDS) analysis in surgical cases. In total, 19 surgical cases with adult and pediatric focal epilepsy were evaluated. Both cDS and equivalent current dipole (ECD) analyses were performed in all cases. The concordance rates of the two methods with surgically identified epileptic foci were calculated and compared with surgical outcomes. Concordance rates from the cDS analysis were significantly higher than those from the ECD analysis (68.4% vs. 26.3%), especially in cases with deep-seated lesions, such as in the interhemispheric, fronto-temporal base, and mesial temporal structures (81.8% vs. 9.1%). Furthermore, the concordance rate correlated well with surgical outcomes. In conclusion, cDS analysis has better diagnostic performance in focal epilepsy, especially with deep-seated epileptic focus, and potentially leads to good surgical outcomes.

DOI： 10.1038/s41598-020-62098-5

手根管開放術前後における脳機能変化

岩月克之, 寶珠山稔, 篠原孝明, 吉田彬人, 大山慎太郎, 米田英正, 石井久雄, 栗本秀, 山本美知郎, 建部将広, 平田仁

日本整形外科学会雑誌 94 巻 ( 3 ) 頁： S1077 - S1077 2020年3月

Electroencephalographic Functional Connectivity With the Tacit Learning System Prosthetic Hand: A Case Series Using Motor Imagery

Iwatsuki Katsuyuki, Hoshiyama Minoru, Oyama Shintaro, Yoneda Hidemasa, Shimoda Shingo, Hirata Hitoshi

FRONTIERS IN SYNAPTIC NEUROSCIENCE 12 巻頁： 7 2020年2月

Electroencephalographic Functional Connectivity with the Tacit Learning System Prosthetic Hand: a case series using motor imagery 査読有り

Katsuyuki Iwatsuki, Minoru Hoshiyama, Shintaro Oyama, Hidemasa Yoneda, Shingo Shimoda, Hitoshi Hirata

Front. Synaptic Neurosci. 2020年2月

Relationship between upper limb function and functional neural connectivity among motor related-areas during recovery stage after stroke 国際誌

Hoshino, T; Oguchi, K; Inoue, K; Hoshino, A; Hoshiyama, M

TOPICS IN STROKE REHABILITATION 27 巻 ( 1 ) 頁： 57 - 66 2020年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Topics in Stroke Rehabilitation

Backgrounds: Neural biomarkers to predict motor recovery have been used in the field of rehabilitation. Functional connectivity (FC) among the brain regions recorded by functional magnetic resonance imaging systems have been reported, but convenient method to estimate FC for clinical situation has not been established. Objectives: This observational study investigated the relationship between neural functional connectivity obtained by electroencephalography (EEG) and the upper limb function in patients during recovery stage after stroke. Methods: Twenty-four patients in the recovery stage between 4 and 8 weeks after the onset of stroke (mean age: 62 ± 12 (SD)) were enrolled. The EEG signals were obtained by five electrodes placed on the motor-related areas (C3, C4, FC3, FC4, and FCz in the International 10–20 system) for 60 sec at rest and during finger movement on the affected side, and amplitude envelope correlations as measures of FC among the areas were calculated. Fugl-Meyer Assessment (FMA) was used to assess upper limb motor function. Results: The FMA scores evaluated at 4W (33 ± 24 (SD)) were improved by 8W (42 ± 23) (p <.001). The FCs in α and β bands calculated between the electrodes in the ipsi-lesional hemisphere were correlated negatively with the FMA score at 4W after stroke. The FCs obtained at 4W could be used to predict the FMA score at 8W after stroke. Conclusions: The FCs recorded at rest, as well as during the finger motor task, by the five electrodes placed on motor-related areas could be used to predict the motor function and recovery of the upper limb affected by stroke. The results indicate the possibility of using FCs recorded by conventional EEG with electrodes as biomarkers to predict motor recovery after stroke.

DOI： 10.1080/10749357.2019.1658429

Web of Science

Scopus

PubMed

FDG-PETとEEG-fMRIを用いててんかん焦点、てんかん性ネットワークの継時的評価を行った結節性硬化症の1例

牧祐輝, 伊藤祐史, 岡井佑, 白木杏奈, 川口将宏, 鈴木健史, 田中雅大, 坂口陽子, 山本啓之, 中田智彦, 城所博之, 前澤聡, バガリナオ・エピファニオ, 寳珠山稔, 夏目淳

てんかん研究 37 巻 ( 3 ) 頁： 838 - 838 2020年1月

Disturbance of somatotopic spatial cognition and extra-territorial pain in carpal tunnel syndrome 国際誌

Yoshida, A; Iwatsuki, K; Hoshiyama, M; Hirata, H

NEUROREHABILITATION 46 巻 ( 3 ) 頁： 423 - 431 2020年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NeuroRehabilitation

BACKGROUND: Several studies on carpal tunnel syndrome have reported pain that exists beyond the median nerve territory of the affected hand. However, the mechanism is unknown. PURPOSE: We investigated the cause of extra-territorial pain by the analysis of clinical assessments and cortical activity using magnetoencephalography. METHODS: To compare patients with and without extra-territorial pain, fourteen patients with carpal tunnel syndrome were assessed using clinical examination, such as patients' profile, paresthesia, physical tests, and psychological tests. The physical assessment included tactile threshold and static and moving two-point discrimination sensations on digital pulp. Neural activation in the cerebral cortex was also measured using z-scores calculated by magnetoencephalography. RESULTS: Among fourteen patients, ten patients had pain in the affected median nerve territory only and four patients had extra-territorial pain. When comparing the groups, the static and moving two-point discrimination sensation values in patients with extra-territorial pain were larger than those of patients without the pain (p<0.05). The supra-marginal gyrus, mid-part of the precentral sulcus, angular gyrus in the left hemisphere, bilateral sensorimotor areas for legs, and bilateral isthmus-cingulate areas showed larger z-scores in patients with extra-territorial pain than in patients without the pain (p<0.05). CONCLUSIONS: The static and moving two-point discrimination sensations signify the ability of tactile spatial acuity. Bilateral sensorimotor areas were activated in sites that were not the hand. Furthermore, the inferior parietal lobule in the left hemisphere, which synthesizes and integrates multiple sensations showed high activation. Our findings suggested that the mechanism of extra-territorial pain was associated with dysfunction of spatial cognition.

DOI： 10.3233/NRE-193007

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