研究者詳細 - 川部　勤

論文 - 川部　勤

分割表示 124 件中 81 - 100 件目／全件表示 >>

A catheter-type flow sensor for measurement of aspirated- and inspired-air characteristics in the bronchial region. 査読有り

Shikida M, Naito J, Yokota T, Kawabe T, Hayashi Y and K Sato.

J Micromech Microeng 19 巻 ( 10 ) 頁： 1-9 2009年10月

Peptide array-based analysis of the specific IgE and IgG4 in cow's milk allergens and its use in allergy evaluation. 査読有り

Matsumoto N, Okochi M, Matsushima M, Kato R, Takase T, Yoshida Y, Kawase M, Isobe K, Kawabe T, Honda H.

Peptides 30 巻 ( 10 ) 頁： 1840-1847 2009年10月

Erythromycin-induced CXCR4 expression on microvascular endothelial cells. 査読有り

Takagi Y, Hashimoto N, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Hashimoto I, Hayashi Y, Kawabe T, Shimokata K, Hasegawa Y.

Am J Physiol (Lung Cell Mol Physiol) 297 巻 ( 3 ) 頁： L420-431 2009年9月

An influence of Interferon-gamma gene polymorphisms on treatment response to tuberculosis in Japanese population. 査読有り

Shibasaki M, Yagi T, Yatsuya H, Okamoto M, Nishikawa M, Baba H, Hashimoto N, Senda K, Kawabe T, Nakashima K, Imaizumi K, Shimokata K, Hasegawa Y.

Journal of Infection 58 巻 ( 6 ) 頁： 467-469 2009年6月

Up-regulation of surfactant protein production in a mouse model of secondary pulmonary alveolar proteinosis. 査読有り

Shibasaki M, Hashimoto K, Okamoto M, Hayashi Y, Imaizumi K, Hashimoto N, Ozaki N, Yokoi T, Takagi K, Hasegawa Y, Shimokata K, Kawabe T.

Am J Respir Cell Mol Biol 40 巻 ( 5 ) 頁： 536-542 2009年5月

Involvement of heme oxygenase-1 in kaempferol-induced anti-allergic actions in RBL-2H3 cells. 査読有り

Hirose E, Matsushima M, Takagi K, Ota Y, Ishigami K, Hirayama T, Hayashi Y, Nakamura T, Hashimoto N, Imaizumi K, Baba K, Hasegawa Y, Kawabe T.

Inflammation 32 巻 ( 2 ) 頁： 99-108 2009年4月

Inhibition of Degranulation by Myricetin-induced Heme Oxygenase-1 in Mast Cells 査読有り

Ota Y, Matsushima M, Ogawa M, Hirose E, Hirayama T, Yuasa E, Yabuta K, Baba K, Hasegawa Y, Takagi K, Kawabe T.

Occupational and Environmental Allergy 16 巻 ( 2 ) 頁： 61-73 2009年4月

Development of peptide arrays for detection of IgE-binding epitopes in cow's milk allergens. 査読有り

Matsumoto N, Okochi M, Matsushima M, Ogawa A, Takase T, Yoshida Y, Kawase M, Isobe K, Kawabe T, Honda H.

J Biosci Bioeng 107 巻 ( 3 ) 頁： 324-30 2009年3月

Milk Allergen-Specific IgE And IgG4 Antibodies In Patients With Milk Allergy 査読有り

Ito K., Futamura M., Hirayama M., Otsuji K., Kawabe T., Sakamoto T., Tanaka A.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 123 巻 ( 2 ) 頁： S181 - S181 2009年2月

Cytoprotective Effect of Geranylgeranylacetone in Bleomycin-Induced Lung Injury/Fibrosis. 査読有り

Hashimoto N., Fujibayashi T., Nakashima H., Matsuo M., Imaizumi K., Kawabe T., Hasegawa Y.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 179 巻 2009年

Involvement of Transcription Factor Twist into Phenotype Change in Lung Cancer Cells through Epithelial-Mesenchymal Transition. 査読有り

Nakashima H., Hashimoto N., Imaizumi K., Matsuo M., Hashimoto I., Nakamura T., Hayashi Y., Kawabe T., Hasegawa Y.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 179 巻 2009年

Th1/Th2 immune response in lung fibroblasts in interstitial lung disease 査読有り

Sumida Atsushi, Hasegawa Yoshinori, Okamoto Masakazu, Hashimoto Naozumi, Imaizumia Kazuyoshi, Yatsuya Hiroshi, Yokoi Toyoharu, Takagi Kenzo, Shimokata Kaoru, Kawabe Tsutomu

ARCHIVES OF MEDICAL RESEARCH 39 巻 ( 5 ) 頁： 503 - 510 2008年7月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Archives of Medical Research

Background: Inflammatory response in pulmonary fibrosis closely resembles a T-helper (Th) 2 immune response. For recruitment to an inflammatory lesion, the majority of Th1 cells express CXC chemokine receptor 3, recognizing monokine induced by interferon-gamma (Mig), interferon γ-inducible protein of 10 kD (IP-10), and interferon-inducible T-cell α chemoattractant (I-TAC). Th2 cells express CC chemokine receptor 4, recognizing thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC). We investigated the Th1/Th2 chemokine production patterns by lung fibroblasts and their evaluation in bronchoalveolar lavage (BAL) fluid of interstitial lung disease. Methods: The production pattern of Th1/Th2 chemokines by lung fibroblasts was examined in ELISA and quantitative reverse transcriptase polymerase chain reactions. Th1/Th2 chemokine levels in BAL fluid of idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP) were examined to evaluate the clinical relevance of Th1/Th2 chemokines. Results: The lung fibroblasts were polarized to produce Th1-type chemokines by the pro-inflammatory cytokine, tumor necrosis factor (TNF)-α and the anti-fibrotic cytokine, interferon (IFN)-γ. However, the induction patterns of chemokines by these two cytokines were different, i.e., involving predominant induction of IP-10 and I-TAC by TNF-α and induction of Mig by IFN-γ. Although Mig, IP-10, and I-TAC were produced within the BAL fluid of patients, TARC and MDC were at significantly low levels. Conclusions: Our results suggest that lung fibroblasts tend to induce a Th1-type immune response under normal conditions, and that a Th2-type immune response does not play a significant role in smoldering inflammation around the established lesions in IPF and NSIP. © 2008 IMSS.

DOI： 10.1016/j.arcmed.2008.02.005

Web of Science

Scopus

PubMed

Diazotization of kynurenine by acidified nitrite secreted from indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells. 査読有り

Hara T, Yamakura F, Takikawa O, Hiramatsu R, Kawabe T, Isobe KI, Nagase F.

J Immunol Methods 332 巻 ( 1-2 ) 頁： 162-169 2008年3月

High-affinity uptake of kynurenine and nitric oxide-mediated inhibition of indoleamine 2,3-dioxygenase in bone marrow-derived myeloid dendritic cells. 査読有り

Hara T, Ogasawara N, Akimoto H, Takikawa O, Hiramatsu R, Kawabe T, Isobe K, Nagase F.

Immunol Letters 116 巻 ( 1 ) 頁： 95-102 2008年2月

Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. 査読有り

Hiramatsu R, Hara T, Akimoto H, Takikawa O, Kawabe T, Isobe K, Nagase F.

J Cell Biochem 103 巻 ( 1 ) 頁： 42-53 2008年1月

Xenin and xenopsin induce histamine release from rat peritoneal mast cells. 査読有り

Matsushima M, Kitaichi K, Kawabe T, Suzuki R, Baba K, Hasegawa T, Takagi K

14 巻 ( 2 ) 頁： 60-67 2007年9月

Macrophage-derived chemokine in malignant and tuberculous pleurisy 査読有り

Okamoto M, Imaizumi K, Hasegawa Y, Hashimoto N, Sumida A, Shibazaki M, Takagi K, Shimokata K, Kawabe T,

Respirology 12 巻頁： 581–584 2007年7月

Macrophage-derived chemokine in malignant and tuberculous pleural effusions 査読有り

Okamoto Masakazu, Imaizumi Kazuyoshi, Hasegawa Yoshinori, Hashimoto Naozumi, Sumida Atsushi, Shibazaki Masataka, Takagi Kenzo, Shimokata Kaoru, Kawabe Tsutomu

RESPIROLOGY 12 巻 ( 4 ) 頁： 581 - 584 2007年7月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Respirology

Background and objectives: Macrophage-derived chemokine (MDC/CCL22) is recognized as a T-helper (Th) 2-type chemokine. Both malignant and tuberculous pleural effusions are typically lymphocytic pleural effusions. Tuberculous pleural effusions have a more polarized Th1 reaction than malignant effusions, which are predominantly Th2 in nature. The aim of this study was to compare the levels of MDC in malignant pleural effusions with those in tuberculous pleural effusions to help delineate the role of MDC in Th2 versus Th1 effusions. Methods: Forty-three patients with pleural effusions (32 malignant, 11 tuberculous) were studied. The concentration of MDC in the pleural effusion was measured by ELISA. Results: The median concentration of MDC was lower in malignant pleural effusions than in tuberculous pleural effusions (P < 0.005). Conclusions: MDC has been reported to both promote and suppress antitumour immunity. The low concentration of MDC in malignant effusions is likely to minimise its antitumour activity but the precise role of MDC in malignant and tuberculous effusions needs to be investigated further. © 2007 The Authors.

DOI： 10.1111/j.1440-1843.2007.01059.x

Web of Science

Scopus

PubMed

Expression of macrophage-derived chemokine (MDC)/CCL22 in human lung cancer. 査読有り

Nakanishi T, Imaizumi K, Hasegawa Y, Kawabe T, Hashimoto N, Okamoto M, Shimokata K,

Cancer Immunol Immunother 55 巻 ( 11 ) 頁： 1320-1329 2006年11月

Successful re-treatment with gefitinib for carcinomatous meningitis as disease recurrence of non-small-cell lung cancer 査読有り

Hashimoto N, Imaizumi K, Honda T, Kawabe T, Nagasaka T, Shimokata K, T, Hasegawa Y,

Lung cancer 53 巻 ( 3 ) 頁： 387-390 2006年9月

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