研究者詳細 - 川部　勤

論文 - 川部　勤

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Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis 査読有り国際共著

Nakahara Y, Hashimoto N, Sakamoto K, Enomoto A, Adams TS, Yokoi T, Omote N, Poli S, Ando A, Wakahara K, Suzuki A, Inoue M, Hara A, Mizutani Y, Imaizumi K, Kawabe T, Rosas IO, Takahashi M, Kaminski N, Hasegawa Y

European Respiratory Journal 58 巻 ( 6 ) 頁： 2003397 2021年

Development of sensor-probe system with function of measuring flow and pressure for evaluating breathing property at airway in lungs 査読有り

KAWAMOTO Yuji, MAEDA Yoshihumi, HASEGAWA Yoshihiro, MATSUSHIMA Miyoko, KAWABE Tsutomu, SHIKIDA Mitsuhiro

Microsystem Technologies 2021年

Catheter sensor system for in-situ breathing and optical imaging measurements at airway in inside of lung 査読有り

MAEDA Yoshihumi, HASEGAWA Yoshihiro, TANIGUCHI Kazuhiro, MATSUSHIMA Miyoko, SUGIYAMA Tomoshi, KAWABE Tsutomu, SHIKIDA Mitsuhiro

Microsystem Technologies 26 巻 ( 12 ) 頁： 3705 - 3713 2020年12月

Involvement of heme oxygenase-1 in suppression of T cell activation by quercetin 査読有り

Sugiyama Tomoshi, Matsushima Miyoko, Ohdachi Tomoko, Hashimoto Naozumi, Hasegawa Yoshinori, Yokoi Kohei, Kawabe Tsutomu

Immunopharmacology and immunotoxicology 42 巻 ( 4 ) 頁： 295 - 305 2020年8月

Micro-machined respiratory monitoring system development for artificial ventilator in animal experiment 査読有り

Yoshida Homare, Hasegawa Yoshihiro, Matsushima Miyoko, Sugiyama Tomoshi, Kawabe Tsutomu, Shikida Mitsuhiro

Microsystem Technologies 26 巻 ( 12 ) 頁： 3715 - 3724 2020年4月

Development of micromachined flow sensor for drip infusion system 査読有り

Shimohira Chihiro, Hasegawa Yoshihiro, Taniguchi Kazuhiro, Matsushima Miyoko, Kawabe Tsutomu, Shikida Mitsuhiro

Microsystem Technologies 26 巻 ( 12 ) 頁： 3677 - 3683 2020年4月

UHRF1, a Regulator of Methylation, as a Diagnostic and Prognostic Marker for Lung Cancer 査読有り

Goto Daiki, Komeda Kazuki, Uwatoko Natsuki, Nakashima Moeka, Koike Mayu, Kawai Kaho, Kodama Yuta, Miyazawa Ayako, Tanaka Ichidai, Hase Tetsunari, Morise Masahiro, Hasegawa Yoshinori, Kawabe Tsutomu, Sato Mitsuo

Cancer investigation 38 巻 ( 4 ) 頁： 240 - 249 2020年4月

Energy-less respiration monitoring device using thermo-sensitive film 査読有り

Maeda Yoshihumi, Hasegawa Yoshihiro, Taniguchi Kazuhiro, Matsushima Miyoko, Kawabe Tsutomu, Shikida Mitsuhiro

Microsystem Technologies 26 巻 ( 2 ) 頁： 489 - 497 2020年2月

Body temperature measurement based on breathing airflow for continuous monitoring of patient body condition during large scale disasters

Fujinori Tomohiro, Hasegawa Yoshihiro, Matsushima Miyoko, Kawabe Tsutomu, Shikida Mitsuhiro

25 巻 ( 11 ) 頁： 4313 - 4321 2019年11月

Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research. 査読有り

Ohno T, Miyasaka Y, Kuga M, Ushida K, Matsushima M, Kawabe T, Kikkawa Y, Mizuno M, Takahashi M

Experimental animals 68 巻 ( 3 ) 頁： 243-255 2019年8月

A micro-machined flow sensor formed on copper on a polyimide substrate and its application to respiration measurement 査読有り

Kato Ayami, Hasegawa Yoshihiro, Taniguchi Kazuhiro, Matsushima Miyoko, Kawabe Tsutomu, Shikida Mitsuhiro

JAPANESE JOURNAL OF APPLIED PHYSICS 58 巻 ( SD ) 2019年6月

Repressive role of stabilized hypoxia inducible factor 1 α expression on transforming growth factor beta-induced extracellular matrix production in lung cancer cells 査読有り

Ando Akira, Hashimoto Naozumi, Sakamoto Koji, Omote Norihito, Miyazaki Shinichi, Nakahara Yoshio, Imaizumi Kazuyoshi, Kawabe Tsutomu, Hasegawa Yoshinori

CANCER SCIENCE 110 巻 ( 6 ) 頁： 1959-1973 2019年6月

Wavelength Dependence of Ultrahigh-Resolution Optical Coherence Tomography Using Supercontinuum for Biomedical Imaging 招待有り査読有り

Nishizawa Norihiko, Kawagoe Hiroyuki, Yamanaka Masahito, Matsushima Miyoko, Mori Kensaku, Kawabe Tsutomu

IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS 25 巻 ( 1 ) 2019年

呼気への不揮発性化合物の排泄機構とその非侵襲的薬物モニタリングへの応用招待有り査読有り

山本　敦、山本良平、川部　勤

ぶんせき 2018 巻 ( 12 ) 頁： 534 - 539 2018年12月

Analysis of measurement conditions for detecting change in vital signs with catheter flow sensor 査読有り

Hasegawa Y., Mitsunari Y., Kawaoka H., Matsushima M., Kawabe T., Shikida M.

JOURNAL OF MICROMECHANICS AND MICROENGINEERING 28 巻 ( 10 ) 2018年10月

Catheter type thermal flow sensor with small footprint for measuring breathing function 査読有り

Y. Hasegawa, H. Kawaoka, Y. Mitsunari, M. Matsushima, T. Kawabe, M. Shikida

Microsystem Technologies 24 巻 ( 8 ) 頁： 3455 - 3465 2018年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Verlag

We preivously developed a catheter type flow sensor for measuring breathing and heartbeat information from breathing at the mouth [Hasegawa et al. J Micromech Microeng 27(12): 125016, (2017)
Kawaoka et al. Tech. Dig. IEEE Micro Electro Mechanical Systems Conference 2016, pp 359–362]. In this study, we redesigned and developed the new sensor configuraiton for the catheter flow sensor to downsize and improve the sensor characteristics. The previous flow sensor consists of two pairs of a heater and a temperature compensation sensor for flow rate detection. The two heaters also functioned not only for flow rate detection but also for flow direction detection. The two temperature compensation sensors had a large footprint and corresponded to each heater. Therefore, the sensor occupied a large area, and it was necessary to match the heater characteristics for flow rate detection. The newly designed sensor is composed of a set of a heater and a temperature compensation sensor and two flow direction sensors. By providing the new flow direction sensors, the number of temperature compensation sensors with a large footprint was reduced to one. Thus, the area of the new sensor design was 15.0 mm2, which was reduced to 54.5% of the 27.0 mm2 of the previous sensor area by providing the flow direction sensors. Then, the new catheter type flow sensor was fabricated, and the flow characteristics for measuring breathing funciton were evaluated. Finally, we applied the catheter type flow sensor to an animal experiment using a rat, and it could evaluate the flow rate characteristics of the rat’s breathing as a reciprocating flow including flow direction. Moreover, the obtained breathing characteristics were within the range of the physiological values of rats.

DOI： 10.1007/s00542-018-3748-y

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Development of tube flow sensor by using film transfer technology and its application to in situ breathing and surface image evaluation in airways

24 巻 ( 8 ) 頁： 3417 - 3424 2018年8月

Obstetric factors associated with salivary cortisol levels of healthy full-term infants immediately after birth

Takahashi Y., Matsushima M., Nishida T., Tanabe K., Kawabe T., Tamakoshi K.

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY 45 巻 ( 6 ) 頁： 828-832 2018年

Characterization of basket-forceps-type micro-flow-sensor for breathing measurements in small airway 査読有り

Naoaki Harada, Yoshihiro Hasegawa, Ryota Ono, Miyoko Matsushima, Tsutomu Kawabe, Mitsuhiro Shikida

Microsystem Technologies 23 巻 ( 12 ) 頁： 5397 - 5406 2017年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

We previously proposed a basket-forceps-type flow sensor, in which a flexible thermal flow sensor is mounted onto basket forceps to fix the flow sensor onto the inside surface of the airway. The basket-forceps-type flow sensor has an asymmetrical structure to prevent reciprocating airflow; thus, we investigated the characteristics of the basket-forceps-type flow sensor under both expired- and inspired-airflow conditions in this study. The thermal flow sensor was fabricated on a flexible polyimide film and mounted onto a guide tube of a basket-forceps. Two heaters and their electrical wiring patterns were designed to produce symmetric heat distribution over the heaters. The effects of the basket structure and guide tube on flow-rate measurement were experimentally evaluated, and it was confirmed that they did not affect sensor output. Conversely, sensor output decreased with the increase in tube diameter due to the reduction in the average flow velocity with the diameter increase. Thus, we carried out a procedure to construct a calibration curve under an arbitrary tube diameter. Finally, we applied the basket-forceps-type flow sensor in an animal experiment in which it successfully detected the breathing properties in the airway of a rat.

DOI： 10.1007/s00542-016-3265-9

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Heartbeat Signal Detection From Analysis of Airflow in Rat Airway Under Different Depths of Anaesthesia Conditions 査読有り

Hidetaka Kawaoka, Takayuki Yamada, Miyoko Matsushima, Tsutomu Kawabe, Yoshihiro Hasegawa, Mitsuhiro Shikida

IEEE SENSORS JOURNAL 17 巻 ( 14 ) 頁： 4369 - 4377 2017年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC

We inserted a tubular flow sensor incorporating micro-electro-mechanical systems technologies directly into the rat airway and analyzed the airflow waveforms obtained under different depths of anaesthesia conditions by using discrete Fourier transformation (DFT) to evaluate the heartbeat frequency. The electrocardiogram (ECG) signal was used as the reference heartbeat frequency. The calibration curve of the flow sensor used to measure the oscillating airflow in the rat airway was determined on the basis of King's law. The airflow waveform at the rat airway caused by only the heartbeat was measured by applying deep anaesthesia; the waveform frequency coincided with the simultaneously measured ECG signal frequency. DFT analysis of the airflow signals measured under deep and shallow anaesthesia conditions verified the fundamental heartbeat frequency values. The airflow components related to heartbeat motion were successfully extracted by using the heartbeat frequency spectrum. The respiration and heartbeat signals were thus successfully detected.

DOI： 10.1109/JSEN.2017.2707594

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論文 - 川部 勤

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論文 - 川部　勤