研究者詳細 - 川部　勤

論文 - 川部　勤

分割表示 124 件中 61 - 80 件目／全件表示 >>

Micromachined catheter flow sensor and its applications in breathing measurements in animal experiments. 査読有り

Shikida M, Shikano T, Matsuyama T, Yamazaki Y, Matsushima M, Kawabe T.

Microsyst Technol. 20 巻 ( 3 ) 頁： 505-513 2013年1月

Respiratory Volume Estimation by a Stretchable Textile Sensor 査読有り

Enokibori Yu, Ito Yoshu, Ikeda Koji, Suzuki Akihisa, Shimakami Yuuki, Kawabe Tsutomu, Mase Kenji

SMART AND INTERACTIVE TEXTILES 80 巻頁： 136 - + 2013年

THE RELATIONSHIP BETWEEN MUSCLE WEAKNESS AND POSTOPERATIVE CATABOLISM AFTER CORONARY ARTERY BYPASS GRAFT SURGERY 査読有り

Iida Y., Iwatsu K., Kawabe T., Tsubouchi H., Usui A., Yamada S.

INTENSIVE CARE MEDICINE 38 巻頁： S90 - S91 2012年10月

Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury 査読有り

Sakamoto K, Hashimoto N, Kondoh Y, Imaizumi K, Aoyama D, Kohnoh T, Kusunose M, Kimura M, Kawabe T, Taniguchi H, Hasegawa Y

Am J Physiol Lung Cell Mol Physiol 303 巻 ( 1 ) 頁： L43-53 2012年7月

Involvement of the transcription factor twist in phenotype alteration through epithelial-mesenchymal transition in lung cancer cells 査読有り

Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y.

Mol Carcinog. 51 巻 ( 5 ) 頁： 400-410 2012年7月

Inspiratory capacity as a preoperative assessment of patients undergoing thoracic surgery 査読有り

Matsuo M, Hashimoto N, Usami N, Imaizumi K, Wakai K, Kawabe T, Yokoi K, Hasegawa Y.

Interact Cardiovasc Thorac Surg. 14 巻 ( 5 ) 頁： 560-564 2012年5月

Observation of Fine Lung Structure by Ultrahigh-Resolution Optical Coherence Tomography Using 800, 1060, and 1300nm Supercontinua 査読有り

Ishida S, Nishizawa N, Kitatsuji M, Ohshima H, Hasegawa Y, Matsushima M, Kawabe T.

Jpn. J. Appl. Phys 51 巻頁： 047001 2012年3月

Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells 査読有り

Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, Hashimoto N, Imaizumi K, Shimokata K, Hasegawa Y, Kawabe T.

Biochem Biophys Res Commun 417 巻 ( 1 ) 頁： 169-174 2012年1月

The usefulness of casein-specific IgE and IgG4 antibodies in cow's milk allergic children. 査読有り

Ito K, Futamura M, Moverare R, Tanaka A, Kawabe T, Sakamoto T, Borres MP

Clin Mol Allergy 10 巻 ( 1 ) 頁： 1-7 2012年1月

ミルクタンパク質全網羅ペプチドアレイを用いたIgG結合ペプチドの探索査読有り

片山　真、杉田智哉、加藤竜司、大河内美奈、松島充代子、川部　勤、高瀬智和、吉田安子、川瀬三雄、本多裕之

化学工学論文集 37 巻 ( 6 ) 頁： 546-550 2011年9月

CD40/CD40 ligand interactions in immune responses and pulmonary immunity 査読有り

Kawabe T, Matsushima M, Hashimoto N, Imaizumi K, Hasegawa Y.

Nagoya J Med Sci 73 巻 ( 3-4 ) 頁： 69-78 2011年8月

Attenuation of Transforming Growth Factor-β-Stimulated Collagen Production in Fibroblasts by Quercetin-Induced Heme Oxygenase-1 査読有り

Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T.

Am J Respir Cell Mol Biol 44 巻 ( 5 ) 頁： 614-620 2011年5月

Comparison of salivary cortisol, heart rate, and oxygen saturation between early skin-to-skin contact with different initiation and duration times in healthy, full-term infants 査読有り

Yuki Takahashi, Koji Tamakoshi, Miyoko Matsushima, Tsutomu Kawabe

EARLY HUMAN DEVELOPMENT 87 巻 ( 3 ) 頁： 151 - 157 2011年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER IRELAND LTD

Background: There are few studies that compare the physiological and biological efficacies between different early skin-to-skin contacts (SSC) post birth.
Aim: To investigate physiologically and biochemically how early SSC with different initiation and duration time influence the stress post birth for full-term infants.
Study design: Non-experimental study.
Subjects: Study I; Thirty-two infants who began SSC 5 min or less [birth SSC, mean initiation time (standard deviation): 1.6 (1.1) min] after birth and 36 infants who did so more than 5 min [very early SSC, 26.3 (5.0) min] in heart rate (HR) and oxygen saturation (SpO(2)) analysis. Study II; Eighteen infants who underwent SSC for 60 min or less [mean initiation time: 7.5 (12.2) min] and 61 infants who did so for more than 60 min [15.3 (12.5) min] in salivary cortisol analysis.
Outcome measures: HR and SpO(2) measured for 30 min post birth. Salivary cortisol concentration measured at 1 min, 60 min, and 120 min post birth.
Results: Birth SSC group reached HR stability of 120-160 bpm significantly faster than very early SSC group by Kaplan-Meier analysis (P=0.001 by log-rank test). As for SpO(2) stability of 92% and 96%, no significantly between-group difference was found. Salivary cortisol levels were significantly lower between 60 and 120 min after birth in SSC group, continuing for more than 60 min compared with SSC group for 60 min or less after adjustment for salivary cortisol level at 1 min besides the infant stress factors (P=0.046).
Conclusions: Earlier SSC beginning within 5 min post birth and longer SSC continuing for more than 60 min within 120 min post birth are beneficial for stability of cardiopulmonary dynamics and the reduction of infant stress during the early period post birth. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.earlhumdev.2010.11.012

Ex-vivo ultra-high-resolution optical coherence tomography imaging of fine lung structure by use of a high-power Gaussian-like supercontinuum at 0.8-um wavelength. 査読有り

Nishizawa N., Ishida S., Ohta T., Itoh K., Kitatsuji M., Ohshima H., Hasegawa Y., Matsushima M., Kawabe T.

ENDOSCOPIC MICROSCOPY VI 7893 巻 2011年

The Role Of Interleukin-17/Th17 In Human Interstitial Pneumonia 査読有り

Ogawa T., Imaizumi K., Hashimoto N., Hashimoto I., Imai N., Tomita Y., Kounou T., Sakamoto K., Aoyama D., Kusunose M., Ito S., Sato M., Kondo M., Kawabe T., Hasegawa Y.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 183 巻 2011年

Characteristics of an optimized catheter-type thermal flow sensor for measuring reciprocating airflows in bronchial pathways 査読有り

M. Shikida, T. Yokota, T. Kawabe, T. Funaki, M. Matsushima, S. Iwai, N. Matsunaga, K. Sato

JOURNAL OF MICROMECHANICS AND MICROENGINEERING 20 巻 ( 12 ) 頁： 1-11 2010年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：IOP PUBLISHING LTD

We optimized a catheter-type thermal flow sensor to measure the reciprocating airflows in bronchial pathways. The electrical wiring in the outer tube was extracted to keep the symmetry of the temperature distribution on the heaters. First, a flexible sensor was fabricated on polyimide film with photolithography, and then the enameled wires were bonded to the contact pads on the film with anisotropic conductive film. The film sensor was finally assembled with a catheter configuration that had a diameter of 1.8 mm by applying a heat shrinkable tube. We experimentally confirmed that the sensor outputs under both forward and reverse flow conditions had the same output characteristics when a design with symmetrical heating elements was applied. The sensor outputs we obtained at a reciprocating flow frequency ranging from 1 to 3 Hz almost coincided, and they also fit that obtained under unidirectional airflow conditions. Finally, the aspirated-and inspired-air characteristics in the air passages of small laboratory animals (rats and mice) were measured. Due to our development of a flexible method of electrical wiring, we could try a new approach to intubation measurements in which the sensor was inserted into the air passage from the mouth with a fiberscope, and we confirmed that the sensor we developed was able to directly measure the breathing characteristics in air passages. Implanted measurements were also attempted in this study.

DOI： 10.1088/0960-1317/20/12/125030

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Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues. 査読有り

Hirayama T, Kawabe T, Matsushima M, Nishimura Y, Kobe Y, Ota Y, Baba K, Takagi K.

Peptides 31 巻 ( 11 ) 頁： 2109-13 2010年11月

Endothelial-Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis 査読有り

Naozumi Hashimoto, Sem H. Phan, Kazuyoshi Imaizumi, Masaki Matsuo, Harunori Nakashima, Tsutomu Kawabe, Kaoru Shimokata, Yoshinori Hasegawa

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 43 巻 ( 2 ) 頁： 161 - 172 2010年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER THORACIC SOC

The pathological hallmark lesions in idiopathic pulmonary fibrosis are the fibroblastic foci, in which fibroblasts are thought to be involved in the tissue remodeling, matrix deposition, and cross-talk with alveolar epithelium. Recent evidence indicates that some fibroblasts in fibrosis may be derived from bone marrow progenitors as well as from epithelial cells through epithelial-mesenchymal transition. To evaluate whether endothelial cells could represent an additional source for fibroblasts, bleomycin-induced lung fibrosis was established in Tie2-Cre/CAG-CAT-LacZ double-transgenic mice, in which LacZ was stably expressed in pan-endothelial cells. Combined X-gal staining and immunocytochemical staining for type I collagen and alpha-smooth muscle actin revealed the presence of X-gal-positive cells in lung fibroblast cultures from bleomycin-treated mice. To explore the underlying mechanisms, by which loss of endothelial-specific markers and gain of mesenchymal phenotypes could be involved in microvascular endothelial cells, the effects of activated Ras and TGF-beta on the microvascular endothelial cell line MS1 were analyzed. Combined treatment with activated Ras and TGF-beta caused a significant loss of endothelial-specific markers, while inducing de nova mesenchymal phenotypes. The altered expression of these markers in MS1 cells with activated Ras persisted after withdrawal of TGF-beta in vitro and in vivo. These findings are the first to show that lung capillary endothelial cells could give rise to significant numbers of fibroblasts through an endothelial-mesenchymal transition in bleomycin-induced lung fibrosis model.

DOI： 10.1165/rcmb.2009-0031OC

Differential Th1/Th2 chemokine expression in interstitial pneumonia. 査読有り

Honda T, Imaizumi K, Yokoi T, Hashimoto N, Hashimoto I, Kawabe T, Matsuo M, Iwano S, Shimokata K, Hasegawa Y.

Am J Med Sci 339 巻 ( 1 ) 頁： 41-8 2010年1月

Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. 査読有り

Matsushima M, Takagi K, Ogawa M, Hirose E, Ota Y, Abe F, Baba K, Hasegawa T, Hasegawa Y, Kawabe T.

Inflammation Research 58 巻 ( 10 ) 頁： 705-715 2009年10月

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