研究者詳細 - 大平　英樹

論文 - 大平　英樹

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Vagal nerve activity as a moderator of brain-immune relationships

Ohira Hideki, Matsunaga Masahiro, Osumi Takahiro, Fukuyama Seisuke, Shinoda Jun, Yamada Jitsuhiro, Gidron Yori

JOURNAL OF NEUROIMMUNOLOGY 260 巻 ( 1-2 ) 頁： 28 - 36 2013年7月

Vagal nerve activity as a moderator of brain-immune relationships. 査読有り

Ohira,H., Matsunaga,M., Osumi,T., Fukuyama,S., Shinoda,J., Yamada,J., &Gidron,Y.

Journal of Neuroimmunology ( 260 ) 頁： 28-36 2013年7月

Vagal nerve activity as a moderator of brain-immune relationships 査読有り

Hideki Ohira, Masahiro Matsunaga, Takahiro Osumi, Seisuke Fukuyama, Jun Shinoda, Jitsuhiro Yamada, Yori Gidron

JOURNAL OF NEUROIMMUNOLOGY 260 巻 ( 1-2 ) 頁： 28 - 36 2013年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE BV

We investigated whether vagal tone, as assessed by heart rate variability (HRV), moderates the neural correlates of immune and physiological responses to acute stress. Participants with low and high baseline HRV underwent a reversal learning task as an acute stressor. Natural killer cells, norepinephrine, and adrenocorticotropic hormone in peripheral blood changed with acute stress in the high HRV group only. Activity in the prefrontal cortex and striatum correlated with the immune and physiological indices in the high HRV group. High vagal tone may reflect more flexible top-down brain regulation of immune and physiological activity. (C) 2013 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jneuroim.2013.04.011

Web of Science

Prognosis of autoimmune hepatitis showing acute presentation

Yamamoto K., Miyake Y., Ohira H., Suzuki Y., Zeniya M., Onji M., Tsubouchi H., Yoshizawa K., Morizane T., Hibi T., Aoyagi Y., Nakanuma Y., Hirohara J., Takikawa H., Ishibashi H., Shimoda S., Sakisaka S., Nakamuta M., Matsuzaki Y., Saibara T., Ueno Y., Miyakawa H., Kokudo N., Egawa H., Maehara Y., Mochida S., Sakaida I., Fujisawa T., Suzuki K., Inoue K., Ichida T., Yokosuka O., Fukui H., Moriwaki H., Mori M., Mori T., Nagino M., Sata N., Tazuma S., Yasaka T., Tsuyuguchi T., Shoda J., Honda M., Yamaue H., Unno M., Hayashi N.

Hepatology Research 43 巻 ( 6 ) 頁： 630 - 638 2013年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Hepatology Research

Aim: The number of patients with autoimmune hepatitis (AIH) showing acute presentation has increased. This study aimed to assess their prognosis. Methods: A survey of AIH patients by sending questionnaires was performed, and 96 patients showing acute presentation were investigated. Results: The median age was 58 years and 78 patients (81%) were female. Eighty-four patients (88%) were positive for antinuclear antibody and/or anti-smooth muscle antibody. The median serum immunoglobulin G level was 2252mg/dL. Twenty-five patients (26%) showed histological acute hepatitis. As initial treatment, 88 patients (92%) were treated with corticosteroid, and 28 of them received pulse steroid treatment. Overall, 11 patients (11%) reached fatal outcomes (nine death and two liver transplantation). Patients with histological acute hepatitis showed higher serum bilirubin levels, lower prothrombin activities and higher prothrombin time-international normalized ratios (PT-INR) and reached fatal outcomes more frequently. With a multivariate logistic regression analysis, prothrombin activity and PT-INR at presentation was associated with fatal outcomes. Nine of 13 patients (69%) showing prothrombin activity of 40% or lower at presentation and nine of 19 patients (47%) showing PT-INR of 1.5 or higher reached fatal outcomes. Furthermore, of 13 patients showing prothrombin activity of 40% or lower and/or PT-INR of 1.5 or higher at presentation who were treated with pulse steroid treatment, four (31%) died from infectious disease. Conclusion: Prothrombin activity and PT-INR are prognostic factors for AIH showing acute presentation. Physicians should pay attention to the development of infectious disease when pulse steroid treatment is performed. © 2012 The Japan Society of Hepatology.

DOI： 10.1111/j.1872-034X.2012.01109.x

Scopus

Eye-Blink Behaviors in 71 Species of Primates

Tada Hideoki, Omori Yasuko, Hirokawa Kumi, Ohira Hideki, Tomonaga Masaki

PLOS ONE 8 巻 ( 5 ) 2013年5月

Eye-Blink Behaviors in 71 Species of Primates

Tada H., Omori Y., Hirokawa K., Ohira H., Tomonaga M.

PLoS ONE 8 巻 ( 5 ) 2013年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PLoS ONE

The present study was performed to investigate the associations between eye-blink behaviors and various other factors in primates. We video-recorded 141 individuals across 71 primate species and analyzed the blink rate, blink duration, and "isolated" blink ratio (i.e., blinks without eye or head movement) in relation to activity rhythms, habitat types, group size, and body size factors. The results showed close relationships between three types of eye-blink measures and body size factors. All of these measures increased as a function of body weight. In addition, diurnal primates showed more blinks than nocturnal species even after controlling for body size factors. The most important findings were the relationships between eye-blink behaviors and social factors, e.g., group size. Among diurnal primates, only the blink rate was significantly correlated even after controlling for body size factors. The blink rate increased as the group size increased. Enlargement of the neocortex is strongly correlated with group size in primate species and considered strong evidence for the social brain hypothesis. Our results suggest that spontaneous eye-blinks have acquired a role in social communication, similar to grooming, to adapt to complex social living during primate evolution. © 2013 Tada et al.

DOI： 10.1371/journal.pone.0066018

Scopus

Vagal nerve activity as a moderator of brain-immune relationships

Ohira H., Matsunaga M., Osumi T., Fukuyama S., Shinoda J., Yamada J., Gidron Y.

Journal of Neuroimmunology 260 巻 ( 1-2 ) 頁： 28 - 36 2013年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Neuroimmunology

DOI： 10.1016/j.jneuroim.2013.04.011

Scopus

Eye-Blink Behaviors in 71 Species of Primates 査読有り

Hideoki Tada, Yasuko Omori, Kumi Hirokawa, Hideki Ohira, Masaki Tomonaga

PLOS ONE 8 巻 ( 5 ) 頁： e66018 2013年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PUBLIC LIBRARY SCIENCE

The present study was performed to investigate the associations between eye-blink behaviors and various other factors in primates. We video-recorded 141 individuals across 71 primate species and analyzed the blink rate, blink duration, and "isolated'' blink ratio (i.e., blinks without eye or head movement) in relation to activity rhythms, habitat types, group size, and body size factors. The results showed close relationships between three types of eye-blink measures and body size factors. All of these measures increased as a function of body weight. In addition, diurnal primates showed more blinks than nocturnal species even after controlling for body size factors. The most important findings were the relationships between eye-blink behaviors and social factors, e.g., group size. Among diurnal primates, only the blink rate was significantly correlated even after controlling for body size factors. The blink rate increased as the group size increased. Enlargement of the neocortex is strongly correlated with group size in primate species and considered strong evidence for the social brain hypothesis. Our results suggest that spontaneous eye-blinks have acquired a role in social communication, similar to grooming, to adapt to complex social living during primate evolution.

DOI： 10.1371/journal.pone.0066018

Web of Science

Pro-inflammatory cytokine predicts reduced rejection of unfair financial offers

Ohira H., Osumi T., Matsunaga M., Yamakawa K.

Neuroendocrinology Letters 34 巻 ( 1 ) 頁： 47 - 51 2013年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Neuroendocrinology Letters

OBJECTIVES: This study aimed to examine one of biological correlates, proinflammatory cytokine, in rejection of unfair financial offers in the Ultimatum Game (UG), where the division of a sum of money is proposed and the player can accept or reject this offer. METHODS: Nineteen participants played 20 trials of the UG as responders, and they were proposed unfair offers in a half of the trials. Baseline levels of several pro-inflammatory and anti-inflammatory cytokines, subjective happiness, and depression of them were measured. RESULTS: Participants with higher levels of the pro-inflammatory cytokine, interleukin (IL)-6 rejected fewer unfair offers. This effect of IL-6 levels on decision-making was independent from other pro-inflammatory cytokines, anti-inflammatory cytokines, subjective happiness, and depression. CONCLUSIONS: These results suggested that chronic higher levels of IL-6 might affect functions of neural regions related to decision making, and thus can modulate rejection of unfair offers. © 2013 Neuroendocrinology Letters.

Scopus

VAGAL TONE MODULATES FUNCTIONAL BRAIN-BODY ASSOCIATION

Ohira Hideki, Matsunaga Masahiro, Osumi Takahiro, Gidron Yori

PSYCHOSOMATIC MEDICINE 75 巻 ( 3 ) 頁： A108 - A108 2013年4月

PAVLOVIAN-INSTRUMENTAL TRANSFER BY ACUTE STRESS IN DECISION MAKING

Yamakawa Kaori, Matsunaga Masahiro, Isowa Tokiko, Ohira Hideki

PSYCHOSOMATIC MEDICINE 75 巻 ( 3 ) 頁： A112 - A112 2013年4月

慢性ストレスと意思決定査読有り

大平英樹

ストレス科学研究 28 巻頁： 8-15 2013年

Pro-inflammatory cytokine predicts reduced rejection of unfair financial offers. 査読有り

Ohira,H., Osumi,T., Matsunaga,M., & Yamakawa,K.

Neuroendocrinology Letters ( 34 ) 頁： 47-51 2013年

Brain-Immune Interaction Accompanying Odor-evoked Autobiographic Memory. 査読有り

Matsunaga, M., Bai, Y., Yamakawa, K., Toyama, A., Kashiwagi, M., Fukuda, K., Oshida, A., Sanada, K., Fukuyama, S., Shinoda, J., Yamada, J., Sadato, N., & Ohira, H.

PLoS ONE 8 巻 ( 8 ) 頁： e72523 2013年

Eye-Blink Behaviors in 71 Species of Primates. 査読有り

Tada, H., Omori, Y., Hirokawa, K., Ohira, H., & Tomonaga, M.

PLoS ONE 8 巻頁： e66018 2013年

Modulation of Emotion by Cognitive Activity. 査読有り

Iida, S., Tanabe, C, H., Nakao, T., & Ohira, H.

Psychological Topics 22 巻 ( 2 ) 頁： 205-219 2013年

音楽のストレス解消効果について

中嶋麻菜, 海老原直邦, 西条寿夫, 大平英樹

人間環境学研究 11 巻 ( 1 ) 頁： 19 - 25 2013年

身体の覚醒の低下はサイコパシーとリスク選択を結びつけるか:―媒介分析による検討―

大隅尚広, 梅田聡, 大平英樹

感情心理学研究 21 巻 ( Supplement ) 頁： 34 - 34 2013年

慢性ストレスと意思決定

大平英樹

ストレス科学研究 28 巻 ( 0 ) 頁： 8 - 15 2013年

慢性ストレスと意思決定査読有り

大平英樹

ストレス科学研究 28 巻頁： 8-15 2013年

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