Updated on 2025/10/29

写真a

 
ARIMA Akihide
 
Organization
Institutes of Innovation for Future Society Institute of Quantum Chemistry Innovation Designated Lecturer
Title
Designated Lecturer

Degree 1

  1. 博士(理学) （ 2016.3   大阪大学 ） 

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Research Interests 3

  1. ナノポア

  2. Micro-Nanodevice

  3. Nanobiodevice

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Research Areas 3

  1. Nanotechnology/Materials / Nanobioscience

  2. Nanotechnology/Materials / Nano/micro-systems

  3. Nanotechnology/Materials / Analytical chemistry

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Current Research Project and SDGs 2

  1. ナノバイオデバイスを用いた単一生体粒子分析

  2. 機能性ナノポアの開発

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Research History 5

  1. Nagoya University   Institute of Quantum and Chemical Innovation, Institutes of Innovation for Future Society   Designated Lecturer

    2024.4

  2. Nagoya University   Institute of Nano-Life-Systems, Institutes of Innovation for Future Society   Designated Lecturer

    2021.4 - 2024.3

  3. Nagoya University   Graduate School of Engineering, Biomolecular Engineering   Designated Assistant Professor

    2019.4 - 2021.3

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    Country：Japan

  4. Osaka University   The Institute of Scientific and Industrial Research Nanoscience and Nanotechnology Center   Specially Appointed Assistant Professor

    2016.4 - 2019.3

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    Country：Japan

  5. 日本学術振興会特別研究員(DC2)

    2015.4 - 2016.3

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    Country：Japan

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Education 3

  1. Osaka University   Graduate School, Division of Natural Science

    2013.4 - 2016.3

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    Country： Japan

  2. Osaka University   Graduate School, Division of Natural Science

    2011.4 - 2013.3

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    Country： Japan

  3. Osaka University   Faculty of Science

    2007.4 - 2011.3

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    Country： Japan

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Professional Memberships 4

  1. THE SOCIETY FOR CHEMISTRY AND MICRO-NANO SYSTEMS

  2. THE JAPAN SOCIETY OF APPLIED PHYSICS

  3. THE CHEMICAL SOCIETY OF JAPAN

  4. 日本分析化学会

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Committee Memberships 3

  1. 第86回応用物理学会秋季学術講演会   シンポジウム世話人  

    2025   

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    Committee type：Academic society

  2. 応用物理学会 有機分子・バイオエレクトロニクス分科会   幹事  

    2020 - 2021   

  3. 日本分析化学会第69年会   実行委員  

    2020   

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Awards 8

  1. Encouragement Award

    2022.9   The Japan Society for Analytical Chemistry   Development of Single-Bioparticle Analysis Using Nano/Micropore Devices

    Akihide Arima

  2. Early Career Award on the Chemical Society of Japan, Tokai Branch

    2021.10   The Chemical Society of Japan, Tokai Branch   Development of Single-Particle Analysis Based on Ionic Current Measurement Using Nanobiodevices

  3. 令和元年度 若手優秀賞

    2020.3   一般社団法人 化学とマイクロ・ナノシステム学会   ナノポアデバイスによる単一生体粒子分析

    有馬 彰秀

  4. 令和元年度愛知県若手研究者イノベーション創出奨励事業 第14回わかしゃち奨励賞 優秀賞

    2019.1   愛知県・（公財）科学技術交流財団・（公財）日比科学技術振興財団   ナノバイオデバイスを用いた革新的１細胞診断法の創成

    有馬 彰秀

  5. ImPACT宮田プログラム公開成果報告会 優秀賞

    2018.12   国立研究開発法人 科学技術振興機構 革新的研究開発推進プログラム(ImPACT)   ナノポアセンサの社会実装に向けた取り組み

    有馬彰秀

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  6. 化学とマイクロ・ナノシステム学会 第36回研究会 優秀研究賞

    2017.10   一般社団法人 化学とマイクロ・ナノシステム学会   糖鎖修飾ナノポアによるウイルス検出と感染能評価

    有馬彰秀, 堀口諭吉, 筒井真楠, 殿村渉, 横田一道, 谷口正輝, 宮原裕二, 川合知二

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  7. 第5回ナノスケール分子デバイス若手セミナー 奨励賞

    2016.3   日本化学会 新研究領域グループ ナノスケール分子デバイス   ナノポアトラップ法を用いた単一微粒子分析

    有馬　彰秀

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  8. 第五回夏期セミナー 若手優秀賞

    2011.8   日本分析化学会近畿支部  

    有馬　彰秀

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

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To the head of Awards.▲
 

Papers 35

  1. Recent advances in single-particle analysis with nanopore technology Invited Reviewed

    Akihide Arima

    Analytical Sciences   Vol. 41   page： 677 - 685   2025.4

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    Authorship：Lead author,　Corresponding author  

    DOI： 10.1007/s44211-025-00757-1

  2. Enhanced Discriminability of Viral Vectors in Viscous Nanopores Reviewed Open Access

    Makusu Tsutsui, Yuji Tsunekawa, Mikako Wada, Akihide Arima, Azusa Onodera, Masumi Nishina, Miho Nagoya, Yoshinobu Baba, Tomoji Kawai, Takashi Okada

    Small Methods     2025.1

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Achieving safe and efficient gene therapy hinges upon the inspection of genomes enclosed within individual nano‐carriers to mitigate potential health risks associated with empty or fragment‐filled vectors. Here solid‐state nanopore sensing is reported for identifications of intermediate adeno‐associated virus (AAV) vectors in liquid. The method exploits the phenomenon of translocation slowdown induced by the viscosity of salt water‐organic mixtures. This enables real‐time ionic current measurements allowing precise tracking of the electroosmotic flow‐driven motions of recombinant AAV vectors in a nanopore. The resulting ionic signals facilitate discrimination between replicative intermediates carrying ssDNA fragments and its full vector counterparts based on genome length‐derived subtle nanometer differences in the viral diameters. This rapid and non‐destructive means of genome analysis within virus capsids provides a promising avenue toward a robust methodology for ensuring the integrity of AAV vectors before administration.

    DOI： 10.1002/smtd.202401321

    Open Access

  3. A multiplex microfluidic device to detect miRNAs for diagnosis of plant growth status Reviewed Open Access

    Yaichi Kawakatsu, Mitsuo Hara, Ken-ichi Kurotani, Akihide Arima, Yoshinobu Baba, Michitaka Notaguchi

    Horticulture Research     2024.11

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    Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    DOI： 10.1093/hr/uhae323

    Open Access

  4. Identifying Viral Vector Characteristics by Nanopore Sensing Reviewed

    Makusu Tsutsui, Mikako Wada, Akihide Arima, Yuji Tsunekawa, Takako Sasaki, Kenji Sakamoto, Kazumichi Yokota, Yoshinobu Baba, Tomoji Kawai, Takashi Okada

    ACS Nano   Vol. 18 ( 24 ) page： 15695 - 15704   2024.6

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    Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acsnano.4c01888

  5. Microfluidic Device for Simple Diagnosis of Plant Growth Condition by Detecting miRNAs from Filtered Plant Extracts Reviewed Open Access

    Yaichi Kawakatsu, Ryo Okada, Mitsuo Hara, Hiroki Tsutsui, Naoki Yanagisawa, Tetsuya Higashiyama, Akihide Arima, Yoshinobu Baba, Ken-ichi Kurotani, Michitaka Notaguchi

    Plant Phenomics   Vol. 6   page： 0162   2024.4

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    Publishing type：Research paper (scientific journal)   Publisher：American Association for the Advancement of Science (AAAS)  

    Plants are exposed to a variety of environmental stress, and starvation of inorganic phosphorus can be a major constraint in crop production. In plants, in response to phosphate deficiency in soil, miR399, a type of microRNA (miRNA), is up-regulated. By detecting miR399, the early diagnosis of phosphorus deficiency stress in plants can be accomplished. However, general miRNA detection methods require complicated experimental manipulations. Therefore, simple and rapid miRNA detection methods are required for early plant nutritional diagnosis. For the simple detection of miR399, microfluidic technology is suitable for point-of-care applications because of its ability to detect target molecules in small amounts in a short time and with simple manipulation. In this study, we developed a microfluidic device to detect miRNAs from filtered plant extracts for the easy diagnosis of plant growth conditions. To fabricate the microfluidic device, verification of the amine-terminated glass as the basis of the device and the DNA probe immobilization method on the glass was conducted. In this device, the target miRNAs were detected by fluorescence of sandwich hybridization in a microfluidic channel. For plant stress diagnostics using a microfluidic device, we developed a protocol for miRNA detection by validating the sample preparation buffer, filtering, and signal amplification. Using this system, endogenous sly-miR399 in tomatoes, which is expressed in response to phosphorus deficiency, was detected before the appearance of stress symptoms. This early diagnosis system of plant growth conditions has a potential to improve food production and sustainability through cultivation management.

    DOI： 10.34133/plantphenomics.0162

    Open Access

  6. Development of Single-Bioparticle Analysis Using Nano/Micropore Devices Invited Reviewed Open Access

    Akihide Arima

    Bunseki Kagaku   Vol. 72 ( 7・8 ) page： 257 - 263   2023.7

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  7. Ionic heat dissipation in solid-state pores Reviewed Open Access

    Makusu Tsutsui, Akihide Arima, Kazumichi Yokota, Yoshinobu Baba, Tomoji Kawai

    Science Advances   Vol. 8 ( 6 ) page： eabl7002   2022.1

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  8. Detecting Single Molecule Deoxyribonucleic Acid in a Cell Using a Three‐Dimensionally Integrated Nanopore Reviewed

    Makusu Tsutsui, Kazumichi Yokota, Akihide Arima, Takashi Washio, Yoshinobu Baba, Tomoji Kawai

    Small Methods   Vol. 5 ( 9 ) page： 2100542 - 2100542   2021.8

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1002/smtd.202100542

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/smtd.202100542

  9. デジタル・トランスフォーメーションで変わる医療: ナノバイオデバイス、量子科学技術とAIが拓く未来医療

    有馬 彰秀, 馬場 嘉信

    Pharm Tech. Japan   Vol. 37 ( 5 ) page： 85 - 90   2021.4

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    Language：Japanese   Publisher：(株)じほう  

  10. Oxide Nanowire Microfluidic Devices for Capturing Single-stranded DNAs Reviewed Open Access

    Marina MUSA, Takao YASUI, Zetao ZHU, Kazuki NAGASHIMA, Miki ONO, Quanli LIU, Hiromi TAKAHASHI, Taisuke SHIMADA, Akihide ARIMA, Takeshi YANAGIDA, Yoshinobu BABA

    Analytical Sciences   Vol. 37 ( 8 ) page： 1139 - 1145   2021.1

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    Publishing type：Research paper (scientific journal)   Publisher：Japan Society for Analytical Chemistry  

    DOI： 10.2116/analsci.20p421

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    CiNii Research

  11. ZnO/SiO2 core/shell nanowires for capturing CpG rich single-stranded DNAs Reviewed International journal

    Marina Musa, Takao Yasui, Kazuki Nagashima, Masafumi Horiuchi, Zetao Zhu, Quanli Liu, Taisuke Shimada, Akihide Arima, Takeshi Yanagida, Yoshinobu Baba

    Analytical Methods   Vol. 13 ( 3 ) page： 337 - 344   2020.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    Atomic layer deposition (ALD) is capable of providing an ultrathin layer on high-aspect ratio structures with good conformality and tunable film properties. In this research, we modified the surface of ZnO nanowires through ALD for the fabrication of a ZnO/SiO2 (core/shell) nanowire microfluidic device which we utilized for the capture of CpG-rich single-stranded DNAs (ssDNA). Structural changes of the nanowires while varying the number of ALD cycles were evaluated by statistical analysis and their relationship with the capture efficiency was investigated. We hypothesized that finding the optimum number of ALD cycles would be crucial to ensure adequate coating for successful tuning to the desired surface properties, besides promoting a sufficient trapping region with optimal spacing size for capturing the ssDNAs as the biomolecules traverse through the dispersed nanowires. Using the optimal condition, we achieved high capture efficiency of ssDNAs (86.7%) which showed good potential to be further extended for the analysis of CpG sites in cancer-related genes. This finding is beneficial to the future design of core/shell nanowires for capturing ssDNAs in biomedical applications.

    DOI： 10.1039/d0ay02138e

    Web of Science

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  12. Solid-State Nanopore Platform Integrated with Machine Learning for Digital Diagnosis of Virus Infection Invited Reviewed International journal

    Akihide Arima, Makusu Tsutsui, Takashi Washio, Yoshinobu Baba, Tomoji Kawai

    Analytical Chemistry   Vol. 93 ( 1 ) page： 215 - 227   2020.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acs.analchem.0c04353

    Web of Science

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  13. ナノポアデバイスによる単一生体粒子分析

    有馬 彰秀

    化学とマイクロ・ナノシステム   Vol. 19 ( 2 ) page： 44 - 45   2020.10

  14. Machine learning-driven electronic identifications of single pathogenic bacteria Reviewed Open Access

    Shota Hattori, Rintaro Sekido, Iat Wai Leong, Makusu Tsutsui, Akihide Arima, Masayoshi Tanaka, Kazumichi Yokota, Takashi Washio, Tomoji Kawai, Mina Okochi

    Scientific Reports   Vol. 10 ( 1 ) page： 15525   2020.9

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    <title>Abstract</title>
    A rapid method for screening pathogens can revolutionize health care by enabling infection control through medication before symptom. Here we report on label-free single-cell identifications of clinically-important pathogenic bacteria by using a polymer-integrated low thickness-to-diameter aspect ratio pore and machine learning-driven resistive pulse analyses. A high-spatiotemporal resolution of this electrical sensor enabled to observe galvanotactic response intrinsic to the microbes during their translocation. We demonstrated discrimination of the cellular motility via signal pattern classifications in a high-dimensional feature space. As the detection-to-decision can be completed within milliseconds, the present technique may be used for real-time screening of pathogenic bacteria for environmental and medical applications.

    DOI： 10.1038/s41598-020-72508-3

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    Web of Science

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    Other Link： http://www.nature.com/articles/s41598-020-72508-3

  15. Ammonia-Induced Seed Layer Transformations in a Hydrothermal Growth Process of Zinc Oxide Nanowires Reviewed Open Access

    Quanli Liu, Takao Yasui, Kazuki Nagashima, Takeshi Yanagida, Mitsuo Hara, Masafumi Horiuchi, Zetao Zhu, Hiromi Takahashi, Taisuke Shimada, Akihide Arima, Yoshinobu Baba

    The Journal of Physical Chemistry C   Vol. 124 ( 37 ) page： 20563 - 20568   2020.9

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    Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acs.jpcc.0c05490

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    Web of Science

    Scopus

  16. Digital Pathology Platform for Respiratory Tract Infection Diagnosis via Multiplex Single-Particle Detections Reviewed International journal

    Akihide Arima, Makusu Tsutsui, Takeshi Yoshida, Kenji Tatematsu, Tomoko Yamazaki, Kazumichi Yokota, Shun’ichi Kuroda, Takashi Washio, Yoshinobu Baba, Tomoji Kawai

    ACS Sensors   Vol. 5 ( 11 ) page： 3398 - 3403   2020.9

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    The variability of bioparticles remains a key barrier to realizing the competent potential of nanoscale detection into a digital diagnosis of an extraneous object that causes an infectious disease. Here, we report label-free virus identification based on machine-learning classification. Single virus particles were detected using nanopores, and resistive-pulse waveforms were analyzed multilaterally using artificial intelligence. In the discrimination, over 99% accuracy for five different virus species was demonstrated. This advance is accessed through the classification of virus-derived ionic current signal patterns reflecting their intrinsic physical properties in a high-dimensional feature space. Moreover, consideration of viral similarity based on the accuracies indicates the contributing factors in the recognitions. The present findings offer the prospect of a novel surveillance system applicable to detection of multiple viruses including new strains.

    DOI： 10.1021/acssensors.0c01564

    Web of Science

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  17. Photolithographically Constructed Single ZnO Nanowire Device and Its Ultraviolet Photoresponse Open Access

    Liu Quanli, Yasui Takao, Nagashima Kazuki, Yanagida Takeshi, Horiuchi Masafumi, Zhu Zetao, Takahashi Hiromi, Shimada Taisuke, Arima Akihide, Baba Yoshinobu

    ANALYTICAL SCIENCES   Vol. 36 ( 9 ) page： 1125 - 1129   2020.9

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  18. Photolithographically Constructed Single ZnO Nanowire Device and Its Ultraviolet Photoresponse. Reviewed Open Access

    Quanli Liu, Takao Yasui, Kazuki Nagashima, Takeshi Yanagida, Masafumi Horiuchi, Zetao Zhu, Hiromi Takahashi, Taisuke Shimada, Akihide Arima, Yoshinobu Baba

    Analytical sciences   Vol. 36 ( 9 ) page： 1125 - 1129   2020.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    A sparse ZnO nanowire array with aspect ratio of ca. 120 and growth rate of 1 μm/h was synthesized by controlling the density of seeds at the initial stage of nanowire growth. The spatially-separated nanowires were cut off from the growth substrate without breaking, and thus were useful in the construction of a single-nanowire device by photolithography. The device exhibited a linear current-voltage characteristic associated with ohmic contact between ZnO nanowire and electrodes. The device further demonstrated a reliable photoresponse with an IUV/Idark of ∼100 to ultraviolet light irradiation.

    DOI： 10.2116/analsci.20N002

    Open Access

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    CiNii Research

  19. Tailoring Dielectric Surface Charge via Atomic Layer Thickness Reviewed

    ACS Applied Materials & Interfaces   Vol. 12 ( 4 ) page： 5025 - 5030   2020.1

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  20. Metal oxide nanowires microfluidic devices as potential tool for DNA methylation mapping

    Musa M.

    MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences     page： 1093 - 1094   2020

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    Publisher：MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences  

    Scopus

  21. Solid-State Nanopore Time-of-Flight Mass Spectrometer Reviewed

    ACS Sensors   Vol. 4 ( 11 ) page： 2974 - 2979   2019.11

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  22. High-throughput single nanoparticle detection using a feed-through channel-integrated nanopore. Reviewed

    Tsutsui M, Yamazaki T, Tatematsu K, Yokota K, Esaki Y, Kubo Y, Deguchi H, Arima A, Kuroda S, Kawai T

    Nanoscale   Vol. 11 ( 43 ) page： 20475 - 20484   2019.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    <p>Feeding viral solution to a solid-state nanopore through a controlled fluid-flow enables high-throughput single-virus detection.</p>

    DOI： 10.1039/C9NR07039G

    PubMed

  23. High-throughput single-particle detections using a dual-height-channel-integrated pore Reviewed Open Access

    Wataru Tonomura, Makusu Tsutsui, Akihide Arima, Kazumichi Yokota, Masater Taniguchi, Takashi Washio, Tomoji Kawai

    Lab on a Chip   Vol. 19 ( 8 ) page： 1352 - 1358   2019.3

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  24. Volume discrimination of nanoparticles via electrical trapping using nanopores Reviewed Open Access

    Akihide Arima, Makusu Tsutsui, Masateru Taniguchi

    Journal of Nanobiotechnology   Vol. 17 ( 1 ) page： 40   2019.3

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1186/s12951-019-0471-5

    Open Access

    PubMed

    Other Link： http://link.springer.com/article/10.1186/s12951-019-0471-5/fulltext.html

  25. Silicon substrate effects on ionic current blockade in solid-state nanopores Reviewed Open Access

    Makusu Tsutsui, Kazumichi Yokota, Tomoko Nakada, Akihide Arima, Wataru Tonomura, Masateru Taniguchi, Takashi Washio, Tomoji Kawai

    Nanoscale   Vol. 11 ( 10 ) page： 4190 - 4197   2019.2

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  26. Electric field interference and bimodal particle translocation in nano-integrated multipores Reviewed Open Access

    Makusu Tsutsui, Kazumichi Yokota, Tomoko Nakada, Akihide Arima, Wataru Tonomura, Masateru Taniguchi, Takashi Washio, Tomoji Kawai

    Nanoscale   Vol. 11 ( 16 ) page： 7547 - 7553   2019.1

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  27. Identifying multiple viral species at a single particle level using a combination of nanopores and machine leaning approach

    Arima A.

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019     page： 1238 - 1239   2019

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    Publisher：23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019  

    Scopus

  28. Particle Capture in Solid-State Multipores Reviewed

    Makusu Tsutsui, Kazumichi Yokota, Tomoko Nakada, Akihide Arima, Wataru Tonomura, Masateru Taniguchi, Takashi Washio, Tomoji Kawai

    ACS Sensors   Vol. 3 ( 12 ) page： 2693 - 2701   2018.11

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  29. Temporal Response of Ionic Current Blockade in Solid-State Nanopores Reviewed

    Makusu Tsutsui, Kazumichi Yokota, Akihide Arima, Wataru Tonomura, Masateru Taniguchi, Takashi Washio, Tomoji Kawai

    ACS Applied Materials & Interfaces   Vol. 10 ( 40 ) page： 34751 - 34757   2018.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acsami.8b11819

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  30. 糖鎖修飾ナノポアによるウイルス検出と感染能評価 Invited

    有馬彰秀, 堀口諭吉, 筒井真楠, 殿村渉, 横田一道, 谷口正輝, 宮原裕二, 川合知二

    化学とマイクロ・ナノシステム   Vol. 17 ( 1 ) page： 27 - 30   2018.3

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    Language：Japanese  

  31. Identification of Individual Bacterial Cells through the Intermolecular Interactions with Peptide-Functionalized Solid-State Pores. Reviewed International journal

    Makusu Tsutsui, Masayoshi Tanaka, Takahiro Marui, Kazumichi Yokota, Takeshi Yoshida, Akihide Arima, Wataru Tonomura, Masateru Taniguchi, Takashi Washio, Mina Okochi, Tomoji Kawai

    Analytical chemistry   Vol. 90 ( 3 ) page： 1511 - 1515   2018.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    Bioinspired pore sensing for selective detection of flagellated bacteria was investigated. The Au micropore wall surface was modified with a synthetic peptide designed from toll-like receptor 5 (TLR5) to mimic the pathogen-recognition capability. We found that intermolecular interactions between the TLR5-derived recognition peptides and flagella induce ligand-specific perturbations in the translocation dynamics of Escherichia coli, which facilitated the discrimination between the wild-type and flagellin-deletion mutant (ΔfliC) by the resistive pulse patterns thereby demonstrating the sensing of bacteria at a single-cell level. These results provide a novel concept of utilizing weak intermolecular interactions as a recognition probes for single-cell microbial identification.

    DOI： 10.1021/acs.analchem.7b04950

    PubMed

  32. Identifying Single Viruses Using Biorecognition Solid-State Nanopores Reviewed

    Arima, A., Harlisa, I.H., Yoshida, T., Tsutsui, M., Tanaka, M., Yokota, K., Tonomura, W., Yasuda, J., Taniguchi, M., Washio, T., Okochi, M., Kawai, T.

    Journal of the American Chemical Society   Vol. 140 ( 48 ) page： 16834 - 16841   2018

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/jacs.8b10854

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  33. Selective detections of single-viruses using solid-state nanopores Reviewed Open Access

    Arima, A., Tsutsui, M., Harlisa, I.H., Yoshida, T., Tanaka, M., Yokota, K., Tonomura, W., Taniguchi, M., Okochi, M., Washio, T., Kawai, T.

    Scientific Reports   Vol. 8 ( 1 ) page： 16305   2018

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-018-34665-4

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  34. Discriminating single-bacterial shape using low-aspect-ratio pores Reviewed Open Access

    Makusu Tsutsui, Takeshi Yoshida, Kazumichi Yokota, Hirotoshi Yasaki, Takao Yasui, Akihide Arima, Wataru Tonomura, Kazuki Nagashima, Takeshi Yanagida, Noritada Kaji, Masateru Taniguchi, Takashi Washio, Yoshinobu Baba, Tomoji Kawai

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page： 17371   2017.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：NATURE PUBLISHING GROUP  

    Conventional concepts of resistive pulse analysis is to discriminate particles in liquid by the difference in their size through comparing the amount of ionic current blockage. In sharp contrast, we herein report a proof-of-concept demonstration of the shape sensing capability of solid-state pore sensors by leveraging the synergy between nanopore technology and machine learning. We found ionic current spikes of similar patterns for two bacteria reflecting the closely resembled morphology and size in an ultra-low thickness-to-diameter aspect-ratio pore. We examined the feasibility of a machine learning strategy to pattern-analyse the sub-nanoampere corrugations in each ionic current waveform and identify characteristic electrical signatures signifying nanoscopic differences in the microbial shape, thereby demonstrating discrimination of single-bacterial cells with accuracy up to 90%. This data-analytics-driven microporescopy capability opens new applications of resistive pulse analyses for screening viruses and bacteria by their unique morphologies at a single-particle level.

    DOI： 10.1038/s41598-017-17443-6

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    PubMed

  35. Rapid structural analysis of nanomaterials in aqueous solutions Reviewed Open Access

    Sou Ryuzaki, Makusu Tsutsui, Yuhui He, Kazumichi Yokota, Akihide Arima, Takanori Morikawa, Masateru Taniguchi, Tomoji Kawai

    NANOTECHNOLOGY   Vol. 28 ( 15 ) page： 155501-1 - 155501-8   2017.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：IOP PUBLISHING LTD  

    Rapid structural analysis of nanoscale matter in a liquid environment represents innovative technologies that reveal the identities and functions of biologically important molecules. However, there is currently no method with high spatio-temporal resolution that can scan individual particles in solutions to gain structural information. Here we report the development of a nanopore platform realizing quantitative structural analysis for suspended nanomaterials in solutions with a high z-axis and xy-plane spatial resolution of 35.8 +/- 1.1 and 12 nm, respectively. We used a low thickness-to-diameter aspect ratio pore architecture for achieving cross sectional areas of analyte (i.e. tomograms). Combining this with multiphysics simulation methods to translate ionic current data into tomograms, we demonstrated rapid structural analysis of single polystyrene (Pst) beads and single dumbbell-like Pst beads in aqueous solutions.

    DOI： 10.1088/1361-6528/aa5e66

    Open Access

    Web of Science

    PubMed

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Books 6

  1. AIとバイオの融合最前線

    有馬 彰秀, 筒井 真楠, 川合 知二, 馬場 嘉信（第3章 医療との融合 5 AIを利用したナノポアによるインテリジェントセンシング）

    シーエムシー出版  2025.5 

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    Total pages：229   Responsible for pages：93-99  

  2. AIと固体ナノポアセンサによるウイルス検査

    有馬 彰秀, 筒井 真楠, 鷲尾 隆, 馬場 嘉信, 川合 知二

    生物工学会誌, 101 (8), 439-442.  2023.8 

  3. Ultra-high performance analysis of extracellular fine particles using nanowire/nanopore technology

    Yoshinobu Baba, Akihide Arima, Yasui Takao

    2023.4 

  4. 最先端ナノライフシステム研究(最先端ナノライフシステム研究編集委員会 編)

    有馬 彰秀, 筒井真楠 (担当: 第Ⅳ編 1章 ナノ・マイクロポアセンサを用いた単一生体粒子分析)（第Ⅳ編 1章 ナノ・マイ クロポアセンサを用いた単一生体粒子分析）

    丸善プラネット  2022.3 

  5. 医用工学ハンドブック(編集: 佐久間 一郎, 秋吉 一成, 津本 浩平)

    馬場嘉信, 安井隆雄, 有馬彰秀(担当: 第2編 第5章 ナノバイオデバイスによる単一生体粒子分析)（第2編 第5章 ナノバイオデバイスによる単一生体粒子）

    エヌ・ティー・エス  2022.2  （ ISBN:4860437357 ）

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    Total pages：544  

    ASIN

  6. AI・ナノ・量子による超高感度・迅速バイオセンシング : 超早期パンデミック検査・超早期診断・POCTから健康長寿社会へ(監修: 馬場 嘉信, 柳田 剛, 加地 範匡)

    有馬 彰秀, 筒井 真楠(担当: 第III編第10章 ナノスケールセンシングと人工知能の融合による ウイルス・細菌の変異・薬剤耐性予測システム創出の展望)

    シーエムシー出版  2021.8  （ ISBN:9784781316093 ）

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    Total pages：vii, 244p   Language：Japanese

    CiNii Research

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MISC 24

  1. Evaluation of single-cell ionic transport using solid-state micropores

    有馬彰秀, 山内晴加, 筒井真楠, 川合知二, 馬場嘉信

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   Vol. 70th   2023

  2. Ionic local heating of a nanopore

    筒井真楠, 有馬彰秀, 横田一道, 馬場嘉信, 川合知二

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   Vol. 69th   2022

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  3. Optical/electrical simultaneous detections of single cell using micropore devices

    有馬彰秀, 山内晴加, 筒井真楠, 馬場嘉信

    日本化学会春季年会講演予稿集(Web)   Vol. 102nd   2022

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  4. Construction of nanowire devices for single extracellular vesicles measurement

    鈴木駿介, 安井隆雄, KIM Soo Hyeon, 嶋田泰佑, 有馬彰秀, 馬場嘉信

    日本化学会春季年会講演予稿集(Web)   Vol. 102nd   2022

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  5. 3D integrated nanopore for single cell lysis to single-molecule DNA detections

    筒井真楠, 横田一道, 有馬彰秀, 鷲尾隆, 馬場嘉信, 川合知二

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   Vol. 69th   2022

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  6. 顕微観察とイオン電流計測による単一細胞の状態評価

    山内晴加, 有馬彰秀, 安井隆雄, 嶋田泰佑, 湯川博, 小野島大介, 馬場嘉信

    中部化学関係学協会支部連合秋季大会講演予稿集   Vol. 52nd (CD-ROM)   2021

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  7. オルガノイド由来細胞外小胞の捕捉と膜タンパク質計測

    鈴木駿介, 安井隆雄, 夏目敦至, 大岡史治, 山崎慎太郎, 青木恒介, 北野詳太郎, 有馬彰秀, 嶋田泰佑, 長島一樹, 柳田剛, 馬場嘉信

    中部化学関係学協会支部連合秋季大会講演予稿集   Vol. 52nd (CD-ROM)   2021

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  8. Measurement of brain tumor organoid-derived extracellular vesicles using nanowires

    鈴木駿介, 安井隆雄, 夏目敦至, 大岡史治, 山崎慎太郎, 青木恒介, 北野詳太郎, 有馬彰秀, 嶋田泰佑, 長島一樹, 柳田剛, 馬場嘉信

    日本化学会春季年会講演予稿集(Web)   Vol. 101st   2021

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  9. マイクロポアデバイスを用いた1細胞の電気的捕捉による状態評価

    山内晴加, 有馬彰秀, 筒井真楠, 安井隆雄, 安井隆雄, 安井隆雄, 嶋田泰佑, 湯川博, 湯川博, 小野島大介, 馬場嘉信, 馬場嘉信, 馬場嘉信

    化学とマイクロ・ナノシステム学会研究会講演要旨集(CD-ROM)   Vol. 44th   2021

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  10. Discrimination and separation of single-cells by electrical capture using a micropore device

    山内晴加, 有馬彰秀, 安井隆雄, 嶋田泰佑, 湯川博, 小野島大介, 馬場嘉信

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   Vol. 82nd   2021

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  11. マイクロポアデバイスを用いた1細胞解析に向けた基礎検討

    有馬彰秀, 山内晴加, 筒井真楠, 安井隆雄, 湯川博嶋田泰佑, 小野島大介, 馬場嘉信

    日本分析化学会年会講演要旨集(Web)   Vol. 70th   2021

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  12. Metal oxide nanowires microfluidic devices as potential tool for DNA methylation mapping Reviewed

    Marina Musa, Takao Yasui, Taisuke Shimada, Akihide Arima, Yoshinobu Baba

    24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2020)     page： 1093 - 1094   2020

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    Publishing type：Article, review, commentary, editorial, etc. (international conference proceedings)  

  13. Discriminating drug-resistant bacteria via ionic current measurement of electric field response at single particle level

    吉川碧海, 安井隆雄, 嶋田泰佑, 有馬彰秀, 山崎聖司, 西野邦彦, 柳田剛, 長島一樹, 川合知二, 馬場嘉信

    日本化学会春季年会講演予稿集(CD-ROM)   Vol. 100th   2020

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  14. ナノポアデバイスを用いた単一生体粒子分析

    有馬彰秀, 筒井真楠, 吉田剛, 横田一道, 立松健司, 山崎智子, 黒田俊一, 谷口正輝, 鷲尾隆, 川合知二, 馬場嘉信

    Molecular Electronics and Bioelectronics   Vol. 31 ( 2 )   2020

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  15. ナノポアデバイスを用いた単一生体粒子分析 (応用物理学会 有機分子・バイオエレクトロニクス分科会研究会 ここまで進んだ有機分子・バイオエレクトロニクス研究)

    有馬 彰秀, 筒井 真楠, 吉田 剛, 横田 一道, 立松 健司, 山﨑 智子, 黒田 俊一, 谷口 正輝, 鷲尾 隆, 川合 知二, 馬場 嘉信

    Molecular electronics and bioelectronics = 応用物理学会,有機分子・バイオエレクトロニクス分科会会誌   Vol. 31 ( 2 ) page： 93 - 96   2020

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    Language：Japanese   Publisher：応用物理学会有機分子・バイオエレクトロニクス分科会  

    CiNii Research

  16. Creation of an immune learning field with extracellular vesicle-capturing nanowires for induction of immune cell evolution

    大野美樹, 安井隆雄, 夏目敦至, 嶋田泰佑, 有馬彰秀, 青木恒介, 北野詳太郎, 山崎慎太郎, 馬場嘉信

    日本化学会春季年会講演予稿集(CD-ROM)   Vol. 100th   2020

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  17. Identifying multiple viral species at a single particle level using a combination of nanopores and machine learning approach Reviewed

    Akihide Arima, Makusu Tsutsui, Yoshida Takeshi, Kazumichi Yokota, Wataru Tonomura, Takao Yasui, Taisuke Shimada, Tomoko Yamazaki, Kenji Tatematsu, Shunichi Kuroda, Masateru Taniguchi, Takashi Washio, Tomoji Kawai, Yoshinobu Baba

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)     page： 1238 - 1239   2019

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    Publishing type：Article, review, commentary, editorial, etc. (international conference proceedings)  

  18. 機械学習と分子認識ナノポアを用いた1ウイルス識別

    筒井真楠, 有馬彰秀, 吉田剛, 横田一道, 殿村渉, 谷口正輝, 鷲尾隆, 川合知二, HARLISA Ilva Hanun, 田中祐圭, 大河内美奈

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   Vol. 66th   2019

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  19. ナノバイオデバイスと機械学習の融合による多項目ウイルス識別

    有馬彰秀, 筒井真楠, 殿村渉, 横田一道, 安井隆雄, 嶋田泰佑, 山崎智子, 立松健司, 黒田俊一, 谷口正輝, 鷲尾隆, 川合知二, 馬場嘉信

    化学とマイクロ・ナノシステム学会研究会講演要旨集   Vol. 39th   2019

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  20. 高感度検出に向けたペプチド修飾ポアセンサの開発

    服部翔太, 田中祐圭, 大河内美奈, 有馬彰秀, 筒井真楠, 谷口正輝

    化学工学会秋季大会研究発表講演要旨集(CD-ROM)   Vol. 50th   2018

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  21. ナノポア計測と機械学習によるインフルエンザウイルス識別

    筒井真楠, 有馬彰秀, 吉田剛, 横田一道, 殿村渉, 谷口正輝, 鷲尾隆, 川合知二, ILVA Harlisa, 田中祐圭, 大河内美奈

    日本化学会春季年会講演予稿集(CD-ROM)   Vol. 98th   2018

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  22. ペプチド修飾ポアセンサを用いた微生物判別

    服部翔太, 田中祐圭, 有馬彰秀, 筒井真楠, 谷口正輝, 大河内美奈

    電気化学会大会講演要旨集(CD-ROM)   Vol. 85th   2018

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  23. 微生物結合ペプチドを修飾したポアセンサにおけるイオン電流の応答解析

    服部翔太, イルファ ハヌンハルリサ, 丸井貴皓, 田中祐圭, 大河内美奈, 有馬彰秀, 筒井真楠, 谷口正輝, 鷲尾隆, 川合知二

    化学工学会年会研究発表講演要旨集(CD-ROM)   Vol. 82nd   2017

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  24. 微生物判別デバイスの開発に向けたペプチド探索

    服部翔太, 田中祐圭, 有馬彰秀, 筒井真楠, 谷口正輝, 鷲尾隆, 川合知二, 大河内美奈

    化学とマイクロ・ナノシステム学会研究会講演要旨集   Vol. 35th   2017

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KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. イオン性ポリマー修飾積層ナノポアを用いた少数分子反応解析法の創成

    2024.4 - 2027.3

    日本学術振興会  基盤研究(B) 

    有馬 彰秀, 筒井 真楠

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    Authorship：Principal investigator 

  2. Development of Nanopore Technology for Evaluating Polymer Brush Growth

    2024.2 - 2026.6

    Toshiaki Ogasawara Memorial Foundation  General Research Grant 

  3. マイクロポアデバイスを用いた顕微観察と微小電流計測に基づく1細胞分析法の開発

    2023.4 - 2024.3

    公益財団法人 内藤科学技術振興財団  研究助成 

    有馬 彰秀

  4. ナノバイオデバイスを用いた1細胞におけるイオン輸送能の包括的分析

    2022.4 - 2024.3

    公益財団法人 旭硝子財団  2022年度 研究奨励 

    有馬 彰秀

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    Authorship：Principal investigator 

  5. 機能性ナノチャネル構造を用いた網羅的1細胞解析法の創成

    2019.4 - 2022.3

    日本学術振興会  基盤研究(B)  基盤研究(B)

    有馬 彰秀, 筒井真楠

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    Authorship：Principal investigator  Grant type：Competitive

  6. ナノポアトラップ法を利用した包括的１細胞解析法の創成

    2017.4 - 2019.3

    日本学術振興会  若手研究(B)  若手研究(B)

    有馬 彰秀

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    Authorship：Principal investigator  Grant type：Competitive

  7. ナノポアトラップ法を利用したナノキャリアの電気的捕捉と融合による微小反応場の創出

    2016.4 - 2017.3

    日本学術振興会  研究活動スタート支援  研究活動スタート支援

    有馬 彰秀

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    Authorship：Principal investigator  Grant type：Competitive

  8. 多重ナノ電極組込ウェルデバイスによる単一生体分子形態識別法の創成

    2015.4 - 2016.3

    科学研究費補助金 

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To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲

Industrial property rights 3

  1. 流路

    筒井 真楠, 横田 一道, 有馬 彰秀, 殿村 渉, 谷口 正輝, 鷲尾 隆, 川合 知二

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    Application no：特願2018-131885  Date applied：2018.7

  2. 流路デバイスおよび微粒子濃縮方法

    殿村 渉, 筒井 真楠, 横田 一道, 有馬 彰秀, 谷口 正輝, 川合 知二

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    Application no：特願2017-100218  Date applied：2017.5

  3. 筒井 真楠, 横田 一道, 有馬 彰秀, 谷口 正輝, 川合 知二

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    Application no：特願2018-241363 

To the head of Industrial property rights.▲
 

Teaching Experience (Off-campus) 5

  1. 化学生命工学実験1

    （Nagoya University）

  2. 基礎セミナー

    （Nagoya University）

  3. 化学生命工学実験3

    （Nagoya University）

  4. 分子生命化学基礎論

    （Nagoya University）

  5. ナノバイオ計測化学

    （Nagoya University）

To the head of Teaching Experience (Off-campus).▲