所属
医学部附属病院 整形外科 講師
大学院担当
大学院医学系研究科
職名
講師
アサイ シュウジ
浅井 秀司
ASAI Shuji
学位 1
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博士（医学） （ 2013年5月 名古屋大学 ）
研究分野 1
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ライフサイエンス / 整形外科学
学歴 2
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名古屋大学 医学系研究科
- 2013年5月
国名： 日本国
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名古屋大学 医学部
- 2002年3月
国名： 日本国
所属学協会 2
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日本リウマチ学会
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日本整形外科学会
論文 67
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Periprosthetic humeral fracture revision using a massive allograft in a patient with rheumatoid arthritis: A case report 査読有り
Kishimoto Kenji, Kojima Toshihisa, Takahashi Nobunori, Asai Shuji, Terabe Kenya, Suzuki Mochihito, Ohashi Yoshifumi, Kihira Daisuke, Maeda Masataka, Tatebe Masahiro, Imagama Shiro
MODERN RHEUMATOLOGY CASE REPORTS 2023年1月
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Late-onset rheumatoid arthritis registry study, LORIS study: study protocol and design 査読有り
Kojima Masayo, Kawahito Yutaka, Sugihara Takahiko, Kojima Toshihisa, Harada Ryozo, Hirata Shintaro, Hashimoto Motomu, Hidaka Toshihiko, Ishikawa Hajime, Ito Hiromu, Kishimoto Mitsumasa, Kaneko Yuko, Matsui Kazuo, Matsui Toshihiro, Matsushita Isao, Morinobu Akio, Nishida Keiichiro, Tanaka Eiichi, Abe Asami, Ishitoku Michinori, Asai Shuji, Kida Takashi, Onishi Akira, Takanashi Satoshi, Harigai Masayoshi
BMC RHEUMATOLOGY 6 巻 ( 1 ) 2022年12月
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Locomotive syndrome in rheumatoid arthritis patients during the COVID-19 pandemic 査読有り
Sobue Yasumori, Suzuki Mochihito, Ohashi Yoshifumi, Koshima Hiroshi, Okui Nobuyuki, Funahashi Koji, Ishikawa Hisato, Inoue Hidenori, Kojima Masayo, Asai Shuji, Terabe Kenya, Hattori Kyosuke, Kishimoto Kenji, Takahashi Nobunori, Imagama Shiro, Kojima Toshihisa
NAGOYA JOURNAL OF MEDICAL SCIENCE 84 巻 ( 4 ) 頁： 799 - 812 2022年11月
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Association between locomotive syndrome and methotrexate discontinuation due to adverse events in rheumatoid arthritis patients: A retrospective observational study 査読有り
Sobue Yasumori, Suzuki Mochihito, Ohashi Yoshifumi, Koshima Hiroshi, Okui Nobuyuki, Funahashi Koji, Ishikawa Hisato, Inoue Hidenori, Kojima Masayo, Asai Shuji, Terabe Kenya, Hattori Kyosuke, Kishimoto Kenji, Takahashi Nobunori, Imagama Shiro, Kojima Toshihisa
GERIATRICS & GERONTOLOGY INTERNATIONAL 22 巻 ( 10 ) 頁： 904 - 906 2022年10月
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Reasons and risk factors for discontinuation of treatment with any biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: A long-term observational study 査読有り
Terabe Kenya, Takahashi Nobunori, Asai Shuji, Hirano Yuji, Kanayama Yasuhide, Yabe Yuichiro, Oguchi Takeshi, Fujibayashi Takayoshi, Ishikawa Hisato, Hanabayashi Masahiro, Hattori Yosuke, Suzuki Mochihito, Kishimoto Kenji, Ohashi Yoshifumi, Imaizumi Takahiro, Imagama Shiro, Kojima Toshihisa
MODERN RHEUMATOLOGY 2022年8月
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Changes in perioperative C-reactive protein levels in patients with rheumatoid arthritis undergoing total knee arthroplasty in the biologic era
Kishimoto Kenji, Asai Shuji, Takahashi Nobunori, Terabe Kenya, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki, Kojima Toshihisa
NAGOYA JOURNAL OF MEDICAL SCIENCE 84 巻 ( 2 ) 頁： 286 - 300 2022年5月
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Influence of frailty on patient global assessment in rheumatoid arthritis 査読有り
Suzuki Mochihito, Asai Shuji, Sobue Yasumori, Ohashi Yoshifumi, Koshima Hiroshi, Okui Nobuyuki, Ishikawa Hisato, Takahashi Nobunori, Terabe Kenya, Kishimoto Kenji, Hattori Kyosuke, Imagama Shiro, Kojima Toshihisa
GERIATRICS & GERONTOLOGY INTERNATIONAL 22 巻 ( 5 ) 頁： 399 - 404 2022年5月
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Factors associated with frailty in rheumatoid arthritis patients with decreased renal function 査読有り
Ohashi Yoshifumi, Takahashi Nobunori, Sobue Yasumori, Suzuki Mochihito, Hattori Kyosuke, Kishimoto Kenji, Terabe Kenya, Asai Syuji, Kojima Toshihisa, Kojima Masayo, Imagama Shiro
MODERN RHEUMATOLOGY 2022年4月
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Effectiveness of Tacrolimus Concomitant with Biological Disease-Modifying Anti-Rheumatic Drugs in Patients with Rheumatoid Arthritis. 査読有り
Terabe K, Takahashi N, Asai S, Hirano Y, Kanayama Y, Yabe Y, Oguchi T, Fujibayashi T, Ishikawa H, Hanabayashi M, Hattori Y, Suzuki M, Kishimoto K, Ohashi Y, Imaizumi T, Imagama S, Kojima T
Modern rheumatology 2022年3月
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Relationship between locomotive syndrome and frailty in rheumatoid arthritis patients by locomotive syndrome stage. 査読有り
Sobue Y, Suzuki M, Ohashi Y, Koshima H, Okui N, Funahashi K, Ishikawa H, Asai S, Terabe K, Yokota Y, Kishimoto K, Takahashi N, Imagama S, Kojima T
Modern rheumatology 2021年9月
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Depression, physical function, and disease activity associated with frailty in patients with rheumatoid arthritis 査読有り
Kojima Masayo, Kojima Toshihisa, Waguri-Nagaya Yuko, Takahashi Nobunori, Asai Shuji, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Mitsui Hiroto, Kawaguchi Yohei, Kuroyanagi Gen, Yasuoka Mikako, Watanabe Miki, Suzuki Sadao, Arai Hidenori
MODERN RHEUMATOLOGY 31 巻 ( 5 ) 頁： 979 - 986 2021年9月
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Impact of social support on severity of depressive symptoms by remission status in patients with rheumatoid arthritis. 査読有り
Yasuoka M, Kojima T, Waguri-Nagaya Y, Saito T, Takahashi N, Asai S, Sobue Y, Nishiume T, Suzuki M, Mitsui H, Kawaguchi Y, Kuroyanagi G, Kamiji K, Watanabe M, Suzuki S, Kondo K, Ojima T, Kojima M
Modern rheumatology 2021年8月
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Comparison of the effects of baricitinib and tocilizumab on disease activity in patients with rheumatoid arthritis: a propensity score matching analysis 査読有り
Asai Shuji, Takahashi Nobunori, Kobayakawa Tomonori, Kaneko Atsushi, Watanabe Tatsuo, Kato Takefumi, Nishiume Tsuyoshi, Ishikawa Hisato, Yoshioka Yutaka, Kanayama Yasuhide, Watanabe Tsuyoshi, Hirano Yuji, Hanabayashi Masahiro, Yabe Yuichiro, Yokota Yutaka, Suzuki Mochihito, Terabe Kenya, Ishiguro Naoki, Imagama Shiro, Kojima Toshihisa
CLINICAL RHEUMATOLOGY 40 巻 ( 8 ) 頁： 3143 - 3151 2021年8月
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Higher doses of methotrexate associated with discontinuation of oral glucocorticoids after initiation of biological DMARDs: A retrospective observational study based on data from a Japanese multicenter registry study 査読有り
Suzuki Mochihito, Kojima Toshihisa, Takahashi Nobunori, Asai Shuji, Terabe Kenya, Kaneko Atsushi, Hirano Yuji, Hanabayashi Masahiro, Oguchi Takeshi, Takagi Hideki, Kanayama Yasuhide, Yabe Yuichiro, Funahashi Koji, Fujibayashi Takayoshi, Tsuboi Seiji, Ito Takayasu, Yoshioka Yutaka, Ishikawa Hisato, Sobue Yasumori, Nishiume Tsuyoshi, Yokota Yutaka, Ishiguro Naoki
MODERN RHEUMATOLOGY 31 巻 ( 4 ) 頁： 796 - 802 2021年7月
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REASONS AND RISK FACTOR FOR DISCONTINUATION OF BIOLOGIC AGENTS FOR RHEUMATOID ARTHRITIS PATIENTS IN LONG-TERM OBSERVATION 査読有り
Terabe K., Takahashi N., Asai S., Hirano Y., Kanayama Y., Kojima T.
ANNALS OF THE RHEUMATIC DISEASES 80 巻 頁： 1142 - 1143 2021年6月
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Fifteen-year trends in the number and age of patients with rheumatoid arthritis undergoing total knee and hip arthroplasty: A comparison study with osteoarthritis 査読有り
Asai Shuji, Takemoto Toki, Takahashi Nobunori, Oguchi Takeshi, Ishiguro Naoki, Kojima Toshihisa
MODERN RHEUMATOLOGY 31 巻 ( 3 ) 頁： 768 - 771 2021年5月
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Relationship between the physician-based clinical scale for foot and ankle surgery and patient-reported outcomes in patients with long-standing rheumatoid arthritis: Results from a multicenter prospective observational cohort study 査読有り
Kojima Toshihisa, Ishikawa Hajime, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Kojima Masayo, Ishiguro Naoki
MODERN RHEUMATOLOGY 31 巻 ( 3 ) 頁： 607 - 613 2021年5月
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Relationship between disease activity of rheumatoid arthritis and development of locomotive syndrome: A five-year longitudinal cohort study 査読有り
Sobue Yasumori, Kojima Toshihisa, Funahashi Koji, Okui Nobuyuki, Takahashi Nobunori, Asai Shuji, Terabe Kenya, Nishiume Tsuyoshi, Suzuki Mochihito, Yokota Yutaka, Ohashi Yoshifumi, Ishiguro Naoki
MODERN RHEUMATOLOGY 31 巻 ( 1 ) 頁： 101 - 107 2021年1月
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Predictors for clinical effectiveness of baricitinib in rheumatoid arthritis patients in routine clinical practice: data from a Japanese multicenter registry 査読有り
Takahashi Nobunori, Asai Shuji, Kobayakawa Tomonori, Kaneko Atsushi, Watanabe Tatsuo, Kato Takefumi, Nishiume Tsuyoshi, Ishikawa Hisato, Yoshioka Yutaka, Kanayama Yasuhide, Watanabe Tsuyoshi, Hirano Yuji, Hanabayashi Masahiro, Yabe Yuichiro, Yokota Yutaka, Suzuki Mochihito, Sobue Yasumori, Terabe Kenya, Ishiguro Naoki, Kojima Toshihisa
SCIENTIFIC REPORTS 10 巻 ( 1 ) 頁： 21907 2020年12月
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Predictors of disease flare after discontinuation of concomitant methotrexate in Japanese patients with rheumatoid arthritis treated with tocilizumab 査読有り
Asai Shuji, Takahashi Nobunori, Hayashi Masatoshi, Hanabayashi Masahiro, Kanayama Yasuhide, Takemoto Toki, Yabe Yuichiro, Shioura Tomone, Ishikawa Hisato, Yoshioka Yutaka, Kato Takefumi, Hirano Yuji, Fujibayashi Takayoshi, Hattori Yosuke, Kobayakawa Tomonori, Ando Masahiko, Kuwatsuka Yachiyo, Matsumoto Takuya, Asai Nobuyuki, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki, Kojima Toshihisa
JOINT BONE SPINE 87 巻 ( 6 ) 頁： 596 - 602 2020年12月
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A retrospective analysis of the relationship between anti-cyclic citrullinated peptide antibody and the effectiveness of abatacept in rheumatoid arthritis patients 査読有り
Kida Daihei, Takahashi Nobunori, Kaneko Atsushi, Hirano Yuji, Fujibayashi Takayoshi, Kanayama Yasuhide, Hanabayashi Masahiro, Yabe Yuichiro, Takagi Hideki, Oguchi Takeshi, Kato Takefumi, Funahashi Koji, Matsumoto Takuya, Ando Masahiko, Kuwatsuka Yachiyo, Tanaka Eiichi, Yasuoka Hidekata, Kaneko Yuko, Hirata Shintaro, Murakami Kosaku, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Yokota Yutaka, Terabe Kenya, Asai Shuji, Ishiguro Naoki, Kojima Toshihisa
SCIENTIFIC REPORTS 10 巻 ( 1 ) 頁： 19717 2020年11月
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Periarticular osteophyte formation protects against total knee arthroplasty in rheumatoid arthritis patients with advanced joint damage 査読有り
Asai Shuji, Takahashi Nobunori, Terabe Kenya, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Yokota Yutaka, Ishiguro Naoki, Kojima Toshihisa
CLINICAL RHEUMATOLOGY 39 巻 ( 11 ) 頁： 3331 - 3339 2020年11月
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Factors associated with osteophyte formation in patients with rheumatoid arthritis undergoing total knee arthroplasty 査読有り
Asai Nobuyuki, Asai Shuji, Takahashi Nobunori, Ishiguro Naoki, Kojima Toshihisa
MODERN RHEUMATOLOGY 30 巻 ( 5 ) 頁： 937 - 939 2020年9月
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Improvement in matrix metalloproteinase-3 independently predicts low disease activity at 52 weeks in bio-switch rheumatoid arthritis patients treated with abatacept. 査読有り
Takemoto T, Takahashi N, Kida D, Kaneko A, Hirano Y, Fujibayashi T, Kanayama Y, Hanabayashi M, Yabe Y, Takagi H, Oguchi T, Kato T, Funahashi K, Matsumoto T, Sobue Y, Nishiume T, Suzuki M, Yokota Y, Terabe K, Asai S, Ishiguro N, Kojima T
Clinical and experimental rheumatology 38 巻 ( 5 ) 頁： 933 - 939 2020年9月
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Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: A 14-year trend analysis (2004-2017) 査読有り
Asai Shuji, Takahashi Nobunori, Asai Nobuyuki, Yamashita Satoshi, Terabe Kenya, Matsumoto Takuya, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki, Kojima Toshihisa
MODERN RHEUMATOLOGY 30 巻 ( 4 ) 頁： 657 - 663 2020年7月
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COMPARATIVE STUDY OF PATIENT BACKGROUND AND TREATMENT OUTCOME BY BARICITINIB DOSE UNDER REAL CLINICAL CONDITIONS. 査読有り
Nishiume T., Takahashi N., Kojima T., Asai S., Terabe K., Ishiguro N.
ANNALS OF THE RHEUMATIC DISEASES 79 巻 頁： 1472 - 1473 2020年6月
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THE EFFECTIVENESS OF BIOLOGICAL AGENTS CONCOMITANT WITH TACROLIMUS IN RHEUMATOID ARTHRITIS 査読有り
Terabe K., Takahashi N., Asai S., Kaneko A., Hirano Y., Kanayama Y., Yabe Y., Kojima T., Ishiguro N.
ANNALS OF THE RHEUMATIC DISEASES 79 巻 頁： 304 - 305 2020年6月
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PREDICTORS OF DISEASE FLARE AFTER DISCONTINUATION OF CONCOMITANT METHOTREXATE IN JAPANESE PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH TOCILIZUMAB 査読有り
Asai S., Takahashi N., Kuwatsuka Y., Ando M., Ishiguro N., Kojima T.
ANNALS OF THE RHEUMATIC DISEASES 79 巻 頁： 252 - 253 2020年6月
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PREDICTORS FOR SHORT-TERM CLINICAL EFFECTIVENESS OF BARICITINIB IN RHEUMATOID ARTHRITIS PATIENTS IN ROUTINE CLINICAL PRACTICE: DATA FROM A JAPANESE MULTICENTER REGISTRY 査読有り
Takahashi N., Kojima T., Asai S., Terabe K., Ishiguro N.
ANNALS OF THE RHEUMATIC DISEASES 79 巻 頁： 646 - 646 2020年6月
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PERIARTICULAR OSTEOPHYTE FORMATION PROTECTS AGAINST TOTAL KNEE ARTHROPLASTY IN RHEUMATOID ARTHRITIS PATIENTS WITH ADVANCED JOINT DAMAGE 査読有り
Asai S., Takahashi N., Terabe K., Kojima T., Ishiguro N.
ANNALS OF THE RHEUMATIC DISEASES 79 巻 頁： 1384 - 1385 2020年6月
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IMPROVEMENT OF DEPRESSION BY JOINT SURGERY IN ESTABLISHED RHEUMATOID ARTHRITIS; RESULTS FROM MULTICENTER PROSPECTIVE COHORT STUDY FOR EVALUATION OF JOINT SURGERY ON PATIENT'S REPORTED OUTCOME 査読有り
Kojima T., Kojima M., Ishikawa H., Nishida K., Asai S., Ishiguro N.
ANNALS OF THE RHEUMATIC DISEASES 79 巻 頁： 1872 - 1873 2020年6月
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HIGHER DOSES OF METHOTREXATE ASSOCIATED WITH DISCONTINUATION OF ORAL GLUCOCORTICOIDS AFTER INITIATION OF BIOLOGICAL DMARDS: A RETROSPECTIVE OBSERVATIONAL STUDY BASED ON DATA FROM A JAPANESE MULTICENTER REGISTRY STUDY 査読有り
Suzuki M., Kojima T., Takahashi N., Asai S., Terabe K., Ishiguro N.
ANNALS OF THE RHEUMATIC DISEASES 79 巻 頁： 991 - 992 2020年6月
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EFFECTIVENESS OF ABATACEPT ON CLINICAL DISEASE ACTIVITY AND RADIOGRAPHIC PROGRESSION IN RHEUMATOID ARTHRITIS PATIENTS IN DAILY CLINICAL PRACTICE IN JAPAN: COMPARISONS ACCORDING TO ACPA STATUS 査読有り
Takahashi N., Kojima T., Asai S., Terabe K., Ishiguro N.
ANNALS OF THE RHEUMATIC DISEASES 79 巻 頁： 629 - 630 2020年6月
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Discontinuation of concomitant methotrexate in Japanese patients with rheumatoid arthritis treated with tocilizumab: An interventional study 査読有り
Asai Shuji, Hayashi Masatoshi, Hanabayashi Masahiro, Kanayama Yasuhide, Takemoto Toki, Yabe Yuichiro, Shioura Tomone, Ishikawa Hisato, Yoshioka Yutaka, Kato Takefumi, Hirano Yuji, Fujibayashi Takayoshi, Hattori Yosuke, Kobayakawa Tomonori, Ando Masahiko, Kuwatsuka Yachiyo, Takahashi Nobunori, Matsumoto Takuya, Asai Nobuyuki, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki, Kojima Toshihisa
MODERN RHEUMATOLOGY 30 巻 ( 3 ) 頁： 434 - 441 2020年5月
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Targetable driver mutations in multicentric reticulohistiocytosis 査読有り
Murakami Norihiro, Sakai Tomohisa, Arai Eisuke, Muramatsu Hideki, Ichikawa Daisuke, Asai Shuji, Shimoyama Yoshie, Ishiguro Naoki, Takahashi Yoshiyuki, Okuno Yusuke, Nishida Yoshihiro
HAEMATOLOGICA 105 巻 ( 2 ) 頁： E61 - E64 2020年1月
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Improvement in matrix metalloproteinase-3 independently predicts low disease activity at 52 weeks in bio-switch rheumatoid arthritis patients treated with abatacept 査読有り
Takemoto T., Takahashi N., Kida D., Kaneko A., Hirano Y., Fujibayashi T., Kanayama Y., Hanabayashi M., Yabe Y., Takagi H., Oguchi T., Kato T., Funahashi K., Matsumoto T., Sobue Y., Nishiume T., Suzuki M., Yokota Y., Terabe K., Asai S., Ishiguro N., Kojima T.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 38 巻 ( 5 ) 頁： 933 - 939 2020年
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Clinical effectiveness and safety of additional administration of tacrolimus in rheumatoid arthritis patients with an inadequate response to abatacept: A retrospective cohort study 査読有り
Suzuki Mochihito, Takahashi Nobunori, Kida Daihei, Hirano Yuji, Kato Takefumi, Yabe Yuichiro, Oguchi Takeshi, Fujibayashi Takayoshi, Hayashi Masatoshi, Asai Shuji, Ishiguro Naoki, Kojima Toshihisa
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 22 巻 ( 12 ) 頁： 2199 - 2205 2019年12月
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Clinical effectiveness and long-term retention of abatacept in elderly rheumatoid arthritis patients: Results from a multicenter registry system 査読有り
Takahashi Nobunori, Kojima Toshihisa, Kida Daihei, Kaneko Atsushi, Hirano Yuji, Fujibayashi Takayoshi, Yabe Yuichiro, Takagi Hideki, Oguchi Takeshi, Hanabayashi Masahiro, Kato Takefumi, Funahashi Koji, Hayashi Masatoshi, Tsuboi Seiji, Kanayama Yasuhide, Sobue Yasumori, Asai Nobuyuki, Matsumoto Takuya, Watanabe Tatsuo, Asai Shuji, Ishiguro Naoki
MODERN RHEUMATOLOGY 29 巻 ( 6 ) 頁： 910 - 918 2019年11月
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Association between seropositivity and discontinuation of tumor necrosis factor inhibitors due to ineffectiveness in rheumatoid arthritis 査読有り
Ogawa Yoshikazu, Takahashi Nobunori, Kaneko Atsushi, Hirano Yuji, Kanayama Yasuhide, Yabe Yuichiro, Oguchi Takeshi, Fujibayashi Takayoshi, Takagi Hideki, Hanabayashi Masahiro, Funahashi Koji, Hayashi Masatoshi, Tsuboi Seiji, Asai Shuji, Asai Nobuyuki, Matsumoto Takuya, Sobue Yasumori, Ishiguro Naoki, Kojima Toshihisa
CLINICAL RHEUMATOLOGY 38 巻 ( 10 ) 頁： 2757 - 2763 2019年10月
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Improving Depression by Joint Surgery in Established Rheumatoid Arthritis; Results from Multicenter Prospective Cohort Study for Evaluation of Joint Surgery on Patient's Reported Outcome 査読有り
Kojima Toshihisa, Kojima Masayo, Ishikawa Hajime, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Ishiguro Naoki
ARTHRITIS & RHEUMATOLOGY 71 巻 2019年10月
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Improvement in Matrix metalloproteinase-3 Levels at 12 Weeks Independently Predicts Achievement of Low Disease Activity at 52 Weeks in Bio-switch Patients with Rheumatoid Arthritis Treated with Abatacept 査読有り
Takahashi Nobunori, Kojima Toshihisa, Terabe Kenya, Asai Shuji, Ishiguro Naoki
ARTHRITIS & RHEUMATOLOGY 71 巻 2019年10月
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Discontinuation of Oral Glucocorticoid After Initiation of Biological DMARDs Due to a Higher Dose of Methotrexate; A Retrospective Observational Study Based on Data from a Japanese Multicenter Registry Study 査読有り
Suzuki Mochihito, Kojima Toshihisa, Takahashi Nobunori, Asai Shuji, Ishiguro Naoki
ARTHRITIS & RHEUMATOLOGY 71 巻 2019年10月
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Discontinuation of Concomitant Methotrexate in Japanese Patients with Rheumatoid Arthritis Treated with Tocilizumab: An Interventional Study 査読有り
Kojima Toshihisa, Asai Shuji, Hanabayashi Masahiro, Hayashi Masatoshi, Takahashi Nobunori, Kuwatsuka Yachiyo, Ando Masahiko, Ishiguro Naoki
ARTHRITIS & RHEUMATOLOGY 71 巻 2019年10月
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Characteristics of Patients with Rheumatoid Arthritis Undergoing Primary Total Joint Replacement: A 14-year Trend Analysis (2004-2017) 査読有り
Asai Shuji, Kojima Toshihisa, Takahashi Nobunori, Ishiguro Naoki
ARTHRITIS & RHEUMATOLOGY 71 巻 2019年10月
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Concomitant methotrexate has little effect on clinical outcomes of abatacept in rheumatoid arthritis: a propensity score matching analysis 査読有り
Takahashi Nobunori, Kojima Toshihisa, Kida Daihei, Kaneko Atsushi, Hirano Yuji, Fujibayashi Takayoshi, Yabe Yuichiro, Takagi Hideki, Oguchi Takeshi, Hanabayashi Masahiro, Kato Takefumi, Funahashi Koji, Hayashi Masatoshi, Tsuboi Seiji, Kanayama Yasuhide, Sobue Yasumori, Asai Nobuyuki, Matsumoto Takuya, Watanabe Tatsuo, Asai Shuji, Ishiguro Naoki
CLINICAL RHEUMATOLOGY 38 巻 ( 9 ) 頁： 2451 - 2459 2019年9月
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Relationship between rheumatoid arthritis and locomotive syndrome: validation of the 25-question Geriatric Locomotive Function Scale in patients with rheumatoid arthritis 査読有り
Sobue Yasumori, Kojima Toshihisa, Funahashi Koji, Okui Nobuyuki, Mizuno Masanori, Takahashi Nobunori, Asai Shuji, Asai Nobuyuki, Matsumoto Takuya, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki
NAGOYA JOURNAL OF MEDICAL SCIENCE 81 巻 ( 3 ) 頁： 453 - 462 2019年8月
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DEPRESSION IN ESTABLISHED RHEUMATOID ARTHRITIS; MULTICENTER PROSPECTIVE COHORT STUDY FOR EVALUATION OF JOINT SURGERY ON PATIENT'S REPORTED OUTCOME 査読有り
Kojima Toshihisa, Kojima Masayo, Ishikawa Hajime, Tanaka Sakae, Nishida Keiichiro, Haga Nobuhiko, Masaoka Yukio, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Ishiguro Naoki
ANNALS OF THE RHEUMATIC DISEASES 78 巻 頁： 2124 - 2125 2019年6月
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IMPROVEMENT OF MATRIX METALLOPROTEINASE-3 AT 12 WEEKS IS AN INDEPENDENT PREDICTIVE FACTOR FOR ACHIEVEMENT OF LOW DISEASE ACTIVITY AT 52 WEEKS IN BIO-SWITCH RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ABATACEPT 査読有り
Takahashi Nobunori, Kojima Toshihisa, Asai Shuji, Ishiguro Naoki
ANNALS OF THE RHEUMATIC DISEASES 78 巻 頁： 728 - 729 2019年6月
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DISCONTINUATION OF CONCOMITANT METHOTREXATE IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH TOCILIZUMAB: AN INTERVENTIONAL STUDY 査読有り
Asai Shuji, Kojima Toshihisa, Takahashi Nobunori, Kuwatsuka Yachiyo, Ando Masahiko, Ishiguro Naoki
ANNALS OF THE RHEUMATIC DISEASES 78 巻 頁： 1641 - 1641 2019年6月
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Association between chest computed tomography findings and respiratory adverse events in rheumatoid arthritis patients undergoing long-term biological therapy 査読有り
Matsumoto Takuya, Iwano Shingo, Takahashi Nobunori, Asai Shuji, Watanabe Tatsuo, Asai Nobuyuki, Sobue Yasumori, Ito Satoru, Ishiguro Naoki, Kojima Toshihisa
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 22 巻 ( 4 ) 頁： 626 - 635 2019年4月
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Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis 査読有り
Asai Shuji, Nagai Kaoru, Takahashi Nobunori, Watanabe Tatsuo, Matsumoto Takuya, Asai Nobuyuki, Sobue Yasumori, Ishiguro Naoki, Kojima Toshihisa
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 22 巻 ( 2 ) 頁： 207 - 213 2019年2月
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Computed tomography evaluation of the periacetabular gap of a porous tantalum acetabular component 査読有り
Asai Shuji, Sobue Yasumori, Asai Nobuyuki, Takahashi Nobunori, Watanabe Tatsuo, Matsumoto Takuya, Ishiguro Naoki, Kojima Toshihisa
NAGOYA JOURNAL OF MEDICAL SCIENCE 81 巻 ( 1 ) 頁： 159 - 163 2019年2月
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Validation and reliability of the Timed Up and Go test for measuring objective functional impairment in patients with long-standing rheumatoid arthritis: a cross-sectional study 査読有り
Kojima Toshihisa, Ishikawa Hajime, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Kojima Masayo, Ishiguro Naoki
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 21 巻 ( 10 ) 頁： 1793 - 1800 2018年10月
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Target setting for lower limb joint surgery using the Timed Up and Go test in patients with rheumatoid arthritis: A prospective cohort study 査読有り
Kojima Toshihisa, Ishikawa Hajime, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Kojima Masayo, Ishiguro Naoki
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 21 巻 ( 10 ) 頁： 1801 - 1808 2018年10月
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Setting Treatment Target for Joint Surgery in Lower Limbs in Patients with Long-Standing Rheumatoid Arthritis Based on Multicenter Prospective Cohort Study; Validation and Reliability of Objective Index of Activity Speed (Timed Up and Go test) for Measuring Physical Function 査読有り
Kojima Toshihisa, Ishikawa Hajime, Kojima Masayo, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Ishiguro Naoki
ARTHRITIS & RHEUMATOLOGY 70 巻 頁： . 2018年9月
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PREDICTIVE FACTORS FOR ACHIEVEMENT OF LOW DISEASE ACTIVITY AT 52 WEEKS ARE DIFFERENT BETWEEN YOUNG AND ELDERLY RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ABATACEPT 査読有り
Takahashi N., Kojima T., Asai S., Ishiguro N.
ANNALS OF THE RHEUMATIC DISEASES 77 巻 頁： 326-327 2018年6月
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INFLUENCE OF ORAL PREDNISOLONE ON EFFECT OF DENOSUMAB ON OSTEOPOROSIS IN PATIENTS WITH JAPANESE RHEUMATOID ARTHRITIS; 36 MONTHS OF FOLLOW-UP similar to A MULTICENTER REGISTRY STUDY similar to 査読有り
Kanayama Y., Hirano Y., Takahashi N., Asai S., Ishiguro N., Kojima T.
ANNALS OF THE RHEUMATIC DISEASES 77 巻 頁： 458-459 2018年6月
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THE EFFECT OF METHOTREXATE ON GASTROINTESTINAL SYMPTOMS IN PATIENTS WITH RHEUMATOID ARTHRITIS 査読有り
Asai S., Nagai K., Kojima T., Takahashi N., Ishiguro N.
ANNALS OF THE RHEUMATIC DISEASES 77 巻 頁： 306-307 2018年6月
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SETTING TREATMENT TARGET FOR JOINT SURGERY IN LOWER LIMBS IN PATIENTS WITH LONG-STANDING RHEUMATOID ARTHRITIS BASED ON MULTICENTER PROSPECTIVE COHORT STUDY; VALIDATION AND RELIABILITY OF OBJECTIVE INDEX OF ACTIVITY SPEED, TIMED UP AND GO TEST, FOR MEASURING PHYSICAL FUNCTION 査読有り
Kojima T., Ishikawa H., Tanaka S., Haga N., Nishida K., Yukioka M., Hashimoto J., Miyahara H., Niki Y., Kimura T., Oda H., Funahashi K., Asai S., Kojima M., Ishiguro N.
ANNALS OF THE RHEUMATIC DISEASES 77 巻 頁： 1333-1334 2018年6月
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Multicentric reticulohistiocytosis misdiagnosed as tenosynovial giant cell tumour 査読有り
Nishida Yoshihiro, Asai Shuji, Arai Eisuke
RHEUMATOLOGY 57 巻 ( 3 ) 頁： 461 - 461 2018年3月
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Characteristics of functional impairment in patients with long-standing rheumatoid arthritis based on range of motion of joints: Baseline data from a multicenter prospective observational cohort study to evaluate the effectiveness of joint surgery in the treat-to-target era 査読有り
Kojima Toshihisa, Ishikawa Hajime, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Kojima Masayo, Ishiguro Naoki
MODERN RHEUMATOLOGY 28 巻 ( 3 ) 頁： 474 - 481 2018年
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Predictors of biologic discontinuation due to insufficient response in patients with rheumatoid arthritis who achieved clinical remission with biologic treatment: A multicenter observational cohort study 査読有り
Asai Shuji, Fujibayashi Takayoshi, Oguchi Takeshi, Hanabayashi Masahiro, Hayashi Masatoshi, Matsubara Hiroyuki, Ito Takayasu, Yabe Yuichiro, Watanabe Tsuyoshi, Hirano Yuji, Kanayama Yasuhide, Kaneko Atsushi, Kato Takefumi, Takagi Hideki, Takahashi Nobunori, Funahashi Koji, Takemoto Toki, Asai Nobuyuki, Watanabe Tatsuo, Ishiguro Naoki, Kojima Toshihisa
MODERN RHEUMATOLOGY 28 巻 ( 2 ) 頁： 221 - 226 2018年
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Influence of glucocorticoids on effect of denosumab on osteoporosis in patients with Japanese rheumatoid arthritis; 24 months of follow-up similar to a Multicenter Registry Study similar to. 査読有り
Kanayama Yasuhide, Hirano Yuji, Takahashi Nobunori, Asai Shuji, Ishiguro Naoki, Kojima Toshihisa
JOURNAL OF BONE AND MINERAL RESEARCH 32 巻 頁： S379-S380 2017年12月
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Being Elderly Is Not a Predictive Factor of Discontinuation of Abatacept Due to Adverse Events in Rheumatoid Arthritis Patients with Concomitant Methotrexate: A Retrospective Observational Study Based on Data from a Japanese Multicenter Registry Study 査読有り
Takahashi Nobunori, Kojima Toshihisa, Asai Shuji, Watanabe Tatsuo, Matsumoto Takuya, Asai Nobuyuki, Sobue Yasumori, Ishiguro Naoki
ARTHRITIS & RHEUMATOLOGY 69 巻 頁： . 2017年10月
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Patient-reported outcomes as assessment tools and predictors of long-term prognosis: a 7-year follow-up study of patients with rheumatoid arthritis 査読有り
Kojima Masayo, Kojima Toshihisa, Suzuki Sadao, Takahashi Nobunori, Funahashi Koji, Asai Shuji, Yoshioka Yutaka, Terabe Kenya, Asai Nobuyuki, Takemoto Toki, Ishiguro Naoki
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 20 巻 ( 9 ) 頁： 1193-1200 2017年9月
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TENDENCY TO CHOOSE FIRST BIOLOGIC AGENT THERAPY OF RHEUMATOID ARTHRITIS IN THE ELDERLY: RESULTS FROM JAPANESE MULTICENTER REGISTRY 査読有り
Watanabe T., Kojima T., Takahashi N., Asai S., Asai N., Matsumoto T., Sobue Y., Ishiguro N.
ANNALS OF THE RHEUMATIC DISEASES 76 巻 頁： 1195-1195 2017年6月
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INFLUENCE OF ORAL PREDNISOLONE ON EFFECT OF DENOSUMAB ON OSTEOPOROSIS IN PATIENTS WITH JAPANESE RHEUMATOID ARTHRITIS; 24 MONTHS OF FOLLOW-UP similar to A MULTICENTER REGISTRY STUDY similar to 査読有り
Kanayama Y., Hirano Y., Takahashi N., Asai S., Ishiguro N., Kojima T.
ANNALS OF THE RHEUMATIC DISEASES 76 巻 頁： 708-708 2017年6月
科研費 2
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代謝リプログラミングによる腱由来間葉系幹細胞の分化制御の解明
研究課題/研究課題番号：21K09274 2021年4月 - 2024年3月
科学研究費助成事業 基盤研究(C)
浅井 秀司, 寺部 健哉
担当区分：研究代表者
配分額：4030000円 （ 直接経費：3100000円 、 間接経費：930000円 ）
腱損傷部には変性と修復の両方に直接関与する特異的な間葉系幹細胞が誘導される。本研究では、この間葉系幹細胞の分化における解糖系代謝を中心とした代謝リプログラミングの機能解析を行う。また、腱損傷部の変性および修復に対する代謝リプログラミング制御の作用を明らかにする。これにより、内在性の間葉系幹細胞の分化を制御し、細胞移植を必要としない腱損傷の新たな治療法の開発につなげる。
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ヒアルロン酸による腱由来間葉系幹細胞の分化制御の解明と腱変性予防への応用
研究課題/研究課題番号：18K16618 2018年4月 - 2022年3月
科学研究費助成事業 若手研究
浅井 秀司
担当区分：研究代表者
配分額：4160000円 （ 直接経費：3200000円 、 間接経費：960000円 ）
腱は修復能に乏しく損傷すると元の状態まで回復することは困難であり, 加齢とともに軟骨化生や異所性骨化などの変性を生じやすくなる. 過去の研究結果をもとに, 本研究では 「ヒアルロン酸は腱損傷部に誘導される間葉系幹細胞においてヒアルロン酸レセプターCD44を介してMAPKのリン酸化を抑制し, 腱損傷後の軟骨化生を抑制するとともに腱の修復を促進する」 という仮説を立てた. 損傷腱に対するヒアルロン酸の変性予防効果と細胞内情報伝達機構を検討し以下の結果を得た．
① CD-1マウスのアキレス腱損傷部から単離した損傷腱由来間葉系幹細胞をmicro mass cultureにより軟骨細胞へ分化誘導し, ヒアルロン酸で処理した. アルシアンブルー染色のintegrated densityはヒアルロン酸の濃度に依存して減少した. また, 軟骨分化マーカーであるaggrecan, Sox9, II型コラーゲンの遺伝子発現量はヒアルロン酸の濃度に依存して減少した. 一方で腱分化マーカーであるMohawk, I型コラーゲンの遺伝子発現量はヒアルロン酸の濃度に依存して増加した. これらのヒアルロン酸の作用は抗CD44抗体により減弱せず, 抗CD44抗体単独でも軟骨分化マーカーの遺伝子発現量は減少した.
② ヒアルロン酸合成阻害剤4-メチルウンベリフェロン (4-MU) を用いて同様の実験を行った. その結果, aggrecanの遺伝子発現量はヒアルロン酸の濃度に依存して増加したが, Mohawkの遺伝子発現量に有意な変化は認められなかった. この結果は, 損傷腱由来間葉系幹細胞におけるヒアルロン酸の軟骨分化抑制作用を裏付けるものである.
③ In vivo実験として, アキレス腱損傷モデルマウスにヒアルロン酸の局所投与および4-MUの腹腔内投与を行っている.
本研究では, アキレス腱損傷モデルマウスおよびそのマウスから単離した初代培養細胞を用いて実験を行っている.
理由① 新型コロナウイルス感染拡大の影響により実験動物舎が一時使用不能となったため.
理由② in vivoにおいて, ヒアルロン酸の粘稠度が高くマウスのアキレス腱損傷部にヒアルロン酸を局所投与する手技の確立に時間を要したため.
2020年度までの研究により, ヒアルロン酸が損傷腱由来間葉系幹細胞の軟骨分化を抑制することが示された. さらに, CD44自体が損傷腱由来間葉系幹細胞の軟骨分化に重要な役割を果たしている可能性が示唆された. 今後は以下の実験を計画している.
① 現在in vivo実験で薬剤を投与しているモデルマウスの組織学的及び放射線学的評価
② MAPK経路を含めた損傷腱由来間葉系幹細胞におけるヒアルロン酸の細胞内情報伝達機構の検討