2026/04/01 更新

写真a

アサイ シュウジ
浅井 秀司
ASAI Shuji
所属
大学院医学系研究科 総合医学専攻 運動・形態外科学 准教授
大学院担当
大学院医学系研究科
学部担当
医学部 医学科
職名
准教授

学位 1

  1. 博士(医学) ( 2013年5月   名古屋大学 ) 

研究分野 1

  1. ライフサイエンス / 整形外科学

学歴 2

  1. 名古屋大学   医学系研究科

    - 2013年5月

      詳細を見る

    国名: 日本国

  2. 名古屋大学   医学部

    - 2002年3月

      詳細を見る

    国名: 日本国

所属学協会 2

  1. 日本リウマチ学会

  2. 日本整形外科学会

 

論文 138

  1. Evaluation of physical function in rheumatoid arthritis patients by locomotive syndrome stage 査読有り

    Yamamoto, H; Suzuki, M; Kojima, T; Sugiura, T; Saito, Y; Saito, Y; Terabe, K; Ohashi, Y; Sato, R; Hasegawa, J; Ohno, Y; Nagai, K; Ohnishi, C; Sugiura, H; Fujita, H; Nagayoshi, M; Kojima, M; Asai, S; Imagama, S

    MODERN RHEUMATOLOGY   36 巻 ( 2 ) 頁: 205 - 210   2026年3月

  2. Nutritional status and frailty in rheumatoid arthritis: A multicenter observational study (T-FLAG) 査読有り

    Suzuki, M; Asai, S; Ohashi, Y; Sobue, Y; Terabe, K; Imagama, S

    ARCHIVES OF GERONTOLOGY AND GERIATRICS   141 巻   2026年2月

  3. Effects of concomitant methotrexate and predictors of remission in Janus kinase inhibitor therapy for rheumatoid arthritis 査読有り

    Asai, S; Terabe, K; Hasegawa, J; Yoshioka, Y; Kato, T; Kojima, T; Ohno, Y; Kobayakawa, T; Watanabe, T; Sobue, Y; Nishiume, T; Kato, M; Fujibayashi, T; Hirano, Y; Kanayama, Y; Takemoto, T; Watanabe, T; Hanabayashi, M; Matsubara, H; Suzuki, M; Sato, R; Sugiura, T; Takahashi, N; Imagama, S

    JOINT BONE SPINE   93 巻 ( 1 )   2026年1月

  4. The impact of social frailty and physical function on laughter frequency in rheumatoid arthritis patients: data from a multicenter observational study (Tsurumai-frailty and locomotive syndrome of rheumatoid arthritis for globalization) 査読有り Open Access

    Suzuki, M; Asai, S; Ohashi, Y; Sobue, Y; Terabe, K; Sato, R; Hasegawa, J; Ohno, Y; Sugiura, T; Imagama, S

    MODERN RHEUMATOLOGY   36 巻 ( 1 ) 頁: 25 - 31   2026年1月

  5. Risk of Pneumocystis Pneumonia in Patients With Rheumatoid Arthritis and the Role of Prophylactic Salazosulfapyridine 査読有り Open Access

    Sato, R; Terabe, K; Imaizumi, T; Sakamoto, K; Sato, K; Hasegawa, J; Sugiura, T; Ono, Y; Suzuki, M; Asai, S; Imagama, S

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   28 巻 ( 12 )   2025年12月

  6. Grip strength asymmetry as a better indicator of residual hand symptoms than absolute grip strength after achieving treat-to-target in rheumatoid arthritis 査読有り

    Ohashi, Y; Suzuki, M; Sobue, Y; Terabe, K; Asai, S; Imagama, S; Takahashi, N

    MODERN RHEUMATOLOGY     2025年12月

  7. Features of sarcopenic obesity in rheumatoid arthritis patients 査読有り

    Saito, Y; Suzuki, M; Kojima, T; Yamamoto, H; Saito, Y; Terabe, K; Ohashi, Y; Sato, R; Hasegawa, J; Ohno, Y; Nagai, K; Ohnishi, C; Sugiura, H; Fujita, H; Nagayoshi, M; Kojima, M; Asai, S; Imagama, S

    GERIATRICS & GERONTOLOGY INTERNATIONAL   25 巻 ( 10 ) 頁: 1323 - 1331   2025年10月

  8. A randomized controlled trial comparing romosozumab and denosumab in elderly women with primary osteoporosis and knee osteoarthritis 査読有り Open Access

    Sobue, Y; Kosugiyama, H; Asai, S; Ogawa, Y; Yoneda, M; Maruyama, K; Kaneko, M; Kobayakawa, T; Terabe, K; Suzuki, M; Sato, R; Ohno, Y; Hasegawa, J; Sugiura, T; Ando, M; Kuwatsuka, Y; Ishiguro, N; Imagama, S

    SCIENTIFIC REPORTS   15 巻 ( 1 )   2025年7月

  9. Evaluation of Vertebrae in Patients With Ankylosing Spondylitis Using Hounsfield Unit Values 査読有り

    Hasegawa, J; Suzuki, M; Kishimoto, K; Sato, R; Ohno, Y; Sugiura, T; Yamamoto, H; Terabe, K; Asai, S; Imagama, S

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   28 巻 ( 7 )   2025年7月

  10. Association of spinal ankylosis with spinal mobility and functional impairment in radiographic axial spondyloarthritis: A computed tomography study 査読有り

    Kishimoto, K; Asai, S; Suzuki, M; Sato, R; Hasegawa, J; Ohno, Y; Terabe, K; Imagama, S

    MODERN RHEUMATOLOGY   35 巻 ( 4 ) 頁: 744 - 752   2025年7月

  11. IMPACT OF DISEASE ACTIVITY ON LONGITUDINAL CHANGES IN BODY COMPOSITION AND PHYSICAL FUNCTION IN RHEUMATOID ARTHRITIS PATIENTS 査読有り

    Saito, Y; Suzuki, M; Sugiura, T; Yamamoto, H; Sato, R; Ohno, Y; Hasegawa, J; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   84 巻   2025年6月

  12. EVALUATION OF THE UTILITY OF PHASE ANGLE IN THE DIAGNOSIS OF RHEUMATOID SARCOPENIA 査読有り

    Saito, Y; Suzuki, M; Sugiura, T; Yamamoto, H; Saito, Y; Sato, R; Ohno, Y; Hasegawa, J; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   84 巻   頁: 1966 - 1967   2025年6月

  13. EVALUATION OF PHYSICAL FUNCTION IN RHEUMATOID ARTHRITIS PATIENTS BY MOBILITY DISABILITY STAGE 査読有り

    Yamamoto, H; Suzuki, M; Sugiura, T; Saito, Y; Terabe, K; Sato, R; Hasegawa, J; Ohno, Y; Sato, T; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   84 巻   2025年6月

  14. DO RHEUMATOID ARTHRITIS PATIENTS WITH SUPPRESSED DISEASE ACTIVITY HAVE THE SAME PHYSICAL FUNCTION AS HEALTHY PEOPLE 査読有り

    Sugiura, T; Suzuki, M; Yamamoto, H; Saito, Y; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   84 巻   2025年6月

  15. DISCONTINUATION VS. CONTINUATION OF CONCOMITANT METHOTREXATE IN PATIENTS WITH RHEUMATOID ARTHRITIS ON CERTOLIZUMAB PEGOL: RESULTS FROM A RANDOMIZED, CONTROLLED TRIAL 査読有り

    Asai, S; Kojima, T; Ishikawa, H; Miyake, N; Kodera, M; Hasegawa, H; Sobue, Y; Kanayama, Y; Shimada, H; Hirano, Y; Hidaka, T; Fujibayashi, T; Matsumoto, T; Kobayakawa, T; Yasuoka, H; Kato, T; Hanabayashi, M; Kaneko, Y; Tada, M; Murata, K; Misaki, K; Ando, M; Kuwatsuka, Y; Suzuki, M; Terabe, K; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   84 巻   2025年6月

  16. DECIPHERING FRAILTY PROGRESSION IN RHEUMATOID ARTHRITIS PATIENTS OVER FIVE YEARS: FINDINGS FROM THE T-FLAG MULTICENTER OBSERVATIONAL STUDY 査読有り

    Ohashi, Y; Suzuki, M; Sobue, Y; Terabe, K; Asai, S; Imagama, S; Takahashi, N

    ANNALS OF THE RHEUMATIC DISEASES   84 巻   頁: 1965 - 1966   2025年6月

  17. CONQUERING DIFFICULT-TO-TREAT RHEUMATOID ARTHRITIS: A POTENTIAL PATH TO RESOLVING RHEUMATIC SARCOPENIA 査読有り

    Ohashi, Y; Suzuki, M; Sobue, Y; Terabe, K; Asai, S; Imagama, S; Takahashi, N

    ANNALS OF THE RHEUMATIC DISEASES   84 巻   2025年6月

  18. CLINICAL AND FUNCTIONAL DISTINCTIONS BETWEEN LATE-ONSET AND YOUNG-ONSET RHEUMATOID ARTHRITIS IN OLDER FEMALE PATIENTS 査読有り

    Saito, Y; Suzuki, M; Sugiura, T; Yamamoto, H; Saito, Y; Sato, R; Ohno, Y; Hasegawa, J; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   84 巻   2025年6月

  19. ASSOCIATION BETWEEN NUTRITIONAL STATUS AND FRAILTY IN PATIENTS WITH RHEUMATOID ARTHRITIS FROM A MULTICENTER OBSERVATIONAL STUDY (T-FLAG STUDY) 査読有り

    Suzuki, M; Ohashi, Y; Sobue, Y; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   84 巻   2025年6月

  20. SARCOPENIA AND INFLAMMATION, NOT DISEASE ACTIVITY, AS DETERMINANTS OF NUTRITIONAL RISK IN RHEUMATOID ARTHRITIS PATIENTS 査読有り

    Sobue, Y; Suzuki, M; Ohashi, Y; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   84 巻   2025年6月

  21. THE IMPACT OF SOCIAL FRAILTY AND PHYSICAL FUNCTION ON LAUGHTER FREQUENCY IN RHEUMATOID ARTHRITIS PATIENTS FROM A MULTICENTER OBSERVATIONAL STUDY (T-FLAG) 査読有り

    Suzuki, M; Ohashi, Y; Sobue, Y; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   84 巻   2025年6月

  22. THE IMPACT OF SARCOPENIC OBESITY ON PHYSICAL FUNCTION AND QUALITY OF LIFE IN RHEUMATOID ARTHRITIS PATIENTS 査読有り

    Saito, Y; Suzuki, M; Sugiura, T; Yamamoto, H; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   84 巻   2025年6月

  23. Comparable Clinical Effectiveness of Baricitinib and Filgotinib in Patients With Rheumatoid Arthritis 査読有り Open Access

    Kosugiyama, H; Asai, S; Terabe, K; Kobayakawa, T; Yoshioka, Y; Watanabe, T; Kojima, T; Sobue, Y; Kato, T; Fujibayashi, T; Hirano, Y; Nishiume, T; Kato, M; Kanayama, Y; Takemoto, T; Hanabayashi, M; Matsubara, H; Suzuki, M; Sato, R; Hasegawa, J; Ohno, Y; Sugiura, T; Takahashi, N; Imagama, S

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   28 巻 ( 5 )   2025年5月

  24. Investigation of the Risk of Frailty Progression Based on 5-Year Data in Patients With Rheumatoid Arthritis: A Multicenter Observational Study (T-FLAG) 査読有り Open Access

    Ohashi, Y; Suzuki, M; Sobue, Y; Terabe, K; Asai, S; Imagama, S; Takahashi, N

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   28 巻 ( 4 )   2025年4月

  25. Discontinuation vs. continuation of concomitant methotrexate in patients with rheumatoid arthritis on certolizumab pegol: results from a randomised, controlled trial 査読有り Open Access

    Asai, S; Kojima, T; Ishikawa, H; Miyake, N; Kodera, M; Hasegawa, H; Sobue, Y; Kanayama, Y; Shimada, H; Hirano, Y; Hidaka, T; Fujibayashi, T; Matsumoto, T; Kobayakawa, T; Yasuoka, H; Kato, T; Hanabayashi, M; Kaneko, Y; Tada, M; Murata, K; Misaki, K; Ando, M; Kuwatsuka, Y; Suzuki, M; Terabe, K; Imagama, S

    ARTHRITIS RESEARCH & THERAPY   27 巻 ( 1 )   2025年4月

  26. Association between frailty and oral function in rheumatoid arthritis patients: A multi-center, observational study 査読有り Open Access

    Sobue, Y; Suzuki, M; Ohashi, Y; Sato, R; Ohno, Y; Hasegawa, J; Sugiura, T; Terabe, K; Asai, S; Imagama, S

    ARCHIVES OF RHEUMATOLOGY   40 巻 ( 1 ) 頁: 15 - 27   2025年3月

  27. Increased sputum peripheral helper T cells are associated with the severity of rheumatoid arthritis but not with the severity of airway disease 査読有り Open Access

    Yokoi, E; Wakahara, K; Nakamura, S; Fukutani, E; Asai, S; Takahashi, N; Kojima, T; Iwano, S; Shimada, S; Chen-Yoshikawa, TF; Hashimoto, N; Ishii, M

    FRONTIERS IN IMMUNOLOGY   16 巻   2025年2月

  28. The association between difficult-to-treat rheumatoid arthritis and probable sarcopenia 査読有り

    Ohashi, Y; Suzuki, M; Sobue, Y; Terabe, K; Asai, S; Takahashi, N; Imagama, S

    MODERN RHEUMATOLOGY     2025年1月

  29. Protocol: Filgotinib in addition to methotrexate versus filgotinib monotherapy in patients with rheumatoid arthritis with an inadequate response to methotrexate: A multicenter, prospective, open-label, randomized controlled trial (FAITHFUL Study) 査読有り Open Access

    Akiyama, M; Hidaka, T; Kaneko, M; Ito, S; Taguchi, H; Ishii, T; Asai, S; Hirata, S; Ikeda, K; Suzuki, K; Kato, N; Kaneko, Y

    PLOS ONE   20 巻 ( 5 )   2025年

  30. Associations of frailty with RA-ILD and poor control of disease activity in patients with rheumatoid arthritis: A multi-center retrospective observational study 査読有り

    Ohashi, Y; Takahashi, N; Sobue, Y; Suzuki, M; Sato, R; Maeda, M; Kihira, D; Kishimoto, K; Terabe, K; Asai, S; Imagama, S

    JOURNAL OF ORTHOPAEDIC SCIENCE   29 巻 ( 6 ) 頁: 1496 - 1502   2024年11月

  31. Clinical effectiveness of baricitinib and abatacept in patients with rheumatoid arthritis 査読有り

    Asai, S; Takahashi, N; Terabe, K; Yoshioka, Y; Kojima, T; Kobayakawa, T; Sobue, Y; Watanabe, T; Hirano, Y; Kanayama, Y; Kato, T; Hanabayashi, M; Suzuki, M; Imagama, S

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   27 巻 ( 11 )   2024年11月

  32. Clinical features of juvenile onset ankylosing spondylitis in Japanese patients 査読有り

    Kishimoto, K; Asai, S; Suzuki, M; Sato, R; Hasegawa, J; Terabe, K; Imagama, S

    MODERN RHEUMATOLOGY   35 巻 ( 1 ) 頁: 144 - 150   2024年9月

  33. Prevalence of social frailty in patients with rheumatoid arthritis: Data from a multicentre observational study (T-FLAG study) 査読有り

    Suzuki, M; Asai, S; Ohashi, Y; Sobue, Y; Ishikawa, H; Terabe, K; Sato, R; Kosugiyama, H; Hasegawa, J; Ohno, Y; Sugiura, T; Imagama, S

    MODERN RHEUMATOLOGY   35 巻 ( 2 ) 頁: 234 - 239   2024年9月

  34. Association between sarcopenia and locomotive syndrome in rheumatoid arthritis patients: A multicenter observational study (T-FLAG) 査読有り

    Sobue, Y; Suzuki, M; Ohashi, Y; Sato, R; Kosugiyama, H; Ohno, Y; Hasegawa, J; Sugiura, T; Terabe, K; Asai, S; Imagama, S

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   27 巻 ( 9 )   2024年9月

  35. Verification of grip strength as an evaluation tool for locomotive syndrome in rheumatoid arthritis 査読有り

    Sobue, Y; Suzuki, M; Ohashi, Y; Sato, R; Kosugiyama, H; Ohno, Y; Hasegawa, J; Sugiura, T; Terabe, K; Asai, S; Imagama, S

    OSTEOPOROSIS AND SARCOPENIA   10 巻 ( 3 ) 頁: 119 - 125   2024年9月

  36. Sacroiliac joint fusion in patients with ankylosing spondylitis is associated with hip involvement 査読有り

    Ido, H; Osawa, Y; Takegami, Y; Kishimoto, K; Kihira, D; Suzuki, M; Asai, S; Imagama, S

    JOURNAL OF ORTHOPAEDIC SCIENCE   29 巻 ( 4 ) 頁: 939 - 944   2024年7月

  37. ASSOCIATION OF FRAILTY AND PHYSICAL FUNCTION ASSESSMENT TO EXPLORE RHEUMATIC FRAILTY IN PATIENTS WITH RHEUMATOID ARTHRITIS FROM A PROSPECTIVE COHORT STUDY 査読有り

    Suzuki, M; Kojima, T; Sugiura, T; Saito, Y; Yamamoto, H; Terabe, K; Ohashi, Y; Sato, R; Kosugiyama, H; Hasegawa, J; Ohno, Y; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   83 巻   2024年6月

  38. EVALUATION OF PHYSICAL FUNCTION IN RHEUMATOID ARTHRITIS PATIENTS BY LOCOMOTIVE SYNDROME STAGE 査読有り

    Yamamoto, H; Suzuki, M; Sugiura, T; Saito, Y; Terabe, K; Sato, R; Kosugiyama, H; Hasegawa, J; Ohno, Y; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   83 巻   2024年6月

  39. NEGLECTING MENTAL HEALTH IN RHEUMATOID ARTHRITIS PATIENTS LEADS TO PROGRESSION INTO FRAILTY 査読有り

    Ohashi, Y; Takahashi, N; Suzuki, M; Sobue, Y; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   83 巻   2024年6月

  40. COMPARISON OF THE EFFECTS OF BARICITINIB AND ABATACEPT ON DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS: A PROPENSITY SCORE MATCHING ANALYSIS 査読有り

    Asai, S; Takahashi, N; Terabe, K; Yoshioka, Y; Kojima, T; Kobayakawa, T; Sobue, Y; Watanabe, T; Hirano, Y; Kanayama, Y; Kato, T; Hanabayashi, M; Suzuki, M; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   83 巻   頁: 763 - 764   2024年6月

  41. INEFFECTIVENESS OF CONTROLLING DISEASE ACTIVITY ALONE IN PREVENTING THE PROGRESSION OF RHEUMATIC FRAILTY IN RHEUMATOID ARTHRITIS PATIENTS 査読有り

    Ohashi, Y; Takahashi, N; Suzuki, M; Sobue, Y; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   83 巻   2024年6月

  42. FRAILTY IS ASSOCIATED WITH A LACK OF OPPORTUNITIES FOR VOCALIZATION IN RHEUMATOID ARTHRITIS PATIENTS 査読有り

    Sobue, Y; Suzuki, M; Ohashi, Y; Ishikawa, H; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   83 巻   2024年6月

  43. FRAILTY AS AN IMPORTANT INDICATOR FOR DIFFICULT-TO-TREAT RHEUMATOID ARTHRITIS FROM A MULTICENTER OBSERVATIONAL STUDY (T-FLAG STUDY) 査読有り

    Suzuki, M; Sobue, Y; Ohashi, Y; Erabe, KT; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   83 巻   2024年6月

  44. DIFFERENCES IN PHYSICAL FUNCTION AND BODY COMPOSITION BETWEEN LATE-ONSET AND YOUNG- ONSET RHEUMATOID ARTHRITIS (FAIRY STUDY) 査読有り Open Access

    Saito, Y; Suzuki, M; Sugiura, T; Yamamoto, H; Sato, R; Kosugiyama, H; Ohno, Y; Hasegawa, J; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   83 巻   2024年6月

  45. PNEUMOCYSTIS PNEUMONIA IN PATIENTS WITH RHEUMATOID ARTHRITIS-AICHI PREFECTURE DPC DATA 査読有り

    Sato, R; Imaizumi, T; Terabe, K; Hasegawa, J; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   83 巻   2024年6月

  46. SOCIAL FRAILTY IN PATIENTS WITH RHEUMATOID ARTHRITIS FROM A MULTICENTER OBSERVATIONAL STUDY (T-FLAG STUDY) 査読有り

    Suzuki, M; Sobue, Y; Ohashi, Y; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   83 巻   頁: 781 - 782   2024年6月

  47. RELATIONSHIP BETWEEN LAUGHTER AND PHYSICAL FUNCTION IN RHEUMATOID ARTHRITIS PATIENTS 査読有り

    Sobue, Y; Suzuki, M; Ohashi, Y; Ishikawa, H; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   83 巻   頁: 752 - 753   2024年6月

  48. PREDICTORS OF CLINICAL REMISSION IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH JAK INHIBITORS:THETBCR STUDY 査読有り

    Asai, S; Terabe, K; Takahashi, N; Yoshioka, Y; Watanabe, T; Kojima, T; Kobayakawa, T; Sobue, Y; Kanayama, Y; Matsumoto, T; Hirano, Y; Kato, T; Fujibayashi, T; Hanabayashi, M; Nishiume, T; Suzuki, M; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   83 巻   2024年6月

  49. Factors associated with discrepancies in disease activity as assessed by SDAI and RAPID3 in patients with rheumatoid arthritis: Data from a multicentre observational study (T-FLAG) 査読有り

    Suzuki, M; Asai, S; Ohashi, Y; Sobue, Y; Ishikawa, H; Takahashi, N; Terabe, K; Sato, R; Kosugiyama, H; Hasegawa, J; Ohno, Y; Sugiura, T; Imagama, S

    MODERN RHEUMATOLOGY   35 巻 ( 1 ) 頁: 57 - 63   2024年5月

  50. Choice of and response to treatment in patients with early-diagnosed rheumatoid arthritis: Real-world data from an inception cohort in Japan (NICER-J) 査読有り

    Suzuki, M; Asai, S; Hara, R; Hirano, Y; Nagamine, S; Kaneko, T; Sakane, H; Okano, T; Yoshioka, Y; Tsuji, S; Wakabayashi, H; Takakubo, Y; Takemoto, T; Fujibayashi, T; Watanabe, T; Kato, T; Ishikawa, H; Nasu, Y; Torikai, E; Kaneko, A; Takagi, H; Fujiwara, T; Kihira, D; Hattori, K; Kishimoto, K; Ohashi, Y; Sobue, Y; Yokota, Y; Nishiume, T; Terabe, K; Takahashi, N; Kojima, M; Imagama, S; Kojima, T

    JOURNAL OF ORTHOPAEDIC SCIENCE   29 巻 ( 3 ) 頁: 921 - 926   2024年5月

  51. Intervertebral fusion sites in patients with ankylosing spondylitis: A computed tomography study 査読有り

    Kishimoto, K; Asai, S; Suzuki, M; Kihira, D; Sato, R; Terabe, K; Ohashi, Y; Maeda, M; Imagama, S

    MODERN RHEUMATOLOGY   34 巻 ( 3 ) 頁: 599 - 606   2024年3月

  52. Consensus statement on the management of late-onset rheumatoid arthritis 査読有り

    Kojima, M; Sugihara, T; Kawahito, Y; Kojima, T; Kaneko, Y; Ishikawa, H; Abe, A; Matsui, K; Hirata, S; Kishimoto, M; Tanaka, E; Morinobu, A; Hashimoto, M; Matsushita, I; Hidaka, T; Matsui, T; Nishida, K; Asai, S; Ito, H; Harada, R; Harigai, M

    MODERN RHEUMATOLOGY   34 巻 ( 6 ) 頁: 1095 - 1102   2024年3月

  53. Comparison of effectiveness of methotrexate in patients with late-onset versus younger-onset rheumatoid arthritis: Real-world data from an inception cohort in Japan (NICER-J) 査読有り

    Asai, S; Suzuki, M; Hara, R; Hirano, Y; Nagamine, S; Kaneko, T; Suto, T; Okano, T; Yoshioka, Y; Hirao, M; Wakabayashi, H; Fujibayashi, T; Watanabe, T; Takakubo, Y; Ishikawa, H; Nasu, Y; Takemoto, T; Kato, T; Torikai, E; Koyama, K; Takagi, H; Fujiwara, T; Sobue, Y; Ohashi, Y; Nishiume, T; Terabe, K; Kojima, M; Kojima, T; Imagama, S

    MODERN RHEUMATOLOGY   34 巻 ( 5 ) 頁: 892 - 899   2024年3月

  54. Association between laughter, frailty, and depression in rheumatoid arthritis patients 査読有り

    Suzuki, M; Kojima, T; Terabe, K; Ohashi, Y; Sato, R; Kosugiyama, H; Hasegawa, J; Ohno, Y; Nagai, K; Ohnishi, C; Sugiura, H; Fujita, H; Nagayoshi, M; Kojima, M; Asai, S; Imagama, S

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   27 巻 ( 1 )   2024年1月

  55. Disease activity at baseline is an independent predictor of frailty at one year in pre-frail patients with rheumatoid arthritis; a multicenter retrospective observational study 査読有り

    Ohashi, Y; Takahashi, N; Sobue, Y; Suzuki, M; Hattori, K; Kishimoto, K; Terabe, K; Asai, S; Kojima, T; Kojima, M; Imagama, S

    JOURNAL OF ORTHOPAEDIC SCIENCE   29 巻 ( 1 ) 頁: 315 - 320   2024年1月

  56. Well-controlled disease activity with drug treatment will not improve the frailty status of RA patients to robust state: A multicenter observational study (T-FLAG) 査読有り

    Ohashi, Y; Takahashi, N; Sobue, Y; Suzuki, M; Sato, R; Maeda, M; Terabe, K; Asai, S; Imagama, S

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   27 巻 ( 1 )   2024年1月

  57. Relationship between locomotive syndrome and large joint symptoms in rheumatoid arthritis patients 査読有り

    Sobue, Y; Suzuki, M; Ohashi, Y; Koshima, H; Okui, N; Funahashi, K; Ishikawa, H; Inoue, H; Asai, S; Terabe, K; Maeda, M; Sato, R; Kosugiyama, H; Ohno, Y; Imagama, S

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   27 巻 ( 1 )   2024年1月

  58. A Preliminary Survey of Rheumatologists on the Management of Late-onset Rheumatoid Arthritis in Japan 査読有り

    Takanashi, S; Kaneko, Y; Kawahito, Y; Kida, T; Sugihara, T; Kojima, T; Harada, R; Ishitoku, M; Hirata, S; Hashimoto, M; Hidaka, T; Abe, A; Ishikawa, H; Ito, H; Kishimoto, M; Matsui, K; Matsui, T; Matsushita, I; Onishi, A; Morinobu, A; Nishida, K; Asai, S; Tanaka, E; Harigai, M; Kojima, M

    INTERNAL MEDICINE   63 巻 ( 24 ) 頁: 3299 - 3306   2024年

  59. Increased prevalence of<i> Staphylococcus</i><i> aureus</i> nasal carriage in rheumatoid arthritis patients with moderate/high disease activity 査読有り

    Asai, S; Takahashi, N; Kishimoto, K; Suzuki, M; Ohashi, Y; Terabe, K; Kojima, T; Imagama, S

    JOURNAL OF ORTHOPAEDIC SCIENCE   28 巻 ( 6 ) 頁: 1400 - 1406   2023年11月

  60. Relationship Between Frailty and Large Joint Symptoms in Rheumatoid Arthritis Patients 査読有り

    Sobue, Y; Suzuki, M; Ohashi, Y; Asai, S; Imagama, S

    ARTHRITIS & RHEUMATOLOGY   75 巻   頁: 4154 - 4155   2023年10月

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  61. Usefulness of RAPID3 in Assessing Unmet Needs of Patients with Rheumatoid Arthritis in Remission or with Low Disease Activity -a Multicenter Observational Study: T-FLAG Study- 査読有り

    Suzuki, M; Takahashi, N; Sobue, Y; Ohashi, Y; Sato, R; Maeda, M; Kosugiyama, H; Ohno, Y; Terabe, K; Asai, S; Imagama, S

    ARTHRITIS & RHEUMATOLOGY   75 巻   頁: 797 - 799   2023年10月

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  62. The Impact of Patient-reported Outcomes on Boolean 2.0 Remission Criteria in Rheumatoid Arthritis Patients in Real Clinical Practice -a Multicenter Observational Study: T-FLAG Study- 査読有り

    Suzuki, M; Ohashi, Y; Sobue, Y; Sato, R; Maeda, M; Kosugiyama, H; Ohno, Y; Terabe, K; Asai, S; Imagama, S

    ARTHRITIS & RHEUMATOLOGY   75 巻   頁: 799 - 800   2023年10月

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  63. Reasons and risk factors for discontinuation of treatment with any biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: A long-term observational study 査読有り

    Terabe, K; Takahashi, N; Asai, S; Hirano, Y; Kanayama, Y; Yabe, Y; Oguchi, T; Fujibayashi, T; Ishikawa, H; Hanabayashi, M; Hattori, Y; Suzuki, M; Kishimoto, K; Ohashi, Y; Imaizumi, T; Imagama, S; Kojima, T

    MODERN RHEUMATOLOGY   33 巻 ( 5 ) 頁: 891 - 898   2023年8月

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    記述言語:英語  

    DOI: 10.1093/mr/roac090

    Web of Science

    PubMed

  64. Relationship between frailty and methotrexate discontinuation due to adverse events in rheumatoid arthritis patients 査読有り

    Sobue, Y; Suzuki, M; Ohashi, Y; Koshima, H; Okui, N; Funahashi, K; Ishikawa, H; Inoue, H; Asai, S; Terabe, K; Kishimoto, K; Kihira, D; Maeda, M; Sato, R; Imagama, S

    CLINICAL RHEUMATOLOGY   42 巻 ( 8 ) 頁: 2069 - 2077   2023年8月

  65. Age and symptoms at onset of ankylosing spondylitis in Japanese patients 査読有り

    Kishimoto, K; Asai, S; Suzuki, M; Takahashi, N; Terabe, K; Ohashi, Y; Hattori, K; Kojima, T; Imagama, S

    MODERN RHEUMATOLOGY   33 巻 ( 4 ) 頁: 817 - 822   2023年7月

  66. Periprosthetic humeral fracture revision using a massive allograft in a patient with rheumatoid arthritis: A case report 査読有り Open Access

    Kishimoto, K; Kojima, T; Takahashi, N; Asai, S; Terabe, K; Suzuki, M; Ohashi, Y; Kihira, D; Maeda, M; Tatebe, M; Imagama, S

    MODERN RHEUMATOLOGY CASE REPORTS   7 巻 ( 2 ) 頁: 359 - 363   2023年6月

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  67. A STUDY OF REVERSIBILITY OF FRAILTY IN RHEUMATOID ARTHRITIS FROM THE T-FLAG STUDY 査読有り Open Access

    Suzuki, M; Sobue, Y; Ohashi, Y; Sato, R; Kihira, D; Maeda, M; Kishimoto, K; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   82 巻   頁: 1294 - 1295   2023年6月

  68. CONSIDERATIONS OF REALISTIC TREATMENT GOALS BASED ON PREDICTORS OF FRAILTY PROGRESSION IN PRE-FRAIL PATIENTS WITH RHEUMATOID ARTHRITIS: A MULTICENTER RETROSPECTIVE OBSERVATIONAL STUDY. 査読有り Open Access

    Ohashi, Y; Takahashi, N; Sobue, Y; Suzuki, M; Sato, R; Maeda, M; Kihira, D; Kishimoto, K; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   82 巻   頁: 1275 - 1275   2023年6月

  69. USEFULNESS OF RAPID3 IN ASSESSING UNMET NEEDS OF RHEUMATOID ARTHRITIS PATIENTS FROM THE T-FLAG STUDY 査読有り Open Access

    Suzuki, M; Takahashi, N; Sobue, Y; Ohashi, Y; Sato, R; Maeda, M; Kihira, D; Kishimoto, K; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   82 巻   頁: 1303 - 1304   2023年6月

  70. THE ASSOCIATION BETWEEN LAUGHTER AND FRAILTY IN PATIENTS WITH RHEUMATOID ARTHRITIS FROM THE FAIRY STUDY 査読有り Open Access

    Suzuki, M; Kojima, T; Ohashi, Y; Sato, R; Kihira, D; Maeda, M; Kishimoto, K; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   82 巻   頁: 1294 - 1294   2023年6月

  71. RHEUMATOID ARTHRITIS PATIENTS WITH INTERSTITIAL PNEUMONIA NEED APPROPRIATE TREATMENT ENHANCEMENT TO RECOVER FROM FRAILTY: A MULTICENTER RETROSPECTIVE OBSERVATIONAL STUDY 査読有り Open Access

    Ohashi, Y; Takahashi, N; Suzuki, M; Sobue, Y; Sato, R; Maeda, M; Kihira, D; Kishimoto, K; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   82 巻   頁: 1325 - 1325   2023年6月

  72. RELATIONSHIP BETWEEN ANKYLOSIS AND PHYSICAL FUNCTION ASSESSMENT IN ANKYLOSING SPONDYLITIS 査読有り Open Access

    Suzuki, M; Kishimoto, K; Kihira, D; Sato, R; Hasegawa, J; Maeda, M; Ohashi, Y; Terabe, K; Asai, S; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   82 巻   頁: 1741 - 1741   2023年6月

  73. DOES FRAILTY PREDICT METHOTREXATE DISCONTINUATION DUE TO ADVERSE EVENTS IN RHEUMATOID ARTHRITIS PATIENTS? 査読有り Open Access

    Sobue, Y; Asai, S; Suzuki, M; Ohashi, Y; Imagama, S

    ANNALS OF THE RHEUMATIC DISEASES   82 巻   頁: 1344 - 1345   2023年6月

  74. Effectiveness of tacrolimus concomitant with biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis 査読有り

    Terabe, K; Takahashi, N; Asai, S; Hirano, Y; Kanayama, Y; Yabe, Y; Oguchi, T; Fujibayashi, T; Ishikawa, H; Hanabayashi, M; Hattori, Y; Suzuki, M; Kishimoto, K; Ohashi, Y; Imaizumi, T; Imagama, S; Kojima, T

    MODERN RHEUMATOLOGY   33 巻 ( 2 ) 頁: 292 - 301   2023年3月

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    記述言語:英語  

    DOI: 10.1093/mr/roac025

    Web of Science

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  75. Factors associated with frailty in rheumatoid arthritis patients with decreased renal function 査読有り

    Ohashi, Y; Takahashi, N; Sobue, Y; Suzuki, M; Hattori, K; Kishimoto, K; Terabe, K; Asai, S; Kojima, T; Kojima, M; Imagama, S

    MODERN RHEUMATOLOGY   33 巻 ( 2 ) 頁: 323 - 329   2023年3月

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    記述言語:英語  

    DOI: 10.1093/mr/roac018

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  76. Late-onset rheumatoid arthritis registry study, LORIS study: study protocol and design 査読有り Open Access

    Kojima Masayo, Kawahito Yutaka, Sugihara Takahiko, Kojima Toshihisa, Harada Ryozo, Hirata Shintaro, Hashimoto Motomu, Hidaka Toshihiko, Ishikawa Hajime, Ito Hiromu, Kishimoto Mitsumasa, Kaneko Yuko, Matsui Kazuo, Matsui Toshihiro, Matsushita Isao, Morinobu Akio, Nishida Keiichiro, Tanaka Eiichi, Abe Asami, Ishitoku Michinori, Asai Shuji, Kida Takashi, Onishi Akira, Takanashi Satoshi, Harigai Masayoshi

    BMC RHEUMATOLOGY   6 巻 ( 1 )   2022年12月

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  77. Locomotive syndrome in rheumatoid arthritis patients during the COVID-19 pandemic 査読有り Open Access

    Sobue Yasumori, Suzuki Mochihito, Ohashi Yoshifumi, Koshima Hiroshi, Okui Nobuyuki, Funahashi Koji, Ishikawa Hisato, Inoue Hidenori, Kojima Masayo, Asai Shuji, Terabe Kenya, Hattori Kyosuke, Kishimoto Kenji, Takahashi Nobunori, Imagama Shiro, Kojima Toshihisa

    NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 4 ) 頁: 799 - 812   2022年11月

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  78. Association between locomotive syndrome and methotrexate discontinuation due to adverse events in rheumatoid arthritis patients: A retrospective observational study 査読有り

    Sobue Yasumori, Suzuki Mochihito, Ohashi Yoshifumi, Koshima Hiroshi, Okui Nobuyuki, Funahashi Koji, Ishikawa Hisato, Inoue Hidenori, Kojima Masayo, Asai Shuji, Terabe Kenya, Hattori Kyosuke, Kishimoto Kenji, Takahashi Nobunori, Imagama Shiro, Kojima Toshihisa

    GERIATRICS & GERONTOLOGY INTERNATIONAL   22 巻 ( 10 ) 頁: 904 - 906   2022年10月

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    記述言語:英語  

    DOI: 10.1111/ggi.14475

    Web of Science

  79. Changes in perioperative C-reactive protein levels in patients with rheumatoid arthritis undergoing total knee arthroplasty in the biologic era Open Access

    Kishimoto Kenji, Asai Shuji, Takahashi Nobunori, Terabe Kenya, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki, Kojima Toshihisa

    NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 2 ) 頁: 286 - 300   2022年5月

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    担当区分:責任著者   記述言語:英語  

    DOI: 10.18999/nagjms.84.2.286

    Open Access

    Web of Science

  80. Influence of frailty on patient global assessment in rheumatoid arthritis 査読有り Open Access

    Suzuki Mochihito, Asai Shuji, Sobue Yasumori, Ohashi Yoshifumi, Koshima Hiroshi, Okui Nobuyuki, Ishikawa Hisato, Takahashi Nobunori, Terabe Kenya, Kishimoto Kenji, Hattori Kyosuke, Imagama Shiro, Kojima Toshihisa

    GERIATRICS & GERONTOLOGY INTERNATIONAL   22 巻 ( 5 ) 頁: 399 - 404   2022年5月

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    担当区分:責任著者   記述言語:英語  

    DOI: 10.1111/ggi.14375

    Open Access

    Web of Science

  81. Relationship between locomotive syndrome and frailty in rheumatoid arthritis patients by locomotive syndrome stage. 査読有り

    Sobue Y, Suzuki M, Ohashi Y, Koshima H, Okui N, Funahashi K, Ishikawa H, Asai S, Terabe K, Yokota Y, Kishimoto K, Takahashi N, Imagama S, Kojima T

    Modern rheumatology     2021年9月

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    記述言語:英語  

    DOI: 10.1093/mr/roab024

    PubMed

  82. Depression, physical function, and disease activity associated with frailty in patients with rheumatoid arthritis 査読有り

    Kojima Masayo, Kojima Toshihisa, Waguri-Nagaya Yuko, Takahashi Nobunori, Asai Shuji, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Mitsui Hiroto, Kawaguchi Yohei, Kuroyanagi Gen, Yasuoka Mikako, Watanabe Miki, Suzuki Sadao, Arai Hidenori

    MODERN RHEUMATOLOGY   31 巻 ( 5 ) 頁: 979 - 986   2021年9月

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  83. Impact of social support on severity of depressive symptoms by remission status in patients with rheumatoid arthritis. 査読有り

    Yasuoka M, Kojima T, Waguri-Nagaya Y, Saito T, Takahashi N, Asai S, Sobue Y, Nishiume T, Suzuki M, Mitsui H, Kawaguchi Y, Kuroyanagi G, Kamiji K, Watanabe M, Suzuki S, Kondo K, Ojima T, Kojima M

    Modern rheumatology     2021年8月

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    記述言語:英語  

    DOI: 10.1093/mr/roab001

    PubMed

  84. Comparison of the effects of baricitinib and tocilizumab on disease activity in patients with rheumatoid arthritis: a propensity score matching analysis 査読有り

    Asai Shuji, Takahashi Nobunori, Kobayakawa Tomonori, Kaneko Atsushi, Watanabe Tatsuo, Kato Takefumi, Nishiume Tsuyoshi, Ishikawa Hisato, Yoshioka Yutaka, Kanayama Yasuhide, Watanabe Tsuyoshi, Hirano Yuji, Hanabayashi Masahiro, Yabe Yuichiro, Yokota Yutaka, Suzuki Mochihito, Terabe Kenya, Ishiguro Naoki, Imagama Shiro, Kojima Toshihisa

    CLINICAL RHEUMATOLOGY   40 巻 ( 8 ) 頁: 3143 - 3151   2021年8月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語  

    DOI: 10.1007/s10067-021-05815-3

    Web of Science

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  85. Higher doses of methotrexate associated with discontinuation of oral glucocorticoids after initiation of biological DMARDs: A retrospective observational study based on data from a Japanese multicenter registry study 査読有り Open Access

    Suzuki Mochihito, Kojima Toshihisa, Takahashi Nobunori, Asai Shuji, Terabe Kenya, Kaneko Atsushi, Hirano Yuji, Hanabayashi Masahiro, Oguchi Takeshi, Takagi Hideki, Kanayama Yasuhide, Yabe Yuichiro, Funahashi Koji, Fujibayashi Takayoshi, Tsuboi Seiji, Ito Takayasu, Yoshioka Yutaka, Ishikawa Hisato, Sobue Yasumori, Nishiume Tsuyoshi, Yokota Yutaka, Ishiguro Naoki

    MODERN RHEUMATOLOGY   31 巻 ( 4 ) 頁: 796 - 802   2021年7月

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  86. REASONS AND RISK FACTOR FOR DISCONTINUATION OF BIOLOGIC AGENTS FOR RHEUMATOID ARTHRITIS PATIENTS IN LONG-TERM OBSERVATION 査読有り Open Access

    Terabe K., Takahashi N., Asai S., Hirano Y., Kanayama Y., Kojima T.

    ANNALS OF THE RHEUMATIC DISEASES   80 巻   頁: 1142 - 1143   2021年6月

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  87. Fifteen-year trends in the number and age of patients with rheumatoid arthritis undergoing total knee and hip arthroplasty: A comparison study with osteoarthritis 査読有り

    Asai Shuji, Takemoto Toki, Takahashi Nobunori, Oguchi Takeshi, Ishiguro Naoki, Kojima Toshihisa

    MODERN RHEUMATOLOGY   31 巻 ( 3 ) 頁: 768 - 771   2021年5月

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  88. Relationship between the physician-based clinical scale for foot and ankle surgery and patient-reported outcomes in patients with long-standing rheumatoid arthritis: Results from a multicenter prospective observational cohort study 査読有り Open Access

    Kojima Toshihisa, Ishikawa Hajime, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Kojima Masayo, Ishiguro Naoki

    MODERN RHEUMATOLOGY   31 巻 ( 3 ) 頁: 607 - 613   2021年5月

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  89. Relationship between disease activity of rheumatoid arthritis and development of locomotive syndrome: A five-year longitudinal cohort study 査読有り

    Sobue Yasumori, Kojima Toshihisa, Funahashi Koji, Okui Nobuyuki, Takahashi Nobunori, Asai Shuji, Terabe Kenya, Nishiume Tsuyoshi, Suzuki Mochihito, Yokota Yutaka, Ohashi Yoshifumi, Ishiguro Naoki

    MODERN RHEUMATOLOGY   31 巻 ( 1 ) 頁: 101 - 107   2021年1月

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  90. Predictors for clinical effectiveness of baricitinib in rheumatoid arthritis patients in routine clinical practice: data from a Japanese multicenter registry 査読有り Open Access

    Takahashi Nobunori, Asai Shuji, Kobayakawa Tomonori, Kaneko Atsushi, Watanabe Tatsuo, Kato Takefumi, Nishiume Tsuyoshi, Ishikawa Hisato, Yoshioka Yutaka, Kanayama Yasuhide, Watanabe Tsuyoshi, Hirano Yuji, Hanabayashi Masahiro, Yabe Yuichiro, Yokota Yutaka, Suzuki Mochihito, Sobue Yasumori, Terabe Kenya, Ishiguro Naoki, Kojima Toshihisa

    SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁: 21907   2020年12月

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  91. Predictors of disease flare after discontinuation of concomitant methotrexate in Japanese patients with rheumatoid arthritis treated with tocilizumab 査読有り Open Access

    Asai Shuji, Takahashi Nobunori, Hayashi Masatoshi, Hanabayashi Masahiro, Kanayama Yasuhide, Takemoto Toki, Yabe Yuichiro, Shioura Tomone, Ishikawa Hisato, Yoshioka Yutaka, Kato Takefumi, Hirano Yuji, Fujibayashi Takayoshi, Hattori Yosuke, Kobayakawa Tomonori, Ando Masahiko, Kuwatsuka Yachiyo, Matsumoto Takuya, Asai Nobuyuki, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki, Kojima Toshihisa

    JOINT BONE SPINE   87 巻 ( 6 ) 頁: 596 - 602   2020年12月

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    担当区分:筆頭著者   記述言語:英語  

    DOI: 10.1016/j.jbspin.2020.06.001

    Open Access

    Web of Science

    PubMed

  92. A retrospective analysis of the relationship between anti-cyclic citrullinated peptide antibody and the effectiveness of abatacept in rheumatoid arthritis patients 査読有り Open Access

    Kida Daihei, Takahashi Nobunori, Kaneko Atsushi, Hirano Yuji, Fujibayashi Takayoshi, Kanayama Yasuhide, Hanabayashi Masahiro, Yabe Yuichiro, Takagi Hideki, Oguchi Takeshi, Kato Takefumi, Funahashi Koji, Matsumoto Takuya, Ando Masahiko, Kuwatsuka Yachiyo, Tanaka Eiichi, Yasuoka Hidekata, Kaneko Yuko, Hirata Shintaro, Murakami Kosaku, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Yokota Yutaka, Terabe Kenya, Asai Shuji, Ishiguro Naoki, Kojima Toshihisa

    SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁: 19717   2020年11月

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  93. Periarticular osteophyte formation protects against total knee arthroplasty in rheumatoid arthritis patients with advanced joint damage 査読有り Open Access

    Asai Shuji, Takahashi Nobunori, Terabe Kenya, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Yokota Yutaka, Ishiguro Naoki, Kojima Toshihisa

    CLINICAL RHEUMATOLOGY   39 巻 ( 11 ) 頁: 3331 - 3339   2020年11月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.1007/s10067-020-05140-1

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  94. Factors associated with osteophyte formation in patients with rheumatoid arthritis undergoing total knee arthroplasty 査読有り

    Asai Nobuyuki, Asai Shuji, Takahashi Nobunori, Ishiguro Naoki, Kojima Toshihisa

    MODERN RHEUMATOLOGY   30 巻 ( 5 ) 頁: 937 - 939   2020年9月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.1080/14397595.2019.1673132

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  95. Improvement in matrix metalloproteinase-3 independently predicts low disease activity at 52 weeks in bio-switch rheumatoid arthritis patients treated with abatacept. 査読有り

    Takemoto T, Takahashi N, Kida D, Kaneko A, Hirano Y, Fujibayashi T, Kanayama Y, Hanabayashi M, Yabe Y, Takagi H, Oguchi T, Kato T, Funahashi K, Matsumoto T, Sobue Y, Nishiume T, Suzuki M, Yokota Y, Terabe K, Asai S, Ishiguro N, Kojima T

    Clinical and experimental rheumatology   38 巻 ( 5 ) 頁: 933 - 939   2020年9月

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    記述言語:英語  

    PubMed

  96. Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: A 14-year trend analysis (2004-2017) 査読有り Open Access

    Asai Shuji, Takahashi Nobunori, Asai Nobuyuki, Yamashita Satoshi, Terabe Kenya, Matsumoto Takuya, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki, Kojima Toshihisa

    MODERN RHEUMATOLOGY   30 巻 ( 4 ) 頁: 657 - 663   2020年7月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.1080/14397595.2019.1649111

    Open Access

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  97. COMPARATIVE STUDY OF PATIENT BACKGROUND AND TREATMENT OUTCOME BY BARICITINIB DOSE UNDER REAL CLINICAL CONDITIONS. 査読有り

    Nishiume T., Takahashi N., Kojima T., Asai S., Terabe K., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   79 巻   頁: 1472 - 1473   2020年6月

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  98. EFFECTIVENESS OF ABATACEPT ON CLINICAL DISEASE ACTIVITY AND RADIOGRAPHIC PROGRESSION IN RHEUMATOID ARTHRITIS PATIENTS IN DAILY CLINICAL PRACTICE IN JAPAN: COMPARISONS ACCORDING TO ACPA STATUS 査読有り

    Takahashi N., Kojima T., Asai S., Terabe K., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   79 巻   頁: 629 - 630   2020年6月

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  99. THE EFFECTIVENESS OF BIOLOGICAL AGENTS CONCOMITANT WITH TACROLIMUS IN RHEUMATOID ARTHRITIS 査読有り Open Access

    Terabe K., Takahashi N., Asai S., Kaneko A., Hirano Y., Kanayama Y., Yabe Y., Kojima T., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   79 巻   頁: 304 - 305   2020年6月

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  100. PREDICTORS OF DISEASE FLARE AFTER DISCONTINUATION OF CONCOMITANT METHOTREXATE IN JAPANESE PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH TOCILIZUMAB 査読有り Open Access

    Asai S., Takahashi N., Kuwatsuka Y., Ando M., Ishiguro N., Kojima T.

    ANNALS OF THE RHEUMATIC DISEASES   79 巻   頁: 252 - 253   2020年6月

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    担当区分:筆頭著者   記述言語:英語  

    DOI: 10.1136/annrheumdis-2020-eular.1095

    Open Access

    Web of Science

  101. PREDICTORS FOR SHORT-TERM CLINICAL EFFECTIVENESS OF BARICITINIB IN RHEUMATOID ARTHRITIS PATIENTS IN ROUTINE CLINICAL PRACTICE: DATA FROM A JAPANESE MULTICENTER REGISTRY 査読有り

    Takahashi N., Kojima T., Asai S., Terabe K., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   79 巻   頁: 646 - 646   2020年6月

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  102. PERIARTICULAR OSTEOPHYTE FORMATION PROTECTS AGAINST TOTAL KNEE ARTHROPLASTY IN RHEUMATOID ARTHRITIS PATIENTS WITH ADVANCED JOINT DAMAGE 査読有り Open Access

    Asai S., Takahashi N., Terabe K., Kojima T., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   79 巻   頁: 1384 - 1385   2020年6月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.1136/annrheumdis-2020-eular.1209

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  103. IMPROVEMENT OF DEPRESSION BY JOINT SURGERY IN ESTABLISHED RHEUMATOID ARTHRITIS; RESULTS FROM MULTICENTER PROSPECTIVE COHORT STUDY FOR EVALUATION OF JOINT SURGERY ON PATIENT'S REPORTED OUTCOME 査読有り Open Access

    Kojima T., Kojima M., Ishikawa H., Nishida K., Asai S., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   79 巻   頁: 1872 - 1873   2020年6月

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  104. HIGHER DOSES OF METHOTREXATE ASSOCIATED WITH DISCONTINUATION OF ORAL GLUCOCORTICOIDS AFTER INITIATION OF BIOLOGICAL DMARDS: A RETROSPECTIVE OBSERVATIONAL STUDY BASED ON DATA FROM A JAPANESE MULTICENTER REGISTRY STUDY 査読有り Open Access

    Suzuki M., Kojima T., Takahashi N., Asai S., Terabe K., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   79 巻   頁: 991 - 992   2020年6月

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  105. Discontinuation of concomitant methotrexate in Japanese patients with rheumatoid arthritis treated with tocilizumab: An interventional study 査読有り Open Access

    Asai Shuji, Hayashi Masatoshi, Hanabayashi Masahiro, Kanayama Yasuhide, Takemoto Toki, Yabe Yuichiro, Shioura Tomone, Ishikawa Hisato, Yoshioka Yutaka, Kato Takefumi, Hirano Yuji, Fujibayashi Takayoshi, Hattori Yosuke, Kobayakawa Tomonori, Ando Masahiko, Kuwatsuka Yachiyo, Takahashi Nobunori, Matsumoto Takuya, Asai Nobuyuki, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki, Kojima Toshihisa

    MODERN RHEUMATOLOGY   30 巻 ( 3 ) 頁: 434 - 441   2020年5月

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    担当区分:筆頭著者   記述言語:英語  

    DOI: 10.1080/14397595.2019.1641934

    Open Access

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  106. Targetable driver mutations in multicentric reticulohistiocytosis 査読有り Open Access

    Murakami Norihiro, Sakai Tomohisa, Arai Eisuke, Muramatsu Hideki, Ichikawa Daisuke, Asai Shuji, Shimoyama Yoshie, Ishiguro Naoki, Takahashi Yoshiyuki, Okuno Yusuke, Nishida Yoshihiro

    HAEMATOLOGICA   105 巻 ( 2 ) 頁: E61 - E64   2020年1月

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  107. Improvement in matrix metalloproteinase-3 independently predicts low disease activity at 52 weeks in bio-switch rheumatoid arthritis patients treated with abatacept 査読有り

    Takemoto T., Takahashi N., Kida D., Kaneko A., Hirano Y., Fujibayashi T., Kanayama Y., Hanabayashi M., Yabe Y., Takagi H., Oguchi T., Kato T., Funahashi K., Matsumoto T., Sobue Y., Nishiume T., Suzuki M., Yokota Y., Terabe K., Asai S., Ishiguro N., Kojima T.

    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY   38 巻 ( 5 ) 頁: 933 - 939   2020年

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    記述言語:英語  

    Web of Science

  108. Clinical effectiveness and safety of additional administration of tacrolimus in rheumatoid arthritis patients with an inadequate response to abatacept: A retrospective cohort study 査読有り

    Suzuki Mochihito, Takahashi Nobunori, Kida Daihei, Hirano Yuji, Kato Takefumi, Yabe Yuichiro, Oguchi Takeshi, Fujibayashi Takayoshi, Hayashi Masatoshi, Asai Shuji, Ishiguro Naoki, Kojima Toshihisa

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   22 巻 ( 12 ) 頁: 2199 - 2205   2019年12月

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  109. Clinical effectiveness and long-term retention of abatacept in elderly rheumatoid arthritis patients: Results from a multicenter registry system 査読有り

    Takahashi Nobunori, Kojima Toshihisa, Kida Daihei, Kaneko Atsushi, Hirano Yuji, Fujibayashi Takayoshi, Yabe Yuichiro, Takagi Hideki, Oguchi Takeshi, Hanabayashi Masahiro, Kato Takefumi, Funahashi Koji, Hayashi Masatoshi, Tsuboi Seiji, Kanayama Yasuhide, Sobue Yasumori, Asai Nobuyuki, Matsumoto Takuya, Watanabe Tatsuo, Asai Shuji, Ishiguro Naoki

    MODERN RHEUMATOLOGY   29 巻 ( 6 ) 頁: 910 - 918   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/14397595.2018.1525019

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  110. Association between seropositivity and discontinuation of tumor necrosis factor inhibitors due to ineffectiveness in rheumatoid arthritis 査読有り

    Ogawa Yoshikazu, Takahashi Nobunori, Kaneko Atsushi, Hirano Yuji, Kanayama Yasuhide, Yabe Yuichiro, Oguchi Takeshi, Fujibayashi Takayoshi, Takagi Hideki, Hanabayashi Masahiro, Funahashi Koji, Hayashi Masatoshi, Tsuboi Seiji, Asai Shuji, Asai Nobuyuki, Matsumoto Takuya, Sobue Yasumori, Ishiguro Naoki, Kojima Toshihisa

    CLINICAL RHEUMATOLOGY   38 巻 ( 10 ) 頁: 2757 - 2763   2019年10月

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  111. Improving Depression by Joint Surgery in Established Rheumatoid Arthritis; Results from Multicenter Prospective Cohort Study for Evaluation of Joint Surgery on Patient's Reported Outcome 査読有り

    Kojima Toshihisa, Kojima Masayo, Ishikawa Hajime, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   71 巻   2019年10月

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    記述言語:英語  

    Web of Science

  112. Improvement in Matrix metalloproteinase-3 Levels at 12 Weeks Independently Predicts Achievement of Low Disease Activity at 52 Weeks in Bio-switch Patients with Rheumatoid Arthritis Treated with Abatacept 査読有り

    Takahashi Nobunori, Kojima Toshihisa, Terabe Kenya, Asai Shuji, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   71 巻   2019年10月

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    記述言語:英語  

    Web of Science

  113. Discontinuation of Oral Glucocorticoid After Initiation of Biological DMARDs Due to a Higher Dose of Methotrexate; A Retrospective Observational Study Based on Data from a Japanese Multicenter Registry Study 査読有り

    Suzuki Mochihito, Kojima Toshihisa, Takahashi Nobunori, Asai Shuji, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   71 巻   2019年10月

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    記述言語:英語  

    Web of Science

  114. Discontinuation of Concomitant Methotrexate in Japanese Patients with Rheumatoid Arthritis Treated with Tocilizumab: An Interventional Study 査読有り Open Access

    Kojima Toshihisa, Asai Shuji, Hanabayashi Masahiro, Hayashi Masatoshi, Takahashi Nobunori, Kuwatsuka Yachiyo, Ando Masahiko, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   71 巻   2019年10月

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  115. Characteristics of Patients with Rheumatoid Arthritis Undergoing Primary Total Joint Replacement: A 14-year Trend Analysis (2004-2017) 査読有り Open Access

    Asai Shuji, Kojima Toshihisa, Takahashi Nobunori, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   71 巻   2019年10月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.18999/nagjms.80.3.417

    Open Access

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  116. Concomitant methotrexate has little effect on clinical outcomes of abatacept in rheumatoid arthritis: a propensity score matching analysis 査読有り

    Takahashi Nobunori, Kojima Toshihisa, Kida Daihei, Kaneko Atsushi, Hirano Yuji, Fujibayashi Takayoshi, Yabe Yuichiro, Takagi Hideki, Oguchi Takeshi, Hanabayashi Masahiro, Kato Takefumi, Funahashi Koji, Hayashi Masatoshi, Tsuboi Seiji, Kanayama Yasuhide, Sobue Yasumori, Asai Nobuyuki, Matsumoto Takuya, Watanabe Tatsuo, Asai Shuji, Ishiguro Naoki

    CLINICAL RHEUMATOLOGY   38 巻 ( 9 ) 頁: 2451 - 2459   2019年9月

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  117. Relationship between rheumatoid arthritis and locomotive syndrome: validation of the 25-question Geriatric Locomotive Function Scale in patients with rheumatoid arthritis 査読有り Open Access

    Sobue Yasumori, Kojima Toshihisa, Funahashi Koji, Okui Nobuyuki, Mizuno Masanori, Takahashi Nobunori, Asai Shuji, Asai Nobuyuki, Matsumoto Takuya, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   81 巻 ( 3 ) 頁: 453 - 462   2019年8月

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  118. DEPRESSION IN ESTABLISHED RHEUMATOID ARTHRITIS; MULTICENTER PROSPECTIVE COHORT STUDY FOR EVALUATION OF JOINT SURGERY ON PATIENT'S REPORTED OUTCOME 査読有り Open Access

    Kojima Toshihisa, Kojima Masayo, Ishikawa Hajime, Tanaka Sakae, Nishida Keiichiro, Haga Nobuhiko, Masaoka Yukio, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Ishiguro Naoki

    ANNALS OF THE RHEUMATIC DISEASES   78 巻   頁: 2124 - 2125   2019年6月

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  119. IMPROVEMENT OF MATRIX METALLOPROTEINASE-3 AT 12 WEEKS IS AN INDEPENDENT PREDICTIVE FACTOR FOR ACHIEVEMENT OF LOW DISEASE ACTIVITY AT 52 WEEKS IN BIO-SWITCH RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ABATACEPT 査読有り Open Access

    Takahashi Nobunori, Kojima Toshihisa, Asai Shuji, Ishiguro Naoki

    ANNALS OF THE RHEUMATIC DISEASES   78 巻   頁: 728 - 729   2019年6月

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  120. DISCONTINUATION OF CONCOMITANT METHOTREXATE IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH TOCILIZUMAB: AN INTERVENTIONAL STUDY 査読有り Open Access

    Asai Shuji, Kojima Toshihisa, Takahashi Nobunori, Kuwatsuka Yachiyo, Ando Masahiko, Ishiguro Naoki

    ANNALS OF THE RHEUMATIC DISEASES   78 巻   頁: 1641 - 1641   2019年6月

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    担当区分:筆頭著者   記述言語:英語  

    DOI: 10.1136/annrheumdis-2019-eular.221

    Web of Science

  121. Association between chest computed tomography findings and respiratory adverse events in rheumatoid arthritis patients undergoing long-term biological therapy 査読有り

    Matsumoto Takuya, Iwano Shingo, Takahashi Nobunori, Asai Shuji, Watanabe Tatsuo, Asai Nobuyuki, Sobue Yasumori, Ito Satoru, Ishiguro Naoki, Kojima Toshihisa

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   22 巻 ( 4 ) 頁: 626 - 635   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/1756-185X.13434

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  122. Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis 査読有り Open Access

    Asai Shuji, Nagai Kaoru, Takahashi Nobunori, Watanabe Tatsuo, Matsumoto Takuya, Asai Nobuyuki, Sobue Yasumori, Ishiguro Naoki, Kojima Toshihisa

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   22 巻 ( 2 ) 頁: 207 - 213   2019年2月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/1756-185X.13380

    Open Access

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  123. Computed tomography evaluation of the periacetabular gap of a porous tantalum acetabular component 査読有り Open Access

    Asai Shuji, Sobue Yasumori, Asai Nobuyuki, Takahashi Nobunori, Watanabe Tatsuo, Matsumoto Takuya, Ishiguro Naoki, Kojima Toshihisa

    NAGOYA JOURNAL OF MEDICAL SCIENCE   81 巻 ( 1 ) 頁: 159 - 163   2019年2月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.18999/nagjms.81.1.159

    Open Access

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  124. Validation and reliability of the Timed Up and Go test for measuring objective functional impairment in patients with long-standing rheumatoid arthritis: a cross-sectional study 査読有り

    Kojima Toshihisa, Ishikawa Hajime, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Kojima Masayo, Ishiguro Naoki

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   21 巻 ( 10 ) 頁: 1793 - 1800   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/1756-185X.13237

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  125. Target setting for lower limb joint surgery using the Timed Up and Go test in patients with rheumatoid arthritis: A prospective cohort study 査読有り

    Kojima Toshihisa, Ishikawa Hajime, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Kojima Masayo, Ishiguro Naoki

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   21 巻 ( 10 ) 頁: 1801 - 1808   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/1756-185X.13394

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  126. Setting Treatment Target for Joint Surgery in Lower Limbs in Patients with Long-Standing Rheumatoid Arthritis Based on Multicenter Prospective Cohort Study; Validation and Reliability of Objective Index of Activity Speed (Timed Up and Go test) for Measuring Physical Function 査読有り

    Kojima Toshihisa, Ishikawa Hajime, Kojima Masayo, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   70 巻   頁: .   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  127. THE EFFECT OF METHOTREXATE ON GASTROINTESTINAL SYMPTOMS IN PATIENTS WITH RHEUMATOID ARTHRITIS 査読有り Open Access

    Asai S., Nagai K., Kojima T., Takahashi N., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   77 巻   頁: 306-307   2018年6月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/annrheumdis-2018-eular.1715

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  128. SETTING TREATMENT TARGET FOR JOINT SURGERY IN LOWER LIMBS IN PATIENTS WITH LONG-STANDING RHEUMATOID ARTHRITIS BASED ON MULTICENTER PROSPECTIVE COHORT STUDY; VALIDATION AND RELIABILITY OF OBJECTIVE INDEX OF ACTIVITY SPEED, TIMED UP AND GO TEST, FOR MEASURING PHYSICAL FUNCTION 査読有り Open Access

    Kojima T., Ishikawa H., Tanaka S., Haga N., Nishida K., Yukioka M., Hashimoto J., Miyahara H., Niki Y., Kimura T., Oda H., Funahashi K., Asai S., Kojima M., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   77 巻   頁: 1333-1334   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/annrheumdis-2018-eular.1856

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  129. INFLUENCE OF ORAL PREDNISOLONE ON EFFECT OF DENOSUMAB ON OSTEOPOROSIS IN PATIENTS WITH JAPANESE RHEUMATOID ARTHRITIS; 36 MONTHS OF FOLLOW-UP similar to A MULTICENTER REGISTRY STUDY similar to 査読有り Open Access

    Kanayama Y., Hirano Y., Takahashi N., Asai S., Ishiguro N., Kojima T.

    ANNALS OF THE RHEUMATIC DISEASES   77 巻   頁: 458-459   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/annrheumdis-2018-eular.6420

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  130. PREDICTIVE FACTORS FOR ACHIEVEMENT OF LOW DISEASE ACTIVITY AT 52 WEEKS ARE DIFFERENT BETWEEN YOUNG AND ELDERLY RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ABATACEPT 査読有り Open Access

    Takahashi N., Kojima T., Asai S., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   77 巻   頁: 326-327   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/annrheumdis-2018-eular.3382

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  131. Multicentric reticulohistiocytosis misdiagnosed as tenosynovial giant cell tumour 査読有り Open Access

    Nishida Yoshihiro, Asai Shuji, Arai Eisuke

    RHEUMATOLOGY   57 巻 ( 3 ) 頁: 461 - 461   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/rheumatology/kex312

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  132. Characteristics of functional impairment in patients with long-standing rheumatoid arthritis based on range of motion of joints: Baseline data from a multicenter prospective observational cohort study to evaluate the effectiveness of joint surgery in the treat-to-target era 査読有り Open Access

    Kojima Toshihisa, Ishikawa Hajime, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Kojima Masayo, Ishiguro Naoki

    MODERN RHEUMATOLOGY   28 巻 ( 3 ) 頁: 474 - 481   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/14397595.2017.1349593

    Open Access

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  133. Predictors of biologic discontinuation due to insufficient response in patients with rheumatoid arthritis who achieved clinical remission with biologic treatment: A multicenter observational cohort study 査読有り Open Access

    Asai Shuji, Fujibayashi Takayoshi, Oguchi Takeshi, Hanabayashi Masahiro, Hayashi Masatoshi, Matsubara Hiroyuki, Ito Takayasu, Yabe Yuichiro, Watanabe Tsuyoshi, Hirano Yuji, Kanayama Yasuhide, Kaneko Atsushi, Kato Takefumi, Takagi Hideki, Takahashi Nobunori, Funahashi Koji, Takemoto Toki, Asai Nobuyuki, Watanabe Tatsuo, Ishiguro Naoki, Kojima Toshihisa

    MODERN RHEUMATOLOGY   28 巻 ( 2 ) 頁: 221 - 226   2018年

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/14397595.2017.1332558

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  134. Influence of glucocorticoids on effect of denosumab on osteoporosis in patients with Japanese rheumatoid arthritis; 24 months of follow-up similar to a Multicenter Registry Study similar to. 査読有り

    Kanayama Yasuhide, Hirano Yuji, Takahashi Nobunori, Asai Shuji, Ishiguro Naoki, Kojima Toshihisa

    JOURNAL OF BONE AND MINERAL RESEARCH   32 巻   頁: S379-S380   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  135. Being Elderly Is Not a Predictive Factor of Discontinuation of Abatacept Due to Adverse Events in Rheumatoid Arthritis Patients with Concomitant Methotrexate: A Retrospective Observational Study Based on Data from a Japanese Multicenter Registry Study 査読有り

    Takahashi Nobunori, Kojima Toshihisa, Asai Shuji, Watanabe Tatsuo, Matsumoto Takuya, Asai Nobuyuki, Sobue Yasumori, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   69 巻   頁: .   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  136. Patient-reported outcomes as assessment tools and predictors of long-term prognosis: a 7-year follow-up study of patients with rheumatoid arthritis 査読有り Open Access

    Kojima Masayo, Kojima Toshihisa, Suzuki Sadao, Takahashi Nobunori, Funahashi Koji, Asai Shuji, Yoshioka Yutaka, Terabe Kenya, Asai Nobuyuki, Takemoto Toki, Ishiguro Naoki

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   20 巻 ( 9 ) 頁: 1193-1200   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/1756-185X.12789

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  137. TENDENCY TO CHOOSE FIRST BIOLOGIC AGENT THERAPY OF RHEUMATOID ARTHRITIS IN THE ELDERLY: RESULTS FROM JAPANESE MULTICENTER REGISTRY 査読有り Open Access

    Watanabe T., Kojima T., Takahashi N., Asai S., Asai N., Matsumoto T., Sobue Y., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   76 巻   頁: 1195-1195   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/annrheumdis-2017-eular.1679

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  138. INFLUENCE OF ORAL PREDNISOLONE ON EFFECT OF DENOSUMAB ON OSTEOPOROSIS IN PATIENTS WITH JAPANESE RHEUMATOID ARTHRITIS; 24 MONTHS OF FOLLOW-UP similar to A MULTICENTER REGISTRY STUDY similar to 査読有り Open Access

    Kanayama Y., Hirano Y., Takahashi N., Asai S., Ishiguro N., Kojima T.

    ANNALS OF THE RHEUMATIC DISEASES   76 巻   頁: 708-708   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/annrheumdis-2017-eular.4677

    Web of Science

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科研費 3

  1. 脊椎関節炎の付着部骨新生における細胞内エネルギー代謝の機能解明

    研究課題/研究課題番号:24K12371  2024年4月 - 2027年3月

    科学研究費助成事業  基盤研究(C)

    浅井 秀司, 寺部 健哉

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    担当区分:研究代表者 

    配分額:4680000円 ( 直接経費:3600000円 、 間接経費:1080000円 )

    SpAでは、腱靱帯付着部で炎症に続いて生じる骨新生が、関節可動域を制限し身体機能を大きく損なうことがある。抗サイトカイン療法を含む既存の治療は付着部骨新生を抑制する効果に乏しく、新たな治療法の開発が待たれる。
    細胞内エネルギー代謝は、細胞の分化や増殖を調整する重要な因子であり様々な刺激により変動する。本研究の目的は、SpAモデルマウスを用いて、付着部骨新生における細胞内エネルギー代謝の機能を解明することである。炎症により付着部に誘導される幹細胞を対象とした実験により、内因性幹細胞の分化をコントロールし付着部骨新生を抑制する方法の開発を目指す。

  2. 代謝リプログラミングによる腱由来間葉系幹細胞の分化制御の解明

    研究課題/研究課題番号:21K09274  2021年4月 - 2025年3月

    科学研究費助成事業  基盤研究(C)

    浅井 秀司, 寺部 健哉

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    担当区分:研究代表者 

    配分額:4030000円 ( 直接経費:3100000円 、 間接経費:930000円 )

    腱損傷部には変性と修復の両方に直接関与する特異的な間葉系幹細胞が誘導される。本研究では、この間葉系幹細胞の分化における解糖系代謝を中心とした代謝リプログラミングの機能解析を行う。また、腱損傷部の変性および修復に対する代謝リプログラミング制御の作用を明らかにする。これにより、内在性の間葉系幹細胞の分化を制御し、細胞移植を必要としない腱損傷の新たな治療法の開発につなげる。
    腱損傷部には変性と修復の両方に直接関与する特異的な間葉系幹細胞が誘導される.本研究では,この損傷腱由来間葉系幹細胞を用いて実験を行い,glycolysisを制御する物質としてヒアルロン酸に注目している.2022年度までの研究結果の概要は次の通りである.① CD1マウスの損傷腱由来間葉系幹細胞は,軟骨分化誘導によりglycolysisが亢進した.② Glycolysisを阻害する2-deoxy-D-glucose(2-DG)およびガラクトースは,損傷腱由来間葉系幹細胞の軟骨分化を抑制した.③ ヒアルロン酸は,損傷腱由来間葉系幹細胞の軟骨分化を抑制した.④ アキレス腱損傷モデルマウスにおいて,2-DGの腹腔内投与は腱損傷部の異所性骨化の体積を減少させる傾向にあった.⑤ アキレス腱損傷モデルマウスにおいて,ヒアルロン酸の局所投与は腱損傷部の異所性骨化の体積を減少させた.
    2022年度までの研究成果を踏まえ,2023年度はヒアルロン酸の軟骨分化抑制作用におけるglycolysisの関与を検討するため細胞外フラックスアナライザーにより解糖系代謝の変化を検討し,リアルタイムPCRによりglycolysis関連遺伝子(PDK-1、LDHA、GLUT1)の発現を検討した.今のところ,損傷腱由来間葉系幹細胞においてヒアルロン酸とglycolysisの関連性を示す有意な結果は得られていない.また,グルコースを添加しglycolysisを促進した損傷腱由来間葉系幹細胞において,ヒアルロン酸の軟骨分化抑制作用は減弱傾向にあったが,統計学的に有意な結果は得られてない.
    2023年度までに計画していた実験を概ね実施したが,まだ研究成果をまとめられていない.当初は2023年度に研究成果を公表する計画であったため,進捗はやや遅れている.
    これまでの研究で,glycolysisの阻害とヒアルロン酸が,それぞれ損傷腱由来間葉系幹細胞の軟骨分化を抑制し,モデルマウスの腱損傷部の異所性骨化を抑制する可能性が示された.2024年度は,2023年度に続き損傷腱由来間葉系幹細胞においてヒアルロン酸が軟骨分化を抑制する分子機構について代謝変動も含め検討する.有意な結果が得られない場合は,glycolysisによる腱由来間葉系幹細胞の分化制御を中心に研究成果をまとめ公表する予定である.

  3. ヒアルロン酸による腱由来間葉系幹細胞の分化制御の解明と腱変性予防への応用

    研究課題/研究課題番号:18K16618  2018年4月 - 2022年3月

    科学研究費助成事業  若手研究

    浅井 秀司

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    担当区分:研究代表者 

    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    腱は修復能に乏しく損傷すると元の状態まで回復することは困難であり, 加齢とともに軟骨化生や異所性骨化などの変性を生じやすくなる. 過去の研究結果をもとに, 本研究では 「ヒアルロン酸は腱損傷部に誘導される間葉系幹細胞においてヒアルロン酸レセプターCD44を介してMAPKのリン酸化を抑制し, 腱損傷後の軟骨化生を抑制するとともに腱の修復を促進する」 という仮説を立てた. 損傷腱に対するヒアルロン酸の変性予防効果と細胞内情報伝達機構を検討し以下の結果を得た.
    ① CD-1マウスのアキレス腱損傷部から単離した損傷腱由来間葉系幹細胞をmicro mass cultureにより軟骨細胞へ分化誘導し, ヒアルロン酸で処理した. アルシアンブルー染色のintegrated densityはヒアルロン酸の濃度に依存して減少した. また, 軟骨分化マーカーであるaggrecan, Sox9, II型コラーゲンの遺伝子発現量はヒアルロン酸の濃度に依存して減少した. 一方で腱分化マーカーであるMohawk, I型コラーゲンの遺伝子発現量はヒアルロン酸の濃度に依存して増加した. これらのヒアルロン酸の作用は抗CD44抗体により減弱せず, 抗CD44抗体単独でも軟骨分化マーカーの遺伝子発現量は減少した.
    ② ヒアルロン酸合成阻害剤4-メチルウンベリフェロン (4-MU) を用いて同様の実験を行った. その結果, aggrecanの遺伝子発現量はヒアルロン酸の濃度に依存して増加したが, Mohawkの遺伝子発現量に有意な変化は認められなかった. この結果は, 損傷腱由来間葉系幹細胞におけるヒアルロン酸の軟骨分化抑制作用を裏付けるものである.
    ③ In vivo実験として, アキレス腱損傷モデルマウスにヒアルロン酸の局所投与および4-MUの腹腔内投与を行っている.
    本研究では, アキレス腱損傷モデルマウスおよびそのマウスから単離した初代培養細胞を用いて実験を行っている.
    理由① 新型コロナウイルス感染拡大の影響により実験動物舎が一時使用不能となったため.
    理由② in vivoにおいて, ヒアルロン酸の粘稠度が高くマウスのアキレス腱損傷部にヒアルロン酸を局所投与する手技の確立に時間を要したため.
    2020年度までの研究により, ヒアルロン酸が損傷腱由来間葉系幹細胞の軟骨分化を抑制することが示された. さらに, CD44自体が損傷腱由来間葉系幹細胞の軟骨分化に重要な役割を果たしている可能性が示唆された. 今後は以下の実験を計画している.
    ① 現在in vivo実験で薬剤を投与しているモデルマウスの組織学的及び放射線学的評価
    ② MAPK経路を含めた損傷腱由来間葉系幹細胞におけるヒアルロン酸の細胞内情報伝達機構の検討