Updated on 2022/04/12

写真a

 
ASAI Shuji
 
Organization
Nagoya University Hospital Orthopedics Lecturer of hospital
Title
Lecturer of hospital

Degree 1

  1. 博士(医学) ( 2013.5   名古屋大学 ) 

Research Areas 1

  1. Life Science / Orthopedics

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2013.5

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 2002.3

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    Country: Japan

Professional Memberships 2

  1. 日本リウマチ学会

  2. 日本整形外科学会

 

Papers 59

  1. Effectiveness of Tacrolimus Concomitant with Biological Disease-Modifying Anti-Rheumatic Drugs in Patients with Rheumatoid Arthritis.

    Terabe K, Takahashi N, Asai S, Hirano Y, Kanayama Y, Yabe Y, Oguchi T, Fujibayashi T, Ishikawa H, Hanabayashi M, Hattori Y, Suzuki M, Kishimoto K, Ohashi Y, Imaizumi T, Imagama S, Kojima T

    Modern rheumatology     2022.3

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    Language:English  

    DOI: 10.1093/mr/roac025

    PubMed

  2. Relationship between locomotive syndrome and frailty in rheumatoid arthritis patients by locomotive syndrome stage.

    Sobue Y, Suzuki M, Ohashi Y, Koshima H, Okui N, Funahashi K, Ishikawa H, Asai S, Terabe K, Yokota Y, Kishimoto K, Takahashi N, Imagama S, Kojima T

    Modern rheumatology     2021.9

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    Language:English  

    DOI: 10.1093/mr/roab024

    PubMed

  3. Depression, physical function, and disease activity associated with frailty in patients with rheumatoid arthritis

    Kojima Masayo, Kojima Toshihisa, Waguri-Nagaya Yuko, Takahashi Nobunori, Asai Shuji, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Mitsui Hiroto, Kawaguchi Yohei, Kuroyanagi Gen, Yasuoka Mikako, Watanabe Miki, Suzuki Sadao, Arai Hidenori

    MODERN RHEUMATOLOGY   Vol. 31 ( 5 ) page: 979 - 986   2021.9

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  4. Impact of social support on severity of depressive symptoms by remission status in patients with rheumatoid arthritis.

    Yasuoka M, Kojima T, Waguri-Nagaya Y, Saito T, Takahashi N, Asai S, Sobue Y, Nishiume T, Suzuki M, Mitsui H, Kawaguchi Y, Kuroyanagi G, Kamiji K, Watanabe M, Suzuki S, Kondo K, Ojima T, Kojima M

    Modern rheumatology     2021.8

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    Language:English  

    DOI: 10.1093/mr/roab001

    PubMed

  5. Comparison of the effects of baricitinib and tocilizumab on disease activity in patients with rheumatoid arthritis: a propensity score matching analysis

    Asai Shuji, Takahashi Nobunori, Kobayakawa Tomonori, Kaneko Atsushi, Watanabe Tatsuo, Kato Takefumi, Nishiume Tsuyoshi, Ishikawa Hisato, Yoshioka Yutaka, Kanayama Yasuhide, Watanabe Tsuyoshi, Hirano Yuji, Hanabayashi Masahiro, Yabe Yuichiro, Yokota Yutaka, Suzuki Mochihito, Terabe Kenya, Ishiguro Naoki, Imagama Shiro, Kojima Toshihisa

    CLINICAL RHEUMATOLOGY   Vol. 40 ( 8 ) page: 3143 - 3151   2021.8

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  6. Higher doses of methotrexate associated with discontinuation of oral glucocorticoids after initiation of biological DMARDs: A retrospective observational study based on data from a Japanese multicenter registry study

    Suzuki Mochihito, Kojima Toshihisa, Takahashi Nobunori, Asai Shuji, Terabe Kenya, Kaneko Atsushi, Hirano Yuji, Hanabayashi Masahiro, Oguchi Takeshi, Takagi Hideki, Kanayama Yasuhide, Yabe Yuichiro, Funahashi Koji, Fujibayashi Takayoshi, Tsuboi Seiji, Ito Takayasu, Yoshioka Yutaka, Ishikawa Hisato, Sobue Yasumori, Nishiume Tsuyoshi, Yokota Yutaka, Ishiguro Naoki

    MODERN RHEUMATOLOGY   Vol. 31 ( 4 ) page: 796 - 802   2021.7

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  7. REASONS AND RISK FACTOR FOR DISCONTINUATION OF BIOLOGIC AGENTS FOR RHEUMATOID ARTHRITIS PATIENTS IN LONG-TERM OBSERVATION

    Terabe K., Takahashi N., Asai S., Hirano Y., Kanayama Y., Kojima T.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 80   page: 1142 - 1143   2021.6

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  8. Fifteen-year trends in the number and age of patients with rheumatoid arthritis undergoing total knee and hip arthroplasty: A comparison study with osteoarthritis

    Asai Shuji, Takemoto Toki, Takahashi Nobunori, Oguchi Takeshi, Ishiguro Naoki, Kojima Toshihisa

    MODERN RHEUMATOLOGY   Vol. 31 ( 3 ) page: 768 - 771   2021.5

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  9. Relationship between the physician-based clinical scale for foot and ankle surgery and patient-reported outcomes in patients with long-standing rheumatoid arthritis: Results from a multicenter prospective observational cohort study

    Kojima Toshihisa, Ishikawa Hajime, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Kojima Masayo, Ishiguro Naoki

    MODERN RHEUMATOLOGY   Vol. 31 ( 3 ) page: 607 - 613   2021.5

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  10. Relationship between disease activity of rheumatoid arthritis and development of locomotive syndrome: A five-year longitudinal cohort study

    Sobue Yasumori, Kojima Toshihisa, Funahashi Koji, Okui Nobuyuki, Takahashi Nobunori, Asai Shuji, Terabe Kenya, Nishiume Tsuyoshi, Suzuki Mochihito, Yokota Yutaka, Ohashi Yoshifumi, Ishiguro Naoki

    MODERN RHEUMATOLOGY   Vol. 31 ( 1 ) page: 101 - 107   2021.1

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  11. Predictors for clinical effectiveness of baricitinib in rheumatoid arthritis patients in routine clinical practice: data from a Japanese multicenter registry

    Takahashi Nobunori, Asai Shuji, Kobayakawa Tomonori, Kaneko Atsushi, Watanabe Tatsuo, Kato Takefumi, Nishiume Tsuyoshi, Ishikawa Hisato, Yoshioka Yutaka, Kanayama Yasuhide, Watanabe Tsuyoshi, Hirano Yuji, Hanabayashi Masahiro, Yabe Yuichiro, Yokota Yutaka, Suzuki Mochihito, Sobue Yasumori, Terabe Kenya, Ishiguro Naoki, Kojima Toshihisa

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 21907   2020.12

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  12. Predictors of disease flare after discontinuation of concomitant methotrexate in Japanese patients with rheumatoid arthritis treated with tocilizumab

    Asai Shuji, Takahashi Nobunori, Hayashi Masatoshi, Hanabayashi Masahiro, Kanayama Yasuhide, Takemoto Toki, Yabe Yuichiro, Shioura Tomone, Ishikawa Hisato, Yoshioka Yutaka, Kato Takefumi, Hirano Yuji, Fujibayashi Takayoshi, Hattori Yosuke, Kobayakawa Tomonori, Ando Masahiko, Kuwatsuka Yachiyo, Matsumoto Takuya, Asai Nobuyuki, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki, Kojima Toshihisa

    JOINT BONE SPINE   Vol. 87 ( 6 ) page: 596 - 602   2020.12

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  13. A retrospective analysis of the relationship between anti-cyclic citrullinated peptide antibody and the effectiveness of abatacept in rheumatoid arthritis patients

    Kida Daihei, Takahashi Nobunori, Kaneko Atsushi, Hirano Yuji, Fujibayashi Takayoshi, Kanayama Yasuhide, Hanabayashi Masahiro, Yabe Yuichiro, Takagi Hideki, Oguchi Takeshi, Kato Takefumi, Funahashi Koji, Matsumoto Takuya, Ando Masahiko, Kuwatsuka Yachiyo, Tanaka Eiichi, Yasuoka Hidekata, Kaneko Yuko, Hirata Shintaro, Murakami Kosaku, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Yokota Yutaka, Terabe Kenya, Asai Shuji, Ishiguro Naoki, Kojima Toshihisa

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 19717   2020.11

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  14. Periarticular osteophyte formation protects against total knee arthroplasty in rheumatoid arthritis patients with advanced joint damage

    Asai Shuji, Takahashi Nobunori, Terabe Kenya, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Yokota Yutaka, Ishiguro Naoki, Kojima Toshihisa

    CLINICAL RHEUMATOLOGY   Vol. 39 ( 11 ) page: 3331 - 3339   2020.11

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  15. Factors associated with osteophyte formation in patients with rheumatoid arthritis undergoing total knee arthroplasty

    Asai Nobuyuki, Asai Shuji, Takahashi Nobunori, Ishiguro Naoki, Kojima Toshihisa

    MODERN RHEUMATOLOGY   Vol. 30 ( 5 ) page: 937 - 939   2020.9

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  16. Improvement in matrix metalloproteinase-3 independently predicts low disease activity at 52 weeks in bio-switch rheumatoid arthritis patients treated with abatacept.

    Takemoto T, Takahashi N, Kida D, Kaneko A, Hirano Y, Fujibayashi T, Kanayama Y, Hanabayashi M, Yabe Y, Takagi H, Oguchi T, Kato T, Funahashi K, Matsumoto T, Sobue Y, Nishiume T, Suzuki M, Yokota Y, Terabe K, Asai S, Ishiguro N, Kojima T

    Clinical and experimental rheumatology   Vol. 38 ( 5 ) page: 933 - 939   2020.9

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    Language:English  

    PubMed

  17. Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: A 14-year trend analysis (2004-2017)

    Asai Shuji, Takahashi Nobunori, Asai Nobuyuki, Yamashita Satoshi, Terabe Kenya, Matsumoto Takuya, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki, Kojima Toshihisa

    MODERN RHEUMATOLOGY   Vol. 30 ( 4 ) page: 657 - 663   2020.7

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  18. COMPARATIVE STUDY OF PATIENT BACKGROUND AND TREATMENT OUTCOME BY BARICITINIB DOSE UNDER REAL CLINICAL CONDITIONS.

    Nishiume T., Takahashi N., Kojima T., Asai S., Terabe K., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 79   page: 1472 - 1473   2020.6

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  19. THE EFFECTIVENESS OF BIOLOGICAL AGENTS CONCOMITANT WITH TACROLIMUS IN RHEUMATOID ARTHRITIS

    Terabe K., Takahashi N., Asai S., Kaneko A., Hirano Y., Kanayama Y., Yabe Y., Kojima T., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 79   page: 304 - 305   2020.6

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  20. PREDICTORS OF DISEASE FLARE AFTER DISCONTINUATION OF CONCOMITANT METHOTREXATE IN JAPANESE PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH TOCILIZUMAB

    Asai S., Takahashi N., Kuwatsuka Y., Ando M., Ishiguro N., Kojima T.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 79   page: 252 - 253   2020.6

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  21. PREDICTORS FOR SHORT-TERM CLINICAL EFFECTIVENESS OF BARICITINIB IN RHEUMATOID ARTHRITIS PATIENTS IN ROUTINE CLINICAL PRACTICE: DATA FROM A JAPANESE MULTICENTER REGISTRY

    Takahashi N., Kojima T., Asai S., Terabe K., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 79   page: 646 - 646   2020.6

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  22. PERIARTICULAR OSTEOPHYTE FORMATION PROTECTS AGAINST TOTAL KNEE ARTHROPLASTY IN RHEUMATOID ARTHRITIS PATIENTS WITH ADVANCED JOINT DAMAGE

    Asai S., Takahashi N., Terabe K., Kojima T., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 79   page: 1384 - 1385   2020.6

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  23. IMPROVEMENT OF DEPRESSION BY JOINT SURGERY IN ESTABLISHED RHEUMATOID ARTHRITIS; RESULTS FROM MULTICENTER PROSPECTIVE COHORT STUDY FOR EVALUATION OF JOINT SURGERY ON PATIENT'S REPORTED OUTCOME

    Kojima T., Kojima M., Ishikawa H., Nishida K., Asai S., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 79   page: 1872 - 1873   2020.6

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  24. HIGHER DOSES OF METHOTREXATE ASSOCIATED WITH DISCONTINUATION OF ORAL GLUCOCORTICOIDS AFTER INITIATION OF BIOLOGICAL DMARDS: A RETROSPECTIVE OBSERVATIONAL STUDY BASED ON DATA FROM A JAPANESE MULTICENTER REGISTRY STUDY

    Suzuki M., Kojima T., Takahashi N., Asai S., Terabe K., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 79   page: 991 - 992   2020.6

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  25. EFFECTIVENESS OF ABATACEPT ON CLINICAL DISEASE ACTIVITY AND RADIOGRAPHIC PROGRESSION IN RHEUMATOID ARTHRITIS PATIENTS IN DAILY CLINICAL PRACTICE IN JAPAN: COMPARISONS ACCORDING TO ACPA STATUS

    Takahashi N., Kojima T., Asai S., Terabe K., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 79   page: 629 - 630   2020.6

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  26. Discontinuation of concomitant methotrexate in Japanese patients with rheumatoid arthritis treated with tocilizumab: An interventional study

    Asai Shuji, Hayashi Masatoshi, Hanabayashi Masahiro, Kanayama Yasuhide, Takemoto Toki, Yabe Yuichiro, Shioura Tomone, Ishikawa Hisato, Yoshioka Yutaka, Kato Takefumi, Hirano Yuji, Fujibayashi Takayoshi, Hattori Yosuke, Kobayakawa Tomonori, Ando Masahiko, Kuwatsuka Yachiyo, Takahashi Nobunori, Matsumoto Takuya, Asai Nobuyuki, Sobue Yasumori, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki, Kojima Toshihisa

    MODERN RHEUMATOLOGY   Vol. 30 ( 3 ) page: 434 - 441   2020.5

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  27. Targetable driver mutations in multicentric reticulohistiocytosis

    Murakami Norihiro, Sakai Tomohisa, Arai Eisuke, Muramatsu Hideki, Ichikawa Daisuke, Asai Shuji, Shimoyama Yoshie, Ishiguro Naoki, Takahashi Yoshiyuki, Okuno Yusuke, Nishida Yoshihiro

    HAEMATOLOGICA   Vol. 105 ( 2 ) page: E61 - E64   2020.1

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  28. Improvement in matrix metalloproteinase-3 independently predicts low disease activity at 52 weeks in bio-switch rheumatoid arthritis patients treated with abatacept

    Takemoto T., Takahashi N., Kida D., Kaneko A., Hirano Y., Fujibayashi T., Kanayama Y., Hanabayashi M., Yabe Y., Takagi H., Oguchi T., Kato T., Funahashi K., Matsumoto T., Sobue Y., Nishiume T., Suzuki M., Yokota Y., Terabe K., Asai S., Ishiguro N., Kojima T.

    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY   Vol. 38 ( 5 ) page: 933 - 939   2020

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    Language:Japanese  

    Web of Science

  29. Clinical effectiveness and safety of additional administration of tacrolimus in rheumatoid arthritis patients with an inadequate response to abatacept: A retrospective cohort study

    Suzuki Mochihito, Takahashi Nobunori, Kida Daihei, Hirano Yuji, Kato Takefumi, Yabe Yuichiro, Oguchi Takeshi, Fujibayashi Takayoshi, Hayashi Masatoshi, Asai Shuji, Ishiguro Naoki, Kojima Toshihisa

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   Vol. 22 ( 12 ) page: 2199 - 2205   2019.12

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  30. Clinical effectiveness and long-term retention of abatacept in elderly rheumatoid arthritis patients: Results from a multicenter registry system.

    Takahashi N, Kojima T, Kida D, Kaneko A, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Hanabayashi M, Kato T, Funahashi K, Hayashi M, Tsuboi S, Kanayama Y, Sobue Y, Asai N, Matsumoto T, Watanabe T, Asai S, Ishiguro N

    Modern rheumatology   Vol. 29 ( 6 ) page: 910 - 918   2019.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14397595.2018.1525019

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  31. Association between seropositivity and discontinuation of tumor necrosis factor inhibitors due to ineffectiveness in rheumatoid arthritis

    Ogawa Yoshikazu, Takahashi Nobunori, Kaneko Atsushi, Hirano Yuji, Kanayama Yasuhide, Yabe Yuichiro, Oguchi Takeshi, Fujibayashi Takayoshi, Takagi Hideki, Hanabayashi Masahiro, Funahashi Koji, Hayashi Masatoshi, Tsuboi Seiji, Asai Shuji, Asai Nobuyuki, Matsumoto Takuya, Sobue Yasumori, Ishiguro Naoki, Kojima Toshihisa

    CLINICAL RHEUMATOLOGY   Vol. 38 ( 10 ) page: 2757 - 2763   2019.10

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  32. Improving Depression by Joint Surgery in Established Rheumatoid Arthritis; Results from Multicenter Prospective Cohort Study for Evaluation of Joint Surgery on Patient's Reported Outcome

    Kojima Toshihisa, Kojima Masayo, Ishikawa Hajime, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   Vol. 71   2019.10

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    Language:Japanese  

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  33. Improvement in Matrix metalloproteinase-3 Levels at 12 Weeks Independently Predicts Achievement of Low Disease Activity at 52 Weeks in Bio-switch Patients with Rheumatoid Arthritis Treated with Abatacept

    Takahashi Nobunori, Kojima Toshihisa, Terabe Kenya, Asai Shuji, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   Vol. 71   2019.10

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    Language:Japanese  

    Web of Science

  34. Discontinuation of Oral Glucocorticoid After Initiation of Biological DMARDs Due to a Higher Dose of Methotrexate; A Retrospective Observational Study Based on Data from a Japanese Multicenter Registry Study

    Suzuki Mochihito, Kojima Toshihisa, Takahashi Nobunori, Asai Shuji, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   Vol. 71   2019.10

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    Language:Japanese  

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  35. Discontinuation of Concomitant Methotrexate in Japanese Patients with Rheumatoid Arthritis Treated with Tocilizumab: An Interventional Study

    Kojima Toshihisa, Asai Shuji, Hanabayashi Masahiro, Hayashi Masatoshi, Takahashi Nobunori, Kuwatsuka Yachiyo, Ando Masahiko, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   Vol. 71   2019.10

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    Language:Japanese  

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  36. Characteristics of Patients with Rheumatoid Arthritis Undergoing Primary Total Joint Replacement: A 14-year Trend Analysis (2004-2017)

    Asai Shuji, Kojima Toshihisa, Takahashi Nobunori, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   Vol. 71   2019.10

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    Language:Japanese  

    Web of Science

  37. Concomitant methotrexate has little effect on clinical outcomes of abatacept in rheumatoid arthritis: a propensity score matching analysis

    Takahashi Nobunori, Kojima Toshihisa, Kida Daihei, Kaneko Atsushi, Hirano Yuji, Fujibayashi Takayoshi, Yabe Yuichiro, Takagi Hideki, Oguchi Takeshi, Hanabayashi Masahiro, Kato Takefumi, Funahashi Koji, Hayashi Masatoshi, Tsuboi Seiji, Kanayama Yasuhide, Sobue Yasumori, Asai Nobuyuki, Matsumoto Takuya, Watanabe Tatsuo, Asai Shuji, Ishiguro Naoki

    CLINICAL RHEUMATOLOGY   Vol. 38 ( 9 ) page: 2451 - 2459   2019.9

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  38. Relationship between rheumatoid arthritis and locomotive syndrome: validation of the 25-question Geriatric Locomotive Function Scale in patients with rheumatoid arthritis

    Sobue Yasumori, Kojima Toshihisa, Funahashi Koji, Okui Nobuyuki, Mizuno Masanori, Takahashi Nobunori, Asai Shuji, Asai Nobuyuki, Matsumoto Takuya, Nishiume Tsuyoshi, Suzuki Mochihito, Ishiguro Naoki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 3 ) page: 453 - 462   2019.8

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  39. DEPRESSION IN ESTABLISHED RHEUMATOID ARTHRITIS; MULTICENTER PROSPECTIVE COHORT STUDY FOR EVALUATION OF JOINT SURGERY ON PATIENT'S REPORTED OUTCOME

    Kojima Toshihisa, Kojima Masayo, Ishikawa Hajime, Tanaka Sakae, Nishida Keiichiro, Haga Nobuhiko, Masaoka Yukio, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Ishiguro Naoki

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 78   page: 2124 - 2125   2019.6

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  40. IMPROVEMENT OF MATRIX METALLOPROTEINASE-3 AT 12 WEEKS IS AN INDEPENDENT PREDICTIVE FACTOR FOR ACHIEVEMENT OF LOW DISEASE ACTIVITY AT 52 WEEKS IN BIO-SWITCH RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ABATACEPT

    Takahashi Nobunori, Kojima Toshihisa, Asai Shuji, Ishiguro Naoki

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 78   page: 728 - 729   2019.6

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  41. DISCONTINUATION OF CONCOMITANT METHOTREXATE IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH TOCILIZUMAB: AN INTERVENTIONAL STUDY

    Asai Shuji, Kojima Toshihisa, Takahashi Nobunori, Kuwatsuka Yachiyo, Ando Masahiko, Ishiguro Naoki

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 78   page: 1641 - 1641   2019.6

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  42. Association between chest computed tomography findings and respiratory adverse events in rheumatoid arthritis patients undergoing long-term biological therapy.

    Matsumoto T, Iwano S, Takahashi N, Asai S, Watanabe T, Asai N, Sobue Y, Ito S, Ishiguro N, Kojima T

    International journal of rheumatic diseases   Vol. 22 ( 4 ) page: 626 - 635   2019.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1756-185X.13434

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  43. Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis.

    Asai S, Nagai K, Takahashi N, Watanabe T, Matsumoto T, Asai N, Sobue Y, Ishiguro N, Kojima T

    International journal of rheumatic diseases   Vol. 22 ( 2 ) page: 207 - 213   2019.2

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    DOI: 10.1111/1756-185X.13380

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  44. Computed tomography evaluation of the periacetabular gap of a porous tantalum acetabular component

    Asai Shuji, Sobue Yasumori, Asai Nobuyuki, Takahashi Nobunori, Watanabe Tatsuo, Matsumoto Takuya, Ishiguro Naoki, Kojima Toshihisa

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 1 ) page: 159 - 163   2019.2

  45. Validation and reliability of the Timed Up and Go test for measuring objective functional impairment in patients with long-standing rheumatoid arthritis: a cross-sectional study.

    Kojima T, Ishikawa H, Tanaka S, Haga N, Nishida K, Yukioka M, Hashimoto J, Miyahara H, Niki Y, Kimura T, Oda H, Asai S, Funahashi K, Kojima M, Ishiguro N

    International journal of rheumatic diseases   Vol. 21 ( 10 ) page: 1793 - 1800   2018.10

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    DOI: 10.1111/1756-185X.13237

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  46. Target setting for lower limb joint surgery using the Timed Up and Go test in patients with rheumatoid arthritis: A prospective cohort study

    Kojima Toshihisa, Ishikawa Hajime, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Kojima Masayo, Ishiguro Naoki

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   Vol. 21 ( 10 ) page: 1801 - 1808   2018.10

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    DOI: 10.1111/1756-185X.13394

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  47. Setting Treatment Target for Joint Surgery in Lower Limbs in Patients with Long-Standing Rheumatoid Arthritis Based on Multicenter Prospective Cohort Study; Validation and Reliability of Objective Index of Activity Speed (Timed Up and Go test) for Measuring Physical Function

    Kojima Toshihisa, Ishikawa Hajime, Kojima Masayo, Tanaka Sakae, Haga Nobuhiko, Nishida Keiichiro, Yukioka Masao, Hashimoto Jun, Miyahara Hisaaki, Niki Yasuo, Kimura Tomoatsu, Oda Hiromi, Asai Shuji, Funahashi Koji, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   Vol. 70   page: .   2018.9

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  48. SETTING TREATMENT TARGET FOR JOINT SURGERY IN LOWER LIMBS IN PATIENTS WITH LONG-STANDING RHEUMATOID ARTHRITIS BASED ON MULTICENTER PROSPECTIVE COHORT STUDY; VALIDATION AND RELIABILITY OF OBJECTIVE INDEX OF ACTIVITY SPEED, TIMED UP AND GO TEST, FOR MEASURING PHYSICAL FUNCTION

    Kojima T., Ishikawa H., Tanaka S., Haga N., Nishida K., Yukioka M., Hashimoto J., Miyahara H., Niki Y., Kimura T., Oda H., Funahashi K., Asai S., Kojima M., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 77   page: 1333-1334   2018.6

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    DOI: 10.1136/annrheumdis-2018-eular.1856

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  49. PREDICTIVE FACTORS FOR ACHIEVEMENT OF LOW DISEASE ACTIVITY AT 52 WEEKS ARE DIFFERENT BETWEEN YOUNG AND ELDERLY RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ABATACEPT

    Takahashi N., Kojima T., Asai S., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 77   page: 326-327   2018.6

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    DOI: 10.1136/annrheumdis-2018-eular.3382

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  50. INFLUENCE OF ORAL PREDNISOLONE ON EFFECT OF DENOSUMAB ON OSTEOPOROSIS IN PATIENTS WITH JAPANESE RHEUMATOID ARTHRITIS; 36 MONTHS OF FOLLOW-UP similar to A MULTICENTER REGISTRY STUDY similar to

    Kanayama Y., Hirano Y., Takahashi N., Asai S., Ishiguro N., Kojima T.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 77   page: 458-459   2018.6

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    DOI: 10.1136/annrheumdis-2018-eular.6420

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  51. THE EFFECT OF METHOTREXATE ON GASTROINTESTINAL SYMPTOMS IN PATIENTS WITH RHEUMATOID ARTHRITIS

    Asai S., Nagai K., Kojima T., Takahashi N., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 77   page: 306-307   2018.6

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    DOI: 10.1136/annrheumdis-2018-eular.1715

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  52. Multicentric reticulohistiocytosis misdiagnosed as tenosynovial giant cell tumour.

    Nishida Y, Asai S, Arai E

    Rheumatology (Oxford, England)   Vol. 57 ( 3 ) page: 461 - 461   2018.3

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    DOI: 10.1093/rheumatology/kex312

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  53. Characteristics of functional impairment in patients with long-standing rheumatoid arthritis based on range of motion of joints: Baseline data from a multicenter prospective observational cohort study to evaluate the effectiveness of joint surgery in the treat-to-target era.

    Kojima T, Ishikawa H, Tanaka S, Haga N, Nishida K, Yukioka M, Hashimoto J, Miyahara H, Niki Y, Kimura T, Oda H, Asai S, Funahashi K, Kojima M, Ishiguro N

    Modern rheumatology   Vol. 28 ( 3 ) page: 474 - 481   2018

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    DOI: 10.1080/14397595.2017.1349593

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  54. Predictors of biologic discontinuation due to insufficient response in patients with rheumatoid arthritis who achieved clinical remission with biologic treatment: A multicenter observational cohort study.

    Asai S, Fujibayashi T, Oguchi T, Hanabayashi M, Hayashi M, Matsubara H, Ito T, Yabe Y, Watanabe T, Hirano Y, Kanayama Y, Kaneko A, Kato T, Takagi H, Takahashi N, Funahashi K, Takemoto T, Asai N, Watanabe T, Ishiguro N, Kojima T

    Modern rheumatology   Vol. 28 ( 2 ) page: 221 - 226   2018

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    DOI: 10.1080/14397595.2017.1332558

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  55. Influence of glucocorticoids on effect of denosumab on osteoporosis in patients with Japanese rheumatoid arthritis; 24 months of follow-up similar to a Multicenter Registry Study similar to.

    Kanayama Yasuhide, Hirano Yuji, Takahashi Nobunori, Asai Shuji, Ishiguro Naoki, Kojima Toshihisa

    JOURNAL OF BONE AND MINERAL RESEARCH   Vol. 32   page: S379-S380   2017.12

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  56. Being Elderly Is Not a Predictive Factor of Discontinuation of Abatacept Due to Adverse Events in Rheumatoid Arthritis Patients with Concomitant Methotrexate: A Retrospective Observational Study Based on Data from a Japanese Multicenter Registry Study

    Takahashi Nobunori, Kojima Toshihisa, Asai Shuji, Watanabe Tatsuo, Matsumoto Takuya, Asai Nobuyuki, Sobue Yasumori, Ishiguro Naoki

    ARTHRITIS & RHEUMATOLOGY   Vol. 69   page: .   2017.10

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  57. Patient-reported outcomes as assessment tools and predictors of long-term prognosis: a 7-year follow-up study of patients with rheumatoid arthritis

    Kojima Masayo, Kojima Toshihisa, Suzuki Sadao, Takahashi Nobunori, Funahashi Koji, Asai Shuji, Yoshioka Yutaka, Terabe Kenya, Asai Nobuyuki, Takemoto Toki, Ishiguro Naoki

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   Vol. 20 ( 9 ) page: 1193-1200   2017.9

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    DOI: 10.1111/1756-185X.12789

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  58. INFLUENCE OF ORAL PREDNISOLONE ON EFFECT OF DENOSUMAB ON OSTEOPOROSIS IN PATIENTS WITH JAPANESE RHEUMATOID ARTHRITIS; 24 MONTHS OF FOLLOW-UP similar to A MULTICENTER REGISTRY STUDY similar to

    Kanayama Y., Hirano Y., Takahashi N., Asai S., Ishiguro N., Kojima T.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 76   page: 708-708   2017.6

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    DOI: 10.1136/annrheumdis-2017-eular.4677

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  59. TENDENCY TO CHOOSE FIRST BIOLOGIC AGENT THERAPY OF RHEUMATOID ARTHRITIS IN THE ELDERLY: RESULTS FROM JAPANESE MULTICENTER REGISTRY

    Watanabe T., Kojima T., Takahashi N., Asai S., Asai N., Matsumoto T., Sobue Y., Ishiguro N.

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 76   page: 1195-1195   2017.6

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    DOI: 10.1136/annrheumdis-2017-eular.1679

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KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. 代謝リプログラミングによる腱由来間葉系幹細胞の分化制御の解明

    Grant number:21K09274  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    浅井 秀司, 寺部 健哉

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    Authorship:Principal investigator 

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    腱損傷部には変性と修復の両方に直接関与する特異的な間葉系幹細胞が誘導される。本研究では、この間葉系幹細胞の分化における解糖系代謝を中心とした代謝リプログラミングの機能解析を行う。また、腱損傷部の変性および修復に対する代謝リプログラミング制御の作用を明らかにする。これにより、内在性の間葉系幹細胞の分化を制御し、細胞移植を必要としない腱損傷の新たな治療法の開発につなげる。

  2. ヒアルロン酸による腱由来間葉系幹細胞の分化制御の解明と腱変性予防への応用

    Grant number:18K16618  2018.4 - 2022.3

    科学研究費助成事業  若手研究

    浅井 秀司

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    腱は修復能に乏しく損傷すると元の状態まで回復することは困難であり, 加齢とともに軟骨化生や異所性骨化などの変性を生じやすくなる. 過去の研究結果をもとに, 本研究では 「ヒアルロン酸は腱損傷部に誘導される間葉系幹細胞においてヒアルロン酸レセプターCD44を介してMAPKのリン酸化を抑制し, 腱損傷後の軟骨化生を抑制するとともに腱の修復を促進する」 という仮説を立てた. 損傷腱に対するヒアルロン酸の変性予防効果と細胞内情報伝達機構を検討し以下の結果を得た.
    ① CD-1マウスのアキレス腱損傷部から単離した損傷腱由来間葉系幹細胞をmicro mass cultureにより軟骨細胞へ分化誘導し, ヒアルロン酸で処理した. アルシアンブルー染色のintegrated densityはヒアルロン酸の濃度に依存して減少した. また, 軟骨分化マーカーであるaggrecan, Sox9, II型コラーゲンの遺伝子発現量はヒアルロン酸の濃度に依存して減少した. 一方で腱分化マーカーであるMohawk, I型コラーゲンの遺伝子発現量はヒアルロン酸の濃度に依存して増加した. これらのヒアルロン酸の作用は抗CD44抗体により減弱せず, 抗CD44抗体単独でも軟骨分化マーカーの遺伝子発現量は減少した.
    ② ヒアルロン酸合成阻害剤4-メチルウンベリフェロン (4-MU) を用いて同様の実験を行った. その結果, aggrecanの遺伝子発現量はヒアルロン酸の濃度に依存して増加したが, Mohawkの遺伝子発現量に有意な変化は認められなかった. この結果は, 損傷腱由来間葉系幹細胞におけるヒアルロン酸の軟骨分化抑制作用を裏付けるものである.
    ③ In vivo実験として, アキレス腱損傷モデルマウスにヒアルロン酸の局所投与および4-MUの腹腔内投与を行っている.
    本研究では, アキレス腱損傷モデルマウスおよびそのマウスから単離した初代培養細胞を用いて実験を行っている.
    理由① 新型コロナウイルス感染拡大の影響により実験動物舎が一時使用不能となったため.
    理由② in vivoにおいて, ヒアルロン酸の粘稠度が高くマウスのアキレス腱損傷部にヒアルロン酸を局所投与する手技の確立に時間を要したため.
    2020年度までの研究により, ヒアルロン酸が損傷腱由来間葉系幹細胞の軟骨分化を抑制することが示された. さらに, CD44自体が損傷腱由来間葉系幹細胞の軟骨分化に重要な役割を果たしている可能性が示唆された. 今後は以下の実験を計画している.
    ① 現在in vivo実験で薬剤を投与しているモデルマウスの組織学的及び放射線学的評価
    ② MAPK経路を含めた損傷腱由来間葉系幹細胞におけるヒアルロン酸の細胞内情報伝達機構の検討