Updated on 2024/11/01

写真a

 
SAKUMA Koya
 
Organization
Cellular and Structural Physiology Institute Division Assistant Professor
Title
Assistant Professor
 

Papers 3

  1. Dual-wield NTPases: A novel protein family mined from AlphaFold DB Reviewed

    Sakuma, K; Koike, R; Ota, M

    PROTEIN SCIENCE   Vol. 33 ( 4 ) page： e4934   2024.3

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Protein Science  

    AlphaFold protein structure database (AlphaFold DB) archives a vast number of predicted models. We conducted systematic data mining against AlphaFold DB and discovered an uncharacterized P-loop NTPase family. The structure of the protein family was surprisingly novel, showing an atypical topology for P-loop NTPases, noticeable twofold symmetry, and two pairs of independent putative active sites. Our findings show that structural data mining is a powerful approach to identifying undiscovered protein families.

    DOI： 10.1002/pro.4934

    Web of Science

    Scopus

    PubMed

  2. Design of complicated all-α protein structures Reviewed

    Sakuma, K., Kobayashi, N., Sugiki, T. et al.

    Nature Structural & Molecular Biology   Vol. 31 ( 2 ) page： 275 - 282   2024.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1038/s41594-023-01147-9

    DOI： 10.1038/s41594-023-01147-9

  3. How AlphaFold2 Predicts Conditionally Folding Regions Annotated in an Intrinsically Disordered Protein Database, IDEAL Reviewed

    Hiroto Anbo, Koya Sakuma, Satoshi Fukuchi, Motonori Ota

    Biology   Vol. 12 ( 2 ) page： 182   2023.1

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Books 1

  1. Generative models for proteins in post-AlphaFold era make computational protein design accessible to all

    （ Role： Joint author）

    2023.9  （ ISBN:978-4-7581-2572-7 ）

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    Total pages：7   Responsible for pages：7   Language：Japanese Book type：Textbook, survey, introduction

    DOI： 10.18958/7335-00001-0000603-00

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