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出版者・発行元：Journal of Translational Medicine  

DOI： 10.1186/s12967-025-06145-7

Open Access

Web of Science

Scopus

PubMed

出版者・発行元：Nagoya Journal of Medical Science  

The number of individuals with age-related mild cognitive impairment and subsequent dementia has inevitably increased with the rise in population aging. It is important to maintain cognitive function or decelerate declines in cognitive function. However, the evidence on lifestyle-based factors associated with this decline is lacking. Here, we investigated modifiable lifestyle-based factors associated with chronological cognitive decline in cognitively healthy adults aged ≥60 years (Mini-Mental State Examination [MMSE] score ≥27). This case-control study enrolled 363 participants who were divided into two groups based on annual declines in MMSE score: 40 cases with an MMSE score decline of ≥0.5 points/year and 323 controls with maintained MMSE scores. Smoking, lower social functioning scores on the 36-Item Short Form Health Survey version 2, higher Pittsburgh Sleep Quality Index (PSQI) global scores, and sleep disorders were significantly associated with a decline in MMSE scores. Multivariate logistic regression analysis revealed higher age, current smoking status, and either higher PSQI global scores or sleep disorders to be independently associated with MMSE score decline. In conclusion, the present study identified aging, smoking, and sleep quality as factors associated with a greater decline in MMSE scores in cognitively healthy individuals. Our findings highlight the potential importance of lifestyle factors in preventing cognitive decline.

DOI： 10.18999/nagjms.87.1.105

Open Access

Web of Science

Scopus

記述言語：英語   出版者・発行元：公益社団法人 日本薬学会  

With the increase in life expectancy in Japan, the proportion of older adults requiring medical assistance continues to increase. Hence, the Japanese government proposed the establishment of a community-based integrated care system, aimed at ensuring housing, medical care, long-term care, prevention, and lifestyle support in a comprehensive manner by 2025. To achieve this paradigm shift, pharmacies must collaborate with their respective medical providers. Therefore, we conducted a questionnaire survey to investigate the characteristics of pharmacies with successful regional medical collaborations. An original questionnaire was sent to 1200 randomly sampled pharmacies in Tokyo, of which 350 (29.2%) responded. These were evaluated based on the implementation of regional medical collaboration. The adequacy of a regional medical collaboration system was positively related to the operational structure (e.g., staffing and information sharing within the pharmacy) and the number of hospitals (including clinics) issuing prescriptions. In addition, insufficient personnel and a lack of interaction with other medical providers were identified as major obstacles to implementing regional collaboration. Notably, the geographic distance from medical providers and the type of division of labor with medical providers were not associated with the adequacy of engagement in a regional medical collaboration system. The results of this study suggest that it may be possible to move closer to the realization of a community-based integrated care system through communication with other healthcare professionals and appropriate staffing regardless of the pharmacy’s business form.

DOI： 10.1248/bpb.b24-00316

Open Access

Web of Science

Scopus

PubMed

CiNii Research

記述言語：英語  

DOI： 10.1002/ccr3.9368

Open Access

Web of Science

PubMed

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/biomedicines12020300

開催年月日： 2024年2月 - 2024年3月

記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

記述言語：英語   会議種別：ポスター発表  

国名：オーストリア共和国  

記述言語：英語   会議種別：ポスター発表  

国名：ホンコン(香港)特別行政区  

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透析患者の尿酸値上昇と腸管ABCG2の機能低下の関連性

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