Updated on 2025/04/03

写真a

 
OHASHI Yuki
 
Organization
Graduate School of Medicine Assistant Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Assistant Professor
External link

Degree 1

  1. 博士（薬学） （ 2023.3   東京薬科大学 ） 

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Research Interests 3

  1. Uric acid

  2. トランスポーター

  3. 疫学

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Research Areas 1

  1. Life Science / Nephrology

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Education 2

  1. Tokyo University of Pharmacy and Life Science

    2019.4 - 2023.3

  2. Tokyo University of Pharmacy and Life Science

    2013.4 - 2019.3

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    Country： Japan

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Awards 1

  1. -

    2024.2   Japanese Society of Gout and Uric & Nucleic Acids  

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Papers 11

  1. First verification of human small intestinal uric acid secretion and effect of ABCG2 polymorphisms Open Access

    Miyazaki, R; Ohashi, Y; Sakurai, T; Iwamoto, T; Ichida, K; Saruta, M

    JOURNAL OF TRANSLATIONAL MEDICINE   Vol. 23 ( 1 )   2025.3

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    Publisher：Journal of Translational Medicine  

    DOI： 10.1186/s12967-025-06145-7

    Open Access

    Web of Science

    Scopus

    PubMed

  2. Associations among smoking, sleep quality, and decline in Mini-Mental State Examination scores based on health check-up data in Japan: a case-control study Open Access

    Nakatochi, M; Yoshida, K; Fujitani, M; Ohashi, Y; Kinoshita, F; Kobayashi, Y; Sato, H; Takahashi, Y; Murashita, K; Hirakawa, A

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 87 ( 1 ) page： 105 - 121   2025.2

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    Publisher：Nagoya Journal of Medical Science  

    The number of individuals with age-related mild cognitive impairment and subsequent dementia has inevitably increased with the rise in population aging. It is important to maintain cognitive function or decelerate declines in cognitive function. However, the evidence on lifestyle-based factors associated with this decline is lacking. Here, we investigated modifiable lifestyle-based factors associated with chronological cognitive decline in cognitively healthy adults aged ≥60 years (Mini-Mental State Examination [MMSE] score ≥27). This case-control study enrolled 363 participants who were divided into two groups based on annual declines in MMSE score: 40 cases with an MMSE score decline of ≥0.5 points/year and 323 controls with maintained MMSE scores. Smoking, lower social functioning scores on the 36-Item Short Form Health Survey version 2, higher Pittsburgh Sleep Quality Index (PSQI) global scores, and sleep disorders were significantly associated with a decline in MMSE scores. Multivariate logistic regression analysis revealed higher age, current smoking status, and either higher PSQI global scores or sleep disorders to be independently associated with MMSE score decline. In conclusion, the present study identified aging, smoking, and sleep quality as factors associated with a greater decline in MMSE scores in cognitively healthy individuals. Our findings highlight the potential importance of lifestyle factors in preventing cognitive decline.

    DOI： 10.18999/nagjms.87.1.105

    Open Access

    Web of Science

    Scopus

  3. Status of Community Pharmacy Functions and Regional Medical Collaboration System Initiatives in Japan Open Access

    Katsuta Daiki, Ohashi Yuki, Kamimura Minami, Sunaga Shinnosuke, Asami Yuichi, Kuriya Katsuhiro, Yamada Tetsuya, Masuyama Koichi, Kitagaki Kunihiko

    Biological and Pharmaceutical Bulletin   Vol. 47 ( 12 ) page： 2092 - 2100   2024.12

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    Language：English   Publisher：The Pharmaceutical Society of Japan  

    <p>With the increase in life expectancy in Japan, the proportion of older adults requiring medical assistance continues to increase. Hence, the Japanese government proposed the establishment of a community-based integrated care system, aimed at ensuring housing, medical care, long-term care, prevention, and lifestyle support in a comprehensive manner by 2025. To achieve this paradigm shift, pharmacies must collaborate with their respective medical providers. Therefore, we conducted a questionnaire survey to investigate the characteristics of pharmacies with successful regional medical collaborations. An original questionnaire was sent to 1200 randomly sampled pharmacies in Tokyo, of which 350 (29.2%) responded. These were evaluated based on the implementation of regional medical collaboration. The adequacy of a regional medical collaboration system was positively related to the operational structure (<i>e.g.</i>, staffing and information sharing within the pharmacy) and the number of hospitals (including clinics) issuing prescriptions. In addition, insufficient personnel and a lack of interaction with other medical providers were identified as major obstacles to implementing regional collaboration. Notably, the geographic distance from medical providers and the type of division of labor with medical providers were not associated with the adequacy of engagement in a regional medical collaboration system. The results of this study suggest that it may be possible to move closer to the realization of a community-based integrated care system through communication with other healthcare professionals and appropriate staffing regardless of the pharmacy’s business form.</p>

    DOI： 10.1248/bpb.b24-00316

    Open Access

    Web of Science

    Scopus

    PubMed

    CiNii Research

  4. A case of renal hypouricemia due to T217M mutation in SLC22A12 incidentally associated with IgA nephropathy Open Access

    Sakurabu, Y; Uchida, HA; Tahara, T; Asakawa, T; Yamasaki, H; Katayama, K; Okamoto, S; Onishi, Y; Matsuoka-Uchiyama, N; Tanaka, K; Takeuchi, H; Tsuji, K; Umebayashi, R; Ohashi, Y; Ichida, K; Wada, J

    CLINICAL CASE REPORTS   Vol. 12 ( 9 ) page： e9368   2024.9

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  5. Plasma and Urinary Metabolomic Analysis of Gout and Asymptomatic Hyperuricemia and Profiling of Potential Biomarkers: A Pilot Study. Reviewed

    Yuki Ohashi, Hiroshi Ooyama, Hideki Makinoshima, Tappei Takada, Hirotaka Matsuo, Kimiyoshi Ichida

    Biomedicines   Vol. 12 ( 2 )   2024.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/biomedicines12020300

  6. Changes in Regional Medical Collaboration System and Functions in Community Pharmacy Before and After the Enforcement of the Amended Act on Securing Quality, Efficacy and Safety of Products Including Pharmaceuticals and Medical Devices in Tokyo

    Katsuta Daiki, Ohashi Yuki, Kamimura Minami, Yamada Tetsuya, Masuyama Koichi, Kitagaki Kunihiko

    BPB Reports   Vol. 7 ( 6 ) page： 183 - 189   2024

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    Language：English   Publisher：The Pharmaceutical Society of Japan  

    <p>Over the past few decades, the number of older adults in desperate demand of social support is inevitably increasing with an aging population. Thus, there is a need for a social framework that can improve the quality of life of older adults. In Japan, where the population faces a super-aging society, the aim is to establish a community-based integrated care system that supports the elderly throughout the community. In August 2021, the Japanese government partially amended the Act on Securing Quality, Efficacy and Safety of Products Including Pharmaceuticals and Medical Devices to expand the flexible healthcare provision, which forms the basis of that system. This amendment encourages patients to choose pharmacies that better meet their needs by establishing a framework for publicly certifying pharmacies that play essential roles in community healthcare, including home healthcare, and pharmacies that can provide specialized medical care. However, the actual effects of the intervention remain unclear. Thus, we explored changes in efforts related to regional medical collaboration and functions in community pharmacies before and after the enforcement of the amended Act. Our survey revealed that the amendment increased the stockpiles of generic medicines at each pharmacy without a clear increase in the number of employees. Additionally, there was an across-the-board improvement in the provision of information to other medical providers and patients. These results indicated that the amendment to the Act directly or indirectly promoted a shift from conventional pharmacy to a more patient-oriented approach.</p>

    DOI： 10.1248/bpbreports.7.6_183

    CiNii Research

  7. Urate Transporter ABCG2 Function and Asymptomatic Hyperuricemia: A Retrospective Cohort Study of CKD Progression. Reviewed

    Yuki Ohashi, Satoru Kuriyama, Tomoko Nakano, Mai Sekine, Yu Toyoda, Akiyoshi Nakayama, Tappei Takada, Yusuke Kawamura, Takahiro Nakamura, Hirotaka Matsuo, Takashi Yokoo, Kimiyoshi Ichida

    American journal of kidney diseases   Vol. 81 ( 2 ) page： 134 - 144   2023.2

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1053/j.ajkd.2022.05.010

  8. Evaluation of ABCG2-mediated extra-renal urate excretion in hemodialysis patients. Reviewed

    Yuki Ohashi, Masao Toyoda, Nobumichi Saito, Masahiro Koizumi, Genta Kanai, Hirotaka Komaba, Moritsugu Kimura, Takehiko Wada, Hiroo Takahashi, Yuichiro Takahashi, Naoto Ishida, Takatoshi Kakuta, Masafumi Fukagawa, Kimiyoshi Ichida

    Scientific reports   Vol. 13 ( 1 ) page： 93 - 93   2023.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-022-26519-x

  9. Analysis of Purine Metabolism to Elucidate the Pathogenesis of Acute Kidney Injury in Renal Hypouricemia. Reviewed International coauthorship

    Daisuke Miyamoto, Nana Sato, Koji Nagata, Yukinao Sakai, Hitoshi Sugihara, Yuki Ohashi, Blanka Stiburkova, Ivan Sebesta, Kimiyoshi Ichida, Ken Okamoto

    Biomedicines   Vol. 10 ( 7 )   2022.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/biomedicines10071584

  10. Renal hypouricemia in a recipient of living-donor kidney transplantation: a case report and literature review. Reviewed

    Takamasa Miyauchi, Maho Terashita, Masatomo Ogata, Marie Murata, Kiyomi Osako, Naohiko Imai, Yuko Sakurai, Hideo Sasaki, Yuki Ohashi, Kimiyoshi Ichida, Yugo Shibagaki, Masahiko Yazawa

    CEN case reports   ( 2 ) page： 177 - 183   2022.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s13730-021-00647-1

  11. Dysfunctional ABCG2 gene polymorphisms are associated with serum uric acid levels and all-cause mortality in hemodialysis patients. Reviewed

    Akio Nakashima, Kimiyoshi Ichida, Ichiro Ohkido, Keitaro Yokoyama, Hirotaka Matsuo, Yuki Ohashi, Tappei Takada, Akiyoshi Nakayama, Hiroshi Suzuki, Nariyoshi Shinomiya, Mitsuyoshi Urashima, Takashi Yokoo

    Human cell   Vol. 33 ( 3 ) page： 559 - 568   2020.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s13577-020-00342-w

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Presentations 9

  1. -

    Yuki OHASHI, Kimiyoshi ICHIDA

    2024.2.29 

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    Event date： 2024.2 - 2024.3

    Language：Japanese   Presentation type：Oral presentation (general)  

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  2. CKD 患者に及ぼす尿酸トランスポーターABCG2 の保護的役割の解明

    大橋勇紀, 柴田茂, 高田龍平, 松尾洋孝, 内田俊也, 市田公美

    第 53 回日本痛風・尿酸核酸学会総会  2020.2.13 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  3. 遊離アミノ酸プロファイルを用いた血清尿酸値の規定因子の探索

    大橋勇紀, 市田公美

    第57回日本痛風・尿酸核酸学会総会  2024.2.29 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  4. Relation of Urate Transporter ABCG2 Function with Asymptomatic Hyperuricemia and Hypouricemia: A Retrospective Cohort Study of CKD Progression. International conference

    Yuki Ohashi, Satoru Kuriyama, Tomoko Nakano, Kimiyoshi Ichida

    FEBS Special Meeting 2023 ATP-Binding Cassette (ABC) Proteins: From multidrug Resistance to Genetic Disease  2023.3.1 

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    Language：English   Presentation type：Poster presentation  

    Country：Austria  

  5. Identification of Potential Biomarkers for the Progression from Asymptomatic Hyperuricemia to Gout using Plasma and Urinary Metabolomics. International conference

    Yuki Ohashi, Hiroshi Oyama, Hideki Makinoshima, Kimiyoshi Ichida

    24th Asia-Pacific League of Associations for Rheumatology Congress  2022.12 

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    Language：English   Presentation type：Poster presentation  

    Country：Hong Kong  

  6. ABCG2 による腎外尿酸排泄量の推定

    大橋勇紀, 豊田雅夫, 市田公美

    第 65 回日本腎臓学会学術総会  2022.6.11 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  7. 健常人における腎機能と ABCG2 機能低下の関係

    大橋勇紀, 中野知子, 栗山啓, 市田公美

    第 64 回日本腎臓学会学術総会  2021.6.19 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  8. Decreased ABCG2 Activity Accelerates the Age-Dependent Decline in Renal Function. International conference

    Yuki Ohashi, Satoru Kuriyama, Kimiyoshi Ichida

    The 19th International Purine and Pyrimidine Symposium (online)  2021.6.15 

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    Language：English   Presentation type：Oral presentation (general)  

  9. Renoprotective Effects of Urate Transporter ABCG2 in CKD patients International conference

    Yuki Ohashi, Shunya Uchida, Tappei Takada, Hirotaka Matsuo, Shigeru Shibata, Kimiyoshi Ichida

    FEBS Special Meeting 2020 ATP-Binding Cassette (ABC) Proteins: From multidrug Resistance to Genetic Disease  2020.3.5 

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    Language：English   Presentation type：Poster presentation  

    Country：Austria  

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Other research activities 2

  1. 月刊薬事 増刊「10 年間で登場した薬剤の市販後を総点検！ 病棟頻用薬の通信簿」

    2024.4

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  2. 月刊薬事9月号特集企画「透析患者のくすりの疑問」

    2023.9

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    透析患者の尿酸値上昇と腸管ABCG2の機能低下の関連性

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Research Project for Joint Research, Competitive Funding, etc. 2

  1. 分子遺伝疫学解析による尿酸トランスポーター機能と腎機能との関連性の解明

    2023.4 - 2025.3

    日本痛風・尿酸核酸学会 若手研究助成 

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    Authorship：Principal investigator 

    Grant amount：\200000

  2. .

    2023.4 - 2025.3

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KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. An international (Japan-USA-Vietnam) collaborative research for molecular genetic epidemiology in urate-related diseases including gout and hyperuricemia

    Grant number：24KK0177  2024.9 - 2027.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (International Collaborative Research)

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    Authorship：Coinvestigator(s) 

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  2. 尿酸トランスポーターの一塩基多型に着目した尿路結石症発症のリスク評価

    Grant number：23K19387  2023.8 - 2025.3

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

    大橋 勇紀

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\2860000 （ Direct Cost: \2200000 、 Indirect Cost：\660000 ）

    尿路結石症の生涯罹患率は男性で約15％、女性で約7％と非常に高く、その激しい疝痛と排尿困難から患者のQOLを著しく損なう。このような罹患率の高さ、また腎保護的な観点から、尿路結石症に対する予防やハイリスク群同定の医学的根拠の重要性は高い。しかしながら、シスチン尿症やキサンチン尿症のような一部の単一遺伝疾患以外の尿路結石症の遺伝的関与はほとんど明らかになっていない。本研究では尿酸動態に強く影響する尿酸トランスポーターであるABCG2に着目し、既知の健常集団とのABCG2遺伝子変異頻度の差異を調査する。さらには、ABCG2遺伝子多型による尿酸動態の変化と尿路結石症発症との関連性についても検討する。

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