所属
大学院工学研究科 物質プロセス工学専攻 物質創成工学 特任助教
職名
特任助教
外部リンク
リョン ヘイ マン
LEUNG Hei Man
LEUNG Hei Man
学位 3
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博士 （ 2015年3月 アデレード大学 ）
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（優等）理学士 （ 2008年8月 アデレード大学 ）
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理学士 （ 2007年7月 アデレード大学 ）
研究分野 2
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ナノテク・材料 / ナノ材料科学
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ナノテク・材料 / 分析化学
経歴 2
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理化学研究所 研究員
2019年4月 - 2023年12月
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沖縄科学技術大学院大学 研究員
2016年4月 - 2019年1月
受賞 6
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Fellowship to The 10th HOPE Meeting with Nobel Laureates
2018年 Japan Society for the Promotion of Science
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Postdoctoral Fellowship for Oversea Researchers
2016年 Japan Society for the Promotion of Science
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Dean’s Commendation for Doctoral Thesis Excellence
2015年 The University of Adelaide
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Australian Academy of Science Fellowships to the 63rd Lindau Nobel Laureate Meetings
2013年 The Science and Industry Endowment Fund
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Best Student Poster Presentation
2011年 The Royal Australian Chemical Institute
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Australian Postgraduate Award Scholarship
2010年 Australian Government
論文 10
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Electrical Contact of Metals at the Nanoscale Overcomes the Oxidative Susceptibility of Silver-Based Nanobiosensors 査読有り
Nikhil Bhalla, Afshan Jamshaid, Mandy H. M. Leung, Noriko Ishizu, Amy Q. Shen
ACS Applied Nano Materials 2 巻 ( 4 ) 頁： 2064 - 2075 2019年
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Microfluidic Assisted Nanoprecipitation of PLGA Nanoparticles for Curcumin Delivery to Leukemia Jurkat Cells 査読有り
Mandy H. M. Leung, Amy Q. Shen
LANGMUIR 34 巻 ( 13 ) 頁： 3961 - 3970 2018年4月
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Nanoprecipitation and Spectroscopic Characterization of Curcumin-Encapsulated Polyester Nanoparticles 査読有り
Mandy H. M. Leung, Takaaki Harada, Sheng Dai, Tak W. Kee
Langmuir 31 巻 ( 42 ) 頁： 11419 - 11427 2015年10月
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Delivery of Curcumin and Medicinal Effects of the Copper(II)-Curcumin Complexes 招待有り 査読有り
Mandy H. M. Leung, Takaaki Harada, Tak W. Kee
CURRENT PHARMACEUTICAL DESIGN 19 巻 ( 11 ) 頁： 2070 - 2083 2013年4月
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Femtosecond transient absorption spectroscopy of copper(II)-curcumin complexes 査読有り
Mandy H. M. Leung, Duc-Truc Pham, Stephen F. Lincoln,Tak W. Kee
PHYSICAL CHEMISTRY CHEMICAL PHYSICS 14 巻 ( 39 ) 頁： 13580 - 13587 2012年
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Reduction of Copper(II) to Copper(I) in the Copper-Curcumin Complex Induces Decomposition of Curcumin 査読有り
Mandy H. M. Leung, Pravena Mohan, Tara L. Pukala, Denis B. Scanlon, Stephen F. Lincoln, Tak W. Kee
AUSTRALIAN JOURNAL OF CHEMISTRY 65 巻 ( 5 ) 頁： 490 - 495 2012年
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Cooperative Binding and Stabilization of the Medicinal Pigment Curcumin by Diamide Linked gamma-Cyclodextrin Dimers: A Spectroscopic Characterization 査読有り
Takaaki Harada, Duc-Truc Pham, Mandy H. M. Leung, Huy Tien Ngo, Stephen F. Lincoln, Christopher J. Easton, Tak W. Kee
JOURNAL OF PHYSICAL CHEMISTRY B 115 巻 ( 5 ) 頁： 1268 - 1274 2011年2月
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The Role of Charge in the Surfactant-Assisted Stabilization of the Natural Product Curcumin 査読有り
Zifan Wang, Mandy H. M. Leung, Tak W. Kee, Douglas S. English
LANGMUIR 26 巻 ( 8 ) 頁： 5520 - 5526 2010年4月
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Effective Stabilization of Curcumin by Association to Plasma Proteins: Human Serum Albumin and Fibrinogen 査読有り
Mandy H. M. Leung, Tak W. Kee
LANGMUIR 25 巻 ( 10 ) 頁： 5773 - 5777 2009年5月
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Encapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis 査読有り
Mandy H. M. Leung, Hannah Colangelo, Tak W. Kee
LANGMUIR 24 巻 ( 11 ) 頁： 5672 - 5675 2008年6月
講演・口頭発表等 3
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Microfluidic Synthesis of Polyester Nanoparticles for the Delivery of Curcumin 招待有り 国際会議
Mandy H. M. Leung
IEEE-NANOMED2018 2018年12月
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Reduction of Copper(II) to Copper(I) in the Copper-Curcumin Complex Induces Decomposition of Curcumin 国際会議
Mandy H. M. Leung
2011 BioPhysChem Conference 2011年
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Spectroscopic Investigation on Curcumin – Tautomerization and Copper Complexation
Mandy H. M. Leung
2018年10月3日
科研費 2
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マイクロ流体過程を用いた効果的なクルクミン送達のためのポリエステルナノ粒子の合成
研究課題/研究課題番号：17F16720 2017年4月 - 2018年3月
科学研究費助成事業 特別研究員奨励費
SHEN Amy, LEUNG HEI MAN
The proposed research goals are completed smoothly as expected. A novel microfluidic assisted nanoprecipitation strategy that enables synthesis of surfactant-free curcumin encapsulated poly(lactide-co-glycolide) nanoparticles (Cur-PLGA NP) with adjustable particle diameters (30-70 nm) and narrow particle size distribution (polydispersity index less than 0.2). These results confirm that microfluidic devices for are useful in the development of novel polyester nanoparticles for drug delivery. In addition to the physical characterization of the synthesized Cur- PLGA NPs, its degradation kinetics in solution was investigated using UV-vis spectroscopy. The results indicated that these Cur- PLGA NPs are stable for days, furthermore, the encapsulated curcumin molecules are significantly solubilized and stabilized in an aqueous environment. Our Cur-PLGA NP exhibit excellent colloidal stability and inhibit degradation of curcumin. Furthermore, results from in vitro cell studies demonstrate the potential of our Cur-PLGA NP as an effective delivery system for curcumin. Our microfluidic assisted approach offers a controlled and effective nano-biomaterials synthesis of drug delivery system for curcumin, which can be extended to different capsule materials for a variety of biomedical applications. These results have been presented in international symposium and conference and has been published in an international peer-reviewed journal.
29年度が最終年度であるため、記入しない。
29年度が最終年度であるため、記入しない。 -
マイクロ流体過程を用いた効果的なクルクミン送達のためのポリエステルナノ粒子の合成
研究課題/研究課題番号：16F16720 2016年7月 - 2017年3月
科学研究費助成事業 特別研究員奨励費
SHEN Amy, LEUNG HEI MAN
The proposed research goals are completed smoothly as expected. Microfluidic devices for curcumin-polyester nanoparticle (Cur-PE-NPs) synthesis has been fabricated successfully. The synthesis of nanoparticle inside microfluidics devices was captured with confocal fluorescence microscope. The synthesized Cur-PE NPs were characterized with dynamic light scattering and target particle size distributions were achieved with the optimized devices. The average particle sizes are less than 100 nm with a polydispersity index of less than 0.2, which indicate the fabricated microfluidic devices provide a controlled environment for the formation of Cur-PE NPs. These results confirm that microfluidic devices are excellent tools in the development of novel polyester nanoparticles for drug delivery. In addition to the physical characterization of the synthesized Cur-PE NPs, its degradation kinetics in solution was investigated using UV-vis spectroscopy. The results indicated that these Cur-PE NPs are stable for days. Furthermore, the encapsulated curcumin molecules are significantly solubilized and stabilized in an aqueous environment. This research has demonstrated that microfluidic devices are unique platforms in the development of novel polyester nanoparticles for drug delivery. Our results suggest that the microfluidic synthesized Cur-PE NP have potential as drug carrier for curcumin. These results have been presented in international symposium and conference and a manuscript is currently in preparation for publication in an international peer-reviewed journal.
28年度が最終年度であるため、記入しない。
28年度が最終年度であるため、記入しない。
担当経験のある科目 (本学以外) 1
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Chemistry / Analytical Chemistry Laboratory Demonstrator
2007年 - 2015年 （The University of Adelaide）
科目区分：学部教養科目 国名：オーストラリア連邦