Updated on 2025/02/21

写真a

 
Mandy Hei Man LEUNG
 
Organization
Graduate School of Engineering Materials Process Engineering 2 Designated assistant professor
Title
Designated assistant professor
Other name(s)
Mandy
External link

Degree 3

  1. Ph.D ( 2015.3   The University of Adelaide ) 

  2. B.Sc (Honours) ( 2008.8   The University of Adelaide ) 

  3. B.Sc ( 2007.7   The University of Adelaide ) 

Research Interests 2

  1. Nanomaterial

  2. Physical Chemistry

Research Areas 1

  1. Nanotechnology/Materials / Analytical chemistry

Research History 3

  1. Nagoya University   Designated assistant professor

    2024.1

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  2. RIKEN   Researcher

    2019.4 - 2023.12

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  3. Okinawa Institute of Science and Technology Graduate University   Researcher

    2016.4 - 2019.1

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Education 2

  1. The University of Adelaide   PhD

    2011.2 - 2015.3

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  2. The University of Adelaide   B.Sc (Honours)

    2007.7 - 2008.8

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Awards 6

  1. Fellowship to The 10th HOPE Meeting with Nobel Laureates

    2018   Japan Society for the Promotion of Science  

  2. Postdoctoral Fellowship for Oversea Researchers

    2016   Japan Society for the Promotion of Science  

  3. Dean’s Commendation for Doctoral Thesis Excellence

    2015   The University of Adelaide  

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    Award type:International academic award (Japan or overseas) 

  4. Australian Academy of Science Fellowships to the 63rd Lindau Nobel Laureate Meetings

    2013   The Science and Industry Endowment Fund  

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    Award type:Award from international society, conference, symposium, etc. 

  5. Best Student Poster Presentation

    2011   The Royal Australian Chemical Institute  

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    Award type:Award from international society, conference, symposium, etc. 

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Papers 14

  1. Photo-Induced Synthesis of Ytterbium and Manganese-Doped CsPbCl3 Nanocrystals for Visible to Near-Infrared Photoluminescence with Negative Thermal Quenching. Reviewed International journal

    Xiaochen Fang, Zhuo Chen, Mandy Hei Man Leung, Biao Zheng, Liwei Wang, Meng An, Yusuke Asakura, Yusuke Yamauchi, Zhanhui Yuan

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)     page: e2408927   2024.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    Rare-earth-doped all-inorganic perovskite applications for near-infrared (NIR) emission are crucial for the construction of the next generation of intelligent lighting sources. However, the preparation of rare-earth-doped all-inorganic perovskite is complex, and difficult to control, and the issue of thermal quenching poses significant challenges to its practical application. Here, in order to address these issues, a convenient photo-induced synthesis method for CsPbCl3:Mn/Yb nanocrystals (NCs) is proposed by decomposing carbon tetrachloride with 365 nm light to provide chloride ions and regulate the formation of perovskite at room temperature. The negative thermal quenching in the NIR emission is achieved through the energy transfer between Mn and Yb. The emission intensity of Yb enhances 3.2 times when the temperature rises to ≈427 K. Furthermore, with the help of the orange emission from the Mn2+ ions and the NIR emission from the Yb3+ ions, visible to NIR light emitting diode (LED) devices are constructed and applied in orange light illumination and night vision imaging. This study enriches the preparation methods and chemical research on perovskite doping, which may open up new opportunities for the widespread application of perovskite-based materials or device engineering.

    DOI: 10.1002/advs.202408927

    PubMed

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  2. Flexible Mesopores in Nanoscrolls: Extraordinarily Large Alteration of Pore Sizes and Their Reversibility Reviewed International journal

    Yusuke Asakura, Mandy H.M. Leung, Yusuke Yamauchi

    Small   Vol. 20 ( 45 ) page: e2403814   2024.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    Flexible porous materials have gained considerable interest for their potential applications in selective absorption and controlled release/storage of specific molecules or compounds. Here, nanoscrolls are proposed as a type of inorganic solids with reversibly flexible mesopores. Nanoscrolls exhibit a rolled-up structure composed of nanosheets with a 1D rod-like morphology, possessing two distinct nanospaces. The first space comprises 1D tubular mesopores located at the center of the rod, while the second space exists in the interlayer regions on the wall of the mesopore, resulting from the layer stacking caused by the scrolling of nanosheets. By replacing the interlayer cations on the nanoscroll walls with other cations, a drastic alteration in the size of the 1D mesopores is observed. For instance, exchanging bulky dodecylammonium cations with small NH4+ cations leads to a substantial change in pore size, with differences ranging from 10 to 20 nm—a notably larger variation compared to previous reports on flexible porous materials. Importantly, the alteration of pore size induced by the exchange reaction is found to be reversible. This reversible alteration in pore size holds promise for applications in host–guest chemistry involving large moieties such as nanoparticles and enzymes.

    DOI: 10.1002/smll.202403814

    Scopus

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  3. Surface Insights of Mesoporous Fragile Organic Materials Under Ultra-Low-Voltage Directed by Gemini Column Reviewed

    Yusuke Asakura, Mandy H.M. Leung, Hirokatsu Miyata, Yusuke Yamauchi

    Advanced Materials Interfaces   Vol. 11 ( 25 )   2024.9

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    Publishing type:Research paper (scientific journal)  

    Mesoporous materials find widespread applications due to their high specific surface area, contributing to enhanced performance. Scanning electron microscopy (SEM) observation of mesoporous materials provides valuable insights into their mesostructures. However, direct observation of the outermost surfaces, which often dictate material properties, remains challenging, especially for highly insulating and fragile compounds. In this study, utilizing SEM observation with ultra-low-voltage acceleration directed by Gemini column is proposed to achieve direct surface imaging of mesoporous organic materials with highly insulating and fragile characteristics. By observing mesostructured polymers obtained through a soft-templating method without washing, stuffed pores are identified allowing the differentiation of micelle templates and polymer walls. Moreover, leveraging SEM measurements, a polymerization mechanism is proposed for dopamine on the polymer micelles adhered to the graphene oxide nanosheets. These findings demonstrate the potential of SEM measurements with ultra-low accelerating voltage in facilitating surface observations of polymer-derived nanomaterials characterized by high insulating properties and a fragile framework.

    DOI: 10.1002/admi.202400247

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  4. Time-resolved keto–enol tautomerization of the medicinal pigment curcumin Reviewed International journal

    Mandy H. M. Leung, Matthew A. Addicoat, Stephen F. Lincoln, Gregory F. Metha, Tak W. Kee

    Physical Chemistry Chemical Physics   Vol. 26 ( 20 ) page: 14970 - 14979   2024

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Curcumin is a medicinal agent that exhibits anti-cancer and anti-Alzheimer's disease properties. It has a keto-enol moiety that gives rise to many of its chemical properties including metal complexation and acid-base equilibria. A previous study has shown that keto-enol tautomerization at this moiety is implicated in the anti-Alzheimer's disease effect of curcumin, highlighting the importance of this process. In this study, tautomerization of curcumin in methanol, acetone and acetonitrile was investigated using time-resolved 1H nuclear magnetic resonance spectroscopy. Curcumin undergoes hydrogen-deuterium exchange with the solvents and the proton resonance peak corresponding to the hydrogen at the α-carbon position (Cα) decays as a function of time, signifying deuteration at this position. Because tautomerization is the rate limiting step in the deuteration of curcumin at the Cα position, the rate of tautomerization is inferred from the rate of deuteration. The rate constant of tautomerization of curcumin shows a temperature dependence and analysis using the Arrhenius equation revealed activation energies (Ea) of tautomerization of (80.1 ± 5.9), (64.1 ± 1.0) and (68.3 ± 5.5) kJ mol-1 in methanol, D2O/acetone and D2O/acetonitrile, respectively. Insight into the role of water in tautomerization of curcumin was further offered by density functional theory studies. The transition state of tautomerization was optimized in the presence of water molecules. The results show a hydrogen-bonded solvent bridge between the diketo moiety and Cα of curcumin. The Ea of tautomerization of curcumin shows a strong dependence on the number of water molecules in the solvent bridge, indicating the critical role played by the solvent bridge in catalyzing tautomerization of curcumin.

    DOI: 10.1039/D4CP01006J

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  5. Electrical Contact of Metals at the Nanoscale Overcomes the Oxidative Susceptibility of Silver-Based Nanobiosensors Reviewed

    Nikhil Bhalla, Afshan Jamshaid, Mandy H. M. Leung, Noriko Ishizu, Amy Q. Shen

    ACS Applied Nano Materials   Vol. 2 ( 4 ) page: 2064 - 2075   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    DOI: 10.1021/acsanm.9b00066

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Presentations 4

  1. Electroless Deposition of Metallic Mesoporous Films on Non-conductive Substrates

    Mandy Hei Man Leung

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    Event date: 2024.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  2. Microfluidic Synthesis of Polyester Nanoparticles for the Delivery of Curcumin Invited International conference

    Mandy H. M. Leung

    IEEE-NANOMED2018  2018.12 

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    Event date: 2018.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  3. Reduction of Copper(II) to Copper(I) in the Copper-Curcumin Complex Induces Decomposition of Curcumin International conference

    Mandy H. M. Leung

    2011 BioPhysChem Conference  2011 

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    Language:English   Presentation type:Poster presentation  

    Country:Australia  

  4. Spectroscopic Investigation on Curcumin – Tautomerization and Copper Complexation

    Mandy H. M. Leung

    2018.10.3 

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    Language:English   Presentation type:Oral presentation (general)  

    Country:Australia  

KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. Development of Curcumin Encapsulated Tri-Metallic Mesoporous Nanoparticles for Phototherapy

    Grant number:24K23050  2024.7 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Research Activity Start-up

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  2. マイクロ流体過程を用いた効果的なクルクミン送達のためのポリエステルナノ粒子の合成

    Grant number:17F16720  2017.4 - 2018.3

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

    SHEN Amy, LEUNG HEI MAN

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    The proposed research goals are completed smoothly as expected. A novel microfluidic assisted nanoprecipitation strategy that enables synthesis of surfactant-free curcumin encapsulated poly(lactide-co-glycolide) nanoparticles (Cur-PLGA NP) with adjustable particle diameters (30-70 nm) and narrow particle size distribution (polydispersity index less than 0.2). These results confirm that microfluidic devices for are useful in the development of novel polyester nanoparticles for drug delivery. In addition to the physical characterization of the synthesized Cur- PLGA NPs, its degradation kinetics in solution was investigated using UV-vis spectroscopy. The results indicated that these Cur- PLGA NPs are stable for days, furthermore, the encapsulated curcumin molecules are significantly solubilized and stabilized in an aqueous environment. Our Cur-PLGA NP exhibit excellent colloidal stability and inhibit degradation of curcumin. Furthermore, results from in vitro cell studies demonstrate the potential of our Cur-PLGA NP as an effective delivery system for curcumin. Our microfluidic assisted approach offers a controlled and effective nano-biomaterials synthesis of drug delivery system for curcumin, which can be extended to different capsule materials for a variety of biomedical applications. These results have been presented in international symposium and conference and has been published in an international peer-reviewed journal.

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  3. マイクロ流体過程を用いた効果的なクルクミン送達のためのポリエステルナノ粒子の合成

    Grant number:16F16720  2016.7 - 2017.3

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

    SHEN Amy, LEUNG HEI MAN

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    The proposed research goals are completed smoothly as expected. Microfluidic devices for curcumin-polyester nanoparticle (Cur-PE-NPs) synthesis has been fabricated successfully. The synthesis of nanoparticle inside microfluidics devices was captured with confocal fluorescence microscope. The synthesized Cur-PE NPs were characterized with dynamic light scattering and target particle size distributions were achieved with the optimized devices. The average particle sizes are less than 100 nm with a polydispersity index of less than 0.2, which indicate the fabricated microfluidic devices provide a controlled environment for the formation of Cur-PE NPs. These results confirm that microfluidic devices are excellent tools in the development of novel polyester nanoparticles for drug delivery. In addition to the physical characterization of the synthesized Cur-PE NPs, its degradation kinetics in solution was investigated using UV-vis spectroscopy. The results indicated that these Cur-PE NPs are stable for days. Furthermore, the encapsulated curcumin molecules are significantly solubilized and stabilized in an aqueous environment. This research has demonstrated that microfluidic devices are unique platforms in the development of novel polyester nanoparticles for drug delivery. Our results suggest that the microfluidic synthesized Cur-PE NP have potential as drug carrier for curcumin. These results have been presented in international symposium and conference and a manuscript is currently in preparation for publication in an international peer-reviewed journal.

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Teaching Experience (Off-campus) 1

  1. Chemistry / Analytical Chemistry Laboratory Demonstrator

    2007 - 2015 The University of Adelaide)

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    Level:Undergraduate (liberal arts)  Country:Australia