Organization
Graduate School of Engineering Materials Process Engineering 2 Designated assistant professor
Title
Designated assistant professor
External link
LEUNG Hei Man
Degree 3
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Ph.D （ 2015.3 The University of Adelaide ）
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B.Sc (Honours) （ 2008.8 The University of Adelaide ）
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B.Sc （ 2007.7 The University of Adelaide ）
Research Areas 2
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Nanotechnology/Materials / Nanomaterials
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Nanotechnology/Materials / Analytical chemistry
Research History 2
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Institute of Physical and Chemical Research Researcher
2019.4 - 2023.12
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Okinawa Institute of Science and Technology Researcher
2016.4 - 2019.1
Awards 6
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Fellowship to The 10th HOPE Meeting with Nobel Laureates
2018 Japan Society for the Promotion of Science
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Postdoctoral Fellowship for Oversea Researchers
2016 Japan Society for the Promotion of Science
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Dean’s Commendation for Doctoral Thesis Excellence
2015 The University of Adelaide
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Australian Academy of Science Fellowships to the 63rd Lindau Nobel Laureate Meetings
2013 The Science and Industry Endowment Fund
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Best Student Poster Presentation
2011 The Royal Australian Chemical Institute
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Australian Postgraduate Award Scholarship
2010 Australian Government
Papers 10
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Electrical Contact of Metals at the Nanoscale Overcomes the Oxidative Susceptibility of Silver-Based Nanobiosensors Reviewed
Nikhil Bhalla, Afshan Jamshaid, Mandy H. M. Leung, Noriko Ishizu, Amy Q. Shen
ACS Applied Nano Materials Vol. 2 ( 4 ) page： 2064 - 2075 2019
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Microfluidic Assisted Nanoprecipitation of PLGA Nanoparticles for Curcumin Delivery to Leukemia Jurkat Cells Reviewed
Mandy H. M. Leung, Amy Q. Shen
LANGMUIR Vol. 34 ( 13 ) page： 3961 - 3970 2018.4
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Nanoprecipitation and Spectroscopic Characterization of Curcumin-Encapsulated Polyester Nanoparticles Reviewed
Mandy H. M. Leung, Takaaki Harada, Sheng Dai, Tak W. Kee
Langmuir Vol. 31 ( 42 ) page： 11419 - 11427 2015.10
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Delivery of Curcumin and Medicinal Effects of the Copper(II)-Curcumin Complexes Invited Reviewed
Mandy H. M. Leung, Takaaki Harada, Tak W. Kee
CURRENT PHARMACEUTICAL DESIGN Vol. 19 ( 11 ) page： 2070 - 2083 2013.4
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Femtosecond transient absorption spectroscopy of copper(II)-curcumin complexes Reviewed
Mandy H. M. Leung, Duc-Truc Pham, Stephen F. Lincoln,Tak W. Kee
PHYSICAL CHEMISTRY CHEMICAL PHYSICS Vol. 14 ( 39 ) page： 13580 - 13587 2012
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Reduction of Copper(II) to Copper(I) in the Copper-Curcumin Complex Induces Decomposition of Curcumin Reviewed
Mandy H. M. Leung, Pravena Mohan, Tara L. Pukala, Denis B. Scanlon, Stephen F. Lincoln, Tak W. Kee
AUSTRALIAN JOURNAL OF CHEMISTRY Vol. 65 ( 5 ) page： 490 - 495 2012
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Cooperative Binding and Stabilization of the Medicinal Pigment Curcumin by Diamide Linked gamma-Cyclodextrin Dimers: A Spectroscopic Characterization Reviewed
Takaaki Harada, Duc-Truc Pham, Mandy H. M. Leung, Huy Tien Ngo, Stephen F. Lincoln, Christopher J. Easton, Tak W. Kee
JOURNAL OF PHYSICAL CHEMISTRY B Vol. 115 ( 5 ) page： 1268 - 1274 2011.2
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The Role of Charge in the Surfactant-Assisted Stabilization of the Natural Product Curcumin Reviewed
Zifan Wang, Mandy H. M. Leung, Tak W. Kee, Douglas S. English
LANGMUIR Vol. 26 ( 8 ) page： 5520 - 5526 2010.4
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Effective Stabilization of Curcumin by Association to Plasma Proteins: Human Serum Albumin and Fibrinogen Reviewed
Mandy H. M. Leung, Tak W. Kee
LANGMUIR Vol. 25 ( 10 ) page： 5773 - 5777 2009.5
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Encapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis Reviewed
Mandy H. M. Leung, Hannah Colangelo, Tak W. Kee
LANGMUIR Vol. 24 ( 11 ) page： 5672 - 5675 2008.6
Presentations 3
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Microfluidic Synthesis of Polyester Nanoparticles for the Delivery of Curcumin Invited International conference
Mandy H. M. Leung
IEEE-NANOMED2018 2018.12
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Reduction of Copper(II) to Copper(I) in the Copper-Curcumin Complex Induces Decomposition of Curcumin International conference
Mandy H. M. Leung
2011 BioPhysChem Conference 2011
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Spectroscopic Investigation on Curcumin – Tautomerization and Copper Complexation
Mandy H. M. Leung
2018.10.3
KAKENHI (Grants-in-Aid for Scientific Research) 2
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マイクロ流体過程を用いた効果的なクルクミン送達のためのポリエステルナノ粒子の合成
Grant number：17F16720 2017.4 - 2018.3
科学研究費助成事業 特別研究員奨励費
SHEN Amy, LEUNG HEI MAN
The proposed research goals are completed smoothly as expected. A novel microfluidic assisted nanoprecipitation strategy that enables synthesis of surfactant-free curcumin encapsulated poly(lactide-co-glycolide) nanoparticles (Cur-PLGA NP) with adjustable particle diameters (30-70 nm) and narrow particle size distribution (polydispersity index less than 0.2). These results confirm that microfluidic devices for are useful in the development of novel polyester nanoparticles for drug delivery. In addition to the physical characterization of the synthesized Cur- PLGA NPs, its degradation kinetics in solution was investigated using UV-vis spectroscopy. The results indicated that these Cur- PLGA NPs are stable for days, furthermore, the encapsulated curcumin molecules are significantly solubilized and stabilized in an aqueous environment. Our Cur-PLGA NP exhibit excellent colloidal stability and inhibit degradation of curcumin. Furthermore, results from in vitro cell studies demonstrate the potential of our Cur-PLGA NP as an effective delivery system for curcumin. Our microfluidic assisted approach offers a controlled and effective nano-biomaterials synthesis of drug delivery system for curcumin, which can be extended to different capsule materials for a variety of biomedical applications. These results have been presented in international symposium and conference and has been published in an international peer-reviewed journal.
29年度が最終年度であるため、記入しない。
29年度が最終年度であるため、記入しない。 -
マイクロ流体過程を用いた効果的なクルクミン送達のためのポリエステルナノ粒子の合成
Grant number：16F16720 2016.7 - 2017.3
科学研究費助成事業 特別研究員奨励費
SHEN Amy, LEUNG HEI MAN
The proposed research goals are completed smoothly as expected. Microfluidic devices for curcumin-polyester nanoparticle (Cur-PE-NPs) synthesis has been fabricated successfully. The synthesis of nanoparticle inside microfluidics devices was captured with confocal fluorescence microscope. The synthesized Cur-PE NPs were characterized with dynamic light scattering and target particle size distributions were achieved with the optimized devices. The average particle sizes are less than 100 nm with a polydispersity index of less than 0.2, which indicate the fabricated microfluidic devices provide a controlled environment for the formation of Cur-PE NPs. These results confirm that microfluidic devices are excellent tools in the development of novel polyester nanoparticles for drug delivery. In addition to the physical characterization of the synthesized Cur-PE NPs, its degradation kinetics in solution was investigated using UV-vis spectroscopy. The results indicated that these Cur-PE NPs are stable for days. Furthermore, the encapsulated curcumin molecules are significantly solubilized and stabilized in an aqueous environment. This research has demonstrated that microfluidic devices are unique platforms in the development of novel polyester nanoparticles for drug delivery. Our results suggest that the microfluidic synthesized Cur-PE NP have potential as drug carrier for curcumin. These results have been presented in international symposium and conference and a manuscript is currently in preparation for publication in an international peer-reviewed journal.
28年度が最終年度であるため、記入しない。
28年度が最終年度であるため、記入しない。
Teaching Experience (Off-campus) 1
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Chemistry / Analytical Chemistry Laboratory Demonstrator
2007 - 2015 （The University of Adelaide）
Level：Undergraduate (liberal arts) Country：Australia