Updated on 2024/01/04

写真a

 
TANABE Akira
 
Organization
Graduate School of Bioagricultural Sciences Department of Animal Sciences Assistant Professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences Department of Bioresource Sciences
Title
Assistant Professor
External link

Degree 1

  1. Doctor (Science) ( 2014.9   The Graduate University for Advanced Studies ) 

Research Interests 13

  1. CRISPR/Cas9

  2. Retrotransposon

  3. Coat color

  4. Behavior

  5. Behavioral genetics

  6. Genetic polymorphism

  7. Gene expression regulation

  8. Wild mouse

  9. cis-element

  10. Enhancer

  11. Genome editing

  12. Bioinformatics

  13. Mouse

Research Areas 5

  1. Life Science / Animal physiological chemistry, physiology and behavioral biology  / Behavioral genetics

  2. Life Science / Genetics  / Mouse genetics

  3. Life Science / Laboratory animal science  / Mouse

  4. Life Science / Developmental biology  / Developmental Gene Regulation

  5. Life Science / Genetics  / Behavioral genetics

Research History 9

  1. Nagoya University   Laboratory of Animal Genetics and Breeding, Graduate School of Bioagricultural Sciences   Assistant Professor

    2023.11

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    Country:Japan

  2. Nagoya University   Laboratory of Animal Genetics and Breeding, Graduate School of Bioagricultural Sciences   Researcher

    2023.10 - 2023.11

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    Country:Japan

  3. RIKEN Center for Biosystems Dynamics Research   Laboratory for Mouse Genetic Engineering   Researcher

    2020.4 - 2023.9

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    Country:Japan

  4. RIKEN Center for Biosystems Dynamics Research   Laboratory for Mouse Genetic Engineering   Researcher

    2018.9 - 2020.3

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    Country:Japan

  5. National Institute of Genetics, Research Organization of Information and Systems   Mouse Genomics Resource Laboratory, Genetic Strains Research Center   Researcher

    2016.4 - 2018.8

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    Country:Japan

  6. Transdisciplinary Research Integration Center, Research Organization of Information and Systems   Researcher

    2014.10 - 2016.3

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    Country:Japan

  7. National Institute of Genetics, Research Organization of Information and Systems   Mouse Genomics Resource Laboratory, Genetic Strains Research Center   Research assistant

    2009.4 - 2014.9

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    Country:Japan

  8. National Institute of Genetics, Research Organization of Information and Systems   Mouse Genomics Resource Laboratory, Genetic Strains Research Center   Technical assistant

    2008.5 - 2009.3

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    Country:Japan

  9. Kyushu Institute of Technology

    2004.5 - 2005.3

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    Country:Japan

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Education 2

  1. The Graduate University for Advanced Studies   School of Life Science   Department of Genetics

    2009.4 - 2014.9

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    Country: Japan

    Notes: Mouse Genomics Resource Laboratory

  2. Kyushu Institute of Technology   School of Computer Science and Systems Engineering   Department of Bioscience and Bioinformatics

    2004.4 - 2008.3

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    Country: Japan

Professional Memberships 5

  1. 日本分子生物学会

  2. 日本実験動物学会

  3. 日本神経科学学会

  4. 日本遺伝学会

  5. 行動神経内分泌研究会

Awards 8

  1. 優秀発表賞

    2020.6   Profes 2020 Summer  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  2. Travel Award

    2019.9   33rd International Mammalian Genome Conference  

  3. 優秀発表賞

    2018.11   Profes 2018 Winter  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  4. JSNP2016 Excellent Presentation Award

    2016.7   第46回日本神経精神薬理学会年会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Korea, Republic of

  5. Lorraine Flaherty Award

    2015.11   29th International Mammalian Genome Conference  

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

  6. Travel Award

    2012.5   14th Annual Meeting of the International Behavioural and Neural Genetics Society  

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    Award type:Award from international society, conference, symposium, etc.  Country:United States

  7. 若手優秀発表賞

    2012.5   第59回 日本実験動物学会総会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  8. Student Presentation Award

    2011.7   第15回 行動神経内分泌研究会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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Papers 12

  1. Efficient genome editing in wild strains of mice using the i-GONAD method. Reviewed International journal

    Yuji Imai, Akira Tanave, Makoto Matsuyama, Tsuyoshi Koide

    Scientific reports   Vol. 12 ( 1 ) page: 13821 - 13821   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    Wild mouse strains have been used for many research studies, because of the high level of inter-strain genetic and phenotypic variations in them, in addition to the characteristic phenotype maintained from wild mice. However, since application of the current genetic engineering method on wild strains is not easy, there are limited studies that have attempted to apply gene modification techniques in wild strains. Recently, i-GONAD, a new method for genome editing that does not involve any ex vivo manipulation of unfertilized or fertilized eggs has been reported. We applied i-GONAD method for genome editing on a series of wild strains and showed that genome editing is efficiently possible using this method. We successfully made genetically engineered mice in seven out of the nine wild strains. Moreover, we believe that it is still possible to apply milder conditions and improve the efficiencies for the remaining two strains. These results will open avenues for studying the genetic basis of various phenotypes that are characteristic to wild strains. Furthermore, applying i-GONAD will be also useful for other mouse resources in which genetic manipulation is difficult using the method of microinjection into fertilized eggs.

    DOI: 10.1038/s41598-022-17776-x

    PubMed

  2. A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome Reviewed

    Keiji Kawatani, Toshihiko Nambara, Nobutoshi Nawa, Hidetaka Yoshimatsu, Haruna Kusakabe, Katsuya Hirata, Akira Tanave, Kenta Sumiyama, Kimihiko Banno, Hidetoshi Taniguchi, Hitomi Arahori, Keiichi Ozono, Yasuji Kitabatake

    Communications Biology   Vol. 4 ( 1 )   2021.12

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    <title>Abstract</title>Astrocytes exert adverse effects on the brains of individuals with Down syndrome (DS). Although a neurogenic-to-gliogenic shift in the fate-specification step has been reported, the mechanisms and key regulators underlying the accelerated proliferation of astrocyte precursor cells (APCs) in DS remain elusive. Here, we established a human isogenic cell line panel based on DS-specific induced pluripotent stem cells, the <italic>XIST</italic>-mediated transcriptional silencing system in trisomic chromosome 21, and genome/chromosome-editing technologies to eliminate phenotypic fluctuations caused by genetic variation. The transcriptional responses of genes observed upon <italic>XIST</italic> induction and/or downregulation are not uniform, and only a small subset of genes show a characteristic expression pattern, which is consistent with the proliferative phenotypes of DS APCs. Comparative analysis and experimental verification using gene modification reveal dose-dependent proliferation-promoting activity of <italic>DYRK1A</italic> and <italic>PIGP</italic> on DS APCs. Our collection of human isogenic cell lines provides a comprehensive set of cellular models for further DS investigations.

    DOI: 10.1038/s42003-021-02242-7

    Other Link: http://www.nature.com/articles/s42003-021-02242-7

  3. The regulatory landscape of the Dlx gene system in branchial arches: Shared characteristics among Dlx bigene clusters and evolution. Reviewed

    Kenta Sumiyama, Akira Tanave

    Development, growth & differentiation   Vol. 62 ( 5 ) page: 355 - 362   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    The mammalian Dlx genes encode homeobox-type transcription factors and are physically organized as convergent bigene clusters. The paired Dlx genes share tissue specificity in the expression profile. Genetic regulatory mechanisms, such as intergenic enhancer sharing between paired Dlx genes, have been proposed to explain this conservation of bigene structure. All mammalian Dlx genes have expression and function in developing craniofacial structures, especially in the first and second pharyngeal arches (branchial arches). Each Dlx cluster (Dlx1/2, Dlx3/4, and Dlx5/6) has overlapping, nested expression in the branchial arches which is called the "Dlx code" and plays a key role in organizing craniofacial structure and evolution. Here we summarize cis-regulatory studies on branchial arch expression of the three Dlx bigene clusters and show some shared characteristics among the clusters, including cis-regulatory motifs, TAD (Topologically Associating Domain) boundaries, CTCF loops, and distal enhancer landscapes, together with a molecular condensate model for activation of the Dlx bigene cluster.

    DOI: 10.1111/dgd.12671

    PubMed

  4. A role for the rare endogenous retrovirus β4 in development of Japanese fancy mice. International journal

    Akira Tanave, Tsuyoshi Koide

    Communications biology   Vol. 3 ( 1 ) page: 53 - 53   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42003-020-0781-z

    PubMed

  5. Evaluation of introgressive hybridization among Cervidae in Japan's Kinki District via two novel genetic markers developed from public NGS data. Reviewed International journal

    Yuki Matsumoto, Toshihito Takagi, Ryosuke Koda, Akira Tanave, Asuka Yamashiro, Hidetoshi B Tamate

    Ecology and evolution   Vol. 9 ( 10 ) page: 5605 - 5616   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    Hybridization and backcrossing of native populations with introduced species can lead to introgression and genetic alteration. In this study, we evaluated introgression in 43 deer from a potential hybrid zone around Okinoshima Island, Kinki District, Japan. This region witnessed the migration of a hybrid population (cross between the Formosan sika deer [Cervus nippon taiouanus] and other deer species) that could potentially breed with the native Japanese sika deer (C. n. centralis). We used an existing genetic marker for the mitochondrial cytochrome b gene and two novel markers for nuclear DNA, developed using publicly available next-generation sequencing data. We identified one mainland deer with a mitochondrial haplotype identical to that of the Formosan sika deer as well as nuclear heterozygous sequences identical to those of Formosan and Japanese sika deer. This suggests that the mainland deer is a hybrid offspring of the Okinoshima population and native deer. However, only Japanese sika deer sequences were found in the other 42 samples, indicating limited introgression. Nevertheless, hybridization pre- and postintroduction in the Okinoshima population could cause multispecies introgression among Japanese sika deer, negatively affecting genetic integrity. We developed a simple test based on polymerase chain reaction-restriction fragment length polymorphism to detect introgression in natural populations. Our method can accelerate genetic monitoring of Japanese sika deer in Kinki District. In conclusion, to prevent further introgression and maintain genetic integrity of Japanese sika deer, we recommend establishing fences around Okinoshima Island to limit migration, besides a continued genetic monitoring of the native deer.

    DOI: 10.1002/ece3.5131

    PubMed

  6. Nested retrotransposition in the East Asian mouse genome causes the classical nonagouti mutation. Reviewed International journal

    Akira Tanave, Yuji Imai, Tsuyoshi Koide

    Communications biology   Vol. 2   page: 283 - 283   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    Black coat color (nonagouti) is a widespread classical mutation in laboratory mouse strains. The intronic insertion of endogenous retrovirus VL30 in the nonagouti (a) allele of agouti gene was previously reported as the cause of the nonagouti phenotype. Here, we report agouti mouse strains from East Asia that carry the VL30 insertion, indicating that VL30 alone does not cause the nonagouti phenotype. We find that a rare type of endogenous retrovirus, β4, was integrated into the VL30 region at the a allele through nested retrotransposition, causing abnormal splicing. Targeted complete deletion of the β4 element restores agouti gene expression and agouti coat color, whereas deletion of β4 except for a single long terminal repeat results in black-and-tan coat color. Phylogenetic analyses show that the a allele and the β4 retrovirus originated from an East Asian mouse lineage most likely related to Japanese fancy mice. These findings reveal the causal mechanism and historic origin of the classical nonagouti mutation.

    DOI: 10.1038/s42003-019-0539-7

    PubMed

  7. Measuring Active and Passive Tameness Separately in Mice. Reviewed International journal

    Hiromichi Nagayama, Yuki Matsumoto, Akira Tanave, Motoko Nihei, Tatsuhiko Goto, Tsuyoshi Koide

    Journal of visualized experiments : JoVE   ( 138 )   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    Domesticated animals such as dogs and laboratory mice show a high level of tameness, which is important for humans to handle them easily. Tameness has two behavioral components: a reluctance to avoid humans (passive tameness) and a motivation to approach humans (active tameness). To quantify these components in mice, we previously developed behavioral tests for active tameness, passive tameness, and the willingness to stay on a human hand, each designed to be completed within 3 min. The data obtained were used for selective breeding, with a large number of mice analyzed per generation. The active tameness test measures the movement of the mouse toward a human hand and the contact it engages in. The passive tameness test measures the duration of time that a mouse tolerates human touch. In the stay-on-hand test, a mouse is placed on a human hand and touched slowly using the thumb of that hand; the duration of time that the animal remains on the hand is measured. Here, we describe the test set-up and apparatus, explain the procedures, and discuss the appropriate data analysis. Finally, we explain how to interpret the results.

    DOI: 10.3791/58048

    PubMed

  8. Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice. Reviewed International journal

    Yasuyuki Horii, Tatsuhiro Nagasawa, Hiroyuki Sakakibara, Aki Takahashi, Akira Tanave, Yuki Matsumoto, Hiromichi Nagayama, Kazuto Yoshimi, Michiko T Yasuda, Kayoko Shimoi, Tsuyoshi Koide

    Scientific reports   Vol. 7 ( 1 ) page: 6991 - 6991   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    Group-housed male mice exhibit aggressive behaviour towards their cage mates and form a social hierarchy. Here, we describe how social hierarchy in standard group-housed conditions affects behaviour and gene expression in male mice. Four male C57BL/6 mice were kept in each cage used in the study, and the social hierarchy was determined from observation of video recordings of aggressive behaviour. After formation of a social hierarchy, the behaviour and hippocampal gene expression were analysed in the mice. Higher anxiety- and depression-like behaviours and elevated gene expression of hypothalamic corticotropin-releasing hormone and hippocampal serotonin receptor subtypes were observed in subordinate mice compared with those of dominant mice. These differences were alleviated by orally administering fluoxetine, which is an antidepressant of the selective serotonin reuptake inhibitor class. We concluded that hierarchy in the home cage affects behaviour and gene expression in male mice, resulting in anxiety- and depression-like behaviours being regulated differently in dominant and subordinate mice.

    DOI: 10.1038/s41598-017-07233-5

    PubMed

  9. Selective breeding and selection mapping using a novel wild-derived heterogeneous stock of mice revealed two closely-linked loci for tameness. Reviewed International journal

    Yuki Matsumoto, Tatsuhiko Goto, Jo Nishino, Hirofumi Nakaoka, Akira Tanave, Toshiyuki Takano-Shimizu, Richard F Mott, Tsuyoshi Koide

    Scientific reports   Vol. 7 ( 1 ) page: 4607 - 4607   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    Tameness is a major behavioral factor for domestication, and can be divided into two potential components: motivation to approach humans (active tameness) and reluctance to avoid humans (passive tameness). We identified genetic loci for active tameness through selective breeding, selection mapping, and association analysis. In previous work using laboratory and wild mouse strains, we found that laboratory strains were predominantly selected for passive tameness but not active tameness during their domestication. To identify genetic regions associated with active tameness, we applied selective breeding over 9 generations for contacting, a behavioural parameter strongly associated with active tameness. The prerequisite for successful selective breeding is high genetic variation in the target population, so we established and used a novel resource, wild-derived heterogeneous stock (WHS) mice from eight wild strains. The mice had genetic variations not present in other outbred mouse populations. Selective breeding of the WHS mice increased the contacting level through the generations. Selection mapping was applied to the selected population using a simulation based on a non-selection model and inferred haplotype data derived from single-nucleotide polymorphisms. We found a genomic signature for selection on chromosome 11 containing two closely linked loci.

    DOI: 10.1038/s41598-017-04869-1

    PubMed

  10. 動物の従順性行動に関する遺伝解析-家畜化に関わる遺伝子座の探索- Reviewed

    後藤達彦, 松本悠貴, 田邉 彰, 小出 剛

    動物遺伝育種研究   Vol. 43   page: 3 - 11   2015.9

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    Language:Japanese  

    DOI: 10.5924/abgri.43.3

  11. A male-specific QTL for social interaction behavior in mice mapped with automated pattern detection by a hidden Markov model incorporated into newly developed freeware. Reviewed International journal

    Toshiya Arakawa, Akira Tanave, Shiho Ikeuchi, Aki Takahashi, Satoshi Kakihara, Shingo Kimura, Hiroki Sugimoto, Nobuhiko Asada, Toshihiko Shiroishi, Kazuya Tomihara, Takashi Tsuchiya, Tsuyoshi Koide

    Journal of neuroscience methods   Vol. 234   page: 127 - 34   2014.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Owing to their complex nature, social interaction tests normally require the observation of video data by a human researcher, and thus are difficult to use in large-scale studies. We previously established a statistical method, a hidden Markov model (HMM), which enables the differentiation of two social states ("interaction" and "indifference"), and three social states ("sniffing", "following", and "indifference"), automatically in silico. NEW METHOD: Here, we developed freeware called DuoMouse for the rapid evaluation of social interaction behavior. This software incorporates five steps: (1) settings, (2) video recording, (3) tracking from the video data, (4) HMM analysis, and (5) visualization of the results. RESULTS: Using DuoMouse, we mapped a genetic locus related to social interaction. We previously reported that a consomic strain, B6-Chr6C(MSM), with its chromosome 6 substituted for one from MSM/Ms, showed more social interaction than C57BL/6 (B6). We made four subconsomic strains, C3, C5, C6, and C7, each of which has a shorter segment of chromosome 6 derived from B6-Chr6C, and conducted social interaction tests on these strains. DuoMouse indicated that C6, but not C3, C5, and C7, showed higher interaction, sniffing, and following than B6, specifically in males. COMPARISON WITH EXISTING METHOD: The data obtained by human observation showed high concordance to those from DuoMouse. The results indicated that the MSM-derived chromosomal region present in C6-but not in C3, C5, and C7-associated with increased social behavior. CONCLUSIONS: This method to analyze social interaction will aid primary screening for difference in social behavior in mice.

    DOI: 10.1016/j.jneumeth.2014.04.012

    PubMed

  12. Selection for reluctance to avoid humans during the domestication of mice Reviewed

    T. Goto, A. Tanave, K. Moriwaki, T. Shiroishi, T. Koide

    Genes, Brain and Behavior   Vol. 12 ( 8 ) page: 760 - 770   2013.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    Many animal species have been domesticated over the course of human history and became tame as a result of domestication. Tameness is a behavioral characteristic with 2 potential components: (1) reluctance to avoid humans and (2) motivation to approach humans. However, the specific behavioral characteristics selected during domestication processes remain to be clarified for many species. To quantify these 2 different components of tameness separately, we established 3 behavioral tests: the 'active tame', 'passive tame' and 'stay-on-hand' tests. We subjected genetically diverse mouse strains to these tests, including 10 wild strains (BFM/2Ms, PGN2/Ms, HMI/Ms, BLG2/Ms, NJL/Ms, KJR/Ms, SWN/Ms, CHD/Ms, MSM/Ms and CAST/Ei), a fancy strain (JF1/Ms) and 6 standard laboratory strains (C3H/HeNJcl, CBA/J, BALB/cAnNCrlCrlj, DBA/2JJcl, 129+Ter/SvJcl and C57BL/6JJcl). To analyze the effects of domestication, these 17 strains were divided into 2 groups: domesticated strains (fancy and laboratory strains) and wild strains. Significant differences between strains were observed in all traits, and the calculated estimates of broad-sense heritability were 0.15-0.72. These results illustrate that tameness in mice is significantly influenced by genetic background. In addition, they clearly show the differences in the features of tameness in domesticated and wild strains. Most of the domesticated strains showed significantly greater reluctance to avoid humans than wild strains, whereas there was no significant difference in the level of motivation to approach humans between these 2 groups. These results might help to clarify the genetic basis of tameness in mice. © 2013 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley &amp
    Sons Ltd.

    DOI: 10.1111/gbb.12088

    Scopus

    PubMed

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Books 2

  1. 「Medical Science Digest」2019. 8月号

    田邉彰, 隅山健太( Role: Contributor ,  Cutting Edge:ゲノム編集技術を用いたDlx遺伝子群機能解析)

    ニューサイエンス社  2019.7 

  2. 生物の科学 遺伝 2010年11月号

    田邉彰, 小出剛( Role: Contributor ,  Topics: 動物家畜化の鍵となる従順さの選択-家畜化によって現れたさまざまな変化との関連)

    医学書院  2010.11 

MISC 11

  1. 哺乳類Dlx5-6遺伝子クラスターの転写制御機構と進化

    隅山健太, 田邉彰

    日本進化学会大会プログラム・講演要旨集(Web)   Vol. 24th   2022

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  2. Long single-stranded oligonucleotide-mediated knock-in with CRISPR/Cas9 in rodents

    Kazuto Yoshimi, Yuji Imai, Akira Tanave, Tomoji Mashimo, Tsuyoshi Koide

    GENES & GENETIC SYSTEMS   Vol. 91 ( 6 ) page: 361 - 361   2016.12

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:GENETICS SOC JAPAN  

    Web of Science

  3. Genetic variation and expression diversity of pituitary adenylate cyclase-activating polypeptide (PACAP) gene in mouse

    Tsuyoshi Koide, Akira Tanave

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   Vol. 19   page: 53 - 53   2016.6

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:OXFORD UNIV PRESS  

    Web of Science

  4. High expression of PACAP gene and the molecular mechanism found in wild-mouse strain showing elevated anxiety-like behavior

    Akira Tanave, Tsuyoshi Koide, Kenta Sumiyama, Aki Takahashi

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   Vol. 19   page: 53 - 53   2016.6

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:OXFORD UNIV PRESS  

    Web of Science

  5. Wild-derived heterogeneous stock mice to find the loci associated with tame behavior

    Yuki Matsumoto, Tatsuhiko Goto, Hirofumi Nakaoka, Jo Nishino, Akira Tanave, Richard F. Mott, Tsuyoshi Koide

    GENES & GENETIC SYSTEMS   Vol. 89 ( 6 ) page: 314 - 314   2014.12

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:GENETICS SOC JAPAN  

    Web of Science

  6. Automatic Segmentation of Mouse States Using Hidden Markov Model and Characterization of Mouse Strain Using 2-state Markov Model

      Vol. 60 ( 1 ) page: 189 - 213   2012.6

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    Language:Japanese  

    CiNii Books

  7. Genetic and molecular analyses on mechanisms of the anxiety-like behavior in MSM-B6 consomic strains

    Tsuyoshi Koide, Aki Takahashi, Toshihiko Shiroishi, Akira Tanave

    NEUROSCIENCE RESEARCH   Vol. 71   page: E271 - E272   2011

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.neures.2011.07.1187

    Web of Science

  8. Software development for analyzing social interaction behaviors in mice using hidden Markov model

    Akira Tanave, Aki Takahashi, Toshiya Arakawa, Satoshi Kakihara, Shingo Kimura, Hiroki Sugimoto, Toshihiko Shiroishi, Kazuya Tomihara, Takashi Tsuchiya, Tsuyoshi Koide

    NEUROSCIENCE RESEARCH   Vol. 71   page: E387 - E387   2011

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.neures.2011.07.1698

    Web of Science

  9. Genetic-environmental factors underlying basis of behavioral diversity in mice

    Tsuyoshi Koide, Ayako Ishii, Akinori Nishi, Akira Tanave, Toshihiko Shiroishi, Aki Takahashi

    GENES & GENETIC SYSTEMS   Vol. 85 ( 6 ) page: 447 - 447   2010.12

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:GENETICS SOC JAPAN  

    Web of Science

  10. Genetic study of anxiety-like behaviors characteristic of wild mice

    Akira Tanave, Ayako Ishii, Toshihiko Shiroishi, Aki Takahashi, Tsuyoshi Koide

    NEUROSCIENCE RESEARCH   Vol. 68   page: E170 - E170   2010

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.neures.2010.07.2327

    Web of Science

  11. High-resolution mapping of anxiety-related traits using consomic mouse strains

    Akira Tanave, Ayako Ishii, Toshihiko Shiroishi, Aki Takahashi, Tsuyoshi Koide

    NEUROSCIENCE RESEARCH   Vol. 65   page: S151 - S151   2009

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.neures.2009.09.761

    Web of Science

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Works 2

  1. マウスの社会行動を自動解析するフリーウェア「DuoMouse」

    2014.5

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    Work type:Software   Location:Journal of Neuroscience Methods  

  2. 動物行動の経時的な活動を記録するためのフリーウェア「tanaMove」

    2013.10

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    Work type:Software   Location:Genes, Brain and Behavior  

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. Development of a new gene therapy method by activating alternative genes using enhancer knock-in

    Grant number:22K15032  2022.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists  Grant-in-Aid for Early-Career Scientists

 

Social Contribution 2

  1. Release of a tool to backup Slack messages

    Role(s):Advisor, Informant

    2022.8

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    Audience: College students, Graduate students, Teachers, Researchesrs, General, Scientific, Company, Civic organization, Governmental agency

    Type:Internet

    I released a Chrome extension that backs up Slack to an HTML file with its original appearance, and promoted it on social media. It continues to be provided today. To date, it has been used by more than 3,000 Slack users.

  2. 効率アップ! 次世代のマウス実験

    Role(s):Appearance

    BDR大阪 連携促進コーディネーター  第16回「誰でもわかるセミナーシリーズ」  大阪生命システム研究棟A棟1階ラウンジ  2019.7

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    Audience: General

    Type:Seminar, workshop

    高速ゲノム変異マウス作製支援ユニット(隅山研)では、ゲノム編集技術により作製した遺伝子改変マウスを用いて実験することで、哺乳類発生の進化のメカニズムを明らかにする研究をしています。
    私たちは独自の改良により、高効率で遺伝子を改変できるTriple CRISPR法を開発しました。これは従来の方法に比べ、実験に必要なマウスの数・時間・費用などを大幅に減らせる画期的な方法です。
    今回のセミナーでは、この画期的な方法の紹介に加え、マウス実験とはどういうもので、なぜマウスが必要で、ゲノム編集マウスとはなにか、それらの基本的な内容を身近な具体例と共に解説し、私たちの研究について分かりやすく紹介したいと思います。

    File: 190723_第16回「誰でもわかるセミナーシリーズ」_田邉v2.pdf

Media Coverage 2

  1. マウスの毛色 仕組み解明 遺伝研 実験用黒毛は日本由来 Newspaper, magazine

    日本経済新聞 朝刊  2019.9

  2. マウスの行動自動解析 三島の遺伝研・小出准教授らソフト開発 Internet

    静岡新聞  静岡新聞|NEWS  2014.5

Academic Activities 1

  1. Release of a tool to backup Slack messages International contribution

    Role(s):Save/Restore

    2022.8

     More details

    Type:Academic society, research group, etc. 

    I released a Chrome extension that backs up Slack to an HTML file with its original appearance, and promoted it on social media. It continues to be provided today. It has been used by more than 200 researchers so far.