Impact of FKBP52 on cell proliferation and hormone-dependent cancers. Invited Reviewed

Hanaki S and Shimada M

Cancer Sci.   Vol. 114 ( 7 ) page： 2729 - 2738   2023.4

Dephosphorylation of the EGFR protein by calcineurin at serine 1046/1047 enhances its stability. Reviewed

2. Masaki T, Habara M, Shibutani S, Hanaki S, Sato Y, Tomiyasu H, Shimada M.

Biochem Biophys Res Commun.   Vol. 641   page： 84 - 92   2023.1

Estrogen receptor α revised: Expression, structure, function, and stability. Invited Reviewed

Habara M and Shimada M

Bioessays   Vol. 44 ( 12 ) page： e2200148   2022.12

FKBP52 and FKBP51 Differentially Regulate the Stability of Estrogen Receptor in Breast Cancer. Reviewed

Habara M, Sato Y, Goshima T, Sakurai M, Imai H, Shimizu H, Katayama Y, Hanaki S, Masaki T, Morimoto M, Nishikawa S, Toyama T, Shimada M.

Proc. Natl. Acad. Sci. U S A   Vol. 119 ( 15 ) page： e2110256119   2022.4

Decoding the Phosphatase Code: Regulation of Cell Proliferation by Calcineurin. Invited Reviewed

Masaki T and Shimada M

Int J Mol Sci.   Vol. 23 ( 3 ) page： 1122   2022.1

Calcineurin regulates the stability and activity of estrogen receptor α. Reviewed

Masaki T, Habara M, Sato Y, Goshima T, Maeda K, Hanaki S, Shimada M.

Proc. Natl. Acad. Sci. U S A.   Vol. 118 ( 44 ) page： e2114258118   2021.11

Targeting EZH2 as cancer therapy. Invited Reviewed

Hanaki S and Shimada M

J Biochem.   Vol. 170 ( 1 ) page： 1 - 4   2021.9

PP1 regulatory subunit NIPP1 regulates transcription of E2F1 target genes following DNA damage. Reviewed

Hanaki S, Habara M, Masaki T, Maeda K, Sato Y, Nakanishi M, Shimada M.

Cancer Sci.   Vol. 112 ( 7 ) page： 2739 - 2752   2021.7

FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells. Reviewed

Maeda K, Habara M, Kawaguchi M, Matsumoto H, Hanaki S, Masaki T, Sato Y, Matsuyama H, Kunieda K, Nakagawa H,

Mol Oncol.   Vol. 16 ( 4 ) page： 940 - 956   2021.2

Phosphoglycerate mutase cooperates with Chk1 kinase to regulate glycolysis. Reviewed

Mikawa T, Shibata E, Shimada M, Ito K, Ito T, Kanda H, Takubo K, Lleonart ME, Inagaki N, Yokode M, Kondoh H.

iScience   Vol. 23 ( 7 ) page： 101306   2020.7

Calcineurin regulates cyclin D1 stability through dephosphorylation at T286. Reviewed

Goshima T, Habara M, Maeda K, Hanaki S, Kato Y, Shimada M.

Sci. Rep.   Vol. 9 ( 1 ) page： 12779   2019.9

Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase. Reviewed

Nishimura K, Johmura Y, Deguchi K, Jiang Z, Uchida KSK, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K, Nakanishi M

Nat. Commun.   Vol. 10 ( 1 ) page： 981   2019.2

The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy. Reviewed

Iwata T, Uchino T, Koyama A, Johmura Y, Koyama J, Saito T, Ishiguro S, Arikawa T, Komatsu S, Miyachi M, Sano T, Nakanishi M, Shimada M.

PLOS ONE   Vol. 12 ( 5 ) page： e0178221   2017.5

Aurora B twists on histones for activation. Invited Reviewed

Shimada M, Nakanishi M

Cell Cycle.   Vol. 15 ( 24 ) page： 3321 - 3322   2016.12

Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation. Reviewed

Johmura Y, Yamashita E, Shimada M, Nakanishi K., Nakanishi M.

Sci. Rep.   Vol. 6   page： 31194   2016.8

Essential role of auto-activation circuitry on Aurora B-mediated H2AX-pS121 in mitosis. Reviewed

Shimada M, Goshima T, Matsuo H, Johmura Y, Haruta M, Murata K, Tanaka H, Ikawa M, Nakanishi K, Nakanishi M.

Nat Commun.   Vol. 7   page： 12059   2016.7

Activation of endogenous retroviruses in Dnmt1–/– ESCs involves disruption of SETDB1-mediated repression by NP95 binding to hemimethylated DNA. Reviewed

Sharif J, Endo A. T, Nakayama M, Karimi M. M, Shimada M, Katsuyama K, Goyal P, Brind'Amour J, Sun M, Sun Z, Ishikura T, Mizutani-Koseki Y, Ohara O, Shinkai Y, Nakanishi M, Xie H, Lorincz C. M*, Koseki H.

Cell Stem Cell   Vol. 19 ( 1 ) page： 81 - 94   2016.7

Loss of maintenance DNA methylation results in abnormal DNA origin firing during DNA replication. Reviewed

Haruta M, Shimada M*, Nishiyama A, Johmura Y, Le Tallec B, Debatisse M, Nakanishi M.

Biochem. Biophys. Res. Commun.   Vol. 469 ( 4 ) page： 960 - 966   2016.1

Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis. Reviewed

Murata K, Sato S, Haruta M, Goshima T, Chiba Y, Takahashi S, Sharif J, Koseki H, Nakanishi M, Shimada M.

Biochem. Biophys. Res. Commun.   Vol. 458 ( 3 ) page： 470 - 475   2015.3

CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double strand break specific G2 checkpoint. Reviewed

Hirokawa T, Shiotani B, Shimada M, Murata K, Johmura Y, Haruta M, Tahara H, Takeyama H, Nakanishi M*:

Cancer Res.   Vol. 74 ( 14 ) page： 3880 - 3889   2014.7

Necessary and sufficient role for a mitosis skip in senescence induction. Reviewed

Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, Takahashi S, Nakanishi M.

Mol. Cell   Vol. 55 ( 1 ) page： 73 - 84   2014.7

Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-κB signaling pathway. Reviewed

1Goshima T, 1Shimada M (1Both authors contributed equally to this work), Sharif J, Matsuo H, Misaki T, Johmura Y, Murata K, Koseki H, Nakanishi M.

J Biol Chem.   Vol. 289 ( 17 ) page： 11656 - 11666   2014.4

Mitotic phosphorylation of MPP8 by cyclin-dependent kinases regulates chromatin dissociation Reviewed

Nishigaki M, Kawada Y, Misaki T, Murata K, Goshima T, Hirokawa T, Yamada C, Shimada M*, Nakanishi M.

Biochem. Biophys. Res. Commun.   Vol. 432 ( 4 ) page： 654 - 659   2013.3

Response to DNA damage: why do we need to focus on protein phosphatases? Invited Reviewed

Shimada M, Nakanishi M.

Front Oncol.   Vol. 3   page： 8   2013.1

Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells. Invited Reviewed

Niida H, Shimada M, Murakami H and Nakanishi M.

Cancer Sci.   Vol. 101 ( 12 ) page： 2505 - 2509   2010.12

Protein phosphatase 1γ is responsible for dephosphorylation of histone H3 at Thr11 after DNA damage. Reviewed

Shimada M, Haruta M, Niida H, Sawamoto K, Nakanishi M.

EMBO Rep.   Vol. 11 ( 11 ) page： 883 - 889   2010.11

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo. Reviewed

Niida H, Murata K, Shimada M, Ogawa K, Ohta K, Suzuki K, Fujigaki H, Khaw AK, Banerjee B, Hande MP, Miyamoto T, Miyoshi I, Shirai T, Motoyama N, Delhase M, Appella E, Nakanishi M.

EMBO J.   Vol. 29 ( 20 ) page： 3558 - 3570   2010.10

Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase. Reviewed

Niida H, Katsuno Y, Sengoku M, Shimada M, Yukawa M, Ikura M, Ikura T, Kohno K, Shima H, Suzuki H, Tashiro S, Nakanishi M.

Genes Dev.   Vol. 24 ( 4 ) page： 333 - 338   2010.2

Chk1-cyclin A/Cdk1 axis regulates origin firing programs in mammals. Invited Reviewed

Nakanishi M, Katsuno Y, Niida H, Murakami H, Shimada M.

Chromosome Res.   Vol. 18 ( 1 ) page： 103 - 113   2010.1

DNA damage responses in skin biology—implications in tumor prevention and aging acceleration. Invited Reviewed

Nakanishi M, Niida H, Murakami H, Shimada M.

J. Dermatol. Sci.   Vol. 56 ( 2 ) page： 76 - 81   2009.11

Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast. Reviewed

Shimada M, Yamamoto A, Murakami-Tonami Y, Nakanishi M, Yoshida T, Aiba H, Murakami H.

Biochem Biophys Res Commun.   Vol. 388 ( 3 ) page： 529 - 532   2009.10

Ptpcd-1 is a novel cell cycle related phosphatase that regulates centriole duplication and cytokinesis. Reviewed

Zineldeen DH, Shimada M, Niida H, Katsuno Y and Nakanishi M.

Biochem Biophys Res Commun.   Vol. 380 ( 3 ) page： 460 - 466   2009.3

Cyclin A-Cdk1 regulates the origin firing program in mammalian cells. Reviewed

Katsuno Y, Suzuki A, Sugimura K, Okumura K, Zineldeen DH, Shimada M, Niida H, Mizuno T, Hanaoka F, Nakanishi M.

Proc Natl Acad Sci U S A.   Vol. 106 ( 9 ) page： 3184 - 3189   2009.3

Essential role of Chk1 in S phase progression through regulation of RNR2 expression. Reviewed

Naruyama H, Shimada M, Niida H, Zineldeen DH, Hashimoto Y, Kohri K and Nakanishi M.

Biochem. Biophys. Res. Commun.   Vol. 374 ( 1 ) page： 79 - 83   2008.9

Checkpoints meet the transcription at a novel histone milestone (H3-T11). Invited Reviewed

Shimada M, Nakanishi M.

Cell Cycle.   Vol. 7 ( 11 ) page： 1555 - 1559   2008.6

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression Reviewed

Shimada M, Niida H, Zineldeen DH, Tagami H, Tanaka M, Saito H, Nakanishi M

CELL   Vol. 132 ( 2 ) page： 221 - 232   2008.1

Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast. Reviewed

Shimada M, Yamada-Namikawa C, Murakami-Tonami Y, Yoshida T, Nakanishi M, Urano T, Murakami H.

EMBO J.   Vol. 27 ( 1 ) page： 132 - 142   2008.1

Genetic instability in cancer cells by impaired cell cycle checkpoints. Invited Reviewed

Nakanishi M, Shimada M.

Cancer Sci.   Vol. 97 ( 10 ) page： 984 - 989   2006.10

DNA damage checkpoints and cancer. Invited Reviewed

Shimada M, Nakanishi M.

J. Mol. Histol.   Vol. 37   page： 253 - 260   2006

Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast. Reviewed

Shimada M, Namikawa-Yamada C, Nakanishi M, Murakami H.

J. Biol. Chem.,   Vol. 280 ( 38 ) page： 32640 - 32648   2005.9

The meiotic recombination checkpoint is regulated by checkpoint rad+ genes in fission yeast. Reviewed

Shimada M, Nabeshima K, Tougan T, Nojima H*

EMBO J   Vol. 21 ( 11 ) page： 2807 - 2818   2002.6

Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints. Reviewed

Shimada M, Okuzaki D, Tanaka S, Tougan T, Tamai KK, Shimoda C, Nojima H.

Mol. Biol. Cell,   Vol. 10 ( 12 ) page： 3991 - 4450   1999.12

Aurora B twists on histones for activation. Invited Reviewed

Shimada M, Nakanishi M.

Cell Cycle.   Vol. 15 ( 24 ) page： 3321 - 3322   2016.8

Response to DNA damage: why do we need to focus on protein phosphatases? Invited Reviewed

Shimada M, Nakanishi M.

Front Oncol.   Vol. 3 ( 8 )   2013.1

Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells. Invited Reviewed

Niida H, Shimada M, Murakami H, Nakanishi M.

Cancer Sci.   Vol. 101 ( 12 ) page： 2505 - 2509   2010.12

Chk1-cyclin A/Cdk1 axis regulates origin firing programs in mammals. Invited Reviewed

Nakanishi M, Katsuno Y, Niida H, Murakami H, Shimada M.

Chromosome Res.   Vol. 18 ( 1 ) page： 103 - 113   2010.1

DNA damage responses in skin biology—implications in tumor prevention and aging acceleration. Invited Reviewed

Nakanishi M, Niida H, Murakami H, Shimada M.

J. Dermatol. Sci.   Vol. 56 ( 2 ) page： 76 - 81   2009.11

チェックポイントキナーゼChk1による転写制御とストレス応答 Reviewed

中西 真, 島田 緑

細胞工学（秀潤社）   Vol. 28   page： 22 - 26   2009

Checkpoints meet the transcription at a novel histone milestone (H3-T11). Invited Reviewed

Shimada M, Nakanishi M.

Cell Cycle.   Vol. 7 ( 11 ) page： 1555 - 1559   2008.6

DNA損傷反応とクロマチン修飾 Reviewed

島田 緑, 中西 真

細胞工学（秀潤社）   Vol. 27   page： 1162 - 1167   2008

Chk1の新しい機能-ヒストンH3-Thr11のリン酸化を介した転写制御機構 Reviewed

島田 緑, 中西 真

実験医学（羊土社）   Vol. 26   page： 1740 - 1743   2008

Genetic instability in cancer cells by impaired cell cycle checkpoints. Invited Reviewed

Nakanishi M, Shimada M, Niida H.

Cancer Sci.   Vol. 97 ( 10 ) page： 984 - 989   2006.10

チェックポイントを制御するキナーゼ群 Reviewed

島田 緑, 中西 真

細胞工学（秀潤社）   Vol. 25   page： 924 - 928   2006

DNA damage checkpoints and cancer. Invited Reviewed

Shimada M, Nakanishi M.

J. Mol. Histol.   Vol. 37   page： 253 - 260   2006

リン酸化修飾が明らかにした多彩な細胞周期チェックポイント機能 Reviewed

島田 緑, 村上 浩士, 中西 真

実験医学（羊土社）   Vol. 23   page： 1999 - 2005   2005

減数分裂期におけるチェックポイント機構 Reviewed

島田 緑, 野島 博

化学と生物（日本農芸化学会）   Vol. 41   page： 84 - 91   2003