Updated on 2024/10/03

写真a

 
SHIMADA Midori
 
Organization
Graduate School of Medicine Program in Integrated Medicine Biological Chemistry Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor

Current Research Project and SDGs 1

  1. がんの治療標的に関する研究

 

Papers 47

  1. NFAT activation by FKBP52 promotes cancer cell proliferation by suppressing p53

    Hanaki, S; Habara, M; Tomiyasu, H; Sato, Y; Miki, Y; Masaki, T; Shibutani, S; Shimada, M

    LIFE SCIENCE ALLIANCE   Vol. 7 ( 8 )   2024.8

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    Language:English   Publisher:Life Science Alliance  

    FK506-binding protein 52 (FKBP52) is a member of the FKBP family of proline isomerases. FKBP52 is up-regulated in various cancers and functions as a positive regulator of steroid hormone receptors. Depletion of FKBP52 is known to inhibit cell proliferation; however, the detailed mechanism remains poorly understood. In this study, we found that FKBP52 depletion decreased MDM2 transcription, leading to stabilization of p53, and suppressed cell proliferation. We identified NFATc1 and NFATc3 as transcription factors that regulate MDM2. We also found that FKBP52 associated with NFATc3 and facilitated its nuclear translocation. In addition, calcineurin, a well-known Ca2+ phosphatase essential for activation of NFAT, plays a role in MDM2 transcription. Supporting this notion, MDM2 expression was found to be regulated by intracellular Ca2+. Taken together, these findings reveal a new role of FKBP52 in promoting cell proliferation via the NFAT-MDM2-p53 axis, and indicate that inhibition of FKBP52 could be a new therapeutic tool to activate p53 and inhibit cell proliferation.

    DOI: 10.26508/lsa.202302426

    Web of Science

    Scopus

    PubMed

  2. Calcineurin/NFATc1 pathway represses cellular cytotoxicity by modulating histone H3 expression

    Sato, Y; Habara, M; Hanaki, S; Sharif, J; Tomiyasu, H; Miki, Y; Shimada, M

    SCIENTIFIC REPORTS   Vol. 14 ( 1 ) page: 14732   2024.6

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    Language:English   Publisher:Scientific Reports  

    Excess amounts of histones in the cell induce mitotic chromosome loss and genomic instability, and are therefore detrimental to cell survival. In yeast, excess histones are degraded by the proteasome mediated via the DNA damage response factor Rad53. Histone expression, therefore, is tightly regulated at the protein level. Our understanding of the transcriptional regulation of histone genes is far from complete. In this study, we found that calcineurin inhibitor treatment increased histone protein levels, and that the transcription factor NFATc1 (nuclear factor of activated T cells 1) repressed histone transcription and acts downstream of the calcineurin. We further revealed that NFATc1 binds to the promoter regions of many histone genes and that histone transcription is downregulated in a manner dependent on intracellular calcium levels. Indeed, overexpression of histone H3 markedly inhibited cell proliferation. Taken together, these findings suggest that NFATc1 prevents the detrimental effects of histone H3 accumulation by inhibiting expression of histone at the transcriptional level.

    DOI: 10.1038/s41598-024-65769-9

    Web of Science

    Scopus

    PubMed

  3. FOXO1 promotes cancer cell growth through MDM2-mediated p53 degradation

    Tomiyasu H., Habara M., Hanaki S., Sato Y., Miki Y., Shimada M.

    Journal of Biological Chemistry   Vol. 300 ( 4 ) page: 107209   2024.4

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    Language:English   Publisher:Journal of Biological Chemistry  

    FOXO1 is a transcription factor and potential tumor suppressor that is negatively regulated downstream of PI3K-PKB/AKT signaling. Paradoxically, FOXO also promotes tumor growth, but the detailed mechanisms behind this role of FOXO are not fully understood. In this study, we revealed a molecular cascade by which the Thr24 residue of FOXO1 is phosphorylated by AKT and is dephosphorylated by calcineurin, which is a Ca2+-dependent protein phosphatase. Curiously, single nucleotide somatic mutations of FOXO1 in cancer occur frequently at and near Thr24. Using a calcineurin inhibitor and shRNA directed against calcineurin, we revealed that calcineurin-mediated dephosphorylation of Thr24 regulates FOXO1 protein stability. We also found that FOXO1 binds to the promoter region of MDM2 and activates transcription, which in turn promotes MDM2-mediated ubiquitination and degradation of p53. FOXO3a and FOXO4 are shown to control p53 activity; however, the significance of FOXO1 in p53 regulation remains largely unknown. Supporting this notion, FOXO1 depletion increased p53 and p21 protein levels in association with the inhibition of cell proliferation. Taken together, these results indicate that FOXO1 is stabilized by calcineurin-mediated dephosphorylation and that FOXO1 supports cancer cell proliferation by promoting MDM2 transcription and subsequent p53 degradation.

    DOI: 10.1016/j.jbc.2024.107209

    Scopus

    PubMed

  4. Dephosphorylation of NFAT by Calcineurin inhibits Skp2-mediated degradation

    Hanaki, S; Habara, M; Sato, Y; Tomiyasu, H; Miki, Y; Shibutani, S; Shimada, M

    JOURNAL OF BIOCHEMISTRY   Vol. 175 ( 3 ) page: 235 - 244   2024.3

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    Language:English   Publisher:Journal of Biochemistry  

    The transcription factor NFAT plays key roles in multiple biological activities, such as immune responses, tissue development and malignant transformation. NFAT is dephosphorylated by calcineurin, which is activated by intracellular calcium levels, and translocated into the nucleus, resulting in transcriptional activation. Calcineurin dephosphorylates various target proteins and regulates their functions. However, the regulation of NFAT degradation is largely unknown, and it is unclear whether calcineurin contributes to the stability of NFAT. We investigated the effect of calcineurin inhibition on NFAT protein stability and found that the dephosphorylation of NFAT by calcineurin promotes the NFAT stabilization, whereas calcineurin mutant that is defective in phosphatase activity was unable to stabilize NFAT. Increased intracellular calcium ion concentration, which is essential for calcineurin activation, also induced NFAT stability. In addition, we identified S-phase kinase associated protein 2 (Skp2), an F-box protein of the SCF ubiquitin ligase complex, as a factor mediating degradation of NFAT when calcineurin was depleted. In summary, these findings revealed that the dephosphorylation of NFAT by calcineurin protects NFAT from degradation by Skp2 and promotes its protein stability.

    DOI: 10.1093/jb/mvad103

    Web of Science

    Scopus

    PubMed

  5. Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc. Reviewed

    Masaki T, Habara M, Hanaki S, Sato Y, Tomiyasu H, Miki Y, Shimada M.

    Sci Rep.   Vol. 13 ( 1 ) page: 13116   2023.8

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-023-40412-1

  6. Impact of FKBP52 on cell proliferation and hormone-dependent cancers. Invited Reviewed

    Hanaki S and Shimada M

    Cancer Sci.   Vol. 114 ( 7 ) page: 2729 - 2738   2023.4

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.15811

  7. Dephosphorylation of the EGFR protein by calcineurin at serine 1046/1047 enhances its stability. Reviewed

    2. Masaki T, Habara M, Shibutani S, Hanaki S, Sato Y, Tomiyasu H, Shimada M.

    Biochem Biophys Res Commun.   Vol. 641   page: 84 - 92   2023.1

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  8. Estrogen receptor α revised: Expression, structure, function, and stability. Invited Reviewed

    Habara M and Shimada M

    Bioessays   Vol. 44 ( 12 ) page: e2200148   2022.12

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/bies.202200148.

  9. FKBP52 and FKBP51 Differentially Regulate the Stability of Estrogen Receptor in Breast Cancer. Reviewed

    Habara M, Sato Y, Goshima T, Sakurai M, Imai H, Shimizu H, Katayama Y, Hanaki S, Masaki T, Morimoto M, Nishikawa S, Toyama T, Shimada M.

    Proc. Natl. Acad. Sci. U S A   Vol. 119 ( 15 ) page: e2110256119   2022.4

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    DOI: 10.1073/pnas.2110256119

  10. Decoding the Phosphatase Code: Regulation of Cell Proliferation by Calcineurin. Invited Reviewed

    Masaki T and Shimada M

    Int J Mol Sci.   Vol. 23 ( 3 ) page: 1122   2022.1

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms23031122

  11. Calcineurin regulates the stability and activity of estrogen receptor α. Reviewed

    Masaki T, Habara M, Sato Y, Goshima T, Maeda K, Hanaki S, Shimada M.

    Proc. Natl. Acad. Sci. U S A.   Vol. 118 ( 44 ) page: e2114258118   2021.11

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.2114258118

  12. Targeting EZH2 as cancer therapy. Invited Reviewed

    Hanaki S and Shimada M

    J Biochem.   Vol. 170 ( 1 ) page: 1 - 4   2021.9

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jb/mvab007.

  13. PP1 regulatory subunit NIPP1 regulates transcription of E2F1 target genes following DNA damage. Reviewed

    Hanaki S, Habara M, Masaki T, Maeda K, Sato Y, Nakanishi M, Shimada M.

    Cancer Sci.   Vol. 112 ( 7 ) page: 2739 - 2752   2021.7

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14924.

  14. FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells. Reviewed

    Maeda K, Habara M, Kawaguchi M, Matsumoto H, Hanaki S, Masaki T, Sato Y, Matsuyama H, Kunieda K, Nakagawa H,

    Mol Oncol.   Vol. 16 ( 4 ) page: 940 - 956   2021.2

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/1878-0261.13030.

  15. Phosphoglycerate mutase cooperates with Chk1 kinase to regulate glycolysis. Reviewed

    Mikawa T, Shibata E, Shimada M, Ito K, Ito T, Kanda H, Takubo K, Lleonart ME, Inagaki N, Yokode M, Kondoh H.

    iScience   Vol. 23 ( 7 ) page: 101306   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.isci.2020.101306.

  16. Calcineurin regulates cyclin D1 stability through dephosphorylation at T286. Reviewed

    Goshima T, Habara M, Maeda K, Hanaki S, Kato Y, Shimada M.

    Sci. Rep.   Vol. 9 ( 1 ) page: 12779   2019.9

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    DOI: 10.1038/s41598-019-48976-7.

  17. Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase. Reviewed

    Nishimura K, Johmura Y, Deguchi K, Jiang Z, Uchida KSK, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K, Nakanishi M

    Nat. Commun.   Vol. 10 ( 1 ) page: 981   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-019-08957-w

  18. The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy. Reviewed

    Iwata T, Uchino T, Koyama A, Johmura Y, Koyama J, Saito T, Ishiguro S, Arikawa T, Komatsu S, Miyachi M, Sano T, Nakanishi M, Shimada M.

    PLOS ONE   Vol. 12 ( 5 ) page: e0178221   2017.5

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    DOI: 10.1371/journal.pone.0178221

  19. Aurora B twists on histones for activation. Invited Reviewed

    Shimada M, Nakanishi M

    Cell Cycle.   Vol. 15 ( 24 ) page: 3321 - 3322   2016.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/15384101.2016.1224758

  20. Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation. Reviewed

    Johmura Y, Yamashita E, Shimada M, Nakanishi K., Nakanishi M.

    Sci. Rep.   Vol. 6   page: 31194   2016.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep31194.

  21. Essential role of auto-activation circuitry on Aurora B-mediated H2AX-pS121 in mitosis. Reviewed

    Shimada M, Goshima T, Matsuo H, Johmura Y, Haruta M, Murata K, Tanaka H, Ikawa M, Nakanishi K, Nakanishi M.

    Nat Commun.   Vol. 7   page: 12059   2016.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms12059.

  22. Activation of endogenous retroviruses in Dnmt1–/– ESCs involves disruption of SETDB1-mediated repression by NP95 binding to hemimethylated DNA. Reviewed

    Sharif J, Endo A. T, Nakayama M, Karimi M. M, Shimada M, Katsuyama K, Goyal P, Brind'Amour J, Sun M, Sun Z, Ishikura T, Mizutani-Koseki Y, Ohara O, Shinkai Y, Nakanishi M, Xie H, Lorincz C. M*, Koseki H.

    Cell Stem Cell   Vol. 19 ( 1 ) page: 81 - 94   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.stem.2016.03.013.

  23. Loss of maintenance DNA methylation results in abnormal DNA origin firing during DNA replication. Reviewed

    Haruta M, Shimada M*, Nishiyama A, Johmura Y, Le Tallec B, Debatisse M, Nakanishi M.

    Biochem. Biophys. Res. Commun.   Vol. 469 ( 4 ) page: 960 - 966   2016.1

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    DOI: 10.1016/j.bbrc.2015.12.090.

  24. Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis. Reviewed

    Murata K, Sato S, Haruta M, Goshima T, Chiba Y, Takahashi S, Sharif J, Koseki H, Nakanishi M, Shimada M.

    Biochem. Biophys. Res. Commun.   Vol. 458 ( 3 ) page: 470 - 475   2015.3

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    DOI: 10.1016/j.bbrc.2015.01.122.

  25. CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double strand break specific G2 checkpoint. Reviewed

    Hirokawa T, Shiotani B, Shimada M, Murata K, Johmura Y, Haruta M, Tahara H, Takeyama H, Nakanishi M*:

    Cancer Res.   Vol. 74 ( 14 ) page: 3880 - 3889   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/0008-5472.CAN-13-3604.

  26. Necessary and sufficient role for a mitosis skip in senescence induction. Reviewed

    Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, Takahashi S, Nakanishi M.

    Mol. Cell   Vol. 55 ( 1 ) page: 73 - 84   2014.7

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    DOI: 10.1016/j.molcel.2014.05.003.

  27. Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-κB signaling pathway. Reviewed

    1Goshima T, 1Shimada M (1Both authors contributed equally to this work), Sharif J, Matsuo H, Misaki T, Johmura Y, Murata K, Koseki H, Nakanishi M.

    J Biol Chem.   Vol. 289 ( 17 ) page: 11656 - 11666   2014.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M113.541664.

  28. Mitotic phosphorylation of MPP8 by cyclin-dependent kinases regulates chromatin dissociation Reviewed

    Nishigaki M, Kawada Y, Misaki T, Murata K, Goshima T, Hirokawa T, Yamada C, Shimada M*, Nakanishi M.

    Biochem. Biophys. Res. Commun.   Vol. 432 ( 4 ) page: 654 - 659   2013.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2013.02.027.

  29. Response to DNA damage: why do we need to focus on protein phosphatases? Invited Reviewed

    Shimada M, Nakanishi M.

    Front Oncol.   Vol. 3   page: 8   2013.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fonc.2013.00008

  30. Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells. Invited Reviewed

    Niida H, Shimada M, Murakami H and Nakanishi M.

    Cancer Sci.   Vol. 101 ( 12 ) page: 2505 - 2509   2010.12

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  31. Protein phosphatase 1γ is responsible for dephosphorylation of histone H3 at Thr11 after DNA damage. Reviewed

    Shimada M, Haruta M, Niida H, Sawamoto K, Nakanishi M.

    EMBO Rep.   Vol. 11 ( 11 ) page: 883 - 889   2010.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/embor.2010.152.

  32. Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo. Reviewed

    Niida H, Murata K, Shimada M, Ogawa K, Ohta K, Suzuki K, Fujigaki H, Khaw AK, Banerjee B, Hande MP, Miyamoto T, Miyoshi I, Shirai T, Motoyama N, Delhase M, Appella E, Nakanishi M.

    EMBO J.   Vol. 29 ( 20 ) page: 3558 - 3570   2010.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/emboj.2010.218.

  33. Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase. Reviewed

    Niida H, Katsuno Y, Sengoku M, Shimada M, Yukawa M, Ikura M, Ikura T, Kohno K, Shima H, Suzuki H, Tashiro S, Nakanishi M.

    Genes Dev.   Vol. 24 ( 4 ) page: 333 - 338   2010.2

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    DOI: 10.1101/gad.1863810.

  34. Chk1-cyclin A/Cdk1 axis regulates origin firing programs in mammals. Invited Reviewed

    Nakanishi M, Katsuno Y, Niida H, Murakami H, Shimada M.

    Chromosome Res.   Vol. 18 ( 1 ) page: 103 - 113   2010.1

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    DOI: 10.1007/s10577-009-9086-2.

  35. DNA damage responses in skin biology—implications in tumor prevention and aging acceleration. Invited Reviewed

    Nakanishi M, Niida H, Murakami H, Shimada M.

    J. Dermatol. Sci.   Vol. 56 ( 2 ) page: 76 - 81   2009.11

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  36. Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast. Reviewed

    Shimada M, Yamamoto A, Murakami-Tonami Y, Nakanishi M, Yoshida T, Aiba H, Murakami H.

    Biochem Biophys Res Commun.   Vol. 388 ( 3 ) page: 529 - 532   2009.10

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    DOI: 10.1016/j.bbrc.2009.08.030.

  37. Ptpcd-1 is a novel cell cycle related phosphatase that regulates centriole duplication and cytokinesis. Reviewed

    Zineldeen DH, Shimada M, Niida H, Katsuno Y and Nakanishi M.

    Biochem Biophys Res Commun.   Vol. 380 ( 3 ) page: 460 - 466   2009.3

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    DOI: 10.1016/j.bbrc.2009.01.113

  38. Cyclin A-Cdk1 regulates the origin firing program in mammalian cells. Reviewed

    Katsuno Y, Suzuki A, Sugimura K, Okumura K, Zineldeen DH, Shimada M, Niida H, Mizuno T, Hanaoka F, Nakanishi M.

    Proc Natl Acad Sci U S A.   Vol. 106 ( 9 ) page: 3184 - 3189   2009.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.0809350106.

  39. Essential role of Chk1 in S phase progression through regulation of RNR2 expression. Reviewed

    Naruyama H, Shimada M, Niida H, Zineldeen DH, Hashimoto Y, Kohri K and Nakanishi M.

    Biochem. Biophys. Res. Commun.   Vol. 374 ( 1 ) page: 79 - 83   2008.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2008.06.112.

  40. Checkpoints meet the transcription at a novel histone milestone (H3-T11). Invited Reviewed

    Shimada M, Nakanishi M.

    Cell Cycle.   Vol. 7 ( 11 ) page: 1555 - 1559   2008.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4161/cc.7.11.6062

  41. Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression Reviewed

    Shimada M, Niida H, Zineldeen DH, Tagami H, Tanaka M, Saito H, Nakanishi M

    CELL   Vol. 132 ( 2 ) page: 221 - 232   2008.1

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    DOI: 10.1016/j.cell.2007.12.013.

  42. Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast. Reviewed

    Shimada M, Yamada-Namikawa C, Murakami-Tonami Y, Yoshida T, Nakanishi M, Urano T, Murakami H.

    EMBO J.   Vol. 27 ( 1 ) page: 132 - 142   2008.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.emboj.7601949.

  43. Genetic instability in cancer cells by impaired cell cycle checkpoints. Invited Reviewed

    Nakanishi M, Shimada M.

    Cancer Sci.   Vol. 97 ( 10 ) page: 984 - 989   2006.10

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  44. DNA damage checkpoints and cancer. Invited Reviewed

    Shimada M, Nakanishi M.

    J. Mol. Histol.   Vol. 37   page: 253 - 260   2006

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  45. Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast. Reviewed

    Shimada M, Namikawa-Yamada C, Nakanishi M, Murakami H.

    J. Biol. Chem.,   Vol. 280 ( 38 ) page: 32640 - 32648   2005.9

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    DOI: 10.1074/jbc.M504746200

  46. The meiotic recombination checkpoint is regulated by checkpoint rad+ genes in fission yeast. Reviewed

    Shimada M, Nabeshima K, Tougan T, Nojima H*

    EMBO J   Vol. 21 ( 11 ) page: 2807 - 2818   2002.6

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    DOI: 10.1093/emboj/21.11.2807.

  47. Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints. Reviewed

    Shimada M, Okuzaki D, Tanaka S, Tougan T, Tamai KK, Shimoda C, Nojima H.

    Mol. Biol. Cell,   Vol. 10 ( 12 ) page: 3991 - 4450   1999.12

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    DOI: https://doi.org/10.1091/mbc.10.12.3991

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Books 3

  1. エピジェネティクス実験スタンダード Reviewed

    島田 緑, 中西 真( Role: Joint author ,  ヒストンのリン酸化、ユビキチン化活性測定法)

    羊土社  2017 

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    Total pages:10   Language:Japanese Book type:Textbook, survey, introduction

  2. がん基盤生物学 Reviewed

    廣川 高久, 島田 緑, 竹山 廣光, 中西 真( Role: Joint author ,  G2/M期チェックポイントを標的としたがん細胞特異的抗がん療法増強剤の開発)

    南山堂  2013 

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    Total pages:7   Language:Japanese Book type:Textbook, survey, introduction

  3. 細胞周期フロンティア Reviewed

    廣川 高久, 島田 緑, 竹山 廣光, 中西 真( Role: Joint author ,  細胞老化とチェックポイント)

    共立出版  2010 

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    Total pages:5   Language:Japanese Book type:Textbook, survey, introduction

MISC 19

  1. Impact of FKBP52 on cell proliferation and hormone-dependent cancers. Invited Reviewed

    Hanaki S, Shimada M.

    Cancer Sci.   Vol. 114 ( 7 ) page: 2729 - 2738   2023.7

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    Authorship:Last author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1111/cas.15811.

  2. みにれびゅう「ER陽性乳がんの新規治療法開発に向けたエストロゲン受容体制御メカニズムの解明」 Reviewed

    羽原 誠, 島田 緑

    生化学(日本生化学会)   Vol. 95   page: 546 - 550   2023

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  3. Estrogen receptor α revised: Expression, structure, function, and stability. Invited Reviewed

    Habara M, Shimada M.

    Bioessays.   Vol. 44 ( 12 ) page: e2200148   2022.12

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    Authorship:Last author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1002/bies.202200148

  4. Decoding the Phosphatase Code: Regulation of Cell Proliferation by Calcineurin. Invited Reviewed

    Masaki T, Shimada M.

    Int J Mol Sci.   Vol. 23 ( 3 ) page: 1122   2022.1

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    Authorship:Last author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.3390/ijms23031122.

  5. Targeting EZH2 as cancer therapy. Invited Reviewed

    Hanaki S, Shimada M.

    J Biochem.   Vol. 170 ( 1 ) page: 1 - 4   2021.9

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1093/jb/mvab007.

  6. Aurora B twists on histones for activation. Invited Reviewed

    Shimada M, Nakanishi M.

    Cell Cycle.   Vol. 15 ( 24 ) page: 3321 - 3322   2016.8

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    Authorship:Lead author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1080/15384101.2016.1224758.

  7. Response to DNA damage: why do we need to focus on protein phosphatases? Invited Reviewed

    Shimada M, Nakanishi M.

    Front Oncol.   Vol. 3 ( 8 )   2013.1

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    Authorship:Lead author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.3389/fonc.2013.00008.

  8. Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells. Invited Reviewed

    Niida H, Shimada M, Murakami H, Nakanishi M.

    Cancer Sci.   Vol. 101 ( 12 ) page: 2505 - 2509   2010.12

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  9. Chk1-cyclin A/Cdk1 axis regulates origin firing programs in mammals. Invited Reviewed

    Nakanishi M, Katsuno Y, Niida H, Murakami H, Shimada M.

    Chromosome Res.   Vol. 18 ( 1 ) page: 103 - 113   2010.1

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    Authorship:Last author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1007/s10577-009-9086-2.

  10. DNA damage responses in skin biology—implications in tumor prevention and aging acceleration. Invited Reviewed

    Nakanishi M, Niida H, Murakami H, Shimada M.

    J. Dermatol. Sci.   Vol. 56 ( 2 ) page: 76 - 81   2009.11

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    Authorship:Last author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  11. チェックポイントキナーゼChk1による転写制御とストレス応答 Reviewed

    中西 真, 島田 緑

    細胞工学(秀潤社)   Vol. 28   page: 22 - 26   2009

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  12. Checkpoints meet the transcription at a novel histone milestone (H3-T11). Invited Reviewed

    Shimada M, Nakanishi M.

    Cell Cycle.   Vol. 7 ( 11 ) page: 1555 - 1559   2008.6

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    Authorship:Lead author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.4161/cc.7.11.6062.

  13. DNA損傷反応とクロマチン修飾 Reviewed

    島田 緑, 中西 真

    細胞工学(秀潤社)   Vol. 27   page: 1162 - 1167   2008

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  14. Chk1の新しい機能-ヒストンH3-Thr11のリン酸化を介した転写制御機構 Reviewed

    島田 緑, 中西 真

    実験医学(羊土社)   Vol. 26   page: 1740 - 1743   2008

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  15. Genetic instability in cancer cells by impaired cell cycle checkpoints. Invited Reviewed

    Nakanishi M, Shimada M, Niida H.

    Cancer Sci.   Vol. 97 ( 10 ) page: 984 - 989   2006.10

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  16. DNA damage checkpoints and cancer. Invited Reviewed

    Shimada M, Nakanishi M.

    J. Mol. Histol.   Vol. 37   page: 253 - 260   2006

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    Authorship:Lead author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  17. チェックポイントを制御するキナーゼ群 Reviewed

    島田 緑, 中西 真

    細胞工学(秀潤社)   Vol. 25   page: 924 - 928   2006

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  18. リン酸化修飾が明らかにした多彩な細胞周期チェックポイント機能 Reviewed

    島田 緑, 村上 浩士, 中西 真

    実験医学(羊土社)   Vol. 23   page: 1999 - 2005   2005

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  19. 減数分裂期におけるチェックポイント機構 Reviewed

    島田 緑, 野島 博

    化学と生物(日本農芸化学会)   Vol. 41   page: 84 - 91   2003

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. Gene expression by the three-dimensional histone code

    Grant number:24K02227  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator 

    Grant amount:\18590000 ( Direct Cost: \14300000 、 Indirect Cost:\4290000 )