Updated on 2024/10/11

写真a

 
JINNO Takanori
 
Organization
Nagoya University Hospital Assistant professor of hospital
Title
Assistant professor of hospital

Degree 1

  1. 学士(医学) ( 2011.3   信州大学 ) 

 

Papers 17

  1. Usefulness of fluorescent ureteral navigation in total pelvic exenteration using a two-team approach for locally recurrent pelvic malignancies-A video vignette

    Ogura, A; Murata, Y; Jinno, T; Yoshikawa, N; Kajiyama, H; Ebata, T

    COLORECTAL DISEASE     2024.2

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    Language:English   Publisher:Colorectal Disease  

    DOI: 10.1111/codi.16897

    Web of Science

    Scopus

    PubMed

  2. Optimal Surgical Indications for Resectable Metastatic Colorectal Cancer with BRAF V600E Mutation

    Jinno Takanori, Uehara Kay, Ogura Atsushi, Murata Yuki, Yokoyama Yukihiro, Kokuryo Toshio, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Ebata Tomoki

    The Japanese Journal of Gastroenterological Surgery   Vol. 55 ( 8 ) page: 473 - 482   2022.8

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    Language:Japanese   Publisher:The Japanese Society of Gastroenterological Surgery  

    <p><b>Purpose:</b> Patients with metastatic colorectal cancer (mCRC) with BRAF V600E mutation have a poor response to standard cytotoxic agents and extremely poor outcomes. Thus, the optimal indication for metastasectomy remains debatable, even when the metastatic region is resectable. The aims of this retrospective study were to examine the outcomes of BRAF V600E mCRC, identify risk factors for poor survival, and establish the optimal surgical indication for resection. <b>Materials and Methods:</b> The subjects were 14 patients with BRAF V600E mCRC who started treatment in our department between December 2016 and April 2020. No patients underwent surgery prior to introduction of systemic chemotherapy. Patients were divided into two groups based on the initial response to first-line chemotherapy: controlled disease (CD, <i>n</i>=8) for tumors that shrunk or stabilized from baseline, and uncontrolled disease (UD, <i>n</i>=6) for tumors that increased in size. <b>Results:</b> The median follow-up period was 39.7 months. The 2-year overall survival rate was 35.7% in all patients, and was higher in the CD group than in the UD group (50.0% vs. 16.7%, <i>P</i>=0.051). Six patients (42.9%) underwent curative metastasectomy, of whom 4 developed recurrence and one underwent re-resection. In the CD group, 2 of 3 patients who underwent metastasectomy were alive without cancer, while all 3 patients in the UD group developed recurrence after metastasectomy and 2 had early recurrence within 3 months. <b>Conclusion:</b> This study suggests that evaluation of the initial response to first-line chemotherapy may be a useful prognostic factor in BRAF V600E mCRC. Even if a tumor is resectable, the indication for metastasectomy should be carefully considered in cases with poor disease control in the initial response.</p>

    DOI: 10.5833/jjgs.2021.0129

    Scopus

    CiNii Research

  3. The carcinoembryonic antigen ratio is a potential predictor of survival in recurrent colorectal cancer

    Suzuki, Y; Ogura, A; Uehara, K; Aiba, T; Ohara, N; Murata, Y; Jinno, T; Mishina, T; Sato, Y; Hattori, N; Nakayama, G; Kodera, Y; Ebata, T

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 26 ( 7 ) page: 1264 - 1271   2021.7

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    Language:English   Publisher:International Journal of Clinical Oncology  

    Background: The carcinoembryonic antigen (CEA) “value” itself is often useless in patients with a normal CEA level at initial presentation and those with tumor-irrelevant elevated CEA. Although the unified marker using CEA has been desirable for recurrent tumor staging as well as for primary tumor staging, little is known concerning its relationship with the survival of patients with recurrent colorectal cancer in particular. Methods: This retrospective historical study included patients who experienced disease relapse after curative surgery for stage I–III colorectal cancer between 2006 and 2018. A total of 129 patients with recurrent disease after curative surgery for colorectal cancer were included. We focused on the CEA “ratio” (CEA-R: the ratio of the CEA level at the time of recurrence to that measured 3 months before recurrence) and aimed to evaluate the correlation between CEA-R and survival in recurrent colorectal cancer. Results: Patients with a high CEA-R (≥ 2) exhibited significantly worse 2 year survival than those with a low CEA-R (< 2) (88.1% vs. 44.9%, P < 0.001), irrespective of the CEA value before primary resection. Multivariate analyses demonstrated that the CEA-R (HR; 3.270, 95% CI 1.646–6.497, P = 0.001) was a significant prognostic factor. Conclusion: The CEA-R is a potential marker stratifying the survival of patients with disease relapse who exhibit aggressive biology at recurrent disease foci. As a novel marker, the CEA-R would serve as a clinical guide for tailoring treatment strategies at the time of disease relapse in patients with colorectal cancer.

    DOI: 10.1007/s10147-021-01919-7

    Web of Science

    Scopus

    PubMed

  4. Pathological Complete Response to Second Line Chemotherapy in a Patient with Cervical Lymph Node Metastasis from Transverse Colon Cancer with RAS and BRAF V600E Mutations: A Case Report

    Murata Yuki, Uehara Kay, Aiba Toshisada, Ogura Atsushi, Fukaya Masahide, Miyata Kazushi, Tanaka Aya, Ohara Noriaki, Jinno Takanori, Ebata Tomoki

    The Japanese Journal of Gastroenterological Surgery   Vol. 54 ( 4 ) page: 278 - 284   2021.4

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    Language:Japanese   Publisher:The Japanese Society of Gastroenterological Surgery  

    <p>Patients with colorectal cancer with the BRAF V600E mutation, which rarely coexists with a RAS mutation, have an extremely poor prognosis. In contrast, the outcomes of patients with a BRAF mutation and high microsatellite instability (MSI-high) have been found to be favorable. Thus, the significance of having multiple mutations remains unclear. We experienced a rare case with cervical lymph node metastasis from right-sided transverse colon cancer with RAS mutation, BRAF mutation and MSI-high, which developed 9 months after primary resection, just after completion of oxaliplatin-based 6-month adjuvant chemotherapy. As second-line chemotherapy, the patient received FOLFIRI plus aflibercept for 12 months. The tumor shrank markedly from 37 mm to 12 mm in maximum diameter and no new lesion was found; therefore, she underwent conversion surgery. Pathological findings confirmed no residual cancer cells (pathological complete response). Although the postoperative follow-up period is still <9 months, the patient has had no additional treatment after conversion surgery and is alive without recurrence. This case suggests that even in patients with metastatic colorectal cancer with the BRAF V600E mutation, aggressive surgical treatment might be an option in a situation of well-controlled systemic disease similar to that without a BRAF mutation. Further investigation of the significance of coexisting MSI-high with a BRAF mutation is required.</p>

    DOI: 10.5833/jjgs.2020.0057

    Scopus

    CiNii Research

  5. Laparoscopic Sacrocolpopexy with Ventral Rectopexy for a patient with Persistent Descending Mesocolon – A case report.

    Kato Takehiro, Morioka Jun, Kobayashi Satoshi, Takagi Takehiro, Jinno Takanori, Hori Akihiro

    Journal of Female Pelvic Floor Medicine   Vol. 17 ( 1 ) page: 19 - 23   2021.1

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    Language:Japanese   Publisher:Japanese Society of Female Felvic Floor Medicine  

    <p>An 86-year-old female without any histories of neither abdominal surgery nor peritonitis presented with rectal prolapse and pelvic organ prolapse. We planned to perform laparoscopic sacrocolpopexy with ventral rectopexy (LSC+LVR). The preoperative CT revealed medially displaced descending colon and no SD-junction at the supposed area, and the patient was considered as having persistent descending mesocolon. Intraoperative findings revealed dense matted adhesion of sigmoid colon with mesentery and right pelvic wall. L5S1 anterior longitudinal ligament was exposed and secured the anchoring suture after the dissection of these adhesions and consecutive plane oriented presacral dissection, and LSC+LVR was completed. The peritoneal closure was also completed although was complicated due to widely dissected area. Operative time was 190 min, blood loss was minimal, and no complication or recurrence was observed by 1 year after operation. Dense adhesion inside pelvis with PDM could be some difficulty during LSC procedure, herein we report the case.</p>

    DOI: 10.32310/jfpfm.17.1_19

    CiNii Research

  6. A Case of Strangulation Ileus Due to Vitelline Vascular Remnants without Meckel’s Diverticulum

    Jinno Takanori, Morioka Jun, Kobayashi Satoshi, Komaya Kenichi, Takagi Takehiro, Hori Akihiro

    The Japanese Journal of Gastroenterological Surgery   Vol. 54 ( 1 ) page: 50 - 56   2021.1

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    Language:Japanese   Publisher:The Japanese Society of Gastroenterological Surgery  

    <p>A 80-year-old woman visited our hospital with a complaint of abdominal pain and vomiting. Her abdomen showed muscular guarding with tenderness in the right lower quadrant. Abdominal CT showed an area of poor contrast of the small intestine in the right lower abdomen with surrounding ascites. We diagnosed strangulation ileus in the small intestine and performed emergency surgery. In surgery, the cord was found to be continuous from the posterior wall at the umbilicus into the abdominal cavity, and the small intestine was strangulated. The strangulation was released when the cord was resected. The cord was continuous to the anterior of the ileal mesentery about 20 cm proximal from the ileocecal valve. No Meckel’s diverticulum was found. Histopathological examination revealed that the cord contained an artery and vein, and was diagnosed as vitelline vascular remnants. Vitelline vascular remnants without Meckel’s diverticulum are often found in the presence of ileus, making diagnostic imaging and preoperative diagnosis difficult. Prophylactic resection of vitelline vascular remnants may be desirable if a diagnosis can be made or if they are discovered by chance during surgery.</p>

    DOI: 10.5833/jjgs.2019.0138

    CiNii Research

  7. A Case of Remnant Pancreatic Carcinoma after Pancreatoduodenectomy for Bile Duct Carcinoma

    TAKAGI Takehiro, MORIOKA Jun, KOBAYASHI Satoshi, KOMAYA Kenichi, JINNO Takanori, HORI Akihiro

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)   Vol. 81 ( 2 ) page: 349 - 353   2020

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    Language:Japanese   Publisher:Japan Surgical Association  

    <p>We performed distal pancreatectomy with preservation of the pancreatic body for carcinoma of the remnant pancreas which was diagnosed 4 years and 8 months after pancreatoduodenectomy for bile duct carcinoma. The patient was a 75-year-old man undergone pancreatoduodenectomy for carcinoma of the inferior bile duct which was pathologically diagnosed as well-differentiated tubular adenocarcinoma Stage II. Four years and 8 months later, an increase in the CA19-9 level was noted. An abdominal CT scan showed a 2-cm poorly enhanced irregular-shaped tumor at the remnant pancreatic tail. The main pancreatic duct had dilated, and a granular shadow which seemed to be a pancreatic stone was confirmed in the main pancreatic duct in the vicinity of the pancreatojejunostomy. Pancreatic carcinoma in the remnant pancreas and chronic pancreatitis due to the pancreatic stone were diagnosed, and we performed distal pancreatectomy with preservation of the pancreatic body, splenectomy and lymph node dissection. At surgery, the jejunum was dissected and lifted at the distal aspect of the gastrojejunostomy, and jejunal anastomosis was made at the distal pancreatic stump as a drainage of the pancreatic duct for recurrent pancreatitis. The histopathological diagnosis was tubular adenocarcinoma Stage IB. After the operation, his blood-sugar level has been kept stable without using insulin. As metachronous remnant pancreatic carcinoma after resection of bile duct carcinoma is extremely rare, we present this case with some bibliographical comments.</p>

    DOI: 10.3919/jjsa.81.349

    CiNii Research

  8. Nerve Sparing Laparoscopic Sacrocolpopexy - from Colorectal Surgeon's View

    Kato Takehiro, Morioka Jun, Kobayashi Satoshi, Takagi Takehiro, Jinno Takanori, Akihiro Hori and

    Journal of Female Pelvic Floor Medicine   Vol. 16 ( 1 ) page: 3 - 8   2019.7

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    Language:Japanese   Publisher:Japanese Society of Female Felvic Floor Medicine  

    DOI: 10.32310/jfpfm.16.1_3

    CiNii Research

  9. 手術症例報告 ISR術後の腸管脱に対しDelorme手術を施行した1例

    神野 孝徳, 小林 聡, 久留宮 康浩

    手術   Vol. 72 ( 12 ) page: 1805 - 1808   2018.11

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    Publisher:金原出版  

    DOI: 10.18888/op.0000000937

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  10. A Case of Duodenal Gastrointestinal Stromal Tumor with Resected Local Recurrence 9 Years after Surgery

    JINNO Takanori, MORIOKA Jun, KOBAYASHI Satoshi, KATO Takehiro, TAKAGI Takehiro, HORI Akihiro

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)   Vol. 79 ( 9 ) page: 1864 - 1869   2018

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    Language:Japanese   Publisher:Japan Surgical Association  

    The patient was a 77-year-old man who underwent wedge resection of a gastrointestinal stromal tumor of the third portion of the duodenum in 2005. There was no recurrence, and follow-up observation was completed in 2011. He was found to have anemia and was referred to our hospital in 2014. Examination showed a tumor in the third portion of the duodenum. Partial duodenectomy was performed due to suspected local recurrence. Because histopathological examination showed a tissue image similar to that at the initial surgery, and it occurred near the previously resected area, local recurrence of the duodenal GIST was diagnosed. A review of the Japanese reports on duodenal GIST that caused late recurrence showed that, in cases with a low mitotic index and a large tumor size, there is a possibility of late recurrence, and long-term follow-up may be necessary. In principle, the treatment of recurrent GIST is imatinib, but there are cases in which the prognosis is expected to improve with resection, as in the present case. It is necessary to clarify the clinical picture of such cases to be able to select appropriate therapy in the future.

    DOI: 10.3919/jjsa.79.1864

    CiNii Research

  11. Perforation of Ileal Duplication Treated by Laparoscopic Surgery

    Jinno Takanori, Kurumiya Yasuhiro, Sekoguchi Ei, Kobayashi Satoshi, Kawai Kiyotaka, Kiriyama Muneyasu

    The Japanese Journal of Gastroenterological Surgery   Vol. 51 ( 4 ) page: 294 - 300   2018

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    Language:Japanese   Publisher:The Japanese Society of Gastroenterological Surgery  

    <p>A 74-year-old man presented with a complaint of abdominal pain. His abdomen showed muscular guarding with tenderness in the right lower quadrant and laboratory data showed a remarkable elevation of an inflammatory response. Abdominal CT showed thickness in the small intestinal wall and an abscess formation with an elevation of surrounding fat density in the right lower abdomen. We diagnosed peritonitis caused by perforation of a diverticulum of the small intestine and performed emergency laparoscopic surgery. A diverticulum was detected on the mesenteric side 30 cm proximal from the ileum end and the tip was perforated. The diverticulum resection was performed with partial ileal resection. Histopathological examination revealed the muscular layer and the mucosal lining of the diverticulum were continuous with those of the ileum. These findings yielded a diagnosis of ileal duplication. We report a rare case of a perforated ileal duplication.</p>

    DOI: 10.5833/jjgs.2017.0034

    CiNii Research

  12. Toxic Shock Syndrome Following Incisional Hernia Repair: A Case Report

    KATO Takehiro, MORIOKA Jun, TAKAGI Takehiro, SAKATOKU Yayoi, JINNO Takanori, HORI Akihiro

    JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE   Vol. 66 ( 1 ) page: 65 - 71   2017

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    Language:Japanese   Publisher:THE JAPANESE ASSOCIATION OF RURAL MEDICINE  

    We report the first case in the Japanese literature of toxic shock syndrome following incisional hernia repair. We performed incisional hernia repair in a 54-year-old man with a BMI of 32.6 kg/m2 who underwent sigmoidectomy for cancer of the sigmoid colon one and half years earlier. Postoperative course was complicated by subcutaneous hemorrhage, which resolved with conservative management, and he was discharged on the 9th postoperative day. However, 3 days after discharge, he was readmitted with shock, high fever, diarrhea, vomiting, somnolence, and acute renal failure. He was diagnosed with toxic shock syndrome (TSS) due to TSS toxin-1 produced by MRSA infection of the subcutaneous hematoma. Drainage was performed and vancomycin, clindamycin, and gamma-globulin therapy were administered, with intensive supportive care. Treatment was successful and he was discharged 24 days after admission.

    DOI: 10.2185/jjrm.66.65

    CiNii Research

  13. Accessory Breast Cancer of the Axilla: A Case Report

    KATO Takehiro, MORIOKA Jun, TAKAGI Takehiro, SAKATOKU Yayoi, JINNO Takanori, HORI Akihiro

    JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE   Vol. 66 ( 1 ) page: 72 - 78   2017

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    Language:Japanese   Publisher:THE JAPANESE ASSOCIATION OF RURAL MEDICINE  

    We report a case of accessory breast cancer in the right axillary region. A 67-year-old woman visited our department complaining of a lump in the right underarm. We suspected cancer of an accessory breast from the findings of mammography and ultrasonography; a histological diagnosis of breast cancer was obtained by needle biopsy. With a preoperative diagnosis of accessory
    breast cancer accompanied by ipsilateral axillary nodal involvement, the patient underwent wide local resection of the right axillary region with lymph-node dissection (level II). Histopathological findings of the resected specimen revealed that the tumor was composed of solid tubular carcinoma with intraductal component, with normal breast tissue in the region adjacent to the tumor. A diagnosis of right axillary accessory breast cancer (pT2, N1, pStage IIb) was confirmed. Postoperative chemotherapy and radiotherapy were administered. At present, 18 months after surgery, no sign of recurrence has been observed.

    DOI: 10.2185/jjrm.66.72

    CiNii Research

  14. Long Survival of Para-aortic Lymph Node Metastases Treated with Chemotherapy and Dissection Following Gastric Cancer Surgery

    Jinno Takanori, Kurumiya Yasuhiro, Sekoguchi Ei, Kobayashi Satoshi, Kawai Kiyotaka, Kiriyama Muneyasu

    The Japanese Journal of Gastroenterological Surgery   Vol. 50 ( 5 ) page: 364 - 371   2017

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    Language:Japanese   Publisher:The Japanese Society of Gastroenterological Surgery  

    <p>A 61-year-old man had undergone curative distal gastrectomy and D2 lymph node dissection for advanced gastric cancer. We administered postoperative chemotherapy with S-1. Twelve months after the operation, an abdominal CT scan showed a marked swelling of the para-aortic lymph node. Seven cycles of S-1+PAC and 6 cycles of S-1+DOC were carried out, but was changed to CPT-11+CDDP because of increased CEA values 9 months after the start of treatment. The CEA value was reduced after the change, the abdominal CT scan revealed that the para-aortic lymph node was smaller. Because PET revealed only a swelling of the para-aortic lymph node, we performed a para-aortic lymph node dissection, and the left renal vein combined resection 2 years from the initial surgery. We used postoperative chemotherapy with 3 cycles of CPT-11+CDDP, and observed. The patient is presently alive with no signs of recurrence after 5 years from the dissection. In para-aortic lymph node metastases of gastric cancer after surgery, because some cases have extended prognosis or are curative by dissection, it is necessary to accumulate and examine further cases related to adaptation and treatment strategy.</p>

    DOI: 10.5833/jjgs.2016.0081

    CiNii Research

  15. A Case of Type IIIb Pancreatic Trauma in which Surgery Could be Avoided by Pancreatic Drainage

    JINNO Takanori, KURUMIYA Yasuhiro, SEKOGUCHI Ei, KOBAYASHI Satoshi, KAWAI Kiyotaka, KIRIYAMA Muneyasu

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)   Vol. 77 ( 5 ) page: 1223 - 1228   2016

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    Language:Japanese   Publisher:Japan Surgical Association  

    A 60-year-old man who developed a bruise in the upper abdomen after he fell against an iron fence was admitted to our hospital. Abdominal CT scan showed injury of the head of the pancreas. Endoscopic retrograde pancreatography (ERP) showed no contrast medium leakage from the main pancreatic duct. We selected conservative treatment with an endoscopic nasopancreatic drainage (ENPD) tube placed in the main pancreatic duct. ENPD contrast examination on the second day showed contrast medium leakage from the main pancreatic duct at the pancreatic head. We diagnosed type IIIb pancreatic trauma, however, continued conservative treatment as the general condition of the patient was improving. The ENPD was exchanged for an endoscopic retrograde pancreatic drainage (ERPD) tube on the 25th day. The patient was discharged on the 36th day with the ERPD tube in place. The ERPD tube was removed after three months from the injury. A medical follow-up at 13 months revealed disappearance and absence of recurrence of the bruise.<BR>Surgical treatment may be avoided in some case with type IIIb pancreatic trauma by instituting pancreatic drainage. It is necessary to accumulate further evidence to establish a standard therapeutic strategy for type IIIb pancreatic trauma.

    DOI: 10.3919/jjsa.77.1223

    CiNii Research

  16. 腹腔鏡下脾嚢胞天蓋切除術を施行した糖鎖抗原19-9(CA19-9)高値脾嚢胞の1例

    神野 孝徳, 久留宮 康浩, 世古口 英, 小林 聡, 桐山 宗泰, 青山 広希

    外科   Vol. 77 ( 11 ) page: 1319 - 1321   2015.11

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    Publisher:南江堂  

    DOI: 10.15106/j00393.2016142691

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  17. A Case of Small Bowel Perforation due to Eosinophilic Gastroenteritis

    JINNO Takanori, KURUMIYA Yasuhiro, MIZUNO Keisuke, SEKOGUCHI Ei, KOBAYASHI Satoshi, KIRIYAMA Muneyasu

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)   Vol. 76 ( 12 ) page: 2984 - 2988   2015

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    Language:Japanese   Publisher:Japan Surgical Association  

    A 44-year-old man was admitted to our hospital with abdominal pain and vomiting. He had increased numbers of eosinophils in his peripheral blood. Lower gastrointestinal tract biopsy revealed inflammatory cell infiltration (mainly eosinophils). We initiated oral steroid therapy under a diagnosis of eosinophilic gastroenteritis. The patient's symptoms subsided and he experienced weight loss. He was then readmitted to our hospital with relapse. He complained of a severe abdominal pain on the 20<SUP>th</SUP> day from diagnosis. Computed tomography detected ascites and intraperitoneal free air in the abdomen, so we performed emergency surgery under a diagnosis of small bowel perforation. Abdominal cavity exploration confirmed perforation of the ileum at a site 30 cm from the distal ileum. Histopathological examination of the ileum revealed inflammatory cell infiltration (mainly eosinophils) around the perforation site, and we made a diagnosis of small bowel perforation due to eosinophilic gastroenteritis. One year after surgery, the patient has experienced no relapse.<BR>Eosinophilic gastroenteritis can frequently relapse, sometimes causing gastrointestinal perforation. Therefore, appropriate maintenance treatment is important.

    DOI: 10.3919/jjsa.76.2984

    CiNii Research

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MISC 3

  1. Loss of Trefoil Factor 1 Accelerates the Immune Response to Colorectal Cancer

    Jinno, T; Yamaguchi, J; Ogura, A; Kokuryo, T; Yokoyama, Y; Sunagawa, M; Baba, T; Murata, Y; Ebata, T

    ANTICANCER RESEARCH   Vol. 44 ( 9 ) page: 3757 - 3769   2024.9

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    Language:English   Publisher:Anticancer Research  

    Background/Aim: Recent studies suggest that PD-L1 expression in immune cells, rather than tumor cells, plays a key role in tumor immunity. Trefoil factor family 1 (TFF1) is a secreted protein expressed mainly by the gastrointestinal epithelium and is related to the development of malignant disease. This study investigated the effects of TFF1 on tumor immunity in a xenograft mouse model of colorectal cancer (CRC). Materials and Methods: MC38 cells were implanted in wild-type (WT) and TFF1KO mice, and the tumor microenvironment was investigated using immunohistochemistry. The circulating immune cells were analyzed using flow cytometry. Results: Tumor growth was suppressed in TFF1KO mice. In the tumor microenvironment, CD8- and CD4-positive T cells and CD11c-positive dendritic cells (DCs) were frequently found in TFF1KO mice. When an immune checkpoint inhibitor was administered to these mice, almost half of the tumors in TFF1KO mice showed a complete response. The number of circulating PD-L1/DCs was markedly associated with tumor volume, with TFF1 deletion accelerating this effect and its injection decreasing it. These findings indicate that loss of TFF1 activates tumor immunity via frequent T-cell priming by DCs, and eventually suppresses tumor growth in CRC. In addition, the number of circulating PD-L1/DCs was identified as a predictive marker of checkpoint-inhibiting therapy efficacy. Conclusion: Loss of TFF1 resulted in accelerated immune response to colorectal cancer. Further studies are needed to investigate the precise mechanisms of TFF1 in immunotolerance and develop a novel TFF1-inhibiting immunotherapeutic strategy for CRC.

    DOI: 10.21873/anticanres.17200

    Web of Science

    Scopus

    PubMed

  2. Two-team laparoscopic extended lateral lymph node dissection with transperineal resection of the distal main trunk of internal iliac vein using a linear stapler-A video vignette

    Murata, Y; Ogura, A; Jinno, T; Yogo, K; Mizuno, T; Ebata, T

    COLORECTAL DISEASE     2024.8

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    Language:English   Publisher:Colorectal Disease  

    DOI: 10.1111/codi.17129

    Web of Science

    Scopus

    PubMed

  3. Usefulness of fluorescent ureteral navigation in total pelvic exenteration using a two-team approach for locally recurrent pelvic malignancies-A video vignette

    Ogura, A; Murata, Y; Jinno, T; Yoshikawa, N; Kajiyama, H; Ebata, T

    COLORECTAL DISEASE     2024.2

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    Publisher:Colorectal Disease  

    DOI: 10.1111/codi.16897

    Web of Science

    Scopus

    PubMed

Presentations 6

  1. A Case of Remnant Pancreatic Carcinoma after Pancreatoduodenectomy for Bile Duct Carcinoma

    TAKAGI Takehiro, MORIOKA Jun, KOBAYASHI Satoshi, KOMAYA Kenichi, JINNO Takanori, HORI Akihiro

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)  2020  Japan Surgical Association

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    Language:Japanese  

    <p>We performed distal pancreatectomy with preservation of the pancreatic body for carcinoma of the remnant pancreas which was diagnosed 4 years and 8 months after pancreatoduodenectomy for bile duct carcinoma. The patient was a 75-year-old man undergone pancreatoduodenectomy for carcinoma of the inferior bile duct which was pathologically diagnosed as well-differentiated tubular adenocarcinoma Stage II. Four years and 8 months later, an increase in the CA19-9 level was noted. An abdominal CT scan showed a 2-cm poorly enhanced irregular-shaped tumor at the remnant pancreatic tail. The main pancreatic duct had dilated, and a granular shadow which seemed to be a pancreatic stone was confirmed in the main pancreatic duct in the vicinity of the pancreatojejunostomy. Pancreatic carcinoma in the remnant pancreas and chronic pancreatitis due to the pancreatic stone were diagnosed, and we performed distal pancreatectomy with preservation of the pancreatic body, splenectomy and lymph node dissection. At surgery, the jejunum was dissected and lifted at the distal aspect of the gastrojejunostomy, and jejunal anastomosis was made at the distal pancreatic stump as a drainage of the pancreatic duct for recurrent pancreatitis. The histopathological diagnosis was tubular adenocarcinoma Stage IB. After the operation, his blood-sugar level has been kept stable without using insulin. As metachronous remnant pancreatic carcinoma after resection of bile duct carcinoma is extremely rare, we present this case with some bibliographical comments.</p>

    DOI: 10.3919/jjsa.81.349

    CiNii Research

  2. A Case of Type IIIb Pancreatic Trauma in which Surgery Could be Avoided by Pancreatic Drainage

    JINNO Takanori, KURUMIYA Yasuhiro, SEKOGUCHI Ei, KOBAYASHI Satoshi, KAWAI Kiyotaka, KIRIYAMA Muneyasu

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)  2016  Japan Surgical Association

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    Language:Japanese  

    A 60-year-old man who developed a bruise in the upper abdomen after he fell against an iron fence was admitted to our hospital. Abdominal CT scan showed injury of the head of the pancreas. Endoscopic retrograde pancreatography (ERP) showed no contrast medium leakage from the main pancreatic duct. We selected conservative treatment with an endoscopic nasopancreatic drainage (ENPD) tube placed in the main pancreatic duct. ENPD contrast examination on the second day showed contrast medium leakage from the main pancreatic duct at the pancreatic head. We diagnosed type IIIb pancreatic trauma, however, continued conservative treatment as the general condition of the patient was improving. The ENPD was exchanged for an endoscopic retrograde pancreatic drainage (ERPD) tube on the 25th day. The patient was discharged on the 36th day with the ERPD tube in place. The ERPD tube was removed after three months from the injury. A medical follow-up at 13 months revealed disappearance and absence of recurrence of the bruise.<BR>Surgical treatment may be avoided in some case with type IIIb pancreatic trauma by instituting pancreatic drainage. It is necessary to accumulate further evidence to establish a standard therapeutic strategy for type IIIb pancreatic trauma.

    DOI: 10.3919/jjsa.77.1223

    CiNii Research

  3. 腹腔鏡下脾嚢胞天蓋切除術を施行した糖鎖抗原19-9(CA19-9)高値脾嚢胞の1例

    神野 孝徳, 久留宮 康浩, 世古口 英, 小林 聡, 桐山 宗泰, 青山 広希

    外科  2015.11.1  南江堂

  4. A Case of Duodenal Gastrointestinal Stromal Tumor with Resected Local Recurrence 9 Years after Surgery

    JINNO Takanori, MORIOKA Jun, KOBAYASHI Satoshi, KATO Takehiro, TAKAGI Takehiro, HORI Akihiro

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)  2018  Japan Surgical Association

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    Language:Japanese  

    The patient was a 77-year-old man who underwent wedge resection of a gastrointestinal stromal tumor of the third portion of the duodenum in 2005. There was no recurrence, and follow-up observation was completed in 2011. He was found to have anemia and was referred to our hospital in 2014. Examination showed a tumor in the third portion of the duodenum. Partial duodenectomy was performed due to suspected local recurrence. Because histopathological examination showed a tissue image similar to that at the initial surgery, and it occurred near the previously resected area, local recurrence of the duodenal GIST was diagnosed. A review of the Japanese reports on duodenal GIST that caused late recurrence showed that, in cases with a low mitotic index and a large tumor size, there is a possibility of late recurrence, and long-term follow-up may be necessary. In principle, the treatment of recurrent GIST is imatinib, but there are cases in which the prognosis is expected to improve with resection, as in the present case. It is necessary to clarify the clinical picture of such cases to be able to select appropriate therapy in the future.

    DOI: 10.3919/jjsa.79.1864

    CiNii Research

  5. 手術症例報告 ISR術後の腸管脱に対しDelorme手術を施行した1例

    神野 孝徳, 小林 聡, 久留宮 康浩

    手術  2018.11.15  金原出版

  6. A Case of Small Bowel Perforation due to Eosinophilic Gastroenteritis

    JINNO Takanori, KURUMIYA Yasuhiro, MIZUNO Keisuke, SEKOGUCHI Ei, KOBAYASHI Satoshi, KIRIYAMA Muneyasu

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)  2015  Japan Surgical Association

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    Language:Japanese  

    A 44-year-old man was admitted to our hospital with abdominal pain and vomiting. He had increased numbers of eosinophils in his peripheral blood. Lower gastrointestinal tract biopsy revealed inflammatory cell infiltration (mainly eosinophils). We initiated oral steroid therapy under a diagnosis of eosinophilic gastroenteritis. The patient's symptoms subsided and he experienced weight loss. He was then readmitted to our hospital with relapse. He complained of a severe abdominal pain on the 20<SUP>th</SUP> day from diagnosis. Computed tomography detected ascites and intraperitoneal free air in the abdomen, so we performed emergency surgery under a diagnosis of small bowel perforation. Abdominal cavity exploration confirmed perforation of the ileum at a site 30 cm from the distal ileum. Histopathological examination of the ileum revealed inflammatory cell infiltration (mainly eosinophils) around the perforation site, and we made a diagnosis of small bowel perforation due to eosinophilic gastroenteritis. One year after surgery, the patient has experienced no relapse.<BR>Eosinophilic gastroenteritis can frequently relapse, sometimes causing gastrointestinal perforation. Therefore, appropriate maintenance treatment is important.

    DOI: 10.3919/jjsa.76.2984

    CiNii Research

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