Faculty Profiles - IYOSHI Shohei

写真a

IYOSHI Shohei

Organization

Institute for Advanced Research Designated Assistant Professor
Graduate School of Medicine Designated Assistant Professor

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Degree 4

Doctor of Philosophy in Medical Science （ 2022.11 Nagoya University ）
Bachelor of Medical Doctor （ 2015.3 Nagoya University ）
Master of Science in Human Environment Studies （ 2009.3 Kyoto University ）
Bachelor of Integrated Human Studies （ 2007.3 Kyoto University ）

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Research Interests 7

Reproductive medicine
Clinical Proteomics
Lipid Droplet
Cancer Biology
Gynecologic Oncology
Chemical Biology
Reproductive medicine

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Research Areas 2

Life Science / Obstetrics and gynecology
Nanotechnology/Materials / Chemical biology

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Current Research Project and SDGs 1

LipoQuality in women’s health care

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Research History 8

Nagoya University Institute for Advanced Research / Graduate School of Medicine YLC Designated Assistant Professor

2023.4

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Country：Japan

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Gifu Prefectural Tajimi Hospital Department of Obstetrics and Gynecology

2022.10 - 2023.3

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Country：Japan

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Nagoya University Hospital Department of Obstetrics and Gynecology

2022.8 - 2022.9

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Country：Japan

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DAAD Research Grants - Bi-nationally Supervised Doctoral Degrees / Cotutelle

2020.10 - 2022.7

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Country：Germany

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Nagoya University Hospital Department of Obstetrics and Gynecology

2018.7 - 2020.9

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Country：Japan

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Gifu Prefectural Tajimi Hospital Department of Obstetrics and Gynecology

2017.4 - 2018.6

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Country：Japan

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TOYOTA Memorial Hospital

2015.4 - 2017.3

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Country：Japan

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JSPS Research Fellowship for Young Scientists (DC1)

2009.4 - 2011.3

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Country：Japan

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Education 6

Nagoya University Graduate School of Medicine International Collaborative Program in Comprehensive Medical Science between Nagoya University and the University of Freiburg

2018.4 - 2023.11

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Country： Japan

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Albert-Ludwigs-Universität Freiburg Spemann Graduate School of Biology and Medicine

2020.10 - 2022.7

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Country： Germany

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Nagoya University School of Medicine Department of Medicine

2011.4 - 2015.3

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Country： Japan

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Kyoto University Graduate School of Human and Environmental Studies Department of Interdisciplinary Environment

2009.4 - 2011.3

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Country： Japan

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Kyoto University Graduate School of Human and Environmental Studies Department of Interdisciplinary Environment

2007.4 - 2009.3

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Country： Japan

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Kyoto University Department of Integrated Human Studies Division of Natural Sciences

2003.4 - 2007.3

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Country： Japan

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Papers 112

Mesothelial cells promote peritoneal invasion and metastasis of ascites-derived ovarian cancer cells through spheroid formation Open Access

Tomohiro Kanayama, Kazuhisa Kitami, Satoshi Tamauchi, Yoshihiro Koya, Kosuke Yoshida, Akira Yokoi, Kaname Uno, Masato Yoshihara, Yoshihiko Yamakita, Shohei Iyoshi, Mai Sugiyama, Haruhito Sahara, Satoshi Nomura, Kazumasa Mogi, Emiri Miyamoto, Nobuhisa Yoshikawa, Atsushi Enomoto, Kaoru Niimi, Akihiro Nawa, Hiroki Fujimoto, Hidenori Oguchi, Hiroaki Kajiyama, Kristian Pietras, Jonas Sjölund, Yukihiro Shiraki, Hiroyuki Tomita

Science Advances Vol. 12 ( 6 ) page： eadu5944 2026.2

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DOI： 10.1126/sciadv.adu5944

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Application of multimodal integration to develop preoperative diagnostic models for borderline and malignant ovarian tumors Open Access

Atsushi Kunishima, Daiki Inaba, Shohei Iyoshi, Yoshiki Ikeda, Mayuko Goto, Reina Muramatsu, Mizuki Hashimoto, Kosuke Yoshida, Kazumasa Mogi, Masato Yoshihara, Yukari Nagao, Satoshi Tamauchi, Akira Yokoi, Nobuhisa Yoshikawa, Kaoru Niimi, Norihiro Koizumi, Hiroaki Kajiyama

Scientific Reports Vol. 15 ( 1 ) page： 37114 2025.10

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Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1038/s41598-025-21128-w

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Other Link： https://www.nature.com/articles/s41598-025-21128-w
腹腔鏡下RRSO施行後に両側卵管癌を偶発的に認めたBRCA1陽性HBOCの1例

荒木甫, 芳川修久, 茂木一将, 玉内学志, 伊吉祥平, 吉田康将, 吉原雅人, 長尾有佳里, 横井暁, 新美薫, 梶山広明

愛知産科婦人科学会学術講演会プログラム Vol. 122回 page： np7 - np7 2025.10

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Development and Validation of Predictive Risk Scores for Ovarian Clear Cell Carcinoma: A Penalized Regression Model. International journal Open Access

Shohei Iyoshi, Ryo Emoto, Nobuhisa Yoshikawa, Kosuke Yoshida, Masato Yoshihara, Satoshi Tamauchi, Akira Yokoi, Yusuke Shimizu, Yoshiki Ikeda, Kaoru Niimi, Michiyasu Kawai, Shigeyuki Matsui, Hiroaki Kajiyama

Cancer medicine Vol. 14 ( 15 ) page： e71118 2025.8

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BACKGROUND: The precision management of ovarian clear cell carcinoma (OCCC) faces limitations due to the absence of personalized prognostic tools. This study aimed to establish predictive risk scores to enable effective stratification and tailored treatment of OCCC. METHODS: Retrospective data from 206 OCCC patients treated between 2004 and 2019 at two hospitals were analyzed. Penalized regression models were utilized to develop three risk scores based on preoperative laboratory results and intraoperative findings. These scores underwent internal and external validation. RESULTS: The median follow-up periods were 65.7 and 44.0 months for the derivation and validation cohorts, respectively. In internal validation with the derivation cohort, all three risk scores effectively identified the high-risk group for tumor recurrence. Upon validation with the external cohort, Risk Score 3, which incorporated variables selected in most cross-validations by the penalized regression (Elastic Net), distinctly differentiated the high- and low-risk groups (p = 0.03). Risk Score 2, consisting solely of preoperatively available variables, also demonstrated marginal significance (p = 0.08). CONCLUSION: Our findings underscore the significance and utility of the developed risk scores in tailoring personalized treatments for patients with OCCC.

DOI： 10.1002/cam4.71118

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Neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancer. International journal Open Access

Emiri Miyamoto, Masato Yoshihara, Shohei Iyoshi, Kazumasa Mogi, Kaname Uno, Hiroki Fujimoto, Yoshihiro Koya, Kazuhisa Kitami, Kosuke Yoshida, Satoshi Tamauchi, Akira Yokoi, Nobuhisa Yoshikawa, Kaoru Niimi, Hiroyuki Tomita, Hiroyasu Kidoya, Yukihiro Shiraki, Atsushi Enomoto, Hiroaki Kajiyama

Scientific reports Vol. 15 ( 1 ) page： 23196 - 23196 2025.7

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The impact on prognosis of neutrophil infiltration in the microenvironment of ovarian cancer remains to be elucidated. In this study, we analyzed the association between neutrophil infiltration in peritoneal metastasis and prognosis. Furthermore, we analyzed the correlation between neutrophil infiltration in peritoneal metastasis and the number of peripheral blood neutrophils, the degree of neutropenia, vascular endothelial area, and the number of stromal cells. Thirty-four specimens each of primary and metastatic advanced ovarian cancer with high-grade serous carcinoma histology were taken. Staining for MPO, CD31, and αSMA was performed on all specimens. We investigated the correlation among tissue neutrophil infiltration, prognosis, and neutrophil indicators from blood tests. Survival analysis showed that neutrophil infiltration in the primary tumor had no impact on prognosis, whereas high neutrophil infiltration in the disseminated tumor significantly shortened progression-free survival and overall survival. No correlation was found between neutrophil infiltration and the number of peripheral blood neutrophils, the degree of neutropenia, area of vascular endothelial cells, and number of stromal cells. Neutrophil infiltration into disseminated lesions of the omentum has a significant impact on prognosis. The results of the present study may provide insights for refining clinical approaches.

DOI： 10.1038/s41598-025-05010-3

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進行卵巣癌腹膜播種における好中球浸潤が予後へ及ぼす影響

宮本絵美里, 吉原雅人, 伊吉祥平, 茂木一将, 宇野枢, 藤本裕基, 北見和久, 吉田康将, 玉内学志, 横井暁, 芳川修久, 新美薫, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 67回 page： 246 - 246 2025.7

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血液検査とMRI画像の学習モデル統合によるAI援用卵巣腫瘍術前診断支援システムの開発

國島温志, 稲葉大樹, 池田芳紀, 伊吉祥平, 後藤万由子, 橋本瑞樹, 村松令糸生, 吉田康将, 茂木一将, 吉原雅人, 長尾有佳里, 玉内学志, 横井暁, 芳川修久, 新美薫, 小泉憲裕, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 67回 page： 266 - 266 2025.7

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漢方補剤はPARP阻害薬の骨髄抑制管理に有用である

尾崎香菜子, 芳川修久, 松川哲也, 伊吉祥平, 吉田康将, 吉原雅人, 長尾有佳里, 玉内学志, 横井暁, 新美薫, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 67回 page： 326 - 326 2025.7

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子宮体癌の予後に関する血清バイオマーカーについての検討

窪川芽衣, 芳川修久, 片山高明, 松川哲也, 服部諭美, 伊吉祥平, 吉田康将, 茂木一将, 吉原雅人, 玉内学志, 横井暁, 新美薫, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 67回 page： 251 - 251 2025.7

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卵巣がんの腹膜転移における中皮細胞グリコカリックスの役割

茂木一将, 宮本絵美里, 國島温志, 藤本裕基, 伊吉祥平, 吉原雅人, 吉田康将, 長尾有佳里, 玉内学志, 横井暁, 芳川修久, 新美薫, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 67回 page： 333 - 333 2025.7

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リスク層別化を志向した卵巣明細胞癌予後スコアの開発と検証正則化回帰モデルを用いたアプローチ

伊吉祥平, 芳川修久, 吉原雅人, 宮本絵美里, 藤本裕基, 國島温志, 茂木一将, 北見和久, 宇野枢, 吉田康将, 玉内学志, 長尾有佳里, 横井暁, 新美薫, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 67回 page： 224 - 224 2025.7

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Tumor growth direction predicts surgical difficulty in large uterine fibroids: A retrospective imaging-based study. International journal

Satoshi Tamauchi, Kaoru Niimi, Shohei Iyoshi, Kosuke Yoshida, Kazumasa Mogi, Masato Yoshihara, Yukari Nagao, Akira Yokoi, Nobuhisa Yoshikawa, Hiroaki Kajiyama

The journal of obstetrics and gynaecology research Vol. 51 ( 7 ) page： e70013 2025.7

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OBJECTIVE: To identify preoperative imaging features associated with retroperitoneal growth of large uterine fibroids and evaluate their impact on surgical outcomes. METHODS: This retrospective study included 20 patients who underwent hysterectomy for uterine fibroids measuring ≥10 cm between 2014 and 2024. Preoperative CT or MRI was evaluated for four features: bladder displacement, sigmoid colon deviation, cecal displacement, and hydronephrosis. Tumor growth direction (intraperitoneal vs. retroperitoneal) was determined intraoperatively. Operative time, blood loss, and complications were compared between groups. RESULTS: Eight tumors exhibited retroperitoneal growth. Bladder displacement, cecal shift, sigmoid colon deviation, and hydronephrosis were significantly more common in retroperitoneal cases (all p < 0.05). Retroperitoneal tumors were associated with significantly greater median blood loss (1591 mL vs. 651 mL, p = 0.043), although operative time did not differ significantly (301 vs. 232 min, p = 0.237). Organ injury or resection occurred only in the retroperitoneal group. A bubble plot illustrated the trend of increased surgical burden in retroperitoneal cases. CONCLUSION: Retroperitoneal growth of large uterine fibroids is associated with increased intraoperative blood loss and surgical complexity. Four simple imaging features may serve as reliable indicators of growth direction and help guide preoperative planning.

DOI： 10.1111/jog.70013

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p53変異子宮体癌における免疫環境とCD47発現の解析

松川哲也, 芳川修久, 服部諭美, 窪川芽衣, 片山高明, 長尾有佳里, 茂木一将, 伊吉祥平, 吉田康将, 吉原雅人, 玉内学志, 横井暁, 新美薫, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 67回 page： 331 - 331 2025.7

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III期R0達成卵巣癌における腹水細胞診陽性の予後への影響

吉川麻里奈, 吉原雅人, 宮本絵美里, 國島温志, 藤本裕基, 茂木一将, 伊吉祥平, 吉田康将, 玉内学志, 横井暁, 芳川修久, 新美薫, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 67回 page： 223 - 223 2025.7

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Long-term prognostic significance of ascites cytology in ovarian cancer cases in which R0 resection was achieved in the initial surgery: a multi-institutional retrospective cohort study. International journal Open Access

Shohei Iyoshi, Mayuko Sunohara, Masato Yoshihara, Atsushi Kunishima, Emiri Miyamoto, Hiroki Fujimoto, Kazuhisa Kitami, Kazumasa Mogi, Kaname Uno, Kosuke Yoshida, Satoshi Tamauchi, Akira Yokoi, Kaoru Niimi, Nobuhisa Yoshikawa, Ryo Emoto, Shigeyuki Matsui, Hiroaki Kajiyama

Japanese journal of clinical oncology Vol. 55 ( 7 ) page： 743 - 750 2025.3

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BACKGROUND: In ovarian cancer (OvCa), achieving complete resection (RO) in initial surgery is crucial for improving prognosis. However, patients with undetected microscopic metastasis post-RO surgery often have poorer outcomes. This study explores prognostic factors for OvCa patients who underwent RO surgery, focusing on the role of ascites cytology as an indicator of microscopic peritoneal metastasis. METHODS: We analyzed data from 975 OvCa cases in the Tokai Ovarian Tumor Study Group database (1986-2019). Excluding patients without chemotherapy or with distant metastasis, we examined prognostic factors using Cox regression analysis. Propensity score (PS) methods balanced the cytology-positive and -negative groups, with subgroup analysis for clinical stage and ascites volume. RESULTS: Multivariate analysis identified FIGO stage III and positive ascites cytology as poor prognostic factors for overall and progression-free survival. After PS adjustment, positive ascites cytology also shortened progression-free intervals post-recurrence, especially in cases with peritoneal or lymph node metastasis. Subgroup analysis revealed a more substantial prognostic impact of positive ascites cytology in early-stage cases. CONCLUSION: The present results suggest that in OvCa patients with the R0 status, the presence of tumor cells in ascites is an independent negative prognostic factor and may be an indicator of peritoneal micro-metastasis.

DOI： 10.1093/jjco/hyaf046

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Vitamin D derivatives inhibit mesenchymal transition of mesothelial cells and mitigate peritoneal dissemination of ovarian cancer.

Kazuhisa Fujita, Maia Hayashi, Masato Yoshihara, Satoshi Nomura, Kazuhisa Kitami, Emiri Miyamoto, Shohei Iyoshi, Kazumasa Mogi, Hiroki Fujimoto, Kaname Uno, Atsushi Kunishima, Yoshihiko Yamakita, Hiroyuki Tomita, Rino Tsutsumi, Ryota Sakamoto, Kazuo Nagasawa, Yusuke Masuo, Takumi Nishiuchi, Kiyosumi Shibata, Atsushi Enomoto, Hiroaki Kajiyama

Medical molecular morphology Vol. 58 ( 3 ) page： 171 - 182 2025.2

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Ovarian cancer (OvCa) is a leading cause of gynecological cancer-related mortality, primarily due to peritoneal dissemination, which facilitates metastasis in the abdominal cavity. This study explored the potential of vitamin D and its synthetic derivatives in mitigating peritoneal dissemination by modulating the behavior of mesothelial cells (MCs). Vitamin D, through its receptor (VDR), is known to influence cancer progression, and our findings demonstrate that vitamin D derivatives can inhibit mesenchymal transition of MCs induced by TGF-β1, a key driver of peritoneal dissemination. This study used patient-derived primary MCs and in vivo mouse model to assess the effects of vitamin D derivatives on cell morphology, gene expression, and OvCa cell adhesion. Two vitamin D derivatives, VDR agonist, showed significant efficacy in maintaining epithelial-like MC morphology, reducing TGF-β1-induced changes, and inhibiting OvCa cell adhesion to the peritoneum, similar to calcitriol. Conversely, the VDR antagonist derivative induced MC apoptosis, highlighting the essential role of vitamin D in MC survival. These findings suggest that vitamin D derivatives could serve as promising therapeutic agents for OvCa by preserving peritoneal homeostasis and preventing metastasis. Further research is required to explore a broader range of derivatives and their underlying molecular mechanisms.

DOI： 10.1007/s00795-025-00424-4

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成熟奇形腫悪性転化の患者腫瘍由来モデル2種類を用いたPARP阻害薬の有効性の実証

中川敦史, 玉内学志, 茂木一将, 伊吉祥平, 吉田康将, 吉原雅人, 横井暁, 芳川修久, 新美薫, 梶山広明

日本産科婦人科学会雑誌 Vol. 77 ( 臨増 ) page： S - 448 2025.2

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Detailed analysis of the histology-specific impact of ascites volume on the outcome of epithelial ovarian cancer: a multi-institutional retrospective cohort study. International journal Open Access

Shohei Iyoshi, Mariko Kimura, Masato Yoshihara, Atsushi Kunishima, Emiri Miyamoto, Hiroki Fujimoto, Kazuhisa Kitami, Kazumasa Mogi, Kaname Uno, Sho Tano, Nobuhisa Yoshikawa, Ryo Emoto, Shigeyuki Matsui, Hiroaki Kajiyama

BMC cancer Vol. 24 ( 1 ) page： 1479 - 1479 2024.11

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BACKGROUND: The accumulation of ascites is a major symptom of ovarian cancer. The volume of ascites is a pathophysiological indicator of the peritoneal environment, such as inflammation and fibrosis; however, the relationship between the volume of ascites and oncological outcomes remains unclear. We herein retrospectively examined the effects of the volume of ascites on the prognosis of epithelial ovarian cancer in a multi-institutional large cohort using the stratification of clinical characteristics and statistical adjustment methods. METHODS: Of 5,268 patients with ovarian tumors in the Tokai Ovarian Tumor Study Group between 1986 and 2020, we included 1,966 cases of epithelial ovarian cancer and examined the relationship between the volume of ascites at the initial surgery and the prognosis of patients. We performed a multivariate analysis and propensity score weighting for covariate adjustments to precisely estimate the prognostic impact of ascites accumulation. A subgroup analysis was also performed to examine differences in the prognostic implications of ascites accumulation among histotypes. RESULTS: A reservoir of 100 mL of ascites was confirmed as the cut-off value in our cohort. A Kaplan-Meyer analysis with propensity score adjustments indicated that the accumulation of more than 100 mL of ascites shortened overall survival. The multivariate analysis revealed that the increased accumulation of 100 mL of ascites was an independent prognostic factor for overall survival (HR 1.242; 95% CI 1.050-1.470; P = 0.012). The subgroup analysis showed the prognostic significance of ascites accumulation in mucinous and endometrioid histologies. CONCLUSIONS: The accumulation of even a low to intermediate volume of ascites (≥ 100 mL) was confirmed to be an independent poor prognostic factor in epithelial ovarian cancer. Furthermore, its prognostic impact differed among histotypes.

DOI： 10.1186/s12885-024-13218-1

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Aging affects regrowth of stealthperitoneal dissemination of advanced ovarian cancer: a multicenter retrospective cohort study. International journal Open Access

Hiroki Fujimoto, Masato Yoshihara, Carmela Ricciardelli, Sho Tano, Shohei Iyoshi, Emiri Miyamoto, Kazumasa Mogi, Maia Hayashi, Sae Hayakawa, Satoshi Nomura, Kazuhisa Kitami, Kaname Uno, Nobuhisa Yoshikawa, Ryo Emoto, Shigeyuki Matsui, Hiroaki Kajiyama

Scientific reports Vol. 14 ( 1 ) page： 23537 - 23537 2024.10

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Ovarian cancer (OvCa) is one of the most lethal gynecological malignancies, and most patients are diagnosed at advanced stage with peritoneal dissemination. Although age at diagnosis is considered an independent prognostic factor, its impact on peritoneal recurrence after combined cytoreductive surgery and chemotherapy is not clear. The objective of this study was to investigate the impact of aging on peritoneal recurrence from stealth dissemination and gain insight of the pathophysiology of OvCa in elderly patients. A total of 243 patients with pT2b-pT3 epithelial ovarian who achieved complete surgery, no-residual tumor at first surgery, were selected to be analyzed the risk of peritoneal seeding and recurrence. We found that age over 65 years was independently associated with an increased risk of peritoneum-specific (PS) recurrence (. Furthermore, pT3 stages and positive ascites cytology also worsen the PS-relapse-free survival. Collectively, our findings suggest that age, especially over 65 years, predicts reduced peritoneum-specific tumor recurrence in patients with advanced ovarian cancer after complete cytoreduction surgery, particularly those with pT3 tumors and positive ascites cytology.

DOI： 10.1038/s41598-024-66419-w

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Factors affecting the long-term prognosis of patients in the AYA generation with epithelial ovarian cancer: A multicenter propensity score matching analysis. International journal Open Access

Emiri Miyamoto, Masato Yoshihara, Shohei Iyoshi, Kazumasa Mogi, Kaname Uno, Hiroki Fujimoto, Kazuhisa Kitami, Nobuhisa Yoshikawa, Hiroaki Kajiyama

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Vol. 166 ( 3 ) page： 1225 - 1231 2024.4

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OBJECTIVE: Ovarian carcinoma (OvCa) is more common in the elderly, but also affects the adolescent and young adult (AYA) generation, which refers to those aged 15-39 years. Although the characteristics of OvCa may differ between AYAs and non-AYAs, limited information is currently available on differences in prognostic factors. Therefore, we herein investigated prognostic factors for and the prognosis of OvCa in AYAs. We also examined the prognostic impact of fertility-sparing surgery in a subgroup analysis. METHODS: We retrospectively collected data on 4897 patients with OvCa from the databases of multiple institutions and ultimately included 1161 patients with epithelial ovarian cancer (EOC). We performed a survival analysis to compare AYAs and non-AYAs with backgrounds that conformed to those of AYAs using the propensity score (PS) matching method. A Cox regression analysis was also conducted to evaluate each predictor of recurrence-free survival (RFS) and overall survival (OS) in the original population. As a subgroup analysis, a multivariate analysis stratified by the AYA and non-AYA generations was performed. RESULTS: In total, 119 AYA patients were included in this study. After PS adjustments, no significant differences were observed in RFS or OS between AYAs and non-AYAs. Prognostic factors differed between AYAs and non-AYAs, particularly in histology and cytology. A multivariate analysis stratified by the AYA and non-AYA generations described that uterine-preserving surgery (UPS) did not have a significant impact on the prognosis of AYAs or non-AYAs. In cases with recurrence, no significant differences were observed in RFS and recurrent sites in the two groups. CONCLUSION: Characteristic prognostic factors for EOC in AYAs were identified. The present results indicate the limited prognostic impact of UPS for EOC in AYAs.

DOI： 10.1002/ijgo.15479

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Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination. International journal Open Access

Hiroki Fujimoto, Masato Yoshihara, Raymond Rodgers, Shohei Iyoshi, Kazumasa Mogi, Emiri Miyamoto, Sae Hayakawa, Maia Hayashi, Satoshi Nomura, Kazuhisa Kitami, Kaname Uno, Mai Sugiyama, Yoshihiro Koya, Yoshihiko Yamakita, Akihiro Nawa, Atsushi Enomoto, Carmela Ricciardelli, Hiroaki Kajiyama

Cancer metastasis reviews Vol. 43 ( 3 ) page： 1037 - 1053 2024.3

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Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge. Further development in this field will lead to new strategies to treat EOC. In this review, we focus on the recent findings on how the TAF contributes to EOC malignancy. Furthermore, we will review the recent initiatives and future therapeutic strategies for targeting TAF in EOC.

DOI： 10.1007/s10555-024-10169-8

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An update of oncologic and obstetric outcomes of radical trachelectomy for early-stage cervical cancer: The need for further minimally invasive treatment. International journal

Satoshi Tamauchi, Shohei Iyoshi, Masato Yoshihara, Kosuke Yoshida, Yoshiki Ikeda, Yusuke Shimizu, Akira Yokoi, Kaoru Niimi, Nobuhisa Yoshikawa, Hiroaki Kajiyama

The journal of obstetrics and gynaecology research Vol. 50 ( 2 ) page： 175 - 181 2024.2

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AIMS: To investigate the oncologic and obstetric outcomes of radical trachelectomy (RT) in patients with early-stage cervical cancer and to evaluate the potential role of fertility-preserving treatments in improving pregnancy outcomes while oncologic status is stable. METHODS: In this single-institution study, we analyzed the oncologic and obstetric outcomes of 67 patients with early-stage cervical cancer who underwent RT at Nagoya University Hospital. RESULTS: The cancer recurrence rate (6.0%) and the mortality rate (1.5%) were comparable with those of previous studies. Of the 46 patients who attempted to conceive after RT, 19 (41.3%) became pregnant, and 16 gave birth. Of these 37.5% delivered at term, and delivery at less than 28 weeks of gestation occurred in 31.3% of pregnancies. CONCLUSIONS: RT is a viable treatment option for selected patients with early-stage cervical cancer. However, the use of less invasive techniques, such as conization/simple trachelectomy and pelvic lymph node dissection, may improve pregnancy outcomes while oncologic status is stable.

DOI： 10.1111/jog.15824

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Chondroitin Sulfate Proteoglycan 4 Provides New Treatment Approach to Preventing Peritoneal Dissemination in Ovarian Cancer. International journal Open Access

Kaname Uno, Yoshihiro Koya, Masato Yoshihara, Shohei Iyoshi, Kazuhisa Kitami, Mai Sugiyama, Emiri Miyamoto, Kazumasa Mogi, Hiroki Fujimoto, Yoshihiko Yamakita, Xinhui Wang, Akihiro Nawa, Hiroaki Kajiyama

International journal of molecular sciences Vol. 25 ( 3 ) page： 1626 2024.1

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Most epithelial ovarian cancer (EOC) patients are diagnosed with peritoneal dissemination. Cellular interactions are an important aspect of EOC cells when they detach from the primary site of the ovary. However, the mechanism remains underexplored. Our study aimed to reveal the role of chondroitin sulfate proteoglycan 4 (CSPG4) in EOC with a major focus on cell-cell interactions. We examined the expression of CSPG4 in clinical samples and cell lines of EOC. The proliferation, migration, and invasion abilities of the CSPG4 knockdown cells were assessed. We also assessed the role of CSPG4 in spheroid formation and peritoneal metastasis in an in vivo model using sh-CSPG4 EOC cell lines. Of the clinical samples, 23 (44.2%) samples expressed CSPG4. CSPG4 was associated with a worse prognosis in patients with advanced EOC. Among the EOC cell lines, aggressive cell lines, including ES2, expressed CSPG4. When CSPG4 was knocked down using siRNA or shRNA, the cell proliferation, migration, and invasion abilities were significantly decreased compared to the control cells. Proteomic analyses showed changes in the expression of proteins related to the cell movement pathways. Spheroid formation was significantly inhibited when CSPG4 was inhibited. The number of nodules and the tumor burden of the omentum were significantly decreased in the sh-CSPG4 mouse models. In the peritoneal wash fluid from mice injected with sh-CSPG4 EOC cells, significantly fewer spheroids were present. Reduced CSPG4 expression was observed in lymphoid enhancer-binding factor 1-inhibited cells. CSPG4 is associated with aggressive features of EOC and poor prognosis. CSPG4 could be a new treatment target for blocking peritoneal metastasis by inhibiting spheroid formation.

DOI： 10.3390/ijms25031626

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Histology-specific long-term oncologic outcomes in patients with epithelial ovarian cancer who underwent complete tumor resection: The implication of occult seeds after initial surgery. International journal Open Access

Kazumasa Mogi, Masato Yoshihara, Ryo Emoto, Emiri Miyamoto, Hiroki Fujimoto, Kaname Uno, Sho Tano, Shohei Iyoshi, Kazuhisa Kitami, Nobuhisa Yoshikawa, Shigeyuki Matsui, Hiroaki Kajiyama

PloS one Vol. 19 ( 11 ) page： e0311421 2024

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OBJECTIVE: Assessing the histology-specific prognosis of epithelial ovarian cancer (OvCa) is clinically challenging, especially in a patient population with a favorable prognosis. This study investigated the histology-specific long-term oncologic outcomes in OvCa patients who underwent complete tumor resection using a large-scale patient cohort form multiple institutions under a central pathological review system. METHODS: A regional multi-institutional study was conducted from 1986 to 2019. Of the 4,898 patients with ovarian tumors enrolled, 1,175 patients who underwent complete tumor resection were classified into three classes based on clinically important prognostic factors: stage, cytology, ascites volume. For each class category, the effect of histology types on recurrence-free survival, the site of recurrence, and post-recurrence survival was evaluated. RESULTS: Recurrence-free survival varied significantly across different histologies (P < 0.001). The risk of recurrence was higher in serous carcinoma compare to other histologies (P < 0.001). The site of tumor recurrence varied by the histology type. Multinominal logistic regression analysis revealed that mucinous histology had a significantly higher likelihood of developing recurrent tumors at distant sites from the peritoneum compared to other histologies (P = 0.002). Conversely, serous histology was associated with better post-recurrence survival (Log-rank P < 0.001). CONCLUSIONS: Long-term oncologic outcomes significantly differ by histology type in OvCa patients who have undergone complete tumor resection at the initial surgery. A careful evaluation of the clinical background is necessary for these patients, and further clinical research into individualized treatment approaches is essential.

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Mean platelet volume as a potential biomarker for survival outcomes in ovarian clear cell carcinoma.

Nobuhisa Yoshikawa, Tetsuya Matsukawa, Satomi Hattori, Shohei Iyoshi, Kosuke Yoshida, Masato Yoshihara, Satoshi Tamauchi, Yusuke Shimizu, Yoshiki Ikeda, Akira Yokoi, Kaoru Niimi, Michiyasu Kawai, Hiroaki Kajiyama

International journal of clinical oncology Vol. 28 ( 12 ) page： 1680 - 1689 2023.12

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OBJECTIVE: This study aimed to explore the prognostic value of mean platelet volume (MPV) in patients with ovarian clear cell carcinoma (OCCC) and evaluate the predictive performance of a random forest model incorporating MPV and other key clinicopathological factors. METHODS: A total of 204 patients with OCCC treated between January 2004 and December 2019 were retrospectively analyzed. Clinicopathological characteristics and preoperative laboratory data were collected, and survival outcomes were evaluated using the Kaplan-Meier method and Cox proportional hazards models. An optimal MPV cutoff was determined by receiver operating characteristic (ROC) curve analysis. A random forest model was then constructed using the identified independent prognostic factors, and its predictive performance was evaluated. RESULTS: The ROC analysis identified 9.3 fL as the MPV cutoff value for predicting 2-year survival. The MPV-low group had lower 5-year overall survival and progression-free survival rates than the MPV-high group (p = 0.003 and p = 0.034, respectively). High MPV emerged as an independent prognostic factor (p = 0.006). The random forest model, incorporating the FIGO stage, residual tumors, peritoneal cytology, and MPV, demonstrated robust predictive performance (area under the curve: 0.905). CONCLUSION: MPV is a promising prognostic indicator in OCCC. Lower MPV correlated with worse survival rates, advocating its potential utility in refining patient management strategies. The commendable predictive performance of the random forest model, integrating MPV and other significant prognostic factors, suggests a pathway toward enhanced survival prediction, thereby warranting further research.

DOI： 10.1007/s10147-023-02417-8

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9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins. International journal Open Access

Kazumasa Mogi, Yoshihiro Koya, Masato Yoshihara, Mai Sugiyama, Rika Miki, Emiri Miyamoto, Hiroki Fujimoto, Kazuhisa Kitami, Shohei Iyoshi, Sho Tano, Kaname Uno, Satoshi Tamauchi, Akira Yokoi, Yusuke Shimizu, Yoshiki Ikeda, Nobuhisa Yoshikawa, Kaoru Niimi, Yoshihiko Yamakita, Hiroyuki Tomita, Kiyosumi Shibata, Akihiro Nawa, Yutaka Tomoda, Hiroaki Kajiyama

Scientific reports Vol. 13 ( 1 ) page： 19208 - 19208 2023.11

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Mucosal human papillomavirus (HPV) subtypes 16 and 18 are causative agents of cervical cancer, a leading cause of cancer-related deaths among women worldwide. In Japan, eggplant calyx is a folk remedy used to treat common warts. 9-oxo-(10E,12E)-octadecadienoic acid, isolated from eggplant calyx, may have antitumor effects. This study investigated the antitumor effects of 9-oxo-(10E, 12Z)-octadecadienoic acid and 9-oxo-(10E,12E)-octadecadienoic acid (9-oxo-ODAs) on human cervical cancer cells. 9-oxo-ODAs suppressed the proliferation of human cervical cancer cell lines (HeLa, and SiHa) in a concentration-dependent manner (IC50 = 25-50 µM). FCM analysis revealed that 9-oxo-ODAs induced apoptosis. Transcriptome, proteomics, and enrichment analyses revealed that treatment with 9-oxo-ODAs significantly altered the cell cycle and p53 pathways and decreased cyclin-dependent kinase 1 (CDK1) protein expression. Real-time PCR analysis demonstrated that 9-oxo-ODAs reduced CDK1 mRNA expression in a concentration-dependent manner. In vitro, 9-oxo-ODAs reduced the HPV oncoprotein expression. In ex vivo human cervical cancer tissues, 9-oxo-ODAs decreased CDK1 expression and increased cleaved caspase 3, an apoptosis marker. Further, 9-oxo-ODAs showed the potential to suppressed metastatic formation and growth of cervical cancer in vivo. These findings suggest that 9-oxo-ODAs induce cell cycle arrest and apoptosis in HPV-positive human cervical cancer cells, and this process involves CDK1. Consequently, 9-oxo-ODAs may be potential therapeutic agents for cervical cancer.

DOI： 10.1038/s41598-023-44365-3

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Ovarian cancer: Novel mechanisms and therapeutic targets regarding the microenvironment in the abdominal cavity. International journal Open Access

Masato Yoshihara, Shohei Iyoshi, Kazumasa Mogi, Kaname Uno, Hiroki Fujimoto, Emiri Miyamoto, Satoshi Nomura, Kazuhisa Kitami, Hiroaki Kajiyama

The journal of obstetrics and gynaecology research Vol. 49 ( 11 ) page： 2620 - 2628 2023.11

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Ovarian cancer is an intractable disease that is mostly diagnosed at an advanced stage and has a high recurrence rate. The early development of characteristic peritoneal dissemination via ascites contributes to a poor prognosis. Based on the "seed and soil" theory, ovarian cancer is considered to form a disseminated tumor that interacts with the peritoneum; superficial mesothelial cells are structurally important. Thus far, we have reported that peritoneal mesothelial cells, which originally are ecological defenses, transform into ovarian cancer-associated mesothelial cells, which are allies of cancer. They are found to be actively involved in the formation of a friendly "soil" that promotes the survival of "seeds" of ovarian cancer cells. We also demonstrated that the progression of ovarian cancer and the induction of its refractory nature are partially mediated through competition and cooperation between ovarian cancer and mesothelial cells. We believe that it is necessary to shift the aim of treatment strategies from solely targeting cancer cells to focusing on the crosstalk between the surrounding environment and ovarian cancer, an approach that ultimately aims to achieve "coexistence" with cancer through disease control.

DOI： 10.1111/jog.15756

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The prognostic impact of limited-staging surgery in patients with stage ia epithelial ovarian cancer: a multi-center study with a propensity score-adjusted analysis Open Access

Miyamoto, E; Suzuki, H; Yoshihara, M; Iyoshi, S; Mogi, K; Uno, K; Fujimoto, H; Kitami, K; Tano, S; Kajiyama, H

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 33 ( SUPPL_4 ) page： A196 - A196 2023.11

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DOI： 10.1136/ijgc-2023-IGCS.355

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増大特集代謝 Ⅲ.代謝とがん肥満と卵巣がん

伊吉祥平, 吉原雅人, 梶山広明

生体の科学 Vol. 74 ( 5 ) page： 458 - 459 2023.10

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Publisher：株式会社医学書院

DOI： 10.11477/mf.2425201752

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The sarcopenia index measured using the lumbar paraspinal muscle is associated with prognosis in endometrial cancer. International journal

Kaname Uno, Nobuhisa Yoshikawa, Kazuhisa Kitami, Sho Mori, Takahiro Shibata, Shohei Iyoshi, Hiroki Fujimoto, Kazumasa Mogi, Masato Yoshihara, Satoshi Tamauchi, Yoshiki Ikeda, Akira Yokoi, Kazuyoshi Kato, Tsutomu Hoshiba, Hidenori Oguchi, Hiroaki Kajiyama

Japanese journal of clinical oncology Vol. 53 ( 10 ) page： 942 - 949 2023.10

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OBJECTIVE: The number of type-II endometrial cancer patients has been increasing and the prognosis is not favorable. We aim to investigate whether sarcopenia index in any of several different muscles could serve as a novel biomarker of prognosis in patients with type-II endometrial cancer. METHODS: We retrospectively investigated a total of 194 patients at four hospitals. Ninety patients were treated as derivation set and the other 104 patients as validation set. Using preoperative computed tomography images, we measured the horizontal cross-sectional area at the third lumbar spine level: the (i) psoas major, (ii) iliac and (iii) paraspinal muscle. The clinical information including recurrence-free survival and overall survival were retrospectively collected. These results were validated with external data sets of three hospitals. RESULTS: The median values of the sarcopenia index (cm2/m2) ± standard deviation with the first data of 90 patients using the psoas, iliac and paraspinal muscle were 3.4 ± 1.0, 1.7 ± 0.6 and 12.6 ± 3.2, respectively. In univariate analyses, the sarcopenia indexes measured using the psoas or paraspinal muscle were associated with recurrence-free survival and overall survival. On the other hand, in multivariate analyses, only the sarcopenia index using paraspinal muscle was significantly related to recurrence-free survival (hazard ratio = 3.78, 95% confidence intervals = 1.29-5.97, P = 0.009) and overall survival (hazard ratio = 3.13, 95% confidence interval = 1.18-8.26, P = 0.022). Paraspinal sarcopenia index was also related to overall survival (hazard ratio = 3.74, 95% confidence interval = 1.31-10.72, P = 0.014) even in patients with advanced stage. Serum albumin was significantly correlated with the sarcopenia index (P = 0.012). Within the analysis of the validation set, sarcopenia index using paraspinal muscle was related to recurrence-free survival (hazard ratio = 2.06, P = 0.045) in multivariate analysis and recurrence-free survival (P = 0.009) in patients with advanced stage. CONCLUSIONS: The sarcopenia index using the paraspinal muscle, not psoas, could be a suitable index to predict recurrence-free survival and overall survival in patients with type-II endometrial cancer even in advanced stage.

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完全腫瘍切除された上皮性卵巣がん患者での組織型毎の予後検討

茂木一将, 吉原雅人, 江本遼, 宮本絵美里, 藤本裕基, 宇野枢, 伊吉祥平, 玉内学志, 清水裕介, 横井暁, 池田芳樹, 芳川修久, 新美薫, 松井茂之, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 61回 page： O68 - 5 2023.10

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The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset. International journal Open Access

Masato Yoshihara, Shigehiko Mizutani, Kunio Matsumoto, Yukio Kato, Yusuke Masuo, Arita Harumasa, Shohei Iyoshi, Sho Tano, Hidesuke Mizutani, Tomomi Kotani, Eita Mizutani, Kiyosumi Shibata, Hiroaki Kajiyama

European journal of obstetrics & gynecology and reproductive biology: X Vol. 19 page： 100210 - 100210 2023.9

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A fetal pituitary hormone, oxytocin which causes uterine contractions, increases throughout gestation, and its increase reaches 10-fold from week 32 afterward. Oxytocin is, on the other hand, degraded by placental leucine aminopeptidase (P-LAP) which exists in both terminal villi and maternal blood. Maternal blood P-LAP increases with advancing gestation under the control of non-genomic effects of progesterone, which is also produced from the placenta. Progesterone is converted to estrogen by CYP17A1 localized in the fetal adrenal gland and placenta at term. The higher oxytocin concentrations in the fetus than in the mother demonstrate not only fetal oxytocin production but also its degradation and/or inhibition of leakage from fetus to mother by P-LAP. Until labor onset, the pregnant uterus is quiescent possibly due to the balance between increasing fetal oxytocin and P-LAP under control of progesterone. A close correlation exists between the feto-placental and maternal units in the placental circulation, although the blood in the two circulations does not necessarily mix. Fetal maturation results in progesterone withdrawal via the CYP17A1 activation accompanied with fetal oxytocin increase. Contribution of fetal oxytocin to labor onset has been acknowledged through the recognition that the effect of fetal oxytocin in the maternal blood is strictly regulated by its degradation by P-LAP under the control of non-genomic effects of progesterone. In all senses, the fetus necessarily takes the initiative in labor onset.

DOI： 10.1016/j.eurox.2023.100210

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The prognostic impact of limited-staging surgery in patients with stage IA epithelial ovarian cancer: a multi-center study with a propensity score-adjusted analysis. International journal

Emiri Miyamoto, Hironori Suzuki, Masato Yoshihara, Kazumasa Mogi, Shohei Iyoshi, Kaname Uno, Hiroki Fujimoto, Kazuhisa Kitami, Sho Tano, Ryo Emoto, Shigeyuki Matsui, Hiroaki Kajiyama

Japanese journal of clinical oncology Vol. 53 ( 8 ) page： 698 - 703 2023.7

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OBJECTIVE: Complete-staging surgery is recommended for stage IA ovarian cancer, but may be omitted for various reasons, including the preservation of fertility and an advanced age. We herein investigated the prognostic impact of limited-staging surgery in patients with stage IA epithelial ovarian cancer. METHODS: We retrospectively collected data on 4730 patients with malignant ovarian tumors from the databases of multiple institutions and ultimately included 293 with stage IA epithelial ovarian cancer. Limited-staging surgery was defined as one that did not involve hysterectomy, systematic retroperitoneal lymphadenectomy or the collection of ascites cytology. We used an inverse probability of treatment weighting analysis with propensity scores and estimated the hazard ratios of recurrence and death with limited-staging surgery. RESULTS: In total, 176 out of 293 patients (39.9%) were assigned to the limited-staging surgery group. After propensity score adjustments, no significant differences were observed in recurrence-free survival or overall survival between the limited- and complete-staging surgery groups. Even in the subgroup analysis with age stratification, recurrence-free survival and overall survival were similar in the limited- and complete-staging surgery groups. CONCLUSIONS: The present results indicate the limited prognostic impact of limited-staging surgery for stage IA epithelial ovarian cancer.

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CD271 contributes to progression of ovarian cancer via promoting cell migration and invasion

Miyamoto, E; Koya, Y; Yoshihara, M; Sugiyama, M; Iyoshi, S; Kitami, K; Uno, K; Mogi, K; Fujimoto, H; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 114 page： 364 - 364 2023.2

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Establishing the novel experimental model of tumor-associated fibrosis for ovarian cancer's metastasis

Fujimoto, H; Yoshihara, M; Yamakita, Y; Sugiyama, M; Koya, Y; Miyamoto, E; Mogi, K; Uno, K; Iyoshi, S; Kitami, K; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 114 page： 1223 - 1223 2023.2

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Impact of obesity and the role of dedifferentiated adipocytes upon peritoneal metastasis of ovarian cancer

Iyoshi, S; Yoshihara, M; Nakamura, K; Sumi, A; Sugiyama, M; Koya, Y; Miyamoto, E; Fujimoto, H; Mogi, K; Uno, K; Kitami, K; Emoto, R; Matsui, S; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 114 page： 978 - 978 2023.2

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Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of TGF-β1/THBS1

Kitami, K; Yoshihara, M; Yamakita, Y; Sugiyama, M; Koya, Y; Miyamoto, E; Fujimoto, H; Iyoshi, S; Uno, K; Mogi, K; Kato, K; Nawa, A; Enomoto, A; Kajiyama, H

CANCER SCIENCE Vol. 114 page： 1047 - 1047 2023.2

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Notch signaling can be a new therapeutic target for advanced ovarian cancer

Sugiyama, M; Yoshihara, M; Koya, Y; Kitami, K; Uno, K; Iyoshi, S; Mogi, K; Yokoi, A; Nakamura, K; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 114 page： 2065 - 2065 2023.2

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Mesothelial cells that phagocytosed ovarian cancer cells have enhanced signals that suppress antitumor immunity

Koya, Y; Kitami, K; Yoshihara, M; Sugiyama, M; Mogi, K; Uno, K; Iyoshi, S; Fujimoto, H; Miyamoto, E; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 114 page： 1224 - 1224 2023.2

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Lineage tracing and functional analysis of ovarian cancer-associated mesothelial cells

Mogi, K; Yoshihara, M; Taniguchi, T; Yamakita, Y; Miyamoto, E; Fujimoto, H; Kitami, K; Iyoshi, S; Uno, K; Sugiyama, M; Koya, Y; Tomita, H; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 114 page： 1222 - 1222 2023.2

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卵巣癌の新規治療標的としての腫瘍関連線維症腹膜播種を十分に抑制するために(Tumor-associated fibrosis as a novel therapeutic target for ovarian cancer: Toward adequate control of peritoneal dissemination)

Fujimoto Hiroki, Yoshihara Masato, Sugiyama Mai, Yamakita Yoshihiko, Miyamoto Emiri, Uno Kaname, Iyoshi Shohei, Mogi Kazumasa, Kitami Kazuhisa, Koya Yoshihiro, Kajiyama Hiroaki, Nawa Akihiro

日本産科婦人科学会雑誌 Vol. 75 ( 臨増 ) page： S - 195 2023.2

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卵巣癌における悪性腹水の大規模プロテオームプロファイリングにより明らかとなった明確なプロテオームサブグループと予後バイオマーカー候補(Large scale proteome profiling of malignant ascites in ovarian cancer reveals distinct proteomic subgroups and prognostic biomarker candidates)

Iyoshi Shohei, Dreyer Tobias, Yoshihara Masato, Yamakita Yoshihiko, Koya Yoshihiro, Sugiyama Mai, Nawa Akihiro, Magdolen Viktor, Schilling Oliver, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 75 ( 臨増 ) page： S - 190 2023.2

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メフリン陽性癌関連線維芽細胞は腹膜播種抑制の制御により進行卵巣癌に対して抗腫瘍効果を示す(Meflin-positive cancer-associated fibroblasts exhibit anti-tumor effect in advanced ovarian cancer through regulation of inhibition of peritoneal dissemination)

Miyamoto Emiri, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Fujimoto Hiroki, Iyoshi Shohei, Mogi Kazumasa, Uno Kaname, Tano Sho, Kitami Kazuhisa, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 75 ( 臨増 ) page： S - 205 2023.2

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シングルセル解析により明らかとなった腹膜播種における癌関連中皮細胞の多様性(Single-cell analysis reveals the diversity of cancer-associated mesothelial cells in the peritoneal dissemination)

Mogi Kazumasa, Yoshihara Masato, Miyamoto Emiri, Fujimoto Hiroki, Uno Kaname, Iyoshi Shohei, Kitami Kazuhisa, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 75 ( 臨増 ) page： S - 238 2023.2

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Follicle development and its prediction in patients with primary ovarian insufficiency: Possible treatments and markers to maximize the ability to conceive with residual follicles. Open Access

Satoko Osuka, Yukiyo Kasahara, Shohei Iyoshi, Reina Sonehara, Natsuki Myake, Ayako Muraoka, Tomoko Nakamura, Akira Iwase, Hiroaki Kajiyama

Reproductive medicine and biology Vol. 22 ( 1 ) page： e12556 2023.1

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BACKGROUND: Primary ovarian insufficiency (POI) is characterized by the development of hypergonadotropic hypogonadism before 40 years of age and leads to intractable infertility. Although in vitro fertilization and embryo transfer with donated eggs enables pregnancy, not a few patients desire pregnancy using their oocytes. However, follicular development is rare and unpredictable in patients with POI. Thus, there is a need for treatments that promote the development of residual follicles and methods to accurately predict infrequent ovulation. METHODS: This review discusses the effects of various treatments for obtaining eggs from POI patients. Furthermore, this study focused a potential marker for predicting follicular growth in patients with POI. MAIN FINDINGS: Different treatments such as hormone-replacement therapy, dehydroepiandrosterone supplementation, platelet-rich plasma injection, and in vitro activation have shown varying degrees of effectiveness in retrieving oocytes from patients with POI. To predict follicle development in the cycle, elevated serum estradiol and reduced follicle-stimulating hormone (FSH) levels are important. However, these markers are not always reliable under continuous estradiol-replacement therapy. As a novel marker for predicting follicle growth, serum anti-Müllerian hormone (AMH) levels, measured using the picoAMH enzyme-linked immunosorbent assay, were found to predict follicle growth in patients and the cycle. CONCLUSION: This review highlights the challenges and available interventions for achieving pregnancy using a patient's oocytes in cases of POI. We believe that a combination of currently available treatments and prediction methods is the best strategy to enable patients with POI to conceive using their own eggs. Although AMH levels may predict follicle growth, further research is necessary to improve the chances of successful follicular development and conception in patients with POI.

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フィロポディアは卵巣癌細胞の中皮細胞層を介した移動に重要な役割を果たす(Filopodia Play an Important Role in the Trans-mesothelial Migration of Ovarian Cancer Cells)

Yamakita Yoshihiko, Yoshihara Masato, Koya Yoshihiro, Sugiyama Mai, Mogi Kazumasa, Uno Kaname, Kitami Kazuhisa, Iyoshi Shohei, Fujimoto Hiroki, Yamashita Mamoru, Nawa Akihiro, Kajiyama Hiroaki

The Journal of Obstetrics and Gynaecology Research Vol. 49 ( 1 ) page： 408 - 409 2023.1

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腹水中の転移小体は進行卵巣癌の腹膜播種進展と治療抵抗性を媒介する(Metastatic unit in ascites mediates progression of peritoneal dissemination and therapeutic resistance of advanced ovarian cancer)

Yoshihara Masato, Uno Kaname, Kitami Kazuhisa, Mogi Kazumasa, Iyoshi Shohei, Fujimoto Hiroki, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Nawa Akihiro, Kajiyama Hiroaki

The Journal of Obstetrics and Gynaecology Research Vol. 49 ( 1 ) page： 383 - 383 2023.1

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卵巣癌スフェロイドは癌細胞だけで構成されているか? 多光子顕微鏡による詳細な観察結果(Are ovarian cancer spheroids composed of only cancer cells?: the detailed observational findings with multi-photon microscopy)

Uno Kaname, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Fujimoto Hiroki, Mogi Kazumasa, Kitami Kazuhisa, Iyoshi Shohei, Yamakita Yoshihiko, Nawa Akihiro, Kajiyama Hiroaki

The Journal of Obstetrics and Gynaecology Research Vol. 49 ( 1 ) page： 382 - 382 2023.1

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腹膜微小環境は卵巣癌の播種をどのように促進するか? コンディショナルノックインマウスを用いた中皮細胞の系譜追跡(How peritoneal microenvironment promotes ovarian cancer dissemination?: A mesothelial cell lineage tracing using conditional knock-in mouse)

Mogi Kazumasa, Yoshihara Masato, Uno Kaname, Kitami Kazuhisa, Iyoshi Shohei, Fujimoto Hiroki, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Nawa Akihiro, Kajiyama Hiroaki

The Journal of Obstetrics and Gynaecology Research Vol. 49 ( 1 ) page： 382 - 382 2023.1

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腹膜播種における腹膜中皮細胞による卵巣癌細胞貪食の新規メカニズムと免疫抑制作用の可能性腹膜中皮細胞は敵か味方か(A novel mechanism of ovarian cancer cell phagocytosis by mesothelium and possible immunosuppressive effect in peritoneal dissemination: Are mesothelial cells foe or friend?)

Kitami Kazuhisa, Koya Yoshihiro, Yoshihara Masato, Uno Kaname, Mogi Kazumasa, Iyoshi Shohei, Fujimoto Hiroki, Sugiyama Mai, Yamakita Yoshihiko, Nawa Akihiro, Kajiyama Hiroaki

The Journal of Obstetrics and Gynaecology Research Vol. 49 ( 1 ) page： 373 - 373 2023.1

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Who are the long-term survivors of recurrent ovarian carcinoma?: a retrospective analysis of a multicenter study.

Masato Yoshihara, Kazumasa Mogi, Kazuhisa Kitami, Kaname Uno, Shohei Iyoshi, Sho Tano, Hiroki Fujimoto, Emiri Miyamoto, Nobuhisa Yoshikawa, Ryo Emoto, Shigeyuki Matsui, Hiroaki Kajiyama

International journal of clinical oncology Vol. 27 ( 10 ) page： 1660 - 1668 2022.10

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BACKGROUND: The aim of the present study was to investigate the incidence and hallmarks of long-term survivors of recurrent ovarian carcinoma (LTSROC) in a large-scale retrospective cohort of patients from a multicenter study group. METHODS: We performed a regional multicenter retrospective study between January 1986 and September 2021 using clinical data collected under the central pathological review system. Patients who underwent surgery for primary OC at diagnosis and developed recurrent tumors after the initial treatment were included. We defined LTSROC as patients who survived for 5 years or longer after initial tumor recurrence and examined factors affecting the long-term survival of ROC and outcomes of LTSROC. RESULTS: We collected information on patients with malignant ovarian tumors and finally 657 of them that developed ROC were included in the study population. Sixty-eight (10.4%) patients were LTSROC while 399 (60.7%) were short-term survivors of recurrent ovarian carcinoma. In a multivariate logistic regression analysis, negative ascites cytology [odds ratio (OR) 1.865; 95% CI 1.026-3.393; p = 0.041] and a recurrence-free interval (RFI) of 1 year or longer (OR 2.896; 95% CI 1.546-5.425; p < 0.001) were identified as independent factors associated with LTSROC. Approximately 80% of LTSROC presented with solitary recurrent tumors. Furthermore, more than 50% of LTSROC underwent tumor debulking surgery for the first recurrent tumor with or without chemotherapy. CONCLUSION: RFI of 1 year or longer and negative ascites cytology in the initial surgery were identified as independent predictive factors for LTSROC.

DOI： 10.1007/s10147-022-02214-9

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Obesity contributes to the stealth peritoneal dissemination of ovarian cancer: a multi-institutional retrospective cohort study. International journal

Shohei Iyoshi, Asami Sumi, Masato Yoshihara, Kazuhisa Kitami, Kazumasa Mogi, Kaname Uno, Hiroki Fujimoto, Emiri Miyamoto, Sho Tano, Nobuhisa Yoshikawa, Ryo Emoto, Shigeyuki Matsui, Hiroaki Kajiyama

Obesity (Silver Spring, Md.) Vol. 30 ( 8 ) page： 1599 - 1607 2022.8

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OBJECTIVE: The clinical significance of a higher BMI on the prognosis of ovarian cancer remains controversial; therefore, a more detailed analysis is demanded. This study investigated the impact of BMI on peritoneum-specific recurrence to clarify the involvement of adipose tissue in the proliferation of cancer cells at sites of peritoneal dissemination. METHODS: Among 4,730 patients with malignant ovarian tumors, 280 diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IIB to IIIC epithelial ovarian cancer and who underwent complete resection in the primary surgery were included in the present study. RESULTS: There were 42, 201, and 37 women in the low, normal, and high BMI groups, respectively. Peritoneum-specific recurrence-free survival and overall survival were both significantly shorter in patients with a high BMI than in those with a normal BMI (p = 0.028 and 0.018, respectively). No significant differences were observed in the distribution of sites of recurrence between these two groups. A multivariate analysis identified obesity as an independent prognostic factor in addition to pT3 tumor staging and positive ascites cytology. CONCLUSIONS: Patients with a high BMI had a significantly worse prognosis than those with a normal BMI, and peritoneal adipose tissue may have contributed to this difference.

DOI： 10.1002/oby.23497

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Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis. International journal Open Access

Kazuhisa Kitami, Masato Yoshihara, Satoshi Tamauchi, Mai Sugiyama, Yoshihiro Koya, Yoshihiko Yamakita, Hiroki Fujimoto, Shohei Iyoshi, Kaname Uno, Kazumasa Mogi, Yoshiki Ikeda, Akira Yokoi, Nobuhisa Yoshikawa, Kimihiro Nishino, Kaoru Niimi, Akihiro Nawa, Atsushi Enomoto, Hiroaki Kajiyama

Matrix biology : journal of the International Society for Matrix Biology Vol. 109 page： 70 - 90 2022.5

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Ovarian cancer (OvCa), a lethal gynecological malignancy, disseminates to the peritoneum. Mesothelial cells (MCs) act as barriers in the abdominal cavity, preventing the adhesion of cancer cells. However, in patients with OvCa, they are transformed into cancer-associated mesothelial cells (CAMs) via mesenchymal transition and form a favorable microenvironment for tumors to promote metastasis. However, attempts for restoring CAMs to their original state have been limited. Here, we investigated whether inhibition of mesenchymal transition and restoration of MCs by vitamin D suppressed the OvCa dissemination in vitro and in vivo. The effect of vitamin D on the mutual association of MCs and OvCa cells was evaluated using in vitro coculture models and in vivo using a xenograft model. Vitamin D restored the CAMs, and thrombospondin-1 (component of the extracellular matrix that is clinically associated with poor prognosis and is highly expressed in peritoneally metastasized OvCa) was found to promote OvCa cell adhesion and proliferation. Mechanistically, TGF-β1 secreted from OvCa cells enhanced thrombospondin-1 expression in CAMs via Smad-dependent TGF-β signaling. Vitamin D inhibited mesenchymal transition in MCs and suppressed thrombospondin-1 expression via vitamin D receptor/Smad3 competition, contributing to the marked reduction in peritoneal dissemination in vivo. Importantly, vitamin D restored CAMs from a stabilized mesenchymal state to the epithelial state and normalized thrombospondin-1 expression in preclinical models that mimic cancerous peritonitis in vivo. MCs are key players in OvCa dissemination and peritoneal restoration and normalization of thrombospondin-1 expression by vitamin D may be a novel strategy for preventing OvCa dissemination.

DOI： 10.1016/j.matbio.2022.03.003

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Metastatic Voyage of Ovarian Cancer Cells in Ascites with the Assistance of Various Cellular Components. International journal Open Access

Kaname Uno, Shohei Iyoshi, Masato Yoshihara, Kazuhisa Kitami, Kazumasa Mogi, Hiroki Fujimoto, Mai Sugiyama, Yoshihiro Koya, Yoshihiko Yamakita, Akihiro Nawa, Tomohiro Kanayama, Hiroyuki Tomita, Atsushi Enomoto, Hiroaki Kajiyama

International journal of molecular sciences Vol. 23 ( 8 ) 2022.4

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Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and has a unique metastatic route using ascites, known as the transcoelomic root. However, studies on ascites and contained cellular components have not yet been sufficiently clarified. In this review, we focus on the significance of accumulating ascites, contained EOC cells in the form of spheroids, and interaction with non-malignant host cells. To become resistant against anoikis, EOC cells form spheroids in ascites, where epithelial-to-mesenchymal transition stimulated by transforming growth factor-β can be a key pathway. As spheroids form, EOC cells are also gaining the ability to attach and invade the peritoneum to induce intraperitoneal metastasis, as well as resistance to conventional chemotherapy. Recently, accumulating evidence suggests that EOC spheroids in ascites are composed of not only cancer cells, but also non-malignant cells existing with higher abundance than EOC cells in ascites, including macrophages, mesothelial cells, and lymphocytes. Moreover, hetero-cellular spheroids are demonstrated to form more aggregated spheroids and have higher adhesion ability for the mesothelial layer. To improve the poor prognosis, we need to elucidate the mechanisms of spheroid formation and interactions with non-malignant cells in ascites that are a unique tumor microenvironment for EOC.

DOI： 10.3390/ijms23084383

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Significance of platinum distribution to predict platinum resistance in ovarian cancer after platinum treatment in neoadjuvant chemotherapy. International journal Open Access

Kaname Uno, Nobuhisa Yoshikawa, Akira Tazaki, Shoko Ohnuma, Kazuhisa Kitami, Shohei Iyoshi, Kazumasa Mogi, Masato Yoshihara, Yoshihiro Koya, Mai Sugiyama, Satoshi Tamauchi, Yoshiki Ikeda, Akira Yokoi, Fumitaka Kikkawa, Masashi Kato, Hiroaki Kajiyama

Scientific reports Vol. 12 ( 1 ) page： 4513 - 4513 2022.3

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Most patients with ovarian cancer experience recurrence and develop resistance to platinum-based agents. The diagnosis of platinum resistance based on the platinum-free interval is not always accurate and timely in clinical settings. Herein, we used laser ablation inductively coupled plasma mass spectrometry to visualize the platinum distribution in the ovarian cancer tissues at the time of interval debulking surgery after neoadjuvant chemotherapy in 27patients with advanced high-grade serous ovarian cancer. Two distinct patterns of platinum distribution were observed. Type A (n = 16): platinum accumulation at the adjacent stroma but little in the tumor; type B (n = 11): even distribution of platinum throughout the tumor and adjacent stroma. The type A patients treated post-surgery with platinum-based adjuvant chemotherapy showed significantly shorter periods of recurrence after the last platinum-based chemotherapy session (p = 0.020) and were diagnosed with "platinum-resistant recurrence". Moreover, type A was significantly correlated with worse prognosis (p = 0.031). Post-surgery treatment with non-platinum-based chemotherapy could be effective for the patients classified as type A. Our findings indicate that the platinum resistance can be predicted prior to recurrence, based on the platinum distribution; this could contribute to the selection of more appropriate adjuvant chemotherapy, which may lead to improves prognoses.

DOI： 10.1038/s41598-022-08503-7

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Adipose-mesothelial crosstalk regulates peritoneal tumor microenvironment and accelerates metastasis of ovarian cancer

Mogi, K; Yoshihara, M; Uno, K; Iyoshi, S; Kitami, K; Sugiyama, M; Koya, Y; Tamauchi, S; Yokoi, A; Yoshikawa, N; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 113 page： 735 - 735 2022.2

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NGFR contributes the malignancy of ovarian carcinoma cells

Koya, Y; Sugiyama, M; Yoshihara, M; Kitami, K; Uno, K; Mogi, K; Iyoshi, S; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 113 page： 1033 - 1033 2022.2

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Vitamin D inhibits mesothelial-mesenchymal-transition accelerating peritoneal dissemination in ovarian cancer via THBS1

Kitami, K; Yoshihara, M; Sugiyama, M; Koya, Y; Yamakita, Y; Iyoshi, S; Uno, K; Mogi, K; Tamauchi, S; Yokoi, A; Yoshikawa, N; Nishino, K; Niimi, K; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 113 page： 729 - 729 2022.2

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Notch-dependent intra-tumoral heterogeneity mediates cell-fate dynamics and development of peritoneal dissemination

Yoshihara, M; Sugiyama, M; Koya, Y; Iyoshi, S; Kitami, K; Uno, K; Mogi, K; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 113 page： 1405 - 1405 2022.2

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Notch signaling contributes to drug resistance acquisition through metabolic alteration in advanced ovarian cancer

Sugiyama, M; Yoshihara, M; Koya, Y; Kitami, K; Uno, K; Iyoshi, S; Mogi, K; Yokoi, A; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 113 page： 1280 - 1280 2022.2

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中皮による卵巣癌細胞の貪食の新規メカニズムと腹膜播種における免疫抑制作用の可能性中皮細胞は敵か味方か(A novel mechanism of ovarian cancer cell phagocytosis by mesothelium and possible immunosuppressive effect in peritoneal dissemination: Are mesothelial cells foe or friend?)

Kitami Kazuhisa, Koya Yoshihiro, Yoshihara Masato, Uno Kaname, Mogi Kazumasa, Iyoshi Shohei, Fujimoto Hiroki, Sugiyama Mai, Yamakita Yoshihiko, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 74 ( 臨増 ) page： S - 179 2022.2

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腹水中の転移性ユニットによる進行卵巣癌の腹膜播種と治療抵抗性の仲介(Metastatic unit in ascites mediates progression of peritoneal dissemination and therapeutic resistance of advanced ovarian cancer)

Yoshihara Masato, Uno Kaname, Kitami Kazuhisa, Mogi Kazumasa, Iyoshi Shohei, Fujimoto Hiroki, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 74 ( 臨増 ) page： S - 189 2022.2

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卵巣癌細胞の腹膜中皮を介した遊走に重要な役割を果たすFilopodia(Filopodia Play an Important Role in the Trans-mesothelial Migration of Ovarian Cancer Cells)

Yamakita Yoshihiko, Yoshihara Masato, Koya Yoshihiro, Sugiyama Mai, Mogi Kazumasa, Uno Kaname, Kitami Kazuhisa, Iyoshi Shohei, Fujimoto Hiroki, Yamashita Mamoru, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 74 ( 臨増 ) page： S - 215 2022.2

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卵巣癌スフェロイドは癌細胞のみから構成されているのか多光子顕微鏡による詳細な観察結果(Are ovarian cancer spheroids composed of only cancer cells?: the detailed observational findings with multi-photon microscopy)

Uno Kaname, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Fujimoto Hiroki, Mogi Kazumasa, Kitami Kazuhisa, Iyoshi Shohei, Yamakita Yoshihiko, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 74 ( 臨増 ) page： S - 188 2022.2

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腹膜微小環境はどのように卵巣癌の播種を促進するか条件付きノックインマウスを用いた中皮細胞系統の追跡(How peritoneal microenvironment promotes ovarian cancer dissemination?: A mesothelial cell lineage tracing using conditional knock-in mouse)

Mogi Kazumasa, Yoshihara Masato, Uno Kaname, Kitami Kazuhisa, Iyoshi Shohei, Fujimoto Hiroki, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 74 ( 臨増 ) page： S - 188 2022.2

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Differential-diagnostic and therapeutic challenges in the management of ruptured corpus luteum cyst with undiagnosed intrauterine pregnancy in the early first trimester and ruptured ovarian pregnancy Open Access

Akihiro Takeda, Shiori Tsuge, Shohei Iyoshi

Clinical and Experimental Obstetrics and Gynecology Vol. 49 ( 1 ) 2022.1

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Background: The similarities in clinical features between ruptured corpus luteum cyst (RCLC) with undiagnosed intrauterine pregnancy in the early first trimester (RCLC-P) and ruptured ovarian pregnancy are well established. However, the identification of differences between these two morbid conditions is important to determine the causes and manage the hemoperitoneum without devastation of pregnancy in RCLC-P. Furthermore, the pregnancy outcomes after laparoscopic surgery in women with RCLC-P are not recognized. Methods: Retrospective observational study of six women with RCLC-P and seven women with ruptured ovarian pregnancy. Results: All cases were referred under strong suspicion of ruptured ectopic pregnancy due to lower abdominal pain and positive urinary pregnancy test after spontaneous conception. The estimated median number of gestational weeks in RCLC-P (5 weeks) was significantly lower than that for ruptured ovarian pregnancy (7 weeks). At triage, the median serum levels of beta-human chorionic gonadotropin (β -hCG) were significantly lower in RCLC-P (592 IU/L) than ruptured ovarian pregnancy (3723 IU/L) (p = 0.01). In all six cases with RCLC-P, laparoscopic ovary-sparing surgery was performed. Among the four women who received postoperative supplementation of progesterone, uneventful vaginal delivery occurred at term in three cases. Conclusions: Early gestational age and lower serum β -hCG levels at triage, as well as non-declining levels of serum β -hCG on the day after surgery, were significant predictors of RCLC-P rather than ruptured ovarian pregnancy. Laparoscopic surgery was a feasible option for the management of RCLC-P with appropriate postoperative luteal support to achieve successful obstetric outcomes.

DOI： 10.31083/j.ceog4901019

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Uterine artery chemoembolization for management of unruptured interstitial pregnancy diagnosed in the early first trimester Open Access

Akihiro Takeda, Shohei Iyoshi, Satoshi Tamauchi, Wataru Koike

Clinical and Experimental Obstetrics and Gynecology Vol. 49 ( 1 ) 2022.1

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Background: With the increased frequency of diagnosis of interstitial pregnancy in the early first trimester, non-surgical management of unruptured interstitial pregnancy has become an important issue. However, management of unruptured interstitial pregnancy by uterine artery chemoembolization (UACE) with dactinomycin has never been evaluated via a case series. Methods: With this aim, a retrospective review of electronic chart records over a five-year period was performed, and a series of cases of unruptured interstitial pregnancy during the first trimester was extracted. Diagnostic procedures included ultrasonography, magnetic resonance imaging (MRI), and laparoscopic examination, if necessary. Conservative treatment regimen included UACE. Additional administration of methotrexate (MTX) was considered when an insufficient decline of serum β-hCG was noted. Clinical characteristics and treatment outcomes are described. Results: Among four women diagnosed with unruptured interstitial pregnancy at six weeks of gestation, one case was managed by laparoscopic cornuostomy due to concerns of rupture after the identification of thinning of the myometrium, whereas the other three cases were initially managed by UACE. One case of proximal interstitial pregnancy was diagnosed solely by MRI, whereas two cases of distal interstitial pregnancy was diagnosed by exploratory laparoscopy. Two cases were successfully managed by UACE alone, whereas one case required additional systemic administration of MTX to achieve resolution of gestational products after UACE. Thereafter, one patient conceived spontaneously and experienced a successful vaginal birth. Conclusions: This small case series emphasizes that UACE is a feasible minimally invasive option for the management of unruptured interstitial pregnancy identified in the early first trimester.

DOI： 10.31083/j.ceog4901011

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Pro-tumoral behavior of omental adipocyte-derived fibroblasts in tumor microenvironment at the metastatic site of ovarian cancer. International journal Open Access

Shohei Iyoshi, Masato Yoshihara, Kae Nakamura, Mai Sugiyama, Yoshihiro Koya, Kazuhisa Kitami, Kaname Uno, Kazumasa Mogi, Sho Tano, Hiroyuki Tomita, Keiji Kajiwara, Masayasu Taki, Shigehiro Yamaguchi, Akihiro Nawa, Hiroaki Kajiyama

International journal of cancer Vol. 149 ( 11 ) page： 1961 - 1972 2021.12

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Adipocyte-rich omentum offers "good soil" for disseminating ovarian cancer (OvCa), contributing to therapeutic difficulty. However, little is understood about the association between adipocytes and tumor growth at peritoneal dissemination site. Herein, we report the induction of adipocyte dedifferentiation by OvCa cells and pro-tumorigenic effects of resulted adipocyte-derived fibroblasts. We confirmed that malignant ascites promoted the dedifferentiation of the primary human adipocytes obtained from surgical omental specimen into omental adipocyte-derived fibroblast (O-ADF) that possess both mesenchymal stem cell and myofibroblast-like features. This promotion of dedifferentiation by malignant ascites was blocked by addition of Wnt signaling inhibitor. The effects of dedifferentiated adipocytes in proliferation and migration of OvCa cells were analyzed with in vitro coculturing experimental models and in vivo mice model, and we demonstrated that OvCa cell lines showed enhanced proliferative characteristics, as well as increased migratory abilities upon coculturing with O-ADF. Additionally, exogenous transforming growth factor-β1 augmented desmoplastic morphological change of O-ADF, leading to higher proliferative ability. Our results suggest that OvCa cells promote dedifferentiation of peritoneal adipocytes by activating Wnt/β-catenin signaling, and generated O-ADFs exhibit pro-tumoral hallmarks.

DOI： 10.1002/ijc.33770

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Long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery for epithelial ovarian cancer. International journal Open Access

Munehisa Shigeyama, Masato Yoshihara, Kazuhisa Kitami, Kazumasa Mogi, Kaname Uno, Shohei Iyoshi, Sho Tano, Nobuhisa Yoshikawa, Hiroaki Kajiyama

European journal of obstetrics, gynecology, and reproductive biology Vol. 267 page： 221 - 225 2021.12

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OBJECTIVE: The aim of this study was to investigate long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery (FSS) to verify the feasibility of the limited surgery for epithelial ovarian cancer (OvCa). STUDY DESIGN: We performed a regional multicenter retrospective study from January 1986 and March 2020, using clinical data corrected under the central pathological review system. Patients with recurrent tumor after surgery for stage I epithelial OvCa, aged equal or younger than 45 years were included for this study. We evaluated effect of FSS regarding long-term post-recurrence survival with statistical adjustment of propensity score-based method. RESULTS: With the Kaplan-Meier method, original and adjusted survival curves were estimated for recurrence-after survival of patients with (n = 14) and without FSS (n = 26). Median time to disease-specific death was 18.6 months. In both original and adjusted cohorts, there were no significant difference between the two groups (log rank test; P > 0.05). Hazard ratio of disease-specific death was 1.264 (95% confidence interval, 0.563-2.836; P = 0.570) in original and 1.354 (95% confidence interval, 0.702-2.611; P = 0.366) in adjusted population. This result indicated that patients with FSS was not associated with poorer prognosis for recurrence-after survival than those without. When comparing patients not receiving FSS, patients receiving FSS with recurrence at spared ovary followed not significantly different survival outcome as well as those with extra-ovarian recurrence. CONCLUSION: There was no significant difference of long-term post-recurrence survival outcomes between patients of epithelial OvCa with and without FSS in young women of reproductive age.

DOI： 10.1016/j.ejogrb.2021.11.015

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Impact of incomplete surgery and adjuvant chemotherapy for the intraoperative rupture of capsulated stage I epithelial ovarian cancer: a multi-institutional study with an in-depth subgroup analysis. International journal Open Access

Masato Yoshihara, Satoshi Tamauchi, Shohei Iyoshi, Kazuhisa Kitami, Kaname Uno, Kazumasa Mogi, Hiroaki Kajiyama

Journal of gynecologic oncology Vol. 32 ( 5 ) page： e66 2021.9

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OBJECTIVE: The aim of the present study was to examine the effects of incomplete surgery and adjuvant chemotherapy on the prognosis of patients with intraoperative rupture of capsulated stage I epithelial ovarian cancer (OvCa). METHODS: A regional retrospective study was conducted between 1986 and 2019. Among 4,730 patients with malignant ovarian tumors, 534 women with International Federation of Gynecology and Obstetrics stage IA and IC1 epithelial OvCa were eligible. Differences in survival outcomes were examined between patients with stage IA and IC1 tumors and the effects of uterine preservation, complete-staging lymphadenectomy, and adjuvant chemotherapy were investigated by an in-depth subgroup analysis. To analyze therapeutic effects, baseline imbalances were adjusted using propensity score (PS). RESULTS: The prognosis of patients with stage IC1 tumors was worse than those with stage IA. Surgical spill did not affect the site of recurrence. In the PS-adjusted subgroup analysis, uterine preservation (hazard ratio [HR]=1.669; 95% confidence interval [CI]=1.052-2.744), incomplete-staging lymphadenectomy (HR=1.689; 95% CI=1.211-2.355), and the omission of adjuvant chemotherapy (HR=3.729; 95% CI=2.090-6.653) significantly increased the HR of recurrence for patients with stage IC1 tumors compared to those with stage IA tumors. Adjuvant chemotherapy decreased the impact of rupture with uterine preservation (HR=0.159; 95% CI=0.230-1.168) or incomplete-staging lymphadenectomy (HR=0.987; 95% CI=0.638-1.527). CONCLUSION: The present results suggest intraoperative rupture of capsulated stage I epithelial OvCa is associated with a poor prognosis. When chemotherapy is given for patients receiving incomplete surgery, there is no longer an increased risk of recurrence observed with the rupture.

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中皮細胞を有する卵巣癌スフェロイドは中皮単層への接着能力が高く腹膜播種を促す新しい転移ユニットの合併(Ovarian cancer spheroid with mesothelial cells has higher ability to adhere mesothelial monolayer and promote peritoneal dissemination: Complication of a novel metastatic unit)

Uno Kaname, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Mogi Kazumasa, Iyoshi Shohei, Kitami Kazuhisa, Tamauchi Satoshi, Yoshikawa Nobuhisa, Yokoi Akira, Nawa Akihiro, Kajiyama Hiroaki

The Journal of Obstetrics and Gynaecology Research Vol. 47 ( 8 ) page： 2893 - 2893 2021.8

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脂肪-中皮細胞により制御される卵巣癌微小環境と腹膜播種(Adipose-mesothelial crosstalk regulates peritoneal tumor microenvironment and accelerates metastasis of ovarian cancer)

Mogi Kazumasa, Yoshihara Masato, Iyoshi Shohei, Tano Sho, Uno Kaname, Kitami Kazuhisa, Sugiyama Mai, Koya Yoshihiro, Nawa Akihiro, Kajiyama Hiroaki

The Journal of Obstetrics and Gynaecology Research Vol. 47 ( 8 ) page： 2822 - 2822 2021.8

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活性型ビタミンDによる卵巣癌腹膜播種を亢進する腹膜中皮間葉転換を抑制する(Active vitamin D inhibits mesothelial-mesenchymal-transition accelerating peritoneal dissemination in ovarian cancer)

Kitami Kazuhisa, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Iyoshi Shohei, Uno Kaname, Mogi Kazumasa, Tamauchi Satoshi, Yokoi Akira, Yoshikawa Nobuhisa, Nawa Akihiro, Kajiyama Hiroaki

The Journal of Obstetrics and Gynaecology Research Vol. 47 ( 8 ) page： 2822 - 2822 2021.8

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卵巣癌におけるadipo-peritoneal crosstalkを標的とした新規戦略卵巣脂肪細胞由来線維芽細胞の腫瘍促進作用と新たな治療標的としての脱分化抑制物質をスクリーニングする方法論(Novel strategy for targeting adipo-peritoneal crosstalk in ovarian cancer: A tumor promoting behaviors of omental adipocyte-derived fibroblasts and a methodology to screen anti-dedifferentiation substances as a new therapeutic target)

Iyoshi Shohei, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Kitami Kazuhisa, Uno Kaname, Mogi Kazumasa, Kajiyama Hiroaki

The Journal of Obstetrics and Gynaecology Research Vol. 47 ( 8 ) page： 2891 - 2891 2021.8

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腹膜誘導性のNotch依存性腫瘍内不均一性は細胞運命のダイナミクスと転移性卵巣癌の発生に寄与する(Peritoneum-inducible Notch dependent intra-tumoral heterogeneity mediates cell-fate dynamics and development of metastatic ovarian cancer)

Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Iyoshi Shohei, Kitami Kazuhisa, Uno Kaname, Mogi Kazumasa, Tano Sho, Nawa Akihiro, Kajiyama Hiroaki

The Journal of Obstetrics and Gynaecology Research Vol. 47 ( 8 ) page： 2802 - 2802 2021.8

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A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer. International journal Open Access

Masato Yoshihara, Ryo Emoto, Kazuhisa Kitami, Shohei Iyoshi, Kaname Uno, Kazumasa Mogi, Sho Tano, Nobuhisa Yoshikawa, Shigeyuki Matsui, Hiroaki Kajiyama

Scientific reports Vol. 11 ( 1 ) page： 15154 - 15154 2021.7

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Positive ascites cytology is a strong prognostic factor in patients with early-stage ovarian cancer (OvCa). However, limited information is currently available on the impact of positive ascites cytology on patient prognoses under each clinical background. We herein investigated the comprehensive impact of positive ascites cytology on patients with epithelial OvCa and the effectiveness of additional therapeutic interventions, including complete staging surgery and chemotherapy. Among 4730 patients with malignant ovarian neoplasms, retrospectively identified in multiple institutions, 1906 with epithelial OvCa were included. In the investigation of its effects on clinical factors using a multivariate analysis, positive ascites cytology correlated with a poor prognosis. Positive ascites cytology had a significantly worse prognosis than those with negative cytology in all subgroups except for patients with stage IV tumors and a mucinous histology. Chemotherapy may be effective in reducing the negative impact of positive ascites cytology on the prognosis of patients in terms of progression-free and overall survivals, while complete staging surgery did not improve the prognosis of patients with positive ascites cytology. Collectively, our findings suggested that positive ascites cytology had a negative impact on the prognosis of patients with epithelial OvCa, but not those with stage IV tumors or a mucinous histology.

DOI： 10.1038/s41598-021-93718-3

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Does complete-staging lymphadenectomy improve survival outcomes in stage I endometrioid epithelial ovarian carcinoma? A multi-institutional retrospective study with propensity score-weighted analysis. International journal Open Access

Masato Yoshihara, Satoshi Tamauchi, Shohei Iyoshi, Kazuhisa Kitami, Kaname Uno, Sho Tano, Shigeyuki Matsui, Hiroaki Kajiyama

Japanese journal of clinical oncology Vol. 51 ( 3 ) page： 387 - 392 2021.3

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BACKGROUND: We investigated the prognostic impact of complete-staging lymphadenectomy on patients with clinically apparent Stage I endometrioid epithelial ovarian carcinoma. METHODS: We conducted a regional multi-institutional retrospective study between 1986 and 2018. Amongst 4897 patients with malignant ovarian tumours diagnosed under central pathological review, 259 women with Stage I endometrioid epithelial ovarian carcinoma were eligible. We evaluated differences in survival of patients with both pelvic and para-aortic lymphadenectomy (Group A) and those with only pelvic lymphadenectomy and/or clinical lymph node evaluation (Group B). To analyse the therapeutic effects, the baseline imbalance between patients with both pelvic and para-aortic lymphadenectomy and others was adjusted with an inverse probability of treatment weighting using propensity score involving independent clinical variables. RESULTS: In total, 145 patients (56.0%) received both pelvic and para-aortic lymphadenectomy. With propensity score-based adjustment, estimated survival was better in Group A compared with that in Group B but not significant. Pelvic and para-aortic lymphadenectomy also led to no significant improvement of overall survival in most of the subgroups. However, point estimations of the hazard ratio for lymphadenectomy in patients with an age of 45 or younger (hazard ratio, 0.304; 95% confidence interval, 0.094-0.982), a Grade 1-2 (hazard ratio, 0.441; 95% confidence interval, 0.204-0.954) and T1c2-3 tumour (hazard ratio, 0.449; 95% confidence interval, 0.164-1.231) were better compared with those with the opposite characteristics. CONCLUSIONS: Complete-staging lymphadenectomy was not a significant prognostic factor in patients with Stage I endometrioid epithelial ovarian carcinoma, where we still need to explore appropriate candidate for the procedure.

DOI： 10.1093/jjco/hyaa206

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Ovarian Cancer-Associated Mesothelial Cells: Transdifferentiation to Minions of Cancer and Orchestrate Developing Peritoneal Dissemination. International journal Open Access

Kazumasa Mogi, Masato Yoshihara, Shohei Iyoshi, Kazuhisa Kitami, Kaname Uno, Sho Tano, Yoshihiro Koya, Mai Sugiyama, Yoshihiko Yamakita, Akihiro Nawa, Hiroyuki Tomita, Hiroaki Kajiyama

Cancers Vol. 13 ( 6 ) page： 1 - 13 2021.3

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Ovarian cancer has one of the poorest prognoses among carcinomas. Advanced ovarian cancer often develops ascites and peritoneal dissemination, which is one of the poor prognostic factors. From the perspective of the "seed and soil" hypothesis, the intra-abdominal environment is like the soil for the growth of ovarian cancer (OvCa) and mesothelial cells (MCs) line the top layer of this soil. In recent years, various functions of MCs have been reported, including supporting cancer in the OvCa microenvironment. We refer to OvCa-associated MCs (OCAMs) as MCs that are stimulated by OvCa and contribute to its progression. OCAMs promote OvCa cell adhesion to the peritoneum, invasion, and metastasis. Elucidation of these functions may lead to the identification of novel therapeutic targets that can delay OvCa progression, which is difficult to cure.

DOI： 10.3390/cancers13061352

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中皮細胞を有する卵巣癌スフェロイドは中皮単層への接着能力が高く腹膜播種を促す新しい転移ユニットの合併(Ovarian cancer spheroid with mesothelial cells has higher ability to adhere mesothelial monolayer and promote peritoneal dissemination: Complication of a novel metastatic unit)

Uno Kaname, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Mogi Kazumasa, Iyoshi Shohei, Kitami Kazuhisa, Tamauchi Satoshi, Yoshikawa Nobuhisa, Yokoi Akira, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 73 ( 臨増 ) page： S - 225 2021.3

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脂肪-中皮細胞により制御される卵巣癌微小環境と腹膜播種(Adipose-mesothelial crosstalk regulates peritoneal tumor microenvironment and accelerates metastasis of ovarian cancer)

Mogi Kazumasa, Yoshihara Masato, Iyoshi Shohei, Tano Sho, Uno Kaname, Kitami Kazuhisa, Sugiyama Mai, Koya Yoshihiro, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 73 ( 臨増 ) page： S - 154 2021.3

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活性型ビタミンDによる卵巣癌腹膜播種を亢進する腹膜中皮細胞のEMTを標的とした治療(Active vitamin D inhibits mesothelial-mesenchymal-transition accelerating peritoneal dissemination in ovarian cancer)

Kitami Kazuhisa, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Iyoshi Shohei, Uno Kaname, Mogi Kazumasa, Tamauchi Satoshi, Yokoi Akira, Yoshikawa Nobuhisa, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 73 ( 臨増 ) page： S - 154 2021.3

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卵巣癌におけるadipo-peritoneal crosstalkを標的とした新規戦略卵巣脂肪細胞由来線維芽細胞の腫瘍促進作用と新たな治療標的としての脱分化抑制物質をスクリーニングする方法論(Novel strategy for targeting adipo-peritoneal crosstalk in ovarian cancer; A tumor promoting behaviors of omental adipocyte-derived fibroblasts and a methodology to screen anti-dedifferentiation substances as a new therapeutic target)

Iyoshi Shohei, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Kitami Kazuhisa, Uno Kaname, Mogi Kazumasa, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 73 ( 臨増 ) page： S - 223 2021.3

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腹膜誘導性のNotch依存性腫瘍内不均一性は細胞運命のダイナミクスと転移性卵巣癌の発生に寄与する(Peritoneum-inducible Notch dependent intra-tumoral heterogeneity mediates cell-fate dynamics and development of metastatic ovarian cancer)

Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Iyoshi Shohei, Kitami Kazuhisa, Uno Kaname, Mogi Kazumasa, Tano Sho, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 73 ( 臨増 ) page： S - 134 2021.3

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Active vitamin D inhibits mesothelial-mesenchymal-transition accelerating peritoneal dissemination in ovarian cancer

Kitami, K; Yoshihara, M; Sugiyama, M; Koya, Y; Iyoshi, S; Uno, K; Mogi, K; Tamauchi, S; Yokoi, A; Yoshikawa, N; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 112 page： 351 - 351 2021.2

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How do peritoneal mesothelial cells on adipose tissue attract ovarian cancer cells?

Mogi, K; Yoshihara, M; Kitami, K; Iyoshi, S; Uno, K; Tano, S; Sugiyama, M; Koya, Y; Tamauchi, S; Yokoi, A; Yoshikawa, N; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 112 page： 341 - 341 2021.2

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Intra-tumoral polarity induced by Notch signaling can be a novel therapeutic target for advanced ovarian cancer

Yoshihara, M; Sugiyama, M; Koya, Y; Iyoshi, S; Kitami, K; Uno, K; Mogi, K; Tano, S; Tamauchi, S; Yokoi, A; Yoshikawa, N; Nawa, A; Kajiyama, H

CANCER SCIENCE Vol. 112 page： 363 - 363 2021.2

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Visualization of platinum resistance through mapping trace elements

Uno, K; Yoshikawa, N; Yoshihara, M; Tazaki, K; Kato, M; Kitami, K; Iyoshi, S; Tamauchi, S; Sugiyama, M; Koya, Y; Kajiyama, H

CANCER SCIENCE Vol. 112 page： 906 - 906 2021.2

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Microphthalmia-Associated Transcription Factor-Dependent Melanoma Cell Adhesion Molecule Activation Promotes Peritoneal Metastasis of Ovarian Cancer. International journal Open Access

Kazuhisa Kitami, Masato Yoshihara, Yoshihiro Koya, Mai Sugiyama, Shohei Iyoshi, Kaname Uno, Kazumasa Mogi, Sho Tano, Hiroki Fujimoto, Akihiro Nawa, Fumitaka Kikkawa, Hiroaki Kajiyama

International journal of molecular sciences Vol. 21 ( 24 ) page： 1 - 15 2020.12

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Ovarian cancer (OvCa) is one of the leading causes of death due to its high metastasis rate to the peritoneum. Recurrent peritoneal tumors also develop despite the use of conventional platinum-based chemotherapies. Therefore, it is still important to explore the factors associated with peritoneal metastasis, as these predict the prognosis of patients with OvCa. In this study, we investigated the function of microphthalmia-associated transcription factor (MITF), which contributes to the development of melanoma, in epithelial ovarian cancer (OvCa). High MITF expression was significantly associated with a poor prognosis in OvCa. Notably, MITF contributed to the motility and invasion of OvCa cells, and specifically with their peri-mesothelial migration. In addition, MITF-positive cells expressed the melanoma cell adhesion molecule (MCAM/CD146), which was initially identified as a marker of melanoma progression and metastasis, and MCAM expression was regulated by MITF. MCAM was also identified as a significant prognostic factor for poor progression-free survival in patients with OvCa. Collectively, our results suggest that MITF is a novel therapeutic target that potentially promotes peritoneal metastasis of OvCa.

DOI： 10.3390/ijms21249776

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Does uterine preservation affect survival outcomes of patients with stage I ovarian sex cord-stromal cell tumours? A multi-institutional study. International journal

Masato Yoshihara, Satoshi Tamauchi, Shohei Iyoshi, Kazuhisa Kitami, Kaname Uno, Nobuhisa Yoshikawa, Yoshiki Ikeda, Michiyasu Kawai, Tetsuro Nagasaka, Hiroaki Kajiyama

European journal of obstetrics, gynecology, and reproductive biology Vol. 254 page： 52 - 56 2020.11

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OBJECTIVE: Sex cord-stromal tumours of the ovary are relatively uncommon neoplasms that account for 3 % of all ovarian cancers. Uterine preservation with careful staging is achievable; however, conservative surgery remains controversial. This study examined the prognostic effects of uterine preservation in patients with stage I sex cord-stromal tumours. STUDY DESIGN: This retrospective cohort study was undertaken between January 1986 and February 2019, and the clinicopathological data of 4897 women with malignant ovarian tumours were collected. Seventy-seven patients with stage I sex cord-stromal tumours were eligible for inclusion. The characteristics and survival outcomes of these patients were examined. To investigate the prognostic effects of uterine-preserving surgery, baseline imbalances between patients with and without uterine-preserving surgery were adjusted using an inverse probability of treatment weighting with propensity scores composed of independent clinical variables. RESULTS: The mean ages of patients in the uterine-preserving surgery and non-uterine-preserving surgery groups were 39.8 and 57.8 years, respectively. After inverse probability of treatment weighting adjustments, no significant differences in overall survival (p = 0.205) or recurrence-free survival (p=0.071) were observed between the uterine-preserving surgery and non-uterine-preserving surgery groups. Estimated 10-year overall survival rates were 98.7 % in the uterine-preserving surgery group and 95.9 % in the non-uterine-preserving surgery group, and 10-year recurrence-free survival rates were 87.2 % in the uterine-preserving surgery group and 78.2 % in the non-uterine-preserving surgery group. Uterine-preserving surgery did not significantly affect the site of tumour recurrence. CONCLUSION: Uterine-preserving surgery may be a feasible surgical option for patients with stage I sex cord-stromal tumours. Further research is needed to guarantee prognostic accuracy and develop effective therapeutic approaches for sex cord-stromal tumours.

DOI： 10.1016/j.ejogrb.2020.09.009

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Impact of uterus-preserving surgery on Stage I primary mucinous epithelial ovarian carcinoma: A multi-institutional study with propensity score-weighted analysis. International journal

Masato Yoshihara, Hiroaki Kajiyama, Satoshi Tamauchi, Shohei Iyoshi, Akira Yokoi, Shiro Suzuki, Michiyasu Kawai, Tetsuro Nagasaka, Kunihiko Takahashi, Shigeyuki Matsui, Fumitaka Kikkawa

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Vol. 150 ( 2 ) page： 177 - 183 2020.8

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OBJECTIVE: To investigate the clinical characteristics of women with Stage I primary mucinous epithelial ovarian carcinoma (mEOC) and evaluate the impact of uterus-preserving surgery (UPS) in terms of survival prognosis. METHODS: A regional multi-institutional retrospective study conducted between January 1986 and March 2017 by reviewing records of the Tokai Ovarian Tumor Study Group. Clinical and pathologic data and survival outcomes were assessed for women with Stage I primary mEOC. The baseline imbalance between women with and those without UPS was adjusted by an inverse probability of treatment weighting method using the propensity score (PS) of independent clinical variables. RESULTS: Among 4730 women with malignant ovarian tumors, 185 had Stage I primary mEOC and were included in the study. The mean age was 47.6 years (range 12-87 years), and 56 (30.3%) women underwent UPS. After PS-based adjustment, women in the UPS group did not have a poorer prognosis regarding overall survival (P=0.776) or recurrence-free survival (P=0.683). Even after age stratification, there was no statistical difference in survival outcomes between the UPS and non-UPS groups. CONCLUSION: UPS was not associated with decreased survival and may be a treatment option for women with Stage I primary mEOC irrespective of age.

DOI： 10.1002/ijgo.13244

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悪性腹水における腫瘍集団の遊走人類の旅に似た卵巣癌の腹膜播種に関する新規メカニズム(Tumoral caravan migrating in malignant ascites: A novel mechanism of peritoneal dissemination of ovarian cancer resembling anthropological journey)

Yoshihara Masato, Kajiyama Hiroaki, Sugiyama Mai, Koya Yoshihiro, Kitami Kazuhisa, Iyoshi Shohei, Uno Kaname, Nawa Akihiro, Kikkawa Fumitaka

The Journal of Obstetrics and Gynaecology Research Vol. 46 ( 8 ) page： 1565 - 1565 2020.8

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活性型ビタミンDのドラッグリポジショニングによる新たな治療戦略卵巣癌の腹膜播種を促進する腫瘍誘導性のmesothelial-mesenchymal transition阻害剤の可能性(Novel therapeutic strategy using drug repositioning of active vitamin D; A possible inhibitor of the tumor-inducible mesothelial-mesenchymal-transition accelerating peritoneal dissemination in ovarian cancer)

Kitami Kazuhisa, Kajiyama Hiroaki, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Iyoshi Shohei, Uno Kaname, Nawa Akihiro, Kikkawa Fumitaka

The Journal of Obstetrics and Gynaecology Research Vol. 46 ( 8 ) page： 1494 - 1495 2020.8

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腹膜播種のニッチで卵巣癌を休眠状態にするために癌関連中皮細胞が果たす重要な役割(Critical role of cancer associated mesothelial cells to generate dormant ovarian cancer cells in the niche of peritoneal dissemination)

Uno Kaname, Yoshihara Masato, Iyoshi Shohei, Kitami Kazuhisa, Sugiyama Mai, Koya Yoshihiro, Nawa Akihiro, Kajiyama Hiroaki, Kikkawa Fumitaka

The Journal of Obstetrics and Gynaecology Research Vol. 46 ( 8 ) page： 1494 - 1494 2020.8

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腹膜脱分化脂肪細胞由来間葉系細胞を標的とした新規戦略脂肪-腫瘍微小環境における卵巣癌のconverted supporter(Novel strategy for targeting peritoneal dedifferentiated adipocyte derived mesenchymal cells; converted supporter of ovarian cancer in a lipo-tumoral microenvironment)

Iyoshi Shohei, Kajiyama Hiroaki, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Kitami Kazuhisa, Uno Kaname, Nawa Akihiro, Kikkawa Fumitaka

The Journal of Obstetrics and Gynaecology Research Vol. 46 ( 8 ) page： 1565 - 1565 2020.8

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悪性腹水を移動する腫瘍キャラバン人類学的な旅に似た卵巣癌の腹膜播種に関する新規メカニズム(Tumoral caravan migrating in malignant ascites:A novel mechanism of peritoneal dissemination of ovarian cancer resembling anthropological journey)

Yoshihara Masato, Kajiyama Hiroaki, Sugiyama Mai, Koya Yoshihiro, Kitami Kazuhisa, Iyoshi Shohei, Uno Kaname, Nawa Akihiro, Kikkawa Fumitaka

日本産科婦人科学会雑誌 Vol. 72 ( 臨増 ) page： S - 240 2020.3

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癌関連中皮細胞が腹膜播種のニッチで休眠卵巣癌細胞を生成するために果たす重要な役割(Critical role of cancer associated mesothelial cells to generate dormant ovarian cancer cells in the niche of peritoneal dissemination)

Uno Kaname, Yoshihara Masato, Iyoshi Shohei, Kitami Kazuhisa, Sugiyama Mai, Koya Yoshihiro, Nawa Akihiro, Kajiyama Hiroaki, Kikkawa Fumitaka

日本産科婦人科学会雑誌 Vol. 72 ( 臨増 ) page： S - 169 2020.3

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活性型ビタミンDのドラッグリポジショニングを利用した新規治療戦略卵巣癌の腹膜播種を促進する腫瘍誘導性上皮間葉転換を阻害できる可能性(Novel therapeutic strategy using drug repositioning of active vitamin D;A possible inhibitor of the tumor-inducible mesothelial-mesenchymal-transition accelerating peritoneal dissemination in ovarian cancer)

Kitami Kazuhisa, Kajiyama Hiroaki, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Iyoshi Shohei, Uno Kaname, Nawa Akihiro, Kikkawa Fumitaka

日本産科婦人科学会雑誌 Vol. 72 ( 臨増 ) page： S - 170 2020.3

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腹膜脱分化脂肪組織由来間葉系細胞を標的とするための新規戦略脂肪-腫瘍微小環境における卵巣癌のconverted supporter(Novel strategy for targeting peritoneal dedifferentiated adipocyte derived mesenchymal cells;converted supporter of ovarian cancer in a lipo-tumoral microenvironment)

Iyoshi Shohei, Kajiyama Hiroaki, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Kitami Kazuhisa, Uno Kaname, Nawa Akihiro, Kikkawa Fumitaka

日本産科婦人科学会雑誌 Vol. 72 ( 臨増 ) page： S - 240 2020.3

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Prognostic impact of pelvic and para-aortic lymphadenectomy on clinically-apparent stage I primary mucinous epithelial ovarian carcinoma: a multi-institutional study with propensity score-weighted analysis. International journal Open Access

Masato Yoshihara, Hiroaki Kajiyama, Satoshi Tamauchi, Shohei Iyoshi, Akira Yokoi, Shiro Suzuki, Michiyasu Kawai, Tetsuro Nagasaka, Kunihiko Takahashi, Shigeyuki Matsui, Fumitaka Kikkawa

Japanese journal of clinical oncology Vol. 50 ( 2 ) page： 145 - 151 2020.2

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BACKGROUND: The exact impact of full-staging lymphadenectomy on patients with primary mucinous epithelial ovarian carcinoma confined to the ovary is still unclear. In this study, we investigated the prognostic impact of lymphadenectomy covering both pelvic and para-aortic lymph nodes in patients with clinically-apparent stage I mucinous epithelial ovarian carcinoma, using data from multi-institutions under a central pathological review system and analyses with a propensity score-based method. METHODS: We conducted a regional multi-institutional retrospective study between 1986 and 2017. Among 4730 patients with malignant ovarian tumors, a total of 186 women with mucinous epithelial ovarian carcinoma were eligible. We evaluated differences in survival outcomes between patients with both pelvic and para-aortic lymphadenectomy and those with only pelvic lymphadenectomy and/or clinical lymph node evaluation. To analyze the therapeutic effects, the baseline imbalance between patients with both pelvic and para-aortic lymphadenectomy and others was adjusted with an inverse probability of treatment weighting using propensity score involving independent clinical variables. RESULTS: Fifty-five patients received both pelvic and para-aortic lymphadenectomy. With PS-based adjustment, both pelvic and para-aortic lymphadenectomy did not have additive effects regarding overall survival (P = 0.696) and recurrence-free survival (P = 0.978). Multivariate analysis similarly showed no significant impact of both pelvic and para-aortic lymphadenectomy on their prognosis. CONCLUSIONS: The effect of pelvic and para-aortic lymphadenectomy is limited for clinically-apparent stage I primary mucinous epithelial ovarian carcinoma as long as full peritoneal and clinical lymph node evaluations are conducted. The results of this study should be used as the basis for additional studies, including prospective trials.

DOI： 10.1093/jjco/hyz163

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REDUCED RESPONSE TO CONTROLLED OVARIAN STIMULATION AFTER RADICAL TRACHELECTOMY

Tamauchi, S; Kajiyama, H; Osuka, S; Moriyama, Y; Yoshihara, M; Iyoshi, S; Yoshida, K; Ikeda, Y; Yoshikawa, N; Nishino, K; Niimi, K; Suzuki, S; Kikkawa, F

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 29 page： A269 - A270 2019.11

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DOI： 10.1136/ijgc-2019-ESGO.469

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Chronic tubal pregnancy manifesting as a heterogeneous adnexal mass with prominent neovascularization in a woman with a negative serum β-human chorionic gonadotropin level. International journal

Kazuhisa Fujita, Shohei Iyoshi, Kazuko Watanabe, Akihiro Takeda

The journal of obstetrics and gynaecology research Vol. 45 ( 3 ) page： 729 - 733 2019.3

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A 41-year-old woman (gravida 2, para 1) underwent elective termination of pregnancy at approximately 7 weeks of gestation. At 1 month after the elective abortion, she was referred due to abnormal results in a cervical cytological examination. Transvaginal ultrasonography showed a heterogeneous mass of 16 mm in diameter in the left adnexal region. At 3 months after her referral, the asymptomatic left adnexal mass had increased to 55 mm in diameter. Prominent vascular flow was detected in the solid portion by color Doppler ultrasonography. Magnetic resonance imaging showed suspected hemorrhage in the left adnexal cystic mass. Three-dimensional computerized tomographic angiography showed the prominent development of tortuous blood vessels in the left adnexal region, which originated from the left ovarian artery. The patient had a negative β-human chorionic gonadotropin (hCG) level. Left salpingectomy was performed by a single-port laparoscopic approach. A pathological examination revealed degenerated villous tissue with β-hCG-positive syncytiotrophoblasts.

DOI： 10.1111/jog.13869

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Mesothelial cells create invasion frontier in peritoneal metastasis of epithelial ovarian cancer

Iyoshi, S; Kajiyama, H; Yoshihara, M; Yamakita, Y; Sugiyama, M; Koya, Y; Ryu, B; Kikkawa, F

CANCER SCIENCE Vol. 109 page： 282 - 282 2018.12

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Superselective microcoil embolization of the vasa recta of sigmoid artery for hemorrhaging after laparoscopic adnexectomy for corpus luteum hematoma with severe adhesion. International journal

Shohei Iyoshi, Wataru Koike, Akihiro Takeda

The journal of obstetrics and gynaecology research Vol. 44 ( 8 ) page： 1487 - 1491 2018.8

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A 44-year-old multipara woman was referred because of the sudden onset of left lower abdominal pain. Corpus luteum hematoma was suspected and conservatively managed. Two days later, due to worsening of abdominal symptoms, emergency laparoscopic surgery was performed. Severe pelvic adhesion around the left ovary forming corpus luteum hematoma was identified. After adhesiolysis, which was complicated by massive bleeding, left adnexectomy was performed. Hemostasis was achieved by the coagulation of bleeding vessels, followed by spraying fibrin glue with the placement of oxidized cellulose cotton for bleeding oozing from dissected surface. Two hours after surgery, emergency computed tomography performed due to the development of hemodynamic instability demonstrated extravasation from the versa recta of the sigmoid artery. After the confirmation of hemorrhaging, superselective catheterization to the bleeding vessel followed by embolization by platinum microcoils were performed. Hemodynamic stability was immediately achieved, and the postoperative course was uneventful without manifestation of bowel ischemia.

DOI： 10.1111/jog.13689

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Asymmetrical distribution of choline phospholipids revealed by click chemistry and freeze-fracture electron microscopy. International journal

Shohei Iyoshi, Jinglei Cheng, Tsuyako Tatematsu, Sho Takatori, Masayasu Taki, Yukio Yamamoto, Adrian Salic, Toyoshi Fujimoto

ACS chemical biology Vol. 9 ( 10 ) page： 2217 - 2222 2014.10

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Choline-containing phospholipids (Cho-PLs) are major components of all cellular membranes. We developed an electron microscopic technique to investigate the poorly understood problem of how Cho-PLs are distributed between membrane leaflets. Our method relies on generating freeze-fracture replicas of cells metabolically labeled with the choline analog, propargylcholine, followed by "click" reaction to conjugate biotin to propargylcholine head groups, and immunodetection of biotin with colloidal gold. Using this method in budding yeast, we found that, surprisingly, the Golgi and plasma membrane display a cytoplasmic leaflet-dominant asymmetry in Cho-PL distribution; in contrast, Cho-PLs are evenly distributed between the exoplasmic and cytoplasmic leaflets of other organelle membranes. In mammalian culture cells, the plasma membrane shows symmetrical Cho-PL distribution between leaflets, suggesting a fundamental difference between yeast and mammals. Our method should be expandable to other classes of lipids and will be useful for deciphering the mechanism responsible for generating lipid asymmetry in biological membranes.

DOI： 10.1021/cb500558n

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Rosamine-based fluorescent sensor with femtomolar affinity for the reversible detection of a mercury ion. International journal

Masayasu Taki, Kazushi Akaoka, Shohei Iyoshi, Yukio Yamamoto

Inorganic chemistry Vol. 51 ( 24 ) page： 13075 - 7 2012.12

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A Hg(2+)-selective fluorescent sensor, RosHg, has been developed based on a rosamine platform. RosHg exhibited a ∼20-fold increase in fluorescence emission upon binding with Hg(2+), and the enhanced fluorescence was immediately decreased when glutathione was added to a solution of the Hg-RosHg complex. The dissociation constant for the Hg(2+) complex was determined to be 0.10 fM by using a set of Hg(2+)/Mg(2+)/ethylenediaminetetraacetic acid buffer solutions. Confocal microscopy experiments demonstrated that this sensor can monitor changes of the Hg(2+) level in the mitochondria of living cells.

DOI： 10.1021/ic301822r

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Development of a cholesterol-conjugated fluorescent sensor for site-specific detection of zinc ion at the plasma membrane. International journal

Shohei Iyoshi, Masayasu Taki, Yukio Yamamoto

Organic letters Vol. 13 ( 17 ) page： 4558 - 61 2011.9

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A cholesterol-conjugated fluorescence Zn(2+) sensor based on the fluorescein platform was designed and synthesized. The cholesterol moiety is essential for localizing the Zn(2+) sensor to the cell membrane, allowing the sensor to probe changes in the Zn(2+) concentration in a localized area of the cell.

DOI： 10.1021/ol201746p

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Electron microscopic visualization of the filament binding mode of actin-binding proteins. International journal

Takuto Ito, Tasuku Hirayama, Masayasu Taki, Shohei Iyoshi, Shuheng Dai, Shuichi Takeda, Chieko Kimura-Sakiyama, Toshiro Oda, Yukio Yamamoto, Yuichiro Maéda, Akihiro Narita

Journal of molecular biology Vol. 408 ( 1 ) page： 26 - 39 2011.4

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A large number of actin-binding proteins (ABPs) regulate various kinds of cellular events in which the superstructure of the actin cytoskeleton is dynamically changed. Thus, to understand the actin dynamics in the cell, the mechanisms of actin regulation by ABPs must be elucidated. Moreover, it is particularly important to identify the side, barbed-end or pointed-end ABP binding sites on the actin filament. However, a simple, reliable method to determine the ABP binding sites on the actin filament is missing. Here, a novel electron microscopic method for determining the ABP binding sites is presented. This approach uses a gold nanoparticle that recognizes a histidine tag on an ABP and an image analysis procedure that can determine the polarity of the actin filament. This method will facilitate future study of ABPs.

DOI： 10.1016/j.jmb.2011.01.054

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Human spire interacts with the barbed end of the actin filament. International journal

Takuto Ito, Akihiro Narita, Tasuku Hirayama, Masayasu Taki, Shohei Iyoshi, Yukio Yamamoto, Yuichiro Maéda, Toshiro Oda

Journal of molecular biology Vol. 408 ( 1 ) page： 18 - 25 2011.4

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Spire is an actin nucleator that initiates actin polymerization at a specific place in the cell. Similar to the Arp2/3 complex, spire was initially considered to bind to the pointed end of the actin filament when it generates a new actin filament. Subsequently, spire was reported to be associated with the barbed end (B-end); thus, there is still no consensus regarding the end with which spire interacts. Here, we report direct evidence that spire binds to the B-end of the actin filament, under conditions where spire accelerates actin polymerization. Using electron microscopy, we visualized the location of spire bound to the filament by gold nanoparticle labeling of the histidine-tagged spire, and the polarity of the actin filament was determined by image analysis. In addition, our results suggest that multiple spires, linked through one gold nanoparticle, enhance the acceleration of actin polymerization. The B-end binding of spire provides the basis for understanding its functional mechanism in the cell.

DOI： 10.1016/j.jmb.2010.12.045

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Development of highly sensitive fluorescent probes for detection of intracellular copper(I) in living systems. International journal

Masayasu Taki, Shohei Iyoshi, Akio Ojida, Itaru Hamachi, Yukio Yamamoto

Journal of the American Chemical Society Vol. 132 ( 17 ) page： 5938 - 9 2010.5

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We describe here the new copper-selective fluorescent probes FluTPA1 and FluTPA2, in which the tetradentate ligand tris[(2-pyridyl)methyl]amine (TPA) is connected to a reduced form of a fluorescein platform through a benzyl ether linkage. These probes selectively react with copper ions in the presence of submillimolar glutathione and emit intense green fluorescence from the reaction product, O-methylfluorescein. Confocal images of live cells further show that FluTPA2 is membrane-permeable and allows visualization of Cu(I) present in living cells.

DOI： 10.1021/ja100714p

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Fluorescence imaging of intracellular cadmium using a dual-excitation ratiometric chemosensor. International journal

Masayasu Taki, Mika Desaki, Akio Ojida, Shohei Iyoshi, Tasuku Hirayama, Itaru Hamachi, Yukio Yamamoto

Journal of the American Chemical Society Vol. 130 ( 38 ) page： 12564 - 5 2008.9

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We described here a coumarin-based dual-excitation ratiometric probe for cadmium, CadMQ. This fluorescence sensor has high quantum yields of 0.59 and 0.70 in the metal-free and Cd2+-bound forms, respectively, and has a dissociation constant of 0.16 nM for Cd2+. CadMQ is cell permeable and locates within the acidic compartments of the cells. We further show that CadMQ is a useful tool to ratiometrically probe the change in the intracellular Cd2+ levels with the use of two excited wavelengths.

DOI： 10.1021/ja803429z

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Rosamine-based fluorescent chemosensor for selective detection of silver(I) in an aqueous solution. International journal

Shohei Iyoshi, Masayasu Taki, Yukio Yamamoto

Inorganic chemistry Vol. 47 ( 10 ) page： 3946 - 8 2008.5

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The synthesis and photophysical properties of a rosamine-based fluorescent chemosensor, RosAg, for detecting Ag ion in an aqueous solution are described. This fluorescent sensor has a negligible quantum yield (<0.005) in the absence of Ag(+), whereas a significant increase in fluorescence is observed upon complexation with Ag(+) under physiological conditions. The crystal structure of the silver complex with the chelator moiety of RosAg reveals a trigonal-planar coordination geometry in which three S atoms occupy the metal center. Although a strong coordinative interaction of Ag-N is not observed in the crystal structure, the (1)H NMR experiments suggest that aniline nitrogen is likely to be associated with the Ag(+) center in the solution state. This may inhibit the photoinduced electron transfer process and result in the enhancement of fluorescence.

DOI： 10.1021/ic800442y

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Synthesis of a new bifunctionalised fluorescent label and physical properties of the bound form on model peptide of troponin C. International journal

Tasuku Hirayama, Shohei Iyoshi, Masayasu Taki, Yuichiro Maeda, Yukio Yamamoto

Organic & biomolecular chemistry Vol. 5 ( 13 ) page： 2040 - 2045 2007

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A new bifunctional fluorescent label, BRos, was synthesised in order to monitor protein dynamics using fluorescence microscopy, and the photophysical properties were compared with those of bifunctionalised rhodamine, BRho. In a labelling experiment with a model peptide of troponin C, which regulates muscle contraction and relaxation, it was found that BRos was bound to the peptide through two linkages and provided a homogeneous compound, whereas BRho gave a pair of diastereomers having different physical properties in NMR and HPLC analyses.

DOI： 10.1039/b705704k

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MISC 199

子宮頸がんに対する同時化学放射線療法にて寛解約20年後に外陰部Bowen病と膣がんを発症した1例

大川明日香, 清水裕介, 嶋谷拓真, 菱川里沙, 宮本絵美里, 窪川芽衣, 國島温志, 安井裕子, 田中秀明, 伊吉祥平, 吉田康将, 吉原雅人, 玉内学志, 横井暁, 池田芳紀, 芳川修久, 新美薫, 梶山広明

東海産科婦人科学会雑誌 Vol. 61 2025

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妊娠部位の確認に子宮鏡が有用であった頸管妊娠流産後HCG再上昇を認めた2症例

伊吉祥平, 太田肇, 小林裕太, 足立健敏, 安井裕子, 竹田健彦, 三宅菜月, 曽根原玲菜, 村岡彩子, 中村智子, 大須賀智子, 梶山広明

東海産科婦人科学会雑誌 Vol. 61 2025

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Retained products of conception(RPOC)の致死的出血予測:多施設共同研究からの知見

中村智子, 可世木聡, 曽根原玲菜, 西田一貴, クレティアンバジル, 北原慈和, 白崎茉莉, 古井憲作, 上田真子, 河井啓一郎, 竹田健彦, 関友望, 伊吉祥平, 三宅菜月, 村岡彩子, 大須賀智子, 後藤真紀, 岩瀬明, 梶山広明

日本生殖医学会雑誌 Vol. 70 ( 1/2 ) 2025

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I期上皮性卵巣癌患者の再発後生存に対する妊孕性温存術の影響

吉原雅人, 茂木一将, 宮本絵美里, 伊吉祥平, 宇野枢, 藤本裕基, 芳川修久, 梶山広明

東海産科婦人科学会雑誌 Vol. 61 2025

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実臨床向き新概念「抗癌剤の貢献期間」による再発漿液性卵巣癌に対する抗癌剤の有効性の評価

前田修, 本岡大社, 伊藤真文, 宮本絵美里, 伊吉祥平, 吉原雅人, 池田芳紀, 芳川修久, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 66回 page： 326 - 326 2024.7

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メフリン陽性癌関連線維芽細胞は腹膜播種抑制制御を介して進行卵巣癌に抗腫瘍効果を示す(Oncology-Basic Research 2 Meflin-positive cancer-associated fibroblasts exhibit antitumor effect in advanced ovarian cancer through regulation of inhibition of peritoneal dissemination)

Miyamoto Emiri, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Fujimoto Hiroki, Iyoshi Shohei, Mogi Kazumasa, Uno Kaname, Kitami Kazuhisa, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 76 ( 臨増 ) page： S - 257 2024.2

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難治性卵巣癌の腹膜進展に対する潜在的治療標的としての癌関連線維症(Cancer-associated fibrosis as a potential therapeutic target for peritoneal progression of refractory ovarian cancer)

Yoshihara Masato, Fujimoto Hiroki, Iyoshi Shohei, Miyamoto Emiri, Mogi Kazumasa, Uno Kaname, Kitami Kazuhisa, Sugiyama Mai, Koya Yoshihiro, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 76 ( 臨増 ) page： S - 267 2024.2

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腫瘍内血管の供給源としてのがん関連中皮細胞は卵巣がんの潜在的治療標的である(Cancer-associated mesothelial cells as a source of intratumoral vessels are potential therapeutic targets for ovarian cancer)

Mogi Kazumasa, Yoshihara Masato, Miyamoto Emiri, Fujimoto Hiroki, Uno Kaname, Iyoshi Shohei, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 76 ( 臨増 ) page： S - 349 2024.2

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白金製剤の分布による白金製剤耐性卵巣癌の新たな定義(New definition of platinum resistant ovarian cancer through platinum distribution)

Uno Kaname, Yoshihara Masato, Yamakita Yoshihiko, Miyamoto Emiri, Fujimoto Hiroki, Iyoshi Shohei, Mogi Kazumasa, Sugiyama Mai, Koya Yoshihiro, Yoshikawa Nobuhisa, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 76 ( 臨増 ) page： S - 238 2024.2

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卵巣癌腹膜転移における脂肪組織の標的脂肪細胞脱分化の腫瘍促進的役割と悪性腹水による脱分化過程阻害剤スクリーニングのための新規脂質滴蛍光センサーの開発(Targeting adipose tissue in ovarian cancer peritoneal metastasis; A tumor promoting role of adipocyte dedifferentiation and the development of a novel lipid droplet fluorescent sensor for inhibitor screening of dedifferentiation process caused by malignant ascites)

Iyoshi Shohei, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Kitami Kazuhisa, Miyamoto Emiri, Fujimoto Hiroki, Uno Kaname, Mogi Kazumasa, Kajiyama Hiroaki

日本産科婦人科学会雑誌 Vol. 76 ( 臨増 ) page： S - 238 2024.2

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Development of mesothelial cell-targeted therapy to overcome peritoneal dissemination of refractory ovarian cancer

吉原雅人, 宮本絵美里, 茂木一将, 藤本裕基, 伊吉祥平, 宇野枢, 國島温志, 小屋美博, 北見和久, 梶山広明

日本癌学会学術総会抄録集(Web) Vol. 83rd 2024

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Toward Overcoming Chemotherapy Hormesis Induced by the Microenvironment of Refractory Ovarian Cancer

玉内学志, 吉田康将, 茂木一将, 伊吉祥平, 吉原雅人, 横井暁, 梶山広明

日本癌学会学術総会抄録集(Web) Vol. 83rd 2024

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Metastatic units in ascites drive peritoneal dissemination and therapeutic resistance in advanced ovarian cancer

早川紗生, 吉原雅人, 伊吉祥平, 茂木一将, 宮本絵美里, 藤本裕基, 宇野枢, 北見和久, 野村怜史, 小屋美博, 林舞阿, 梶山広明

日本癌学会学術総会抄録集(Web) Vol. 83rd 2024

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Meflin-positive cancer-associated fibroblasts exhibit anti-tumor effects in advanced ovarian cancer.

宮本絵美里, 吉原雅人, 小屋美博, 藤本裕基, 伊吉祥平, 茂木一将, 宇野枢, 北見和久, 榎本篤, 梶山広明

日本癌学会学術総会抄録集(Web) Vol. 83rd 2024

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進行卵巣癌でMeflin陽性癌関連線維芽細胞が腫瘍進展,生命予後に与える影響

宮本絵美里, 吉原雅人, 藤本裕基, 伊吉祥平, 茂木一将, 宇野枢, 北見和久, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web) Vol. 66th 2024

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血清LDH値を子宮体癌患者のバイオマーカーに利用する可能性についての検討

窪川芽衣, 芳川修久, 松川哲也, 服部諭美, 伊吉祥平, 吉田康将, 茂木一将, 吉原雅人, 玉内学志, 横井暁, 新美薫, 梶山広明

日本癌治療学会学術集会(Web) Vol. 62nd 2024

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腹腔鏡下予防的性腺切除術により診断された卵巣未分化胚細胞腫を伴うXY純粋型性腺形成不全症の1例

伊吉祥平, 大須賀智子, 畠山未来, 菱川里沙, 河井啓一郎, 窪川芽衣, 加藤彬人, 宮本絵美里, 竹田健彦, 安井裕子, 可世木聡, 関友望, 三宅菜月, 曽根原玲菜, 村岡彩子, 中村智子, 梶山広明

愛知産科婦人科学会学術講演会プログラム Vol. 119th 2024

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Elucidation of a novel mechanism of ovarian cancer progression with tumor-associated fibrosis (TAF)

藤本裕基, 藤本裕基, 吉原雅人, 小屋美博, 宮本絵美里, 茂木一将, 宇野枢, 宇野枢, 伊吉祥平, 伊吉祥平, 北見和久, 那波明宏, 梶山広明

日本癌学会学術総会抄録集(Web) Vol. 83rd 2024

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Targeting adipocytes at tumor microenvironment of ovarian cancer omental metastasis

伊吉祥平, 伊吉祥平, 多喜正泰, 有賀隆世, 佐藤綾人, 吉原雅人, 小屋美博, 宮本絵美里, 藤本裕基, 國島温志, 宇野枢, 茂木一将, 北見和久, 梶山広明

日本癌学会学術総会抄録集(Web) Vol. 83rd 2024

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索状性腺に未分化胚細胞腫を認めたXY純粋型性腺形成不全症

竹田健彦, 伊吉祥平, 大須賀智子, 阮加里, 上田真子, 河井啓一郎, 関友望, 可世木聡, 曽根原玲菜, 三宅菜月, 村岡彩子, 中村智子, 梶山広明

臨床内分泌代謝Update抄録集(Web) Vol. 34th 2024

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生殖医療の最新潮流とその一歩先最新潮流:卵巣予備能から着床まで【配偶子と授精・胚発育】高感度AMH測定

大須賀智子, 伊吉祥平, 伊吉祥平

臨床婦人科産科 Vol. 78 ( 11 ) 2024

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当院における外陰部扁平上皮癌の治療成績と予後の検討

國島温志, 池田芳紀, 伊吉祥平, 吉田康将, 吉原雅人, 玉内学志, 清水裕介, 横井暁, 芳川修久, 新美薫, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web) Vol. 66th 2024

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完全腫瘍切除された上皮性卵巣癌患者での組織型別腫瘍学的転帰の検討

茂木一将, 吉原雅人, 宮本絵美里, 藤本裕基, 藤本裕基, 宇野枢, 宇野枢, 田野翔, 伊吉祥平, 北見和久, 芳川修久, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web) Vol. 66th 2024

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女性ホルモン関連製剤投与での留意点

中村智子, 上田真子, 河井啓一郎, 竹田健彦, 可世木聡, 関友望, 伊吉祥平, 曽根原玲菜, 三宅菜月, 村岡彩子, 大須賀智子, 梶山広明

臨床内分泌代謝Update抄録集(Web) Vol. 34th 2024

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卵巣癌腹膜播種における好中球組織内浸潤が生命予後へ及ぼす影響

宮本絵美里, 吉原雅人, 藤本裕基, 伊吉祥平, 茂木一将, 北見和久, 宇野枢, 梶山広明

日本癌治療学会学術集会(Web) Vol. 62nd 2024

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卵巣癌化学療法の変遷と維持療法の影響

茂木一将, 茂木一将, 吉原雅人, 宮本絵美里, 藤本裕基, 國島温志, 伊吉祥平, 吉田康将, 玉内学志, 横井暁, 芳川修久, 新美薫, 梶山広明

日本癌治療学会学術集会(Web) Vol. 62nd 2024

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Exploring the role of vitamin D derivatives in inhibiting peritoneal dissemination of ovarian cancer

林舞阿, 吉原雅人, 伊吉祥平, 茂木一将, 宮本絵美里, 藤本裕基, 宇野枢, 北見和久, 野村怜史, 小屋美博, 早川紗生, 梶山広明

日本癌学会学術総会抄録集(Web) Vol. 83rd 2024

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不妊外来における尿蛋白定量検査の必要性

河井啓一郎, 曽根原玲菜, 上田真子, 竹田健彦, 可世木聡, 関友望, 伊吉祥平, 三宅菜月, 村岡彩子, 中村智子, 大須賀智子, 梶山弘明

愛知産科婦人科学会学術講演会プログラム Vol. 120th (CD-ROM) 2024

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マウス卵巣癌高播種株の確立と腹膜播種性向に与えるADAM/MMP分子群の役割

國島温志, 伊吉祥平, 伊吉祥平, 宮本絵美里, 藤本裕基, 宇野枢, 北見和久, 北見和久, 茂木一将, 吉原雅人, 山北由彦, 小屋美博, 小屋美博, 梶山広明

日本病態プロテアーゼ学会学術集会プログラム抄録集 Vol. 29th (CD-ROM) 2024

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「癌関連線維化(tumor-associated fibrosis;TAF)」による新たな腹膜播種進展メカニズムの解明

藤本裕基, 藤本裕基, 吉原雅人, 宮本絵美里, 伊吉祥平, 宇野枢, 茂木一将, 北見和久, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web) Vol. 66th 2024

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I期上皮性卵巣癌患者に対する妊孕性温存術の再発後生存への影響:後方視的多施設共同研究

吉原雅人, 宮本絵美里, 伊吉祥平, 茂木一将, 宇野枢, 藤本裕基, 北見和久, 北見和久, 吉田康将, 玉内学志, 横井暁, 芳川修久, 新美薫, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web) Vol. 66th 2024

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Development of an early diagnosis system for ovarian tumors using Artificial Intelligence

國島温志, 池田芳紀, 池田芳紀, 稲葉大樹, 小泉憲裕, 後藤万由子, 村松令糸生, 橋本瑞樹, 伊吉祥平, 吉田康将, 茂木一将, 吉原雅人, 玉内学志, 横井暁, 芳川修久, 新美薫, 梶山広明

日本癌学会学術総会抄録集(Web) Vol. 83rd 2024

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9-oxo-10,12-octadecadienoic acid suppresses the proliferation of human cervical cancer cells

茂木一将, 小屋美博, 吉原雅人, 國島温志, 宮本絵美里, 藤本裕基, 伊吉祥平, 宇野枢, 北見和久, 玉内学志, 横井暁, 新美薫, 富田弘之, 那波明宏, 梶山広明

日本癌学会学術総会抄録集(Web) Vol. 83rd 2024

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AYA世代卵巣癌患者における予後因子と妊孕性温存手術の影響

宮本絵美里, 吉原雅人, 茂木一将, 伊吉祥平, 藤本裕基, 宇野枢, 北見和久, 芳川修久, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 61回 page： O70 - 1 2023.10

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「SIGシンポジウム子宮内膜症合併不妊症の取り扱い-日本生殖医学会会員アンケート結果から見えた課題-」子宮内膜症に関するオーバービュー

中村智子, 竹田健彦, 関友望, 可世木聡, 矢吹淳司, 田中秀明, 曽根原玲菜, 伊吉祥平, 三宅菜月, 村岡彩子, 大須賀智子, 梶山広明

日本生殖医学会雑誌 Vol. 68 ( 4 ) page： 336 - 336 2023.10

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卵巣癌における腹水量の治療予後に対する影響大規模コホートを用いた多施設共同研究

伊吉祥平, 木村真梨子, 吉原雅人, 宮本絵美里, 茂木一将, 宇野枢, 藤本裕基, 芳川修久, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 61回 page： O68 - 1 2023.10

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内視鏡・ロボット手術における教育法を再考する微細な構造をよく見て考えよう手術の道標

池田芳紀, 植草良輔, 松川哲也, 可世木聡, 長尾有佳里, 安井裕子, 伊吉祥平, 田野翔, 吉田康将, 吉原雅人, 玉内学志, 清水裕介, 横井暁, 芳川修久, 新美薫, 中村智子, 大須賀智子, 梶山広明

東海産婦人科内視鏡手術研究会雑誌 Vol. 11 page： 28 - 28 2023.10

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内視鏡・ロボット手術における教育法を再考する微細な構造をよく見て考えよう手術の道標

池田芳紀, 植草良輔, 松川哲也, 可世木聡, 長尾有佳里, 安井裕子, 伊吉祥平, 田野翔, 吉田康将, 吉原雅人, 玉内学志, 清水裕介, 横井暁, 芳川修久, 新美薫, 中村智子, 大須賀智子, 梶山広明

東海産婦人科内視鏡手術研究会雑誌 Vol. 11 page： 28 - 28 2023.10

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ベンチワークから臨床へ繋げる婦人科がん治療に対する新たな展望進行卵巣癌腹膜播種の病勢制御を目指した腫瘍随伴性線維化機構の解明に関する研究

吉原雅人, 藤本裕基, 宮本絵美里, 茂木一将, 伊吉祥平, 宇野枢, 北見和久, 杉山麻衣, 山北由彦, 小屋美博, 那波明宏, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 61回 page： OWS11 - 1 2023.10

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【代謝】代謝とがん肥満と卵巣がん

伊吉祥平, 吉原雅人, 梶山広明

生体の科学 Vol. 74 ( 5 ) page： 458 - 459 2023.10

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Authorship：Lead author Language：Japanese Publisher：(公財)金原一郎記念医学医療振興財団

＜文献概要＞卵巣がんは腹膜播種という特徴的な進展形式を示す。播種巣の形成に際して,卵巣がん細胞は腹腔内脂肪組織への選択性を示し,そこで脂肪細胞ががん細胞の増殖や進展を促進することがわかっている。肥満が卵巣がんの予後に与える影響については長らく議論があったが,脂肪組織の蓄積が予後不良因子となることを示唆する報告が多い。脂肪組織をターゲットとした新規治療法の確立は他がん腫にも応用できる可能性があり,その開発が求められている。

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完全腫瘍切除された上皮性卵巣がん患者での組織型毎の予後検討

茂木一将, 吉原雅人, 江本遼, 宮本絵美里, 藤本裕基, 宇野枢, 伊吉祥平, 玉内学志, 清水裕介, 横井暁, 池田芳樹, 芳川修久, 新美薫, 松井茂之, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 61回 page： O68 - 5 2023.10

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NGFRは細胞増殖、浸潤を促進し、卵巣癌の進展に寄与する(NGFR contributes progression of ovarian cancer through promoting proliferation and invasion)

宮本絵美里, 小屋美博, 吉原雅人, 杉山麻衣, 伊吉祥平, 北見和久, 宇野枢, 茂木一将, 藤本裕基, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 82回 page： 1701 - 1701 2023.9

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アポトーシスを起こした卵巣癌細胞を貪食した癌関連中皮細胞が宿主抗腫瘍免疫を抑制する可能性(Cancer-associated mesothelial cells that phagocytize apoptotic ovarian cancer cells may suppress anti-cancer immunity)

小屋美博, 北見和久, 吉原雅人, 杉山麻衣, 宇野枢, 茂木一将, 伊吉祥平, 藤本裕基, 宮本絵美里, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 82回 page： 1403 - 1403 2023.9

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がん関連中皮細胞は腫瘍内血管の構成細胞となりうる(CAMs as a source of intratumoral vessels are potential therapeutic targets for ovarian cancer)

茂木一将, 谷口寿章, 吉原雅人, 宮本絵美里, 藤本裕基, 伊吉祥平, 宇野枢, 北見和久, 杉山麻衣, 小屋美博, 富田弘之, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 82回 page： 1180 - 1180 2023.9

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進行卵巣癌の腹膜播種における線維化の特徴解析(The character of tumor-associated fibrosis in peritoneal dissemination of advanced ovarian cancer)

吉原雅人, 宮本絵美里, 伊吉祥平, 茂木一将, 藤本裕基, 杉山麻衣, 北見和久, 小屋美博, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 82回 page： 1166 - 1166 2023.9

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高異型度漿液性卵巣癌患者由来悪性腹水の大規模コホートプロテオミクス解析による分子型サブグループの同定と予後マーカーの探索(Large scale proteomics of malignant ascites in ovarian cancer reveals distinct subgroups and prognostic biomarkers)

伊吉祥平, Dreyer Tobias, 吉原雅人, 山北由彦, Magdolen Viktor, 梶山広明, Schilling Oliver

日本癌学会総会記事 Vol. 82回 page： 439 - 439 2023.9

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AYA世代卵巣癌患者の予後因子の検討傾向スコアマッチング法を用いた後方視的多施設共同研究

宮本絵美里, 吉原雅人, 伊吉祥平, 茂木一将, 宇野枢, 藤本裕基, 北見和久, 芳川修久, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 65回 page： 263 - 263 2023.7

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【卵巣癌維持療法の日本人リアルワールドデータから見えてくるもの】リアルワールドデータからみる卵巣癌化学療法の変遷と維持療法の影響

茂木一将, 吉原雅人, 宮本絵美里, 藤本裕基, 伊吉祥平, 宇野枢, 玉内学志, 横井暁, 清水裕介, 池田芳紀, 芳川修久, 新美薫, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 65回 page： 140 - 140 2023.7

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上皮性卵巣癌における腹水量の治療予後に対する影響大規模コホートを用いた多施設共同研究

木村真梨子, 吉原雅人, 宮本絵美里, 茂木一将, 伊吉祥平, 宇野枢, 藤本裕基, 芳川修久, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 65回 page： 294 - 294 2023.7

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卵巣癌腹水の大規模プロテオミクス解析による分子型サブグループと予後マーカーの探索

伊吉祥平, ドレイヤー・トビアス, 吉原雅人, 山北由彦, マグドレン・ビクター, 梶山広明, シリング・オリバー

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 65回 page： 297 - 297 2023.7

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卵巣癌腹膜播種制御における新規治療戦略 Chondroitin sulfate proteoglycan 4の役割

宇野枢, 小屋美博, 吉原雅人, 北見和久, 伊吉祥平, 茂木一将, 宮本絵美里, 藤本裕基, 山北由彦, 杉山麻衣, 那波明宏, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 65回 page： 296 - 296 2023.7

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上皮性卵巣癌再発後生存に対する妊孕性温存手術の影響傾向スコア逆数重み付け法による後方視的解析

吉原雅人, 北見和久, 茂木一将, 宇野枢, 伊吉祥平, 田野翔, 藤本裕基, 芳川修久, 梶山広明

東海産科婦人科学会雑誌 Vol. 59 page： 445 - 445 2023.3

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AYA世代卵巣癌患者における予後因子と妊孕性温存手術の影響傾向スコアマッチング法を用いた後方視的多施設共同研究

宮本絵美里, 吉原雅人, 伊吉祥平, 茂木一将, 宇野枢, 北見和久, 梶山広明

日本がん・生殖医療学会誌 Vol. 6 ( 1 ) page： 119 - 119 2023.2

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卵巣癌における神経成長受容体NGFR発現は浸潤能・増殖能の亢進を介して悪性形質の獲得と予後不良性に関連する

小屋美博, 宮本絵美里, 杉山麻衣, 吉原雅人, 伊吉祥平, 北見和久, 宇野枢, 茂木一将, 藤本裕基, 山下守, 那波明宏, 梶山広明

日本産科婦人科学会雑誌 Vol. 75 ( 臨増 ) page： S - 368 2023.2

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卵巣癌腹膜播種に対するNotchシグナルを標的とした新規治療戦略の創成

杉山麻衣, 吉原雅人, 小屋美博, 北見和久, 宇野枢, 伊吉祥平, 茂木一将, 藤本裕基, 宮本絵美里, 山下守, 那波明宏, 梶山広明

日本産科婦人科学会雑誌 Vol. 75 ( 臨増 ) page： S - 368 2023.2

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がんの微小環境を考える卵巣癌腹膜微小環境におけるがん関連中皮細胞の系譜追跡と機能解析

茂木一将, 谷口寿章, 山北由彦, 吉原雅人, 宮本絵美里, 藤本裕基, 宇野枢, 伊吉祥平, 北見和久, 杉山麻衣, 小屋美博, 富田弘之, 那波明宏, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 60回 page： WS4 - 9 2022.10

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卵巣癌における癌関連繊維化の意義卵巣癌治療の新たな治療標的の確立に向けて

藤本裕基, 吉原雅人, 山北由彦, 小屋美博, 宮本絵美里, 茂木一将, 宇野枢, 伊吉祥平, 北見和久, 那波明宏, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 60回 page： OF - 3 2022.10

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個別化を踏まえた卵巣がんに対する包括的治療戦略再発卵巣癌における長期生存例の特徴に関する多施設後方視的研究

宮本絵美里, 吉原雅人, 茂木一将, 伊吉祥平, 藤本裕基, 宇野枢, 北見和久, 芳川修久, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 60回 page： OWS12 - 5 2022.10

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がんの進展・浸潤に関与する新たな分子生物学的マーカーの開発卵巣癌腹水の大規模プロテオミクス解析による分子型サブグループと予後マーカーの探索

伊吉祥平, ドレイヤー・トビアス, 吉原雅人, 梶山広明, マグドレン・ビクター, シリング・オリバー

日本癌治療学会学術集会抄録集 Vol. 60回 page： WS11 - 9 2022.10

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悪性腹水中の転移小体による卵巣癌腹膜播種進展および治療抵抗性獲得機構の解明

吉原雅人, 茂木一将, 伊吉祥平, 藤本裕基, 宮本絵美里, 宇野枢, 北見和久, 芳川修久, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 60回 page： YOA O50 - 1 2022.10

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CD271は細胞遊走・浸潤能の亢進を介して卵巣癌悪性化に寄与する(CD271 contributes to progression of ovarian cancer via promoting cell migration and invasion)

宮本絵美里, 小屋美博, 吉原雅人, 杉山麻衣, 伊吉祥平, 北見和久, 宇野枢, 茂木一将, 藤本裕基, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 81回 page： P - 1117 2022.9

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卵巣がん関連中皮細胞の系譜追跡と機能解析(Lineage tracing and functional analysis of ovarian cancer-associated mesothelial cells)

茂木一将, 吉原雅人, 谷口寿章, 山北由彦, 宮本絵美里, 藤本裕基, 北見和久, 伊吉祥平, 宇野枢, 杉山麻衣, 小屋美博, 富田弘之, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 81回 page： P - 2284 2022.9

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卵巣がん細胞を貪食した中皮細胞は抗腫瘍免疫を抑制するシグナルが増強される(Mesothelial cells that phagocytosed ovarian cancer cells have enhanced signals that suppress antitumor immunity)

小屋美博, 北見和久, 吉原雅人, 杉山麻衣, 茂木一将, 宇野枢, 伊吉祥平, 藤本裕基, 宮本絵美里, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 81回 page： P - 2286 2022.9

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Notchシグナルは進行卵巣癌の新規治療標的となり得る(Notch signaling can be a new therapeutic target for advanced ovarian cancer)

杉山麻衣, 吉原雅人, 小屋美博, 北見和久, 宇野枢, 伊吉祥平, 茂木一将, 横井暁, 中村香江, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 81回 page： P - 3060 2022.9

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癌関連繊維化,卵巣癌の浸潤・転移研究における新たなアプローチ(Establishing the novel experimental model of tumor-associated fibrosis for ovarian cancer's metastasis)

藤本裕基, 吉原雅人, 山北由彦, 杉山麻衣, 小屋美博, 宮本絵美里, 茂木一将, 宇野枢, 伊吉祥平, 北見和久, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 81回 page： P - 2285 2022.9

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腹膜誘導性Notchシグナルに起因する腫瘍内不均一性と卵巣癌の新規進展機構(Peritoneum-inducible Notch-dependent intra-tumoral heterogeneity mediates development of metastatic ovarian cancer)

吉原雅人, 杉山麻衣, 小屋美博, 伊吉祥平, 北見和久, 宇野枢, 茂木一将, 藤本裕基, 宮本絵美里, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 81回 page： P - 2110 2022.9

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腫瘍促進的腹膜環境の正常化を標的とした難治性卵巣癌に対する新規治療戦略の開発(Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of TGF-β1/THBS1)

北見和久, 吉原雅人, 山北由彦, 杉山麻衣, 小屋美博, 宮本絵美里, 藤本裕基, 伊吉祥平, 宇野枢, 茂木一将, 加藤一喜, 那波明宏, 榎本篤, 梶山広明

日本癌学会総会記事 Vol. 81回 page： MS1 - 3 2022.9

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糖尿病、肥満、がんとの関係を臨床・疫学・メカニズムから紐解く卵巣癌腹膜播種の形成における肥満の影響と脱分化脂肪細胞の役割(Impact of obesity and the role of dedifferentiated adipocytes upon peritoneal metastasis of ovarian cancer)

伊吉祥平, 吉原雅人, 中村香江, 角朝美, 杉山麻衣, 小屋美博, 宮本絵美里, 藤本裕基, 茂木一将, 宇野枢, 北見和久, 江本遼, 松井茂之, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 81回 page： S18 - 4 2022.9

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「卵巣癌細胞-腹膜中皮細胞複合体」による新たな腹膜播種進展メカニズムの解明

藤本裕基, 吉原雅人, 茂木一将, 宇野枢, 伊吉祥平, 北見和久, 山北由彦, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 64回 page： 278 - 278 2022.7

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コンディショナルノックインマウスを用いた卵巣がん関連中皮細胞の系譜追跡と機能解析

茂木一将, 谷口寿章, 吉原雅人, 藤本裕基, 宇野枢, 伊吉祥平, 北見和久, 杉山麻衣, 小屋美博, 山北由彦, 玉内学志, 池田芳紀, 横井暁, 芳川修久, 西野公博, 新美薫, 富田弘之, 那波明宏, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 64回 page： 194 - 194 2022.7

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若手医師によるTRをつなぐ卵巣癌腹膜播種におけるNotchシグナルを介した腫瘍内不均一性の解明と新規治療標的化

吉原雅人, 茂木一将, 藤本裕基, 伊吉祥平, 北見和久, 宇野枢, 田野翔, 玉内学志, 横井暁, 池田芳紀, 芳川修久, 西野公博, 新美薫, 那波明宏, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 64回 page： 116 - 116 2022.7

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難治性婦人科がんの克服を目指して腫瘍促進的腹膜環境の正常化を標的とした難治性卵巣癌に対する新規治療戦略の開発

北見和久, 吉原雅人, 山北由彦, 杉山麻衣, 小屋美博, 藤本裕基, 伊吉祥平, 宇野枢, 茂木一将, 玉内学志, 池田芳紀, 横井暁, 芳川修久, 西野公博, 新美薫, 那波明宏, 榎本篤, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 64回 page： 103 - 103 2022.7

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上皮性卵巣癌の転移浸潤におけるNGFR/CD271発現の臨床予後および分子生物学的役割に関する検討

小屋美博, 杉山麻衣, 吉原雅人, 北見和久, 宇野枢, 伊吉祥平, 茂木一将, 藤本裕基, 山下守, 那波明宏, 梶山広明

日本産科婦人科学会雑誌 Vol. 74 ( 臨増 ) page： S - 310 2022.2

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腹腔内コミュニケーションに注目した卵巣癌腹膜播種におけるNotchシグナルの新規機能:腫瘍内不均一性と薬剤抵抗性への関与

杉山麻衣, 吉原雅人, 小屋美博, 北見和久, 宇野枢, 伊吉祥平, 茂木一将, 藤本裕基, 山下守, 那波明宏, 梶山広明

日本産科婦人科学会雑誌 Vol. 74 ( 臨増 ) page： S - 309 2022.2

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初期粘液性卵巣癌における系統的リンパ節郭清の意義プロペンシティスコア解析

茂木一将, 吉原雅人, 玉内学志, 伊吉祥平, 横井暁, 河井通泰, 長坂徹郎, 高橋邦彦, 松井茂之, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 59回 page： O9 - 5 2021.10

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卵巣癌における腹水細胞診と治療的介入の影響大規模コホートを用いた多施設共同研究

吉原雅人, 北見和久, 茂木一将, 宇野枢, 伊吉祥平, 芳川修久, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 59回 page： O9 - 2 2021.10

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初期粘液性卵巣癌における系統的リンパ節郭清の意義プロペンシティスコア解析

茂木一将, 吉原雅人, 玉内学志, 伊吉祥平, 横井暁, 河井通泰, 長坂徹郎, 高橋邦彦, 松井茂之, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 59回 page： O9 - 5 2021.10

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NGFRは卵巣癌の悪性化に寄与している

小屋美博, 杉山麻衣, 吉原雅人, 北見和久, 宇野枢, 茂木一将, 伊吉祥平, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 80回 page： [P14 - 1] 2021.9

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ビタミンDによる卵巣癌腹膜播種を亢進する腹膜中皮細胞のEMTを標的とした治療

北見和久, 吉原雅人, 杉山麻衣, 小屋美博, 山北由彦, 伊吉祥平, 宇野枢, 茂木一将, 玉内学志, 横井暁, 芳川修久, 西野公博, 新美薫, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 80回 page： [E14 - 4] 2021.9

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ビタミンDによる卵巣癌腹膜播種を亢進する腹膜中皮細胞のEMTを標的とした治療

北見和久, 吉原雅人, 杉山麻衣, 小屋美博, 山北由彦, 伊吉祥平, 宇野枢, 茂木一将, 玉内学志, 横井暁, 芳川修久, 西野公博, 新美薫, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 80回 page： [E14 - 4] 2021.9

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卵巣癌腹膜播種においてNotchシグナルは代謝変容を通して薬剤抵抗性獲得に寄与する

杉山麻衣, 吉原雅人, 小屋美博, 北見和久, 宇野枢, 伊吉祥平, 茂木一将, 横井暁, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 80回 page： [J5 - 4] 2021.9

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卵巣癌腹膜播種巣における腫瘍内不均一性と細胞運命決定に関わるNotchシグナルの役割

吉原雅人, 杉山麻衣, 小屋美博, 伊吉祥平, 北見和久, 宇野枢, 茂木一将, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 80回 page： [E11 - 1] 2021.9

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卵巣癌腹膜播種においてNotchシグナルは代謝変容を通して薬剤抵抗性獲得に寄与する

杉山麻衣, 吉原雅人, 小屋美博, 北見和久, 宇野枢, 伊吉祥平, 茂木一将, 横井暁, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 80回 page： [J5 - 4] 2021.9

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脂肪-中皮細胞により制御される卵巣がん微小環境と腹膜播種

茂木一将, 吉原雅人, 宇野枢, 伊吉祥平, 北見和久, 杉山麻衣, 小屋美博, 玉内学志, 横井暁, 芳川修久, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 80回 page： [E10 - 4] 2021.9

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脂肪-中皮細胞により制御される卵巣がん微小環境と腹膜播種

茂木一将, 吉原雅人, 宇野枢, 伊吉祥平, 北見和久, 杉山麻衣, 小屋美博, 玉内学志, 横井暁, 芳川修久, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 80回 page： [E10 - 4] 2021.9

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9-oxo-10、12-ODAのヒト子宮頸癌細胞に対する抗腫瘍効果の解析

茂木一将, 小屋美博, 杉山麻衣, 吉原雅人, 北見和久, 伊吉祥平, 宇野枢, 田野翔, 那波明宏, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 63回 page： 215 - 215 2021.7

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I期卵巣粘液性癌における子宮温存手術の生命予後への影響

吉原雅人, 北見和久, 伊吉祥平, 宇野枢, 茂木一将, 田野翔, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 63回 page： 274 - 274 2021.7

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卵巣癌におけるプラチナ分布に基づいたプラチナ抵抗性の可視化と新規治療戦略

宇野枢, 芳川修久, 吉原雅人, 北見和久, 伊吉祥平, 大沼章子, 田崎啓, 玉内学志, 横井暁, 加藤昌志, 吉川史隆, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 63回 page： 194 - 194 2021.7

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卵巣性索間質性腫瘍I期における子宮温存手術の予後解析

茂木一将, 吉原雅人, 伊吉祥平, 宇野枢, 北見和久, 玉内学志, 池田芳紀, 横井暁, 芳川修久, 河井通泰, 長坂徹郎, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 63回 page： 274 - 274 2021.7

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I期被包性上皮卵巣癌の術中破裂に対するincomplete surgeryと術後補助化学療法の影響(Impact of Incomplete Surgery and Adjuvant Chemotherapy for the Intraoperative Rupture of Capsulated Stage I Epithelial Ovarian Cancer)

吉原雅人, 北見和久, 伊吉祥平, 宇野枢, 茂木一将, 田野翔, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 63回 page： 231 - 231 2021.7

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妊孕性温存手術を実施した早期卵巣癌患者の再発予後因子の検討

茂木一将, 宇野枢, 伊吉祥平, 北見和久, 吉原雅人, 玉内学志, 池田芳紀, 横井暁, 芳川修久, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 63回 page： 209 - 209 2021.7

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活性型ビタミンDによる中皮間葉系移行の抑制卵巣癌の腹膜播種を加速させる(Active Vitamin D Inhibits Mesothelial-mesenchymal-transition: Accelerating Peritoneal Dissemination in Ovarian Cancer)

北見和久, 吉原雅人, 杉山麻衣, 小屋美博, 伊吉祥平, 宇野枢, 茂木一将, 玉内学志, 池田芳紀, 横井暁, 芳川修久, 西野公博, 新美薫, 那波明宏, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 63回 page： 231 - 231 2021.7

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新規治療標的化を目指した癌関連腹膜中皮細胞による進行卵巣癌進展機構の解明

吉原雅人, 北見和久, 伊吉祥平, 宇野枢, 茂木一将, 田野翔, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 63回 page： 198 - 198 2021.7

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臨床的に明らかなI期原発性粘液性上皮卵巣癌に対する骨盤リンパ節および大動脈傍リンパ節郭清の予後への影響(Prognostic Impact of Pelvic and Paraaortic Lymphadenectomy on Clinically-apparent Stage I Primary Mucinous Epithelial Ovarian Carcinoma)

田野翔, 吉原雅人, 伊吉祥平, 宇野枢, 茂木一将, 北見和久, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 63回 page： 230 - 230 2021.7

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若年性卵巣明細胞癌における予後因子と妊孕性温存手術の影響に関する検討

吉原雅人, 北見和久, 伊吉祥平, 宇野枢, 茂木一将, 田野翔, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 Vol. 63回 page： 211 - 211 2021.7

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MITFは卵巣癌においてCD146を介し細胞の遊走及び浸潤に寄与している

小屋美博, 杉山麻衣, 吉原雅人, 北見和久, 宇野枢, 伊吉祥平, 山下守, 吉川史隆, 那波明宏, 梶山広明

日本産科婦人科学会雑誌 Vol. 73 ( 臨増 ) page： S - 486 2021.3

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卵巣癌腹膜播種においてNotchシグナルは腫瘍内不均一性の形成と細胞増殖亢進に寄与する

杉山麻衣, 吉原雅人, 小屋美博, 北見和久, 横井暁, 伊吉祥平, 宇野枢, 山下守, 吉川史隆, 那波明宏, 梶山広明

日本産科婦人科学会雑誌 Vol. 73 ( 臨増 ) page： S - 485 2021.3

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卵巣癌腹膜播種においてNotchシグナルは腫瘍内不均一性の形成と細胞増殖亢進に寄与する

杉山麻衣, 吉原雅人, 小屋美博, 北見和久, 横井暁, 伊吉祥平, 宇野枢, 山下守, 吉川史隆, 那波明宏, 梶山広明

日本産科婦人科学会雑誌 Vol. 73 ( 臨増 ) page： S - 485 2021.3

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I期卵巣性索間質系腫瘍における子宮温存手術の検討

宇野枢, 茂木一将, 伊吉祥平, 北見和久, 吉原雅人, 玉内学志, 芳川修久, 梶山広明

日本がん・生殖医療学会誌 Vol. 4 ( 1 ) page： 114 - 114 2021.2

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卵巣類内膜癌に対する妊孕性温存手術の腫瘍学的予後の検討

北見和久, 伊吉祥平, 茂木一将, 宇野枢, 吉原雅人, 玉内学志, 芳川修久, 梶山広明

日本がん・生殖医療学会誌 Vol. 4 ( 1 ) page： 116 - 116 2021.2

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妊孕性温存手術を実施した早期卵巣癌患者の再発予後因子の検討

茂木一将, 宇野枢, 伊吉祥平, 北見和久, 吉原雅人, 玉内学志, 芳川修久, 梶山広明

日本がん・生殖医療学会誌 Vol. 4 ( 1 ) page： 115 - 115 2021.2

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機械学習を用いたI期卵巣癌予後の検討ランダムフォレスト法による再発予測

吉原雅人, 梶山広明, 宇野枢, 北見和久, 伊吉祥平, 玉内学志, 池田芳紀, 芳川修久, 吉川史隆

日本婦人科腫瘍学会雑誌 Vol. 39 ( 1 ) page： 303 - 303 2021.1

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脱分化脂肪細胞由来間葉系細胞の卵巣癌腹膜播種微小環境における役割

伊吉祥平, 梶山広明, 吉原雅人, 北見和久, 宇野枢, 吉川史隆

日本婦人科腫瘍学会雑誌 Vol. 39 ( 1 ) page： 390 - 390 2021.1

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腫瘍内微量元素マッピングを用いたプラチナ抵抗性の可視化

宇野枢, 芳川修久, 吉原雅人, 北見和久, 伊吉祥平, 大沼章子, 田崎啓, 加藤昌志, 玉内学志, 池田芳紀, 梶山広明, 吉川史隆

日本婦人科腫瘍学会雑誌 Vol. 39 ( 1 ) page： 391 - 391 2021.1

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当院での早期子宮体癌に対する腹腔鏡下子宮悪性腫瘍手術の後方視的検討

茂木一将, 池田芳紀, 秋田寛佳, 伊吉祥平, 宇野枢, 小田結加里, 甲木聡, 服部諭美, 大野真由, 北見和久, 村上真由子, 渡邉絵里, 玉内学志, 横井暁, 芳川修久, 西野公博, 新美薫, 中村智子, 大須賀智子, 梶山広明

日本産科婦人科内視鏡学会雑誌 Vol. 36 ( Suppl.I ) page： [O - 465] 2020.11

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当院での早期子宮体癌に対する腹腔鏡下子宮悪性腫瘍手術の後方視的検討

茂木一将, 池田芳紀, 秋田寛佳, 伊吉祥平, 宇野枢, 小田結加里, 甲木聡, 服部諭美, 大野真由, 北見和久, 村上真由子, 渡邉絵里, 玉内学志, 横井暁, 芳川修久, 西野公博, 新美薫, 中村智子, 大須賀智子, 梶山広明

日本産科婦人科内視鏡学会雑誌 Vol. 36 ( Suppl.I ) page： [O - 465] 2020.11

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I期卵巣癌における術中被膜破綻と縮小手術及び術後化学療法の予後に与える影響

吉原雅人, 宇野枢, 北見和久, 伊吉祥平, 田野翔, 茂木一将, 玉内学志, 横井暁, 池田芳紀, 芳川修久, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 58回 page： O18 - 6 2020.10

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卵巣性索間質性腫瘍I期における妊孕性温存手術の後方視的解析

茂木一将, 吉原雅人, 伊吉祥平, 宇野枢, 北見和久, 玉内学志, 横井暁, 芳川修久, 池田芳紀, 河井通泰, 長坂徹郎, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 58回 page： O64 - 3 2020.10

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卵巣性索間質性腫瘍I期における妊孕性温存手術の後方視的解析

茂木一将, 吉原雅人, 伊吉祥平, 宇野枢, 北見和久, 玉内学志, 横井暁, 芳川修久, 池田芳紀, 河井通泰, 長坂徹郎, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 58回 page： O64 - 3 2020.10

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I期卵巣癌における術中被膜破綻と縮小手術及び術後化学療法の予後に与える影響

吉原雅人, 宇野枢, 北見和久, 伊吉祥平, 田野翔, 茂木一将, 玉内学志, 横井暁, 池田芳紀, 芳川修久, 梶山広明

日本癌治療学会学術集会抄録集 Vol. 58回 page： O18 - 6 2020.10

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卵巣癌の腹膜播種における腹膜中皮と脂肪組織の影響

茂木一将, 吉原雅人, 北見和久, 伊吉祥平, 宇野枢, 田野翔, 杉山麻衣, 小屋美博, 玉内学志, 横井暁, 芳川修久, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 79回 page： OE10 - 2 2020.10

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活性型ビタミンDは腹膜の中皮間葉転換を阻害し、卵巣癌腹膜播種を抑制する

北見和久, 吉原雅人, 杉山麻衣, 小屋美博, 伊吉祥平, 宇野枢, 茂木一将, 玉内学志, 横井暁, 芳川修久, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 79回 page： OE10 - 1 2020.10

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活性型ビタミンDは腹膜の中皮間葉転換を阻害し、卵巣癌腹膜播種を抑制する

北見和久, 吉原雅人, 杉山麻衣, 小屋美博, 伊吉祥平, 宇野枢, 茂木一将, 玉内学志, 横井暁, 芳川修久, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 79回 page： OE10 - 1 2020.10

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卵巣癌の腹膜播種における腹膜中皮と脂肪組織の影響

茂木一将, 吉原雅人, 北見和久, 伊吉祥平, 宇野枢, 田野翔, 杉山麻衣, 小屋美博, 玉内学志, 横井暁, 芳川修久, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 79回 page： OE10 - 2 2020.10

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腫瘍内微量元素マッピングを用いたプラチナ抵抗性の可視化

宇野枢, 芳川修久, 吉原雅人, 田崎啓, 加藤昌志, 北見和久, 伊吉祥平, 玉内学志, 杉山麻衣, 小屋美博, 梶山広明

日本癌学会総会記事 Vol. 79回 page： PE17 - 2 2020.10

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進行卵巣癌におけるNotchシグナルを介した腫瘍内細胞極性の解明と標的化

吉原雅人, 杉山麻衣, 小屋美博, 伊吉祥平, 北見和久, 宇野枢, 茂木一将, 田野翔, 玉内学志, 横井暁, 芳川修久, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 79回 page： OE11 - 2 2020.10

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進行卵巣癌におけるNotchシグナルを介した腫瘍内細胞極性の解明と標的化

吉原雅人, 杉山麻衣, 小屋美博, 伊吉祥平, 北見和久, 宇野枢, 茂木一将, 田野翔, 玉内学志, 横井暁, 芳川修久, 那波明宏, 梶山広明

日本癌学会総会記事 Vol. 79回 page： OE11 - 2 2020.10

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I期卵巣粘液性癌における子宮温存手術の生命予後への影響傾向スコア重み付け法による後方視的解析

吉原雅人, 梶山広明, 玉内学志, 北見和久, 伊吉祥平, 宇野枢, 鈴木史朗, 吉川史隆

日本がん・生殖医療学会誌 Vol. 3 ( 1 ) page： 113 - 113 2020.1

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早期上皮性卵巣癌に対する妊孕性温存術式としての卵巣腫瘍核出術の腫瘍学的予後と妊娠・生産率の検討

北見和久, 梶山広明, 玉内学志, 伊吉祥平, 宇野枢, 吉原雅人, 鈴木史朗, 吉川史隆

日本がん・生殖医療学会誌 Vol. 3 ( 1 ) page： 113 - 113 2020.1

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生殖可能年齢で発症した上皮性悪性腫瘍・境界悪性卵巣腫瘍の臨床病理学的特徴や予後に対する年齢の影響

伊吉祥平, 梶山広明, 花谷茉也, 吉原雅人, 北見和久, 宇野枢, 芳川修久, 吉川史隆

日本がん・生殖医療学会誌 Vol. 3 ( 1 ) page： 112 - 112 2020.1

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明細胞癌の生殖年齢女性における予後因子の検討

宇野枢, 梶山広明, 吉原雅人, 玉内学志, 北見和久, 伊吉祥平, 鈴木史朗, 吉川史隆

日本がん・生殖医療学会誌 Vol. 3 ( 1 ) page： 113 - 113 2020.1

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I期卵巣粘液性腫瘍における子宮温存手術の影響

宇野枢, 梶山広明, 伊吉祥平, 玉内学志, 北見和久, 吉原雅人, 鈴木史朗, 吉川史隆

日本癌治療学会学術集会抄録集 Vol. 57回 page： O3 - 1 2019.10

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サルベージ手術を施行した再発卵巣明細胞癌患者の長期腫瘍学的転帰(The long-term oncologic outcome in patients who underwent secondary salvage surgery for recurrent ovarian clear-cell carcinoma)

伊吉祥平, 梶山広明, 吉原雅人, 宇野枢, 吉田康将, 北見和久, 玉内学志, 鈴木史郎, 吉川史隆

日本癌治療学会学術集会抄録集 Vol. 57回 page： IO6 - 3 2019.10

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I期卵巣類内膜癌における傍大動脈リンパ節郭清の生命予後への影響に関する検討

吉原雅人, 梶山広明, 玉内学志, 伊吉祥平, 宇野枢, 鈴木史朗, 吉川史隆

日本癌治療学会学術集会抄録集 Vol. 57回 page： O3 - 4 2019.10

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早期上皮性卵巣癌に対する卵巣腫瘍摘出術の腫瘍学的予後と妊孕能に対する影響

北見和久, 梶山広明, 伊吉祥平, 吉田康将, 玉内学志, 吉原雅人, 宇野枢, 吉川史隆

日本癌治療学会学術集会抄録集 Vol. 57回 page： P157 - 5 2019.10

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上皮性卵巣癌におけるMITFの機能的役割(Function analysis of MITF in epithelial ovarian cancer)

北見和久, 小屋美博, 梶山広明, 杉山麻衣, 伊吉祥平, 宇野枢, 吉原雅人, 那波明宏, 吉川史隆

日本癌学会総会記事 Vol. 78回 page： P - 1061 2019.9

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卵巣癌においてCSPG4は細胞浸潤に大きく寄与している(CSPG4 highly contributes to cell invasion in ovarian carcinoma cells)

宇野枢, 小屋美博, 梶山広明, 杉山麻衣, 伊吉祥平, 北見和久, 吉原雅人, 那波明宏, 吉川史隆

日本癌学会総会記事 Vol. 78回 page： P - 2046 2019.9

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大網脂肪細胞由来線維芽細胞の卵巣癌腹膜播種微小環境における役割(The roles of omental adipocyte-derived fibroblast in tumor microenvironment at metastatic sites of ovarian cancer)

伊吉祥平, 梶山広明, 吉原雅人, 中村香江, 杉山麻衣, 小屋美博, 宇野枢, 吉川史隆

日本癌学会総会記事 Vol. 78回 page： P - 2045 2019.9

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婦人科がんの発生・病態・治療に関する最新の知見癌関連中皮細胞の卵巣癌腹膜播種進展における役割(Recent advances in generation, biology, and treatment of gynecologic cancer Carcinoma-associated mesothelial cells as a novel therapeutic target in epithelial ovarian cancer)

吉原雅人, 梶山広明, 杉山麻衣, 小屋美博, 横井暁, 伊吉祥平, 吉川史隆

日本癌学会総会記事 Vol. 78回 page： SST7 - 4 2019.9

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婦人科がんの発生・病態・治療に関する最新の知見癌関連中皮細胞の卵巣癌腹膜播種進展における役割(Recent advances in generation, biology, and treatment of gynecologic cancer Carcinoma-associated mesothelial cells as a novel therapeutic target in epithelial ovarian cancer)

吉原雅人, 梶山広明, 杉山麻衣, 小屋美博, 横井暁, 伊吉祥平, 吉川史隆

日本癌学会総会記事 Vol. 78回 page： SST7 - 4 2019.9

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pT1期卵巣類内膜癌における後腹膜リンパ節郭清の生命予後への影響傾向スコアによる後方視的解析

吉原雅人, 梶山広明, 伊吉祥平, 玉内学志, 鈴木史朗, 吉川史隆

日本婦人科腫瘍学会雑誌 Vol. 37 ( 3 ) page： 452 - 452 2019.6

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TC+Bev療法が著効したIVB期子宮頸部小細胞癌の一例

中尾優里, 玉内学志, 伊吉祥平, 吉田康将, 吉原雅人, 池田芳紀, 芳川修久, 西野公博, 新美薫, 鈴木史朗, 梶山広明, 吉川史隆

愛知産科婦人科学会学術講演会プログラム Vol. 109回 page： 13 - 13 2019.6

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若年性I期卵巣類内膜癌における生命予後因子の検討多施設間後方視的調査研究

伊吉祥平, 梶山広明, 吉原雅人, 玉内学志, 鈴木史朗, 吉川史隆

日本婦人科腫瘍学会雑誌 Vol. 37 ( 3 ) page： 531 - 531 2019.6

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19歳女性に発症した若年型顆粒膜細胞成分を含むギナンドロブラストーマの1例

伊吉祥平, 藤田和寿, 柘植志織, 柴田真由, 那須佳枝, 篠根早苗, 中村浩美, 竹田明宏

東海産科婦人科学会雑誌 Vol. 55 page： 303 - 303 2019.3

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経子宮筋層的採卵後に生じた子宮仮性動脈瘤からの遅発性出血に対して、N-butyl-2-cyanoacrylateを用いた子宮動脈塞栓術による治療が有効であった1例

藤田和寿, 伊吉祥平, 柘植志織, 柴田真由, 那須佳枝, 篠根早苗, 中村浩美, 竹田明宏, 古池亘

東海産科婦人科学会雑誌 Vol. 55 page： 290 - 290 2019.3

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単孔式腹腔鏡下手術により診断治療を行った著明な血管新生を伴う血清β-hCG陰性慢性卵管妊娠の一例

藤田和寿, 伊吉祥平, 渡邉和子, 竹田明宏

東海産婦人科内視鏡手術研究会雑誌 Vol. 6 page： 27 - 27 2018.10

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卵巣癌腹膜播種における腹膜中皮細胞による浸潤フロンティアの形成(Mesothelial cells create invasion frontier in peritoneal metastasis of epithelial ovarian cancer)

伊吉祥平, 梶山広明, 吉原雅人, 山北由彦, 杉山麻衣, 小屋美博, 劉文亭, 吉川史隆

日本癌学会総会記事 Vol. 77回 page： 355 - 355 2018.9

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In-bag morcellationを併用する腹腔鏡補助下子宮筋腫核出術における腹腔内筋腫細胞の同定

竹田明宏, 藤田和寿, 伊吉祥平, 柘植志織, 柴田真由, 篠根早苗, 中村浩美, 市橋孝章, 各務洋基

日本産科婦人科内視鏡学会雑誌 Vol. 34 ( Suppl.I ) page： 230 - 230 2018.8

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妊娠合併付属器腫瘤に対する吊り上げ法による臍部単孔式腹腔鏡下手術の治療成績の検討

藤田和寿, 伊吉祥平, 柘植志織, 柴田真由, 北見和久, 篠根早苗, 中村浩美, 竹田明宏

日本産科婦人科内視鏡学会雑誌 Vol. 34 ( Suppl.I ) page： 387 - 387 2018.8

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小児及び思春期女性の付属器腫瘤に対する吊り上げ法による臍部単孔式腹腔鏡手術の有用性に関する検討

北見和久, 竹田明宏, 藤田和寿, 伊吉祥平, 柘植志織, 柴田真由, 篠根早苗, 中村浩美

日本産科婦人科内視鏡学会雑誌 Vol. 34 ( Suppl.I ) page： 388 - 388 2018.8

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卵管角部妊娠および陥入胎盤に対し、子宮体部圧迫縫合法を応用し子宮温存し得た1例

中村浩美, 篠根早苗, 柴田真由, 柘植志織, 伊吉祥平

日本周産期・新生児医学会雑誌 Vol. 54 ( 2 ) page： 680 - 680 2018.6

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既往帝王切開妊娠の稽留流産に流産手術施行後11日目に大量性器出血にて来院した1例

柘植志織, 伊吉祥平, 柴田真由, 篠根早苗, 中村浩美

日本周産期・新生児医学会雑誌 Vol. 54 ( 2 ) page： 682 - 682 2018.6

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妊娠高血圧腎症、常位胎盤早期剥離の疑いにて母体搬送となったが、後に周産期心筋症の診断となった1例

篠根早苗, 中村浩美, 柴田真由, 柘植志織, 伊吉祥平

日本周産期・新生児医学会雑誌 Vol. 54 ( 2 ) page： 679 - 679 2018.6

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Paclitaxel、Cisplatin、Bevacizumab併用療法が著効した子宮頸癌の1例

上野琢史, 清水一紀, 中尾一貴, 安藤万恵, 伊吉祥平, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 吉原雅人, 眞山学徳, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

東海産科婦人科学会雑誌 Vol. 54 page： 312 - 312 2018.3

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卵巣子宮内膜症性嚢胞に対する薬物療法の有用性

伊吉祥平, 上野琢史, 清水一紀, 中尾一貴, 安藤万恵, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 眞山学徳, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

東海産科婦人科学会雑誌 Vol. 54 page： 307 - 307 2018.3

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妊娠高血圧症候群と正常妊婦における心機能評価

宇野枢, 上野琢史, 清水一紀, 中尾一貴, 安藤万恵, 伊吉祥平, 山田拓馬, 竹田健彦, 田野翔, 眞山学徳, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

東海産科婦人科学会雑誌 Vol. 54 page： 336 - 336 2018.3

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正常妊娠における母体Brain Natriuretic Peptide値の検討

中尾一貴, 上野琢史, 清水一紀, 安藤万恵, 伊吉祥平, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 眞山学徳, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

東海産科婦人科学会雑誌 Vol. 54 page： 329 - 329 2018.3

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悪性卵巣腫瘍に対する腹腔鏡下大網切除術の導入

安藤万恵, 中尾一貴, 上野琢史, 清水一紀, 伊吉祥平, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 眞山学徳, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

東海産科婦人科学会雑誌 Vol. 54 page： 311 - 311 2018.3

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子宮体癌の血流評価におけるSuperb Microvasclar Imagingの有用性

山田拓馬, 上野琢史, 清水一紀, 中尾一貴, 伊吉祥平, 安藤万恵, 竹田健彦, 宇野枢, 田野翔, 眞山学徳, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

東海産科婦人科学会雑誌 Vol. 54 page： 319 - 319 2018.3

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婦人科がん術後の下肢リンパ浮腫治療における予後因子

清水一紀, 上野琢史, 中尾一貴, 安藤万恵, 伊吉祥平, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 吉原雅人, 眞山学徳, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

東海産科婦人科学会雑誌 Vol. 54 page： 318 - 318 2018.3

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妊娠高血圧症候群におけるsFlt-1/PlGFの有用性

竹田健彦, 上野琢史, 清水一紀, 中尾一貴, 安藤万恵, 伊吉祥平, 山田拓馬, 宇野枢, 田野翔, 眞山学徳, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

東海産科婦人科学会雑誌 Vol. 54 page： 334 - 334 2018.3

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腹腔鏡下広汎子宮全摘出術の導入

鵜飼真由, 上野琢史, 清水一紀, 中尾一貴, 安藤万恵, 伊吉祥平, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 眞山学徳, 原田統子, 岸上靖幸, 小口秀紀

東海産科婦人科学会雑誌 Vol. 54 page： 311 - 311 2018.3

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上皮成長因子受容体チロシンキナーゼ阻害剤にて治療中の肺腺癌患者で認めた子宮転移の1例

柴田真由, 竹田明宏, 伊吉祥平, 柘植志織, 寺西佳枝, 篠根早苗, 中村浩美

日本産科婦人科学会雑誌 Vol. 70 ( 2 ) page： 774 - 774 2018.2

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流産あるいは分娩後に生じた血流豊富な癒着胎盤遺残に対する保存的血管内治療の有用性に関する検討

藤田和寿, 伊吉祥平, 柘植志織, 柴田真由, 寺西佳枝, 篠根早苗, 中村浩美, 竹田明宏

日本産科婦人科学会雑誌 Vol. 70 ( 2 ) page： 867 - 867 2018.2

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肺血栓塞栓症により発症した高度のマイクロサテライト不安定性を示す子宮内頸部漿液性癌の一例

柘植志織, 伊吉祥平, 柴田真由, 寺西佳枝, 篠根早苗, 中村浩美, 竹田明宏

日本産科婦人科学会雑誌 Vol. 70 ( 2 ) page： 661 - 661 2018.2

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上皮成長因子受容体チロシンキナーゼ阻害薬での肺腺癌治療中に子宮転移をみとめた1例

柴田真由, 竹田明宏, 伊吉祥平, 柘植志織, 那須佳枝, 篠根早苗, 中村浩美

岐阜産科婦人科学会学術集会プログラム Vol. 平成29年度 page： 7 - 7 2017.12

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流産あるいは分娩後に生じた血流豊富な癒着胎盤遺残に対する保存的血管内治療の有用性に関する検討

藤田和寿, 古池亘, 伊吉祥平, 柘植志織, 柴田真由, 寺西佳枝, 篠根早苗, 中村浩美, 竹田明宏

岐阜産科婦人科学会学術集会プログラム Vol. 平成29年度 page： 2 - 2 2017.12

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結核性腹膜炎の確定診断における腹腔鏡下手術の有用性症例報告

安藤万恵, 田野翔, 伊吉祥平, 山田拓馬, 竹田健彦, 宇野枢, 眞山学徳, 鵜飼真由, 上野琢史, 吉田英司, 吉本理沙, 鈴木徹平, 原田統子, 岸上靖幸, 小口秀紀

日本産科婦人科内視鏡学会雑誌 Vol. 33 ( 2 ) page： 288 - 292 2017.12

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44歳(2経妊1経産婦)。性交時痛を主訴に前医を受診、Douglas窩の圧痛、子宮周囲の腹水、血清CA125の上昇を指摘され、精査目的で当科へ紹介となった。内診および経腟超音波、MRI所見で多発性子宮筋腫、骨盤内に少量の腹水貯留を認めたが、両側卵巣には異常所見はなく、腹膜結節やリンパ節腫大も認められなかった。しかし、経過観察中に腹水が増加傾向となったため、胸腹部造影CTを施行したところ、大網の脂肪織濃度の上昇、多数の腹膜結節と両側胸水が確認された。経腟超音波ガイド下にDouglas窩穿刺を行ったが、腹水細胞診や細菌検査、抗酸菌染色、結核PCRは全て陰性であった。確定診断目的で腹腔鏡下手術を行い、両側卵管と腹膜結節数個を摘出し、病理組織学的検査を行ったところ、結核性腹膜炎と診断された。診断後、イソニアジド、リファンピシリン、ピラジナミド、エタンブトールの4剤併用による結核治療を開始した。その結果、治療開始2ヵ月目のCTでは胸水や腹水、腹膜結節の消失が認められた。半年にわたる抗結核療法を終了した現在、再発徴候はみられていない。

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肺血栓塞栓症により発症した高度のマイクロサテライト不安定性を示す子宮内頸部漿液性癌の1例

柘植志織, 伊吉祥平, 柴田真由, 那須佳枝, 篠根早苗, 中村浩美, 竹田明宏

岐阜産科婦人科学会学術集会プログラム Vol. 平成29年度 page： 6 - 6 2017.12

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妊娠10週未満に緊急腹腔鏡下手術を施行した子宮内妊娠13症例での妊娠予後の検討

伊吉祥平, 柘植志織, 柴田真由, 寺西佳枝, 篠根早苗, 中村浩美, 竹田明宏

東海産婦人科内視鏡手術研究会雑誌 Vol. 5 page： 25 - 25 2017.10

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慢性心不全の増悪により死亡した69歳男性・拡張型心筋症の一例

伊吉祥平, 上原侑里子, 山田拓馬, 澁谷亮, 北川諭

トヨタ医報 Vol. 27 page： 132 - 133 2017.10

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単孔式腹腔鏡下に寄生腹膜筋腫を切除した後に、門脈-下腸間膜静脈血栓症を発症した1例

伊吉祥平, 柘植志織, 柴田真由, 寺西佳枝, 井本早苗, 中村浩美, 竹田明宏

日本産科婦人科内視鏡学会雑誌 Vol. 33 ( Suppl.I ) page： 1397 - 1397 2017.8

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慢性的な経過を示す付属器捻転症例の検討

竹田明宏, 伊吉祥平, 柘植志織, 柴田真由, 寺西佳枝, 井本早苗, 中村浩美

日本産科婦人科内視鏡学会雑誌 Vol. 33 ( Suppl.I ) page： 1065 - 1065 2017.8

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Paclitaxel、Carboplatin、Bevacizumab併用療法が有用であった再発顆粒膜細胞腫の1例

中尾一貴, 清水一紀, 上野琢史, 安藤万恵, 伊吉祥平, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 眞山学徳, 鵜飼真由, 鈴木徹平, 原田統子, 岸上靖幸, 小口秀紀

日本婦人科腫瘍学会雑誌 Vol. 35 ( 3 ) page： 603 - 603 2017.6

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Peclitaxel、Carboplatin、Bevacizumab併用療法が有用であった進行子宮頸部腺癌の1例

安藤万恵, 清水一紀, 上野琢史, 中尾一貴, 伊吉祥平, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 眞山学徳, 鵜飼真由, 鈴木徹平, 原田統子, 岸上靖幸, 小口秀紀

日本婦人科腫瘍学会雑誌 Vol. 35 ( 3 ) page： 619 - 619 2017.6

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Paclitaxel、Carboplatin、Bevacizumab併用療法が著効した卵巣癌を併発した進行子宮体癌の1例

竹田健彦, 上野琢史, 中尾一貴, 安藤万恵, 伊吉祥平, 山田拓馬, 宇野枢, 田野翔, 眞山学徳, 鵜飼真由, 鈴木徹平, 原田統子, 岸上靖幸, 小口秀紀

日本婦人科腫瘍学会雑誌 Vol. 35 ( 3 ) page： 584 - 584 2017.6

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妊娠高血圧症候群における母体の左室拡張機能障害の検討

眞山学徳, 安藤万恵, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 鵜飼真由, 鈴木徹平, 伊吉祥平, 上野琢史, 岸上靖幸, 小口秀紀

日本周産期・新生児医学会雑誌 Vol. 53 ( 2 ) page： 491 - 491 2017.6

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病態生理に基づいた遺伝子組換えトロンボモデュリンαの産科DICに対する有効性の検討

田野翔, 山田拓馬, 竹田健彦, 宇野枢, 眞山学徳, 鵜飼真由, 鈴木徹平, 伊吉祥平, 安藤万恵, 上野琢史, 岸上靖幸, 小口秀紀

日本周産期・新生児医学会雑誌 Vol. 53 ( 2 ) page： 562 - 562 2017.6

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既往帝王切開後経腟分娩(TOLAC)の有効性に関する検討

宇野枢, 山田拓馬, 竹田健彦, 安藤万恵, 田野翔, 眞山学徳, 鵜飼真由, 鈴木徹平, 伊吉祥平, 上野琢史, 岸上靖幸, 小口秀紀

日本周産期・新生児医学会雑誌 Vol. 53 ( 2 ) page： 542 - 542 2017.6

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子宮頸癌に関する組織内照射の有効性の検討

宇野枢, 上野琢史, 中尾一貴, 伊吉祥平, 安藤万恵, 山田拓馬, 竹田健彦, 田野翔, 眞山学徳, 鵜飼真由, 鈴木徹平, 原田統子, 岸上靖幸, 奥田隆仁, 小口秀紀

日本婦人科腫瘍学会雑誌 Vol. 35 ( 3 ) page： 616 - 616 2017.6

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婦人科領域におけるBevacizumabの副作用についての検討

岸上靖幸, 安藤万恵, 清水一紀, 上野琢史, 中尾一貴, 伊吉祥平, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 眞山学徳, 鵜飼真由, 鈴木徹平, 原田統子, 小口秀紀

日本婦人科腫瘍学会雑誌 Vol. 35 ( 3 ) page： 564 - 564 2017.6

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妊婦における睡眠時無呼吸症候群の頻度と周産期合併症についての検討

眞山学徳, 山田拓馬, 安藤万恵, 竹田健彦, 宇野枢, 田野翔, 鵜飼真由, 鈴木徹平, 伊吉祥平, 上野琢史, 岸上靖幸, 小口秀紀

日本周産期・新生児医学会雑誌 Vol. 53 ( 2 ) page： 714 - 714 2017.6

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妊娠高血圧腎症発症におけるsFlt-1/PIGFの有用性

山田拓馬, 竹田健彦, 宇野枢, 田野翔, 眞山学徳, 鵜飼真由, 鈴木徹平, 安藤万恵, 伊吉祥平, 上野琢史, 岸上靖幸, 小口秀紀

日本周産期・新生児医学会雑誌 Vol. 53 ( 2 ) page： 614 - 614 2017.6

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症状緩和にPaclitaxel、Carboplatin、Bevacizumab併用療法が有用であった腹膜偽粘液腫の1例

上野琢史, 清水一紀, 中尾一貴, 伊吉祥平, 安藤万恵, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 眞山学徳, 鵜飼真由, 鈴木徹平, 原田統子, 岸上靖幸, 小口秀紀

日本婦人科腫瘍学会雑誌 Vol. 35 ( 3 ) page： 675 - 675 2017.6

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進行子宮頸癌におけるPaclitaxel、Cisplatin、Bevacizumab併用療法の有用性

鵜飼真由, 清水一紀, 上野琢史, 中尾一貴, 安藤万恵, 伊吉祥平, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 眞山学徳, 鈴木徹平, 原田統子, 岸上靖幸, 小口秀紀

日本婦人科腫瘍学会雑誌 Vol. 35 ( 3 ) page： 535 - 535 2017.6

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腹腔鏡下広汎子宮全摘出術の導入

山田拓馬, 上野琢史, 中尾一貴, 清水一紀, 安藤万恵, 伊吉祥平, 竹田健彦, 宇野枢, 田野翔, 眞山学徳, 鵜飼真由, 鈴木徹平, 原田統子, 岸上靖幸, 小口秀紀

日本婦人科腫瘍学会雑誌 Vol. 35 ( 3 ) page： 657 - 657 2017.6

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胎児中大脳動脈血流収縮期最高速度の妊婦健診における有用性の検討

安藤万恵, 田野翔, 山田拓馬, 竹田健彦, 宇野枢, 眞山学徳, 鵜飼真由, 鈴木徹平, 伊吉祥平, 上野琢史, 岸上靖幸, 小口秀紀

日本周産期・新生児医学会雑誌 Vol. 53 ( 2 ) page： 657 - 657 2017.6

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先天性くも膜嚢胞の診断において胎児超音波断層法が有用であった一例

安藤万恵, 伊吉祥平, 竹田健彦, 田野翔, 宇野枢, 眞山学徳, 鵜飼真由, 岸上靖幸, 小口秀紀

超音波医学 Vol. 44 ( Suppl. ) page： S576 - S576 2017.4

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周産期領域における超音波ドプラ法の意義妊婦健診における胎児中大脳動脈血流収縮期最高速度の有用性の検討

田野翔, 伊吉祥平, 山田拓馬, 竹田健彦, 宇野枢, 眞山学徳, 鵜飼真由, 岸上靖幸, 小口秀紀

超音波医学 Vol. 44 ( Suppl. ) page： S313 - S313 2017.4

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子宮頸癌におけるSuperb Microvascular Imagingの有用性の検討

宇野枢, 八重樫悠, 伊吉祥平, 竹田健彦, 田野翔, 眞山学徳, 鵜飼真由, 岸上靖幸, 小口秀紀

超音波医学 Vol. 44 ( Suppl. ) page： S563 - S563 2017.4

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DICを合併した子宮内胎児死亡を伴う常位胎盤早期剥離に対し、トロンボモデュリンαが有効であった2例

眞山学徳, 伊吉祥平, 山田拓馬, 山内佑允, 竹田健彦, 宇野枢, 田野翔, 吉原雅人, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

東海産科婦人科学会雑誌 Vol. 53 page： 368 - 368 2017.3

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婦人科癌に対する手術前後での下肢周囲径の推移とリンパ浮腫発症についての検討

藤田雄也, 伊吉祥平, 山内佑允, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 吉原雅人, 眞山学徳, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

東海産科婦人科学会雑誌 Vol. 53 page： 389 - 389 2017.3

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愛知県西三河北部医療圏における分娩施設の地域連携とその推移

山内佑允, 伊吉祥平, 山田拓馬, 竹田健彦, 宇野枢, 田野翔, 吉原雅人, 眞山学徳, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

東海産科婦人科学会雑誌 Vol. 53 page： 383 - 383 2017.3

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組織内照射を施行した局所進行子宮頸癌の4例

山田拓馬, 伊吉祥平, 山内佑允, 竹田健彦, 宇野枢, 田野翔, 吉原雅人, 眞山学徳, 鵜飼真由, 原田統子, 三輪忠人, 岸上靖幸, 奥田隆仁, 小口秀紀

東海産科婦人科学会雑誌 Vol. 53 page： 373 - 373 2017.3

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進行卵巣癌のNeoadjuvant ChemotherapyにおけるPaclitaxel、Carboplatin、Bevacizumab併用療法の有用性

伊吉祥平, 山田拓馬, 山内佑允, 竹田健彦, 宇野枢, 田野翔, 吉原雅人, 眞山学徳, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

東海産科婦人科学会雑誌 Vol. 53 page： 375 - 375 2017.3

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腹腔鏡が有用であった妊娠後期の孤立性卵管捻転の1例

近藤真哉, 宇野枢, 田野翔, 吉原雅人, 眞山学徳, 鵜飼真由, 古株哲也, 竹田健彦, 山田拓馬, 伊吉祥平, 安藤万恵, 上野琢史, 清水一紀, 中尾一貴, 原田統子, 岸上靖幸, 小口秀紀

日本産科婦人科内視鏡学会雑誌 Vol. 32 page： 214 - 219 2016.11

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33歳(1経妊1経産)。妊娠32週6日から右下腹部痛が増悪し、妊娠33週0日に切迫早産、急性虫垂炎の疑いで緊急母体搬送となった。所見では経腹超音波断層法では、右下腹部の圧痛点に一致して5.3×3.3cmの充実成分を含む嚢胞性腫瘤とその周囲に腹水を認めた。腹部MRIではT1強調像で低信号、T2強調像で高信号の4.7×3.2cmの内部に一部充実成分を伴う嚢胞性腫瘍を認めた。以上より、右卵巣腫瘍茎捻転や子宮筋腫を疑い、緊急腹腔鏡下手術を施行した。術中所見では右卵管捻転が確認され、腹腔鏡補助下に右卵管摘出術が行われた。病理組織診断は右卵管捻転による出血性壊死であった。術後は右下腹部痛の改善を認め、術後10日目に軽快退院となり、妊娠36週5日に経腟分娩にて2855gの女児を出産、母児ともに経過良好である。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2016&ichushi_jid=J02563&link_issn=&doc_id=20161227450017&doc_link_id=1390001205345902720&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390001205345902720&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif
腹腔鏡下手術が結核性腹膜炎の診断に有用であった1例結核性腹膜炎の診断と感染対策

田野翔, 宇野枢, 吉原雅人, 眞山学徳, 鵜飼真由, 竹田健彦, 山田拓馬, 伊吉祥平, 安藤万恵, 上野琢史, 清水一紀, 中尾一貴, 近藤真哉, 古株哲也, 原田統子, 岸上靖幸, 小口秀紀

日本産科婦人科内視鏡学会雑誌 Vol. 32 page： 244 - 249 2016.11

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79歳(3経妊3経産)。腹部膨満と食思不振を主訴に前医を受診し、腹水貯留を指摘され紹介となった。初診時、多量の腹水貯留とCA125が高値を示し、癌性腹膜炎と結核性腹膜炎の鑑別が困難であったため、感染対策としてN95マスクを使用して腹腔鏡下手術を行った。腹腔鏡所見では腹膜、横隔膜下、子宮、両側付属器、腸管等に広範に散在する約2mm程度の白色粟状結節を多数認めた。診断目的に右付属器摘出術と前腹壁の小結節を切除した結果、結核性腹膜炎の診断に至った。診断後はイソニアジド、リファンピシン、ピラジナミドの3剤併用による結核治療を開始した。治療開始50日後の腹部CTでは腹水が消失し、治療終了から6ヵ月経過した時点で結核性腹膜炎の再発徴候はなく、現在は外来観察中である。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2016&ichushi_jid=J02563&link_issn=&doc_id=20161227450023&doc_link_id=1390282680322624384&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390282680322624384&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif
子宮を診る-超音波検査の可能性と限界- 子宮体癌におけるSuperb Microvasclar Imagingの有用性

鵜飼真由, 竹田健彦, 広田真一, 伊吉祥平, 田野翔, 宇野枢, 吉原雅人, 眞山学徳, 岸上靖幸, 小口秀紀

超音波医学 Vol. 43 ( Suppl. ) page： S385 - S385 2016.4

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子宮頸部小細胞癌治療におけるSuperb Microvasclar Imaging像の変化

伊吉祥平, 鵜飼真由, 竹田健彦, 広田真一, 田野翔, 宇野枢, 吉原雅人, 眞山学徳, 岸上靖幸, 小口秀紀

超音波医学 Vol. 43 ( Suppl. ) page： S710 - S710 2016.4

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トロンボモジュリンアルファが治療に有効であった、子宮内胎児死亡を伴う常位胎盤早期剥離に起因するDICを合併した2例

伊吉祥平, 竹田健彦, 宇野枢, 田野翔, 吉原雅人, 眞山学徳, 鵜飼真由, 山内佑允, 原田統子, 岸上靖幸, 小口秀紀

日本産科婦人科学会雑誌 Vol. 68 ( 2 ) page： 725 - 725 2016.2

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妊娠中に発症し産後に偽性Gitelman症候群と診断した1例

山内佑允, 竹田健彦, 田野翔, 宇野枢, 吉原雅人, 眞山学徳, 鵜飼真由, 伊吉祥平, 原田統子, 岸上靖幸, 小口秀紀

日本産科婦人科学会雑誌 Vol. 68 ( 2 ) page： 941 - 941 2016.2

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子宮筋層内に胎児成分が遺残した子宮穿孔に対し修復術を施行し、術後に経腟分娩で生児を得た1例

田野翔, 伊吉祥平, 山内佑允, 竹田健彦, 宇野枢, 吉原雅人, 眞山学徳, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

日本産科婦人科学会雑誌 Vol. 68 ( 2 ) page： 938 - 938 2016.2

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婦人科がん治療に関連した下肢リンパ浮腫における治療予後因子の検討

吉原雅人, 田野翔, 宇野枢, 眞山学徳, 鵜飼真由, 山内佑允, 伊吉祥平, 竹田健彦, 原田統子, 岸上靖幸, 小口秀紀

日本産科婦人科学会雑誌 Vol. 68 ( 2 ) page： 863 - 863 2016.2

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転移性婦人科癌に対するサイバーナイフの有用性についての検討

竹田健彦, 伊吉祥平, 山内佑允, 田野翔, 宇野枢, 吉原雅人, 眞山学徳, 鵜飼真由, 原田統子, 岸上靖幸, 小口秀紀

日本産科婦人科学会雑誌 Vol. 68 ( 2 ) page： 883 - 883 2016.2

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進行性卵巣癌におけるPaclitaxel、Carboplatin、Bevacizumab併用療法の有用性

鵜飼真由, 伊吉祥平, 山内佑允, 竹田健彦, 宇野枢, 田野翔, 吉原雅人, 眞山学徳, 原田統子, 岸上靖幸, 小口秀紀

日本産科婦人科学会雑誌 Vol. 68 ( 2 ) page： 663 - 663 2016.2

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Superb Microvasclar Imaging(SMI)が微細な血流を捉えるのに有用であったKrukenberg腫瘍の1例

鵜飼真由, 山内佑允, 伊吉祥平, 竹田武彦, 宇野枢, 田野翔, 吉原雅人, 眞山学徳, 岸上靖幸, 小口秀紀

超音波医学 Vol. 42 ( 6 ) page： 746 - 746 2015.11

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経腟超音波ガイド下針生検で診断した子宮肉腫の1例

山内佑允, 伊吉祥平, 竹田武彦, 宇野枢, 田野翔, 吉原雅人, 眞山学徳, 鵜飼真由, 岸上靖幸, 小口秀紀

超音波医学 Vol. 42 ( 6 ) page： 747 - 747 2015.11

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超音波断層法で診断した水頭症を合併したbody stalk anomalyの1例

伊吉祥平, 山内佑允, 竹田武彦, 宇野枢, 田野翔, 吉原雅人, 眞山学徳, 鵜飼真由, 岸上靖幸, 小口秀紀

超音波医学 Vol. 42 ( 6 ) page： 747 - 747 2015.11

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超音波ガイド下に穿刺したカテーテルによる持続ドレナージが有効であった術後リンパ嚢胞の一例

竹田健彦, 山内佑允, 伊吉祥平, 宇野枢, 田野翔, 吉原雅人, 眞山学徳, 鵜飼真由, 岸上靖幸, 小口秀紀

超音波医学 Vol. 42 ( 6 ) page： 747 - 747 2015.11

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Presentations 58

I期上皮性卵巣癌患者の再発後生存に対する妊孕性温存術の影響

吉原雅人, 茂木一将, 宮本絵美里, 伊吉祥平, 宇野枢, 藤本裕基, 芳川修久, 梶山広明

東海産科婦人科学会雑誌 2025

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Event date： 2025

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子宮頸がんに対する同時化学放射線療法にて寛解約20年後に外陰部Bowen病と膣がんを発症した1例

大川明日香, 清水裕介, 嶋谷拓真, 菱川里沙, 宮本絵美里, 窪川芽衣, 國島温志, 安井裕子, 田中秀明, 伊吉祥平, 吉田康将, 吉原雅人, 玉内学志, 横井暁, 池田芳紀, 芳川修久, 新美薫, 梶山広明

東海産科婦人科学会雑誌 2025

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妊娠部位の確認に子宮鏡が有用であった頸管妊娠流産後HCG再上昇を認めた2症例

伊吉祥平, 太田肇, 小林裕太, 足立健敏, 安井裕子, 竹田健彦, 三宅菜月, 曽根原玲菜, 村岡彩子, 中村智子, 大須賀智子, 梶山広明

東海産科婦人科学会雑誌 2025

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Retained products of conception(RPOC)の致死的出血予測:多施設共同研究からの知見

中村智子, 可世木聡, 曽根原玲菜, 西田一貴, クレティアンバジル, 北原慈和, 白崎茉莉, 古井憲作, 上田真子, 河井啓一郎, 竹田健彦, 関友望, 伊吉祥平, 三宅菜月, 村岡彩子, 大須賀智子, 後藤真紀, 岩瀬明, 梶山広明

日本生殖医学会雑誌 2025

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不妊外来における尿蛋白定量検査の必要性

河井啓一郎, 曽根原玲菜, 上田真子, 竹田健彦, 可世木聡, 関友望, 伊吉祥平, 三宅菜月, 村岡彩子, 中村智子, 大須賀智子, 梶山弘明

愛知産科婦人科学会学術講演会プログラム 2024.10 愛知産科婦人科学会

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血清LDH値を子宮体癌患者のバイオマーカーに利用する可能性についての検討

窪川芽衣, 芳川修久, 松川哲也, 服部諭美, 伊吉祥平, 吉田康将, 茂木一将, 吉原雅人, 玉内学志, 横井暁, 新美薫, 梶山広明

日本癌治療学会学術集会抄録集 2024.10 (一社)日本癌治療学会

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難治性卵巣癌腹膜播種を克服する中皮細胞標的治療の開発(Development of mesothelial cell-targeted therapy to overcome peritoneal dissemination of refractory ovarian cancer)

吉原雅人, 宮本絵美里, 茂木一将, 藤本裕基, 伊吉祥平, 宇野枢, 國島温志, 小屋美博, 北見和久, 梶山広明

日本癌学会総会記事 2024.9 (一社)日本癌学会

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腫瘍関連線維症(TAF)による卵巣癌の進行を促進する新規メカニズムの解明(Elucidation of a novel mechanism of ovarian cancer progression with tumor-associated fibrosis(TAF))

藤本裕基, 吉原雅人, 小屋美博, 宮本絵美里, 茂木一将, 宇野枢, 伊吉祥平, 北見和久, 那波明宏, 梶山広明, 小屋美博

日本癌学会総会記事 2024.9 (一社)日本癌学会

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脂肪細胞を標的とした卵巣癌大網転移の新規治療戦略(Targeting adipocytes at tumor microenvironment of ovarian cancer omental metastasis)

伊吉祥平, 多喜正泰, 有賀隆世, 佐藤綾人, 吉原雅人, 小屋美博, 宮本絵美里, 藤本裕基, 國島温志, 宇野枢, 茂木一将, 北見和久, 梶山広明, 梶山広明

日本癌学会総会記事 2024.9 (一社)日本癌学会

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卵巣癌の腹膜播種抑制におけるビタミンD誘導体の役割(Exploring the role of vitamin D derivatives in inhibiting peritoneal dissemination of ovarian cancer)

林舞阿, 吉原雅人, 伊吉祥平, 茂木一将, 宮本絵美里, 藤本裕基, 宇野枢, 北見和久, 野村怜史, 小屋美博, 早川紗生, 梶山広明

日本癌学会総会記事 2024.9 (一社)日本癌学会

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AIを用いた卵巣腫瘍の早期診断システムの開発(Development of an early diagnosis system for ovarian tumors using Artificial Intelligence)

國島温志, 池田芳紀, 稲葉大樹, 小泉憲裕, 後藤万由子, 松村令糸生, 橋本瑞樹, 伊吉祥平, 吉田康将, 茂木一将, 吉原雅人, 玉内学志, 横井暁, 芳川修久, 新美薫, 梶山広明, 池田芳紀

日本癌学会総会記事 2024.9 (一社)日本癌学会

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9-oxo-10,12-ODAsのヒト子宮頸癌細胞に対する抗腫瘍効果の検討(9-oxo-10,12-octadecadienoic acid suppresses the proliferation of human cervical cancer cells)

茂木一将, 小屋美博, 吉原雅人, 國島温志, 宮本絵美里, 藤本裕基, 伊吉祥平, 宇野枢, 北見和久, 玉内学志, 横井暁, 新美薫, 富田弘之, 那波明宏, 梶山広明, 吉原雅人, 國島温志

日本癌学会総会記事 2024.9 (一社)日本癌学会

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進行卵巣癌でMeflin陽性癌関連線維芽細胞が腫瘍進展、生命予後に与える影響(Meflin-positive cancer-associated fibroblasts exhibit anti-tumor effects in advanced ovarian cancer)

宮本絵美里, 吉原雅人, 小屋美博, 藤本裕基, 伊吉祥平, 茂木一将, 宇野枢, 北見和久, 榎本篤, 梶山広明, 梶山広明

日本癌学会総会記事 2024.9 (一社)日本癌学会

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難治性卵巣癌の微小環境が誘導する抗癌剤ホルミシスとその克服へ向けて(Toward Overcoming Chemotherapy Hormesis Induced by the Microenvironment of Refractory Ovarian Cancer)

玉内学志, 吉田康将, 茂木一将, 伊吉祥平, 吉原雅人, 横井暁, 梶山広明

日本癌学会総会記事 2024.9 (一社)日本癌学会

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進行卵巣癌における腹膜播種治療抵抗性を促進する腹水中転移小体の機能解明(Metastatic units in ascites drive peritoneal dissemination and therapeutic resistance in advanced ovarian cancer)

早川紗生, 吉原雅人, 伊吉祥平, 茂木一将, 宮本絵美里, 藤本裕基, 宇野枢, 北見和久, 野村怜史, 小屋美博, 林舞阿, 梶山広明

日本癌学会総会記事 2024.9 (一社)日本癌学会

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I期上皮性卵巣癌患者に対する妊孕性温存術の再発後生存への影響後方視的多施設共同研究

吉原雅人, 宮本絵美里, 伊吉祥平, 茂木一将, 宇野枢, 藤本裕基, 北見和久, 吉田康将, 玉内学志, 横井暁, 芳川修久, 新美薫, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 2024.7 (公社)日本婦人科腫瘍学会

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当院における外陰部扁平上皮癌の治療成績と予後の検討

國島温志, 池田芳紀, 伊吉祥平, 吉田康将, 吉原雅人, 玉内学志, 清水裕介, 横井暁, 芳川修久, 新美薫, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 2024.7 (公社)日本婦人科腫瘍学会

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実臨床向き新概念「抗癌剤の貢献期間」による再発漿液性卵巣癌に対する抗癌剤の有効性の評価

前田修, 本岡大社, 伊藤真文, 宮本絵美里, 伊吉祥平, 吉原雅人, 池田芳紀, 芳川修久, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 2024.7 (公社)日本婦人科腫瘍学会

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婦人科がんtranslational researchのnext innovation 卵巣癌腹水の大規模プロテオミクス解析による分子型サブグループと予後マーカーの探索

伊吉祥平, ドレイヤー・トビアス, 吉原雅人, 山北由彦, 宮本絵美里, 藤本裕基, 茂木一将, 北見和久, 宇野枢, 吉田康将, 玉内学志, 横井暁, 芳川修久, 新美薫, マグドレン・ビクター, シリング・オリバー, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集 2024.7 (公社)日本婦人科腫瘍学会

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腹腔鏡下予防的性腺切除術により診断された卵巣未分化胚細胞腫を伴うXY純粋型性腺形成不全症の1例

伊吉祥平, 大須賀智子, 畠山未来, 菱川里沙, 河井啓一郎, 窪川芽衣, 加藤彬人, 宮本絵美里, 竹田健彦, 安井裕子, 可世木聡, 関友望, 三宅菜月, 曽根原玲菜, 村岡彩子, 中村智子, 梶山広明

愛知産科婦人科学会学術講演会プログラム 2024.7 愛知産科婦人科学会

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メフリン陽性癌関連線維芽細胞は腹膜播種抑制制御を介して進行卵巣癌に抗腫瘍効果を示す(Oncology-Basic Research 2 Meflin-positive cancer-associated fibroblasts exhibit antitumor effect in advanced ovarian cancer through regulation of inhibition of peritoneal dissemination)

Miyamoto Emiri, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Fujimoto Hiroki, Iyoshi Shohei, Mogi Kazumasa, Uno Kaname, Kitami Kazuhisa, Kajiyama Hiroaki

日本産科婦人科学会雑誌 2024.2 (公社)日本産科婦人科学会

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腫瘍内血管の供給源としてのがん関連中皮細胞は卵巣がんの潜在的治療標的である(Cancer-associated mesothelial cells as a source of intratumoral vessels are potential therapeutic targets for ovarian cancer)

Mogi Kazumasa, Yoshihara Masato, Miyamoto Emiri, Fujimoto Hiroki, Uno Kaname, Iyoshi Shohei, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 2024.2 (公社)日本産科婦人科学会

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白金製剤の分布による白金製剤耐性卵巣癌の新たな定義(New definition of platinum resistant ovarian cancer through platinum distribution)

Uno Kaname, Yoshihara Masato, Yamakita Yoshihiko, Miyamoto Emiri, Fujimoto Hiroki, Iyoshi Shohei, Mogi Kazumasa, Sugiyama Mai, Koya Yoshihiro, Yoshikawa Nobuhisa, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 2024.2 (公社)日本産科婦人科学会

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卵巣癌腹膜転移における脂肪組織の標的脂肪細胞脱分化の腫瘍促進的役割と悪性腹水による脱分化過程阻害剤スクリーニングのための新規脂質滴蛍光センサーの開発(Targeting adipose tissue in ovarian cancer peritoneal metastasis; A tumor promoting role of adipocyte dedifferentiation and the development of a novel lipid droplet fluorescent sensor for inhibitor screening of dedifferentiation process caused by malignant ascites)

Iyoshi Shohei, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Kitami Kazuhisa, Miyamoto Emiri, Fujimoto Hiroki, Uno Kaname, Mogi Kazumasa, Kajiyama Hiroaki

日本産科婦人科学会雑誌 2024.2 (公社)日本産科婦人科学会

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難治性卵巣癌の腹膜進展に対する潜在的治療標的としての癌関連線維症(Cancer-associated fibrosis as a potential therapeutic target for peritoneal progression of refractory ovarian cancer)

Yoshihara Masato, Fujimoto Hiroki, Iyoshi Shohei, Miyamoto Emiri, Mogi Kazumasa, Uno Kaname, Kitami Kazuhisa, Sugiyama Mai, Koya Yoshihiro, Nawa Akihiro, Kajiyama Hiroaki

日本産科婦人科学会雑誌 2024.2 (公社)日本産科婦人科学会

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子宮温存手術がI期卵巣性索間質性腫瘍の予後に与える影響

伊吉祥平, 吉原雅人, 宮本絵美里, 茂木一将, 藤本裕基, 宇野枢, 北見和久, 芳川修久, 梶山広明

日本がん・生殖医療学会誌 2024.1 (一社)日本がん・生殖医療学会

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生殖可能年齢における卵巣癌化学療法の変遷と維持療法の影響

宮本絵美里, 吉原雅人, 伊吉祥平, 茂木一将, 藤本裕基, 宇野枢, 北見和久, 芳川修久, 梶山広明

日本がん・生殖医療学会誌 2024.1 (一社)日本がん・生殖医療学会

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9-oxo-10,12-octadecadienoic acid suppresses the proliferation of human cervical cancer cells

茂木一将, 小屋美博, 吉原雅人, 國島温志, 宮本絵美里, 藤本裕基, 伊吉祥平, 宇野枢, 北見和久, 玉内学志, 横井暁, 新美薫, 富田弘之, 那波明宏, 梶山広明

日本癌学会学術総会抄録集(Web) 2024

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Elucidation of a novel mechanism of ovarian cancer progression with tumor-associated fibrosis (TAF)

藤本裕基, 藤本裕基, 吉原雅人, 小屋美博, 宮本絵美里, 茂木一将, 宇野枢, 宇野枢, 伊吉祥平, 伊吉祥平, 北見和久, 那波明宏, 梶山広明

日本癌学会学術総会抄録集(Web) 2024

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Targeting adipocytes at tumor microenvironment of ovarian cancer omental metastasis

伊吉祥平, 伊吉祥平, 多喜正泰, 有賀隆世, 佐藤綾人, 吉原雅人, 小屋美博, 宮本絵美里, 藤本裕基, 國島温志, 宇野枢, 茂木一将, 北見和久, 梶山広明

日本癌学会学術総会抄録集(Web) 2024

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索状性腺に未分化胚細胞腫を認めたXY純粋型性腺形成不全症

竹田健彦, 伊吉祥平, 大須賀智子, 阮加里, 上田真子, 河井啓一郎, 関友望, 可世木聡, 曽根原玲菜, 三宅菜月, 村岡彩子, 中村智子, 梶山広明

臨床内分泌代謝Update抄録集(Web) 2024

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生殖医療の最新潮流とその一歩先最新潮流:卵巣予備能から着床まで【配偶子と授精・胚発育】高感度AMH測定

大須賀智子, 伊吉祥平, 伊吉祥平

臨床婦人科産科 2024

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完全腫瘍切除された上皮性卵巣癌患者での組織型別腫瘍学的転帰の検討

茂木一将, 吉原雅人, 宮本絵美里, 藤本裕基, 藤本裕基, 宇野枢, 宇野枢, 田野翔, 伊吉祥平, 北見和久, 芳川修久, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web) 2024

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女性ホルモン関連製剤投与での留意点

中村智子, 上田真子, 河井啓一郎, 竹田健彦, 可世木聡, 関友望, 伊吉祥平, 曽根原玲菜, 三宅菜月, 村岡彩子, 大須賀智子, 梶山広明

臨床内分泌代謝Update抄録集(Web) 2024

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卵巣癌腹膜播種における好中球組織内浸潤が生命予後へ及ぼす影響

宮本絵美里, 吉原雅人, 藤本裕基, 伊吉祥平, 茂木一将, 北見和久, 宇野枢, 梶山広明

日本癌治療学会学術集会(Web) 2024

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卵巣癌腹水の大規模プロテオミクス解析による分子型サブグループと予後マーカーの探索

伊吉祥平, 伊吉祥平, ドレイヤートビアス, 吉原雅人, 山北由彦, 宮本絵美里, 藤本裕基, 茂木一将, 北見和久, 宇野枢, 吉田康将, 玉内学志, 横井暁, 芳川修久, 新美薫, マグドレンビクター, シリングオリバー, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web) 2024

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卵巣癌化学療法の変遷と維持療法の影響

茂木一将, 茂木一将, 吉原雅人, 宮本絵美里, 藤本裕基, 國島温志, 伊吉祥平, 吉田康将, 玉内学志, 横井暁, 芳川修久, 新美薫, 梶山広明

日本癌治療学会学術集会(Web) 2024

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Exploring the role of vitamin D derivatives in inhibiting peritoneal dissemination of ovarian cancer

林舞阿, 吉原雅人, 伊吉祥平, 茂木一将, 宮本絵美里, 藤本裕基, 宇野枢, 北見和久, 野村怜史, 小屋美博, 早川紗生, 梶山広明

日本癌学会学術総会抄録集(Web) 2024

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マウス卵巣癌高播種株の確立と腹膜播種性向に与えるADAM/MMP分子群の役割

國島温志, 伊吉祥平, 伊吉祥平, 宮本絵美里, 藤本裕基, 宇野枢, 北見和久, 北見和久, 茂木一将, 吉原雅人, 山北由彦, 小屋美博, 小屋美博, 梶山広明

日本病態プロテアーゼ学会学術集会プログラム抄録集 2024

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プロテオーム解析による絨毛癌特異的分子プロファイルの同定

安井裕子, 新美薫, 伊吉祥平, 吉田康将, 西子裕規, 柴田真由, 西野公博, 山本英子, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web) 2024

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「癌関連線維化(tumor-associated fibrosis;TAF)」による新たな腹膜播種進展メカニズムの解明

藤本裕基, 藤本裕基, 吉原雅人, 宮本絵美里, 伊吉祥平, 宇野枢, 茂木一将, 北見和久, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web) 2024

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I期上皮性卵巣癌患者に対する妊孕性温存術の再発後生存への影響:後方視的多施設共同研究

吉原雅人, 宮本絵美里, 伊吉祥平, 茂木一将, 宇野枢, 藤本裕基, 北見和久, 北見和久, 吉田康将, 玉内学志, 横井暁, 芳川修久, 新美薫, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web) 2024

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Development of an early diagnosis system for ovarian tumors using Artificial Intelligence

國島温志, 池田芳紀, 池田芳紀, 稲葉大樹, 小泉憲裕, 後藤万由子, 村松令糸生, 橋本瑞樹, 伊吉祥平, 吉田康将, 茂木一将, 吉原雅人, 玉内学志, 横井暁, 芳川修久, 新美薫, 梶山広明

日本癌学会学術総会抄録集(Web) 2024

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進行卵巣癌でMeflin陽性癌関連線維芽細胞が腫瘍進展,生命予後に与える影響

宮本絵美里, 吉原雅人, 藤本裕基, 伊吉祥平, 茂木一将, 宇野枢, 北見和久, 梶山広明

日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web) 2024

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Development of mesothelial cell-targeted therapy to overcome peritoneal dissemination of refractory ovarian cancer

吉原雅人, 宮本絵美里, 茂木一将, 藤本裕基, 伊吉祥平, 宇野枢, 國島温志, 小屋美博, 北見和久, 梶山広明

日本癌学会学術総会抄録集(Web) 2024

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Toward Overcoming Chemotherapy Hormesis Induced by the Microenvironment of Refractory Ovarian Cancer

玉内学志, 吉田康将, 茂木一将, 伊吉祥平, 吉原雅人, 横井暁, 梶山広明

日本癌学会学術総会抄録集(Web) 2024

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Metastatic units in ascites drive peritoneal dissemination and therapeutic resistance in advanced ovarian cancer

早川紗生, 吉原雅人, 伊吉祥平, 茂木一将, 宮本絵美里, 藤本裕基, 宇野枢, 北見和久, 野村怜史, 小屋美博, 林舞阿, 梶山広明

日本癌学会学術総会抄録集(Web) 2024

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Meflin-positive cancer-associated fibroblasts exhibit anti-tumor effects in advanced ovarian cancer.

宮本絵美里, 吉原雅人, 小屋美博, 藤本裕基, 伊吉祥平, 茂木一将, 宇野枢, 北見和久, 榎本篤, 梶山広明

日本癌学会学術総会抄録集(Web) 2024

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卵巣癌悪性腹水の大規模プロテオミクス解析による分子型サブタイプのプロファイリングと予後マーカーの探索

伊吉祥平, 伊吉祥平, 伊吉祥平, トビアスドレイヤー, 吉原雅人, 梶山広明, ビクターマグドレン, オリバーシリング

日本病態プロテアーゼ学会学術集会プログラム抄録集 2022

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還元型フルオレセイン骨格を有する新規レシオ型銅一価蛍光プローブの開発

伊吉祥平, 多喜正泰, 山本行男

日本化学会講演予稿集 2011

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CS124骨格を有する時間分解型亜鉛蛍光プローブの開発

山元雅信, 伊吉祥平, 多喜正泰, 山本行男

日本化学会講演予稿集 2011

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チオエーテル配位子を有する銅一価錯体の構造及び物理化学的性質

吉田兆志, 伊吉祥平, 多喜正泰, 山本行男

日本化学会講演予稿集 2011

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Controlling Redox Behavior of Copper(I) by Multidentate Thioether Ligands and its Effect on the Luminescence Properties of the Conjugated Fluorophore

伊吉祥平, 多喜正泰, 山本行男

日本化学会講演予稿集 2009

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各種チオエーテル系配位子を含む銅一価蛍光プローブの開発

伊吉祥平, 多喜正泰, 山本行男

錯体化学討論会講演要旨集 2009

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チオエーテル含有多座配位子を用いた銀および銅(I)錯体の構造と発光特性

伊吉祥平, 多喜正泰, 山本行男

錯体化学討論会講演要旨集 2008

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チオエーテル配位子を有するロサミン型蛍光センサーの構造と機能

伊吉祥平, 多喜正泰, 山本行男

日本化学会講演予稿集 2008

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チオエーテル配位子を有するロサミン型蛍光プローブの開発と金属イオンに対する蛍光挙動

伊吉祥平, 多喜正泰, 山本行男

錯体化学討論会講演要旨集 2007

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トロポニンの蛍光一分子計測を目指した種々の二官能基性蛍光ラベル剤の開発

平山祐, 伊吉祥平, 多喜正泰, 山本行男

日本化学会講演予稿集 2007

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Event date： 2007

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To the head of Presentations.▲

KAKENHI (Grants-in-Aid for Scientific Research) 4

Development of single-cell lipid metabolism assay system for the precise prognostic prediction of advanced ovarian cancer

Grant number：24K19723 2024.4 - 2027.3

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists

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Authorship：Principal investigator

Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

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Interdisciplinary research toward the feto-maternal interface environmental strategies with targeted proteomics

Grant number：23KK0157 2023.9 - 2027.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (International Collaborative Research)

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Authorship：Coinvestigator(s)

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Development of Novel Therapeutic Strategies for Advanced Ovarian Cancer Based on Clinical Proteomics and Chemical Biology

Grant number：23K19653 2023.8 - 2025.3

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up

Iyoshi Shohei

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Authorship：Principal investigator

Grant amount：\2860000 （ Direct Cost: \2200000 、 Indirect Cost：\660000 ）

To overcome the treatment resistance of advanced ovarian cancer with peritoneal dissemination, it is essential to develop novel therapeutic strategies that target not only cancer cells but also the tumor-promoting peritoneal microenvironment, including adipose tissue and malignant ascites. In this study, we developed a novel photostable lipid droplet fluorescent probe and established a screening assay to identify inhibitors of adipocyte dedifferentiation. Preliminary chemical library screening revealed that candidate compounds suppressed cancer cell proliferation via inhibition of adipocyte dedifferentiation. Additionally, proteomic analysis of ascitic fluid from 91 patients revealed three molecular subgroups and prognostic biomarker candidates. Functional assays using recombinant proteins demonstrated their inhibitory effects on cancer cell adhesion and proliferation. These findings support a new therapeutic approach targeting the peritoneal ecosystem.

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局所的金属イオン濃度変化の検出を目指したタンパク質結合性蛍光プローブの開発

Grant number：09J02346 2009 - 2011

日本学術振興会科学研究費助成事業特別研究員奨励費

伊吉祥平

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本年度は、細胞膜局在型亜鉛蛍光プローブの開発及びレシオ型銅一価蛍光プローブの開発を行った。前者では、まずテトラメチルロサミン(TMR)骨格に亜鉛配位部位を結合させたモデル化合物LTMRを合成し、生理的条件下において種々の測定を行ったところ、亜鉛イオンの添加に伴って90倍程度の蛍光増大が観測された。また、この蛍光応答性は亜鉛特異的であったことから、LTMRは亜鉛蛍光プローブとして十分な機能を有していることがわかった。次に、LTMRのメチル基を長鎖アルキル基ジオクタデシルアミン(DODA)で置換したLR-DODAを新規に合成した。亜鉛イオンに対する蛍光応答について検討したところ、LTMRで得られた結果と同様、強い蛍光増大が確認された。DODAは細胞膜に固定化されるが、亜鉛結合部位は膜非透過性であることから、LR-DODAは細胞膜外側における局所的な亜鉛濃度変化をイメージングできるツール分子として機能することが期待できる。後者では、前年度報告したベンジルエーテルを介して還元型フルオレセインに三座配位子TPAを結合させた化合物(FluTPAs)のFRET機構に基づいたレシオ型プローブへの拡張を目指し、FluTPA骨格へのエネルギードナーとしてのクマリン誘導体の導入を試みた。ピペラジンあるいはシクロヘキサンをリンカーとする化合物CC-FluTPA2およびCP-FluTPA2をそれぞれ合成し、銅一価イオンに対する蛍光応答能や金属イオン選択性などから、レシオ型蛍光プローブ分子としての機能を総合的に評価した。2mMアスコルビン酸ナトリウム存在下において、1μM CC-FluTPA2メタノール溶液の蛍光スペクトル測定を行ったところ、465nm付近にクマリン部位由来の蛍光が観測された。また、この溶液に5当量の銅一価イオンを添加したところ、465nmの蛍光の減少とともに、フルオレセイン部位由来と考えられる510nmの蛍光の増大が確認された。加えてCC-FluTPA2は銅一価イオンに対して選択的な蛍光応答を示す事が確認され、銅一価蛍光プローブとして十分な機能を有していることが示唆された。

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To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲