Updated on 2024/04/11


IKAWA Keisuke
Graduate School of Science Assistant Professor
Graduate School
Graduate School of Science
Undergraduate School
School of Science Department of Biological Science
Assistant Professor
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Degree 1

  1. 博士 (生命科学) ( 2014.3   京都大学 ) 

Research Interests 5

  1. Morphogenesis

  2. Cell competition

  3. cell adhesion

  4. morphogenesis

  5. actin cytoskeleton

Research Areas 4

  1. Life Science / Cell biology  / シグナル伝達

  2. Life Science / Cell biology  / アクチン細胞骨格

  3. Life Science / Cell biology

  4. Life Science / Developmental biology

Current Research Project and SDGs 2

  1. 上皮組織からの細胞離脱の分子メカニズムの解明

  2. 細胞競合過程における新規分子メカニズムの解明

Research History 4

  1. 名古屋大学大学院理学研究科生命理学専攻


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  2. The University of Tokyo   Designated assistant professor

    2021.7 - 2022.4

  3. The University of Tokyo   Researcher

    2021.4 - 2021.6

  4. Kyoto University   Researcher

    2014.4 - 2021.3

Education 2

  1. Kyoto University

    2011.4 - 2014.3

  2. Kyoto University

    2009.4 - 2011.3

Professional Memberships 4

  1. 細胞生物学会


  2. 分子生物学会



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Awards 1

  1. 若手優秀発表賞

    2017.6   細胞生物学会  

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    Award type:Award from Japanese society, conference, symposium, etc. 


Papers 7

  1. Mechanical convergence in mixed populations of mammalian epithelial cells.

    Gauquelin E, Kuromiya K, Namba T, Ikawa K, Fujita Y, Ishihara S, Sugimura K

    The European physical journal. E, Soft matter   Vol. 47 ( 3 ) page: 21   2024.3

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    DOI: 10.1140/epje/s10189-024-00415-w


  2. Coronin-1 promotes directional cell rearrangement in <i>Drosophila</i> wing epithelium

    Ikawa Keisuke, Hiro Souta, Kondo Shu, Ohsawa Shizue, Sugimura Kaoru

    Cell Structure and Function   Vol. 48 ( 2 ) page: 251 - 257   2023

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Society for Cell Biology  

    <p>Directional cell rearrangement is a critical process underlying correct tissue deformation during morphogenesis. Although the involvement of F-actin regulation in cell rearrangement has been established, the role and regulation of actin binding proteins (ABPs) in this process are not well understood. In this study, we investigated the function of Coronin-1, a WD-repeat actin-binding protein, in controlling directional cell rearrangement in the <i>Drosophila</i> pupal wing. Transgenic flies expressing Coronin-1-EGFP were generated using CRISPR-Cas9. We observed that Coronin-1 localizes at the reconnecting junction during cell rearrangement, which is dependent on actin interacting protein 1 (AIP1) and cofilin, actin disassemblers and known regulators of wing cell rearrangement. Loss of Coronin-1 function reduces cell rearrangement directionality and hexagonal cell fraction. These results suggest that Coronin-1 promotes directional cell rearrangement via its interaction with AIP1 and cofilin, highlighting the role of ABPs in the complex process of morphogenesis.</p><p>Key words: morphogenesis, cell rearrangement, actin binding proteins (ABPs)</p>

    DOI: 10.1247/csf.23049

    Web of Science



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  3. Attachment and detachment of cortical myosin regulates cell junction exchange during cell rearrangement in the Drosophila wing epithelium Reviewed

    Keisuke Ikawa, Shuji Ishihara, Yoichiro Tamori, Kaoru Sugimura

    Current Biology   Vol. 33 ( 2 ) page: 263 - 275.e4   2022.12

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.cub.2022.11.067




  4. Image-based parameter inference for epithelial mechanics Reviewed

    Goshi Ogita, Takefumi Kondo, Keisuke Ikawa, Tadashi Uemura, Shuji Ishihara, Kaoru Sugimura

    PLOS Computational Biology   Vol. 18 ( 6 ) page: e1010209 - e1010209   2022.6

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    Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science (PLoS)  

    Measuring mechanical parameters in tissues, such as the elastic modulus of cell-cell junctions, is essential to decipher the mechanical control of morphogenesis. However, their in vivo measurement is technically challenging. Here, we formulated an image-based statistical approach to estimate the mechanical parameters of epithelial cells. Candidate mechanical models are constructed based on force-cell shape correlations obtained from image data. Substitution of the model functions into force-balance equations at the cell vertex leads to an equation with respect to the parameters of the model, by which one can estimate the parameter values using a least-squares method. A test using synthetic data confirmed the accuracy of parameter estimation and model selection. By applying this method to Drosophila epithelial tissues, we found that the magnitude and orientation of feedback between the junction tension and shrinkage, which are determined by the spring constant of the junction, were correlated with the elevation of tension and myosin-II on shrinking junctions during cell rearrangement. Further, this method clarified how alterations in tissue polarity and stretching affect the anisotropy in tension parameters. Thus, our method provides a novel approach to uncovering the mechanisms governing epithelial morphogenesis.

    DOI: 10.1371/journal.pcbi.1010209


  5. Visualization and Manipulation of Actin Cytoskeleton with Small-Molecular Probes Reviewed

    Takeru Takagi;Tasuku Ueno;Keisuke Ikawa;Daisuke Asanuma;Yusuke Nomura;Shin-nosuke Uno;Toru Komatsu;Mako Kamiya;Kenjiro Hanaoka;Chika Okimura;Yoshiaki Iwadate;Kenzo Hirose;Tetsuo Nagano;Kaoru Sugimura;Yasuteru Urano

    Science Advances     2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1126/sciadv.abg8585

  6. AIP1 and cofilin ensure a resistance to tissue tension and promote directional cell rearrangement. Reviewed

    Ikawa K;Sugimura K

    Nature communications     2018.9

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    Authorship:Lead author   Language:English  

    DOI: 10.1038/s41467-018-05605-7

  7. Inhibition of endocytic vesicle fusion by Plk1-mediated phosphorylation of vimentin during mitosis Reviewed

    Keisuke Ikawa;Ayaka Satou;Mitsuko Fukuhara;Shigeru Matsumura;Naoyuki Sugiyama;Hidemasa Goto;Mitsunori Fukuda;Masaki Inagaki;Yasushi Ishihama;Fumiko Toyoshima

    Cell Cycle     2014.1

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    Authorship:Lead author   Language:English  

    DOI: 10.4161/cc.26866

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KAKENHI (Grants-in-Aid for Scientific Research) 5

  1. 細胞接着分子による圧力依存的な細胞死・離脱誘導メカニズムの解明

    Grant number:24K09469  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    井川 敬介

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

  2. メカニカルコンペティションの遺伝学的解析

    Grant number:24H01400  2024.4 - 2026.3

    科学研究費助成事業  学術変革領域研究(A)

    井川 敬介

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    Authorship:Principal investigator 

    Grant amount:\11310000 ( Direct Cost: \8700000 、 Indirect Cost:\2610000 )

  3. 力学シグナルによる細胞離脱誘導メカニズムの解明

    2023.10 - 2028.3

    武田科学振興財団  2023年度ライフサイエンス研究助成 

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    Authorship:Principal investigator 


  4. 形態形成基幹プロセスの相互作用を担う分子基盤の解明

    Grant number:202110172  2022.4 - 2023.4

    公益財団法人 上原記念生命科学財団  研究奨励金 

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    Authorship:Principal investigator 


  5. 実験と数理から解き明かす、細胞配置換えに伴う細胞間接着再編成の分子メカニズム

    Grant number:19K16139  2019.4 - 2022.3

    日本学術振興会  若手研究 

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    Authorship:Principal investigator  Grant type:Competitive