Updated on 2024/04/02

写真a

 
NIBU Yutaka
 
Organization
Institute for Glyco-core Research Designated associate professor
Title
Designated associate professor

Research History 7

  1. Tokai National Higher Education and Research System, Nagoya University   Institute for Glyco-core Research (iGCORE)   Designated Associate Professor

    2022.5

  2. Tokyo University of Agriculture and Technology   University Research Administration Center   Senior Assistant Professor, Research Administrator

    2018 - 2022.4

  3. University of Tsukuba   Research Administration/Management Office   Research Administrator

    2015

  4. Weill Cornell Medicine   Department of Cell and Developmental Biology   Assistant Professor

    2002

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    Country:United States

  5. JSPS Postdoctoral Fellowships for Research Abroad

    1998 - 2000

  6. University of California at Berkeley   Department of Molecular and Cell Biology   Postdoctoral Fellow, Associate Specialist

    1997

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    Country:United States

  7. University of Tsukuba   Institute of Applied Biochemistry   Research Associate

    1995

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Education 1

  1. University of Tsukuba   Graduate School of Agricultural Sciences, Division of Applied Biochemistry

    - 1995

Professional Memberships 6

  1. Research Manager and Administrator Network Japan

    2015

  2. The Genetics Society of America

    2002 - 2013

  3. The Society for Developmental Biology

    2002 - 2013

  4. American Association for the Advancement of Science

    1998 - 2004

  5. 日本分子生物学会

    1992 - 2002

  6. 日本生化学会

    1992 - 1997

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Papers 28

  1. Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro Reviewed

    Mami Oba, Wen Rongduo, Akatsuki Saito, Tamaki Okabayashi, Tomoko Yokota, Junko Yasuoka, Yoko Sato, Koji Nishifuji, Hitoshi Wake, Yutaka Nibu, Tetsuya Mizutani

    Biochemical and Biophysical Research Communications   Vol. 570   page: 21 - 25   2021.9

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.bbrc.2021.07.034

  2. The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster Reviewed

    Sano, H., Nakamura, A., Texada, M.J., Truman, J.W., Ishimoto, H., Kamikouchi, A., Nibu, Y., Kume, K., Ida, T., Kojima, M.

    PLoS Genetics   Vol. 11 ( 5 ) page: e1005209   2015.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pgen.1005209

    Web of Science

    Scopus

    PubMed

  3. Brachyury, Foxa2 and the cis-Regulatory Origins of the Notochord Reviewed

    José-Edwards, D.S., Oda-Ishii, I., Kugler, J.E., Passamaneck, Y.J., Katikala, L., Nibu, Y., Di Gregorio, A.

    PLoS Genetics   Vol. 11 ( 12 )   2015

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science  

    DOI: 10.1371/journal.pgen.1005730

    Scopus

  4. From notochord formation to hereditary chordoma: The many roles of brachyury Reviewed

    Nibu, Y., José-Edwards, D.S., Di Gregorio, A.

    BioMed Research International   Vol. 2013   page: 1 - 14   2013

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Hindawi Limited  

    Chordoma is a rare, but often malignant, bone cancer that preferentially affects the axial skeleton and the skull base. These tumors are both sporadic and hereditary and appear to occur more frequently after the fourth decade of life; however, modern technologies have increased the detection of pediatric chordomas. Chordomas originate from remnants of the notochord, the main embryonic axial structure that precedes the backbone, and share with notochord cells both histological features and the expression of characteristic genes. One such gene is<italic>Brachyury</italic>, which encodes for a sequence-specific transcription factor. Known for decades as a main regulator of notochord formation,<italic>Brachyury</italic>has recently gained interest as a biomarker and causative agent of chordoma, and therefore as a promising therapeutic target. Here, we review the main characteristics of chordoma, the molecular markers, and the clinical approaches currently available for the early detection and possible treatment of this cancer. In particular, we report on the current knowledge of the role of<italic>Brachyury</italic>and of its possible mechanisms of action in both notochord formation and chordoma etiogenesis.

    DOI: 10.1155/2013/826435

    Scopus

  5. Optimization of a Method for Chromatin Immunoprecipitation Assays in the Marine Invertebrate Chordate Ciona Reviewed

    Aihara, H., Katikala, L., Zeller, R.W., Di Gregorio, A., Nibu, Y.

    Marine Biotechnology   Vol. 15 ( 5 ) page: 520 - 525   2013

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s10126-013-9504-5

    Scopus

  6. Functional Brachyury Binding Sites Establish a Temporal Read-out of Gene Expression in the Ciona Notochord Reviewed

    Katikala, L., Aihara, H., Passamaneck, Y.J., Gazdoiu, S., José-Edwards, D.S., Kugler, J.E., Oda-Ishii, I., Imai, J.H., Nibu, Y., Di Gregorio, A.

    PLoS Biology   Vol. 11 ( 10 ) page: e1001697   2013

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science  

    DOI: 10.1371/journal.pbio.1001697

    Scopus

  7. Akirin links twist-regulated transcription with the brahma chromatin remodeling complex during embryogenesis Reviewed

    Nowak, S.J., Aihara, H., Gonzalez, K., Nibu, Y., Baylies, M.K.

    PLoS Genetics   Vol. 8 ( 3 ) page: e1002547   2012

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science  

    DOI: 10.1371/journal.pgen.1002547

    Scopus

  8. Tbx2/3 is an essential mediator within the brachyury gene network during Ciona notochord development Reviewed

    José-Edwards, D.S., Oda-Ishii, I., Nibu, Y., Di Gregorio, A.

    Development (Cambridge)   Vol. 140 ( 11 )   2012

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1242/dev.094227

    Scopus

  9. CtBP is required for proper development of peripheral nervous system in Drosophila Reviewed

    Stern, M.D., Aihara, H., Roccaro, G.A., Cheung, L., Zhang, H., Negeri, D., Nibu, Y.

    Mechanisms of Development   Vol. 126 ( 1-2 )   2009

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.mod.2008.10.003

    Scopus

  10. Drosophila Ebi mediates Snail-dependent transcriptional repression through HDAC3-induced histone deacetylation Reviewed

    Qi, D., Bergman, M., Aihara, H., Nibu, Y., Mannervik, M.

    EMBO Journal   Vol. 27 ( 6 )   2008

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/emboj.2008.26

    Scopus

  11. Structurally related Arabidopsis ANGUSTIFOLIA is functionally distinct from the transcriptional corepressor CtBP Reviewed

    Stern, M.D., Aihara, H., Cho, K.-H., Kim, G.-T., Horiguchi, G., Roccaro, G.A., Guevara, E., Sun, H.H., Negeri, D., Tsukaya, H., Nibu, Y.

    Development Genes and Evolution   Vol. 217 ( 11-12 )   2007

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00427-007-0186-8

    Scopus

  12. The acetyltransferase activity of Drosophila CBP is dispensable for regulation of the Dpp pathway in the early embryo Reviewed

    Lilja, T., Aihara, H., Stabell, M., Nibu, Y., Mannervik, M.

    Developmental Biology   Vol. 305 ( 2 )   2007

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ydbio.2007.01.036

    Scopus

  13. Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene. Reviewed

    Date, S., Nibu, Y., Yanai, K., Hirata, J., Yagami, K., Fukamizu, A.

    International journal of molecular medicine   Vol. 13 ( 5 )   2004

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    Publishing type:Research paper (scientific journal)  

    Scopus

  14. CtBP-independent repression in the Drosophila embryo Reviewed

    Nibu, Y., Senger, K., Levine, M.

    Molecular and Cellular Biology   Vol. 23 ( 11 )   2003

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/MCB.23.11.3990-3999.2003

    Scopus

  15. Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome Reviewed

    Berman, B.P., Nibu, Y., Pfeiffer, B.D., Tomancak, P., Celniker, S.E., Levine, M., Rubin, G.M., Eisen, M.B.

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 99 ( 2 ) page: 757 - 757   2002

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.231608898

    Scopus

  16. CtBP-dependent activities of the short-range giant repressor in the Drosophila embryo Reviewed

    Nibu, Y., Levine, M.S.

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 98 ( 11 )   2001

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.111158298

    Scopus

  17. Local action of long-range repressors in the Drosophila embryo Reviewed

    Nibu, Y., Zhang, H., Levine, M.

    EMBO Journal   Vol. 20 ( 9 )   2001

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/emboj/20.9.2246

    Scopus

  18. Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor Reviewed

    Yanai, K., Hirota, K., Taniguchi-Yanai, K., Shigematsu, Y., Shimamoto, Y., Saito, T., Chowdhury, S., Takiguchi, M., Arakawa, M., Nibu, Y., Sugiyama, F., Yagami, K.-I., Fukamizu, A.

    Journal of Biological Chemistry   Vol. 274 ( 49 )   1999

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.274.49.34605

    Scopus

  19. Transcriptional coregulators in development Reviewed

    Mannervik, M., Nibu, Y., Zhang, H., Levine, M.

    Science   Vol. 284 ( 5414 ) page: 606 - 609   1999

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/science.284.5414.606

    Scopus

  20. dCtBP mediates transcriptional repression by Knirps, Kruppel and Snail in the Drosophila embryo Reviewed

    Nibu, Y., Zhang, H., Bajor, E., Barolo, S., Small, S., Levine, M.

    EMBO Journal   Vol. 17 ( 23 ) page: 7009 - 7020   1998

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    Scopus

  21. The tumor suppressor protein CtBP mediates short-range repression in the Drosophila embryo

    Nibu, Y., Zhang, H., Ohtsuki, S., Levine, M.

    FASEB Journal   Vol. 12 ( 8 )   1998

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    Publishing type:Research paper (scientific journal)  

    Scopus

  22. Interaction of short-range repressors with Drosophila CtBP in the embryo Reviewed

    Nibu, Y., Zhang, H., Levine, M.

    Science   Vol. 280 ( 5360 ) page: 101 - 103   1998

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/science.280.5360.101

    Scopus

  23. Characterization of a novel Alginate Lyase from Flavobacterium multivolum K-11. Reviewed

    Takeuchi T, Nibu Y, Murata K, Yoshida S, Kusakabe I

    Food Sci. Technol. Int.   Vol. 3 ( 4 ) page: 288 - 392   1997

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    Language:English   Publisher:Japanese Society for Food Science and Technology  

    An alginate lyase was purified from an extracellular enzyme (commercial preparation) of <I>Flavobacterium multivolum </I>K-11 by successive column chromatographies, such as cation exchange, chromatofocusing, and gel filtration. The purified enzyme migrated as a single band on SDS-PAGE and analytical isoelectric focusing. The molecular weight of the enzyme was 32,000 by SDS-PAGE and 33,000 by HPLC gel filtration chromatography, and the pI of the enzyme was 8.2 on isoelectric focusing. The enzyme exhibited maximum activity at pH 7.5 and 40°C, and was stable between pH 6.0 and 9.0, and at temperatures up to 20°C. The enzyme activity was remarkably inhibited by chemical compounds such as SDS, MIA, TNBS, and <I>N</I>-bromosuccinimide, while EDTA and PCMB had no effect on the enzyme activity. The enzyme decomposed both the G-block (guluronic acid content; 89%) and the M-block (mannuronic content; 92%) at nearly equal rates, and produced several kinds of unsaturated oligomers. Because such activity of alginate lyase has not been reported, we believe that this is a novel alginate lyase.

    DOI: 10.3136/fsti9596t9798.3.388

  24. Purification and characterization of endo Poly (alpha-L-Guluronate) Lyase in the enzyme system from Flavobacterium multivolum. Reviewed

    Takeuchi T, Nibu Y, Murata K, Kusakabe I

    Food Sci. Technol. Int.   Vol. 3 ( 1 ) page: 22 - 26   1997

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    Language:English   Publisher:Japanese Society for Food Science and Technology  

    An alginate lyase was purified from a crude enzyme of <I>Flavobacterium multivolum</I> K-11 by successive column chromatographies, such as cation exchange, chromatofocusing, and gel filtration. The enzyme thus obtained migrated as a single band on SDS-PAGE. The relative molecular mass of the enzyme was 43-kDa by SDS-PAGE and 41-kDa by HPLC gel filtration chromatography. The isoelectric point of the enzyme was 8.7. The enzyme exhibited maximum activity at pH 8.0 and 40°C, and was stable in the pH range of 6.0 to 9.0 and at temperatures up to 30°C. The enzyme activity was remarkably inhibited by chemical compounds such as EDTA, PCMB, MIA, TNBS, and <I>N</I>-bromosuccinimide. The enzyme was specific for poly-guluronate and produced several kinds of oligomers. Thus, the results suggested that the enzyme was classified as endo poly (α-L-guluronate) lyase (EC 4.2.2.11).

    DOI: 10.3136/fsti9596t9798.3.22

  25. A cis-acting DNA element located between TATA box and transcription initiation site is critical in response to regulatory sequences in human angiotensinogen gene Reviewed

    Yanai, K., Nibu, Y., Murakami, K., Fukamizu, A.

    Journal of Biological Chemistry   Vol. 271 ( 27 )   1996

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.271.27.15981

    Scopus

  26. Human activin βA gene: Identification of novel 5′ exon, functional promoter, and enhancers Reviewed

    Tanimoto, K., Yoshida, E., Mita, S., Nibu, Y., Murakami, K., Fukamizu, A.

    Journal of Biological Chemistry   Vol. 271 ( 51 )   1996

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    Publishing type:Research paper (scientific journal)  

    Scopus

  27. Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter region

    Kobayashi, S.-i., Ohnishi, J., Nibu, Y., Nishimatsu, S.-i., Umemura, S., Ishii, M., Murakami, K., Miyazaki, H.

    BBA - Gene Structure and Expression   Vol. 1262 ( 2-3 )   1995

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/0167-4781(95)00076-S

    Scopus

  28. Purification and characterization of extracellular alginate lyase from enterobacter cloacae m-1 Reviewed

    Nibu, Y., Satoh, T., Nishi, Y., Takeuchi, T., Murata, K., Kusakabe, I.

    Bioscience, Biotechnology and Biochemistry   Vol. 59 ( 4 ) page: 632 - 637   1995

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Society for Bioscience, Biotechnology, and Agrochemistry  

    An alginate lyase from the culture supernatant of Enterobacter cloacae M-1 was purified by ammonium sulfate precipitation, cation-exchange chromatography (SP-Toyopearl), and gel filtration (Ultrogel AcA44). The final preparation thus obtained showed a single band on SDS-PAGE. The purified enzyme had the molecular weight of 38, 000 and 32, 000 by SDS-PAGE and gel filtration, respectively. The pI of the enzyme was 8. 9. The optimum pH and temperature for the enzyme reaction were around 7. 8 and 30℃, respectively. The enzyme was unstable on heating. EDTA completely inhibited the enzyme activity, but the activity was completely restored by the treatment with CaCl_2. The enzyme was specific for poly-guluronate and produced several kinds of unsaturated oligomers from the gluluronate. This suggested that the enzyme could be classified as an endo poly-guluronate lyase.

    DOI: 10.1080/bbb.59.632

    Scopus

    CiNii Books

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Books 7

  1. 「東京農工大学の研究活動とその社会貢献」木材工業 76, 402-405, 2021年

    二歩 裕

    木材工業  2021.10 

  2. 「俯瞰ワークショップ報告書 社会および産業競争力を支える基盤としての環境リスク評価研究」CRDS-FY2019-WR-05(分担執筆)

    国立研究開発法人科学技術振興機構  2020 

  3. 「東京農工大学における共同研究推進の取り組み」pp203-210. 書籍の題:「共同研究開発の進め方と契約のポイント」

    二歩 裕, 伊藤 伸

    技術情報協会出版  2020 

  4. 「戦略プロポーザル 環境調和型プラスチック戦略〜化学物質としてのプラスチックの安全な管理・活用を推進するための戦略的研究〜」CRDS-FY2019-SP-07(分担執筆)

    (国立研究開発法人科学技術振興機構 研究開発戦略センター)

    国立研究開発法人科学技術振興機構  2020 

  5. Transcriptional repression by the CtBP corepressor in Drosophila. In: CtBP Family Proteins (ed. D. Chinnadurai), Chapter 2, p18-27

    Aihara H, Perrone L, Nibu Y(Chapter 2, p18-27)

    Landes Bioscience  2007 

  6. Transcriptional repressors and repression mechanisms. In: Gene Expression and Regulation (ed. J. Ma), Chapter 09, p159-173

    Perrone L, Aihara H, Nibu Y(Chapter 09, p159-173)

    Current Scientific Frontiers Book, Higher Education Press  2006 

  7. New aspect of the renin-angiotensin system: focus on regulation of human angiotensinogen gene. Blood Vessel and Endothelium 6(5), 478-486 (1996), in Japanese

    Nibu Y, Fukamizu A

    1996 

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MISC 2

  1. Regulated expression of human angiotensinogen gene by HNF4 and COUP-TF

    K Hirota, K Yanai, K Taniguchi-Yanai, Y Shigematsu, Y Shimamoto, T Saito, M Arakawa, Y Nibu, A Fukamizu

    JOURNAL OF HYPERTENSION   Vol. 18   page: S183 - S183   2000

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

    Web of Science

  2. Functional characterization of the Factor Binding to the 3'Downstream Enhan cer Core Element of human Angiotensinogen Gene

    DATE S., YANAI K., NIBU Y., MURAKAMI K., FUKAMIZU A.

      Vol. 21   page: 397 - 397   1998.12

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    Language:Japanese  

    CiNii Books

Presentations 10

  1. 東京農工大学におけるチーム型研究の推進とベンチャー創出・育成の取組

    齋藤 憲一郎, 二歩 裕, 前畑 英雄

    RA協議会第7回年次大会  2021.9.14 

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    Event date: 2021.9

  2. 民間企業からの投資のゆくえ -産学連携の伸びしろの可能性-

    佐野 恵利子, 伊藤 広幸, 二歩 裕

    RA協議会第7回年次大会  2021.9.14 

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    Event date: 2021.9

  3. A new strategy to facilitate academia-industry research collaboration and research expense hunting using disclosed information at University of Tsukuba.

    Sazawa H, Akutsu Y, Komatsubara S, Nukaga M, Ito M, Nibu Y, Baba T

    INORMS 2016 (The International Network of Research Management Societies)  2016 

  4. 筑波大学の国際産学連携の方針と部局から生まれた社会での応用事例 Invited

    二歩裕

    日本台湾産学連携推進セミナー(台北駐日経済文化代表処)  2016 

  5. 研究マネジメント人材の獲得戦略 〜ニーズに呼応したトランスフォーメーション〜

    伊藤広幸, 佐野恵利子, 二歩 裕

    研究・イノベーション学会第37年次学術大会  2022.10.30 

  6. 次世代の研究力マップ -博士人材育成を起源とする研究力指標-

    伊藤 広幸, 佐野 恵利子, 二歩 裕

    RA協議会第5回年次大会  2019 

  7. 主要国における分野別論文数の動向 -2つの書誌データベースの特⻑を知り、活かして、上手に活用するには-」

    二歩 裕, 伊藤 広幸, 佐野 恵利子

    RA協議会第4回年次大会  2018 

  8. URAの業務拡大と求められる専門性の変化(II)

    佐野 恵利子, 伊藤 広幸, 二歩 裕

    RA協議会第8回年次大会  2022.8.30 

  9. URAの業務拡大と求められる専門性の変化

    佐野 恵利子, 伊藤 広幸, 二歩 裕

    RA協議会第6回年次大会  2020 

  10. Strategy from building of interdisciplinary research to global collaborations at Tokyo University of Agriculture and Technology.

    Nibu Y, Saito K

    INORMS 2021 (The International Network of Research Management Societies )  2021 

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Other research activities 7

  1. 社会還元加速プログラム(SCORE)大学推進型(大学推進型(拠点都市環境整備型) 事業 『T-UNITE(Tokyo United Network for Innovation with Technology and Entrepreneurs)』 2021年度 起業家育成講座を運営する指導・支援人材の育成プログラム(コーチング研修、スタートアップ講座、デザイン思考コース)修了

    2022

  2. Virtual Teaching and Learning Studio program (vTLS), Hasso Plattner Institute of Design (d.school), Stanford University

    2021

  3. Waseda University T-UNITE – Babson Global Symposium for Entrepreneurship Educators

    2021

  4. JST 目利き人材育成研修、研究推進マネジメントコース 修了

    2018

  5. 筑波大学Rcus大学マネジメントセミナー 修了

    2018

  6. RA協議会リサーチアドミニストレーター新任研修 修了

    2016

  7. JST プログラムマネージャー(PM)育成・活躍推進プログラム研修 修了

    2015
    -
    2016

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Social Contribution 1

  1. 講義 ニューヨーク市立小学校(PS78)

    Role(s):Lecturer

    2012

Academic Activities 3

  1. RA協議会第6回年次大会 実行委員/セッション担当

    Role(s):Planning, management, etc.

    2020

  2. 写真提供 第一学習社「高等学校生物」と「最新図説生物」

    2013

  3. Gene ControlのChapter 8: Gene Control and Cellular Signalling Pathways(第8章「遺伝子調節とシグナル伝達経路」)日本語訳

    2012