Updated on 2023/10/12

写真a

 
NAKASHIMA Fumie
 
Organization
Graduate School of Bioagricultural Sciences Department of Applied Biosciences Assistant Professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences Department of Applied Biosciences
Title
Assistant Professor
External link

Degree 1

  1. Ph.D. (Agriculture) ( 2018.3   Nagoya University ) 

Research Areas 2

  1. Life Science / Food sciences

  2. Life Science / Pharmacology  / bioactive lipids

Current Research Project and SDGs 2

  1. 食品の機能性に関する研究

  2. 新規生理活性脂質の探索およびその生理活性解明

Research History 4

  1. Nagoya University   Graduate School of Bioagricultural Sciences   Assistant Professor

    2022.2

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    Country:Japan

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  2. Vanderbilt University Medical School   Researcher

    2018.11 - 2022.1

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    Country:United States

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  3. Nagoya University   Graduat   Researcher

    2018.3 - 2018.11

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    Country:Japan

  4. Japan Society for Promotion of Science   Researcher

    2016.4 - 2018.3

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    Country:Japan

Education 3

  1. Nagoya University   Graduate School of Bioagricultural Sciences   Department of Applied Biosciences

    2015.4 - 2018.3

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    Country: Japan

  2. Nagoya University   Graduate School of Bioagricultural Sciences   Department of Applied Biosciences

    2013.4 - 2015.3

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    Country: Japan

  3. Nagoya University   School of Agricultural Sciences   Department of Applied Biosciences

    2009.4 - 2013.3

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    Country: Japan

Professional Memberships 2

  1. 日本生化学会

    2014.9

  2. 日本農芸化学会

    2013

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Awards 1

  1. 名古屋大学学術奨励賞受賞

    2017.6   名古屋大学  

 

Papers 18

  1. Eriodictyol and thymonin act as GPR35 agonists. Reviewed

    Nakashima F, Loh WQ, Wakabayashi M, Shimomura S, Hattori H, Kita M, Inoue A, Uchida K, Shibata T

    Bioscience, biotechnology, and biochemistry     2023.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/bbb/zbad125

    PubMed

  2. The 5-lipoxygenase/cyclooxygenase-2 (5-LOX/COX-2) cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis Reviewed International coauthorship

    Nakashima F, Giménez-Bastida J, Luis P, Presley S, Boer R, Chiusa M, Shibata T, Sulikowski G, Pozzi A, Schneider C

    The Journal of biological chemistry     page: 103050   2023.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbc.2023.103050

    PubMed

  3. Biosynthetic Crossover of 5-Lipoxygenase and Cyclooxygenase-2 Yields 5-Hydroxy-PGE2 and 5-Hydroxy-PGD2 Reviewed International coauthorship

    Nakashima F, Suzuki T, Gordon ON, Golding D, Okuno T, Giménez-Bastida JA, Yokomizo T, Schneider C

    JACS Au   Vol. 1 ( 9 ) page: 1380 - 1388   2021.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacsau.1c00177

    PubMed

  4. Sodium sulfite causes gastric mucosal cell death by inducing oxidative stress Reviewed

    Oshimo M, Nakashima F, Kai K, Matsui H, Shibata T, Akagawa M

    Free Radical Research   Vol. 55 ( 6 ) page: 731 - 743   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/10715762.2021.1937620

    Web of Science

    Scopus

    PubMed

  5. Mechanistic Differences in the Inhibition of NF-κB by Turmeric and Its Curcuminoid Constituents Reviewed International coauthorship

    Edwards RL, Luis PB, Nakashima F, Kunihiro AG, Presley SH, Funk JL, Schneider C

      Vol. 68   page: 6154 - 6160   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

  6. Transformation of Prostaglandin D2 to 11-Dehydro Thromboxane B2 by Baeyer-Villiger Oxidation Reviewed International coauthorship

    Nakashima F, Schneider C

    Lipids   Vol. 55   page: 73 - 78   2019.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  7. A unique mechanism for thiolation of serum albumins by disulphide molecules Invited Reviewed

    Nakashima F, Shibata T, Uchida K

    The Journal of Biochemistry   Vol. 167 ( 2 ) page: 165 - 171   2019.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jb/mvz084

  8. Curcumin induces secretion of glucagon-like peptide-1 through an oxidation-dependent mechanism Reviewed International coauthorship

    Alli-Oluwafuyi AM, Luis PB, Nakashima F, Giménez-Bastida JA, Presley SH, Duvernay MT, Iwalewa EO, Schneider C

    Biochimie   Vol. 165   page: 250 - 257   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1016/j.biochi.2019.08.013

  9. A Dual Perspective of the Action of Lysine on Soybean Oil Oxidation Process Obtained by Combining 1H NMR and LC-MS: Antioxidant Effect and Generation of Lysine-Aldehyde Adducts Reviewed International coauthorship

    Martin-Rubio AS, Sopelana P, Nakashima F, Shibata T, Uchida K, Guillén MD

    Antioxidants   Vol. 8   page: 326   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/antiox8090326

  10. Structural and functional insights into S-thiolation of human serum albumins Reviewed International coauthorship

    Nakashima F, Shibata T, Kamiya K, Yoshitake J, Kikuchi R, Matsushita T, Ishii I, Giménez-Bastida JA, Schneider C, Uchida K

      Vol. 8   page: 932   2018.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-19610-9

  11. Adductome-based identification of biomarkers for lipid peroxidation Reviewed

    Shibata T, Shimizu K, Hirano K, Nakashima F, Kikuchi R, Matsushita T, Uchida K

    Journal of Biological Chemistry   Vol. 292 ( 2 ) page: 8223 - 8235   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M116.762609

  12. Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes Reviewed International coauthorship

    Luis PB, Gordon ON, Nakashima F, Joseph AI, Shibata T, Uchida K, Schneider C

    Biochemical Pharmacology   Vol. 132   page: 143 - 149   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1016/j.bcp.2017.03.002

  13. Oxidative deamination of serum albumins by (-)-epigallocatechin-3-O-gallate: A potential mechanism for the formation of innate antigens by antioxidants Reviewed

    Hatasa Y, Chikazawa M, Furuhashi M, Nakashima F, Shibata T, Kondo T, Akagawa M, Hamagami H, Tanaka H, Tachibana H, Uchida K

    PLoS One   Vol. 11 ( 4 ) page: e0153002   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0153002

  14. Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel Reviewed

    Shibata T, Takahashi K, Matsubara Y, Inuzuka E, Nakashima F, Takahashi N, Kozai D, Mori Y, Uchida K

    Scientific Reports   Vol. 6   page: 21261   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep21261

  15. Identification of C1q as a binding protein for advanced glycation end products Reviewed

    Chikazawa M, Shibata T, Hatasa Y, Hirose S, Otaki N, Nakashima F, Ito M, Machida S, Maruyama S, Uchida K

    Bochemistry   Vol. 55   page: 435 - 446   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.biochem.5b00777

  16. Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile Reviewed

    Kumagai T, Usami H, Matsukawa N, Nakashima F, Chikazawa M, Shibata T, Noguchi N, Uchida K

    Redox Biology   Vol. 4   page: 74 - 86   2014.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1016/j.redox.2014.11.011

  17. Toll-like receptors as a target of food-derived anti-inflammatory compounds Reviewed

    Shibata T, Nakashima F, Honda K, Lu YJ, Kondo T, Ushida Y, Aizawa K, Suganuma H, Oe S, Tanaka H, Takahashi T, Uchida K

    Journal of Biological Chemistry   Vol. 289 ( 47 ) page: 32757 - 32772   2014.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M114.585901

  18. Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins Reviewed

    Miyashita H, Chikazawa M, Otaki N, Hioki Y, Shimozu Y, Nakashima F, Shibata T, Hagihara Y, Maruyama S, Matsumi N, Uchida K

      Vol. 4   page: 5343   2014.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep05343

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Books 3

  1. 実験医学増刊「食と健康を結ぶメディカルサイエンス 生体防御系を亢進し、健康の維持に働く分子機構」

    中島史恵、柴田貴広、内田浩二( Role: Joint author ,  システイン残基のユニークな自然修飾)

    羊土社  2020  ( ISBN:978-4-7581-0387-9

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    Responsible for pages:52-58   Language:Japanese Book type:Scholarly book

  2. 実験医学「レドックス疾患学」

    中島史恵、柴田貴広、内田浩二( Role: Joint author ,  脂質異常症に関連したタンパク質のS-チオール化)

    羊土社  2018  ( ISBN:978-4-7581-0369-5

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    Responsible for pages:264-270   Language:Japanese Book type:Scholarly book

  3. ケルセチン及びケルセチン配糖体によるToll様受容体シグナリング抑制 Reviewed

    中島史恵、柴田貴広、内田浩二( Role: Joint author)

    日本ポリフェノール学会雑誌  2016 

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    Responsible for pages:38-42   Language:Japanese

KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. 疾患状態を反映する代謝物アダクトームの解明

    Grant number:23K17449  2023.6 - 2027.3

    科学研究費助成事業  挑戦的研究(開拓)

    柴田 貴広, 中島 史恵, 佐藤恵美, 服部 浩之

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    Authorship:Coinvestigator(s) 

    疾患状態に起因する内因性代謝物や食品由来成分の代謝物の一部が、生体内のタンパク質に様々な付加体(アダクト)を形成していることが知られている。生体内タンパク質における代謝物アダクトの総体「代謝物アダクトーム」を明らかにすることができれば、ヒトの生体内環境や疾患状態を理解・評価できると考えられる。本研究では、代謝物アダクトーム解析法を確立し、生体内の状態や疾患状態を反映する代謝物アダクトの同定に挑戦する。

  2. 新規エイコサノイドhemiketal E2によるタンパク質修飾を介した血管新生機構の解明

    Grant number:23K13881  2023.4 - 2025.3

    科学研究費助成事業  若手研究

    中島 史恵

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Hemiketal E2は機能未知のアラキドン酸由来生理活性脂質であり、研究代表者は、HKE2が血管内皮細胞においてvascular endothelial growth factor receptor 2のリン酸化を介して血管新生を誘導することを明らかにしてきた。しかし、その詳細なメカニズムは不明である。本研究では、HKE2の化学的特性から「Cys残基がHKE2によって修飾された特定のタンパク質が血管新生に関与する」という仮説を立て、これを検証する。

  3. 脂質酸化酵素のクロストークにより産生される新規生理活性脂質の探索

    Grant number:22K20570  2022.8 - 2024.3

    科学研究費助成事業  研究活動スタート支援

    中島 史恵

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    Authorship:Principal investigator 

    Grant amount:\2860000 ( Direct Cost: \2200000 、 Indirect Cost:\660000 )

    アラキドン酸は、リポキシゲナーゼ (LOX) 経路もしくはシクロオキシゲナーゼ (COX) 経路の2つの古典的経路によりエイコサノイドへと代謝され、炎症や組織の恒常性維持において中心的役割を果たす。しかし、慢性炎症性疾患の発症を既知のエイコサノイドの生合成阻害では完全に抑制できないことから、古典的経路で生合成されるエイコサノイドだけでは全ての生体応答を説明することができず、アラキドン酸代謝経路の全容解明が求められている。そこで本研究では、”5-LOX/COX-2クロストーク”により生成される新規エイコサノイドの探索と、その生理活性の解明を目指す。

 

Teaching Experience (On-campus) 4

  1. Chemical Biology

    2023

  2. 応用生命科学科実験実習

    2023

  3. Chemical Biology

    2022

  4. 応用生命科学科実験実習

    2022