Synthesis of Diazatricyclic Molecules via Intramolecular Cycloaddition of Azomethine Ylides 査読有り

S. Kato, K. Morita, N. Umekubo, S. Yokoshima

Org. Lett.     2025年9月

Synthesis of 2,6-Diazabicyclo[3.3.1]nonanes via Intramolecular Cycloaddition of Nitrones 査読有り

R. Kawai, A. Nakamuira, Y. Irie, N. Umekubo, S. Yokosima

Org. Biomol. Chem.     2025年8月

Stereoselective Synthesis of Delgocitinib and Its Diastereomer Using Organocatalyzed Michael Addition 査読有り

K. Morita, N. Umekubo, H. Matsuzaki, K. Tsutsumi, S. Yokoshima

Org. Lett.   27 巻   頁： 6789 - 6793   2025年7月

Construction of Nitrogen-Containing Three-Dimensional Frameworks via Formation and Cycloaddition of endo-Cyclic Azomethine Ylide 査読有り Open Access

K. Furuhashi, N. Umekubo, Y. Matsuyuki, S. Yokoshima

Org. Lett.   27 巻   頁： 4904 - 4908   2025年5月

Total Synthesis of Melonine 査読有り

Y. Matsuyuki, N. Umekubo, S. Yokoshima

Org. Lett.   27 巻   頁： 2065 - 2068   2025年2月

Organocatalyst-mediated asymmetric one-pot/two domino/three-component coupling reactions for the synthesis of trans-hydrindanes 査読有り Open Access

N. Mori, T. Tachibana, N. Umekubo, Y. Hayashi

Chem. Sci.,   15 巻   頁： 5627 - 5632   2024年3月

Deep learning driven de novo drug design based on gastric proton pump structures 招待有り 査読有り Open Access

  6 巻   頁： 956   2023年9月

Total syntheses of macleanine and lycoposerramine-S 査読有り Open Access

M. Okuyama, N. Umekubo, K. Akimoto, T. Shimizu, K. Kubokoya, N. Nakajima, Y. Nishiyama, S. Yokoshima

Org. Biomol. Chem.   21 巻   頁： 6289 - 6292   2023年7月

Total Synthesis of Kopsone 査読有り

Kazutoshi Tomoya , Kazuaki Komiya, Daisuke Nakajima, Nariyoshi Umekubo, Satoshi Yokoshima

Organic Letters   25 巻 ( 25 ) 頁： 2718 - 2721   2023年4月

Diphenylprolinol Silyl Ether Catalyzed Asymmetric Formal Carbo [3+3] Cycloaddition Reaction of Isopropylidenemalononitrile and α,β-Unsaturated Aldehyde 査読有り

Nariyoshi Umekubo, Xiaolei Han, Naoki Mori, Yujiro Hayashi

European Journal of Organic Chemistry   ( 26 ) 頁： e202200603   2022年6月

Catalytic Asymmetric Michael Reaction of Methyl Alkynyl Ketone Catalyzed by Diphenylprolinol Silyl Ether 招待有り 査読有り Open Access

Nariyoshi Umekubo, Yujiro Hayashi

ACS Organic & Inorganic Au   2 巻 ( 3 ) 頁： 245 - 251   2022年1月

Asymmetric Synthesis of Pentasubstituted Cyclohexanes through Diphenylprolinol Silyl Ether Mediated Domino Michael/Michael Reaction 査読有り

Amaechi Shedrack Odoh, Louise Aidanpää, Nariyoshi Umekubo, Hiroaki Matoba, Naoki Mori, Yujiro Hayashi

Eur. J. Org. Chem.     2021年10月

Synthesis of Bicyclo[2.2.2]octanes with a Quaternary Bridgehead Carbon by Diphenylprolinol Silyl Ether-mediated Domino Reaction 査読有り

Nariyoshi Umekubo, Tohru Taniguchi, Kenji Monde, Yujiro Hayashi

Asian. J. Org. Chem.     2021年10月

Asymmetric Domino Reaction of α,β-Unsaturated Aldehydes and α-Acyl α,β-Unsaturated Cyclic Ketones Catalyzed by Diphenylprolinol Silyl Ether 招待有り 査読有り

Yujiro Hayashi, Yurina Suga, Nariyoshi Umekubo

Org. Lett.     2020年10月

Evidence for an enolate mechanism in the asymmetric Michael reaction of α,β-unsaturated aldehydes and ketones via a hybrid system of two secondary amine catalysts 査読有り Open Access

Nariyoshi Umekubo, Takahiro Terunuma, Eunsang Kwon, Yujiro Hayashi

Chem. Sci.     2020年9月

Asymmetric Synthesis of Corey Lactone and Latanoprost 査読有り

Nariyoshi Umekubo, Yujiro Hayashi

Eur. J. Org. Chem.     2020年8月

Asymmetric One-Pot Mukaiyama Michael/Michael Reaction Catalyzed by Diphenylprolinol Silyl Ether 査読有り

Nariyoshi Umekubo, Yujiro Hayashi

Eur. J. Org. Chem.     2020年7月

One-pot Synthesis of Chiral cis-Hydrindanes via Diphenylprolinol Silyl Ether Mediated Domino Reaction and Aldol Condensation 査読有り

Nariyoshi Umekubo, Ryohei Iwata, Yujiro Hayashi

Chem. Lett.     2020年4月

Prolinate Salts as Catalysts for α-Aminoxylation of Aldehyde and Associated Mechanistic Insights 査読有り

Yujiro Hayashi, Taku Hirama, Nariyoshi Umekubo

Org. Lett.     2017年8月